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Search Results for " neurological "

Targets Recommended: Src

323

抑制剂 & 化合物

22

天然产物

11

化合物库

15

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name
L7400	钠通道分子库		118 compounds
	118 种钠通道相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L2800	5-羟色胺分子库		268 compounds
	268 种生物活性小分子化合物，用于高通量、高内涵筛选；
L2600	神经信号分子库		2540 compounds
	2540 种CNS 相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L4660	神经疾病库Plus		1246 compounds
	1246 种神经系统相关、结构新颖的化合物；
L1610	FDA 上市激酶抑制剂库		263 compounds
	263种靶向激酶的上市药物集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；
L7700	神经再生化合物库		524 compounds
	524 种神经再生相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L3300	组胺&褪黑色素化合物库		153 compounds
	153 种生物活性小分子化合物，用于高通量、高内涵筛选；
L2610	神经递质受体化合物库		1513 compounds
	1513 种与神经递质受体相关的化合物，用于高通量、高内涵筛选；
L8720	细胞焦亡化合物库		1066 compounds
	1066 种细胞焦亡相关的化合物，可以用于细胞焦亡相关研究。
L2630	神经元分化化合物库		672 compounds
	672 种与神经元分化相关的化合物，可以用于神经系统疾病药物研发
L9840	抗阿尔茨海默症化合物库		986 compounds
	986 种阿尔茨海默症相关的化合物集合，可用于高通量和高内涵筛选；

化合物库

钠通道分子库

Cat.No: L7400

Compounds: 118

5-羟色胺分子库

Cat.No: L2800

Compounds: 268

神经信号分子库

Cat.No: L2600

Compounds: 2540

神经疾病库Plus

Cat.No: L4660

Compounds: 1246

FDA 上市激酶抑制剂库

Cat.No: L1610

Compounds: 263

神经再生化合物库

Cat.No: L7700

Compounds: 524

组胺&褪黑色素化合物库

Cat.No: L3300

Compounds: 153

神经递质受体化合物库

Cat.No: L2610

Compounds: 1513

细胞焦亡化合物库

Cat.No: L8720

Compounds: 1066

神经元分化化合物库

Cat.No: L2630

Compounds: 672

抗阿尔茨海默症化合物库

Cat.No: L9840

Compounds: 986

Cat. No.	Product Name	Target	Signaling Pathways
T9723	GluR6 antagonist-1	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	GluR6 antagonist-1 抑制酪氨酸激酶 p56lck SH2 结构域的 pY 结合位点。
T23116	Oxotremorine sesquifumarate	AChR	Neuroscience
	Oxotremorine sesquifumarate 是一种毒蕈碱受体激动剂，对 M2 的激活作用更强，可用于神经学研究。
T9989	AChE-IN-27	Others	Others
	AChE-IN-27是一种用于高通量测定的小分子。
T15052	Dapansutrile	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	Dapansutrile 是一种口服有活性的 NLRP3 炎性小体选择性抑制剂。它具有抗炎特性，可用于研究缓解疼痛。
T35878	N-(3-Aminopropyl)cyclohexylamine	Others	Others
	N-(3-Aminopropyl)cyclohexylamine, a derivative of cyclohexylamine, functions as a selective and competitive inhibitor of spermine synthase, making it suitable for research on neurological diseases[1].
TP1856	Colivelin	Beta Amyloid; STAT	JAK/STAT signaling; Neuroscience; Stem Cells
	Colivelin 是一种神经保护肽和 STAT3 的激活剂，是一种合成的杂合肽，可增强 humanin (HN) 的神经保护作用。它通过激活 STAT3 在体外抑制神经元死亡，具有潜力用于阿尔茨海默病和缺血性脑损伤的相关研究。
T13320L	VU591	Potassium Channel	Membrane transporter/Ion channel
	VU591 是选择性的肾外髓钾通道抑制剂，IC50为 0.24 μM。
T4330	CaCCinh-A01	Chloride channel	Membrane transporter/Ion channel
	CaCCinh-A01 是钙激活氯离子通道和TMEM16A 抑制剂，IC50值分别为 10 和 2.1 μM。
T12421	PF-04885614	Sodium Channel	Membrane transporter/Ion channel
	PF-04885614是一种有效的NaV1.8抑制剂。PF-04885614有用于神经系统疾病和神经发育疾病研究的潜力。
TQ0046	Bavisant JNJ-31001074	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bavisant (JNJ-31001074) 是一种特异性和口服活性的人 H3 受体拮抗剂。 Bavisant 可用于作用机制的研究，包括觉醒和认知以及 ADHD 的治疗。
T0776	Phenothiazine ENT 38,吩噻嗪	Dopamine Receptor; Antibacterial; Antibiotic; Antifungal	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Phenothiazine (ENT 38) 是一种抗生素，具有杀虫，抗菌，驱虫和杀真菌活性。它也可研究神经系统疾病。
T9694	Emraclidine CVL-231	AChR	Neuroscience
	Emraclidine (CVL-231) 是一种毒蕈碱 M4 受体阳性变构调节剂，可用于神经系统疾病研究。
T9149	2BAct 2B-Act,2B Act	PERK	Apoptosis
	2BAct 是一种具有口服活性的高选择性真核起始因子eIF2B 活化剂，EC50为 33 nM。它可防止由慢性综合应激反应引起的神经系统缺陷。
T13320	VU591 hydrochloride	Potassium Channel	Membrane transporter/Ion channel
	VU591 hydrochloride 是选择性的肾外髓钾通道抑制剂，IC50为 0.24 μM。
T8944	TTA-A2	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	TTA-A2 是一种选择性 T 型钙通道拮抗剂，是一种有效的抗惊厥药，可减少孕烷 X 受体的激活。它对 Cav3.1 (a1G) 和 Cav3.2 (a1H) 通道在 -80 mV 和- 100 mV 保持电位上具有同样的作用，IC50 值分别为 89 和 92 nM。它可用于多种人类神经系统疾病的研究，包括睡眠障碍和癫痫。
T4497	Amifampridine 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine	Others	Others
	Amifampridine (3,4-Diaminopyridine) 可用于罕见肌肉疾病的研究。
T1594	Vecuronium bromide ORG NC 45,维库溴铵	AChR	Neuroscience
	Vecuronium bromide (ORG NC 45) 是一种合成的中效单季铵盐类固醇和非去极化神经肌肉阻滞剂，具有肌肉松弛活性。
T0082	Domperidone R33812,多潘立酮	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Domperidone (R33812) 是多巴胺 2 受体拮抗剂，能够影响胃和小肠的化学感受器触发区和运动功能，具有止吐和促动力作用。
T8930	CID44216842 KUC103479N-02	CDK; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CID44216842 (KUC103479N-02) 是Cdc42选择性抑制剂。在 GDP 结合测定中，它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 0.3 和 0.5 μM。在 GTP 结合测定中，它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 1.0 和 1.2 μM。它可用作分子探针。
T1476	Pramipexole SND 919,普拉克索	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Pramipexole (SND 919) 是能够透过血脑屏障的 D2 型多巴胺受体的选择性激动剂，对 D2 型受体、D2、D3、D4亚型受体的Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM。它可用于研究帕金森综合症和腿多动综合征。
T4074	GSK-872 GSK872,GSK'872,GSK2399872A	RIP kinase	Apoptosis; NF-κB
	GSK-872 (GSK2399872A) 是一种有效且特异性的 RIP3 激酶抑制剂，降低 RIPK3 介导的坏死和随后的 HMGB1 的细胞质易位和表达，可改善早期脑损伤中的脑水肿和神经功能缺损。它以高亲和力结合 RIP3 激酶结构域，IC50为1.8 nM，并抑制激酶活性，IC50为1.3 nM。
T3198L	PRE-084 hydrochloride	Sigma receptor	GPCR/G Protein
	PRE-084 hydrochloride 是 σ1 的选择性激动剂在sigma 受体检测中，IC50值为44 nM。
T6950	PNU-120596 NSC 216666	AChR	Neuroscience
	PNU-120596 (NSC-216666) 是一种选择性α7 nAChR 阳性变构调节剂，EC50为 216 nM，可用于精神病和神经疾病的研究。
T12256	NS8593 hydrochloride NS8593 HCl	Potassium Channel	Membrane transporter/Ion channel
	NS8593 hydrochloride (NS8593 HCl) 是选择性的 SK 通道抑制剂。它可逆抑制 SK3介导的电流，Kd 值为 77 nM。它抑制所有 SK1-3亚型的 Ca2+依赖性 (在 0.5 μM Ca2+时，Kd 分别为 0.42、0.60 和 0.73 μM)，并且不影响中间电导和大电导的钙激活钾通道。
T7805	GW791343 dihydrochloride GW791343 (HCl)	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	GW791343 dihydrochloride (GW791343 (HCl)) 是有种属特异性的 P2X7变构调节剂，对人 P2X7的 pIC50为6.9-7.2。
T3217	PF-CBP1 hydrochloride PF-CBP1 HCl	Epigenetic Reader Domain; Histone Acetyltransferase	Chromatin/Epigenetic
	PF-CBP1 hydrochloride (PF-CBP1 HCl) 是 CREB 结合蛋白溴结构域的一种高选择性抑制剂，抑制 CREBBP 和 EP300溴结构域的 IC50分别为 125 和 363 nM。它降低 LPS 诱导的巨噬细胞中炎症因子的表达，也可下调皮质神经元 RGS4 的表达，可用于癫痫和帕金森病等神经疾病的研究。
T6951	Pramipexole dihydrochloride hydrate Pramipexole 2HCl Monohydrate,普拉克索盐酸盐水合物,Mirapex,普拉克索	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Pramipexole dihydrochloride hydrate (Mirapex) 是选择性的，具有血脑屏障 (BBB) 渗透性的 D2 型多巴胺受体激动剂，对 D2 型受体、D2、D3、D4亚型受体的 Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM，可用于研究帕金森综合症和腿多动综合征。
T15247	ESI-05 NSC 116966	cAMP	GPCR/G Protein
	ESI-05 (NSC-116966) 是特异性的 cAMP 直接激活交换蛋白 2 (EPAC2) 拮抗剂(IC50:0.4 µM)，能够抑制 cAMP 诱导的 EPAC2 的活化，并 EAPC2 介导的 Rap1 的活化。
T4369	SCH-23390 hydrochloride R-(+)-SCH23390 hydrochloride	Potassium Channel; Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) 是一种选择性多巴胺 D1样受体拮抗剂，对 D1和 D5受体的Ki 分别为 0.2 和 0.3 nM。它还抑制 G 蛋白偶联的内向整流钾通道，IC50为 268 nM。它与5-HT2和5-HT1C 受体具有高亲和力，是人5-HT2C 受体激动剂，Ki 为 9.3 nM。
T15684	L-689560	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	L-689560 是 N-甲基-D-天冬氨酸受体（NMDA）的有效拮抗剂，抑制 NMDA 甘氨酸结合位点。它用于研究 NMDA 受体在正常神经系统过程以及疾病中的作用，也广泛用作结合研究中的放射性标记配体，也。
T6526	GW791343 trihydrochloride GW791343 3HCl	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	GW791343 trihydrochloride (GW791343 3HCl) 是 P2X7变构调节剂，有种属特异性，对人 P2X7的pIC50为6.9-7.2。
T12865	SCH-23390 maleate R-(+)-SCH-23390 maleate	Potassium Channel; Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	SCH-23390 maleate (R-(+)-SCH-23390 maleate) 是多巴胺D1样受体选择性拮抗剂，与D1和D5受体结合的Ki 分别为 0.2 nM 和 0.3 nM。它也是人5-HT2C 受体激动剂，Ki 为 9.3 nM。它与5-HT2和5-HT1C 受体具有高亲和力。它还抑制 G 蛋白偶联的内向整流钾通道，IC50为 268 nM。
T68063	Elopiprazole DU 29840	Others	Others
	Elopiprazole(DU 29840) 是一种抗神经病化合物，可用来研究神经系统疾病。
T84365	Clozapine Analogues	Others	Others
	Clozapine Analogues 可用于研究神经系统疾病。
T26890	BP14979 BP-14979,BP1,4979,BP-1,4979,BP 1,4979,BP 14979	Dopamine Receptor	GPCR/G Protein; Neuroscience
	BP14979 是多巴胺D3受体激动剂，可用于研究神经系统疾病。
T28258	Org-13011 fumarate Org13011,Org 13011	5-HT Receptor	GPCR/G Protein; Neuroscience
	Org-13011 fumarate1 是 5-HT1A 受体的激动剂，可用于研究神经系统疾病。
T27838	Lirequinil RO413696,RO-413696,RO41-3696,RO 413696,Ro 41-3696,Ro-41-3696	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Lirequinil (Ro 41-3696) 是一种小分子 GABAA 受体激动剂，可用于研究神经系统疾病。
T11424	Glutaminyl Cyclase Inhibitor 1	Guanylate cyclase	GPCR/G Protein
	Glutaminyl Cyclase Inhibitor 1 是一种谷氨酰胺环化酶抑制剂（IC50：0.5 μM），可用于研究神经系统疾病。
T15553	Iganidipine NKY 722	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Iganidipine（NKY 722）是一种新的水溶性 Ca2+ 拮抗剂，具有降压活性，可用于研究和神经系统相关的疾病。
T30998L	COG-1410 acetate COG-1410 acetate(878009-24-6 Free base)	Apoptosis	Apoptosis
	COG-1410 acetate 是一种载脂蛋白 E 衍生肽，可用于神经系统疾病的研究。
T15456	GYKI 53655 hydrochloride GYKI53655 hydrochloride,LY300168 hydrochloride	GluR	Neuroscience
	GYKI 53655 hydrochloride (LY300168 hydrochloride) 是一种 AMPA 的拮抗剂，可用于研究神经系统疾病。
T13963	W-2429 NSC294836	Others	Others
	W-2429 (NSC294836) 是一种非麻醉性镇痛剂，可用用于研究神经系统疾病。
T15655	KFM19	Adenosine Receptor	GPCR/G Protein; Neuroscience
	KFM19 是一种具有强效性和选择性的腺苷受体 (A1-receptor) 拮抗剂(IC50 ： 50 nM)，可用于研究神经系统疾病。
T14974	Citenamide Cytenamide,AY-15613	Others	Others
	Citenamide (AY-15613) 具有抗癌和抗惊厥活性，具有促进睡眠的作用，可用于研究神经系统疾病。
T27143	Delucemine Hydrochloride NPS 1506,Delucemine,Delucemine HCl,NPS1506,NPS-1506	NMDAR	Neuroscience
	Delucemine Hydrochloride (Delucemine) 是一种多胺NMDA受体拮抗剂，可用于研究抑郁症和阿尔茨海默症等神经系统疾病。
T22736	DMeOB 3,3'-Dimethoxybenzaldazine	GluR	Neuroscience
	DMeOB (3,3'-Dimethoxybenzaldazine) 是具有mGluR5 激动剂活性的负调节剂，可用于研究神经系统疾病。
T24840	STS-E412 STS E412,STSE412	Others	Others
	STS-E412 是一种具有组织保护性和选择性的 EPOR/CD131 受体激活剂，可用于研究神经系统疾病。
T22850	ICI 204,448 ICI 204448,ICI204448,ICI-204448	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	ICI 204,448 是一种有效的 κ-阿片类激动剂，具有潜在的镇痛活性，可用于研究神经系统疾病。
T26119	Romifidine Romifidinum	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Romifidine (Romifidinum) 是 α2 肾上腺素受体激动剂，具有镇痛和抗伤害作用，可用于研究神经系统疾病。
T31354	Decimemide V 285,V-285,V285	Others	Others
	Decimemide (V-285)是一种烷氧基苯甲酸衍生物，具有抗癫痫活性和潜在的抗惊厥活性，可用研究神经系统疾病。

化合物

GluR6 antagonist-1

Cat.No: T9723

Target: Src

Oxotremorine sesquifumarate

Cat.No: T23116

Target: AChR

Cat.No: T9989

Target: Others

Cat.No: T15052

Target: NOD-like Receptor (NLR), NOD

N-(3-Aminopropyl)cyclohexylamine

Cat.No: T35878

Target: Others

Cat.No: TP1856

Target: Beta Amyloid, STAT

Cat.No: T13320L

Target: Potassium Channel

Cat.No: T4330

Target: Chloride channel

Cat.No: T12421

Target: Sodium Channel

Cat.No: TQ0046

Synonym: JNJ-31001074

Target: Histamine Receptor

Cat.No: T0776

Synonym: ENT 38,吩噻嗪

Target: Dopamine Receptor, Antibacterial, Antibiotic, Antifungal

Cat.No: T9694

Synonym: CVL-231

Target: AChR

Cat.No: T9149

Synonym: 2B-Act,2B Act

Target: PERK

VU591 hydrochloride

Cat.No: T13320

Target: Potassium Channel

Cat.No: T8944

Target: Calcium Channel

Cat.No: T4497

Synonym: 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine

Target: Others

Vecuronium bromide

Cat.No: T1594

Synonym: ORG NC 45,维库溴铵

Target: AChR

Cat.No: T0082

Synonym: R33812,多潘立酮

Target: Dopamine Receptor

Cat.No: T8930

Synonym: KUC103479N-02

Target: CDK, Ras

Cat.No: T1476

Synonym: SND 919,普拉克索

Target: Dopamine Receptor

Cat.No: T4074

Synonym: GSK872,GSK'872,GSK2399872A

Target: RIP kinase

PRE-084 hydrochloride

Cat.No: T3198L

Target: Sigma receptor

Cat.No: T6950

Synonym: NSC 216666

Target: AChR

NS8593 hydrochloride

Cat.No: T12256

Synonym: NS8593 HCl

Target: Potassium Channel

GW791343 dihydrochloride

Cat.No: T7805

Synonym: GW791343 (HCl)

Target: P2X Receptor

PF-CBP1 hydrochloride

Cat.No: T3217

Synonym: PF-CBP1 HCl

Target: Epigenetic Reader Domain, Histone Acetyltransferase

Pramipexole dihydrochloride hydrate

Cat.No: T6951

Synonym: Pramipexole 2HCl Monohydrate,普拉克索盐酸盐水合物,Mirapex,普拉克索

Target: Dopamine Receptor

Cat.No: T15247

Synonym: NSC 116966

Target: cAMP

SCH-23390 hydrochloride

Cat.No: T4369

Synonym: R-(+)-SCH23390 hydrochloride

Target: Potassium Channel, Dopamine Receptor, 5-HT Receptor

Cat.No: T15684

Target: NMDAR, iGluR

GW791343 trihydrochloride

Cat.No: T6526

Synonym: GW791343 3HCl

Target: P2X Receptor

SCH-23390 maleate

Cat.No: T12865

Synonym: R-(+)-SCH-23390 maleate

Target: Potassium Channel, Dopamine Receptor, 5-HT Receptor

Cat.No: T68063

Synonym: DU 29840

Target: Others

Clozapine Analogues

Cat.No: T84365

Target: Others

Cat.No: T26890

Synonym: BP-14979,BP1,4979,BP-1,4979,BP 1,4979,BP 14979

Target: Dopamine Receptor

Org-13011 fumarate

Cat.No: T28258

Synonym: Org13011,Org 13011

Target: 5-HT Receptor

Cat.No: T27838

Synonym: RO413696,RO-413696,RO41-3696,RO 413696,Ro 41-3696,Ro-41-3696

Target: GABA Receptor

Glutaminyl Cyclase Inhibitor 1

Cat.No: T11424

Target: Guanylate cyclase

Cat.No: T15553

Synonym: NKY 722

Target: Calcium Channel

COG-1410 acetate

Cat.No: T30998L

Synonym: COG-1410 acetate(878009-24-6 Free base)

Target: Apoptosis

GYKI 53655 hydrochloride

Cat.No: T15456

Synonym: GYKI53655 hydrochloride,LY300168 hydrochloride

Target: GluR

Cat.No: T13963

Synonym: NSC294836

Target: Others

Cat.No: T15655

Target: Adenosine Receptor

Cat.No: T14974

Synonym: Cytenamide,AY-15613

Target: Others

Delucemine Hydrochloride

Cat.No: T27143

Synonym: NPS 1506,Delucemine,Delucemine HCl,NPS1506,NPS-1506

Target: NMDAR

Cat.No: T22736

Synonym: 3,3'-Dimethoxybenzaldazine

Target: GluR

Cat.No: T24840

Synonym: STS E412,STSE412

Target: Others

Cat.No: T22850

Synonym: ICI 204448,ICI204448,ICI-204448

Target: Opioid Receptor

Cat.No: T26119

Synonym: Romifidinum

Target: Adrenergic Receptor

Cat.No: T31354

Synonym: V 285,V-285,V285

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1045	Trimipramine maleate Surmontil maleate,马来酸三甲丙咪嗪,三甲丙咪嗪马来酸盐	Dopamine Receptor; 5-HT Receptor; Antibacterial; Adrenergic Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Trimipramine maleate (Surmontil maleate) 是一种 5-HT 受体拮抗剂，对 5-HT1C、5-HT2和 5-HT1A 受体的 pKi 值分别为 6.39、8.10和 4.66。
T8392	L(+)-Asparagine monohydrate	Endogenous Metabolite	Metabolism
	L(+)-Asparagine monohydrate 是一种非必需氨基酸，参与组织细胞功能的神经和代谢调节。
T37177	Norcholic Acid	Others	Others
	Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,4
T8790	1-Methylhistamine dihydrochloride	Endogenous Metabolite	Metabolism
	1-Methylhistamine dihydrochloride 是组胺代谢物。
TQ0295	Coumestrol 拟雌内酯,考迈斯托醇	Estrogen Receptor/ERR	Endocrinology/Hormones
	Coumestrol 是一种大豆产品中存在的植物雌激素。它抑制ES2细胞增殖的IC50值为50 μM。它可用于癌症，神经障碍和自身免疫疾病的研究。
T4S1869	12-Epinapelline 12-表欧乌头碱,12-表-欧乌头碱	Others	Others
	12-Epinapelline 是一种二萜生物碱，分离自Aconitum baikalense 中。它具有抗炎作用，能刺激成纤维细胞前体克隆的生长。
T2S0531	Pinoresinol dimethyl ether (+)-Eudesmin,松脂素二甲醚	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Pinoresinol dimethyl ether 是一种非酚性呋喃木质素，从 Magnolia kobus 茎皮中分离得到，具有神经活性。它可刺激上游 MAPK、PKC 和 PKA 通路，诱导 PC12 细胞神经突起生长。
T5076	L-Allothreonine L-别苏氨酸,L-allo-Threonine	Others; Endogenous Metabolite	Metabolism; Others
	L-Allothreonine (L-allo-Threonine) 是内源性代谢产物的一种。
T66582	6-Methylnicotinamide	Endogenous Metabolite	Metabolism
	6-Methylnicotinamide 是烟酰胺的衍生物，是一种内源性代谢物。在脑出血 (ICH) 急性期， 6-Methylnicotinamide 突然增加会加剧神经损伤。6-Methylnicotinamide 可用于制作共晶体/盐。
T4887	3-Amino-2-methylpropanoic acid DL-3-AMINOISOBUTYRIC ACID,3-氨基异丁酸,α-Methyl-β-alanine	Endogenous Metabolite	Metabolism
	3-Amino-2-methylpropanoic acid (α-Methyl-β-alanine) 是 N-carbamyl-beta-aminoisobutyric acid 经 enzyme Beta-ureidopropionase (EC 3.5.1.6)转化后的产物，是嘧啶降解的最后一步。-尿嘧啶丙酸酶缺乏症是一种与神经异常相关的嘧啶降解的先天性错误。
T32614	L-Clausenamide (-)-Clausenamide	Microtubule Associated	Cytoskeletal Signaling
	L-Clausenamide 是从黄皮 (Clausena lansium (Lour) skeels) 的树叶中提取出来的生物碱，可用于提高认知功能。L-Clausenamide 对β-淀粉样蛋白 (Aβ) 毒性有抑制作用，通过抑制 tau 蛋白磷酸化阻止神经纤维缠结的形成。L-Clausenamide 具有神经保护活性，可用于调节 Aβ25-35 引发的刺激。L-Clausenamide 可用于研究阿尔兹海默症类的神经系统疾病。
T7984	2-Hydroxyflavanone	Others	Others
	2-Hydroxyflavanone 是一种天然存在的黄酮类化合物，存在于许多植物和水果中。它具有抗氧化、抗炎和抗肿瘤的活性，可以清除自由基，减少炎症，并抑制肿瘤细胞的生长，还具有治疗糖尿病、肥胖症、心血管疾病和神经系统疾病等多种疾病的潜力。
T3578	Pyridoxal phosphate PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate	Reverse Transcriptase; Endogenous Metabolite	Metabolism; Microbiology/Virology
	Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式，可抑制逆转录酶活性，用于研究迟发性运动障碍症。
T16165	Myriocin ISP-I,Thermozymocidin	HCV Protease; Antifungal	Microbiology/Virology; Proteases/Proteasome
	Myriocin (Thermozymocidin) 是一种从 Myriococcum albomyces 中得到的代谢产物，是一种丝氨酸-棕榈酰转移酶 (SPT) 抑制剂,具有潜在的抗肿瘤抗癌和抗寄生虫活性，通过 PI3K/Akt/mTOR 通路调节巨噬细胞极化和功能来抑制肿瘤生长。Myriocin 抑制 HCV 感染，可用于研究神经病变和真菌感染。
TN4368	Kaempferol-3,7-di-O-β-glucoside Kaempferol 3,7-di-O-glucoside	Glucosidase; Amylase	Metabolism
	Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) 是一种来自 Morettia philaena 的黄酮醇，对 α-淀粉酶 (α-amylase)、α-葡萄糖苷酶 (α-glucosidase) 和乙酰胆碱酯酶 (Acetylcholinesterase) 具有抑制作用。Kaempferol-3,7-di-O-β-glucoside 具有神经保护活性，可减缓分化神经元细胞 SH-SY5Y 免受 Amyloid β 肽诱导的损伤。Kaempferol-3,7-di-O-β-glucoside 可用于研究阿尔茨海默氏症类的神经系统疾病。
T4S2126	Ginkgetin 银杏双黄酮,银杏素	Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Ginkgetin 是从银杏叶中分离得到的一种双黄酮，具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂，IC50值为 5.92 μM。
T3011	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine,犬尿氨酸	Others; Endogenous Metabolite	Metabolism; Others
	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是一种酮类和氨基酸衍生物，具有多种生物功能，包括血管舒张、免疫调节和神经调节活性。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是烟酸的前体。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 的异常产生与神经系统疾病相关的认知缺陷和抑郁症状有关。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 在某些类型的癌细胞中过度表达，可能被用作评估癌症风险的生物标志物。
TN2299	Vindesine	Others	Others
	Vindesine is a microtubule inhibitor and widely used to treat malignancies. Vindesine neuropathy seems to be the cause of the patient's neurological symptoms.
T82341	Ganglioside GM1
	Ganglioside GM1，一种神经节苷脂家族成员，用于神经系统疾病研究。同时，它作为霍乱毒素 1 的功能性组织受体。
T75700	Longistyline A	Others	Others
	Longistyline A (Longistylin A) 是一种天然二苯乙烯，可从木豆中提取。Longistyline A 对耐甲氧西林金黄色葡萄球菌具有抑菌效应，MIC 值为 1.56 μg/mL。Longistyline A 具有神经保护作用，可用于感染和神经系统疾病的研究。
TN7261	Tridocosahexaenoylglycerol TG-DHA,Meganol D	Others	Others
	Tridocosahexaenoylglycerol (TG-DHA)是一种改善小鼠自身免疫性脑脊髓炎的口服有效膳食补充剂，展现出对神经退行性疾病的有益作用，并能改善糖尿病视网膜病变黄斑功能。该化合物在神经系统性疾病、炎症免疫疾病以及代谢性疾病研究中具有应用潜力。
TN3364	Agrimonolide	Apoptosis; Dehydrogenase; p38 MAPK; ROS; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; MAPK; Metabolism; Stem Cells
	Agrimonolide 是一种来自异香豆素的化合物，主要存在于草药Agrimonia pilosa Ledeb 中，具有显著的生物活性。Agrimonolide 通过抑制脂多糖（LPS）诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平，可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1，对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是，Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制，同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡，同时增加活性氧（ROS）和总铁的水平。Agrimonolide 很容易穿过血脑屏障，表明其在神经系统疾病的治疗应用方面具有潜力。

天然产物

Trimipramine maleate

Cat.No: T1045

Synonym: Surmontil maleate,马来酸三甲丙咪嗪,三甲丙咪嗪马来酸盐

Target: Dopamine Receptor, 5-HT Receptor, Antibacterial, Adrenergic Receptor, Norepinephrine, Histamine Receptor

L(+)-Asparagine monohydrate

Cat.No: T8392

Target: Endogenous Metabolite

Cat.No: T37177

Target: Others

1-Methylhistamine dihydrochloride

Cat.No: T8790

Target: Endogenous Metabolite

Cat.No: TQ0295

Synonym: 拟雌内酯,考迈斯托醇

Target: Estrogen Receptor/ERR

12-Epinapelline

Cat.No: T4S1869

Synonym: 12-表欧乌头碱,12-表-欧乌头碱

Target: Others

Pinoresinol dimethyl ether

Cat.No: T2S0531

Synonym: (+)-Eudesmin,松脂素二甲醚

Target: Others, PKC

L-Allothreonine

Cat.No: T5076

Synonym: L-别苏氨酸,L-allo-Threonine

Target: Others, Endogenous Metabolite

6-Methylnicotinamide

Cat.No: T66582

Target: Endogenous Metabolite

3-Amino-2-methylpropanoic acid

Cat.No: T4887

Synonym: DL-3-AMINOISOBUTYRIC ACID,3-氨基异丁酸,α-Methyl-β-alanine

Target: Endogenous Metabolite

Cat.No: T32614

Synonym: (-)-Clausenamide

Target: Microtubule Associated

2-Hydroxyflavanone

Cat.No: T7984

Target: Others

Pyridoxal phosphate

Cat.No: T3578

Synonym: PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate

Target: Reverse Transcriptase, Endogenous Metabolite

Cat.No: T16165

Synonym: ISP-I,Thermozymocidin

Target: HCV Protease, Antifungal

Kaempferol-3,7-di-O-β-glucoside

Cat.No: TN4368

Synonym: Kaempferol 3,7-di-O-glucoside

Target: Glucosidase, Amylase

Cat.No: T4S2126

Synonym: 银杏双黄酮,银杏素

Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

Cat.No: T3011

Synonym: Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine,犬尿氨酸

Target: Others, Endogenous Metabolite

Cat.No: TN2299

Target: Others

Ganglioside GM1

Cat.No: T82341

Cat.No: T75700

Target: Others

Tridocosahexaenoylglycerol

Cat.No: TN7261

Synonym: TG-DHA,Meganol D

Target: Others

Cat.No: TN3364

Target: Apoptosis, Dehydrogenase, p38 MAPK, ROS, JAK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02284	HN1 Protein, Mouse, Recombinant (His) hematological and neurological expressed 1	Mouse	E. coli
	HN1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.3 kDa and the accession number is P97825.
TMPY-06802	HSV 2 (strain 333) Glycoprotein D/gD Protein (His)	HSV2	HEK293 Cells
	Herpes simplex viruses (human herpesviruses types 1 and 2) commonly cause recurrent infection affecting the skin, mouth, lips, eyes, and genitals. Herpes simplex virus type 2 (HSV-2) infection is responsible for significant neurological morbidity, perhaps more than any other virus. Herpes simplex virus type 2–associated neurological disease may result from primary infection or reactivation of latent HSV-2. Common severe infections include encephalitis, meningitis, neonatal herpes, and, in immun...
TMPK-01049	CLEC7A Protein, Mouse, Recombinant (hFc) CLECSF12,DC-associated C-type lectin 1,Dectin-1,Beta-glucan ...	Mouse	HEK293 Cells
	Dendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin receptor (CLR). Dectin-1 signaling axis has been suggested to be targeted as an effective therapeutic strategy for cancers. Dectin-1 has also been elucidated ascetically in the heart, respiratory, intestinal, neurological and developmental disorders.
TMPJ-01002	SGSH Protein, Human, Recombinant (His) SGSH,N-Sulphoglucosamine Sulphohydrolase,Sulfoglucosamine Su...	Human	HEK293 Cells
	N-Sulphoglucosamine Sulphohydrolase (SGSH) is an important member of the sulfatase family which is involved in the degradation of heparin sulfate. SGSH binds one calcium ion per subunit as a cofactor. SGSH catalyzes N-sulfo-D-glucosamine and H2O to D-glucosamine and sulfate. SGSH deficiency is result in mucopolysaccharidosis type 3A (MPS3A), a recessive lysosomal storage disease characterized by neurological dysfunction but relatively mild somatic manifestations.
TMPK-00699	FAM19A5 Protein, Human, Recombinant (His) Chemokine-like protein TAFA-5,UNQ5208,Tafa5,QLLK5208,Fam19a5	Human	E. coli
	FAM19A5 is a secretory protein that is predominantly expressed in the brain. Although the FAM19A5 gene has been found to be associated with neurological and/or psychiatric diseases, only limited information is available on its function in the brain. FAM19A5 plays a role in nervous system development from an early stage and increases its expression in response to pathological conditions in subsets of neurons and OPCs of the brain. FAM19A5 Protein, Human, Recombinant (His) is expressed in E. coli ...
TMPK-01125	FAM19A5 Protein, Mouse, Recombinant (His) Fam19a5,QLLK5208,Tafa5,Chemokine-like protein TAFA-5,UNQ5208	Mouse	E. coli
	FAM19A5 is a secretory protein that is predominantly expressed in the brain. Although the FAM19A5 gene has been found to be associated with neurological and/or psychiatric diseases, only limited information is available on its function in the brain. FAM19A5 plays a role in nervous system development from an early stage and increases its expression in response to pathological conditions in subsets of neurons and OPCs of the brain. FAM19A5 Protein, Mouse, Recombinant (His) is expressed in E. coli ...
TMPY-03332	PRTFDC1 Protein, Human, Recombinant (His) HHGP,PRTFDC1,phosphoribosyl transferase domain containing 1	Human	E. coli
	PRTFDC1 is a member of the purine/pyrimidine phosphoribosyltransferase family. It can bind GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). The epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis. PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse and has important implications for unraveling the molecular etiology of lesch-Nyhan disease(LND). LND is a sever...
TMPJ-00295	NgR Protein, Mouse, Recombinant (hFc) Nogo-66 Receptor,Nogo Receptor,NgR,RTN4R,NOGOR,Reticulon-4 R...	Mouse	HEK293 Cells
	Nogo Receptor (NgR) is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family. Human NgR is predominantly expressed in neurons and their axons in the central nervous systems. As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG) and myelin oligodendrocyte glycoprotein (OMG), NgR mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. NgR may be prop...
TMPJ-01022	SUMO3 Protein, Human, Recombinant (HEK293, His) SMT3 homolog 1,Smt3A,Small ubiquitin-related modifier 3,Ubiq...	Human	HEK293 Cells
	Small ubiquitin-like modifier (SUMO), also known as SUMO homologue and SMT3, is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various intracellular target proteins as a way to alter their function, location, and/or half-life. Small ubiquitin-like modifiers include SUMO1, SUMO2, SUMO3, and SUMO4. Except for SUMO4, all other SUMOs are ubiquitously expressed, including in the brain. In human, SUMO2 and SUMO3 are two highly homologous proteins, collect...
TMPY-03852	Dopamine beta-Hydroxylase Protein, Human, Recombinant (His) dopamine β-hydroxylase (dopamine β-monooxygenase),Dopamine β...	Human	HEK293 Cells
	DBH is a 29 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH contains our identical subunits, and its activity requires ascorbate as a cofactor. It functions in in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only transmitter synthesized inside vesicles. DBH has been shown to be associated ...
TMPY-03969	SUSD4 Protein, Human, Recombinant (mFc) sushi domain containing 4,PRO222	Human	HEK293 Cells
	SUSD4, also known as sushi domain-containing protein 4, is a hypothetical cell surface protein whose tissue distribution and function are completely unknown. SUSD4 is detectable in murine brains, eyes, spinal cords, and testis but not other tissues. In brains, SUSD4 is highly expressed in the white matter on oligodendrocytes/axons, and in eyes, it is exclusively expressed on the photoreceptor outer segments. In in vitro complement assays, SUSD4 augments the alternative but not the classical path...
TMPY-03452	PTS Protein, Human, Recombinant (His) PTPS,PTS,6-pyruvoyltetrahydropterin synthase	Human	E. coli
	PTS(6-pyruvoyltetrahydropterin synthase) belongs to the PTPS family. It catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia....
TMPY-02025	CPLX2 Protein, Human, Recombinant (His) CPX-2,Hfb1,921-L,complexin 2,CPX2	Human	E. coli
	Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals. Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Complexins are unable to bind to monomeric SNARE proteins but bind with high affinity to ternary SNARE complexes and with lower affinity to target ...
TMPJ-00495	ISG15 Protein, Human, Recombinant (His) ISG15,Ubiquitin Cross-Reactive Protein,G1P2,Interferon-Induc...	Human	E. coli
	Ubiquitin-Like Protein ISG15 (ISG15) is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermed...
TMPY-01290	CHIT1 Protein, Human, Recombinant (His) chitinase 1 (chitotriosidase),CHITD,CHI3,CHIT	Human	HEK293 Cells
	Chitotriosidase, also known as Chitinase-1 and CHIT1, is a member of the glycosyl hydrolase 18 family and Chitinase class II subfamily. It is a member of the mammalian chitinase family, structurally homologous to chitinases from other species, is synthesized and secreted by specifically activated macrophages. Chitotriosidase is a polymer of N-acetylglucosamine. Serum and plasma chitotriosidase activity is usually measured as the first step in diagnosis of Gaucher disease. Monitoring chitotriosid...

重组蛋白

HN1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02284

Species: Mouse

Expression System: E. coli

HSV 2 (strain 333) Glycoprotein D/gD Protein (His)

Cat.No: TMPY-06802

Species: HSV2

Expression System: HEK293 Cells

CLEC7A Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01049

Species: Mouse

Expression System: HEK293 Cells

SGSH Protein, Human, Recombinant (His)

Cat.No: TMPJ-01002

Species: Human

Expression System: HEK293 Cells

FAM19A5 Protein, Human, Recombinant (His)

Cat.No: TMPK-00699

Species: Human

Expression System: E. coli

FAM19A5 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01125

Species: Mouse

Expression System: E. coli

PRTFDC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03332

Species: Human

Expression System: E. coli

NgR Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00295

Species: Mouse

Expression System: HEK293 Cells

SUMO3 Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPJ-01022

Species: Human

Expression System: HEK293 Cells

Dopamine beta-Hydroxylase Protein, Human, Recombinant (His)

Cat.No: TMPY-03852

Species: Human

Expression System: HEK293 Cells

SUSD4 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03969

Species: Human

Expression System: HEK293 Cells

PTS Protein, Human, Recombinant (His)

Cat.No: TMPY-03452

Species: Human

Expression System: E. coli

CPLX2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02025

Species: Human

Expression System: E. coli

ISG15 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00495

Species: Human

Expression System: E. coli

CHIT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01290

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0028	2-(1-(methyl-d3)-1H-imidazol-4-yl)ethan-1-amine 2HCl 1-Methylhistamine-d3 Dihydrochloride
	2-(1-(methyl-d3)-1H-imidazol-4-yl)ethan-1-amine 2HCl 是 2-(1-(methyl)-1H-imidazol-4-yl)ethan-1-amine 2HCl 的氘代化合物。2-(1-(methyl)-1H-imidazol-4-yl)ethan-1-amine 2HCl 的 CAS 号为 6481-48-7。1-Methylhistamine dihydrochloride 是组胺代谢物。
TMIJ-0052	Propionicacid-d5
	Propionicacid-d5 是 Propionicacid 的氘代化合物。Propionicacid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中，并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中，作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。
TMIJ-0054	Propionic-2,2-d2 acid
	Propionic-2,2-d2 acid 是 Propionic acid 的氘代化合物。Propionic acid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中，并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中，作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。

同位素标记化合物

2-(1-(methyl-d3)-1H-imidazol-4-yl)ethan-1-amine 2HCl

Cat.No: TMIH-0028

Synonym: 1-Methylhistamine-d3 Dihydrochloride

Propionicacid-d5

Cat.No: TMIJ-0052

Propionic-2,2-d2 acid

Cat.No: TMIJ-0054

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