hmg 1

HMG-CoA Reductase-IN-1是一种HMG-CoA还原酶抑制剂，显示出高HMGR抑制活性及OATP1B1亲和力，具有pIC50值8.54和pKm值1.98。该化合物适用于高胆固醇血症的研究。

Mevastatin (ML236B) 是他汀类 HMG-CoA 还原酶抑制剂。它是一种降脂药，可诱导细胞凋亡，将癌细胞阻滞在 G0 G1期。它还可增加内皮型一氧化氮合酶的 mRNA 和蛋白质水平。它有抗肿瘤活性，用于心血管疾病的研究。

Rosuvastatin zinc salt (Rosuvastatin zinc)，为Rosuvastatin的含锌盐形态，属于HMG-CoA还原酶抑制剂类药物，常用于动脉粥样硬化的研究领域。

Hymeglusin 是一种选择性 3-羟基-3-甲基戊二酰辅酶 A (HMG-CoA) 合酶 1 抑制剂，也是一种抗生素，可降低 HL-60 和 KG-1 细胞中 BCL2 的表达水平，可用于研究白血病。

2-Hydroxy atorvastatin lactone, a metabolite of Atorvastatin, is an orally active HMG-CoA reductase inhibitor that efficiently reduces blood lipids [1][2].

Dim16是一种同时抑制PCSK9和HMG-CoAR的化合物，其对PCSK9的IC50为19 nM，并且能够阻断PCSK9与LDLR的结合，此作用的IC50为0.8 nM。Dim16还能提升HepG2细胞对LDL的吸收。

S-2E is a compound that functions as an orally active, noncompetitive inhibitor of both HMG-CoA reductase and acetyl-CoA carboxylase. It exhibits an anti-hyperlipidemic action, making it suitable for studying conditions such as familial hypercholesterolemia and mixed hyperlipidemia [1] [2].

Pitavastatin-d4 Sodium Salt 是 Pitavastatin Sodium Salt 的氘代化合物。Pitavastatin Sodium Salt 的 CAS 号为 574705-92-3。

Fluvastatin (sodium monohydrate) (XU 62-320 (sodium monohydrate))，作为首个全合成的 HMG-CoA 还原酶竞争性抑制剂，其 IC50 值为 8 nM。此外，Fluvastatin (sodium monohydrate) 通过 Nrf2 依赖的抗氧化途径，有效地保护血管平滑肌细胞免遭氧化压力的损害。

HMG499是有效，选择性的HMG-CoA 还原酶抑制剂，EC50为 0.41 μM。HMG499可消除他汀类药物诱导的HMGCR 积聚，并且降低血清胆固醇水平，减少动脉粥样硬化。

β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4]

(3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium 为Fluvastatin的一个3R,5S-立体异构体。该化合物(Fluvastatin (XU 62-320 free acid)) 是首个全合成、具有竞争性的HMG-CoA还原酶抑制剂，具有8 nM的IC50值。此外，Fluvastatin还能通过Nrf2依赖的抗氧化途径，保护血管平滑肌细胞不受氧化应激影响。

Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug discovery.[3][4]

N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) isoform CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4.1 1.Macwan, J.S., Ionita, I.A., and Akhlaghi, F.A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS)Anal. Bioanal. Chem.402(3)1217-1227(2012) 2.Bai, X., Wang, X.P., He, G.D., et al.Simultaneous determination of rosuvastatin, rosuvastatin-5 S-lactone, and N-desmethyl rosuvastatin in human plasma by UPLC-MS/MS and its application to clinical studyDrug Res. (Stuttg.)68(6)328-334(2018)

Ganoderenic acid K，一种从灵芝子实体分离得到的天然产物，对HMG-CoA还原酶(HMGCR)显示出强抑制作用，IC50值为16.5 μM。