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Targets Recommended: Bradykinin Receptor

119

抑制剂 & 化合物

18

天然产物

2

化合物库

13

重组蛋白

7

同位素标记化合物

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Cat. No.	Product Name
L9410	共价抑制剂库		1920 compounds
	1920 种小分子的独特集合，包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子，如氯乙酰基，2-氯丙酰基，丙烯酰基，1-丙-2-炔基，1-丁-2-炔基，酮羰基，二硫键等，可以用于共价抑制剂药物研发；
L9830	抗帕金森病化合物库		857 compounds
	857 种帕金森病相关的化合物集合，可用于高通量和高内涵筛选；

化合物库

共价抑制剂库

Cat.No: L9410

Compounds: 1920

抗帕金森病化合物库

Cat.No: L9830

Compounds: 857

Cat. No.	Product Name	Target	Signaling Pathways
T2086	ELN-441958 ELN 441958	Bradykinin Receptor	GPCR/G Protein
	ELN-441958是一种B1受体拮抗剂，能够抑制B1激动剂配体[3H] DAKD 与IMR-90细胞结合(Ki:0.26 nM)，相较于B2受体，它对B1受体的抑制作用具有更高的选择性，且比抑制μ阿片受体选择性高500多倍，比抑制δ阿片受体选择性高2000多倍。
T15430	GSK2256294A GSK 2256294	Others; Epoxide Hydrolase	Metabolism; Others
	GSK2256294A (GSK 2256294) 是重组人、大鼠和小鼠 sEH 的有效特异性抑制剂，IC50 分别为 27 pM、61 pM 和 189 pM。
T21995	XAP044	GluR	Neuroscience
	XAP044 是高效的选择性mGlu7拮抗剂。代谢型谷氨酸受体亚型 7 是哺乳动物 CNS 中神经传递的重要突触前调节剂。它在啮齿动物行为测试中表现出较好的大脑暴露、广谱抗应激、抗抑郁以及抗焦虑作用。
T1812	KX1-004 KX1 004,KX1004	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	KX1-004 是非 ATP 竞争性 Src-PTK 抑制剂，IC50=40 μM。它能够保护耳蜗，使其免受有害噪音的影响，并防止噪音引起的听力损失 (NIHL)。
T20039	7-Methyladenine NSC7857,7-甲基腺嘌呤,NSC-7857,NSC 7857	Others	Others
	7-Methyladenine (NSC-7857) 可用作暴露于外源性和致癌性甲基化剂的标志物。
T0601	Monobenzyl phthalate 邻苯二甲酸单苄酯,Phthalic Acid Monobenzyl Ester	Others; Endogenous Metabolite	Metabolism; Others
	Phthalic Acid Monobenzyl Ester 是一种暴露于邻苯二甲酸盐(如，邻苯二甲酸二乙基己酯)后的尿代谢物 (urinary metabolite)，具有雌激素作用。。
T8547	DCBA	Drug Metabolite	Metabolism
	DCBA 是驱虫剂 N-N-diethyl-meta-toluamide (DEET) 的代谢物。尿液中 DCBA 的浓度是评估 DEET 暴露程度的指标。
T36478	BI-6901	CCR	Immunology/Inflammation; Microbiology/Virology
	BI-6901 是一种选择性 CCR10 拮抗剂。在DNFB接触超敏反应的小鼠模型中，BI 6901 以剂量依赖的方式显示其抗炎反应。
TQ0039	(±)-Zanubrutinib (±)-BGB-3111	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	(±)-Zanubrutinib ((±)-BGB-3111) 是一种有效的口服Bruton’s 酪氨酸激酶(Btk)抑制剂，具有优越的口服生物利用度，可实现更高的暴露量和更完整的靶点抑制。
T19310	Ensulizole 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID,苯基苯丙咪唑磺酸,2-Phenyl-1H-benzo[d]imidazole-5-sulfonic acid,Phenylbenzimidazole sulfonic acid	Others	Others
	Ensulizole 是磺化的紫外线吸收剂，可以强烈吸收 UVB 和部分 UVA。在紫外线或阳光照射下，它可以产生活性氧，进而破坏 DNA。
T0976	Propoxur 残杀威,Aprocarb,Propoxure,Baygon	AChR; Antifungal	Microbiology/Virology; Neuroscience
	Propoxur (Propoxure) 是一种氨基甲酸酯类杀虫剂，用于控制蟑螂、苍蝇、蚊子以及草坪和草坪昆虫。
T3106	C-DIM12	Apoptosis; Others	Apoptosis; Others
	C-DIM12是一种人工合成的Nurr1激活剂，可诱导Nurr1和DA 基因表达。
T35501	5,6-trans-Vitamin D3 5,6-trans-Colecalciferol,5,6-trans-Cholecalciferol,Cholecalciferol EP Impurity A	Vitamin	Metabolism
	5,6-trans-Vitamin D3（5,6-trans-Cholecalciferol）是维生素 D3 的异构体，经光照后在皮肤表面由 Vitamin D3 转化而来。
T17315	(±)-CPSI-1306 cpsi-1306,2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one	Others	Others
	(±)-CPSI-1306 (2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one) 是一种巨噬细胞迁移抑制因子 (MIF) 拮抗剂，可用于关于非胰岛素依赖型糖尿病 (NIDDM) 的研究以及预防急性和慢性 UVB 暴露对皮肤的有害影响。
T21404	Fluticasone furoate Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate	Glucocorticoid Receptor	Endocrinology/Hormones
	Fluticasone furoate (Avamys) 是一种合成的三氟化皮质类固醇，衍生自氟替卡松，Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。
T22341	GSK-114	Others	Others
	GSK 114 是口服有活性的、高选择性的TNNI3K 抑制剂 (IC50= 25 nM)。其中TNNI3K (又称 CARK) 是酪氨酸样激酶家族的成员，选择性在心脏组织中表达。它对 TNNI3K 的选择性是 B-Raf 激酶的 40 倍 (IC50= 1 µM)。
T0357	Potassium iodide	Tyrosinase	Proteases/Proteasome
	Potassium iodide 用于治疗过度活跃的甲状腺，并保护甲状腺免受吞咽或吸入放射性碘的辐射影响。可在意外接触放射性碘后或服用含放射性碘的药物前后使用。
TP1179L	Porcine dynorphin A(1-13) acetate Dynorphin A Porcine Fragment 1-13 acetate,Porcine dynorphin A(1-13) acetate(72957-38-1 free base)	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Porcine dynorphin A(1-13) acetate (Dynorphin A Porcine Fragment 1-13 acetate)(72957-38-1 free base) 是一种有效的内源性 κ opioid 受体激动剂，在生理浓度下具有镇痛作用。暴露于强啡肽 A (1-13) 会导致单个神经元中 [Ca2+]i 的急剧增加，类似于急性 NMDA 治疗所见的增加。
T1435	Praziquantel 吡喹酮,Pyquiton,Droncit,Biltricide	Calcium Channel; Antibiotic; Parasite	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Praziquantel (Droncit) 是一种外消旋混合物，由 (R)-Praziquantel 和 (S)-Praziquantel 组成。它可研究血吸虫病。
T1787	Levobupivacaine	Sodium Channel	Membrane transporter/Ion channel
	Levobupivacaine 是一种氨基酰胺类局麻药，属于n-alkylsubstituted pipecoloxylidide 家族。它是bupivacaine 的 S-对映异构体。
T38003	Levofloxacin N-oxide	Others	Others
	Levofloxacin N-oxide 是从左氧氟沙星中分离出来的杂质。
T36141	Boscalid	Mitochondrial Metabolism	Metabolism
	Boscalid 是一种广谱羧酰胺类杀菌剂，通过与线粒体复合物 II/琥珀酸脱氢酶的泛醌位点结合来抑制真菌呼吸。
T39136	ATX inhibitor 7	Others	Others
	ATX inhibitor 7 is a autotaxin inhibitor and shows good oral exposure.
T8675	Vaniprevir	Others	Others
	Vaniprevir is a macrocyclic hepatitis C virus NS3/4a protease inhibitor and is active against both the genotype 1 and genotype 2 NS3/4a protease enzymes. vaniprevir has good plasma exposure and excellent liver exposure in multiple species.
T26525	ABT-281 ABT 281,A-86281,A 86281,ABT281,A86281	Others	Others
	ABT-281 is an ascomycin analog and a macrolactam T cell inhibitors with potent topical activity and reduced systemic exposure.
T34777	Talaporfin free acid Monoaspartyl chlorin,NPe6,Talaporfin,Aspartyl chlorin	Others	Others
	Talaporfin, an effective tumor localizer, can produce the selective degradation of tumor tissue following light exposure.
T29689	AFB1-N7-guanine	Others	Others
	In epidemiological studies, Aflatoxin B1-N7-guanine serum albumin adducts have been established as biomarkers of dietary aflatoxin exposure.
T71091	Y2-Antagonist-2	Others	Others
	Y2-Antagonist-2 is a novel, selective, soluble non-peptidic NPY Y2 receptor antagonist with enhanced CNS exposure.
T68335	MK-1220	Others	Others
	MK-1220 is a novel Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure.
T70223	UA8967	Others	Others
	UA8967 is a membrane-active anti-tumor agent. Cytotoxicity studies in six pancreatic cancer cell lines, one normal human pancreatic ductal epithelial line and two colon cancer cells showed the IC50s UA8967 ranged from 12–61 μM for exposure times of 72 h. There was also no selective inhibition of DNA, RNA or protein synthesis after exposure to UA8967. UA8967 is observed to affect the plasma membrane.
T14879	CB 300919	Others	Others
	CB 300919 is a quinazoline-based antitumor agent with high activity in the CH1 human ovarian tumor xenograft and has continuous exposure (96 h) growth inhibition (IC50: 2 nM).
T16372	Obidoxime dichloride	Others	Others
	Obidoxime dichloride, a selective oxime agent, effectively reactivates sarin-inhibited acetylcholinesterase (AChE) and mitigates the acute toxicity associated with sarin exposure. It is also utilized as an antidote for organophosphate nerve agent poisoning.
T6060L	Anabasine HCl BB-NC-0036,CCG-38440,H-8174,AR-1H7273,ZX-BK000320,ST-24041653	Others	Others
	Anabasine HCl is used as a clinical biomarker for tobacco smoke exposure and as an insecticide. It is also a depolarizing NMJ blocker, aromatase inhibitor, nAChr antagonist, and teratogen found in species of Nicotiana.
T30691	Calcium diglutamate Calcium di-L-glutamate,Glutamic acid, calcium salt (2:1), L-	Others	Others
	Calcium diglutamate(CDG), calcium acid salt of glutamic acid. As a soluble source of calcium ions, this chemical is used as a first-aid treatment for exposure to hydrofluoric acid.
T35236	5α-Hydroxy-6-keto cholesterol YS 64,Yakkasterone,5α-羟基-6-酮胆固醇	Others	Others
	Yakkasterone is a major metabolite of cholesterol formed during exposure of lung epithelial cells to ozone.
T69607	Dersimelagon phosphate	Others	Others
	Dersimelagon phosphate is a selective melanocortin-1 receptor (MC1R) agonist that increases skin melanin without sun exposure and is being developed to increase light tolerance in EPP/XLP patients.
T61174	MT-134	Others	Others
	MT-134 是一种 SkMII 特异性抑制剂，在肌肉中具有良好的暴露性。
T70608	cis-Entacapone	Others	Others
	cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone. It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure.
T14570	BI 99179 BI99179	Fatty Acid Synthase	Metabolism
	BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and central) upon oral administration in rats[1].
T35458	(R)-nitro-Blebbistatin	Others	Others
	(R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin , which is the inactive form of (-)-blebbistatin . Prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (R)-nitro-Blebbistatin has the same stereoche...
T26573	AG311 AG 311,AG-311	Others	Others
	AG311 is an inhibitor of complex I and hypoxia-induced HIF-1α stabilization. In vitro, AG311 induces rapid necrosis in numerous cancer cell lines. Within minutes, exposure to AG311 also results in mitochondrial depolarization, superoxide production, and i
T31194	Dalapon Basfapon B,Dowpon M,Dawpon-Rae	Others	Others
	Dalapon is a selective herbicide used to control perennial grasses. The major use of dalapon is on food crops including sugarcane and sugar beets. Its use is no longer authorized in France. The National Institute for Occupational Safety and Health in the
T38267	Valeryl-L-carnitine (chloride) Valeryl-L-carnitine (chloride),L-Valerylcarnitine	Others	Others
	Valeryl-L-carnitine is a short-chain acylcarnitine and a derivative of L-carnitine . Valeryl-L-carnitine levels increase in the serum of rhesus monkeys following exposure to 7 and 10 Gray units (Gy) of ionizing radiation.[1]
T40397	3,4,6-Trichlorocatechol	Others	Others
	3,4,6-Trichlorocatechol (TCC) is a metabolite generated by the post-mitochondrial liver fraction in Aroclor-1254 induced rats, resulting from exposure to industrial pollutants.
T26821	BIPM	Others	Others
	BIPM is a potent inhibitor of Rho-associated protein kinase 2 (ROCK2). Exposure of SH-SY5Y cells to BIPM led to significant changes in cell migration, actin stress fibers and neurite length. BIPM significantly inhibits phosphorylation of cofilin, a regula
T37704	Olanzapine Lactam Impurity	Others	Others
	Olanzapine lactam impurity is a potential impurity found in commercial preparations of olanzapine.1It is a degradation product formed by exposure to thermal or oxidative stress. 1.Baertschi, S.W., Brunner, H., Bunnell, C.A., et al.Isolation, identification, and synthesis of two oxidative degradation products of olanzapine (LY170053) in solid oral formulationsJ. Pharm. Sci.97(2)883-892(2008)
T40226	FP-Biotin	Others	Others
	FP-biotin is a potent organophosphorus toxicant, ideal for identifying novel biomarkers of organophosphorus toxicant exposure. It measures FAAH, ABHD6, and MAG-lipase activity, specifically in plasma studies, due to the efficient purification of biotinylated peptides through binding to immobilized avidin beads.
T85274	2-hydroxy Myristic Acid methyl ester	Others	Others
	2-Hydroxy Myristic Acid Methyl Ester, a rare hydroxylated fatty acid methyl ester isolated from aquatic microbial sources, experiences a decrease in levels to <1% within these communities following Atradex pesticide exposure at 245 mg/L concentration. [Matreya, LLC. Catalog No. 1704]
T85217	Cholesteryl Palmitoleate Cholesterol Palmitoleate,16:1(9Z) Cholesterol ester,CE(16:1),16:1(9Z) CE	Others	Others
	Cholesteryl palmitoleate, a cholesterol ester, exhibits elevated plasma levels in ApoE-/- mice following exposure to cigarette smoke and in pediatric patients diagnosed with biliary atresia. It serves as a standard for identifying cholesterol esters in human meibomian gland secretions.
T11986	Mebeverine acid Mebeverine metabolite Mebeverine acid,美贝维林酸	Drug Metabolite	Metabolism
	Mebeverine acid (Mebeverine metabolite Mebeverine acid) 是美贝维林的次级代谢产物，可用作口服美贝维林的标志物。

化合物

Cat.No: T2086

Synonym: ELN 441958

Target: Bradykinin Receptor

Cat.No: T15430

Synonym: GSK 2256294

Target: Others, Epoxide Hydrolase

Cat.No: T21995

Target: GluR

Cat.No: T1812

Synonym: KX1 004,KX1004

Target: Src

7-Methyladenine

Cat.No: T20039

Synonym: NSC7857,7-甲基腺嘌呤,NSC-7857,NSC 7857

Target: Others

Monobenzyl phthalate

Cat.No: T0601

Synonym: 邻苯二甲酸单苄酯,Phthalic Acid Monobenzyl Ester

Target: Others, Endogenous Metabolite

Cat.No: T8547

Target: Drug Metabolite

Cat.No: T36478

Target: CCR

(±)-Zanubrutinib

Cat.No: TQ0039

Synonym: (±)-BGB-3111

Target: BTK

Cat.No: T19310

Synonym: 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID,苯基苯丙咪唑磺酸,2-Phenyl-1H-benzo[d]imidazole-5-sulfonic acid,Phenylbenzimidazole sulfonic acid

Target: Others

Cat.No: T0976

Synonym: 残杀威,Aprocarb,Propoxure,Baygon

Target: AChR, Antifungal

Cat.No: T3106

Target: Apoptosis, Others

5,6-trans-Vitamin D3

Cat.No: T35501

Synonym: 5,6-trans-Colecalciferol,5,6-trans-Cholecalciferol,Cholecalciferol EP Impurity A

Target: Vitamin

Cat.No: T17315

Synonym: cpsi-1306,2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one

Target: Others

Fluticasone furoate

Cat.No: T21404

Synonym: Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate

Target: Glucocorticoid Receptor

Cat.No: T22341

Target: Others

Potassium iodide

Cat.No: T0357

Target: Tyrosinase

Porcine dynorphin A(1-13) acetate

Cat.No: TP1179L

Synonym: Dynorphin A Porcine Fragment 1-13 acetate,Porcine dynorphin A(1-13) acetate(72957-38-1 free base)

Target: Opioid Receptor

Cat.No: T1435

Synonym: 吡喹酮,Pyquiton,Droncit,Biltricide

Target: Calcium Channel, Antibiotic, Parasite

Levobupivacaine

Cat.No: T1787

Target: Sodium Channel

Levofloxacin N-oxide

Cat.No: T38003

Target: Others

Cat.No: T36141

Target: Mitochondrial Metabolism

ATX inhibitor 7

Cat.No: T39136

Target: Others

Cat.No: T8675

Target: Others

Cat.No: T26525

Synonym: ABT 281,A-86281,A 86281,ABT281,A86281

Target: Others

Talaporfin free acid

Cat.No: T34777

Synonym: Monoaspartyl chlorin,NPe6,Talaporfin,Aspartyl chlorin

Target: Others

AFB1-N7-guanine

Cat.No: T29689

Target: Others

Y2-Antagonist-2

Cat.No: T71091

Target: Others

Cat.No: T68335

Target: Others

Cat.No: T70223

Target: Others

Cat.No: T14879

Target: Others

Obidoxime dichloride

Cat.No: T16372

Target: Others

Cat.No: T6060L

Synonym: BB-NC-0036,CCG-38440,H-8174,AR-1H7273,ZX-BK000320,ST-24041653

Target: Others

Calcium diglutamate

Cat.No: T30691

Synonym: Calcium di-L-glutamate,Glutamic acid, calcium salt (2:1), L-

Target: Others

5α-Hydroxy-6-keto cholesterol

Cat.No: T35236

Synonym: YS 64,Yakkasterone,5α-羟基-6-酮胆固醇

Target: Others

Dersimelagon phosphate

Cat.No: T69607

Target: Others

Cat.No: T61174

Target: Others

Cat.No: T70608

Target: Others

Cat.No: T14570

Synonym: BI99179

Target: Fatty Acid Synthase

(R)-nitro-Blebbistatin

Cat.No: T35458

Target: Others

Cat.No: T26573

Synonym: AG 311,AG-311

Target: Others

Cat.No: T31194

Synonym: Basfapon B,Dowpon M,Dawpon-Rae

Target: Others

Valeryl-L-carnitine (chloride)

Cat.No: T38267

Synonym: Valeryl-L-carnitine (chloride),L-Valerylcarnitine

Target: Others

3,4,6-Trichlorocatechol

Cat.No: T40397

Target: Others

Cat.No: T26821

Target: Others

Olanzapine Lactam Impurity

Cat.No: T37704

Target: Others

Cat.No: T40226

Target: Others

2-hydroxy Myristic Acid methyl ester

Cat.No: T85274

Target: Others

Cholesteryl Palmitoleate

Cat.No: T85217

Synonym: Cholesterol Palmitoleate,16:1(9Z) Cholesterol ester,CE(16:1),16:1(9Z) CE

Target: Others

Mebeverine acid

Cat.No: T11986

Synonym: Mebeverine metabolite Mebeverine acid,美贝维林酸

Target: Drug Metabolite

Cat. No.	Product Name	Target	Signaling Pathways
TN7118	Methylhippuric acid Methyl hippurate,N-苯甲酰基甘氨酸甲酯
	Methylhippuric acid (Methyl hippurate) 是人体尿液中二甲苯暴露的生物标志物。
T4931	Dihydroxyfumaric acid hydrate	Others; Endogenous Metabolite	Metabolism; Others
	Dihydroxyfumaric acid hydrate 是内源性代谢产物的一种。
T5S1550	Cinnamyl alcohol 肉桂醇,肉桂醇；beta-苯丙烯醇,Cinnamic Alcohol,Styryl Carbinol	PPAR	DNA Damage/DNA Repair; Metabolism
	Cinnamyl alcohol (Styryl Carbinol) 是从板栗花中分离得到的一种活性成分，抑制增加的 PPARγ表达，具有抗肥胖作用。
T19082	1-Hydroxypyrene 1-Pyrenol,Pyren-1-ol,1-羟基芘	Endogenous Metabolite	Metabolism
	1-Hydroxypyrene (1-Pyrenol) 是一种暴露于多环芳烃的生物标志物，存在尿液样本中，也是一种暴露于 pyrenes 中的主要生物标志物。
T5718	L-(+)-Abrine L-(+)-红豆碱,L-N-Methyltryptophan,N-α-Methyl-L-tryptophan,L-ABRINE	Others	Others
	L-(+)-Abrine (L-N-Methyltryptophan) 是一种致命白蛋白，发现于在 Abrus precatorius 种子中，是一种急性毒性生物碱，可用作化学标记物。
T3746	Dimethyl phthalate 邻苯二甲酸二甲酯,Solvanom,Avolin,Fermine,避蚊酯	Others	Others
	Dimethyl phthalate (Fermine) 是一种邻苯二甲酸酯 (PAEs)，是一种已知的内分泌干扰物，也是一种普遍存在的污染物。它常作为增塑剂，赋予硬质聚氯乙烯 (PVC) 树脂以柔韧性。
T1659	Melatonin Melatonine,松果体素,N-Acetyl-5-methoxytryptamine,褪黑素	CaMK; Apoptosis; Mitophagy; Estrogen/progestogen Receptor; Melatonin Receptor; Glutathione Peroxidase; Endogenous Metabolite; ROR; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience
	Melatonin (Melatonine) 是一种由松果体制成的激素，可激活褪黑激素受体。它在睡眠中起作用，有抗氧化和抗炎特性。它是新型选择性ATF-6抑制剂，可诱导细胞凋亡。
T4787	2-Hydroxyisobutyric acid 2-甲基-2-羟基丙酸,α-Hydroxyisobutyric acid	Others; Endogenous Metabolite	Metabolism; Others
	2-Hydroxyisobutyric acid (α-Hydroxyisobutyric acid) 是内源性代谢产物的一种。
T2S0633	Raspberry ketone Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone,覆盆子酮	PPAR	DNA Damage/DNA Repair; Metabolism
	Raspberry ketone (p-Hydroxybenzyl acetone) 是覆盆子中主要的芳香族天然产物，主要用作化妆品的香料和食品增味剂，也可作 PPAR-α激动剂。
T5S0018	Betulonic acid 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid	Parasite; HSV	Microbiology/Virology
	Betulonic acid (Liquidambaric acid) 是一种在许多植物中存在的三萜类天然产物，具有抗肿瘤，抗炎，抗寄生虫和抗病毒的活性。
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T3S0013	Ethyl trans-caffeate 咖啡酸乙酯,Ethyl caffeate,Caffeic Acid Ethyl Ester	Others	Others
	Ethyl trans-caffeate (Caffeic Acid Ethyl Ester) 具有抗炎作用。它是一种有前途的天然化合物，未来在慢性肝病中的应用。它是一种有效的化学预防化合物，可防止因太阳紫外线照射引起的皮肤癌变。它是与人胰腺α-淀粉酶复合的代表性抑制剂的高分辨率结构。它强烈抑制 JB6 Cl41细胞的肿瘤转化，无毒性。 PI3K、ERK1/2 和 p38 激酶活性在体外通过与 HOEC 直接结合而受到抑制。
T37280	PE(18:1(9Z)/0:0)	Endogenous Metabolite	Metabolism
	PE(18:1(9Z)/0:0) 是一种天然存在的溶血磷脂，是缩醛磷脂溶血磷脂酰乙醇胺的类似物。 PE(18:1(9Z)/0:0) 以浓度依赖性方式诱导 PC12 大鼠神经元细胞中细胞内钙的瞬时增加。 PE(18:1(9Z)/0:0) 增加 IL-4 和 IL-2 的产生，但不增加 IFN-γ 的产生。在小鼠血清中，PE(18:1(9Z)/0:0)（1 μg/动物）诱导 T 辅助细胞 2 反应。在寒冷暴露三天后，小鼠肩胛间棕色脂肪组织中的 PE(18:1(9Z)/0:0) 水平增加。
TN4026	Eucamalol	Others	Others
	Eucamolol exhibits significant repellent activity against Aedes albopictus, and inhibits its feeding as well as DEET, is effective repellent (75%) up to 3 h after exposure to mosquito.
TN1766	(-)-Integerrimine Integerrimine,全緣千里光鹼,全缘千里光碱	Others	Others
	Prenatal exposure to Integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delayed in physical and behavioral development of the offspring. Doses of Integerrimine N-oxide here employed did not produce marked immunotoxic effects.
T83108	Anhuienoside B	Others	Others
	Anhuienoside B为从C. anhuiensis K. F. Wu鲜叶中提取的天然产物，能应对CuCl2诱导的非生物胁迫。
T40859	5-Hydroxy-8-methoxypsoralen 5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen	Others	Others
	5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite derived from Xanthotoxin, which acts as a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). It is employed as an agent for the treatment of psoriasis, eczema, vitiligo, and certain cutaneous Lymphomas, in combination with phototherapy involving exposure to sunlight.
T80950	Tricetin 7-O-glucoside
	Tricetin 7-O-glucoside (compound 33)为一种黄酮类单-O-糖苷。

天然产物

Methylhippuric acid

Cat.No: TN7118

Synonym: Methyl hippurate,N-苯甲酰基甘氨酸甲酯

Dihydroxyfumaric acid hydrate

Cat.No: T4931

Target: Others, Endogenous Metabolite

Cinnamyl alcohol

Cat.No: T5S1550

Synonym: 肉桂醇,肉桂醇；beta-苯丙烯醇,Cinnamic Alcohol,Styryl Carbinol

Target: PPAR

1-Hydroxypyrene

Cat.No: T19082

Synonym: 1-Pyrenol,Pyren-1-ol,1-羟基芘

Target: Endogenous Metabolite

Cat.No: T5718

Synonym: L-(+)-红豆碱,L-N-Methyltryptophan,N-α-Methyl-L-tryptophan,L-ABRINE

Target: Others

Dimethyl phthalate

Cat.No: T3746

Synonym: 邻苯二甲酸二甲酯,Solvanom,Avolin,Fermine,避蚊酯

Target: Others

Cat.No: T1659

Synonym: Melatonine,松果体素,N-Acetyl-5-methoxytryptamine,褪黑素

Target: CaMK, Apoptosis, Mitophagy, Estrogen/progestogen Receptor, Melatonin Receptor, Glutathione Peroxidase, Endogenous Metabolite, ROR, Autophagy

2-Hydroxyisobutyric acid

Cat.No: T4787

Synonym: 2-甲基-2-羟基丙酸,α-Hydroxyisobutyric acid

Target: Others, Endogenous Metabolite

Raspberry ketone

Cat.No: T2S0633

Synonym: Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone,覆盆子酮

Target: PPAR

Cat.No: T5S0018

Synonym: 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid

Target: Parasite, HSV

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Ethyl trans-caffeate

Cat.No: T3S0013

Synonym: 咖啡酸乙酯,Ethyl caffeate,Caffeic Acid Ethyl Ester

Target: Others

PE(18:1(9Z)/0:0)

Cat.No: T37280

Target: Endogenous Metabolite

Cat.No: TN4026

Target: Others

(-)-Integerrimine

Cat.No: TN1766

Synonym: Integerrimine,全緣千里光鹼,全缘千里光碱

Target: Others

Cat.No: T83108

Target: Others

5-Hydroxy-8-methoxypsoralen

Cat.No: T40859

Synonym: 5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen

Target: Others

Tricetin 7-O-glucoside

Cat.No: T80950

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03407	NQO1 Protein, Human, Recombinant (His) NAD(P)H dehydrogenase, quinone 1,NMORI,DIA4,QR1,NMOR1,DTD,DH...	Human	E. coli
	NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered ex...
TMPH-02153	Sulfiredoxin-1 Protein, Human, Recombinant (His & Myc) SRXN1,Sulfiredoxin-1	Human	E. coli
	Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.
TMPK-00516	BST1 Protein, Cynomolgus, Recombinant (His) Bp-3,CD157,Bst1,BST-1,Ly65,Bp3,Antigen BP3	Cynomolgus	HEK293 Cells
	BST1 overexpression conferred resistance to sphingosine in yeast. BST1 deletion produced sensitivity to exogenous D-erythro-sphingosine and phytosphingosine and intracellular accumulation of sphingosine 1-phosphate upon exposure to exogenous sphingosine. sphingoid base metabolism is similar in all eukaryotes and suggests that yeast genetics may be useful in the isolation and identification of other genes involved in sphingolipid signaling and metabolism.
TMPH-01676	Meteorin-like/METRNL Protein, Human, Recombinant (His & SUMO) METRNL,Meteorin-like protein,Subfatin	Human	E. coli
	Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the a...
TMPH-03614	DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO) DNA photolyase,Deoxyribodipyrimidine photo-lyase,phr,phrA,Ph...	Synechococcus	E. coli
	Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 74.3 kDa and the accession number is P05...
TMPJ-01107	PAP Protein, Human, Recombinant (His) PAP1,PAP,PDGFA-Associated Protein 1,HASPP28,28 kDa Heat- and...	Human	E. coli
	Human PAP, also known as 28 kDa heat- and acid-stable phosphoprotein, PDGF-associated protein, PDGFA-associated protein 1, PDAP1, HASPP28, is a protein which belongs to the PDAP1 family. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. PDGF-Associated Protein (PAP) is a phosphoprotein that may enhance PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. PDAP1 expression is induced by TNF-alpha, and cells overexpressing PDAP1 sho...
TMPJ-00018	CCL16 Protein, Human, Recombinant NCC-4,Lymphocyte and Monocyte Chemoattractant,LMC,NCC4,HCC-4...	Human	E. coli
	CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC chemokines, showing less than 30% sequence identity. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8. Recombinant CCL16 has been shown to chemoattract human monocytes and THP1 cells but not resting lymphocyt...
TMPH-00201	BK polyomavirus (BKPyV) VP2 Protein (His) Minor capsid protein VP2,Minor structural protein VP2	BKPyV	E. coli
	Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm. Nuclear entry of the viral DNA ...
TMPY-03851	BPIFB1 Protein, Human, Recombinant (His) LPLUNC1,BPI fold containing family B, member 1,C20orf114	Human	HEK293 Cells
	BPIFB1, also known as LPLUNC1, belongs to the BPI/LBP/Plunc superfamily, plunc family. BPIFB1 may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. BPIFB1 is expressed in the upper respiratory tract and oral cavity, which may function in host defence. The expression of BPIF proteins is associated with CF lung disease in humans and mice. It is unclear if this elevation of protein production, which results from phenotypic alteration of the cel...
TMPH-02365	JC polyomavirus (JCV) Minor capsid protein VP2 (His) Minor capsid protein VP2,Minor structural protein VP2	JCPyV	E. coli
	Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm. Nuclear entry of the viral DNA ...
TMPJ-00748	Ig kappa Protein, Human, Recombinant (His) Ig κ chain C region AG,Ig κ,Ig kappa chain C region AG,Ig ka...	Human	HEK293 Cells
	Immunoglobulin Kappa is constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humo...
TMPH-00789	Hamster polyomavirus (HaPyV) VP1 Protein (His & Myc) Major structural protein VP1,Major capsid protein VP1	HaPyV	E. coli
	Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with sialic acids on the cell surface to provide virion attachment to target cell. Once attached, the virion is internalized by endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby...
TMPJ-00837	LAMP1 Protein, Mouse, Recombinant (His) Lysosomal membrane glycoprotein A,CD107a,LAMP-1,CD107 antige...	Mouse	HEK293 Cells
	Lysosomal associated membrane protein 1 (LAMP1) is an approximately 120 kDa transmembrane glycoprotein that is a major protein component of lysosomal membranes. Mature mouse LAMP1 consists of a 346 amino acid (aa) intralumenal domain (ECD), a 24 aa transmembrane segment, and a 12 aa cytoplasmic tail. Its lumenal domain is organized into two heavily N-glycosylated regions separated by a Ser/Pro-rich linker that carries a minor amount of O-linked glycosylation. Within the lumenal domain, mouse LAM...

重组蛋白

NQO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03407

Species: Human

Expression System: E. coli

Sulfiredoxin-1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02153

Species: Human

Expression System: E. coli

BST1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00516

Species: Cynomolgus

Expression System: HEK293 Cells

Meteorin-like/METRNL Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01676

Species: Human

Expression System: E. coli

DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03614

Species: Synechococcus

Expression System: E. coli

PAP Protein, Human, Recombinant (His)

Cat.No: TMPJ-01107

Species: Human

Expression System: E. coli

CCL16 Protein, Human, Recombinant

Cat.No: TMPJ-00018

Species: Human

Expression System: E. coli

BK polyomavirus (BKPyV) VP2 Protein (His)

Cat.No: TMPH-00201

Species: BKPyV

Expression System: E. coli

BPIFB1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03851

Species: Human

Expression System: HEK293 Cells

JC polyomavirus (JCV) Minor capsid protein VP2 (His)

Cat.No: TMPH-02365

Species: JCPyV

Expression System: E. coli

Ig kappa Protein, Human, Recombinant (His)

Cat.No: TMPJ-00748

Species: Human

Expression System: HEK293 Cells

Hamster polyomavirus (HaPyV) VP1 Protein (His & Myc)

Cat.No: TMPH-00789

Species: HaPyV

Expression System: E. coli

LAMP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00837

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0322	Mebeverine Acid-d5
	Mebeverine Acid-d5 是 Mebeverine Acid 的氘代化合物。Mebeverine Acid 的 CAS 号为 475203-77-1。Mebeverine acid 是美贝维林的次级代谢产物，可用作口服美贝维林的标志物。
TMIJ-0526	Dibutyl Phthalate-d4
	Dibutyl Phthalate-d4 是 Dibutyl Phthalate 的氘代化合物。Dibutyl Phthalate 的 CAS 号为 84-69-5。Dibutyl phthalate 是一种用于大多数塑料的增塑剂，存在于水、空气、土壤、植物和动物中。长期接触可能会产生一些不利影响。
TMIJ-0412	Phthalic acid, bis-isobutyl ester-d4
	Phthalic acid, bis-isobutyl ester-d4 是 Phthalic acid, bis-isobutyl ester 的氘代化合物。Phthalic acid, bis-isobutyl ester 的 CAS 号为 84-69-5。Dibutyl phthalate 是一种用于大多数塑料的增塑剂，存在于水、空气、土壤、植物和动物中。长期接触可能会产生一些不利影响。
TMIJ-0505	Fluticasone Furoate-d3
	Fluticasone Furoate-d3 是 Fluticasone Furoate 的氘代化合物。Fluticasone Furoate 的 CAS 号为 397864-44-7。Fluticasone furoate 是一种合成的三氟化皮质类固醇，衍生自氟替卡松，Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。
TMID-0153	MELATONIN(ACETYL-d3)
	MELATONIN(ACETYL-d3) 是 MELATONIN 的氘代化合物。MELATONIN 的 CAS 号为 73-31-4。Melatonin 是一种由松果体制成的激素，可激活褪黑激素受体。它在睡眠中起作用，有抗氧化和抗炎特性。它是新型选择性ATF-6抑制剂，可诱导细胞凋亡。
T35517	4-deoxy Nivalenol-13C15 4-deoxy Nivalenol-13C15
	4-deoxy Nivalenol-13C15is intended for use as an internal standard for the quantification of 4-deoxy nivalenol by GC- or LC-MS. 4-deoxy Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It binds to eukaryotic ribosomes and inhibits protein synthesis in mice when administered at doses ranging from 5 to 25 mg/kg. 4-deoxy Nivalenol (0.1 and 0.2 mg/kg) induces emesis in pigs and decreases feed consumption in pigs when administered at a dose of 40 ppb in the diet.2It induces leth...
T35775	HT-2 Toxin-13C22 HT-2 Toxin-13C22
	HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human...

同位素标记化合物

Mebeverine Acid-d5

Cat.No: TMIH-0322

Dibutyl Phthalate-d4

Cat.No: TMIJ-0526

Phthalic acid, bis-isobutyl ester-d4

Cat.No: TMIJ-0412

Fluticasone Furoate-d3

Cat.No: TMIJ-0505

MELATONIN(ACETYL-d3)

Cat.No: TMID-0153

4-deoxy Nivalenol-13C15

Cat.No: T35517

Synonym: 4-deoxy Nivalenol-13C15

HT-2 Toxin-13C22

Cat.No: T35775

Synonym: HT-2 Toxin-13C22

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