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Targets Recommended: Prostaglandin Receptor

119

抑制剂 & 化合物

6

天然产物

5

化合物库

11

重组蛋白

6

同位素标记化合物

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Cat. No.	Product Name
L5400	抗心血管疾病化合物库		1408 compounds
	1408 种心血管疾病相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L4800	血管生成库		1353 compounds
	1353 个高潜力的抑制或促进血管生成的小分子集合，可用于药物靶点开发、血管生成机理研究的高通量筛选，高内涵筛选；
L2600	神经信号分子库		2540 compounds
	2540 种CNS 相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L6140	糖类及苷类化合物库		595 compounds
	595 种糖类或苷类的化合物，可用于高通量筛选和高内涵筛选；
L8500	HIF-1化合物库		1336 compounds
	1336 个HIF-1相关小分子的独特集合，可用于缺血性疾病、癌症等相关领域的药物开发和药理研究；

化合物库

抗心血管疾病化合物库

Cat.No: L5400

Compounds: 1408

血管生成库

Cat.No: L4800

Compounds: 1353

神经信号分子库

Cat.No: L2600

Compounds: 2540

糖类及苷类化合物库

Cat.No: L6140

Compounds: 595

HIF-1化合物库

Cat.No: L8500

Compounds: 1336

Cat. No.	Product Name	Target	Signaling Pathways
T15108	DG-041	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	DG-041 是高亲和力，选择性的，有效的 EP3受体拮抗剂，在结合和 FLIPR 试验中，IC50分别为 4.6 nM 和 8.1 nM。DG-041通过抑制 PGE2促进血小板聚集。DG-041具有血脑屏障渗透性。
T23146	PHA 568487 free base PHA 568487	AChR	Neuroscience
	PHA 568487 free base 是一种选择性的 α7 烟碱乙酰胆碱受体激动剂，可用于减缓神经炎症。
T7946	AER-271	Aquaporin	Membrane transporter/Ion channel
	AER-271 是一种 AER-270 的膦酸酯前药，是aquaporin-4抑制剂，有用于急性缺血性中风的研究潜力。
T39341	FCPR03	PDE	Metabolism
	FCPR03 是一种特异性磷酸二酯酶 4 (PDE4) 抑制剂，对 PDE4B1、PDE4D7 和 PDE4 催化结构域的 IC50 分别为 31 nM、47 nM 和 60 nM。 FCPR03 具有神经保护、抗炎和抗抑郁样作用。
T9820	GPI-1485 GM1485	Others	Others
	GPI-1485 (GM1485) 是一种免疫抑制的特异性亲免蛋白配体，可促进中风后的神经功能改善和神经再生。
T6581	Methyclothiazide Duretic,Enduron,甲氯噻嗪,Aquatensen	Others; Carbonic Anhydrase	Metabolism; Others
	Methyclothiazide (Aquatensen) 是一种具有口服活性的利尿剂，也是一种降压剂。它能够拮抗体外的电压依赖性钙通道的 (VDCC) 活性，也可以抑制内源性血管收缩刺激导致的血管反应。
T3074	CHIR 98024 CHIR98014	GSK-3; S6 Kinase	MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	CHIR 98024是一种有效的 GSK-3α/β 抑制剂，在无细胞试验中 IC50 为 0.65 nM/0.58 nM，能够区分 GSK-3 与其接近的同源物 Cdc2 和 ERK2。
T8887	2'MeO6MF	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	2'MeO6MF 是可透过血脑屏障的α2β1γ2L 和所有含α1的GABAA 受体的正变构调节剂。它也可以直接激活α2β2/3和α2β2/3γ2L GABAA 受体。它具有抗焦虑和促进安定作用。它可提供神经保护作用并改善功能恢复，还可抑制中风诱发的炎症反应。
T21635	PD184161	MEK	MAPK
	PD 184161 是一种口服有效的，时间和浓度依赖的 MEK 抑制剂，IC50为10-100 nM。它诱导抑郁样行为，抑制细胞增殖并诱导细胞凋亡。
T7512	BMS-191011 BMS-A	Potassium Channel	Membrane transporter/Ion channel
	BMS-191011 (BMS-A) 是一种大电导 Ca2+激活的钾通道 (Ca2+-activated potassium (maxi-K) channel) 激活剂，在中风模型中有研究价值。
T8408	GKT136901 AK120765	NADPH-oxidase; NADPH	Immunology/Inflammation; Metabolism
	GKT136901 (AK120765) 是选择性的和具有口服活性的 NADPH 氧化酶 NOX-1/4抑制剂，Ki 分别为 160 和 165 nM。它具有抗炎症活性。它也是一种选择性和直接的过氧亚硝酸清除剂。它可用于糖尿病肾病，中风和神经退行性疾病的研究。
T6504	Flupirtine maleate Katadolon maleate,氟吡啶马来酸,马来酸氟吡汀	Potassium Channel; NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Flupirtine maleate (Katadolon maleate) 是可透过血脑屏障的、具有口服活性的非阿片类化合物。它是间接 NMDAR 拮抗剂，可用于缓解疼痛的研究，具有神经保护特性。
T1057	Azilsartan TAK-536,阿齐沙坦	RAAS	Endocrinology/Hormones
	Azilsartan (TAK-536) 是一种高活性的血管紧张素Ⅱ1型受体特异性拮抗剂(IC50:2.6 nM)。
T0368	Cinepazide maleate 马来酸桂哌齐特,MD-67350,Vasodistal,Brendil	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Cinepazide maleate (MD-67350) 是哌嗪衍生物，是一种钙通道阻滞剂，也是一种强效血管扩张剂，可用于脑血管疾病的研究，如缺血性中风和脑梗塞等。
T2368	Edoxaban Tosylate Monohydrate DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban,依度沙班对甲苯磺酸盐一水化合物	Factor Xa; Thrombin	Metabolism; Proteases/Proteasome
	Edoxaban Tosylate Monohydrate (DU-176b tosylate Monohydrate) 是口服具有活力的 factor Xa 选择性抑制剂。它是一种抗凝剂，可用于预防中风，是一种凝血酶和凝血因子 IXaβ (FIXa) 的弱抑制剂，对 FXa 的选择性超过 10000 倍。它具有抗血栓形成的特性，可用于血栓栓塞性疾病的研究。
T1101	Minocycline hydrochloride Minocycline HCl,盐酸米诺环素,美满霉素	HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic	Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Minocycline hydrochloride (Minocycline HCl) 属于四环素类抗生素，具有出色的吸收和组织渗透性。Minocycline hydrochloride 是一种广谱的抗菌剂，可用于多种细菌感染以及痤疮的治疗。
T6651	Safinamide mesylate PNU-151774E,FCE28073,PNU-151774E,NW-1015,EMD 1195686 mesylate,沙芬酰胺甲磺酸盐	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Safinamide mesylate (EMD 1195686 mesylate) 是选择性的、有效的、可逆的单胺氧化酶 B 的抑制剂，对 MAO-A 选择性较低。它能够阻断钠通道和调节谷氨酸释放。它具有神经保护作用，可用于研究帕金森病、缺血脑卒中等疾病。
T28009	ME-3221 ME 3221,ME3221	RAAS	Endocrinology/Hormones
	ME-3221是一种血管紧张素AT1受体拮抗剂，可预防老年中风易发性高血压大鼠的高血压并发症。
T19659	Annaosanchun 雄甾-3,5,6三醇,YC6,YC-6,YC 6	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	Annaosanchun (YC-6) 有可能用于治疗急性缺血性中风(AIS)。
T77442	Glenzocimab ACT017	Others	Others
	Glenzocimab (ACT017) 是人源化抗 GPVI 单克隆抗体的 Fab 片段。Glenzocimab 在缺血性卒中模型对胶原诱导的血小板聚集显示出抑制作用。Glenzocimab 具有研究急性缺血性脑卒中和脑血栓。
T16286	Nelonemdaz Salfaprodil free base,Neu2000	Antioxidant; NMDAR	Neuroscience; oxidation-reduction
	Nelonemdaz (Neu2000) 是一种 NMDA 受体拮抗剂，具有抗氧化活性和神经保护活性，可用于研究脑梗死再灌注损伤和急性缺血性卒中。
T26645	Aptiganel CNS 1102,CNS-1102,CNS1102	NMDAR	Neuroscience
	Aptiganel (CNS-1102) 是一种非竞争性 NMDA 拮抗剂，是一种多肽，可用于研究急性缺血性卒中。
T27830L	Lifarizine FA Lifarizine FA(119514-66-8 Free base)	Sodium Channel	Membrane transporter/Ion channel
	Lifarizine FA 是一种钠通道阻滞剂，可用于治疗神经系统疾病和心血管疾病，研究脑卒中。
T78141	LFHP-1c	Phosphatase	Metabolism
	LFHP-1c 是一种新型 PGAM5 抑制剂，在缺血性脑卒中模型中显示出神经保护活性，可防止大鼠短暂性大脑中动脉闭塞（tMCAO）后的BBB破坏。LFHP-1c 可用于研究脑缺血性中风。
T14842	BW 245C BW245C	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	BW 245C 是一种选择性的前列腺素类DP受体(DP1)激动剂，是一种前列腺素类似物，对胶原蛋白的聚集反应有抑制作用，可用于研究中风等疾病。
T26389	4-POBN NSC-640,NSC640,4-Aminobenzohydrazide,4-氨基苯甲酰肼,NSC 640,Myeloperoxidase Inhibitor 1,4-ABAH	Glutathione Peroxidase	Metabolism
	4-POBN (Myeloperoxidase Inhibitor 1) 是一种有效且不可逆的髓过氧化物酶抑制剂 (IC50 = 0.3 µM)。 4-POBN 可用于亚急性中风的研究。
T24873	TGX-115 TGX 115	PI3K	PI3K/Akt/mTOR signaling
	TGX-115是一种细胞渗透性和有效的PI 3-K 异构体p110β/p110δ抑制剂(对p110β IC50值为 0.13 μM, 对p110δ值为0.63 μM），是一种调节血小板粘附过程的酶，可抑制磷酸肌苷（PI）3-激酶，可用来治疗冠状动脉闭塞、中风、急性冠状动脉综合征、急性心肌梗塞、血管再狭窄、动脉硬化和不稳定心绞痛等心血管疾病。
T39463	Asundexian BAY 2433334,Asundexian,BAY2433334,BAY-2433334	Factor Xa	Metabolism
	Asundexian (BAY-2433334) 是一种高效且具有口服活性凝血因子 FXIa 抑制剂，可直接且可逆地与FXIa 的活性位点结合，从而抑制其活性。Asundexian 对缓冲液中的人 FXIa 的 IC50 为 1 nM。Asundexian 具有抗肿瘤活性，可用于研究急性缺血性卒中、短暂性脑缺血发作和缺血性卒中。
T7355	IC87201	Others; iGluR	Membrane transporter/Ion channel; Neuroscience; Others
	IC87201 是 PSD95-nNOS 相互作用的抑制剂，可抑制 nMDAR 诱导的一氧化氮和 cGMP 的形成，可用于缺血性中风和疼痛的研究。
T3527	TRC051384 TRC 051384	HSP	Cytoskeletal Signaling; Metabolism
	TRC051384 是一种热休克蛋白70 (HSP70) 诱导剂，可减少中风相关的神经元损伤并增加短暂性缺血性中风大鼠模型的存活率，激活热休克因子-1 并导致分子伴侣和抗炎活性升高，增强神经元和神经胶质细胞中 Hsp72 的表达。
T90611	PF-03049423	Others	Others
	PF-03049423 是一种高效、高选择性的 phosphodiesterase-5A 抑制剂，对大鼠和人血小板酶的 IC50 约为 0.2 nM。PF-03049423 可用于急性缺血性中风的研究。
T16977	Talampanel GYKI-53773,LY-300164	Apoptosis; GluR	Apoptosis; Neuroscience
	Talampanel (LY-300164) 是一种口服和选择型 AMPA 受体拮抗剂，具有抗癫痫活性。在啮齿动物的中风模型中，它具有神经保护作用。Talampanel 减弱 caspase-3 依赖性细胞凋亡。
T3597	Cutamesine dihydrochloride AGY94806 dihydrochloride,库他美新二盐酸盐,SA4503 (dihydrochloride),SA4503 dihydrochloride	Sigma receptor	GPCR/G Protein
	Cutamesine dihydrochloride (SA4503 dihydrochloride) 是一种选择性 σ1 受体激动剂，IC50值为 17.4 nM。
T6295	Dabigatran BIBR 953,BIBR 953ZW,达比加群	Thrombin	Proteases/Proteasome
	Dabigatran (BIBR 953ZW) 是一种口服抗凝剂，是一种可逆的，竞争性的直接凝血酶 (thrombin) 抑制剂，Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。
T22798	Gavestinel GV 150526,Gavestinel sodium salt	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Gavestinel (GV 150526) 是一种非竞争性的 NMDA 受体拮抗剂，具有有效性、选择性和口服活性。Gavestinel 可与 NMDA 受体的甘氨酸位点结合，其结合亲和力(pKi 值)为 8.5。Gavestinel 可用于急性缺血性脑卒中研究。
T22492	2-BFI hydrochloride	Imidazoline Receptor	Neuroscience
	2-BFI hydrochloride 是一种 I2-咪唑啉受体的高亲和力激动剂。 2-BFI hydrochloride 可用于预防中风和急性炎症性免疫疾病的研究。
T21757	BRL 52537 hydrochloride	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	BRL 52537 hydrochloride 是一种选择性和特异性 KOR 激动剂，与缺血性神经元损伤的神经保护有关。它用于研究中风和心脏病发作的潜在治疗方法以及更一般的大脑研究。
T50021	3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid	Others	Others
	3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid （DCPPA）是一种ASIC3抑制剂，可以有效阻断ASIC3介导的疼痛和炎症，已被证明在治疗中风、癫痫和癌症等其他疾病方面具有潜在应用。
T28518	Repinotan HCl X-3702,X 3702,Bayx3702,X3702,Bay-x-3702,Bay x 3702	5-HT Receptor	GPCR/G Protein; Neuroscience
	Repinotan HCl (Bay-x-3702) 是一种可透过血脑屏障且具有口服活性、选择性和高效性的 5-HT1A 受体激动剂，是一种氨甲基苯并联苯胺衍生物。RRepinotan HCl 具有强效的神经保护作用，可用于研究缺血性卒中和创伤性脑损伤。
T66256	Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate	Factor Xa	Metabolism
	Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 对凝血因子Xa具有抑制作用，可用于研究血栓性静脉炎、动脉粥样硬化、脑栓塞、中风、肺栓塞。
T3637	Pifithrin-β hydrobromide Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)	Ferroptosis; p53	Apoptosis
	Pifithrin-β hydrobromide (Cyclic PFT-α) 是一种 p53 的抑制剂，可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。
T28978	Tirilazad mesylate U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate	Antiviral	Immunology/Inflammation
	Tirilazad mesylate (U 74006F) 是一种非糖皮质激素，是一种脂质过氧化抑制剂，具有抗病毒活性和神经保护活性。Tirilazad mesylate 能使细胞膜内病灶局限化，可减轻创伤、中风、缺血再灌注损伤引起的脊髓损伤，抑制狗体内毒素的作用，降低了内毒素诱导的肠系膜和肾脏 DO2 比容升高。Tirilazad mesylate 可用于研究神经系统疾病。
T73447	NP10679	P450; HER; NMDAR; Histamine Receptor	Angiogenesis; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	NP10679 是一种可口服且具有选择性、脑穿透性、高效性和 pH 敏感性的 GluN2B 亚基的 N-methyl-D-aspartate (NMDA) 受体抑制剂。NP10679 抑制 histamine H1 、 hERG 通道和 CYP 酶，可用于研究癫痫和缺血性卒中。
TP1937L1	RFRP-1 (human) acetate(311309-25-8 free base)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	RFRP-1 (human) acetate(311309-25-8 free base) 是一种有效的内源性 NPFF 受体激动剂（NPFF2 和 NPFF1 的 EC50 值分别为 0.0011 和 29 nM）。它减弱离体大鼠和兔心肌细胞的收缩功能。降低心率、每搏输出量、射血分数和心输出量，并增加大鼠的血浆催乳素水平。 GnIH 同系物。
T13112	Tat-NR2B9c Tat-NR2Bct,NA-1	NO Synthase; iGluR	Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Tat-NR2B9c (NA-1) 是一种突触后密度-95（PSD-95）抑制剂，具有神经保护和抗癫痫作用。Tat-NR2B9c 可抑制PSD-95d2、 PSD-95d1 和 PSD-95，可阻止NMDA诱导的神经元NADPH氧化酶的激活，从而阻断超氧化物的产生，可减少中风后急性期的缺血性损伤。
T61934	Repinotan BAY x 3702 free base	5-HT Receptor	GPCR/G Protein; Neuroscience
	Repinotan (BAY x 3702 free base) 是一种可透过血脑屏障（BBB)且具有口服活性和选择的 5-HT1A 受体激动剂，具有神经保护活性，可拮抗吗啡诱导的麻醉大鼠通气抑制，可用于研究急性缺血性中风和创伤性脑损伤。
T1613	Hydralazine hydrochloride Hydralazine HCl,Apresoline,盐酸肼屈嗪	MAO; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Neuroscience
	Hydralazine hydrochloride (Apresoline) 是一种直接作用的血管舒张剂，可抗高血压。
T3560	Desmethylanethol trithione ADT-OH	VEGFR; Akt	Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Desmethylanethol trithione (ADT-OH) 是合成硫化氢的供体。它利用上调 FADD 诱导细胞凋亡，并对体内黑色素瘤的形成具有一定的抑制作用，可用于研究癌症疾病。
T31206	Darexaban YM 150,Darexaban, Tanexaban,YM150	Factor Xa	Metabolism
	Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂，IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。
T1551	Tegaserod maleate HTF-919,马来酸替加色罗,SDZ-HTF-919	5-HT Receptor	GPCR/G Protein; Neuroscience
	Tegaserod maleate (SDZ-HTF-919) 是选择性5-HT4受体的部分激动剂和5-HT2B 受体的拮抗剂，用于治疗肠易激综合征和便秘。

化合物

Cat.No: T15108

Target: Prostaglandin Receptor

PHA 568487 free base

Cat.No: T23146

Synonym: PHA 568487

Target: AChR

Cat.No: T7946

Target: Aquaporin

Cat.No: T39341

Target: PDE

Cat.No: T9820

Synonym: GM1485

Target: Others

Methyclothiazide

Cat.No: T6581

Synonym: Duretic,Enduron,甲氯噻嗪,Aquatensen

Target: Others, Carbonic Anhydrase

Cat.No: T3074

Synonym: CHIR98014

Target: GSK-3, S6 Kinase

Cat.No: T8887

Target: GABA Receptor

Cat.No: T21635

Target: MEK

Cat.No: T7512

Synonym: BMS-A

Target: Potassium Channel

Cat.No: T8408

Synonym: AK120765

Target: NADPH-oxidase, NADPH

Flupirtine maleate

Cat.No: T6504

Synonym: Katadolon maleate,氟吡啶马来酸,马来酸氟吡汀

Target: Potassium Channel, NMDAR, iGluR

Cat.No: T1057

Synonym: TAK-536,阿齐沙坦

Target: RAAS

Cinepazide maleate

Cat.No: T0368

Synonym: 马来酸桂哌齐特,MD-67350,Vasodistal,Brendil

Target: Calcium Channel

Edoxaban Tosylate Monohydrate

Cat.No: T2368

Synonym: DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban,依度沙班对甲苯磺酸盐一水化合物

Target: Factor Xa, Thrombin

Minocycline hydrochloride

Cat.No: T1101

Synonym: Minocycline HCl,盐酸米诺环素,美满霉素

Target: HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

Safinamide mesylate

Cat.No: T6651

Synonym: PNU-151774E,FCE28073,PNU-151774E,NW-1015,EMD 1195686 mesylate,沙芬酰胺甲磺酸盐

Target: MAO, Monoamine Oxidase

Cat.No: T28009

Synonym: ME 3221,ME3221

Target: RAAS

Cat.No: T19659

Synonym: 雄甾-3,5,6三醇,YC6,YC-6,YC 6

Target: Others, AMPK

Cat.No: T77442

Synonym: ACT017

Target: Others

Cat.No: T16286

Synonym: Salfaprodil free base,Neu2000

Target: Antioxidant, NMDAR

Cat.No: T26645

Synonym: CNS 1102,CNS-1102,CNS1102

Target: NMDAR

Cat.No: T27830L

Synonym: Lifarizine FA(119514-66-8 Free base)

Target: Sodium Channel

Cat.No: T78141

Target: Phosphatase

Cat.No: T14842

Synonym: BW245C

Target: Prostaglandin Receptor

Cat.No: T26389

Synonym: NSC-640,NSC640,4-Aminobenzohydrazide,4-氨基苯甲酰肼,NSC 640,Myeloperoxidase Inhibitor 1,4-ABAH

Target: Glutathione Peroxidase

Cat.No: T24873

Synonym: TGX 115

Target: PI3K

Cat.No: T39463

Synonym: BAY 2433334,Asundexian,BAY2433334,BAY-2433334

Target: Factor Xa

Cat.No: T7355

Target: Others, iGluR

Cat.No: T3527

Synonym: TRC 051384

Target: HSP

Cat.No: T90611

Target: Others

Cat.No: T16977

Synonym: GYKI-53773,LY-300164

Target: Apoptosis, GluR

Cutamesine dihydrochloride

Cat.No: T3597

Synonym: AGY94806 dihydrochloride,库他美新二盐酸盐,SA4503 (dihydrochloride),SA4503 dihydrochloride

Target: Sigma receptor

Cat.No: T6295

Synonym: BIBR 953,BIBR 953ZW,达比加群

Target: Thrombin

Cat.No: T22798

Synonym: GV 150526,Gavestinel sodium salt

Target: NMDAR, iGluR

2-BFI hydrochloride

Cat.No: T22492

Target: Imidazoline Receptor

BRL 52537 hydrochloride

Cat.No: T21757

Target: Opioid Receptor

3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid

Cat.No: T50021

Target: Others

Cat.No: T28518

Synonym: X-3702,X 3702,Bayx3702,X3702,Bay-x-3702,Bay x 3702

Target: 5-HT Receptor

Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

Cat.No: T66256

Target: Factor Xa

Pifithrin-β hydrobromide

Cat.No: T3637

Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)

Target: Ferroptosis, p53

Tirilazad mesylate

Cat.No: T28978

Synonym: U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate

Target: Antiviral

Cat.No: T73447

Target: P450, HER, NMDAR, Histamine Receptor

RFRP-1 (human) acetate(311309-25-8 free base)

Cat.No: TP1937L1

Target: Neuropeptide Y Receptor

Cat.No: T13112

Synonym: Tat-NR2Bct,NA-1

Target: NO Synthase, iGluR

Cat.No: T61934

Synonym: BAY x 3702 free base

Target: 5-HT Receptor

Hydralazine hydrochloride

Cat.No: T1613

Synonym: Hydralazine HCl,Apresoline,盐酸肼屈嗪

Target: MAO, HIF/HIF Prolyl-Hydroxylase

Desmethylanethol trithione

Cat.No: T3560

Synonym: ADT-OH

Target: VEGFR, Akt

Cat.No: T31206

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

Tegaserod maleate

Cat.No: T1551

Synonym: HTF-919,马来酸替加色罗,SDZ-HTF-919

Target: 5-HT Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T3871	Daucosterol Alexandrin,Sitogluside,β-Sitosterol β-D-glucoside,Eleutheroside A,西托糖苷	Glucosidase	Metabolism
	Daucosterol (Sitogluside) 是天然的甾醇体类化合物。
T4917	Dehydroascorbic acid (L)-Dehydroascorbic acid,脱氢抗坏血酸,去氢抗坏血酸	Endogenous Metabolite	Metabolism
	Dehydroascorbic acid ((L)-Dehydroascorbic acid) 是维生素 C 的氧化型，能够透过血脑屏障，对中风具有有效的脑保护作用。
T4439	sn-Glycero-3-phosphocholine Choline Alfoscerate,甘磷酸胆碱,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC	Endogenous Metabolite; AChE	Metabolism; Neuroscience
	sn-Glycero-3-phosphocholine (Choline glycerophosphate) 是脑磷脂生物合成的前体，能够提高胆碱在神经组织中的生物利用度。它对认知功能有显著影响，同时具有良好的耐受性和安全性，因此能够用于阿尔茨海默病和痴呆症的研究。
T5S1632	Barlerin 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01	VEGFR; TNF; NF-κB; Akt; Caspase	Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷，从中国西藏民间药用植物中分离得到，能够抑制NF-κB 活性。
TN3323	Monomethyl lithospermate Lithospermic acid monomethyl ester	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Monomethyl lithospermate (Lithospermic acid monomethyl ester) 具有潜在的抗病毒活性，通过激活PI5K/Akt信号传导，减轻体内大脑中动脉闭塞小鼠缺血性中风损伤，并在体外保护氧葡萄糖剥夺/复氧诱导的SHSY-3Y细胞。Monomethyl lithospermate 能提高 SHSY-5Y 细胞的生存能力，抑制线粒体膜电位 (MMOP) 崩溃，抑制细胞凋亡。Monomethyl lithospermate 还降低中动脉闭塞 (MCAO) 大鼠脑组织中的氧化应激水平，改善缺血性中风 (IS) 大鼠神经损伤。
TN2257	Tanshinone IIB 丹参酮ⅡB	BCL; Caspase; P-gp	Apoptosis; Membrane transporter/Ion channel; Neuroscience; Proteases/Proteasome
	Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the elevated Bax protein and decreased bc

天然产物

Cat.No: T3871

Synonym: Alexandrin,Sitogluside,β-Sitosterol β-D-glucoside,Eleutheroside A,西托糖苷

Target: Glucosidase

Dehydroascorbic acid

Cat.No: T4917

Synonym: (L)-Dehydroascorbic acid,脱氢抗坏血酸,去氢抗坏血酸

Target: Endogenous Metabolite

sn-Glycero-3-phosphocholine

Cat.No: T4439

Synonym: Choline Alfoscerate,甘磷酸胆碱,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC

Target: Endogenous Metabolite, AChE

Cat.No: T5S1632

Synonym: 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

Monomethyl lithospermate

Cat.No: TN3323

Synonym: Lithospermic acid monomethyl ester

Target: Akt, PI3K

Cat.No: TN2257

Synonym: 丹参酮ⅡB

Target: BCL, Caspase, P-gp

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01075	Von Willebrand Factor/vWF Protein, Human, Recombinant (His) von Willebrand factor,VWD,F8VWF	Human	CHO Cells
	Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thr...
TMPY-00344	ARL6IP6 Protein, Human, Recombinant (mFc) PFAAP1,AIP-6,ADP-ribosylation factor-like 6 interacting prot...	Human	HEK293 Cells
	It had been found that a homozygous truncating mutation in ARL6IP6 as the likely cause of a syndromic form of CMTC associated with major dysmorphism, developmental delay, transient ischemic attacks and cerebral vascular malformations. This gene was previously implicated by genome wide association study (GWAS) as a susceptibility locus to ischemic stroke in young adults. We identify ARL6IP6 as a novel candidate gene for a syndromic form of CMTC. This suggests that ischemic stroke or transient isc...
TMPY-00410	EPHX2 Protein, Human, Recombinant (His) SEH,CEH,epoxide hydrolase 2, cytoplasmic	Human	Baculovirus Insect Cells
	Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the human EPHX2 gene had been implicated in susceptibility to cardiovascular disease, including stroke. The human EPHX2 mutations may in part explain the genetic variability in sensitivity to ischemic brain injury and stroke outcome. Epoxide hydrolase is involved in metabolism of vas...
TMPJ-01022	SUMO3 Protein, Human, Recombinant (HEK293, His) SMT3 homolog 1,Smt3A,Small ubiquitin-related modifier 3,Ubiq...	Human	HEK293 Cells
	Small ubiquitin-like modifier (SUMO), also known as SUMO homologue and SMT3, is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various intracellular target proteins as a way to alter their function, location, and/or half-life. Small ubiquitin-like modifiers include SUMO1, SUMO2, SUMO3, and SUMO4. Except for SUMO4, all other SUMOs are ubiquitously expressed, including in the brain. In human, SUMO2 and SUMO3 are two highly homologous proteins, collect...
TMPY-01481	FLAP Protein, Human, Recombinant (His) FLAP,arachidonate 5-lipoxygenase-activating protein	Human	Baculovirus Insect Cells
	Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP), also known as FLAP, belongs to the MAPEG family. ALOX5AP/FLAP is an essential partner of 5-LO for this process. The FLAP (ALOX5AP) gene has been linked to risk for myocardial infarction, stroke and restenosis, reigniting pharmaceutical interest in this target. It had been found that ALOX5AP/FLAP is a key enzyme in leukotriene formation, in both human pulmonary microvascular endothelial cells and a transformed human brain endothelial cell ...
TMPY-02298	ACYP2 Protein, Human, Recombinant (GST) ACYM,acylphosphatase 2, muscle type,ACYP	Human	E. coli
	Recent genome-wide association studies have identified genetic variants in ACYP2 and WFS1 that are associated with cisplatin-induced ototoxicity. We sought to explore the role of these genetic susceptibility factors to cisplatin-induced ototoxicity in patients with testicular cancer. Telomere length, as a marker of biological aging, has been reported to influence the risk of several age-related diseases, including ischemic stroke. Recent studies have identified the genetic variant within ACYP2 a...
TMPJ-00857	Thrombomodulin Protein, Mouse, Recombinant (His) Fetomodulin,Thbd,BDCA-3,Thrombomodulin,CD141,TM	Mouse	HEK293 Cells
	Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Mouse THBD is corresponding to the extracellular portion of the type I membrane protein. Predominantly synthesized by vascular endothelial cells, THBD inhibits ...
TMPY-02376	BNIP3L Protein, Human, Recombinant BCL2/adenovirus E1B 19kDa interacting protein 3-like,NIX,BNI...	Human	E. coli
	The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to the endoplasmic reticulum and Golgi apparatus of wild-type newborn mouse lenses and is contained within mitochondria, endoplasmic reticulum and Golgi apparatus isolated from adult mouse liver. As the cells become packed with keratin bundles, Bnip3L expression triggers mitophagy to...
TMPY-01303	Serpin A3 Protein, Human, Recombinant (His) ACT,GIG25,serpin peptidase inhibitor, clade A (alpha-1 antip...	Human	HEK293 Cells
	SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has been demonstrated to inhibit the activity of certain serine proteases, such as cathepsin G found in neutrophils, and chymases present in mast cells, by inducing a major conformational rearrangement, and thus protects some tissues from damage caused by proteolytic enzymes. This enzy...
TMPY-02043	PARK7/DJ-1 Protein, Human, Recombinant (His) DJ1,HEL-S-67p,DJ-1,parkinson protein 7	Human	E. coli
	Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress...
TMPY-04467	NME1 Protein, Human, Recombinant (His) NME/NM23 nucleoside diphosphate kinase 1,NB,NDPK-A,NM23-H1,N...	Human	E. coli
	NME1, also known as Nucleoside Diphosphate Kinase A (NDK-A), or NM23-H1, belongs to the NDK family. NM23-H1 is known to have a metastasis suppressive activity in many tumor cells. Recent studies have shown that the interacting proteins with NM23-H1 which mediate cell proliferation, may act as modulators of the metastasis suppressor activity. The interacting proteins with NM23-H1 can be classified into 3 groups. The first group of proteins can be classified as upstream kinases of NM23-H1 such as ...

重组蛋白

Von Willebrand Factor/vWF Protein, Human, Recombinant (His)

Cat.No: TMPY-01075

Species: Human

Expression System: CHO Cells

ARL6IP6 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00344

Species: Human

Expression System: HEK293 Cells

EPHX2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00410

Species: Human

Expression System: Baculovirus Insect Cells

SUMO3 Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPJ-01022

Species: Human

Expression System: HEK293 Cells

FLAP Protein, Human, Recombinant (His)

Cat.No: TMPY-01481

Species: Human

Expression System: Baculovirus Insect Cells

ACYP2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02298

Species: Human

Expression System: E. coli

Thrombomodulin Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00857

Species: Mouse

Expression System: HEK293 Cells

BNIP3L Protein, Human, Recombinant

Cat.No: TMPY-02376

Species: Human

Expression System: E. coli

Serpin A3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01303

Species: Human

Expression System: HEK293 Cells

PARK7/DJ-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02043

Species: Human

Expression System: E. coli

NME1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04467

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0070	Androstane-3,5,6-triol-d4
	Androstane-3,5,6-triol-d4 是 Androstane 的氘代化合物。Androstane 的 CAS 号为 4725-51-3。Annaosanchun 有可能用于治疗急性缺血性中风（AIS）。
TMIJ-0132	Edoxaban-d6
	Edoxaban-d6 是 Edoxaban 的氘代化合物。Edoxaban 的 CAS 号为 480449-70-5。Edoxaban 是一种口服 Xa 因子 (FXa) 抑制剂，用于中风预防的临床开发。
TMIH-0173	Dabigatran-d4 HCl
	Dabigatran-d4 HCl 是 Dabigatran HCl 的氘代化合物。Dabigatran HCl 的 CAS 号为 211914-51-1。Dabigatran 是一种口服抗凝剂，是一种可逆的，竞争性的直接凝血酶 (thrombin) 抑制剂，Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。
TMIJ-0003	Dabigatran-13C-d3
	Dabigatran-13C-d3 是 Dabigatran 的 13C 和氘代化合物。Dabigatran 的 CAS 号为 211914-51-1。Dabigatran 是一种口服抗凝剂，是一种可逆的，竞争性的直接凝血酶 (thrombin) 抑制剂，Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。
TMIJ-0002	Dabigatran-13C6
	Dabigatran-13C6 是 Dabigatran 的 13C 的标记化合物。Dabigatran 的 CAS 号为 211914-51-1。Dabigatran 是一种口服抗凝剂，是一种可逆的，竞争性的直接凝血酶 (thrombin) 抑制剂，Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。
TMID-0040	Palmitoyl L-Carnitine-d3 Hydrochloride
	Palmitoyl L-Carnitine-d3 Hydrochloride 是 Palmitoyl L-Carnitine Hydrochloride 的氘代化合物。Palmitoyl L-Carnitine Hydrochloride 的 CAS 号为 18877-64-0。L-Palmitoylcarnitine chloride (Palmitoyl-L-carnitine chloride)是一种脂肪酸代谢产物，具有抗血栓形成的作用，通过抵消tMCAO模型中的脑内血栓形成来保护小鼠免受缺血性中风。L-Palmitoylcarnitine chloride抑制心脏中的Na/K泵，抑制 FeCl 3诱导的动脉血栓形成，减轻了短暂性大脑中动脉闭塞（tMCAO）小鼠模型的脑内血栓形成和炎症。

同位素标记化合物

Androstane-3,5,6-triol-d4

Cat.No: TMIJ-0070

Cat.No: TMIJ-0132

Dabigatran-d4 HCl

Cat.No: TMIH-0173

Dabigatran-13C-d3

Cat.No: TMIJ-0003

Dabigatran-13C6

Cat.No: TMIJ-0002

Palmitoyl L-Carnitine-d3 Hydrochloride

Cat.No: TMID-0040

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