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LCH-7749944 (GNF-PF-2356) 是一种 PAK4抑制剂,IC50为 14.93 μM。它通过下调 PAK4/c-Src/EGFR/cyclin D1 途径有效抑制人胃癌细胞的增殖,并诱导凋亡。
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LCH-7749944 (GNF-PF-2356) 是一种 PAK4抑制剂,IC50为 14.93 μM。它通过下调 PAK4/c-Src/EGFR/cyclin D1 途径有效抑制人胃癌细胞的增殖,并诱导凋亡。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 663 | 现货 | |
5 mg | ¥ 1,630 | 现货 | |
10 mg | ¥ 2,380 | 现货 | |
25 mg | ¥ 3,970 | 现货 | |
50 mg | ¥ 5,670 | 现货 | |
100 mg | ¥ 7,930 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 1,780 | 现货 |
产品描述 | LCH-7749944 (GNF-PF-2356) effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor with an IC50 of 14.93 μM. |
靶点活性 | PAK4:14.93 μM |
体外活性 | LCH-7749944 (5-20 μM; 12-48 hours) prominently induces a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase. ?LCH-7749944 (5-30 μM; 24 hours) dramatically decreases levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner.?LCH-7749944 (GNF-PF-2356;?5-50 μM;?24 hours) inhibits the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner.??LCH-7749944 (5-20 μM;?12-48 hours) induces apoptosis of SGC7901 cells. |
别名 | GNF-PF-2356 |
分子量 | 350.41 |
分子式 | C20H22N4O2 |
CAS No. | 796888-12-5 |
Smiles | COc1cccc(Nc2nc(NCC3CCCO3)c3ccccc3n2)c1 |
密度 | 1.272 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 250 mg/mL (713.45 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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