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Search Results for " therapies "

Targets Recommended: DNA Methyltransferase

36

抑制剂 & 化合物

2

天然产物

13

化合物库

15

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L2170	肿瘤免疫治疗小分子化合物库		449 compounds
	449 种靶向肿瘤免疫治疗靶点的小分子，可用于高通量和高内涵筛选，是研究肿瘤免疫治疗的有力工具；
L3900	DNA 损伤和修复分子库		910 compounds
	910 个与 DNA 损伤和修复紧密相关的化合物集合，是高通量筛选，高内涵筛选的良好载体；
L9840	抗阿尔茨海默症化合物库		986 compounds
	986 种阿尔茨海默症相关的化合物集合，可用于高通量和高内涵筛选；
L2190	抗肺癌化合物库		1702 compounds
	1702 种与肺癌相关的化合物，可以用于抗肺癌药物研发和药理研究；
L3980	DNA损伤/修复库Plus		667 compounds
	667 种 DNA 损伤/修复靶向、结构新颖的化合物；
L4800	血管生成库		1353 compounds
	1353 个高潜力的抑制或促进血管生成的小分子集合，可用于药物靶点开发、血管生成机理研究的高通量筛选，高内涵筛选；
L2196	抗卵巢癌化合物库		1867 compounds
	1867 种与卵巢癌相关的化合物，可以用于抗卵巢癌药物研发和药理研究
L8000	干细胞分化化合物库		1197 compounds
	1197 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合，可用于高通量、高内涵筛选；
L6110	生物碱类天然产物库		500 compounds
	500 种生物碱类天然产物的独特集合，可用于高通量筛选和高内涵筛选；
L8400	血液病分子库		514 compounds
	514 种造血系统疾病相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L9420	外泌体相关化合物库		76 compounds
	76 种外泌体相关的化合物，可以用于高通量和高内涵筛选；
L2540	肠道微生物代谢化合物库		614 compounds
	614 种肠道微生物代谢物的集合，可以用于高通量和高内涵筛选；
L6500	微生物天然产物库		685 compounds
	685 种微生物来源的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

肿瘤免疫治疗小分子化合物库

Cat.No: L2170

Compounds: 449

DNA 损伤和修复分子库

Cat.No: L3900

Compounds: 910

抗阿尔茨海默症化合物库

Cat.No: L9840

Compounds: 986

抗肺癌化合物库

Cat.No: L2190

Compounds: 1702

DNA损伤/修复库Plus

Cat.No: L3980

Compounds: 667

血管生成库

Cat.No: L4800

Compounds: 1353

抗卵巢癌化合物库

Cat.No: L2196

Compounds: 1867

干细胞分化化合物库

Cat.No: L8000

Compounds: 1197

生物碱类天然产物库

Cat.No: L6110

Compounds: 500

血液病分子库

Cat.No: L8400

Compounds: 514

外泌体相关化合物库

Cat.No: L9420

Compounds: 76

肠道微生物代谢化合物库

Cat.No: L2540

Compounds: 614

微生物天然产物库

Cat.No: L6500

Compounds: 685

Cat. No.	Product Name	Target	Signaling Pathways
T11469	GSK-3484862	DNA Methyltransferase	Chromatin/Epigenetic
	GSK-3484862 是有效的 DNA 甲基转移酶 Dnmt1的非共价抑制剂。GSK-3484862 通过诱导 DNA 低甲基化起抗癌作用。GSK-3484862 介导小鼠胚胎干细胞的整体去甲基化。
T77614	DpC	Others	Others
	DPC 是一种抗肿瘤化合物，对癌细胞增殖有抑制作用，IC50为 0.007-0.096 μM。DPC 可参与多种抗癌疗法，可用于研究癌症。
T8839	ICCB280	Apoptosis; Others	Apoptosis; Others
	ICCB280 是一种 C/EBPα诱导剂，通过激活 C/EBPα 并影响其下游靶点，具有终末分化、增殖停滞和凋亡的抗白血病特性。
T3625	Bempedoic acid ETC1002,ESP-55016,ETC 1002,ETC-1002	ATP Citrate Lyase; AMPK	Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling
	Bempedoic acid (ETC1002) 是一种 ATP-柠檬酸裂解酶抑制剂，可激活AMPK。它是脂质和碳水化合物代谢的调节剂。
T9498	BAY-8400	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	BAY-8400是一种具有口服活性、有效和选择性 DNA 依赖蛋白激酶 (DNA-PK) 抑制剂(IC50=81 nM)，与靶向α疗法联合使用显示协同疗效。BAY-8400 可用于癌症研究。
T3579	PLX8394	Raf	MAPK
	PLX8394 是一种口服活性的丝氨酸/苏氨酸蛋白激酶 B-Raf (BRAF) 蛋白抑制剂。 PLX8394 可以选择性地结合并抑制野生型和突变形式的 BRAF 的活性，然后抑制表达 BRAF 突变形式的肿瘤细胞的增殖。 PLX8394 似乎对表达多种激酶突变形式的肿瘤有效，并且可能是对其他对 BRAF V600E 突变体特异的 BRAF 抑制剂疗法耐药的肿瘤的有效治疗剂。
T27497	GSK-982 GSK 982,GSK982	Others	Others
	GSK-982, an opioid receptor antagonist, has activity as potential therapies for obesity.
T30236L	Axelopran sulfate	Others	Others
	Axelopran sulfate is used in Oral Therapies for Opioid-induced Bowel Dysfunction in Patients with Chronic Noncancer Pain.
T40166	Bexirestrant	Others	Others
	Bexirestrant is an orally active ER-α degrader commonly employed in the research of antiestrogen and antineoplastic therapies.
T71865	DSM43	Others	Others
	DSM43 is a dihydroorotate dehydrogenase (DHODH) inhibitor. Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target for malaria treatmen
T71245	ARRY-502	Others	Others
	ARRY-502 is a CRTH2 antagonist. Regulation of cytokine activity is important in molecularly targeted therapies for asthma.
T74337	DNA crosslinker 1 dihydrochloride	Others	Others
	DNA crosslinker 1 (dihydrochloride)作为有效DNA小沟结合剂,具有1.1°C的结合亲和力（ΔTm），适用于抗癌研究。
T70847	BMS-351	Others	Others
	BMS-351 is a potent and selective, nonsteroidal CYP17A1 lyase inhibitor with robust selectivity over steroidogenic CYPs 21A2 and 11B1. BMS-351 emerges as an outstanding preclinical candidate to treat CRPC and is likely to minimize the side effects of current therapies due to its exceptional selectivity. BMS-351 is potentially useful for the Treatment of Prostate Cancer.
T82296	GluN1(359-378)
	GluN1(359-378)为抗N-甲基-D-天冬氨酸受体(NMDAR)抗体，具有穿透血脑屏障的能力。该化合物主要应用于抗NMDAR脑炎治疗的免疫系统研究。
T74879	306-N16B	Others	Others
	306-N16B 是一种脂质纳米颗粒，可实现 Cas9 mRNA 和 sgRNA 的系统性协同递送。306-N16B 可将 mRNA 转运至肺内皮细胞。306-N16B 可用于基因组编辑疗法的研究。
T79340	GLS1 Inhibitor-7	Glutaminase	Proteases/Proteasome
	GLS1 Inhibitor-7 (compound 4d) 作为一种GLS1 抑制剂，表现出抑制浓度50%所需浓度（IC50）为46.7 μM，潜在用途涉及抗癌、抗衰老和抗肥胖。
T68346	KRN383	Others	Others
	KRN383 also inhibited the proliferation of the ITD-positive cell lines with IC(50) values of < or =2.9 nM. A single oral administration of 80 mg/kg of KRN383 eradicated ITD-positive xenograft tumors in nude mice and prolonged the survival of SCID mice carrying ITD-positive AML cells. The effectiveness of a single oral dose of KRN383 suggests that it has the potential to be used in a wide variety of clinical regimens, including multicycle and combination therapies.
T69776	BAY-707 acetate	Others	Others
	BAY-707 is a substrate-competitive, highly potent and selective inhibitor of MTH1. Despite superior cellular target engagement and pharmacokinetic properties, inhibition of MTH1 with BAY-707 resulted in a clear lack of in vitro or in vivo anticancer efficacy either in mono- or in combination therapies.
T84747	(R,S,S)-VH032	Others	Others
	(R,S,S)-VH032 为E3 Ligase用于PROTACs合成的Ligand。作为VHL配体及VHL/HIF-1α相互作用抑制剂，该化合物用于募集von Hippel-Lindau (VHL)蛋白，进而可合成针对tau的小分子PROTACC004019。
T38910	mGluR2 antagonist 1	Others	Others
	mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, with an IC50 value of 9 nM. Furthermore, it exhibits excellent permeability across the blood-brain barrier, making it a promising candidate for central nervous system-related studies or therapies.
T79136	DGKζ-IN-1	Others	Others
	DGKζ-IN-1（化合物9）是一种DGKζ的抑制剂，用于研究与免疫细胞激活相关的癌症或对抗PD-1抗体/抗PD-L1抗体耐药的癌症。
T78520	CYT296	Others	Others
	CYT296是一种靶向染色质去凝集的化合物，能增强定义因子(OSKM)介导诱导多能干细胞(iPSC)的生成，并通过诱导小鼠胚胎成纤维细胞(MEFs)染色质的开放状态来促进体细胞的重编程，适用于细胞替代治疗和药物筛选的研究领域。
T71467	Nemorubicin HCL	Others	Others
	Nemorubicin HCL is the salt form of Nemorubicin, also known as PNU152243A, a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. It works primarily through topoisomerase I inhibition. Of note, Nemorubicin is active in cells with upregulation of the nucleotide excision repair (NER) pathway...
T80578	Evunzekibart ATOR-1017
	Evunzekibart (ATOR-1017)是一种以Fc-γ受体为条件的4-1BB激动剂，属于IgG4亚型抗体。该化合物既可以作为单药疗法，也可与抗PD1治疗相结合，以发挥其抗肿瘤效果。
T18522	PC Mal-NHS carbonate ester	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	PC Mal-NHS carbonate ester is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. This chemical compound plays a crucial role in facilitating the conjugation of drugs to antibodies, enabling targeted delivery and enhanced efficacy of therapeutic agents. Its unique carbonate ester structure allows for efficient cleavage in the targeted environment, ensuring the controlled release of the drug payload. Its application in ADC synthesis highlights its imp...
T79051	PCSK9-IN-15	Others	Others
	PCSK9-IN-15（化合物5）是一种高效PCSK9抑制剂，亲和力强（KD<200 nM）。该化合物与胆固醇代谢相关，可调控低密度脂蛋白胆固醇（LDL-C）水平，适用于研究降低胆固醇及血脂异常。
T70352	PH11	Others	Others
	PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT pathways. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL...
T30807	CG0009 CG-0009,CG 0009	Others	Others
	CG0009 is a potent and highly selective glycogen synthase kinase 3 (GSK3) inhibitor that inhibitions proliferation, induces apoptosis, and activates the p53-Bax pathway in breast cancer cells through cyclin D1 depletion. CG0009 inhibit breast cancer cell
T71578	Endoxifen mesylate	Others	Others
	Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is a chemical that is under development for estrogen receptor-positive breast cancer. It is also being evaluated as an antipsychotic for treatment of mania and other psychotic disorders. Endoxifen is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group. It is an active metabolite of tamoxifen and has been found to be effective in patients that have failed previous hormonal therapies (tamoxifen, aromat...
T78528	ERX-41	Others	Others
	ERX-41是一种口服活性的立体特异性小分子，靶向溶酶体酸性脂肪酶A (LIPA)。该化合物通过诱导内质网(ER)应激从而导致细胞死亡，这一作用表明ERX-41功能独立于LIPA，但依赖于其在内质网的定位。ERX-41主要用于实体瘤靶向研究。
T72259	3-Chlorogentisyl alcohol	Others	Others
	3-Chlorogentisyl alcohol 是一种有效的 E. coliβ-葡萄糖醛酸酶β-glucuronidase 抑制剂，IC50值为 0.74 µM，Ki 值为 0.58 µM。3-Chlorogentisyl alcohol 显示出抗增殖活性。3-Chlorogentisyl alcohol 具有抗癌和抗炎治疗研究的潜力。
T31828	AZD4694 Flutafuranol,AZD 4694,NAV-4694,AZD-4694,NAV 4694,NAV4694	Others	Others
	Flutafuranol, also known as AZD 4694 and NAV4694, is a bio-active chemical. AZD4694 shows high affinity for beta-amyloid fibrils in vitro (K(d) = 2.3 +/- 0.3 nM). The fluorine-18 labeled AZD4694 may have potential for PET-visualization of cerebral beta-am
T69831	RPR-200765A Mesylayte	Others	Others
	RPR-200765A is a potent and selective inhibitor of p38 MAP kinase (IC50 = 50 nM). It inhibits LPS-stimulated TNFalpha release both in vitro, from human monocytes (EC50 = 110 nM), and in vivo in Balb/c mice (ED50 = 6 mg/kg). At oral doses between 10 and 30 mg/kg/day it reduces the incidence and progression in the rat streptococcal cell wall (SCW) arthritis model when administered in either prophylactic or therapeutic dosing regimens. The compound, which is a mesylate salt and exists as a stable m...
T84686	(S)-Sabutoclax (S)-BI-97C1	Others	Others
	(S)-Sabutoclax ((S)-BI-97C1) 作为一种光学纯的阿朴棉酚衍生物，对抗凋亡B细胞淋巴瘤/白血病2 (Bcl-2) 家族蛋白展现了全谱抑制作用。该化合物通过阻断BH3肽与Bcl-XL、Bcl-2、Mcl-1及Bfl-1的结合，展示出相应的IC50值为0.31、0.32、0.20及0.62 μM。此外，(S)-Sabutoclax还能有效抑制人类前列腺癌、肺癌以及淋巴瘤细胞系的生长，其EC50值分别为0.13、0.56及0.049 μM。因此，(S)-Sabutoclax对于基于细胞凋亡机制的癌症治疗研究具有重要价值。
T37736	N-cis-hexadec-9Z-enoyl-L-Homoserine lactone N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of whic...
T37741	N-hexadecanoyl-L-Homoserine lactone C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which...

化合物

Cat.No: T11469

Target: DNA Methyltransferase

Cat.No: T77614

Target: Others

Cat.No: T8839

Target: Apoptosis, Others

Cat.No: T3625

Synonym: ETC1002,ESP-55016,ETC 1002,ETC-1002

Target: ATP Citrate Lyase, AMPK

Cat.No: T9498

Target: DNA-PK

Cat.No: T3579

Target: Raf

Cat.No: T27497

Synonym: GSK 982,GSK982

Target: Others

Axelopran sulfate

Cat.No: T30236L

Target: Others

Cat.No: T40166

Target: Others

Cat.No: T71865

Target: Others

Cat.No: T71245

Target: Others

DNA crosslinker 1 dihydrochloride

Cat.No: T74337

Target: Others

Cat.No: T70847

Target: Others

Cat.No: T82296

Cat.No: T74879

Target: Others

GLS1 Inhibitor-7

Cat.No: T79340

Target: Glutaminase

Cat.No: T68346

Target: Others

BAY-707 acetate

Cat.No: T69776

Target: Others

Cat.No: T84747

Target: Others

mGluR2 antagonist 1

Cat.No: T38910

Target: Others

Cat.No: T79136

Target: Others

Cat.No: T78520

Target: Others

Nemorubicin HCL

Cat.No: T71467

Target: Others

Cat.No: T80578

Synonym: ATOR-1017

PC Mal-NHS carbonate ester

Cat.No: T18522

Target: Others, ADC Linker

Cat.No: T79051

Target: Others

Cat.No: T70352

Target: Others

Cat.No: T30807

Synonym: CG-0009,CG 0009

Target: Others

Endoxifen mesylate

Cat.No: T71578

Target: Others

Cat.No: T78528

Target: Others

3-Chlorogentisyl alcohol

Cat.No: T72259

Target: Others

Cat.No: T31828

Synonym: Flutafuranol,AZD 4694,NAV-4694,AZD-4694,NAV 4694,NAV4694

Target: Others

RPR-200765A Mesylayte

Cat.No: T69831

Target: Others

Cat.No: T84686

Synonym: (S)-BI-97C1

Target: Others

N-cis-hexadec-9Z-enoyl-L-Homoserine lactone

Cat.No: T37736

Synonym: N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone

Target: Others

N-hexadecanoyl-L-Homoserine lactone

Cat.No: T37741

Synonym: C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T82046	Irisquinone
	Irisquinone，一种具有抗癌活性的天然产物，同时作为癌症放射增敏剂。该化合物通过降低GSH水平并抑制DNA单链断裂修复，展现其药理作用。
T37291	Lyso-Globotriaosylceramide (d18:1) Lyso-Globotriaosylceramide (d18:1)	Others	Others
	Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas...

天然产物

Cat.No: T82046

Lyso-Globotriaosylceramide (d18:1)

Cat.No: T37291

Synonym: Lyso-Globotriaosylceramide (d18:1)

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05822	Hepatitis B Virus (HBV)(ayw/France/Tiollais/1979) Capsid protein (His)	HBV-D	E. coli
	Hepatitis B virus (HBV) capsid assembly is a critical step in the propagation of the virus and is mediated by the core protein. The first cytoplasmic step in the formation of an infectious HBV virion is the formation of a capsid containing pregenomic RNA (pgRNA) and the viral polymerase (Pol). HBV capsid assembly is an attractive target for new antiviral therapies.
TMPY-04483	IRAK4 Protein, Human, Recombinant (His) IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...	Human	Baculovirus Insect Cells
	Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ...
TMPK-01081	Glypican 2/GPC2 Protein, Mouse, Recombinant (His) Cerebroglycan,2410016G05Rik,GPC2,Glypican-2	Mouse	HEK293 Cells
	Glypicans can function as coreceptors for multiple signaling molecules known for regulating cell growth, motility, and differentiation. Some members of the glypican family, including glypican 2 (GPC2) and glypican 3 (GPC3), are expressed in childhood cancers and liver cancers, respectively. Antibody-based therapies targeting glypicans are being investigated in preclinical and clinical studies, with the goal of treating solid tumors that do not respond to standard therapies.
TMPK-00060	IL-17B Protein, Mouse, Recombinant (His) IL20,interleukin 17B,interleukin 20,IL-17B,MGC138901,ZCYTO7,...	Mouse	E. coli
	IL-17A, the prototypic member of the IL-17 family, several experimental findings strongly support the role of the IL-17B/IL-17 receptor B (IL-17RB) pathway in tumorigenesis and resistance to anticancer therapies. IL-17B/IL-17RB expression patterns and biological activities in cancer and highlight issues that remain to be addressed to better characterize IL-17B and its receptor as potential targets for enhancing the effectiveness of the existing cancer therapies.
TMPK-01375	PRLR Protein, Canine, Recombinant (hFc) PRL-R,Prolactin R,MFAB,HPRL	Canine	HEK293 Cells
	Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers. PRLR Protein, Canine, Recombinant (hFc) is expressed in HEK293 ...
TMPY-04327	VEGFB Protein, Human, Recombinant (hFc) VRF,血管内皮生长因子,vascular endothelial growth factor B,VEGFL	Human	HEK293 Cells
	Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. In detail, VEGFB can positively prevent the Ang II-induced rising in the size of cardiomyocyte as well as reduce Ang II-induced mRNA and protein levels of β-MHC (β-myosin heavy chain), BNP (brain natriuretic peptide), and ANP (atrial natriuretic peptide). Moreover, VEGFB can regulate the decline of the Ang I...
TMPK-00171	TRAIL Trimer Protein, Human, Recombinant (His & Flag) TRAIL,Apo-2L,APO2L,TL2,Apo-2 ligand,CD253,TNFSF10	Human	HEK293 Cells
	Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing tumor-selective apoptosis leads to the development of TRAIL-based cancer therapies, which include recombinant forms of TRAIL, TRAIL receptor agonists, and other therapeutic agents.
TMPY-03047	Stathmin 1 Protein, Human, Recombinant (His) SMN,OP18,stathmin 1,LAP18,C1orf215,PP17,Lag,PP19,PR22	Human	E. coli
	Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and could be a novel therapeutic target in metastatic GC. STMN1 expression might serve as a biomarker for determining patient atypical meningioma prognosis. Stathmin1 (STMN1) is a cytosolic protein involved in microtubule dynamics through inhibition of tubulin polymerization and prom...
TMPK-00547	PRLR Protein, Cynomolgus, Recombinant (His) Prolactin R,HPRL,MFAB,PRL-R	Cynomolgus	HEK293 Cells
	Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers. PRLR Protein, Cynomolgus, Recombinant (His) is expressed in HEK...
TMPY-06810	SFTPB Protein, Human, Recombinant (His) SFTP3,SMDP1,PSP-B,SFTB3,SP-B	Human	CHO Cells
	Pulmonary surfactant-associated protein B, also known as SFTPB and SP-B, contains one saposin A-type domain and three saposin B-type domains. SP-B is produced primarily by alveolar type II cells (AEC2) but also by nonciliated respiratory epithelial cells lining distal portions of the respiratory tract. Its secretion promotes alveolar homeostasis, stabilizing lipid layers and lowering surface tension at the air-liquid interface in the peripheral air spaces. Alveolar SP-B influences surfactant for...
TMPY-03416	TNFAIP8 Protein, Human, Recombinant (His) GG2-1,tumor necrosis factor, alpha-induced protein 8,SCCS2,S...	Human	E. coli
	Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-alpha inducible anti-apoptotic protein with multiple roles in tumor growth and survival. by the creation of cellular autophagy events, TNFAIP8 promotes cell survival and drug resistance in prostate cancer cells. TNFAIP8 regulates Hippo pathway through interacting with LATS1 to prom...
TMPY-04984	CXCL17 Protein, Human, Recombinant (His) Dcip1,UNQ473,DMC,VCC1,chemokine (C-X-C motif) ligand 17,VCC-...	Human	P. pastoris (Yeast)
	Chemokine (C-X-C motif) ligand 17 (CXCL17) is the latest member of the chemokine family. CXCL17 is a potential oncogene and promising therapeutic target, is an independent biomarker of poor prognosis in patients with breast cancer, and can promote proliferation and migration of breast cancer cells in vitro and in vivo. CXCL17 is expressed in a variety of cancers and promotes tumor progression by recruiting myeloid-derived suppressor cells (MDSCs). CXCL17 attenuates IMQ-induced psoriasis-like ski...
TMPY-06815	SYAP1 Protein, Human, Recombinant (His) PRO3113,synapse associated protein 1	Human	Baculovirus Insect Cells
	Synapse-associated protein 1 (SYAP1), also known as PRO3113 and BSTA, belongs to the synapse-associated BSD domain family, featuring three α-helices and two conserved tryptophan and phenylalanine residues located at the C-terminus. Expressed near neuronal Golgi and synaptic regions of cerebellar Purkinje cells, SYAP1 has been linked to intact sensorimotor control and general vesicular trafficking in neurons. SYAP1-deficient mice display impaired locomotor activity. In cultured adipocytes, SYAP1 ...
TMPY-06821	THRB Protein, Human, Recombinant (His) THRB1,GRTH,THR1,ERBA2,C-ERBA-2,THRB2,thyroid hormone recepto...	Human	E. coli
	Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-binding domain, THRB isoform 1/2 expression localizes predominately to the liver and pituitary, respectively. THRB regulates the feedback of T3-dependent thyrotropin-stimulating hormone (TSH) transcription in the pituitary by binding to thyroid hormone (TH) response elements present...
TMPY-01890	CLIC4 Protein, Human, Recombinant (His) MTCLIC,chloride intracellular channel 4,p64H1,H1,huH1,CLIC4L	Human	E. coli
	Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains oneGST C-terminal domain. CLIC4 is a member of a family of intracellular chloride channels. It is regulated by p53, c-Myc, and tumor necrosis factor-alpha. CLIC4 is detected in epithelial cells from colon, esophagus and kidney (at protein level). CLIC4 has alternate cellular functions like a potential role in angio...

重组蛋白

Hepatitis B Virus (HBV)(ayw/France/Tiollais/1979) Capsid protein (His)

Cat.No: TMPY-05822

Species: HBV-D

Expression System: E. coli

IRAK4 Protein, Human, Recombinant (His)

Cat.No: TMPY-04483

Species: Human

Expression System: Baculovirus Insect Cells

Glypican 2/GPC2 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01081

Species: Mouse

Expression System: HEK293 Cells

IL-17B Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00060

Species: Mouse

Expression System: E. coli

PRLR Protein, Canine, Recombinant (hFc)

Cat.No: TMPK-01375

Species: Canine

Expression System: HEK293 Cells

VEGFB Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04327

Species: Human

Expression System: HEK293 Cells

TRAIL Trimer Protein, Human, Recombinant (His & Flag)

Cat.No: TMPK-00171

Species: Human

Expression System: HEK293 Cells

Stathmin 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03047

Species: Human

Expression System: E. coli

PRLR Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00547

Species: Cynomolgus

Expression System: HEK293 Cells

SFTPB Protein, Human, Recombinant (His)

Cat.No: TMPY-06810

Species: Human

Expression System: CHO Cells

TNFAIP8 Protein, Human, Recombinant (His)

Cat.No: TMPY-03416

Species: Human

Expression System: E. coli

CXCL17 Protein, Human, Recombinant (His)

Cat.No: TMPY-04984

Species: Human

Expression System: P. pastoris (Yeast)

SYAP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-06815

Species: Human

Expression System: Baculovirus Insect Cells

THRB Protein, Human, Recombinant (His)

Cat.No: TMPY-06821

Species: Human

Expression System: E. coli

CLIC4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01890

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T71206	Tiagabine-d6 hydrochloride
	Tiagabine-d6 is intended for use as an internal standard for the quantification of tiagabine by GC- or LC-MS. Tiagabine is an inhibitor of GABA transporter 1. It inhibits seizures induced by DMCM in mice. Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg, and it acts synergistically with gabapentin to delay pain responses in mice in the hot plate test. Formulations containing tiagabine have been used as adjunctive therapies in the treatment of ...
TMIH-0109	Bempedoic acid-d4
	Bempedoic acid-d4 是 Bempedoic acid 的氘代化合物。Bempedoic acid 的 CAS 号为 738606-46-7。ETC-1002 是一种 ATP-柠檬酸裂解酶抑制剂，可激活AMPK。它是脂质和碳水化合物代谢的调节剂。

同位素标记化合物

Tiagabine-d6 hydrochloride

Cat.No: T71206

Bempedoic acid-d4

Cat.No: TMIH-0109

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