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Search Results for " growth inhibitory "

Targets Recommended: Microtubule Associated Drug-Linker Conjugates for ADC

123

抑制剂 & 化合物

82

天然产物

20

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11917	Lys-SMCC-DM1 Lys-Nε-MCC-DM1	Microtubule Associated; Drug-Linker Conjugates for ADC	Antibody-drug Conjugate/ADC Related; Cytoskeletal Signaling
	DM1 是一种微管蛋白抑制剂。 Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) 是 DM1 的活性代谢物。
TQ0018	6-Amino-5-azacytidine	Antibacterial	Microbiology/Virology
	6-Amino-5-azacytidine 对大肠杆菌的生长有抑制作用。
T21804	GW 610	Others	Others
	GW 610 是一种抗肿瘤剂，能够选择性作用于肺癌、结肠癌和乳腺癌细胞系，具有抗癌活性。
T10104	3,4-Dihydroxybenzylamine hydrobromide NSC 263475 hydrobromide,3,4-二羟基苄胺·氢溴酸	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) 抑制黑色素瘤细胞中的 DNA 聚合酶活性，并在具有不同程度酪氨酸酶活性的黑色素瘤细胞系中显示出生长抑制活性。
T24897	TP0427736 TP427736,TP-0427736,TP-427736	TGF-beta/Smad	Stem Cells
	TP0427736 是一种有效的选择性 ALK5 抑制剂，IC50 为 2.72 nM，比对 ALK3 的抑制作用高 300 倍。 TP0427736 可降低人外根鞘细胞中 TGF-β 诱导的生长抑制，并延长小鼠毛囊中的生长期。
T16449	PD176252	Bombesin Receptor	GPCR/G Protein
	PD176252 是一种有效的 BB1 和 BB2 拮抗剂，对 BB1 和 BB2 受体具有抑制作用。PD176252 可当作一种小分子 BB2 抑制剂和 FPR1/FPR2 激动剂可以抑制多种癌细胞的生长和增殖。
TP2236L	Cortistatin-8 acetate Cortistatin-8 acetate(485803-62-1 Free base)	GHSR	GPCR/G Protein
	Cortistatin-8 acetate 是一种皮质抑素类似物，是一种GHS-R拮抗剂，对生长激素促分泌素受体有抑制作用。Cortistatin-8 acetate 是一种合成皮质抑素衍生的生长素释放肽受体配体，不会改变人类对酰化生长素释放肽或海沙瑞林的内分泌反应。
T9573	GSK3685032	DNA Methyltransferase	Chromatin/Epigenetic
	GSK-3685032 是一种非时间依赖、非共价、选择性的、可逆的DNMT1抑制剂，IC50=0.036 μM。它诱导 DNA 甲基化丧失、转录激活和癌细胞生长抑制。
T4272	4-Hydroxyquinoline 4-羟基喹啉,4-Quinolinol,Quinolin-4-Ol	Antibacterial	Microbiology/Virology
	4-Hydroxyquinoline (4-Quinolinol) 是一种具有抗菌活性的羟基化喹啉衍生物。它显示出对肠道细菌的生长抑制作用。它也可以用作光生氧物质的牺牲清除剂。
TP1410	Cecropin A	Antibacterial; Antibiotic	Microbiology/Virology
	Cecropin A 是37个氨基酸组成的线性多肽，表现出抗菌、抗炎和抗肿瘤的功效。
T77437	Telisotuzumab ABT-700,Mab-224G11	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Telisotuzumab(ABT-700) 是一种人源化重组抗体，靶向治疗性肝细胞生长因子受体（MET）的抗体，对 c-Met 具有很高的亲和力。Telisotuzumab 对 c-Met 信号传导具有抑制作用且具有抗肿瘤活性。
T11800	L-803087	Somatostatin	GPCR/G Protein
	L-803087 是一种具有高效性和选择性的生长抑素 sst4 受体激动剂，对 sst4 的 Ki 值为 0.7 nM，比其他生长抑素受体的选择性高 280 倍以上。L-803087 在体外诱导 AMPA 介导的海马突触反应，在体内增加了海藻酸盐促使的小鼠癫痫发作。
T21854	Proteasome inhibitor IX PS-IX,AM114	Proteasome	Proteases/Proteasome; Ubiquitination
	Proteasome inhibitor IX (PS-IX) 是 Chalcone 的一种衍生物，对20S 蛋白酶体的胰凝乳蛋白酶样活性有抑制作用，IC50约为 1 μM。它抑制 HCT116 p53+/+细胞生长，IC50为 1.49 μM，显示出有效的抗癌活性。
T73582	EB1	MNK	MAPK
	EB1 是一种具有有效性和选择性的 MNK 激酶抑制剂，对 MNK1和 MNK2 具有抑制作用 IC50 分别为 0.69 μM 和 9.4 μM。EB1 抑制癌细胞的生长，促进细胞凋亡，抑制 eIF4E 磷酸化。
T36310	AKT-IN-6 INCB-047775	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT-IN-6 (INCB-047775)对ATK 有抑制作用。Akt 是对生长因子、细胞因子和其他细胞刺激的细胞信号传导的重要组成部分。Akt 的异常激活与2型糖尿病和癌症的发生密切相关。
T39392L	C-Type Natriuretic Peptide (1-22) acetate（human） C-Type Natriuretic Peptide (CNP) (1-22), human acetate(1966153-17-2 Free base)	Others	Others
	C-Type Natriuretic Peptide (CNP) (1-22), human acetate 是一种利钠肽受体 B (NPR-B) 的激动剂，一种内皮衍生的松弛剂和生长抑制因子。 C-Type Natriuretic Peptide (CNP) (1-22), human acetate 抑制由组胺和 5-HT 或直接由毛喉素刺激的 cAMP 合成。
T26873	BMY-27709 BMY 27709,BMY27709	Influenza Virus	Microbiology/Virology
	BMY-27709 是一种流感病毒生长抑制剂，对 A/WSN/33 病毒生长的 IC50 值为 3-8 μM，对流感病毒的部分亚型也展现出抑制活性。BMY-27709 对 H1 和 H2 病毒感染的早期起作用，通过抑制血凝素蛋白展现其抗病毒活性。然而，BMY-27709 对 H3 亚型病毒以及 B 型/Lee/40 流感病毒没有作用。
T76756	Parsatuzumab RG 7414,Anti-EGFL7,MEGF0444A,MEGF-0444A,RO-5490248,M0444A	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Parsatuzumab (RG 7414) 是一种人源化靶向 EGFL7 的单克隆抗体，也可作为一种免疫调节剂使用。Parsatuzumab 选择性抑制 EGFL7 与内皮细胞之间的相互作用，对内皮生长因子 (VEGF) 有抑制作用。Parsatuzumab 长期其他化合物联合联合使用来研究直肠癌
T64124	Sunvozertinib DZD9008,DZD 9008,DZD-9008	EGFR; BTK	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Sunvozertinib (DZD9008) 是一种有效的 ErbBs 和 BTK 抑制剂，对EGFR、Her2和突变型表皮生长因子有抑制作用。 Sunvozertinib 显示 EGFR 外显子 20 NPH 插入、EGFR 外显子 20 ASV 插入、EGFR L858R 和 T790M 突变以及 Her2 外显子 20 YVMA 和 EGFR WT A431 有抑制作用， IC50 分别为 20.4、20.4、1.1、7.5 和 80.4 nM 。
T21831	UCM05 G28UCM	Fatty Acid Synthase	Metabolism
	UCM05 (G28UCM) (G28UCM) 是一种有效的脂肪酸合酶 (FASN) 抑制剂，对 HER2+ 乳腺癌异种移植物具有作用活性，且在抗 HER2 耐药细胞系中具有活性。UCM05 是一种丝状温度敏感蛋白 Z (FtsZ) 抑制剂，可抑制革兰氏阳性菌B. subtilis 生长，MIC 值为 100 μM，但对革兰氏阴性菌E. coli 缺乏活性。
T76863	Elezanumab AE12-1Y-QL,ABT-555	TGF-beta/Smad	Stem Cells
	Elezanumab(ABT-555) 是一种有效的人抗 RGMa 单克隆抗体。Elezanumab 通过 SMAD1/5/8 通路发挥对 RGMa 介导的 BMP 信号传导的抑制作用，IC50 约为 97 pM。在神经元损伤和脱髓鞘模型中，Elezanumab 促进神经再生、神经保护和神经恢复。Elezanumab 促进皮质脊髓轴突生长为脊髓灰质，并增强腹角的血清素能神经支配，形成颈部病变尾部的突触连接。
T24457	Methotrexate-gamma-aspartate	Others	Others
	Methotrexate-gamma-aspartate has growth inhibitory effects. It is used in antibody-targeted liposomes.
T24933	VCC234718 VCC-234718,VCC 234718	Others	Others
	VCC234718 is an IMPDH inhibitor. VCC234718 showed growth inhibitory activity against Mycobacterium tuberculosis. VCC234718 inhibits Mtb GuaB2 (Ki: 100 nM).
T71875	OM-137	Others	Others
	OM137 is an inhibitor of Aurora kinases. which is growth inhibitory to cultured cells when applied at high concentration and potentiates the growth inhibitory effects of subnanomolar concentrations of paclitaxel.
T71312	Litophynin C	Others	Others
	Litophynin C is an Insect Growth Inhibitory Diterpenoid from a Soft Coral Litophyton sp.
T10551	Bithionol sulfoxide	Others	Others
	Bithionol sulfoxide is a clinically approved antiparasitic drug with the inhibitory against solid tumor growth in several preclinical cancer models.
T69511	Diospyrin	Others	Others
	Diospyrin is a plant product that has significant inhibitory effect on the growth of Leishmania donovani promastigotes.
T71414	Litophynin A	Others	Others
	Litophynin A is an insect Growth Inhibitory Diterpenoids from the Soft Coral Litophyton sp.
T71862	GPR120-IN-1	Others	Others
	GPR120-IN-1 is a novel GPR120 inhibitor, showing ~90% inhibitory effects on cell growth with micromolar affinities against SW480.
T70240	Caparratriene	Others	Others
	Caparratriene is a new sesquiterpene hydrocarbon isolated from Ocotea caparrapi with potential for significant growth inhibitory activityagainst CEM leukemia cells
T69260	Genistein Diglucuronide	Others	Others
	Genistein Diglucuronide is a metabolite of Genistein which exhibits specific inhibitory activity against tyrosine kinases including autophosphorylation of epidermal growth factor receptor kinase.
T69863	Dihydrogenistein	Others	Others
	Dihydrogenistein is a derivative of Genistein -- a compound that exhibits specific inhibitory activity against tyrosine kinases including autophosphorylation of epidermal growth factor receptor kinase.
T71060	IST-622	Others	Others
	IST-622 is a unique topoisomerase inhibitor, showing significant growth-inhibitory effects against large-cell lung cancer (Lu-116) and gastric adenocarcinoma (St-4).
T69209	ZK-304709	Others	Others
	ZK-304709 is a potent multi-target tumor growth inhibitor with IC50 = nanomolar inhibitory activity to cyclin-dependent kinases 1, 2, 4, 7 and 9, as well as vascular endothelial growth factor receptor tyrosine kinase 1-3 and of platelet-derived growth factor receptor beta tyrosine kinase.
T70894	Azamitosene	Others	Others
	Azamitosene is a DNA cleaving agent exhibiting G and A base specificity. Azamitosene may exhibit a growth inhibitory effect on human gastric cancer cells.
T62802	Indoluidin E	Others	Others
	Indoluidin E 能够选择性地抑制 DHODH，且对癌细胞生长具有抑制作用。
T36750	Didesmethylrocaglamide	Others	Others
	Didesmethylrocaglamide, a Rocaglamide derivative, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor that exhibits strong growth-inhibitory effects, with an IC50 of 5 nM. It hinders several growth-promoting signaling pathways and triggers apoptosis in tumor cells, demonstrating antitumor activity[1].
T69264	Aristeromycin diphosphate	Others	Others
	Aristeromycin diphosphate is an inhibitor of S-adenosylhomocysteine hydrolase (AHCY), inducing miR-26a and regulating oncogenic EZH2 expression, showing high inhibitory activity against AHCY, and causing growth inhibition of prostate cancer.
T69293	Lasonolide A	Others	Others
	Lasonolide A is a potential anticancer molecule isolated from the marine sponge Forcepia sp., with nanomolar growth inhibitory activity and a unique cytotoxicity profile against the National Cancer Institute 60-cell-line screen
T39001	FGFR-IN-1	Others	Others
	FGFR-IN-1 is a highly effective inhibitor targeting the Fibroblast Growth Factor Receptor (FGFR) group, comprising FGFR1, FGFR2, and FGFR3, with an impressive inhibitory concentration (IC 50) of less than 100 nM (US20130338134A1, example 219).
T28007	MDPD	Others	Others
	MDPD is an enhancer of the N-acylethanolamine degrading enzyme, fatty acid amide hydrolase, in Arabidopsis. MDPD alleviates the growth inhibitory effects of NAE 12:0, in part by enhancing the enzymatic activity of Arabidopsis FAAH (AtFAAH).
T39856	Purine riboside triphosphate PTP,Purine riboside triphosphate	Others	Others
	Purine riboside triphosphate, a derivative of purine riboside, exhibits structural similarity to adenosine. This naturally occurring base analog possesses inhibitory effects on carcinogenic growth, particularly in cancer ascites cells, by strongly impeding RNA and DNA synthesis.
T41133	Ursonic acid methyl ester	Others	Others
	Ursonic acid methyl ester, an esterified derivative of Ursolic acid, exhibits growth inhibitory activity against four tumor cell lines: HL-60, BGC, Bel-7402, and Hela, and the ED50 values for inhibition are >100 μg/ml.
T60555	Antiproliferative agent-3	Others	Others
	Antiproliferative agent-3 (comp 4) 对 MCF-7 癌细胞表现出良好的活性，IC50值为 0.19 nM。
T63460	Tropesin	Others	Others
	Tropesin 是一种非甾体抗炎剂 (NSAIA)，对绿色木霉的生长具有抑制作用。
T80339	Gallin
	Gallin是一种从蛋清提取的抗菌肽，在0.25 µM浓度时能够抑制Escherischia coli的生长。
T68209	Kopsoffinol	Others	Others
	Kopsoffinol is a bisindole alkaloid that has been shown to have in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells.
T83244	7Ethanol-10NH2-11F-Camptothecin	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	7Ethanol-10NH2-11F-Camptothecin 是一抗体-活性分子偶联物(ADC)，具有抑制肿瘤生长的功能，适用于癌症研究。
T61096	Antibacterial agent 95	Others	Others
	Antibacterial agent 95 (2-(quinoline-4-methoxy) acetamide), a new antituberculotic agent, exhibited a minimum inhibitory concentration (MIC) of only 0.3 μM against the reference strain of Mycobacterium tuberculosis H37Rv. Additionally, it effectively suppressed the growth of Mycobacterium tuberculosis in the macrophage model of tuberculosis infection.
T71534	CIA-1 hcl(452087-38-6 Free base)	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	CIA-1对核受体COUP-TFII 具有抑制作用，在前列腺癌细胞系中IC50范围从1.2μM 到7.6μM 之间。CIA-1在体外抑制多种前列腺癌细胞系的生长并抑制COUP-TFII 活性以调节其靶基因。CIA-1在体内对前列腺癌异种移植小鼠模型中的肿瘤生长具有抑制作用。

化合物

Cat.No: T11917

Synonym: Lys-Nε-MCC-DM1

Target: Microtubule Associated, Drug-Linker Conjugates for ADC

6-Amino-5-azacytidine

Cat.No: TQ0018

Target: Antibacterial

Cat.No: T21804

Target: Others

3,4-Dihydroxybenzylamine hydrobromide

Cat.No: T10104

Synonym: NSC 263475 hydrobromide,3,4-二羟基苄胺·氢溴酸

Target: Others, DNA/RNA Synthesis

Cat.No: T24897

Synonym: TP427736,TP-0427736,TP-427736

Target: TGF-beta/Smad

Cat.No: T16449

Target: Bombesin Receptor

Cortistatin-8 acetate

Cat.No: TP2236L

Synonym: Cortistatin-8 acetate(485803-62-1 Free base)

Target: GHSR

Cat.No: T9573

Target: DNA Methyltransferase

4-Hydroxyquinoline

Cat.No: T4272

Synonym: 4-羟基喹啉,4-Quinolinol,Quinolin-4-Ol

Target: Antibacterial

Cat.No: TP1410

Target: Antibacterial, Antibiotic

Cat.No: T77437

Synonym: ABT-700,Mab-224G11

Target: c-Met/HGFR

Cat.No: T11800

Target: Somatostatin

Proteasome inhibitor IX

Cat.No: T21854

Synonym: PS-IX,AM114

Target: Proteasome

Cat.No: T73582

Target: MNK

Cat.No: T36310

Synonym: INCB-047775

Target: Akt

C-Type Natriuretic Peptide (1-22) acetate（human）

Cat.No: T39392L

Synonym: C-Type Natriuretic Peptide (CNP) (1-22), human acetate(1966153-17-2 Free base)

Target: Others

Cat.No: T26873

Synonym: BMY 27709,BMY27709

Target: Influenza Virus

Cat.No: T76756

Synonym: RG 7414,Anti-EGFL7,MEGF0444A,MEGF-0444A,RO-5490248,M0444A

Target: VEGFR

Cat.No: T64124

Synonym: DZD9008,DZD 9008,DZD-9008

Target: EGFR, BTK

Cat.No: T21831

Synonym: G28UCM

Target: Fatty Acid Synthase

Cat.No: T76863

Synonym: AE12-1Y-QL,ABT-555

Target: TGF-beta/Smad

Methotrexate-gamma-aspartate

Cat.No: T24457

Target: Others

Cat.No: T24933

Synonym: VCC-234718,VCC 234718

Target: Others

Cat.No: T71875

Target: Others

Cat.No: T71312

Target: Others

Bithionol sulfoxide

Cat.No: T10551

Target: Others

Cat.No: T69511

Target: Others

Cat.No: T71414

Target: Others

Cat.No: T71862

Target: Others

Cat.No: T70240

Target: Others

Genistein Diglucuronide

Cat.No: T69260

Target: Others

Dihydrogenistein

Cat.No: T69863

Target: Others

Cat.No: T71060

Target: Others

Cat.No: T69209

Target: Others

Cat.No: T70894

Target: Others

Cat.No: T62802

Target: Others

Didesmethylrocaglamide

Cat.No: T36750

Target: Others

Aristeromycin diphosphate

Cat.No: T69264

Target: Others

Cat.No: T69293

Target: Others

Cat.No: T39001

Target: Others

Cat.No: T28007

Target: Others

Purine riboside triphosphate

Cat.No: T39856

Synonym: PTP,Purine riboside triphosphate

Target: Others

Ursonic acid methyl ester

Cat.No: T41133

Target: Others

Antiproliferative agent-3

Cat.No: T60555

Target: Others

Cat.No: T63460

Target: Others

Cat.No: T80339

Cat.No: T68209

Target: Others

7Ethanol-10NH2-11F-Camptothecin

Cat.No: T83244

Target: Others, ADC Cytotoxin

Antibacterial agent 95

Cat.No: T61096

Target: Others

CIA-1 hcl(452087-38-6 Free base)

Cat.No: T71534

Target: Gamma-secretase

Cat. No.	Product Name	Target	Signaling Pathways
TN1402	Arjungenin 阿江榄仁素,2ALPHA,19ALPHA,23-三羟基齐墩果酸	Antifection; Immunology/Inflammation related	Immunology/Inflammation; Microbiology/Virology
	Arjungenin, a triterpene derived from Terminalia arjuna, exhibits insect feeding-deterrent and growth inhibitory properties.
TN1028	Militarine	Others	Others
	Militarine 是一种糖苷化合物，分离自 Bletilla striata，能够抑制植物生长。
T4S0051	Coptisine sulfate	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine Sulfate 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T5S0689	Demethylwedelolactone 去甲蟛蜞菊内酯,去甲基蟛蜞内酯	Serine Protease	Proteases/Proteasome
	Demethylwedelolactone 是一种分离自 Eclipta alba 中的 coumestan 天然产物。它能抑制乳腺癌细胞的移动和侵袭，是一种有效的trypsin 抑制剂(IC50:3.0 μM)。
TN1433	Batatasin III	FAK; Others; Akt	Angiogenesis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Batatasin III 通过抑制上皮间质转化和 FAK-AKT 信号来抑制癌症迁移和侵袭，并具有抗癌活性。 Batatasin III 对整株生长有长期抑制作用，显示出抑制萌发活性。
TN2347	Methylsticin 麻醉椒苦素,Methysticin	Others	Others
	Methylsticin (Methysticin) 是一种卡瓦内酯，从卡瓦根中分离得到。它能够抑制破骨细胞形成的活性。
T2979	DL-Menthol DL-薄荷醇,Hexahydrothymol,(±)-Menthol,薄荷醇	GABA Receptor; AChE	Membrane transporter/Ion channel; Neuroscience
	DL-Menthol ((±)-Menthol) 是单萜醇 (–)-薄荷醇和 (+)-薄荷醇的外消旋混合物，已在大麻中发现。它与 GABAA 受体的激活有关。
T2978	Mogroside V	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Mogroside V 是三萜糖苷，是非糖类甜味剂，甜度比蔗糖甜高300倍。它具有抗氧化，抗糖尿病和抗癌作用。
TN1905	Magnolioside 七叶苷甲基醚,6-甲氧基香豆素-7-0-BETA-D-吡喃葡萄糖苷	Antifection	Microbiology/Virology
	Magnolioside 是分离自Angelica gigas Nakai(Umbelliferae) 中，对谷氨酸诱导的毒性有显著的神经保护作用。它显示出对金黄色葡萄球菌 CIP 53.154 的中等抗菌活性。它具有抗疟原虫活性，对氯喹敏感的恶性疟原虫菌株具有强烈的生长抑制作用。
T4S0998	Trifolirhizin 红车轴草根甙/三叶豆紫檀苷,三叶豆紫檀苷	TNF; Tyrosinase	Apoptosis; Proteases/Proteasome
	Trifolirhizin 是一种从苦参根中分离出的 pterocarpan 黄酮类化合物。它具有酪氨酸酶高抑制活性，IC50=506 μM。它具有抗炎和抗癌的潜能。
T7028	Licochalcone C LICOCHALCONEC,甘草查尔酮C	Phosphatase; Antioxidant; Glucosidase	Metabolism; oxidation-reduction
	Licochalcone C (LICOCHALCONEC) 能够抑制 α-葡萄糖苷酶，其对 α-葡萄糖苷酶的 IC50 <100 nM，对蛋白酪氨酸磷酸酶 1B 的 IC50=92.43 μM 。
T3864	Erianin	BCL; Antibacterial	Apoptosis; Microbiology/Virology
	Erianin 能抑制吲哚胺-2,3-双加氧酶诱导的肿瘤血管生成，可用作退烧药和止疼剂。
T3S2312	Poncirin 枸橘苷,Isosakuranetin-7-neohesperidoside	Apoptosis; Others	Apoptosis; Others
	Poncirin (Isosakuranetin-7-neohesperidoside) 是从三叶草中分离出来的一种天然产物，具有抗炎活性。它防止脂肪生成，增强间充质干细胞中的成骨细胞分化，增加骨矿物质密度，改善小梁微结构，可能反映 GIO 小鼠的骨形成增加和骨吸收减少。
T3923	Calycosin Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮	Apoptosis; Tyrosinase	Apoptosis; Proteases/Proteasome
	Calycosin (Cyclosin) 是一抗氧化和抗炎症活性天然产物。
T2S1865	Octyl gallate Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯	Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction
	Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用，有选择性和敏感性的荧光特性，广泛用作食品添加剂。它对 HSV-1，水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。
TL0008	Gigantol	Wnt/beta-catenin; Glucosidase	Cytoskeletal Signaling; Metabolism; Stem Cells
	Gigantol 是一种联苄基化合物，从几种药用兰花中获得，是一种Wnt/β-catenin 通路抑制剂，具有抗肿瘤活性。
T3S0737	Flavokawain A 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A	Apoptosis; p38 MAPK	Apoptosis; MAPK
	Flavokawain A (Flavokavain A) 是 kava 提取物中的查耳酮，是一种抗癌试剂，具有抗肿瘤活性。它通过 Bax 蛋白依赖和线粒体依赖的凋亡途径诱导细胞凋亡，有潜力用于膀胱癌的相关研究。
T6S1699	Shogaol [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol	Lipoxygenase; Autophagy	Autophagy; Metabolism
	6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物，具有抗癌、抗炎和抗氧化的多种生物活性。
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
T40988	(+)-Norlirioferine	Others	Others
	(+)-Norlirioferine is an alkaloid compound that exhibits cell growth inhibitory effects on macrophages and VERO cells.
TN4603	Myricanol	BCL; VEGFR; Caspase; HIF	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.
TN3113	5-Heptadecylresorcinol 芒果	Others	Others
	5-Heptadecylresorcinol has strong inhibitory property against the growth of PC3 cells.
T2S0606	Bakkenolide A	IL Receptor; IκB/IKK; GSK-3; TNF; Akt; Caspase; PI3K; HDAC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways.
TN3837	Desmethoxycentaureidin	Others	Others
	Desmethoxycentaureidin shows high inhibitory activity against HeLa cell growth (GI50 9 microM).
T72805	(±)-Hydnocarpin	Others	Others
	(±)-Hydnocarpin 是一种黄酮木脂素。(±)-Hydnocarpin 可以抑制S. aureus 的生长，MIC50值为 3.1 μM。
TN3280	8-Hydroxy-4-cadinen-3-one	Others	Others
	8-Hydroxy-4-cadinen-3-one shows significant inhibitory activity against A.thaliana seedling root growth.
TN3563	Caesalmin B	Antifection	Microbiology/Virology
	Caesalmin B shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.
TN3902	Durantoside I	Others	Others
	Durantoside I has inhibitory activity on the growth of lettuce seedling. It also displays DPPH scavenging activity.
T40440	Isobyakangelicol Isobyakangelicol,Anhydrobyakangelicin	Others	Others
	Isobyakangelicol, a coumarin compound present in Angelica dahurica roots, exhibits inhibitory effects on the growth of HeLa and HepG2 cells, with IC50 values of 70.04 μM and 17.97 μM, respectively.
T40866	8-Methylsulfinyloctyl isothiocyanate	Others	Others
	8-Methylsulfinyloctyl isothiocyanate is a compound with antimicrobial activity and notable inhibitory effects on plant growth. It also exhibits COX-2-mediated inflammatory response impairment in LPS-stimulated raw macrophages.
T4366	Quinovic acid	NF-κB; Caspase	Apoptosis; NF-κB; Proteases/Proteasome
	Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by inducing apoptosis through modulation of NF-ÎºB.
TN2837	29-Nor-20-oxolupeol	Others	Others
	29-Nor-20-oxolupeol(3 beta-Hydroxy-30-norlupan-20-one) has growth inhibitory effects on HL-60 cells.
TN3711	Corylifol C	ERK; EGFR; p38 MAPK; MEK	Angiogenesis; JAK/STAT signaling; MAPK; Tyrosine Kinase/Adaptors
	Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor (EGFR): 1.1 and 4.4 × 10(-6) μg/ml, respectively).
TN4743	Paucinervin A	Others	Others
	Paucinervin A has inhibitory effect against HeLa cell growth, with the IC50 value of 29.5 microM.
T83246	7-Deoxynarciclasine
	7-Deoxynarciclasine，一种可从Hymenocallis littoralis中提取的化合物，具有抑制癌细胞生长的作用。
T28379	PF-1163B PF1163B,(-)-PF1163B,PF 1163B	Others	Others
	PF-1163B is an antifungal agent form Penicillium sp. II. PF-1163B inhibits ergosterol (ERG) synthesis with IC50 value of 34 ng/ml. PF-1163B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotox
TN2747	2-Acetoxy-3-deacetoxycaesaldekarin E	Antifection	Microbiology/Virology
	2-Acetoxy-3-deacetoxycaesaldekarin E shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.
TN2219	Sophoraisoflavone A 鲁冰花,砂生槐异黄酮 A	MRP; Antifection	Immunology/Inflammation; Microbiology/Virology
	Sophoraisoflavone A is a potential MRP inhibitor; it is also an inhibitor of germ tube growth in the AM fungus Gigaspora margarita, it strongly inhibited germ tube growth at 1.25 ug/disc. Sophoraisoflavone A shows inhibitory effects on copper-induced prot
TN2515	1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one	Antifection	Microbiology/Virology
	(4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one shows growth inhibitory activity in vitro versus bloodstream forms of African trypanosomes, with the IC(50) value in the range of 1-3 microg/mL.
TN7414	10-Deacetylcephalomannine	Others	Others
	10-Deacetylcephalomannin exhibits activity against PS leukemia in vivo; however, its instability leads to an equilibrium mixture with its cytotoxic C-7 epimer. Additionally, 10-Deacetylcephalomannine demonstrates growth inhibitory effects on human cancer cell lines, including cervical HeLa adenocarcinoma.
TN2504	1,5-Dihydroxyxanthone	EGFR; AChR	Angiogenesis; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors
	1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have anticholinesterase activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzym
TN4443	Lipiferolide	Telomerase; Antifection	DNA Damage/DNA Repair; Microbiology/Virology
	Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells, it possesses cytotoxic activity against KB cells. Liriodenine also has antiplasmodial activity.
TN4132	Germanicol
	Germanicol induces selective growth inhibitory effects in human colon HCT-116 and HT29 cancer cells through induction of apoptosis, cell cycle arrest and inhibition of cell migration. Germanicol may have anti-inflammatory effects .
TN4387	Khellactone	Antifection	Microbiology/Virology
	Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -sensitive strains of with IC(50) values from 1.5 and 2.4 microM.
TN3318	9-Hydroxy-alpha-lapachone	Antifection	Microbiology/Virology
	9-Hydroxy-alpha-lapachone can highly inhibit the growth of H. pylori, it exhibits potent inhibitory activity against H. pylori Cystathionine gamma-synthase, with IC(50) values of 4.64 microM. It may have anti-inflammatory activity, it exhibits potent inhi
TN5061	Stephanine	Adrenergic Receptor; Antifection	GPCR/G Protein; Microbiology/Virology; Neuroscience
	l-Stephanine is a potent and highly selective alpha 1 adrenoceptor blocker, inhibits anococcygeus muscle contraction induced by phenylephrine with pA2 values of 6.76. Stephanine shows significant antiplasmodial activities with IC(50) ranged from 1.2 uM to 52.3 uM. Stephanine and crebanine have high inhibitory activity against gram-positive animal pathogenic bacteria, with MIC values of 0.078-0.312g/l, but low inhibitory activity against gram-negative animal pathogenic bacteria, they also inhibit...
T79995	(+)-Epieudesmin	Others	Others
	(+)-Epieudesmin，一种具抗肿瘤特性的化合物，对癌细胞系展现轻微抑制作用，亦能抑制革兰氏阴性病原菌生长。
TN4308	Isolupalbigenin	Antifection	Microbiology/Virology
	Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also shows in vitro inhibitory activity toward human glyoxalase I. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection.
TN4174	Guajadial	Glucokinase	Metabolism
	Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Receptors Modulators (SERMs), therefore holding significant potential for anticancer therapy, it ex
TN3973	Epinodosin	Others	Others
	Epinodosin induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner.Epinodosin has a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in Lactuca sativa L. seedlings.
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天然产物

Cat.No: TN1402

Synonym: 阿江榄仁素,2ALPHA,19ALPHA,23-三羟基齐墩果酸

Target: Antifection, Immunology/Inflammation related

Cat.No: TN1028

Target: Others

Coptisine sulfate

Cat.No: T4S0051

Target: Indoleamine 2,3-Dioxygenase (IDO)

Demethylwedelolactone

Cat.No: T5S0689

Synonym: 去甲蟛蜞菊内酯,去甲基蟛蜞内酯

Target: Serine Protease

Cat.No: TN1433

Target: FAK, Others, Akt

Cat.No: TN2347

Synonym: 麻醉椒苦素,Methysticin

Target: Others

Cat.No: T2979

Synonym: DL-薄荷醇,Hexahydrothymol,(±)-Menthol,薄荷醇

Target: GABA Receptor, AChE

Cat.No: T2978

Target: AMPK

Cat.No: TN1905

Synonym: 七叶苷甲基醚,6-甲氧基香豆素-7-0-BETA-D-吡喃葡萄糖苷

Target: Antifection

Cat.No: T4S0998

Synonym: 红车轴草根甙/三叶豆紫檀苷,三叶豆紫檀苷

Target: TNF, Tyrosinase

Cat.No: T7028

Synonym: LICOCHALCONEC,甘草查尔酮C

Target: Phosphatase, Antioxidant, Glucosidase

Cat.No: T3864

Target: BCL, Antibacterial

Cat.No: T3S2312

Synonym: 枸橘苷,Isosakuranetin-7-neohesperidoside

Target: Apoptosis, Others

Cat.No: T3923

Synonym: Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮

Target: Apoptosis, Tyrosinase

Cat.No: T2S1865

Synonym: Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯

Target: Antioxidant, Influenza Virus, Reactive Oxygen Species, Antibacterial, Antifungal, HSV

Cat.No: TL0008

Target: Wnt/beta-catenin, Glucosidase

Cat.No: T3S0737

Synonym: 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A

Target: Apoptosis, p38 MAPK

Cat.No: T6S1699

Synonym: [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol

Target: Lipoxygenase, Autophagy

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

(+)-Norlirioferine

Cat.No: T40988

Target: Others

Cat.No: TN4603

Target: BCL, VEGFR, Caspase, HIF

5-Heptadecylresorcinol

Cat.No: TN3113

Synonym: 芒果

Target: Others

Cat.No: T2S0606

Target: IL Receptor, IκB/IKK, GSK-3, TNF, Akt, Caspase, PI3K, HDAC

Desmethoxycentaureidin

Cat.No: TN3837

Target: Others

(±)-Hydnocarpin

Cat.No: T72805

Target: Others

8-Hydroxy-4-cadinen-3-one

Cat.No: TN3280

Target: Others

Cat.No: TN3563

Target: Antifection

Cat.No: TN3902

Target: Others

Isobyakangelicol

Cat.No: T40440

Synonym: Isobyakangelicol,Anhydrobyakangelicin

Target: Others

8-Methylsulfinyloctyl isothiocyanate

Cat.No: T40866

Target: Others

Cat.No: T4366

Target: NF-κB, Caspase

29-Nor-20-oxolupeol

Cat.No: TN2837

Target: Others

Cat.No: TN3711

Target: ERK, EGFR, p38 MAPK, MEK

Cat.No: TN4743

Target: Others

7-Deoxynarciclasine

Cat.No: T83246

Cat.No: T28379

Synonym: PF1163B,(-)-PF1163B,PF 1163B

Target: Others

2-Acetoxy-3-deacetoxycaesaldekarin E

Cat.No: TN2747

Target: Antifection

Sophoraisoflavone A

Cat.No: TN2219

Synonym: 鲁冰花,砂生槐异黄酮 A

Target: MRP, Antifection

1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one

Cat.No: TN2515

Target: Antifection

10-Deacetylcephalomannine

Cat.No: TN7414

Target: Others

1,5-Dihydroxyxanthone

Cat.No: TN2504

Target: EGFR, AChR

Cat.No: TN4443

Target: Telomerase, Antifection

Cat.No: TN4132

Cat.No: TN4387

Target: Antifection

9-Hydroxy-alpha-lapachone

Cat.No: TN3318

Target: Antifection

Cat.No: TN5061

Target: Adrenergic Receptor, Antifection

(+)-Epieudesmin

Cat.No: T79995

Target: Others

Isolupalbigenin

Cat.No: TN4308

Target: Antifection

Cat.No: TN4174

Target: Glucokinase

Cat.No: TN3973

Target: Others

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01137	MIA Protein, Human, Recombinant (His) MIA,Melanoma Inhibitory Activity Protein,Melanoma-D...	Human	E. coli
	Melanoma Inhibitory Activity Protein (MIA) is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells, which was the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family: MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an au...
TMPH-01669	Metallothionein-3/MT3 Protein, Human, Recombinant (His & SUMO) Metallothionein-III,Metallothionein-3,GIFB,MT3,Growth	Human	E. coli
	Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.
TMPJ-01414	GDF-15 Protein, Mouse, Recombinant (His & Flag) Growth Differentiation Factor 15, Macrophage in...	Mouse	HEK293 Cells
	Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be secreted by a wide variety of cell types in response to a broad range of stressors. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. GDF15 was shown to inhibit proliferation of primitive hematopoietic progenito...
TMPJ-01467	Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His) Oncostatin-M,OSM	Human	E. coli
	Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, which Inhibits the proliferation of a number of tumor cell lines. It stimulates proliferation of AIDS-KS cells. OSM regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is considered as a pleiotropic cytokine that initiates its biological ac...
TMPH-01016	GDF10 Protein, Human, Recombinant (His) Bone-inducing protein,Bone morphogenetic protein 3B,GDF10,	Human	E. coli
	Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis. GDF-10 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 16.1 kDa and the accession number is P55107.
TMPJ-00517	WIF-1 Protein, Human, Recombinant (His) Wnt Inhibitory Factor 1,WIF-1,WIF1	Human	HEK293 Cells
	Wnt Inhibitory Factor 1 (WIF1) is a secreted protein, which binds WNT proteins and inhibits their activities. WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. is found to be present in fish, amphibia and mammals. WIF1 is a recurrent target in human salivary gland oncogenesis.WIF1 may be involved in mesoderm segmentation. WIF1 is a tumor suppress...
TMPH-01875	Plexin-B1 Protein, Human, Recombinant (His) Semaphorin receptor SEP,PLXNB1,Plexin-B1	Human	E. coli
	Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Plexin-B1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 56.4 kDa and the accession number is O43157.
TMPH-01876	Plexin-B1 Protein, Human, Recombinant (mFc) Plexin-B1,Semaphorin receptor SEP,PLXNB1	Human	HEK293 Cells
	Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Plexin-B1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predicted molecular weight is 83.2 kDa and the accession number is O43157.
TMPH-01702	SMAD6 Protein, Human, Recombinant (E. coli, His & Myc) SMAD6,Mothers against decapentaplegic homolog 6,SMAD family ...	Human	E. coli
	Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta. Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory gen...
TMPY-02264	LRIG1 Protein, Mouse, Recombinant (His) LIG-1,D6Bwg0781e,leucine-rich repeats and immunoglobulin-lik...	Mouse	HEK293 Cells
	Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a tumor suppressor and a negative regulator of several receptor tyrosine kinases. Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit the growth of different types of malignancies. Leucine-rich repeats and immunoglobulin-like domains 1(LRIG1)is a kind of transmembrane glycoprotein, which is induce...
TMPH-02866	RBBP9 Protein, Mouse, Recombinant (His) Retinoblastoma-binding protein 9,Putative hydrolase RBBP9,B5...	Mouse	P. pastoris (Yeast)
	Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. RBBP9 Protein, Mouse, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 22.4 kDa and t...
TMPY-03989	PFDN1 Protein, Human, Recombinant (His) PDF,PFD1,prefoldin subunit 1	Human	E. coli
	PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1 was involved in the progression of CRC, and provide new insights into PFDN1 as a potential therapeutic target for colorectal cancer (CRC) treatment. PFDN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is ...
TMPY-02046	PFDN1 Protein, Mouse, Recombinant (His) AU044714,AA408327,2700086I23Rik,prefoldin subunit 1	Mouse	E. coli
	PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1 was involved in the progression of CRC, and provide new insights into PFDN1 as a potential therapeutic target for colorectal cancer (CRC) treatment. PFDN1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is ...
TMPY-02849	WIF1 Protein, Mouse, Recombinant (His) AW107799,WIF-1,WNT inhibitory factor 1	Mouse	HEK293 Cells
	WIF1, also known as WIF-1 and wnt inhibitory factor 1, is a secreted protein that binds WNT proteins and inhibits their activities. It contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 may be involved in mesoderm segmentation and can be detected in fish, amphibia and mammals. WIF-1 is a recurrent target in human salivary gland oncogenesis. Downre...
TMPY-00186	GHRH Protein, Human, Recombinant (hFc) GRF,INN,growth hormone releasing hormone,GHRF	Human	HEK293 Cells
	The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in infertility. Growth hormone releasing hormone (GHRH) has recently been shown to increase the level of gamma-aminobutyric acid (GABA) and activate GABA receptors (GABARs) in the cerebral cortex. GABA is an inhibitory neurotransmitter that can inhibit seizures. GHRH may pl...
TMPY-00950	WISP1/CCN4 Protein, Human, Recombinant (His) WISP1c,WISP1i,CCN4,WNT1 inducible signaling pathway protein ...	Human	HEK293 Cells
	CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: an IGFBP (insulin-like growth factor-binding) domain, a ...
TMPJ-00271	SMAD3 Protein, Human, Recombinant (His & Flag) SMAD 3,Mothers against DPP homolog 3,hMAD-3,MADH3,JV15-2,SMA...	Human	E. coli
	Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated...
TMPY-04399	TAOK3 Protein, Human, Recombinant (aa 1-411, His & GST) DPK,MAP3K18,TAO kinase 3,JIK	Human	Baculovirus Insect Cells
	Serine/threonine-protein kinase TAO3, also known as cutaneous T-cell lymphoma-associated antigen HD-CL-9, CTCL-associated antigen HD-CL-9, Dendritic cell-derived protein kinase, JNK / SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, Thousand and one amino acid protein 3, JIK, TAOK3 and MAP3K18, is cytoplasm and peripheral membrane protein which belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. Protein kinases are ...
TMPJ-00490	Serpin A5 Protein, Human, Recombinant (His) Plasminogen Activator Inhibitor 3,Acrosomal Serine Protease ...	Human	HEK293 Cells
	Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes o...
TMPJ-01158	ALK-2/ACVR1 Protein, Human, Recombinant (hFc) ACVRLK2,FOP,Activin RIA,ACTRI,ALK-2,activin A receptor, type...	Human	HEK293 Cells
	Activin RIA, also known as ALK-2, TSK-7L, SKR1, TSR-I, and ACTR-I, is a glycosylated 65 kDa type I receptor in the TGF-beta serine/threonine kinase receptor family. Binding of TGF-beta superfamily ligands induces formation of a heterotetrameric complex that contains two chains each of a type I and a type II receptor in multiple combinations. The type II receptors phosphorylate the type I receptors which then phosphorylate and activate Smad signal transduction proteins. Activin RIA functions in a...

重组蛋白

MIA Protein, Human, Recombinant (His)

Cat.No: TMPJ-01137

Species: Human

Expression System: E. coli

Metallothionein-3/MT3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01669

Species: Human

Expression System: E. coli

GDF-15 Protein, Mouse, Recombinant (His & Flag)

Cat.No: TMPJ-01414

Species: Mouse

Expression System: HEK293 Cells

Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPJ-01467

Species: Human

Expression System: E. coli

GDF10 Protein, Human, Recombinant (His)

Cat.No: TMPH-01016

Species: Human

Expression System: E. coli

WIF-1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00517

Species: Human

Expression System: HEK293 Cells

Plexin-B1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01875

Species: Human

Expression System: E. coli

Plexin-B1 Protein, Human, Recombinant (mFc)

Cat.No: TMPH-01876

Species: Human

Expression System: HEK293 Cells

SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-01702

Species: Human

Expression System: E. coli

LRIG1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02264

Species: Mouse

Expression System: HEK293 Cells

RBBP9 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02866

Species: Mouse

Expression System: P. pastoris (Yeast)

PFDN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03989

Species: Human

Expression System: E. coli

PFDN1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02046

Species: Mouse

Expression System: E. coli

WIF1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02849

Species: Mouse

Expression System: HEK293 Cells

GHRH Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00186

Species: Human

Expression System: HEK293 Cells

WISP1/CCN4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00950

Species: Human

Expression System: HEK293 Cells

SMAD3 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPJ-00271

Species: Human

Expression System: E. coli

TAOK3 Protein, Human, Recombinant (aa 1-411, His & GST)

Cat.No: TMPY-04399

Species: Human

Expression System: Baculovirus Insect Cells

Serpin A5 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00490

Species: Human

Expression System: HEK293 Cells

ALK-2/ACVR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-01158

Species: Human

Expression System: HEK293 Cells

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