163
14
150
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8680 |
FIBROBLAST GROWTH FACTOR, BASIC, HUMAN
|
||
FIBROBLAST GROWTH FACTOR, BASIC, HUMAN 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T8680,CAS号为 62031-54-3。 | |||
T37819 |
Brain-Derived Acidic Fibroblast Growth Factor (102-111) (bovine) (trifluoroacetate salt)
|
||
Brain-derived acidic fibroblast growth factor (102-111) is a peptide fragment of brain-derived acidic fibroblast growth factor (aFGF). aFGF is an angiogenic vascular endothelial cell mitogen produced in bovine brain that has sequence homology to interleukin-1. It also shares sequence homology with the known neuropeptides neuromedin C , bombesin , neuromedin K , substance K , substance P , physalaemin, and eledoisin. aFGF (102-111) corresponds to amino acid residues 102-111 of the fulllength pept... | |||
T37595 |
Brain-Derived Acidic Fibroblast Growth Factor (1-11) (bovine) (trifluoroacetate salt)
|
||
Brain-derived acidic fibroblast growth factor (brain-derived aFGF) (1-11) is a peptide fragment of brain-derived aFGF. Brain-derived aFGF is an angiogenic vascular endothelial cell mitogen produced in bovine brain that has sequence homology to interleukin-1. aFGF (1-11) corresponds to amino acid residues 1-11 of the full length peptide. | |||
T37820 |
Brain-Derived Basic Fibroblast Growth Factor (1-24) (bovine) (trifluoroacetate salt)
|
||
Brain-derived basic fibroblast growth factor (1-24) (brain-derived bFGF) is a peptide fragment of brain-derived bFGF. bFGF is a peptide produced in bovine brain that is protective in a rat model of pressure-induced retinal ischemia. bFGF (1-24) corresponds to amino acid residues 1-24 of the full length peptide. | |||
T76321 |
Brain Derived Basic Fibroblast Growth Factor (1-24)
|
||
Brain Derived BasicFibroblast Growth Factor(1-24) (FGF basic 1-24) 是一种合成肽,表现出抗细菌和抗HBV 的活性。Brain Derived BasicFibroblast Growth Factor(1-24) 可用于感染性疾病和免疫性疾病的研究。 | |||
T9030 |
SU4984
|
FGFR; IGF-1R; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SU4984 是蛋白质酪氨酸激酶抑制剂,能够抑制成纤维细胞生长因子受体 1 (FGFR1) (IC50:10-20 μM),还能够抑制血小板衍生的生长因子受体和胰岛素受体的活性。它可用于研究癌症。 | |||
T6082 |
SSR128129E
SSR |
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SSR128129E (SSR) 是一种变构和口服活性 FGFR1 抑制剂 (IC50:1.9 μM),但不影响其他相关的 RTK。 | |||
T1948 |
AZD4547
|
VEGFR; FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
AZD4547 是FGFR 家族抑制剂,能够作用于FGFR1 (IC50:0.2 nM),FGFR2 (IC50:2.5 nM),FGFR3 (IC50:1.8 nM) 和FGFR4 (IC50:165 nM)。 | |||
T6836 |
FIIN-2
|
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
FIIN2 是一种 FGFR 的不可逆抑制剂,能够抑制 FGFR1 (IC50:3.1 nM),FGFR2 (IC50:4.3 nM),FGFR3 (IC50:27 nM) 和 FGFR4 (IC50:45 nM)。 | |||
T2347 |
BLU9931
|
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
BLU9931 是高度选择性的,不可逆的成纤维细胞生长因子受体 4 抑制剂,其 IC50=3 nM,Kd=6 nM,具有抗肿瘤作用。 | |||
T9008 |
NPD8733
|
Others | Others |
NPD8733 是癌细胞增强的成纤维细胞迁移抑制剂。它是与多种细胞活动 (AAA+) 蛋白家族相关的 ATP 酶的成员,能够与含 valosin 的蛋白 (VCP)/p97特异性结合,对癌症疾病具有潜在的研究价值。 | |||
TQ0256 |
FGFR4-IN-1
|
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
FGFR4-IN-1 是一种 FGFR4 抑制剂 (IC50:0.7 nM)。 | |||
T3492 |
PD-166866
PD166866 |
FGFR; Autophagy | Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors |
PD-166866是一种选择性FGFR1酪氨酸激酶抑制剂,IC50值为52.4 nM。 | |||
T16781 |
Rogaratinib
BAY1163877 |
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Rogaratinib (BAY1163877) 选择性抑制成纤维细胞生长因子受体。 | |||
T3274 |
S49076
|
FGFR; c-Met/HGFR; TAM Receptor | Angiogenesis; Tyrosine Kinase/Adaptors |
S49076 是一种新型 MET、AXL/MER 和 FGFR1/2/3 高效抑制剂,IC50<20 nM。 | |||
T38155 |
N-Acetyl-D-cysteine
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
N-Acetyl-D-cysteine 具有抗氧化活性,机制是通过与巯基反应清除ROS。N-Acetyl-D-cysteine 不能进入谷胱甘肽代谢途径。 | |||
T3714 |
SUN11602
SUN 11602 |
ERK; FGFR | Angiogenesis; MAPK; Tyrosine Kinase/Adaptors |
SUN11602 是新型的碱性苯胺化合物,具有成纤维细胞生长因子特性。 | |||
T2361 |
LY2874455
LY 2874455,LY-2874455 |
VEGFR; FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
LY2874455 是pan-FGFR 抑制剂,能够抑制FGFR1 (IC50:2.8 nM),FGFR2 (IC50:2.6 nM),FGFR3 (IC50:6.4 nM),FGFR4 (IC50:6 nM)。 | |||
T5122 |
Alofanib
RPT835 |
Apoptosis; FGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Alofanib (RPT835) 是一种高效和选择性的成纤维细胞生长因子受体2的变构抑制剂,具有抗癌和抗血管生成活性。 | |||
TQ0228 |
Derazantinib
ARQ-087 |
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Derazantinib (ARQ-087) 是一种有效的,ATP 竞争型的,具有口服活性的酪氨酸激酶抑制剂,能够抑制软骨细胞FGFR1 (IC50:4.5 nM)、FGFR2 (IC50:1.8 nM)、FGFR3 (IC50:4.35nM)。 | |||
T5473 |
ASP5878
ASP-5878 |
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
ASP5878 是一种 FGFR 1 (IC50:0.47 nM)、FGFR 2 (IC50:0.6 nM)、FGFR 3 (IC50:0.74 nM)、和 FGFR 4 (IC50:3.5 nM)的抑制剂,具有口服活性,具有潜在的抗肿瘤作用。 | |||
T12401 |
Pemigatinib
INCB054828 |
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Pemigatinib (INCB054828) 是一种口服具有活力的,选择性的 FGFR 抑制剂,能够作用于 FGFR1 (IC50:0.4 nM),FGFR2 (IC50:0.5 nM),FGFR3 (IC50:1.2 nM),FGFR4 (IC50:30 nM),有用于胆管癌的潜力。 | |||
T3456 |
Fisogatinib
BLU554,BLU 554,BLU-554 |
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Fisogatinib (BLU-554) 是高效的、选择性的、口服具有活力的 FGFR4 抑制剂(IC50:5 nM)。它在依赖FGFR4信号传导的肝细胞癌模型中具有显著的抗肿瘤活性。 | |||
T2642 |
PD173074
|
Apoptosis; EGFR; VEGFR; FGFR; IGF-1R; Src | Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
PD173074 是一种 FGFR1抑制剂,IC50为 25 nM。它也可抑制 VEGFR2活性,IC50值为 100-200 nM。 | |||
T5170 |
KHS101 hydrochloride
盐酸KHS101 |
FGFR; Microtubule Associated | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
KHS101 hydrochloride 能够选择性的诱导神经元分化表型,能够与转化酸性含螺旋蛋白发生相互作用。 | |||
T3466 |
FIIN-3
|
EGFR; FGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
FIIN-3 是FGFR 的不可逆抑制剂,对FGFR1、FGFR2、FGFR3和FGFR4的IC50值分别为13.1、21、31.4和35.3 nM。 | |||
T16686 |
Pyr10
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
Pyr10 是吡唑衍生物,是TRPC3通道的选择性抑制剂。Pyr10抑制卡巴可刺激的TRPC3转染的 HEK293 细胞中的 Ca2+流入。它具有区分受体操纵的TRPC3和天然基质相互作用分子 1 (STIM1)/Orai1 通道的能力。 | |||
T3726 |
Erdafitinib
厄达替尼,JNJ-42756493 |
Apoptosis; FGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Erdafitinib (JNJ-42756493) 是一种广谱的 FGFR 抑制剂,可以抑制 FGFR1/2/3/4 (IC50=1.2/2.5/3.0/5.7 nM)。Erdafitinib 具有抗肿瘤活性,可以诱导细胞凋亡。 | |||
T9149 |
2BAct
2B-Act,2B Act |
PERK | Apoptosis |
2BAct 是一种具有口服活性的高选择性真核起始因子eIF2B 活化剂,EC50为 33 nM。它可防止由慢性综合应激反应引起的神经系统缺陷。 | |||
T24477 |
MK6-83
MK683 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
MK6-83 是有效的TRPML1的候选激动剂,具有优越的活性。它在IV 型粘脂病中具有研究的价值。 | |||
T4235 |
Roblitinib
FGF-401 |
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Roblitinib (FGF-401) 是一种口服有效的,高选择性的FGFR4抑制剂(IC50:1.9 nM),具有抗癌作用。 | |||
T5044 |
Futibatinib
TAS120,FGFR-IN-1 |
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Futibatinib (FGFR-IN-1) 是口服具有活力的、选择性强的、高生物利用度的、不可逆的 FGFR 抑制剂。它抑制突变型和野生型 FGFR2,且 IC50相似(wild-type FGFR2=0.9 nM; V5651=1-3 nM; N550H=3.6 nM; E566G=2.4 nM)。 | |||
T4425 |
JK-P3
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
JK-P3 是广谱 VEGFR2抑制剂。它能够抑制 VEGF-A 刺激的 VEGFR2 激活和细胞内信号转导,也可阻碍内皮单层细胞迁移和血管生成,影响成纤维细胞生长因子受体激酶在体外的活性。它具有抗血管生成的作用。 | |||
T6996 |
SU 5402
SU5402 |
VEGFR; FGFR; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SU 5402 是多靶点受体酪氨酸激酶抑制剂,能够抑制VEGFR2 (IC50:20 nM),FGFR1 (IC50:30 nM),PDGFRβ (IC50:510 nM)。 | |||
T7611 |
ODM-203
|
VEGFR; FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
ODM-203 是 FGFR 和 VEGFR 家族的抑制剂,具有显著的抗肿瘤活性,能够诱导抗肿瘤免疫。 | |||
T15185 |
Lucitanib
E-3810,德立替尼 |
VEGFR; FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Lucitanib (E-3810) 是 VEGFR 和 FGFR 的双重抑制剂,有效和选择性地抑制VEGFR1 (IC50:7 nM),VEGFR2 (IC50:25 nM),VEGFR3 (IC50:10 nM),FGFR1 (IC50:17.5 nM),FGFR2 (IC50:82.5 nM)。 | |||
T5466 |
Tyrosine kinase-IN-1
|
VEGFR; FGFR; FLT; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Tyrosine kinase-IN-1是一种多靶点酪氨酸激酶抑制剂,能够抑制KDR (IC50:4 nM),Flt-1 (IC50:20 nM),FGFR1 (IC50:4 nM) 和 PDGFRα (IC50:2 nM)。 | |||
T11279 |
FGFR1/DDR2 inhibitor 1
|
Discoidin Domain Receptor (DDR); FGFR; Others | Angiogenesis; Others; Tyrosine Kinase/Adaptors |
FGFR1/DDR2 inhibitor 1 是一种具有口服活性的成纤维细胞生长因子受体 1 和盘状蛋白域受体 2 的抑制剂,能够抑制 FGFR1 (IC50:31.1 nM) 和 DDR2 (IC50:3.2 nM),具有抗肿瘤作用。 | |||
TQ0015 |
PRN1371
|
c-Fms; FGFR; CSF-1R | Angiogenesis; Tyrosine Kinase/Adaptors |
PRN1371 是一种高效的、选择性的FGFR1-4和CSF1R 抑制剂,对FGFR1,FGFR2,FGFR3,FGFR4 和 CSF1R 的IC50值分别为 0.6,1.3,4.1,19.3 和 8.1 nM。 | |||
TQ0317 |
R1530
R-1530,R 1530 |
VEGFR; FGFR; FLT; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
R1530 是一种多激酶抑制剂,具有抗肿瘤和抗血管生成活性。它是具有口服活性的有丝分裂/血管生成高效双重作用抑制剂, 抑制 VGFR2、FGFR1作用的 IC50分别为 10 nM 和 28 nM。 | |||
T1975 |
Infigratinib
BGJ-398,NVP-BGJ398 |
Apoptosis; FGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Infigratinib (NVP-BGJ398) 是一种 FGFR 家族抑制剂,抑制 FGFR1,FGFR2,FGFR3和 FGFR4的 IC50分别为 0.9 nM,1.4 nM,1 nM,60 nM。 | |||
T8492 |
BO-264
|
Apoptosis; FGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
BO-264 是一种有口服活性的转化酸性卷曲螺旋 3 抑制剂,可特异性阻断 FGFR3-TACC3融合蛋白的功能。它诱导纺锤体检查点依赖的有丝分裂阻滞,DNA 损伤和细胞凋亡,具有广谱抗肿瘤活性。 | |||
T4318 |
EOC317
ACTB-1003,ACTB1003,ACTB 1003 |
VEGFR; FGFR; Tie-2 | Angiogenesis; Tyrosine Kinase/Adaptors |
EOC317 (ACTB-1003) 是一种口服可用的激酶抑制剂,能够抑制 FGFR1 (IC50:6 nM),VEGFR2 (IC50:2 nM) 和 Tie-2 (IC50:4 nM)。 | |||
T2341 |
KW-2449
KW2449 |
Apoptosis; FGFR; FLT; JAK; Bcr-Abl; Src; c-Kit; Aurora Kinase | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
KW-2449是一种多靶点激酶抑制剂,对FLT3,ABL,ABLT315I 和极光激酶的IC50值分别为6.6,14,4 和 48 nM。 | |||
T6024 |
Zoligratinib
FF284,CH5183284,Debio 1347 |
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Zoligratinib (CH5183284) 是一种口服具有活力的,选择性的FGFR 抑制剂,能够抑制FGFR1 (IC50:9.3 nM),FGFR2 (IC50:7.6 nM),FGFR3 (IC50:22 nM),FGFR4 (IC50:290 nM)。 | |||
T2040 |
OAC1
BAS 00287861 |
OCT | Membrane transporter/Ion channel |
OAC1 (BAS 00287861) 是一种能够激活 Octamer 结合转录因子 4 的化合物。 它提高了 iPSC 重编程效率并加速重编程过程。 | |||
T0097L |
Pazopanib
帕唑帕尼,GW786034 |
VEGFR; FGFR; PDGFR; c-Kit; Autophagy | Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors |
Pazopanib (GW786034) 是一种小分子抑制剂,可抑制多种具有潜在抗肿瘤活性的蛋白酪氨酸激酶。它抑制VEGFR1、VEGFR2、VEGFR3、PDGFRβ、c-Kit、FGFR1和c-Fms 的IC50分别为10、30、47、84、74、140和146 nM。 | |||
T1777 |
Nintedanib
BIBF 1120,Intedanib,尼达尼布 |
VEGFR; FGFR; FLT; PDGFR; Src | Angiogenesis; Tyrosine Kinase/Adaptors |
Nintedanib (Intedanib) 是一种三重血管激酶抑制剂,抑制 VEGFR1、VEGFR2、VEGFR3 (IC50=34/13/13 nM),FGFR1、FGFR2、FGFR3 (IC50=69/37/108 nM),PDGFRα、PDGFRβ (IC50=59/65 nM)。Nintedanib 具有抗肿瘤活性,通过抑制血管生成来抑制肿瘤生长。 | |||
TP1158 |
Copper tripeptide
[N2-(N-甘氨酰-L-组氨酰)-L-赖氨酸]铜,GHK-Cu |
Others; Endogenous Metabolite | Metabolism; Others |
Copper tripeptide (GHK-Cu) 是天然存在的三肽,首先从人血浆中分离,但也能够在唾液和尿液中发现。它能够提高成纤维细胞中胶原蛋白,弹性蛋白,蛋白多糖和糖胺聚糖中信使 RNA 的产生。在伤口愈合期间,它能够通过蛋白水解从现有的细胞外蛋白质中除去,并且用作炎性和内皮细胞的化学引诱物。它是皮肤再生中多种细胞途径的天然调节剂。 | |||
T2638 |
Gandotinib
LY2784544 |
VEGFR; FGFR; FLT; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Gandotinib (LY2784544) 是一种JAK2抑制剂,IC50为 3 nM。它也抑制FLT3、FLT4、FGFR2、TYK2 和 TRKB,IC50分别为 4、25、32、44 和 95 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37512 |
cis-4-Hydroxy-L-proline
|
Endogenous Metabolite | Metabolism |
cis-4-Hydroxy-L-proline 是脯氨酸的一种类似物,抑制胶原蛋白的产生。它通过阻止三层螺旋胶原在细胞层上的沉积从而抑制成纤维细胞的生长。它还可抑制原发性N-亚硝基甲基脲诱导的大鼠乳腺肿瘤的生长。 | |||
T19355 |
Heparan Sulfate
硫酸乙酰肝素,硫酸类肝素 |
FGFR; Wnt/beta-catenin; Endogenous Metabolite | Angiogenesis; Cytoskeletal Signaling; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors |
Heparan sulfate 是一种复杂的线性多糖。Heparan sulfate 作为硫酸乙酰肝素蛋白聚糖的一部分出现,在细胞外基质和细胞表面表达丰富。 | |||
T2215 |
Ferulic Acid
Coniferic acid,Fumalic Acid,阿魏酸 |
FGFR; Endogenous Metabolite | Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors |
Ferulic Acid (Coniferic acid) 是新型的成纤维细胞生长因子受体 1 (FGFR1)抑制剂, 在FGFR1和FGFR2的IC50分别为 3.78 和 12.5 μM。 | |||
T0724 |
Formononetin
Biochanin B,Flavosil,刺芒柄花素,Formononetol |
Apoptosis; FGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Formononetin (Flavosil) 是一种 FGFR2抑制剂,IC50约为4.31 μM。 它是一种 O-甲基化的异黄酮,是来自黄芪根的植物雌激素,可有效抑制血管生成和肿瘤生长。 | |||
T8846 |
beta-Escin
B-escin,AESCINE,beta-七叶素 |
Immunology/Inflammation related | Immunology/Inflammation |
beta-Escin 是七叶树种子的主要活性成分。它可抑制碱性成纤维细胞生长因子所诱导的增殖、迁移、管形成以及体内 CAM 血管生成。它具有研究抗血管生成作用的分子机制的潜力。 | |||
T2857 |
2,5-Dihydroxybenzoic acid
龙胆酸,5-Hydroxysalicylic acid,Gentisic acid,Phloretate,Carboxyhydroquinone,Hydroquinonecarboxylic acid,Gentianic acid |
FGFR; Others; Endogenous Metabolite | Angiogenesis; Metabolism; Others; Tyrosine Kinase/Adaptors |
2,5-Dihydroxybenzoic acid (Gentisic acid) 是一种苯甲酸的代谢物,也是一种纤维母细胞生长因子(fibroblast growth factor)的强效抑制剂。 | |||
T2S0007 |
Ferulic acid sodium
阿魏酸钠,阿魏酸钠;3-甲氧基-4-羟基肉桂酸钠,Sodium ferulic,Ferulic acid sodium salt,Sodium ferulate |
FGFR; Reactive Oxygen Species; 5-HT Receptor; Endogenous Metabolite | Angiogenesis; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors |
Ferulic acid sodium (Sodium ferulic) 是新型的成纤维细胞生长因子受体 1 (FGFR1) 抑制剂。它对于FGFR1和FGFR2的IC50分别为 3.78 and 12.5 μM。 | |||
T3876 |
Loureirin B
龙血素B,龙血素 B |
PAI-1; ERK; Potassium Channel; JNK | MAPK; Membrane transporter/Ion channel; Metabolism |
Loureirin B 是从剑叶龙血树中分离到的一种黄酮,是 PAI-1抑制剂,IC50值为 26.10 μM。它抑制 KATP,以及 ERK 和 JNK 的磷酸化,具有抗糖尿病的功效。 | |||
T6943 |
Picropodophyllin
AXL1717,苦鬼臼脂素,Picropodophyllin (PPP),Picropodophyllotoxin,PPP,苦鬼臼毒素 |
Apoptosis; IGF-1R | Apoptosis; Tyrosine Kinase/Adaptors |
Picropodophyllin (Picropodophyllin (PPP)) 是一种选择性的胰岛素样生长因子-1受体抑制剂,IC50为1 nM。 | |||
T2787 |
Picroside I
6'-Cinnamoylcatalpol,胡黄连苦苷I |
MMP; STAT | JAK/STAT signaling; Proteases/Proteasome; Stem Cells |
Picroside I (6'-Cinnamoylcatalpol) 是胡黄连的一种天然产物,是有肝脏保护作用的代谢成分,可用于哮喘研究,有减轻炎症作用,还下调 pSTAT6 和 GATA3 表达。 | |||
T41245 |
Trimethylamine N-oxide
|
Reactive Oxygen Species; NOD-like Receptor (NLR); TGF-beta/Smad | Immunology/Inflammation; Metabolism; NF-κB; Stem Cells |
Trimethylamine N-oxide (TMAO) 是由胆碱、甜菜碱和肉碱通过肠道微生物代谢产生的一种无色氧化胺,积聚在海洋动物的组织中,可预防尿素对蛋白质的破坏作用。Trimethylamine N-oxide 通过激活 ROS/NLRP3 炎性体诱导炎症,可诱导纤维细胞的分化和心脏纤维化。 | |||
T3S0027 |
Picropodophyllotoxin
AXL 1717,Picropodophyllin,苦鬼臼毒素 |
IGF-1R | Tyrosine Kinase/Adaptors |
Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱,存在于五月树(Podophyllum peltatum) 中,是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达,而不干扰其他生长因子受体的活性,例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) )。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶,在多种癌细胞的生长和存活中起关键作用。 | |||
T40832 |
Ferulic acid acyl-β-D-glucoside
Ferulic acid glucoside,Ferulic acid acyl-β-D-glucoside |
Others | Others |
Ferulic acid acyl-β-D-glucoside, a metabolite of Ferulic Acid, is a novel inhibitor of fibroblast growth factor receptor 1 (FGFR1). It exhibits IC50 values of 3.78 µM and 12.5 µM for FGFR1 and FGFR2, respectively. | |||
TN5245 |
Vitexolide D
|
Antifection | Microbiology/Virology |
Vitexolide D shows moderate antibacterial activity against a panel of 46 Gram-positive strains. It also shows cytotoxic activities against the HCT-116 cancer cell line and human fetal lung fibroblast MRC5 cell line (1 < IC50s < 10 uM). |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04962 |
FAP Protein, Cynomolgus, Recombinant (His)
fibroblast activation protein, α,fibroblast |
Cynomolgus | HEK293 Cells |
FAP Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 87 kDa and the accession number is A0A2K5VGF4. | |||
TMPY-00117 |
FGF-16 Protein, Human, Cynomolgus, Recombinant
fibroblast growth factor 16 |
Human,Cynomolgus | Baculovirus Insect Cells |
Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of ... | |||
TMPY-04922 |
FAP Protein, Human, Recombinant (His), Biotinylated
DPPIV,Fibroblast Activation Protein alpha,DPPIVA,SI... |
Human | HEK293 Cells |
FAP Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 87.2 kDa and the accession number is Q12884-1. | |||
TMPY-02154 |
FAP Protein, Human, Recombinant (His)
fibroblast activation protein, alpha,Fibroblast... |
Human | HEK293 Cells |
FAP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 87.2 kDa and the accession number is Q12884-1. | |||
TMPY-01089 |
FGF-1 Protein, Mouse, Rat, Recombinant
fibroblast growth factor 1 (acidic) |
Mouse,Rat | E. coli |
FGF-1 Protein, Mouse, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16 kDa and the accession number is P61148. | |||
TMPY-01061 |
FGF-10 Protein, Human, Recombinant
fibroblast growth factor 10,KGF2 |
Human | E. coli |
Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 pla... | |||
TMPY-02907 |
FGF-19 Protein, Human, Recombinant
fibroblast growth factor 19,FGF19 |
Human | E. coli |
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglyca... | |||
TMPY-03467 |
IFN-beta Protein, Mouse, Recombinant
Ifb,IFN-β,interferon, beta 1, fibroblast,干扰素,IFNB,I... |
Mouse | HEK293 Cells |
IFN-beta Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 20.3 kDa and the accession number is P01575. | |||
TMPY-03145 |
IFN-beta Protein, Human, Recombinant
IFN-β,interferon, β1, fibroblast,IFNB,IFB,IFF,Inter... |
Human | CHO Cells |
IFN-beta Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 20 kDa and the accession number is P01574. | |||
TMPY-02626 |
FGF-18 Protein, Human, Recombinant (His)
FGF-18,ZFGF5,fibroblast growth factor 18 |
Human | HEK293 Cells |
FGF-18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.3 kDa and the accession number is O76093. | |||
TMPY-03382 |
FGF-6 Protein, Human, Recombinant
HBGF-6,HST2,fibroblast growth factor 6 |
Human | E. coli |
FGF6, also known as FGF-6, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis. It is also required for normal muscle regeneration. FGF6 gene d... | |||
TMPY-00831 |
IFN-beta Protein, Human, Recombinant (hFc)
IFNB,IFN-β,Interferon beta,interferon, beta 1, fibroblas... |
Human | HEK293 Cells |
IFN-beta Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.7 kDa and the accession number is A0A7R8GV38. | |||
TMPJ-00037 |
FGF-2 Protein, Mouse, Recombinant
Fibroblast Growth Factor 2,bFGF,HBGF-2,Basic Fi... |
Mouse | E. coli |
FGF basic is one of 22 mitogenic proteins of the FGF family, which show 35-60% amino acid conservation. Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. The 17 kDa mouse sequence has 98% aa identity with rat, and 95% identity with human, bovine, and sheep FGF basic. Binding of FGF to heparin or cell surface HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins, polysacchari... | |||
TMPY-00210 |
FGF-2 Protein, Mouse, Recombinant (His)
Fgfb,bFGF,Fgf-2,fibroblast growth factor 2 (basic) |
Mouse | E. coli |
FGF-2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.5 kDa and the accession number is P15655. | |||
TMPJ-00842 |
FGF-2 Protein, Rat, Recombinant
bFGF,Heparin-Binding Growth Factor 2,FGFB,Fibroblast |
Rat | E. coli |
FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. They act on several cell types to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects, and tissue repair. FGF-basic is a non-glycosylated heparin binding g... | |||
TMPY-02112 |
FGFR4 Protein, Human, Recombinant (His)
TKF,JTK2,CD334,fibroblast growth factor receptor 4 |
Human | HEK293 Cells |
FGFR4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22455-1. | |||
TMPY-03104 |
FGF-17 Protein, Human, Recombinant
fibroblast growth factor 17,HH20,FGF-13,FGF-17 |
Human | E. coli |
FGF-13, also known as FGF17, belongs to the fibroblast growth factor (FGF) family. Members of this family show broad mitogenic and cell survival activities, and play a role in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-13 is preferentially expressed in the embryonic brain. It interacts with FGFR3 and FGFR4. FGF-13 plays an important role in the regulation of embryonic development and as signaling mol... | |||
TMPY-04165 |
FGFR3 Protein, Human, Recombinant (His)
JTK4,CEK2,fibroblast growth factor receptor 3,HSFGF... |
Human | HEK293 Cells |
FGFR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.6 kDa and the accession number is P22607-1. | |||
TMPY-00749 |
FGF-2 Protein, Human, Recombinant
fibroblast growth factor 2 (basic),FGF-2,FGFB,HBGF-... |
Human | E. coli |
FGF-2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.5 kDa and the accession number is P09038-4. | |||
TMPY-02139 |
FGF-21 Protein, Mouse, Recombinant (His)
成纤维细胞生长因子,FGF-21,fibroblast growth factor 21 |
Mouse | HEK293 Cells |
FGF-21 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.3 kDa and the accession number is Q9JJN1. | |||
TMPY-06935 |
FGF-21 Protein, Human, Recombinant
成纤维细胞生长因子,UNQ3115 / PRO10196,fibroblast growth fact... |
Human | E. coli |
FGF-21 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.55 kDa and the accession number is NP_061986.1. | |||
TMPY-00403 |
FGF-7/KGF Protein, Human, Recombinant (His)
fibroblast growth factor 7,KGF,成纤维细胞生长因子,HBGF-7 |
Human | E. coli |
FGF-7/KGF Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 21 kDa and the accession number is P21781. | |||
TMPY-00341 |
FGFR3 Protein, Human, Recombinant (alpha IIIb, His)
CEK2,HSFGFR3EX,fibroblast growth factor receptor 3,... |
Human | HEK293 Cells |
FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2. | |||
TMPY-00804 |
FGF-9 Protein, Human, Recombinant (hFc)
SYNS3,FGF-9,fibroblast growth factor 9,HBGF-9,GAF,H... |
Human | HEK293 Cells |
FGF-9 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54 and 37 kDa and the accession number is A0A7U3L6D0. | |||
TMPY-05004 |
FGF-4 Protein, Human, Recombinant
HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,H... |
Human | E. coli |
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a... | |||
TMPY-06986 |
FGF-8b Protein, Human, Recombinant
NEWENTRY,fibroblast growth factor 8 (androgen-induc... |
Human | E. coli |
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac... | |||
TMPY-00005 |
FGF-8a Protein, Human, Recombinant
fibroblast growth factor 8 (androgen-induced),FGF-8... |
Human | E. coli |
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac... | |||
TMPJ-00090 |
FGF-9 Protein, Human, Recombinant
Fibroblast Growth Factor 9,Heparin-Binding Growth F... |
Human | E. coli |
Fibroblast Growth Factor 9 (FGF-9) belongs to the Fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In addition, FGF-9 may have a role in glial c... | |||
TMPJ-01011 |
FGF-9 Protein, Mouse, Recombinant (His)
heparin-binding growth factor-9,GAF,HBGF-9,Glia-activating f... |
Mouse | E. coli |
Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, v... | |||
TMPY-03357 |
FGFR2 Protein, Mouse, Recombinant (hFc)
KGFR,AU043015,KGFRTr,Bek,Fgfr7,svs,fibroblast growt... |
Mouse | HEK293 Cells |
FGFR2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is AAA39377.1. | |||
TMPY-00972 |
FGFR2 Protein, Human, Recombinant (His & hFc)
K-SAM,TK14,BBDS,fibroblast growth factor receptor 2... |
Human | HEK293 Cells |
FGFR2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 67.6 kDa and the accession number is P21802-1. | |||
TMPY-04085 |
FGF-9 Protein, Canine, Recombinant (mFc)
fibroblast growth factor 9 |
Canine | HEK293 Cells |
FGF-9 Protein, Canine, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 49.8 kDa and the accession number is A0A7U3L6D0. | |||
TMPY-03517 |
FGF-12 Protein, Canine, Recombinant
fibroblast growth factor 12 |
Canine | E. coli |
FGF12 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF12 lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. ... | |||
TMPY-06525 |
FAP Protein, Human, Recombinant (aa 27-760, His)
Fibroblast Activation Protein alpha,fibroblast<... |
Human | Baculovirus Insect Cells |
FAP Protein, Human, Recombinant (aa 27-760, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 86.31 kDa and the accession number is Q12884-1. | |||
TMPY-03828 |
IFN-beta Protein, Rhesus, Recombinant (mFc)
interferon, beta 1, fibroblast,干扰素,interferon, β1, ... |
Rhesus | HEK293 Cells |
IFN-beta Protein, Rhesus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46.4 kDa and the accession number is G7NFX1. | |||
TMPY-04033 |
FGF-14 Protein, Canine, Recombinant
fibroblast growth factor 14 |
Canine | E. coli |
FGF-14 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.1 kDa and the accession number is XP_003363267.1. | |||
TMPY-06915 |
FAP Protein, Human, Recombinant (His & Avi), Biotinylated
FAPA,Fapalpha,Fibroblast Activation Protein α,Fapα,... |
Human | HEK293 Cells |
FAP Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 88.23 kDa and the accession number is Q12884-1. | |||
TMPY-00423 |
FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc)
BFR-1,KGFR,TK25,JWS,ECT1,K-SAM,FGFR2 α(IIIb),CD332,fibro... |
Human | HEK293 Cells |
FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66.3 kDa and the accession number is P21802-17. | |||
TMPY-00756 |
FGF-1 Protein, Human, Recombinant
AFGF,ECGF-beta,ECGFB,fibroblast growth factor 1 (ac... |
Human | E. coli |
FGF-1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16 kDa and the accession number is P05230-1. | |||
TMPY-02862 |
FGFR4 Protein, Rat, Recombinant (His)
fibroblast growth factor receptor 4 |
Rat | HEK293 Cells |
FGFR4 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.3 kDa and the accession number is Q498D6. | |||
TMPY-03477 |
FGF-1 Protein, Cynomolgus, Recombinant
fibroblast growth factor 1 (acidic) |
Cynomolgus | E. coli |
FGF-1 Protein, Cynomolgus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16 kDa. | |||
TMPY-03322 |
FGFR4 Protein, Rhesus, Recombinant (hFc)
fibroblast growth factor receptor 4 |
Rhesus | HEK293 Cells |
FGFR4 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.6 kDa and the accession number is XP_001087243.1. | |||
TMPY-02853 |
FGFR3 Protein, Cynomolgus, Recombinant (hFc)
fibroblast growth factor receptor 3 |
Cynomolgus | HEK293 Cells |
FGFR3 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.1 kDa and the accession number is F7FZR9. | |||
TMPY-03683 |
FGFR4 Protein, Rhesus, Recombinant (His)
fibroblast growth factor receptor 4 |
Rhesus | HEK293 Cells |
FGFR4 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 61.8 kDa and the accession number is XP_001087243.1. | |||
TMPY-03926 |
FGFR1 Protein, Rhesus, Recombinant (His)
fibroblast growth factor receptor 1 |
Rhesus | HEK293 Cells |
FGFR1 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.6 kDa and the accession number is H9FRD4. | |||
TMPY-06034 |
FGFR1 Protein, Human, Recombinant (beta (IIIb), His)
FLG,CD331,N-SAM,HBGFR,HRTFDS,BFGFR,OGD,KAL2,fibroblast |
Human | HEK293 Cells |
FGFR1 Protein, Human, Recombinant (beta (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.8 kDa and the accession number is H9FRD4. | |||
TMPY-01011 |
FGFR1 Protein, Human, Recombinant (His)
KAL2,FLT2,FGFBR,HRTFDS,OGD,FLG,HBGFR,bFGF-R-1,CD331,fibr... |
Human | HEK293 Cells |
FGFR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is H9FRD4. | |||
TMPY-03622 |
FGF-1 Protein, Canine, Recombinant
fibroblast growth factor 1 (acidic) |
Canine | E. coli |
FGF-1 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16 kDa and the accession number is A0A8C0QGP1. | |||
TMPY-06036 |
FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)
FGFR-1,FLG,CD331,HH2,FLT2,KAL2,FGFBR,HBGFR,CEK,HRTFDS,fi... |
Human | HEK293 Cells |
FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7. | |||
TMPY-02635 |
FGFR4 Protein, Rat, Recombinant (hFc)
fibroblast growth factor receptor 4 |
Rat | HEK293 Cells |
FGFR4 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66 kDa and the accession number is Q498D6. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0298 |
Letermovir-d8
|
||
Letermovir-d8 是 Letermovir 的氘代化合物。Letermovir 的 CAS 号为 917389-32-3。Letermovir是一种新型抗 CMV 抑制剂,靶向病毒末端酶,抑制其活性。 |