vatalanib

Vatalanib free base 是一种 VEGFR2 KDR 的抑制剂，其IC50=37nM。

Vatalanib hydrochloride (PTK787 hydrochloride)作为VEGFR2 KDR的抑制剂，表现出显著的抑制效果，其IC50值仅为37nM。

Vatalanib succinate is a VEGFR, PDGFR-β, c-Kit, c-Fms, and aromatase inhibitor.

Vatalanib dihydrochloride (PTK787 dihydrochloride) 是一种VEGFR2 KDR 的抑制剂，其IC50值为37nM。

ZK-261557 is a new oral antiangiogenic molecule that inhibits all known vascular endothelial growth factor receptors. Vatalanib is under investigation for the treatment of solid tumors.

SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7, in vivo. Vps34 inhibitor significantly potentiated cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro in monolayer cultures and when grown as multicellular spheroids. Our data suggests that inhibition of autophagy significantly improves sensitivity to Sunitinib and Erlotinib and that Vps34 is a promising therapeutic target for combination strategies in breast cancer.