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Search Results for " triple "

Targets Recommended: Others Ras

113

抑制剂 & 化合物

9

天然产物

1

化合物库

17

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L2191	抗乳腺癌化合物库		1939 compounds
	1939 种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究；

化合物库

抗乳腺癌化合物库

Cat.No: L2191

Compounds: 1939

Cat. No.	Product Name	Target	Signaling Pathways
T9407	Rasarfin	Others; Ras	GPCR/G Protein; MAPK; Others
	Rasarfin 是Ras 和ARF6双抑制剂。
T9468	FR054	Others	Others
	FR054 是一种己糖胺生物合成途径酶 PGM3 的抑制剂，具有明显的抗乳腺癌活性。它在不同的乳腺癌细胞中诱导细胞增殖和存活显著降低。
T41256	SP-96	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	SP-96 是一种高效的特异性 Aurora B 抑制剂，IC50 为 0.316 nM。 SP-96 在 NCI60 筛选中显示特异性生长抑制，如 MDA-MD-468 (GI50=107 nM)。 SP-96 可用于三阴性乳腺癌研究。
T10860	Col003	HSP	Cytoskeletal Signaling; Metabolism
	Col003 是一种选择性和有效的 Hsp47 抑制剂，可竞争性结合 Hsp47 上的胶原蛋白结合位点，IC50为1.8 μM。它通过破坏胶原蛋白三螺旋的稳定性来抑制胶原蛋白的分泌，可用于肺纤维化的相关研究。
T13780	MS1943	Apoptosis; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	MS1943 是一种具有口服生物活性的 EZH2选择性降解剂，IC50为 120 nM。它显著降低了许多三阴性乳腺癌和其他癌及非癌细胞系中的 EZH2蛋白水平，能有效阻止多个三阴性乳腺癌和其他癌细胞系的增殖。
T6797	Telaglenastat CB 839,CB839,CB-839	transporter; Glutaminase; Autophagy	Autophagy; Metabolism; Proteases/Proteasome
	Telaglenastat (CB 839) 是一种谷氨酰胺酶 1 (GLS1) 抑制剂，具有选择性、可逆性和口服活性。Telaglenastat 具有抗肿瘤活性，可以诱导细胞自噬。
T13044	Mevociclib SY-1365	CDK	Cell Cycle/Checkpoint
	Mevociclib (SY-1365) 是一种高效选择性 CDK7抑制剂，Ki 值为 17.4 nM。它具有抗血液肿瘤和侵袭性实体肿瘤作用，有抗增殖和凋亡活性。
T19664	ON1231320 GBO-006	Apoptosis; PLK	Apoptosis; Cell Cycle/Checkpoint
	ON1231320 (GBO-006) 是一种高度特异性的 polo 样激酶 2 抑制剂，IC50为 0.31 µM。在有丝分裂 G2/M 期阻断肿瘤细胞周期进程，它可导致细胞凋亡。它是一种芳基磺酰基吡啶并嘧啶酮，具有抗肿瘤活性。
T7530	PD146176 NSC168807	Ferroptosis; Lipoxygenase; Autophagy	Apoptosis; Autophagy; Metabolism
	PD146176 (NSC-168807) 是一种 15-脂氧合酶(15-LO)抑制剂，抑制兔网织红细胞 15-LO，Ki 为 197 nM，IC50 为 0.54 μM。它通过刺激老年三重转基因小鼠的自噬来逆转认知障碍、脑淀粉样变性和 tau 病理学。
T2655	CEP-37440 CEP37440	FAK; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	CEP-37440 是一种新型的 FAK (IC50:2.3 nM) 和 ALK (IC50:120 nM) 双重抑制剂。
T9320	YK-3-237 B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) 是 SIRT1 激活剂，靶向突变体 p53。它抑制三阴性乳腺癌细胞的增殖。
T8808L	LYN-1604 dihydrochloride LYN-1604 2HCl（2216753-86-3 free base)	Apoptosis; Autophagy	Apoptosis; Autophagy
	LYN-1604 2HCl 是一种有效的 UNC-51 样激酶 1 激活剂，EC50值为 18.94 nM。LYN-1604 可研究三阴性乳腺癌。
T4123	LYN-1604 LYN1604	Apoptosis; Autophagy	Apoptosis; Autophagy
	LYN-1604 是一种新型 ULK1 激活剂，EC50值为 18.94 nM。它可诱导参与 ATF3、RAD21 和 caspase3 的细胞死亡，并伴有自噬和细胞凋亡，可研究三阴性乳腺癌。
T35528	TD52	Apoptosis; Phosphatase; Akt	Apoptosis; Cytoskeletal Signaling; Metabolism; PI3K/Akt/mTOR signaling
	TD52 是 PP2A (CIP2A) 癌性抑制剂的口服活性抑制剂。 TD52 是厄洛替尼衍生物，通过干扰 Elk1 与 CIP2A 启动子的结合间接降低了 CIP2A。
T2092	Amitifadine hydrochloride DOV-21947 hydrochloride,EB-1010 hydrochloride	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Amitifadine hydrochloride (EB-1010 hydrochloride) 是一种 5-羟色胺-去甲肾上腺素-多巴胺的再摄取抑制剂(SNDRI)，其在 HEK 293 细胞中测得的 IC50值分别为 12， 23， 96 nM。
T70353	JG-231	HSP	Cytoskeletal Signaling; Metabolism
	JG-231 是 JG-98 类似物，具有抗癌活性。JG-231 对三阴性乳腺癌 (TNBC) 的 MDA-MB-231 异植肿瘤模型具有抑制作用。JG-231 可抑制 Hsp70-BAG3 的相互作用。JG-231 对三阴性乳腺癌 (TNBC) 的 MDA-MB-231 异植肿瘤模型具有抑制作用。
T8569	DMH-25	mTOR	PI3K/Akt/mTOR signaling
	DMH-25 是一种新型共价有效的 mTOR 抑制剂，在体内对三阴性乳腺癌细胞具有抗肿瘤活性。
T6224	Iniparib NSC-746045,IND-71677,3-硝基-4-碘苯甲酰胺,BSI-201	PARP; Influenza Virus	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	Iniparib (BSI-201) 是一种不可逆的 PARP1抑制剂，在三阴性乳腺 Y 中表现出效力。
T7296	THZ2 CDK7-IN-1	CDK	Cell Cycle/Checkpoint
	THZ2 (CDK7-IN-1) 是 THZ1 的类似物，是一种有效的选择性 CDK7 抑制剂，IC50值为 13.9 nM。它有治疗三阴性乳腺癌的潜力。
T9583	HJ-PI01 N-Acetylphenoxazine,10-acetylphenoxazine	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	HJ-PI01 (HJ-PI01) 是一种 Pim-2 抑制剂。它在三阴性人乳腺癌中诱导细胞凋亡和自噬性细胞死亡。
T3526	Dasotraline hydrochloride SEP-225289 hydrochloride,达索曲林盐酸盐	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Dasotraline hydrochloride (SEP-225289 hydrochloride) 是具有阻断多巴胺 (IC50=4 nM)，去甲肾上腺素 (IC50=6 nM) 和三羟色胺转运蛋白 (IC50=11 nM)的三重再摄取抑制剂。
T74178	Glembatumumab vedotin CR011-vcMMAE,CR 011 ADC,CDX-011	Microtubule Associated; Antibody-Drug Conjugates (ADCs)	Antibody-drug Conjugate/ADC Related; Cytoskeletal Signaling
	Glembatumumab vedotin (CDX-011) 是一种抗体活性小分子偶联物，Glembatumumab vedotin 具有强大的抗癌作用，可用于研究三阴性乳腺癌(TNBC)。
T72528	NSC243928 mesylate	HuR	Chromatin/Epigenetic
	NSC243928 mesylate 可与人类淋巴细胞抗原 6 (LY6) 结合，是细胞生长抑制剂，具有抗癌活性，以 LY6K 依赖性方式诱导三阴性乳腺癌细胞的细胞死亡。
T40891	ADTL-SA1215 ADTL-SA1215	Others	Others
	ADTL-SA1215 is a novel, highly selective small-molecule compound that acts as a specific activator of SIRT3, a protein known to play a crucial role in modulating autophagy. This compound holds great potential in the treatment of triple-negative breast cancer, as it effectively targets the molecular pathways associated with this subtype of cancer.
T32737	Liafensine BMS820836,BMS 820836,DB104,BMS-820836	Dopamine Receptor; 5-HT Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Liafensine(BMS-820836) 是一种新型且具有选择性的三重单胺再摄取抑制剂，对血清素、去甲肾上腺素和多巴胺的再摄取具有抑制作用，可用于研究重度抑郁症和中枢神经系统疾病。
T77759	GPX4-IN-6	GPX	oxidation-reduction
	GPX4-IN-6 是一种小分子共价 GPX4 抑制剂（IC50: 0.12 μM），具有抗肿瘤活性。GPX4-IN-6 可促使铁死亡，用于治疗=和预防三阴性乳腺癌 (TNBC)。
T62518	GRK6-IN-1	GRK	GPCR/G Protein
	GRK6-IN-1 是一种具有选择性和高效性的 G 蛋白偶联受体激酶 6 (GRK6) 抑制剂（IC50：120 nM）。GRK6-IN-1 具有研究多发性骨髓瘤和三阴性乳腺癌。
T5001	Nintedanib esylate Intedanib,乙磺酸尼达尼布,BIBF 1120 (esylate),尼达尼布乙磺酸盐,Nintedanib Ethanesulfonate Salt,BIBF 1120	VEGFR; FGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Nintedanib esylate (BIBF 1120 esylate) 是一种有效的三重血管激酶抑制剂，能够抑制 VEGFR1 (IC50:34 nM)、VEGFR2 (IC50:13 nM)、VEGFR3 (IC50:13 nM)，FGFR1 (IC50:69 nM)、FGFR2 (IC50:37 nM)、FGFR3 (IC50:108 nM)，PDGFRα (IC50:59 nM)、PDGFRβ (IC50:65 nM)。
T76279	Retatrutide LY3437943	Glucagon Receptor	GPCR/G Protein
	Retatrutide (LY3437943) 是胰高血糖素受体、葡萄糖依赖性促胰岛素多肽受体和胰高血糖素样肽-1 受体三重激动剂,对GCGR、GIPR 和 GLP-1R 具有抑制作用。Retatrutide 可用研究肥胖症。
T77342	GSK-3 inhibitor 3	GSK-3; Microtubule Associated	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
	GSK-3 inhibitor 3 是一种具有选择性、具有口服活性和脑渗透性的 GSK-3 抑制剂，对 GSK-3α 和 GSK-3β 具有抑制作用， IC50s 分别为 0.35 nM 和 0.25 nM。GSK-3 inhibitor 3 在三重转基因小鼠阿尔茨海默病模型中降低 Tau 蛋白 (tau protein) S396 磷酸化水平，IC50为 10 nM。GSK-3 inhibitor 3 可用于研究神经系统疾病。
T77755	GPX4-IN-5	GPX	oxidation-reduction
	GPX4-IN-5 是一种小分子共价 GPX4 抑制剂（IC50: 0.12 μM），具有抗肿瘤活性。GPX4-IN-5 可促使铁死亡，可用于预防和治疗三阴性乳腺癌 (TNBC)。
T11158	EGFR-IN-11	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-11 是 EGFR-酪氨酸激酶的选择性抑制剂，可诱导细胞凋亡。 EGFR-IN-11 抑制三重突变体 EGFRL858R/T790M/C797S，IC50 为 18 nM，并在 G0/G1 时阻止细胞周期。
T76279L1	Retatrutide sodium salt Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt	Glucagon Receptor	GPCR/G Protein
	Retatrutide sodium salt 是一种有效的胰高血糖素受体 (GCGR)、葡萄糖依赖性促胰岛素多肽受体 (GIPR) 和胰高血糖素样肽-1 受体 (GLP-1R) 的三重激动剂肽。Retatrutide sodium salt 可用于研究2型糖尿病和肥胖症。
T84314	BFC1108	Apoptosis	Apoptosis
	BFC1108 可靶向 Bcl-2 并将其转化为促凋亡蛋白，抑制Bcl-2高表达的三阴性乳腺癌异种移植物的生长，抑制乳腺癌肺转移，促使表达 Bcl-2 的癌症细胞凋亡。
T8325	SR-4835	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	SR-4835 是一种 ATP 竞争性的 CDK12/CDK13高选择性抑制剂。它与破坏 DNA 的化学疗法和 PARP 抑制剂协同作用，并引起三阴性乳腺癌细胞凋亡。
T14685	BMS-986158	Epigenetic Reader Domain	Chromatin/Epigenetic
	BMS-986158 是一种BET 抑制剂，在 MDA-MB231 三阴性乳腺癌细胞和 NCI-H211 小细胞肺癌细胞中，对 BET 的IC50分别为 5 和 6.6 nM。
T35528L	TD52 dihydrochloride TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl	Others	Others
	TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signaling pathway, resulting in the induction of apoptosis in triple-negative breast cancer (TNBC) cells. Mechanistically, TD52 dihydrochloride disrupts the binding of Elk1 to the CIP2A promoter, effectively reducing CIP2A levels. Notably, TD52 dihydrochloride demonstrates powerful anti...
T17206	UPGL00004	Others; Glutaminase	Others; Proteases/Proteasome
	UPGL00004 是一种有效的谷氨酰胺酶 C (GAC) 抑制剂，其 IC50为29 nM。UPGL00004 对 GAC 的 Kd 为27 nM。UPGL00004 对高度侵袭性三阴性乳腺癌细胞系的增殖具有很强的抑制作用。
T1777	Nintedanib BIBF 1120,Intedanib,尼达尼布	VEGFR; FGFR; FLT; PDGFR; Src	Angiogenesis; Tyrosine Kinase/Adaptors
	Nintedanib (Intedanib) 是一种三重血管激酶抑制剂，抑制 VEGFR1、VEGFR2、VEGFR3 (IC50=34/13/13 nM)，FGFR1、FGFR2、FGFR3 (IC50=69/37/108 nM)，PDGFRα、PDGFRβ (IC50=59/65 nM)。Nintedanib 具有抗肿瘤活性，通过抑制血管生成来抑制肿瘤生长。
T81490	PHI-101	Others	Others
	PHI-101是口服FLT3抑制剂，在克服多耐药突变方面表现出高效。该化合物对FLT3的ITD或TKD单突变体表现出显著抑制作用，同时也能抑制包括双重（ITD/D835Y或ITD/F691L）和三重（ITD/D835Y/F691L）耐药突变。PHI-101在治疗复发或难治性急性髓系白血病（AML）的研究中显示出应用潜力。
T3097	Mycophenolic Acid Impurity 马替麦考酚酸杂质,5,7-dihydroxy-4-methylphthalide	Others	Others
	Mycophenolic Acid Impurity (5,7-dihydroxy-4-methylphthalide) 是一种免疫抑制药物和有效的抗增殖剂，可用于代替旧的抗增殖剂 azathioprine。它通常用作三联疗法的一部分，包括钙调神经磷酸酶抑制剂（ciclosporin 或 tacrolimus）和prednisolone。它还可用于研究选择表达编码 XGPRT（黄嘌呤鸟嘌呤磷酸核糖基转移酶）的大肠杆菌基因的动物细胞。
T10534	BI-4020	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BI-4020 是一种第四代，口服有效，非共价的 EGFR 酪氨酸激酶抑制剂。BI-4020 表现出对三联突变的 EGFR del19 T790M C797S 突变体 ( BaF3 细胞系，IC50=0.2 nM)，双重突变的 EGFR del19 T790M 以及单突变的 EGFR del19 (IC50=1 nM)的抑制剂活性。BI-4020 保留了抑制 EGFR wt 的活性 (IC50=190 nM)。BI-4020 具有高激酶组选择性和良好的 DMPK 性质。
T62077	VT103 VT-103,VT 103	YAP	Stem Cells
	VT103 是一种具有口服活性和选择性的 TEAD1 蛋白棕榈酰化抑制剂，是 VT101 的类似物。 VT103 有潜在的抗肿瘤活性，可抑制 YAP/TAZ-TEAD 促进的基因转录，阻断 TEAD auto-palmitoylation，阻断 YAP/TAZ和TEAD 之间的相互作用。VT103 可用于研究HER2阳性乳腺癌、前列腺癌和三阴性乳腺癌。
T77341	GSK-3 inhibitor 4	GSK-3; CDK	Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	GSK-3 inhibitor 4 是一种具有口服活性和脑渗透性的 GSK-3，CDK2 和 CDK5 三重抑制剂，对 GSK-3β，GSK-3α，CDK2 和 CDK5 具有抑制作用，IC50 值分别为 0.56 nM ，0.45 nM ，0.47 μM，0.68 μM。GSK-3 inhibitor 4 可有效降低 Tau protein 水平。GSK-3 inhibitor 4 可用于研究阿尔茨海默症。
T11600	IBR2 Isoquinoline	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	IBR2（Isoquinoline）是一种针对RAD51的强效特异性抑制剂，通过干预RAD51多聚体形成，加速蛋白酶体介导的RAD51蛋白降解，抑制癌细胞生长并诱导凋亡。实验证明在抑制RAD51介导的DNA双链断裂修复方面有效。
T25467	GSK1360707 GSK-1360707,GSK 1360707	Others	Others
	GSK1360707 is a selective triple reuptake inhibitor (TRI).
T69852	CS-003 HCl	Others	Others
	CS-003 HCl is a TNRA - triple neurokinin receptor antagonist.
T38839	MCX 28	Others	Others
	MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.
T25232	CGS 35601 CGS-35601,CGS35601	Others	Others
	CGS 35601 is a single molecule inhibitor of triple vasopeptidase.
T70341	D-473	Others	Others
	D-473 is a novel orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters.

化合物

Cat.No: T9407

Target: Others, Ras

Cat.No: T9468

Target: Others

Cat.No: T41256

Target: Aurora Kinase

Cat.No: T10860

Target: HSP

Cat.No: T13780

Target: Apoptosis, Histone Methyltransferase

Cat.No: T6797

Synonym: CB 839,CB839,CB-839

Target: transporter, Glutaminase, Autophagy

Cat.No: T13044

Synonym: SY-1365

Target: CDK

Cat.No: T19664

Synonym: GBO-006

Target: Apoptosis, PLK

Cat.No: T7530

Synonym: NSC168807

Target: Ferroptosis, Lipoxygenase, Autophagy

Cat.No: T2655

Synonym: CEP37440

Target: FAK, ALK

Cat.No: T9320

Synonym: B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid

Target: Sirtuin

LYN-1604 dihydrochloride

Cat.No: T8808L

Synonym: LYN-1604 2HCl（2216753-86-3 free base)

Target: Apoptosis, Autophagy

Cat.No: T4123

Synonym: LYN1604

Target: Apoptosis, Autophagy

Cat.No: T35528

Target: Apoptosis, Phosphatase, Akt

Amitifadine hydrochloride

Cat.No: T2092

Synonym: DOV-21947 hydrochloride,EB-1010 hydrochloride

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine

Cat.No: T70353

Target: HSP

Cat.No: T8569

Target: mTOR

Cat.No: T6224

Synonym: NSC-746045,IND-71677,3-硝基-4-碘苯甲酰胺,BSI-201

Target: PARP, Influenza Virus

Cat.No: T7296

Synonym: CDK7-IN-1

Target: CDK

Cat.No: T9583

Synonym: N-Acetylphenoxazine,10-acetylphenoxazine

Target: Pim

Dasotraline hydrochloride

Cat.No: T3526

Synonym: SEP-225289 hydrochloride,达索曲林盐酸盐

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine

Glembatumumab vedotin

Cat.No: T74178

Synonym: CR011-vcMMAE,CR 011 ADC,CDX-011

Target: Microtubule Associated, Antibody-Drug Conjugates (ADCs)

NSC243928 mesylate

Cat.No: T72528

Target: HuR

Cat.No: T40891

Synonym: ADTL-SA1215

Target: Others

Cat.No: T32737

Synonym: BMS820836,BMS 820836,DB104,BMS-820836

Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine

Cat.No: T77759

Target: GPX

Cat.No: T62518

Target: GRK

Nintedanib esylate

Cat.No: T5001

Synonym: Intedanib,乙磺酸尼达尼布,BIBF 1120 (esylate),尼达尼布乙磺酸盐,Nintedanib Ethanesulfonate Salt,BIBF 1120

Target: VEGFR, FGFR, PDGFR

Cat.No: T76279

Synonym: LY3437943

Target: Glucagon Receptor

GSK-3 inhibitor 3

Cat.No: T77342

Target: GSK-3, Microtubule Associated

Cat.No: T77755

Target: GPX

Cat.No: T11158

Target: EGFR

Retatrutide sodium salt

Cat.No: T76279L1

Synonym: Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt

Target: Glucagon Receptor

Cat.No: T84314

Target: Apoptosis

Cat.No: T8325

Target: Apoptosis, CDK

Cat.No: T14685

Target: Epigenetic Reader Domain

TD52 dihydrochloride

Cat.No: T35528L

Synonym: TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl

Target: Others

Cat.No: T17206

Target: Others, Glutaminase

Cat.No: T1777

Synonym: BIBF 1120,Intedanib,尼达尼布

Target: VEGFR, FGFR, FLT, PDGFR, Src

Cat.No: T81490

Target: Others

Mycophenolic Acid Impurity

Cat.No: T3097

Synonym: 马替麦考酚酸杂质,5,7-dihydroxy-4-methylphthalide

Target: Others

Cat.No: T10534

Target: EGFR

Cat.No: T62077

Synonym: VT-103,VT 103

Target: YAP

GSK-3 inhibitor 4

Cat.No: T77341

Target: GSK-3, CDK

Cat.No: T11600

Synonym: Isoquinoline

Target: DNA/RNA Synthesis

Cat.No: T25467

Synonym: GSK-1360707,GSK 1360707

Target: Others

Cat.No: T69852

Target: Others

Cat.No: T38839

Target: Others

Cat.No: T25232

Synonym: CGS-35601,CGS35601

Target: Others

Cat.No: T70341

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2896	Alantolactone 土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor	Apoptosis; STAT; TGF-beta/Smad	Apoptosis; JAK/STAT signaling; Stem Cells
	Alantolactone (Inula camphor) 是一种STAT3的选择性抑制剂，可诱导癌症相关的凋亡，具有抗肿瘤活性。
T7979	2-Hydroxychalcone 2-(2-Hydroxybenzal)Acetophenone,2-羟基查酮	Apoptosis; BCL; Others; NF-κB	Apoptosis; NF-κB; Others
	2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) 是一种天然黄酮，可通过下调 Bcl-2 诱导凋亡，也可抑制NF-kB 的激活。它是抗氧化剂，抑制脂质过氧化，还可抑制三阴性乳腺癌细胞的侵袭。
T6S1683	Demethoxycurcumin Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin	Apoptosis; Antioxidant; Antibacterial; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; oxidation-reduction
	Demethoxycurcumin (Desmethoxycurcumin) 是姜黄素的主要活性成分，有抗炎和抗癌作用。
T21771	Pyoluteorin	Antibiotic	Microbiology/Virology
	Pyoluteorin 是一种抗生素 (antibiotic)，可抑制 Oomycete fungi，包括植物病原体 Oomycete fungi，并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。
T3418	Demethylzeylasteral 去甲泽拉木醛,Demethylzeylasteral (T-96)	Apoptosis; UGT	Apoptosis; Metabolism
	Demethylzeylasteral (Demethylzeylasteral (T-96)) 分离自雷公藤，具有抗炎、免疫抑制和抗肿瘤活性。它通过阻断 TGF-β 信号通路，抑制三阴性乳腺癌的侵袭，它能显著减轻动脉粥样硬化。
T65135	Kynurenic acid Fibrostop 2,Quinurenic acid	GPR; GluR; NMDAR	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Kynurenic acid (Quinurenic acid) 是一种内源性色氨酸活性代谢物，是一种 NMDA, glutamate, α7 nicotinic acetylcholine receptor 三重拮抗剂，也是 GPR35/CXCR8 激动剂，具有神经保护和抗惊厥特性，可用于研究神经分裂和与代谢相关的疾病。
T37512	cis-4-Hydroxy-L-proline	Endogenous Metabolite	Metabolism
	cis-4-Hydroxy-L-proline 是脯氨酸的一种类似物，抑制胶原蛋白的产生。它通过阻止三层螺旋胶原在细胞层上的沉积从而抑制成纤维细胞的生长。它还可抑制原发性N-亚硝基甲基脲诱导的大鼠乳腺肿瘤的生长。
T25596	Lactiflorasyne
	Lactiflorasyne is a bioactive chemical from Artemisia lactiflora Wall that contains an ester group, a spiro system and two triple bonds.
TN2691	2',3'-Dehydrosalannol	BCL; Akt; Caspase	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), it inhibits cathepsin-mediated pro-survival signaling which resulted in growth arrest of TNBC cells.

天然产物

Cat.No: T2896

Synonym: 土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor

Target: Apoptosis, STAT, TGF-beta/Smad

2-Hydroxychalcone

Cat.No: T7979

Synonym: 2-(2-Hydroxybenzal)Acetophenone,2-羟基查酮

Target: Apoptosis, BCL, Others, NF-κB

Demethoxycurcumin

Cat.No: T6S1683

Synonym: Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin

Target: Apoptosis, Antioxidant, Antibacterial, Autophagy

Cat.No: T21771

Target: Antibiotic

Demethylzeylasteral

Cat.No: T3418

Synonym: 去甲泽拉木醛,Demethylzeylasteral (T-96)

Target: Apoptosis, UGT

Cat.No: T65135

Synonym: Fibrostop 2,Quinurenic acid

Target: GPR, GluR, NMDAR

cis-4-Hydroxy-L-proline

Cat.No: T37512

Target: Endogenous Metabolite

Cat.No: T25596

2',3'-Dehydrosalannol

Cat.No: TN2691

Target: BCL, Akt, Caspase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01395	CTHRC1 Protein, Human, Recombinant (His) collagen triple helix repeat containing 1	Human	HEK293 Cells
	CTHRC1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.5 kDa and the accession number is Q96CG8-1.
TMPY-06775	CTHRC1 Protein, Human, Recombinant (hFc) collagen triple helix repeat containing 1	Human	HEK293 Cells
	CTHRC1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.8 kDa and the accession number is NP_612464.1.
TMPY-06795	CTHRC1 Protein, Mouse, Recombinant (His) 1110014B07Rik,collagen triple helix repeat containi...	Mouse	HEK293 Cells
	CTHRC1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.53 kDa and the accession number is Q9D1D6.
TMPY-04288	CTHRC1 Protein, Rat, Recombinant (His) collagen triple helix repeat containing 1	Rat	HEK293 Cells
	CTHRC1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.8 kDa and the accession number is NP_001258229.1.
TMPY-06826	CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated collagen triple helix repeat containing 1	Human	HEK293 Cells
	CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 26.33 kDa and the accession number is NP_612464.1.
TMPH-01123	CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc) Collagen triple helix repeat-containing protein 1,C...	Human	HEK293 Cells
	May act as a negative regulator of collagen matrix deposition. CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc) is expressed in HEK293 mammalian cells with C-hFC tag. The predicted molecular weight is 52 kDa and the accession number is Q96CG8.
TMPH-02592	CTHRC1 Protein, Mouse, Recombinant (aa 33-245, His) Collagen triple helix repeat-containing protein 1,C...	Mouse	HEK293 Cells
	May act as a negative regulator of collagen matrix deposition.
TMPH-02593	CTHRC1 Protein, Mouse, Recombinant (His & SUMO) Collagen triple helix repeat-containing protein 1,C...	Mouse	E. coli
	May act as a negative regulator of collagen matrix deposition.
TMPH-01455	Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Triplex capsid protein 1 (His) Triplex capsid protein 1,TRX1	HHV-6A	E. coli
	Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Triplex capsid protein 1 (His) is expressed in E. coli.
TMPY-04817	Syntenin Protein, Human, Recombinant (His) MDA-9,SYCL,TACIP18,syndecan binding protein (syntenin),ST1,M...	Human	E. coli
	Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domain-containing molecule, which was initially identified as a key oncogene in melanoma. IL-6 promotes glioma cell proliferation and invasion by inducing SDCBP expression, which is mediated by JAK2/STAT3 signaling. SDCBP might be an important marker for identifying Triple negative breast cancer (TNBC) cases that are suitable for dasatinib therapy.
TMPH-02342	Collagenase Protein, Hypoderma lineatum, Recombinant (His & Myc) Collagenase,HC,Hypodermin C	Hypoderma lineatum	E. coli
	This enzyme is a serine protease capable of degrading the native triple helix of collagen. Also cleaves the B chain of insulin at the 15-Leu-\|-Try-16 and 22-Arg-\|-Gly-23 bonds. Hydrolyzes casein, but not Px-Pro-Leu-Gly-Pro-DArg, BzArgNHPh, AcTyrNHPh, 2-naphthyl phosphate, 2-naphthyl butyrate, 2-naphthyl caprylate, 2-naphthyl myristate, L-leucine 2-2-naphthylamide, L-valine 2-naphthylamide, L-cysteine 2-naphthylamide or L-glutarylphenylalanine 2-naphthylamide.
TMPY-03272	COL4A3 Protein, Rat, Recombinant (hFc) collagen, type IV, α3 (Goodpasture antigen),collagen, type I...	Rat	HEK293 Cells
	COL4A3 is a major structural component of basement membranes. It is composed of 3 alpha subunits, which are encoded by 6 different genes, alpha 1 through alpha 6. Each of these alpha subunits can form a triple helix structure with 2 other subunits to form COL4A3. Autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli can cause goodpasture syndrome. COL4A3 is also linked to an autosomal recessive form of alport syndrome. COL4A3 is organized in a he...
TMPY-03809	COL5A2 Protein, Human, Recombinant (mFc) collagen, type V, α2,collagen, type V, alpha 2	Human	HEK293 Cells
	COL5A2 is a component of type V collagen. It is known as the pro-alpha2(V) chain. COL5A2, together with two pro-alpha1(V) chains can form type V procollagen. These triple-stranded, rope-like procollagen molecules arrange themselves into long, thin fibrils that cross-link to one another in the spaces around cells. The cross-links result in the formation of very strong, mature type V collagen fibers. Type V collagen can be detected in tissues containing type I collagen and appears to regulate the ...
TMPH-00419	Microbial collagenase Protein, Clostridium perfringens, Recombinant (His & Myc) 120 kDa collagenase,colA,Collagenase ColA,Microbial collagen...	C.perfringens	E. coli
	Clostridial collagenases are among the most efficient degraders of eukaryotic collagen known; saprophytes use collagen as a carbon source while pathogens additionally digest collagen to aid in host colonization. Has both tripeptidylcarboxypeptidase on Gly-X-Y and endopeptidase activities; the endopeptidase cuts within the triple helix region of collagen while tripeptidylcarboxypeptidase successively digests the exposed ends, thus clostridial collagenases can digest large sections of collagen. Mi...
TMPJ-00133	MBL2 Protein, Mouse, Recombinant Mannose binding lectin (C),MBL-2,Mannose-binding protein C,M...	Mouse	HEK293 Cells
	Mannose-binding Lectin (MBL) is an acute phase protein bearing to the family of collectins produced by the liver as a monomer that forms a triple helix. Once released in serum, it further polymerizes forming dimers to octamers. The degree of serum polymerization is critical for the biological activity of MBL. MBL has higher affinity to microbial polysaccharides or their glycoconjugates. MBL was shown earlier to bind cell surfaces of bacteria, fungi, protozoa and viruses and acts as an acute-phas...
TMPH-02594	MMP-13 Protein, Mouse, Recombinant (His) Matrix metalloproteinase-13,Collagenase 3,Mmp13	Mouse	E. coli
	Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone develop...
TMPJ-00804	COL3A1 Protein, Mouse, Recombinant (His) Col3a1,Collagen alpha-1(III) chain,Collagen α-1(III) chain	Mouse	HEK293 Cells
	Collagen alpha-1(III) chain（Col3a1） is a secreted protein and belongs to the fibrillar collagen family.It contains 1 fibrillar collagen NC1 domain and 1 VWFC domain. Collagen alpha-1(III) chain is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I collagen. The COL3A1 gene produces the components of type III collagen, called pro-alpha1(III) chains. Three copies of this chain combine to make a mole...

重组蛋白

CTHRC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01395

Species: Human

Expression System: HEK293 Cells

CTHRC1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-06775

Species: Human

Expression System: HEK293 Cells

CTHRC1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06795

Species: Mouse

Expression System: HEK293 Cells

CTHRC1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04288

Species: Rat

Expression System: HEK293 Cells

CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06826

Species: Human

Expression System: HEK293 Cells

CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc)

Cat.No: TMPH-01123

Species: Human

Expression System: HEK293 Cells

CTHRC1 Protein, Mouse, Recombinant (aa 33-245, His)

Cat.No: TMPH-02592

Species: Mouse

Expression System: HEK293 Cells

CTHRC1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02593

Species: Mouse

Expression System: E. coli

Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Triplex capsid protein 1 (His)

Cat.No: TMPH-01455

Species: HHV-6A

Expression System: E. coli

Syntenin Protein, Human, Recombinant (His)

Cat.No: TMPY-04817

Species: Human

Expression System: E. coli

Collagenase Protein, Hypoderma lineatum, Recombinant (His & Myc)

Cat.No: TMPH-02342

Species: Hypoderma lineatum

Expression System: E. coli

COL4A3 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03272

Species: Rat

Expression System: HEK293 Cells

COL5A2 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03809

Species: Human

Expression System: HEK293 Cells

Microbial collagenase Protein, Clostridium perfringens, Recombinant (His & Myc)

Cat.No: TMPH-00419

Species: C.perfringens

Expression System: E. coli

MBL2 Protein, Mouse, Recombinant

Cat.No: TMPJ-00133

Species: Mouse

Expression System: HEK293 Cells

MMP-13 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02594

Species: Mouse

Expression System: E. coli

COL3A1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00804

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0181	Demethoxy Curcumin-d4
	Demethoxy Curcumin-d4 是 Demethoxy Curcumin 的氘代化合物。Demethoxy Curcumin 的 CAS 号为 22608-11-3。Demethoxycurcumin是姜黄素的主要活性成分，有抗炎和抗癌作用。

同位素标记化合物

Demethoxy Curcumin-d4

Cat.No: TMIH-0181

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