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Search Results for " fatty liver "

Targets Recommended: COX Epoxide Hydrolase

64

抑制剂 & 化合物

17

天然产物

2

化合物库

15

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L1120	AMPK靶向分子库		80 compounds
	80 个靶向AMPK 的分子集合，可用于高通量和高内涵筛选；
L2540	肠道微生物代谢化合物库		614 compounds
	614 种肠道微生物代谢物的集合，可以用于高通量和高内涵筛选；

化合物库

AMPK靶向分子库

Cat.No: L1120

Compounds: 80

肠道微生物代谢化合物库

Cat.No: L2540

Compounds: 614

Cat. No.	Product Name	Target	Signaling Pathways
T12580	PTUPB	COX; Epoxide Hydrolase	Immunology/Inflammation; Metabolism; Neuroscience
	PTUPB 是强效的sEH(IC50:0.9 μM)和COX-2(IC50:1.26 μM)的双向抑制剂。
T2601	Vidofludimus SC12267,4sc-101	Dehydrogenase; DNA/RNA Synthesis; Interleukin	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism
	Vidofludimus (SC12267) 是一种新型的二氢乳清酸脱氢酶 (DHODH) 小分子抑制剂，可在不影响淋巴细胞增殖的条件下抑制IL-17的分泌。
T12883	Fezagepras PBI-4050,3-戊基苯乙酸,Setogepram	GPR	Endocrinology/Hormones; GPCR/G Protein
	Fezagepras (Setogepram) 是一种可口服的 GPR40激动剂和GPR84拮抗剂或反向激动剂。它减轻肾、肝和胰腺纤维化，具有抗纤维化、抗炎和抗增殖作用。
T6714	URB-597 KDS-4103,FAAH Inhibitor II	Mitophagy; FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	URB-597 (FAAH Inhibitor II) 是一种可口服的选择性FAAH 抑制剂。它抑制大鼠脑膜、体外大鼠神经元和人肝微粒体中的 FAAH 活性，IC50分别为 5、0.5和 3 nM。它具有抗抑郁样作用，可研究缓解疼痛。
T9010	IMM-H007	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	IMM-H007 是一种新型降脂剂，可增加 abca1 蛋白的表达。
T38715	MSDC-0602K MSDC-0602K,Azemiglitazone potassium	PPAR	DNA Damage/DNA Repair; Metabolism
	MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both ...
T9209	PF-05221304 STAT5 Inhibitor III,NSC 170984,R 6238,,Clesacostat	Acetyl-CoA Carboxylase	Metabolism
	PF-05221304 (NSC-170984) 是一种具有口服活性的肝脏靶向乙酰辅酶A 羧化酶 (ACC) 抑制剂，ACC 是脂肪酸合成的限速酶。
T37184	CX08005 2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid	Phosphatase	Metabolism
	CX08005 是一种蛋白酪氨酸磷酸酶 1B 抑制剂，可减轻与非酒精性脂肪肝相关的肝脏脂质蓄积和微循环障碍。
T63016	Nrf2 activator-4	Reactive Oxygen Species; Nrf2	Immunology/Inflammation; Metabolism; NF-κB
	Nrf2 activator-4 是一种具有口服活性的 Nrf2 激活剂（EC50: 0.63 μM），对小神经胶质细胞中活性氧的产生有抑制作用，用于治疗人类代谢功能障碍相关的脂肪肝病。
T12408	Perhexiline maleate	Others; Mitochondrial Metabolism	Metabolism; Others
	Perhexiline maleate 是一种口服活性的 CPT1和 CPT2抑制剂，可降低脂肪酸的代谢。Perhexiline maleate 对大鼠心脏和肝脏CPT 1的IC50值分别为77 和 148 μM。
T26165	Rubratoxin B	Others	Others
	Rubratoxin B is a mycotoxin that causes hypoglycemia and fatty liver and has exhibited anticancer activity.
T68370	Sdz 51641	Others	Others
	Sdz 51641 is an inhibitor of fatty acid oxidation which is highly selective for the liver.
T40302	FXR/TGR5 agonist 1	Others	Others
	FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease.
T85253	12,15-epoxy-13-methyl-12,14-Eicosadienoic Acid Furan Fatty Acid F5	Others	Others
	12,15-Epoxy-13-methyl-12,14-eicosadienoic acid, a furan fatty acid first identified in northern pike (E. lucius), exhibits elevated levels in the liver of starving cod.
T35801	ML-262	Others	Others
	ML-262 is an inhibitor of hepatic lipid droplet formation (IC50 = 6.4 nM in murine AML-12 cells), which is associated with non-alcoholic fatty liver disease. ML-262 does not induce cytotoxicity (up to 33 μM) or inhibit fatty acid uptake (up to 50 μM).
T78093	Cisd2 agonist 1	Others	Others
	Cisd2 agonist 1 (Compound 4q)为一种EC50值为34 nM的Cisd2激动剂，可增强Cisd2表达并改善非酒精性脂肪肝疾病（NAFLD）的病理改变，同时具备良好的代谢稳定性，适用于NAFLD研究。
T11448	GOAT-IN-1	Others	Others
	GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of diabetes, hyperlipidemia, non-alcoholic fatty liver, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral infa
T85263	13-methyl Pentadecanoic Acid methyl ester Methyl 13-methyl Pentadecanoate Acid	Others	Others
	13-Methylpentadecanoic acid methyl ester is a methylated version of fatty acid methyl ester detected in the bioactive fragment of A. malabarica extract, C. variabilis microalgae, and baboon liver. [Matreya, LLC. Catalog No. 1613]
T75150	GIP/GLP-1 dual receptor agonist-1	Others	Others
	GIP/GLP-1 dual receptor agonist-1 (化合物 4) 是一种 GIP/GLP-1双受体激动剂。GIP/GLP-1 dual receptor agonist-1 可用于代谢紊乱和脂肪肝病，包括非酒精性脂肪性肝炎 (NASH)、非酒精性脂肪性肝病 (NAFLD) 的研究。
T83421	1-Palmitoyl-sn-glycerol 3-phosphate 1-P-GPA	Others	Others
	1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA) 是内源性代谢物，常用于非酒精性脂肪性肝病的研究。
T84537	Δ2-cis Eicosenoic Acid	Others	Others
	Δ2-cisEicosenoic acid, an α,β-unsaturated fatty acid extracted and purified from fresh water clams, alongside its related compound 2-octadecenoic acid, which improves liver function and decreases blood sugar in streptozocin-induced diabetic rats, and its salts, holds potential medicinal value for treating diabetes and enhancing lipid metabolism.
T36607	(±)8-HDHA	Others	Others
	(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T35512	(±)16-HDHA	Others	Others
	(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T74132	GLP-1 receptor agonist 8	Others	Others
	GLP-1 receptoragonist 8 是一种有效的GLP-1R 激动剂。GLP-1 receptoragonist 8 具有研究糖尿病、肥胖和非酒精性脂肪肝 (NAFLD) 的潜力。
T62029	ML261	Others	Others
	ML261 是肝脂滴形成的抑制剂，IC50值为 69.7 nM。ML261 在非酒精性脂肪性肝病 (NAFLD) 和炎症中具有研究价值。
T84944	3-Epideoxycholic Acid EDCA	Others	Others
	3-Epideoxycholic acid (EDCA), a secondary bile acid and an epimer of deoxycholic acid, serves as a steroidal host compound in the enantioselective purification of (2R,3S)-3-methyl-2-pentanol from its racemates via enclathration. Additionally, decreased fecal levels of EDCA have been observed in pediatric patients with non-alcoholic fatty liver disease (NAFLD).
T21978	p-nitro-Pifithrin-α	Others	Others
	p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].
T35620	Ethoxyquin Dimer	Others	Others
	Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin .1 It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.2
T78313	Fazpilodemab BFKB8488A	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Fazpilodemab (BFKB8488A) 是靶向 FGFR1c 和 Klothoβ 的激动性人源化双特异性抗体，适用于T2DM或NAFLD的研究。
T84538	Δ2-trans Eicosenoic Acid	Others	Others
	Δ2-transEicosenoic acid, an α,β-unsaturated fatty acid, emerges as a by-product during the synthesis of Δ2-ciseicosenoic acid, which along with its salts, shows promise in diabetes treatment and lipid metabolism enhancement. Additionally, the compound 2-octadecenoic acid is recognized for its ability to enhance liver function and reduce blood sugar levels in streptozocin-induced diabetic rats.
T37652	5(S),6(R)-DiHETE	Others	Others
	5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. It is a weak LTD4 receptor agonist in guinea pig lung membranes. It induces guinea pig ileum contraction with an ED50 value of 1.3 μM.
T37408	Bischloroanthrabenzoxocinone	Others	Others
	Bacterial type II fatty acid synthesis (FAS-II) is mediated by a series of enzymes, each of which may be targeted by potential antibiotics. Bischloroanthrabenzoxocinone (BABX) is an inhibitor of FAS-II, blocking fatty acid synthesis in S. aureus and E. coli with IC50 values of 11.4 and 35.3 μg/ml, respectively. It inhibits the growth of S. aureus and permeable E. coli strains with minimum inhibitory concentrations ranging from 0.2-0.4 μg/ml. BABX also displays binding to liver X receptors (LXRs)...
T35508	(±)13-HDHA	Others	Others
	(±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra was shown to metabolize DHA to 13(R)-HDHA, presumably via the 11R-lipoxygenase activity. (±)13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T35443	1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol	Others	Others
	1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol is a triacylglycerol that contains palmitic , stearic , and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively. It has been detected in RAW 264.7 cells by neutral loss MS. Increased serum levels of 1-palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol are a potential biomarker for non-alcoholic fatty liver disease (NAFLD).
T37229	(±)8,9-DiHETE	Others	Others
	(±)8,9-DiHETE is a major metabolite of the 20:5 ω-3 fatty acid eicosapentaenoic acid .[1] It is produced in rat liver microsomes, but not renal microsomes, by the generation of the unstable intermediate 8,9-epoxy eicosatetraenoic acid from EPA by cytochrome P450 monooxygenases. Dietary EPA supplementation in humans results in substantial urinary excretion of vicinal diols, including 8,9, 11,12, and 14,15 forms.[2]
T35504	(±)10-HDHA	Others	Others
	(±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.[1][2] It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.[3][4][5] (±)10-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. Reference：[1]. VanRollins, M., and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate. J. Lipid Res. 25(5), 507-517 (1984).[2]. Reynaud, ...
T36606	(±)7-HDHA	Others	Others
	(±)7-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells and human neutrophils also produces 7-HDHA. However, the enzymatic product is most likely the S-isomer. (±)7-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T37405	Octanoyl Coenzyme A (sodium salt)	Others	Others
	Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD). Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase.
T35634	Platensimycin	Others	Others
	Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM). It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively). By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic ...
T69622	Ritivixibat	Others	Others
	Ritivixibat为回肠胆汁酸转运蛋白(IBAT)抑制剂，同时也是胆汁酸调节剂，主要适用于心血管疾病、脂肪酸代谢及葡萄糖利用障碍、胃肠道和肝脏疾病的研究。
T36602	(±)4-HDHA	Others	Others
	(±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells also produces 4-HDHA. However, the enzymatic product is most likely the S-isomer. (±)4-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T73762	11,12-DiHETrE	Others	Others
	11,12-DiHETrE，一种细胞色素P450 (P450) 类二十烷素内源性代谢产物，用于早产研究，并可作为区分NAFL(非酒精性脂肪肝)与NASH(非酒精性脂肪性肝炎)的生物标志物。
T85300	Palmitoleic Acid sodium C16:1(9Z),cis-Palmitoleic Acid,(9Z)-Hexadecenoic Acid,C16:1 n-7	Others	Others
	Palmitoleic acid, an ω-7 monounsaturated fatty acid found in macadamia and sea buckthorn oils, enhances both basal and insulin-stimulated glucose uptake, as well as Glut4 protein levels in 3T3-L1 adipocytes at a 200 µM concentration. Ex vivo, at a dosage of 300 mg/kg per day, it significantly increases glucose uptake and both aerobic and anaerobic glycolysis, while decreasing de novo fatty acid synthesis and the activity of lipogenic enzymes, specifically ATP citrate lyase (ACL) and glucose-6-ph...
T62277	PPARδ agonist 8	Others	Others
	Pparδ agonist 8 是一种 Pparδ 的有效激动剂。其中过氧化物酶体增殖物激活受体 (PPAR) 属于核内受体转录因子超家族，在体内代谢稳态、炎症、细胞生长和分化的调节中具有关键作用。Pparδ agonist 8 具有潜力进行非酒精性脂肪肝 (NAFLD) 的研究。
T72889	FXR agonist 4	Others	Others
	FXR agonist4，一种法尼酯X受体(FXR)激动剂，具有1.05 μM的EC50值。该化合物在DIO小鼠模型中有效地改善了高脂血症、肝脏脂肪变性、胰岛素抵抗以及肝脏炎症，因此可用于非酒精性脂肪性肝病(NAFLD)的研究。
T82719	Cisd2 agonist 2	Others	Others
	Cisd2 agonist 2（compound 6）是Cisd2激活剂，具有191 nM的EC50值，其中Cisd2水平与NAFLD相关。在Cisd2hKO-het小鼠（杂合子肝细胞特异性Cisd2敲除）中，Cisd2 agonist 2未显示出显著的体内毒性。
T78095	Demethyleneberberine chloride	NF-κB	NF-κB
	Demethyleneberberine chloride是一种具有线粒体靶向性的天然抗氧化剂，能通过抑制NF-κB通路及调节Th细胞平衡来缓解小鼠结肠炎并抑制炎症。此外，作为一种AMPK激活剂，该化合物亦用于非酒精性脂肪性肝病（NAFLD）的研究。
T80060	Pyruvate carboxylase	Endogenous Metabolite	Metabolism
	Pyruvate carboxylase是一种催化反应中丙酮酸与HCO3−和MgATP进行依赖性羧化生成草酰乙酸的含生物素酶。它在调控肝脏糖异生、脂肪细胞脂肪酸合成及胰腺β细胞胰岛素分泌方面，对全身能量平衡发挥关键作用。
T35881	Resolvin E2	Others	Others
	Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m...
T35505	(±)11-HDHA	Others	Others
	(±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelets and canine retina. In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets. 11(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5 μM, respe...

化合物

Cat.No: T12580

Target: COX, Epoxide Hydrolase

Cat.No: T2601

Synonym: SC12267,4sc-101

Target: Dehydrogenase, DNA/RNA Synthesis, Interleukin

Cat.No: T12883

Synonym: PBI-4050,3-戊基苯乙酸,Setogepram

Target: GPR

Cat.No: T6714

Synonym: KDS-4103,FAAH Inhibitor II

Target: Mitophagy, FAAH, Autophagy

Cat.No: T9010

Target: Others, AMPK

Cat.No: T38715

Synonym: MSDC-0602K,Azemiglitazone potassium

Target: PPAR

Cat.No: T9209

Synonym: STAT5 Inhibitor III,NSC 170984,R 6238,,Clesacostat

Target: Acetyl-CoA Carboxylase

Cat.No: T37184

Synonym: 2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid

Target: Phosphatase

Nrf2 activator-4

Cat.No: T63016

Target: Reactive Oxygen Species, Nrf2

Perhexiline maleate

Cat.No: T12408

Target: Others, Mitochondrial Metabolism

Cat.No: T26165

Target: Others

Cat.No: T68370

Target: Others

FXR/TGR5 agonist 1

Cat.No: T40302

Target: Others

12,15-epoxy-13-methyl-12,14-Eicosadienoic Acid

Cat.No: T85253

Synonym: Furan Fatty Acid F5

Target: Others

Cat.No: T35801

Target: Others

Cisd2 agonist 1

Cat.No: T78093

Target: Others

Cat.No: T11448

Target: Others

13-methyl Pentadecanoic Acid methyl ester

Cat.No: T85263

Synonym: Methyl 13-methyl Pentadecanoate Acid

Target: Others

GIP/GLP-1 dual receptor agonist-1

Cat.No: T75150

Target: Others

1-Palmitoyl-sn-glycerol 3-phosphate

Cat.No: T83421

Synonym: 1-P-GPA

Target: Others

Δ2-cis Eicosenoic Acid

Cat.No: T84537

Target: Others

Cat.No: T36607

Target: Others

Cat.No: T35512

Target: Others

GLP-1 receptor agonist 8

Cat.No: T74132

Target: Others

Cat.No: T62029

Target: Others

3-Epideoxycholic Acid

Cat.No: T84944

Synonym: EDCA

Target: Others

p-nitro-Pifithrin-α

Cat.No: T21978

Target: Others

Ethoxyquin Dimer

Cat.No: T35620

Target: Others

Cat.No: T78313

Synonym: BFKB8488A

Target: FGFR

Δ2-trans Eicosenoic Acid

Cat.No: T84538

Target: Others

5(S),6(R)-DiHETE

Cat.No: T37652

Target: Others

Bischloroanthrabenzoxocinone

Cat.No: T37408

Target: Others

Cat.No: T35508

Target: Others

1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol

Cat.No: T35443

Target: Others

Cat.No: T37229

Target: Others

Cat.No: T35504

Target: Others

Cat.No: T36606

Target: Others

Octanoyl Coenzyme A (sodium salt)

Cat.No: T37405

Target: Others

Cat.No: T35634

Target: Others

Cat.No: T69622

Target: Others

Cat.No: T36602

Target: Others

Cat.No: T73762

Target: Others

Palmitoleic Acid sodium

Cat.No: T85300

Synonym: C16:1(9Z),cis-Palmitoleic Acid,(9Z)-Hexadecenoic Acid,C16:1 n-7

Target: Others

PPARδ agonist 8

Cat.No: T62277

Target: Others

Cat.No: T72889

Target: Others

Cisd2 agonist 2

Cat.No: T82719

Target: Others

Demethyleneberberine chloride

Cat.No: T78095

Target: NF-κB

Pyruvate carboxylase

Cat.No: T80060

Target: Endogenous Metabolite

Cat.No: T35881

Target: Others

Cat.No: T35505

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T7529	Yamogenin 山药	Others	Others
	Yamogenin 是一种薯蓣皂素的非对映异构体。它通过抑制 HepG2 肝细胞中脂肪酸合成的基因表达来抑制甘油三酸酯 (TG) 的积累。它在萤光素酶配体测定中拮抗肝脏 X 受体 (LXR) 的激活。
T3324	Lycorine Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱	Apoptosis; Virus Protease; Antibacterial; AChR; Fatty Acid Synthase	Apoptosis; Metabolism; Microbiology/Virology; Neuroscience
	Lycorine (Narcissine) 是从金眼科植物科中提取的一种天然生物碱。它是一种具有口服活性的SCAP 抑制剂，Kd 值 15.24 nM。它也是黑色素瘤血管生成抑制剂，有用于前列腺癌和代谢疾病的研究潜力。
T37997	Murideoxycholic Acid	Endogenous Metabolite	Metabolism
	Murideoxycholic Acid 通过调节肠肝轴来缓解非酒精性脂肪性肝病。
T7732	Carbenoxolone Biogastrone,甘珀酸,Carbenoxolona,Carbenoxolone,Bioral	Dehydrogenase; Gap Junction Protein	Cytoskeletal Signaling; Metabolism
	Carbenoxolone (Carbenoxolona) 是 11β-HSD 和 gap junction connexin 通道的抑制剂。 Carbenoxolone 抑制巨噬细胞迁移到心房并防止脂肪肝的发展。
T4854	Acetoacetic acid lithium salt LithoTab acetoacetate,Lithium acetoacetate,Lithium 3-Oxobutyrate,乙酰乙酸锂	Others; Endogenous Metabolite	Metabolism; Others
	Acetoacetic acid lithium salt (Lithium 3-Oxobutyrate) 是内源性代谢产物的一种。
T0461L	Berberine sulfate AI3-61947,Berberin sulfate,Berberine sulphate,Berberal
	Berberine sulfate (Berberal) 是苄基异喹啉生物碱原小檗碱类的季铵盐，可用于研究2型糖尿病、腹部肥胖和代谢相关脂肪性肝病。
T3804	Neomangiferin Mangiferin 7-glucoside,新芒果苷	Phosphatase	Metabolism
	Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone，分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。
T3S1513	(20R)-Protopanaxadiol Protopanaxadiol,20R-Protopanaxadiol,(20R)-原人参二醇,(20R)-Protopanaxdiol	Others; Antibacterial	Microbiology/Virology; Others
	(20R)-Protopanaxadiol ((20R)-Protopanaxdiol) 是黑参中20(R)-人参皂甙 Rg3的一种三萜皂苷代谢物。它抑制幽门螺杆菌的生长，有抗肿瘤活性和细胞毒性。
T4867	Erucic acid Prifac 2990,芥酸,13(Z)-Docosenoic Acid,cis-13-docosenoic acid	PI3K; Endogenous Metabolite	Metabolism; PI3K/Akt/mTOR signaling
	Erucic acid (13(Z)-Docosenoic Acid) 是单不饱和脂肪酸，分离自萝卜的种子。Erucic acid 可以容易地穿过血脑屏障，使大脑中长链脂肪酸的积累正常化。Erucic acid 能够改善认知障碍并有效预防痴呆。
T4129	Arachidonic acid Immunocytophyte,花生四烯酸,arachidonate,Immunocytophyt,Vevodar	Others; Endogenous Metabolite	Metabolism; Others
	Arachidonic acid (Immunocytophyte) 属于天然产物，是一种不饱和的必需脂肪酸，是动物磷脂的成分。Arachidonic acid 由膳食亚油酸合成而成，是前列腺素、血栓素和白三烯生物合成的前体。
T37067	9-hydroxy Stearic Acid	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	9-hydroxy Stearic Acid 是一种羟基脂肪酸，是9-PAHSA 的活性代谢物。9-hydroxy Stearic Acid 是由9-PAHSA 通过肝脏和胰腺的羧基酯脂肪酶形成的。9-hydroxy Stearic Acid (5 μM)抑制HT-29结肠癌细胞裂解物中组蛋白去乙酰化酶1 (HDAC1)的表达。3 .当浓度为100 μM.1时，可抑制HT-29细胞的增殖，并诱导细胞周期阻滞于G0/ g1期。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 属于生物碱类天然产物，可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。
T4776	Glycerol Glycerin,甘油	Endogenous Metabolite	Metabolism
	Glycerol 是甘油三酯（即脂肪和油）和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
T4947	3-Hydroxybutyric acid Butanoic acid,3-羟基丁酸	Endogenous Metabolite	Metabolism
	3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物，在 I 型糖尿病中升高。它能够调节膜脂的性质。
TN5431	Icariside E4	Antioxidant; AMPK; Liver X Receptor; Lipid; Fatty Acid Synthase	Chromatin/Epigenetic; Metabolism; oxidation-reduction; PI3K/Akt/mTOR signaling
	Icariside E4是一种从小叶榆中提取得到天然化合物，通过AMPK 磷酸化和抑制HepG1细胞中MID1IP2的低脂化作用。Icariside E4具有抗伤害，抗氧化，抗阿尔茨海默氏症和抗炎作用，抑制了SREBP-1c，肝脏X 受体-α（LXR）和FASN 在HepG2细胞中从头脂肪生成的表达。Icariside E4是治疗脂肪肝疾病的有效候选药物，在HepG1细胞中具有低脂化潜力。
T37291	Lyso-Globotriaosylceramide (d18:1) Lyso-Globotriaosylceramide (d18:1)	Others	Others
	Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas...
T35624	Ajoene	Others	Others
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Cat.No: T7529

Synonym: 山药

Target: Others

Cat.No: T3324

Synonym: Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱

Target: Apoptosis, Virus Protease, Antibacterial, AChR, Fatty Acid Synthase

Murideoxycholic Acid

Cat.No: T37997

Target: Endogenous Metabolite

Cat.No: T7732

Synonym: Biogastrone,甘珀酸,Carbenoxolona,Carbenoxolone,Bioral

Target: Dehydrogenase, Gap Junction Protein

Acetoacetic acid lithium salt

Cat.No: T4854

Synonym: LithoTab acetoacetate,Lithium acetoacetate,Lithium 3-Oxobutyrate,乙酰乙酸锂

Target: Others, Endogenous Metabolite

Berberine sulfate

Cat.No: T0461L

Synonym: AI3-61947,Berberin sulfate,Berberine sulphate,Berberal

Cat.No: T3804

Synonym: Mangiferin 7-glucoside,新芒果苷

Target: Phosphatase

(20R)-Protopanaxadiol

Cat.No: T3S1513

Synonym: Protopanaxadiol,20R-Protopanaxadiol,(20R)-原人参二醇,(20R)-Protopanaxdiol

Target: Others, Antibacterial

Cat.No: T4867

Synonym: Prifac 2990,芥酸,13(Z)-Docosenoic Acid,cis-13-docosenoic acid

Target: PI3K, Endogenous Metabolite

Arachidonic acid

Cat.No: T4129

Synonym: Immunocytophyte,花生四烯酸,arachidonate,Immunocytophyt,Vevodar

Target: Others, Endogenous Metabolite

9-hydroxy Stearic Acid

Cat.No: T37067

Target: HDAC

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Cat.No: T4776

Synonym: Glycerin,甘油

Target: Endogenous Metabolite

3-Hydroxybutyric acid

Cat.No: T4947

Synonym: Butanoic acid,3-羟基丁酸

Target: Endogenous Metabolite

Cat.No: TN5431

Target: Antioxidant, AMPK, Liver X Receptor, Lipid, Fatty Acid Synthase

Lyso-Globotriaosylceramide (d18:1)

Cat.No: T37291

Synonym: Lyso-Globotriaosylceramide (d18:1)

Target: Others

Cat.No: T35624

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01878	L-FABP Protein, Human, Recombinant (His) fatty acid binding protein 1, liver,FABPL,...	Human	E. coli
	Fatty acid-binding protein, liver, also known as Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, FABP1 and FABPL,is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is t...
TMPH-02646	Erythroferrone Protein, Mouse, Recombinant (His) Erythroferrone,Myonectin,Erfe,Complement C1q tumor necrosis ...	Mouse	P. pastoris (Yeast)
	Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Erythroferrone Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted m...
TMPY-02481	ACOX1 Protein, Human, Recombinant (His) PALMCOX,ACOX,SCOX,acyl-CoA oxidase 1, palmitoyl	Human	Baculovirus Insect Cells
	Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a...
TMPY-00386	GLT8D2 Protein, Human, Recombinant (His) glycosyltransferase 8 domain containing 2,UNQ1901/PRO4347	Human	Baculovirus Insect Cells
	GLT8D2 is a glycosyltransferase of apoB100 that regulates apoB100 levels in hepatocytes. GLT8D2 expression increased in steatosis HepG2 cells compared with that in normal HepG2 cells. GLT8D2 participated in nonalcoholic fatty liver disease (NAFLD) pathogenesis possibly by negatively regulating MTP expression.
TMPH-01301	Erythroferrone Protein, Human, Recombinant (His & SUMO) Myonectin,Erythroferrone,ERFE,Complement C1q tumor necrosis ...	Human	E. coli
	Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake.
TMPY-03222	PNLIP Protein, Human, Recombinant (His) PL,pancreatic lipase,PTL,PNLIPD	Human	HEK293 Cells
	PNLIP is an enzyme that belongs to the lipase family. Secreted from the pancreas, PNLIP is the primary lipase that hydrolyzes dietary fat molecules in the human digestive system, converting triglyceride substrates found in ingested oils to monoglycerides and free fatty acids. Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which a...
TMPY-01563	PMP2 Protein, Human, Recombinant (His) MP2,FABP8,peripheral myelin protein 2,P2,M-FABP	Human	E. coli
	Myelin P2 protein, also known as PMP2, is a cytosolic protein found primarily in peripheral nerves. It Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. PMP2 is a small, basic, and cytoplasmic lipid binding protein of peripheral myelin. It is similar in amino acid sequence and tertiary structure to fatty acid binding proteins found in the liver, adipocytes, and intestine, its expression is limited to the nervous system. PMP2 is detected only in myelin-producing cells ...
TMPY-03756	BBOX1 Protein, Human, Recombinant (His & GST) butyrobetaine (γ), 2-oxoglutarate dioxygenase (γ-butyrobetai...	Human	Baculovirus Insect Cells
	BBOX1, also known as gamma-BBH, belongs to thegamma-BBH/TMLD family. It is highly expressed in kidney and moderately expressed in liver. BBOX1 catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. BBOX1 is an inhibition target for mildronate which can be used to treatanginaandmyocardial infarctio...
TMPJ-00460	MECR Protein, Human, Recombinant (His) Nuclear Receptor-Binding Factor 1,HsNrbf-1NRBF-1,MECR,NBRF1,...	Human	HEK293 Cells
	Trans-2-Enoyl-CoA Reductase Mitochondrial (MECR) belongs to the zinc-containing alcohol dehydrogenase family. MECR localizes to the mitochondrion. It is highly expressed in skeletal and heart muscle and expressed at lower levels in the placenta, liver, kidney and pancreas, with weakly or no expression in the lung. MECR exists as a homodimer, which catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain...
TMPY-03109	PHYH Protein, Human, Recombinant PHYH1,RD,PAHX,LN1,phytanoyl-CoA 2-hydroxylase,LNAP1	Human	E. coli
	PHYH belongs to the family of iron(II)-dependent oxygenases, which typically incorporate one atom of dioxygen into the substrate and one atom into the succinate carboxylate group. PHYH is expressed in liver, kidney, and T-cells, but not in spleen, brain, heart, lung and skeletal muscle. It converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. Defects in PHYH can cause Refsum disease (RD). RD is an autosomal recessive disorder characterized clinically by a tetrad of abnormalities: retinitis pigmentos...
TMPJ-00758	AFP Protein, Mouse, Recombinant (His) Alpha-fetoprotein,α-fetoglobulin,Alpha-1-fetoprotein,Afp,α-1...	Mouse	HEK293 Cells
	Alpha-fetoprotein (AFP) is classified as a member of the albuminoid gene superfamily consisting of albumin, AFP, vitaminD (Gc) protein, and alpha-albumin. AFP is a major plasma protein produced by the yolk sac and the liver during fetal development. It is thought to be the fetal form of serum albumin. AFP binds to copper, nickel, fatty acids and bilirubin and is found in monomeric, dimeric and trimeric forms. AFP is one of the several embryo-specific proteins and is adominant serum protein as ea...
TMPY-01770	HAO1 Protein, Human, Recombinant (His) GOX1,hydroxyacid oxidase (glycolate oxidase) 1,GOX,HAOX1	Human	E. coli
	Hydroxyacid oxidase 1, also known as Glycolate oxidase, HAO1, and GOX1, is a member of the FMN-dependent alpha-hydroxy acid dehydrogenase family. HAO1 / GOX1 has 2-hydroxyacid oxidase activity. It is most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. HAO1 / GOX1 is a liver-specific peroxisomal enzyme that oxidizes glycolate to glyoxylate with the concomitant production of H2O2. In H...
TMPY-01427	AACS Protein, Human, Recombinant (His) SUR-5,acetoacetyl-CoA synthetase,ACSF1	Human	Baculovirus Insect Cells
	Acetoacetyl-CoA Synthetase (AACS) is a novel cytosolic ketone body (acetoacetate)-specific ligase. The AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. It had been improved that Acetoacetyl-CoA Synthetase is an essential enzyme for the synthesis of fatty acid and cholesterol from ketone bodies, was found to be highly expressed in mouse adipose tissue, and GC box and C/EBPs motif were crucial for AACS promoter ...
TMPY-04813	ACAT2 Protein, Rat, Recombinant (His) acetyl-CoA acetyltransferase 2	Rat	E. coli
	Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two enzymes are involved in storing cholesteryl esters as lipid droplets, in macrophage foam-cell formation, in absorbing dietary cholesterol, and in supplying cholesteryl esters as part of the core lipid for lipoprotein synthesis and assembly. The key difference in tissue distributio...
TMPY-02181	PLA2G12B Protein, Mouse, Recombinant (His) Fksg71,2010002E04Rik,Pla2g13,hlb218,phospholipase A2, group ...	Mouse	HEK293 Cells
	Group XIIB secretory phospholipase A2-like protein, also known as Group XIII secretory phospholipase A2-like protein, GXIII sPLA2-like, sPLA2-GXIIB, GXIIB, PLA2G13 and PLA2G12B, is a secreted protein that belongs to the phospholipase A2 family. PLA2G12B / PLA2G13 is strongly expressed in liver, small intestine and kidney. Mammalian secretory phospholipase A2s ( sPLA2s ) form a family of structurally related enzymes that are involved in a variety of physiological and pathological processes via th...

重组蛋白

L-FABP Protein, Human, Recombinant (His)

Cat.No: TMPY-01878

Species: Human

Expression System: E. coli

Erythroferrone Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02646

Species: Mouse

Expression System: P. pastoris (Yeast)

ACOX1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02481

Species: Human

Expression System: Baculovirus Insect Cells

GLT8D2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00386

Species: Human

Expression System: Baculovirus Insect Cells

Erythroferrone Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01301

Species: Human

Expression System: E. coli

PNLIP Protein, Human, Recombinant (His)

Cat.No: TMPY-03222

Species: Human

Expression System: HEK293 Cells

PMP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01563

Species: Human

Expression System: E. coli

BBOX1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03756

Species: Human

Expression System: Baculovirus Insect Cells

MECR Protein, Human, Recombinant (His)

Cat.No: TMPJ-00460

Species: Human

Expression System: HEK293 Cells

PHYH Protein, Human, Recombinant

Cat.No: TMPY-03109

Species: Human

Expression System: E. coli

AFP Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00758

Species: Mouse

Expression System: HEK293 Cells

HAO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01770

Species: Human

Expression System: E. coli

AACS Protein, Human, Recombinant (His)

Cat.No: TMPY-01427

Species: Human

Expression System: Baculovirus Insect Cells

ACAT2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04813

Species: Rat

Expression System: E. coli

PLA2G12B Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02181

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0052	Propionicacid-d5
	Propionicacid-d5 是 Propionicacid 的氘代化合物。Propionicacid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中，并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中，作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。
TMIJ-0054	Propionic-2,2-d2 acid
	Propionic-2,2-d2 acid 是 Propionic acid 的氘代化合物。Propionic acid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中，并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中，作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。

同位素标记化合物

Propionicacid-d5

Cat.No: TMIJ-0052

Propionic-2,2-d2 acid

Cat.No: TMIJ-0054

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