Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.

Naringin Dihydrochalcone(Naringin DC)是一种新型甜味剂，源自于柑橘中发现的苦味化合物naringin。其甜度为蔗糖的500-700倍，因具有高甜味、低热量、无害和安全等优点，在食品、医药和商品交易中有广泛应用。Naringin DC鉴于其清新的口感、持久的余味、特有的淡雅香气以及优良的掩蔽苦味能力，特别适用于乳制品、油脂类食品、冷冻食品、加工蔬菜、果冻、果酱、无酒精饮料、口香糖、牙膏和压片糖果等。此外，它还可用作糖的替代品，以减少身体对糖分的吸收，对于肥胖者和糖尿病患者而言是一大福音。

处理naringin显著减轻糖尿病大鼠的肾损伤，并显著增加糖尿病大鼠的体重。Naringin的给药有效减轻糖尿病大鼠的胶原沉积和肾间质纤维化。Naringin的处理可降低ROS和MDA的水平，并增加SOD和GSH-Px的活性[2]。口服naringin显著改善学习和记忆能力。Naringin显著增强胰岛素信号传导途径[3]。

HBZY-1 cells are plated into 96-well plates and pretreated with various concentrations(1, 5, 10, 25, 50, 100 μM) of naringin for 2 h. Then cells are treated with 30 mM glucose for 24 h. The control group is added sterile normal saline in the same volume. After treatment, all the wells are incubated with 20 μl of 5 mg/ml MTT for 4 h at 37°C. Subsequently, 100 μl of DMSO are used to dissolve the formed formazan crystals after removal of the supernatant. The result is recorded at 490 nm on a microplate reader[1].