94
17
8
16
2
Cat. No. | Product Name | ||
---|---|---|---|
L2151 | 化疗药物库 | 48 compounds | |
48 个肿瘤化疗药物,可以用于高通量和高内涵筛选; | |||
L2191 | 抗乳腺癌化合物库 | 1939 compounds | |
1939 种与乳腺癌相关的化合物,可以用于抗乳腺癌药物研发和药理研究; | |||
L2194 | 抗结直肠癌化合物库 | 1545 compounds | |
1545 种与结直肠癌相关的化合物,可以用于高通量和高内涵筛选; | |||
L9410 | 共价抑制剂库 | 1920 compounds | |
1920 种小分子的独特集合,包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子,如氯乙酰基,2-氯丙酰基,丙烯酰基,1-丙-2-炔基,1-丁-2-炔基,酮羰基,二硫键等,可以用于共价抑制剂药物研发; | |||
L2192 | 抗胰腺癌化合物库 | 2238 compounds | |
2238 种与胰腺癌相关的化合物,可以用于高通量和高内涵筛选; | |||
L8400 | 血液病分子库 | 514 compounds | |
514 种造血系统疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L2190 | 抗肺癌化合物库 | 1702 compounds | |
1702 种与肺癌相关的化合物,可以用于抗肺癌药物研发和药理研究; | |||
L2170 | 肿瘤免疫治疗小分子化合物库 | 449 compounds | |
449 种靶向肿瘤免疫治疗靶点的小分子,可用于高通量和高内涵筛选,是研究肿瘤免疫治疗的有力工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2747 |
Endothall
|
Phosphatase; Others | Metabolism; Others |
Endothall 是蛋白磷酸酶 2A (PP2A) 抑制剂,能够抑制PP2A (IC50: 90 nM) 和 PP1 (IC50: 5 uM) 。它可作为除草剂,在癌症化疗过程中也能够发挥作用。 | |||
T21876 |
DC_AC50
|
Apoptosis; Others | Apoptosis; Others |
DC_AC50 是一种 Atox 和 CCS 的双抑制剂,是一种抑制细胞内铜伴侣作为减少/预防获得性化疗耐药性的手段。它与 Atox1 和 CCS 结合并减少癌细胞增殖和肿瘤生长。 | |||
T22746 |
Tesmilifene fumarate
DPPE fumarate |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Tesmilifene fumarate (DPPE fumarate) 是一种 H1C 受体拮抗剂,可增强化疗的细胞毒性且保护正常细胞。 | |||
T9271 |
RAD51-IN-1
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RAD51-IN-1 是 B02 的衍生物,是一种RAD51的有效抑制剂,可研究癌症。 | |||
T1564 |
Cisplatin
cis-Diaminodichloroplatinum,CDDP,顺铂 |
DNA Alkylator/Crosslinker; Ferroptosis; DNA/RNA Synthesis; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Cisplatin (CDDP) 是一种 DNA 交联剂。Cisplatin 具有抗肿瘤活性,能够通过在癌细胞中形成 DNA 加合物来抑制 DNA 合成。Cisplatin 还可激活铁死亡并诱导自噬。 | |||
T1414 |
Sodium 2-mercaptoethanesulfonate
Mitexan,美司那,美司钠,Uromitexan,Mesna,Mesnum,Mesnex |
Others | Others |
Sodium 2-mercaptoethanesulfonate (Uromitexan) 是一种抗氧化剂,具有细胞保护作用。它可用于减轻由环磷酰胺引起的出血性膀胱炎。它广泛用作抗化学疗法毒性的全身保护剂。 | |||
T1528 |
Azasetron hydrochloride
Y-25130 hydrochloride,Y-25130 HCl,盐酸阿扎司琼,Azasetron HCl |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Azasetron hydrochloride (Y-25130 HCl) 是一种苯甲酰胺的衍生物,是有效的、选择性的5-HT3受体拮抗剂,可用于化疗引起的恶心呕吐研究。 | |||
T1478 |
Ondansetron hydrochloride dihydrate
盐酸昂丹司琼,SN 307,NSC 665799,GR 38032,Ondansetron hydrochloride |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Ondansetron hydrochloride dihydrate (GR 38032) 是5- HT3受体拮抗剂,可治疗化疗后的恶心和呕吐,有抗焦虑和抗精神病作用。 | |||
T2047 |
AG-1478
AG1478,NSC 693255,Tyrphostin AG-1478 |
EGFR; HCV Protease; Influenza Virus; HER; PDGFR | Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
AG-1478 (NSC-693255) 是一种选择性 EGFR 酪氨酸激酶抑制剂,IC50为 3 nM。它对 HCV 和脑心肌炎病毒有抗病毒作用。 | |||
T1790 |
Fosaprepitant dimeglumine
福沙匹坦二甲葡胺,L785298,福沙吡坦二甲葡胺,MK-0517,Fosaprepitant dimeglumine salt |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Fosaprepitant dimeglumine (MK-0517) 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂,可用于预防化疗引起的恶心呕吐。 | |||
T16871 |
Semustine
|
DNA Alkylator/Crosslinker | DNA Damage/DNA Repair |
Semustine 是一种 DNA 烷化剂,是一种癌症化疗化合物,在接受辅助化疗的恶性黑色素瘤患者中具有肾毒性,可用于辅助治疗白血病。 | |||
T21899 |
Misonidazole
SR-1354,SR1354,Ro 7-0582 |
GPX | oxidation-reduction |
Misonidazole 是一种缺氧肿瘤细胞放射增敏剂,具有抗菌活性。 | |||
T28187 |
Nonabine
|
Others | Others |
Nonabine 是一种具有强烈止吐作用的化合物,可用来预防与癌症化疗有关的恶心和呕吐。 | |||
T22313 |
Dolasetron Mesylate
多拉司琼甲磺酸盐,甲磺酸多拉司琼,Anzemet hydrate,MDL-73147EF |
Others; 5-HT Receptor | GPCR/G Protein; Neuroscience; Others |
Dolasetron Mesylate (MDL-73147EF) 是 5-HT3 受体的拮抗剂,可用于治疗化疗后呕吐和恶心的研究。 | |||
T24184 |
Itasetron
DAU6215CL,UNII-00S0D0OEKR,U-98079A,U 98079A,DAU 6215CL |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Itasetron (U 98079A) 是一种5-羟色胺3受体拮抗剂,可用于预防大鼠与年龄有关的记忆缺陷。Itasetron 在癌症化疗和放疗动物模型中的止吐活性,可用于研究健忘症。 | |||
T4568 |
Dolasetron
MDL-73147,多拉司琼 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Dolasetron (MDL-73147) 是一种血清素 5-HT3 受体拮抗剂,用于治疗化疗后的恶心和呕吐。 | |||
T10244 |
ACY-1083
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
ACY-1083 是一种选择性和脑穿透性 HDAC6 抑制剂 (IC50:3 nM),可有效逆转化疗引起的周围神经病变。 | |||
T68068L |
(R)-CJ 11974
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
T6616 |
Ondansetron hydrochloride
SN 307,盐酸昂丹司琼,帕罗西汀杂质A,Ondansetron HCl,Emeset,GR 38032 HCl,NSC 665799,Zofran |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Ondansetron hydrochloride (Zofran) 是5-HT3受体的拮抗剂,可用作化疗后止吐剂。 | |||
T1042 |
Granisetron hydrochloride
盐酸格拉司琼,BRL 43694A,Granisetron HCl |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Granisetron hydrochloride (Granisetron HCl) 是一种5-HT3受体拮抗剂,可作为化疗后止吐剂。 | |||
T1755 |
LY2090314
|
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
LY2090314 是GSK-3抑制剂,抑制 GSK-3α (IC50:1.5 nM) 和 GSK-3β (IC50:0.9 nM)。 | |||
T0776 |
Phenothiazine
ENT 38,吩噻嗪 |
Dopamine Receptor; Antibacterial; Antibiotic; Antifungal | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Phenothiazine (ENT 38) 是一种抗生素,具有杀虫,抗菌,驱虫和杀真菌活性。它也可研究神经系统疾病。 | |||
T79303 |
IACS-52825
|
Others | Others |
IACS-52825是一种选择性DLK抑制剂,具有1.3 nM的Kd值,适用于研究化疗引起的周围神经病变。 | |||
T28935 | TDRL-551 | Others | Others |
TDRL-551 是一种新型有效的复制蛋白A (RPA) 抑制剂 (IC50=18 µM),具有潜在的抗癌活性。TDRL-551 对 RPA-DNA 相互作用有抑制作用,提高以铂为基础的肺癌和卵巢癌化疗的疗效。 | |||
T6127 |
Rucaparib Phosphate
AG-014699 phosphate,PF-01367338,芦卡帕利,AG-014699,瑞卡帕布磷酸盐,PF-01367338 phosphate |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Rucaparib Phosphate (PF-01367338 phosphate) 是一种口服有效的PARP 蛋白抑制剂,对 PARP-1 的Ki 为 1.4 nM。它是六磷酸己糖脱氢酶 (H6PD) 抑制剂,有用于去势抵抗性前列腺癌 (CRPC) 的研究潜力。 | |||
T3716 |
Rolapitant
罗拉吡坦,SCH619734,罗拉匹坦 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Rolapitant (SCH619734) 是一种高效选择性具有口服活性的神经激肽 1 受体抑制剂,Ki 值为0.66 nM。 | |||
T76788 |
Demcizumab
OMP 21M18 |
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
Demcizumab (OMP 21M18) 是一种抗 DLL4 单克隆抗体。Demcizumab 是一种有效的 Notch 通路抑制剂。Demcizumab 在多种癌症模型中无论使单独还联合化疗试剂使用都是有效的。 | |||
T2589 |
Dolasetron Mesylate hydrate
Dalasetron Mesylate Hydrate,多拉司琼甲磺酸盐一水合物 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Dolasetron Mesylate hydrate (Dalasetron Mesylate Hydrate) 是一种选择性血清素受体拮抗剂,可竞争性阻断血清素对 5HT3 受体的作用,从而抑制化疗和放疗引起的恶心和呕吐。 | |||
T9955 |
EX-A5758
|
NOS | Immunology/Inflammation |
EX-A5758是一种新型推定的小分子 nNOS-NOS1 AP 抑制剂,可抑制炎症性伤害感受和化疗引起的神经性疼痛,并与紫杉醇协同降低肿瘤细胞活力 | |||
T4451 |
Estramustine phosphate sodium
Ro 21-8837/001,Estramustine phosphate disodium,雌莫司汀磷酸钠 |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Estramustine phosphate sodium (Ro 21-8837/001) 是雌二醇类似物,是一种具有口服活性抗微管化疗剂,通过与微管相关蛋白和微管蛋白结合而使微管解聚。它可诱导前列腺癌细胞凋亡,可研究前列腺癌。 | |||
T4684 |
ML241 hydrochloride
|
p97 | Ubiquitination |
ML241 hydrochloride 是一种有效且选择性的 p97 ATPase 抑制剂,IC50值为 100 nM。 | |||
T15611 |
JH-RE-06
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
JH-RE-06是一种REV1-REV7互作抑制剂,IC50为0.78 μM,Kd 为0.42 μM。它靶向与 POLζ 的 REV7 亚基相互作用的 REV1,可改善化疗效果。它通过阻止诱变 POLζ 的募集来破坏诱变性跨损伤合成。 | |||
T2283 |
PX-12
2-[(1-甲基丙基)二硫代]-1H-咪唑,IV-2,PX12 |
Thioredoxin | Metabolism |
PX-12 (PX12) 是一种可逆的硫氧还蛋白-1(Trx-1)抑制剂,能够抑制 MCF-7 细胞(IC50:1.9 μM)和HT-29 细胞(IC50:2.9 μM)的生长。 | |||
T3614 |
Inosine pranobex
Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun |
IL Receptor; HIV Protease | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Inosine pranobex (Delimmun) 是一种免疫增强剂,它是一种广谱抗病毒剂,用于 HIV 感染。 | |||
T2265 |
Bimiralisib
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2 |
Others; PI3K; S6 Kinase; mTOR | MAPK; Others; PI3K/Akt/mTOR signaling |
Bimiralisib (PI3K-IN-2) 是一种有效的,可渗透脑的 mTOR/PI3K 抑制剂,是一种 mTORC1和 mTORC2抑制剂。它能够抑制 PI3Kα,PI3Kδ,PI3Kβ,PI3Kγ和 mTOR,IC50分别为 33 nM,451 nM,661 nM,708 nM 和 89 nM。 | |||
T22393 |
Palonosetron
RS25259,帕洛诺司琼,RS 25259 197 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). | |||
T29486 |
7-Methotrexate
7-Mtx |
Others | Others |
7-Methotrexate is used as a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions. | |||
T29391 |
3'-Chloromethotrexate
NSC 29631,NSC29631,SKI 23338,NSC-29631,AI3-50533 |
Others | Others |
3'-Chloromethotrexate is a chemotherapy agent and immune system suppressant. It can be used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions. | |||
T1120L |
Dacarbazine hydrochloride
Dacarbazine HCl |
Others | Others |
Dacarbazine ( imidazole carboxamide) is a chemotherapy drug used to treat melanoma and Hodgkin's lymphoma. | |||
T26283 |
TNP-351
Tnp 351 |
Others | Others |
Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer. | |||
T68274 |
QZ59S-SSS
|
Others | Others |
QZ59S-SSS acts as a potential inhibitor of human P-glycoprotein and may be used to improve the efficacy of cancer chemotherapy. | |||
T31977 |
GLYN
NSC 137875,NSC137875,Glycidyl nitrate,NSC-137875 |
Others | Others |
GLYN, a nitric oxide donor, acts by enhancing the therapeutic efficacy of chemotherapy and radiotherapy. | |||
T25929 |
Pemetrexed tromethamine
Pemetrexed ditromethamine dihydrate |
Others | Others |
Pemetrexed tromethamine is a chemotherapy drug used for pleural mesothelioma and non-small cell lung cancer. | |||
T22340 |
Granisetron
Sustol,Granisetronum,格拉司琼,Sancuso,Kevatril |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Granisetron, a serotonin receptor (5HT-3 selective) antagonist, is used as an antinauseant and antiemetic for cancer chemotherapy. | |||
T30041 |
Amphoglucamine
|
Others | Others |
Amphoglucamine is used in the combined chemotherapy of viral diseases. | |||
T70114 |
Paclitaxel Ceribate
|
Others | Others |
Paclitaxel Ceribate is a mitotic inhibitor used in cancer chemotherapy. | |||
T71123 |
RG 12915
|
Others | Others |
RG 12915 is a potent, selective 5-HT3 receptor antagonist developed for the treatment of emesis and nausea associated with cancer chemotherapy. | |||
T31837 |
FOLFIRI Regimen
FOLFIRI |
Others | Others |
FOLFIRI Regimen is a chemotherapy regimen consisting of leucovorin calcium (calcium folinate), 5-fluorouracil, and irinotecan used during the treatment of advanced-stage and metastatic colorectal cancer. | |||
T10015 |
1-Deazaadenosine
|
Others | Others |
1-Deazaadenosine is a potent Adenosine deaminase inhibitor (Ki: 0.66 μM). It exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders. | |||
T29965 |
Amethopterin
DL-Amethopterin |
Others | Others |
Amethopterin is a chemotherapy drug and immune system inhibitor used to treat cancers of the blood, bone, lung, breast, head, and neck. In addition, it can treat rheumatoid arthritis and psoriasis. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2217 |
Cephalomannine
Baccatin III,三尖杉宁碱 |
Microtubule Associated | Cytoskeletal Signaling |
Cephalomannine (Baccatin III) 是一种从云南红豆杉中提取的紫杉醇衍生物,具有抗肿瘤活性,可用于癌症研究。 | |||
T21936 |
M50054
2,2′-亚甲基双(1,3-环己二酮) |
Caspase | Apoptosis; Proteases/Proteasome |
M50054 是一种有效的细胞凋亡抑制剂,可用于研究抗 Fas 抗体引起的肝炎和化疗引起的脱发。它抑制 Etoposide 诱导的 U937 细胞 caspase-3 活化,IC50为 79 μg/mL。 | |||
T0132 |
Etoposide
VP-16,依托泊苷,依托泊甙,VP-16-213 |
Apoptosis; Mitophagy; Topoisomerase; Antibacterial; Antibiotic; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Microbiology/Virology |
Etoposide (VP-16-213) 是一种拓扑异构酶 II 的抑制剂,通过与拓扑异构酶 II 和 DNA 形成复合物来抑制 DNA 合成 (IC50=60.3 μM)。Etoposide 具有抗肿瘤活性,可以诱导细胞凋亡、自噬。 | |||
T6431 |
Levoleucovorin Calcium
左亚叶酸钙,Calcium Levofolinate,CL307782 |
Others; Antifolate | Cell Cycle/Checkpoint; Others |
Levoleucovorin Calcium (CL307782) 是一种亚叶酸的钙盐,在癌症化疗中用作辅助剂。 | |||
T22286 |
Cyanosafracin B
Cyanoquinonamine,氰基番红菌素 B,CBR28-1 |
Others | Others |
Cyanosafracin B (Cyanoquinonamine) 是一种合成 Phthalascidin Pt-650 及 Ecteinascidin ET-743 的起始原料。 | |||
T1285 |
Anethole trithione
茴三硫,Anetholtrithion |
Others; AChR | Neuroscience; Others |
Anethole trithione (Anetholtrithion) 是硫杂环胆碱,是一种胆汁分泌刺激剂,可增强唾液分泌并增加 mAChR 受体,用于口干症的研究。 | |||
T1156 |
Palonosetron hydrochloride
盐酸帕洛诺司琼,RS 25259 197,Palonosetron HCl,RS 25259 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Palonosetron hydrochloride (RS 25259) 是一种 5-HT3 拮抗剂,用于预防和治疗化疗引起的恶心和呕吐。 | |||
T3924 |
Astragaloside II
黄芪皂苷 II,Astrasieversianin VIII |
TGF-beta/Smad | Stem Cells |
Astragaloside II (Astrasieversianin VIII) 是一种分离自黄芪中的天然化合物。 | |||
T4735 |
2'-Deoxyuridine 5'-monophosphate disodium
2'-脱氧尿苷-5'-单磷酸二钠,2'-dUMP⋅2Na,2-脱氧尿嘧啶核苷-5'-单磷酸二钠盐,2'-Deoxyuridine 5'-monophosphate disodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
2'-Deoxyuridine 5'-monophosphate disodium (2'-dUMP⋅2Na) salt 能够被双底物酶胸苷酸合酶(TS) 还原甲基化为 dTMP (2'-deoxythymidine 5'-monophosphate)。其中 dTMP 是 DNA 合成所需的核苷酸。 | |||
T2S1120 |
Ganoderenic acid B
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
Ganoderenic acid B 是一种从Ganoderma lucidum 中提取的天然产物,可以通过抑制ABCB1的转运功能,增强化疗药物对ABCB1介导的耐多药癌细胞的细胞毒性来发挥作用。 | |||
T4S0094 |
Hydroxygenkwanin
羟基芫花素,Luteolin 7-methylether,7-O-Methylluteolin |
Antioxidant | oxidation-reduction |
Hydroxygenkwanin (Luteolin 7-methylether) 是一种丁香达芙妮的主要成分,是一种天然的类黄酮化合物。它具有抗氧化,抗神经胶质瘤能力和抗癌作用。 | |||
T3729 |
Ethyl gallate
Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯 |
MMP; NF-κB; Akt; Antibacterial | Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。 | |||
T2563 |
Acetyl-L-carnitine hydrochloride
Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) 是一种由内源性左旋肉碱的乙酰化形式的盐酸盐组成的营养补充剂,具有潜在的神经保护、认知增强、抗抑郁和免疫调节活性。还可缓解化疗、糖尿病或其他疾病引起的周围神经病变。此外,乙酰左旋肉碱可能通过增加T淋巴细胞成熟来调节免疫反应,并可能下调促炎细胞因子对病毒(如SARS-CoV-2)的反应。它还可能破坏ACE2信号通路并抑制活性氧(ROS)的产生。 | |||
T37984 |
Fosfructose, sodium salt, hydrate (1:3:8)
D-Fructose-1,6-bisphosphate , sodium salt, hydrate (1:3:8) |
Others | Others |
D-Fructose-1,6-bisphosphate sodium salt hydrate 是碳水化合物代谢的中间体,包括糖酵解和糖异生。在糖酵解过程中,它是由磷酸果糖激酶磷酸化果糖-6-磷酸产生的。由果糖-1,6-二磷酸酶-1介导的逆反应是糖异生的限速步骤之一。同样的反应也发生在植物的叶绿体中,D-Fructose-1,6-bisphosphate sodium salt hydrate 作为还原性戊糖磷酸循环的一部分。由于癌细胞采用糖酵解作为代谢能量产生的主要来源,这一途径已成为癌症化疗的主要靶点。 | |||
T35000 |
Uproleselan sodium
GMI 1271,GMI1271,GMI-1271 |
Others | Others |
Uproleselan sodium (GGI-1271) is a small molecule E-selector antagonist originally targeted at AML as an adjuvant to standard chemotherapy for hematological malignancies. | |||
T3S0205 |
β-Hederin
Beta-Hederin,β-常春藤素 |
Parasite | Microbiology/Virology |
β-Hederin 是从 Hedera helix L.(Araliaceae) 分离得到的一种皂苷,具有抗利什曼虫活性。它对乳腺癌细胞有凋亡作用,有望成为乳腺癌化疗的候选药物。 | |||
T66078 |
Cardamonin
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Others | Others |
Cardamonin, a chalcone extracted from cardamom spice with anti-inflammatory and anti-tumor activities. Cardamonin decreased viability of NPC(Nasopharyngeal carcinoma ) cells in a concentration-dependent manner. The IC50 values were 16.22 μM(CNE-1), 14.34 μM (CNE-2), 16.50 μM (HONE-1), and 68.12 μM (SUNE-1). Moreover, the expression level of the proapoptotic effector protein Bax and Bid was also markedly increased after treatment with cardamonin(15μM) in CNE-2 cells.In vivo, cardamonin (25 mg/kg ... |
Cat. No. | Product Name | Species | Expression System |
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TMPY-04830 |
GAS6 Protein, Mouse, Recombinant (His)
growth arrest-specific 6,Gas-6 |
Mouse | HEK293 Cells |
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor... | |||
TMPY-00025 |
Mammaglobin B/SCGB2A1 Protein, Human, Recombinant (hFc)
UGB3,MGB2,LPNC,LPHC,LIPHC,secretoglobin family 2A member 1 |
Human | HEK293 Cells |
SCGB2A1 represented a novel, prognostic factor for CRC, and that expression of SCGB2A1 correlated with chemoresistance, radioresistance and cancer cell stemness. SCGB2A1 is a top differentially expressed gene in all major histological types of ovarian cancers and may represent a novel and attractive target for the immunotherapy of patients harbouring recurrent disease resistant to chemotherapy. | |||
TMPK-00410 |
AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
ARK,EC 2.7.10.1,EC 2.7.10,Axl,JTK11,AXL oncogene,UFO,AI32364... |
Human | HEK293 Cells |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein (Primary Amine Labeling), Human, Rec... | |||
TMPK-00408 |
AXL Protein, Human, Recombinant (His & Avi), Biotinylated
AXL oncogene,EC 2.7.10.1,AI323647,Axl,JTK11,ARK,EC 2.7.10,UF... |
Human | HEK293 Cells |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi), Bio... | |||
TMPK-00357 |
CD229 Protein, Human, Recombinant (His & Avi)
LY9,T100,AI893573,SLAMF3,Lgp100,CD229 |
Human | HEK293 Cells |
CD229 was strongly and homogeneously overexpressed on the PC of patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma, MM, and PC leukemia. CD229 was particularly overexpressed on those PC showing an abnormal phenotype such as expression of CD56. Most importantly, CD229 was also highly expressed on those cells in the patients' BM displaying the phenotype of chemotherapy-resistant and myeloma-propagating cells. CD229 Protein, Human, Recombinant (His & Avi) is... | |||
TMPJ-00561 |
SDC2 Protein, Human, Recombinant (His)
CD362,SDC2,HSPG,HSPG1,Syndecan-2,SYND2,Heparan Sulfate Prote... |
Human | HEK293 Cells |
Syndecan-2 is a member of the Syndecans family comprised of type I transmembrane heparan sulfate proteoglycans (HSPG) that are involved in the regulation of many cellular processes. Four sub-types of mammalian Syndecans have been reported and among them. Syndecan-2 plays a role in the cancer development. It can affect the basal and chemotherapy-induced apoptosis in osteosarcoma. It can also suppress MMP2 activation, suppressing metastasis. | |||
TMPK-00407 |
AXL Protein, Human, Recombinant (His & Avi)
AXL oncogene,Axl,EC 2.7.10.1,Tyro7,UFO,ARK,EC 2.7.10,AI32364... |
Human | HEK293 Cells |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi) is e... | |||
TMPK-00472 |
AXL Protein, Cynomolgus, Recombinant (His)
Tyro7,JTK11,AI323647,AXL oncogene,EC 2.7.10.1,EC 2.7.10,UFO,... |
Cynomolgus | HEK293 Cells |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Cynomolgus, Recombinant (His) is ex... | |||
TMPK-00358 |
CD229 Protein, Human, Recombinant (His & Avi), Biotinylated
T100,Lgp100,LY9,AI893573,CD229,SLAMF3 |
Human | HEK293 Cells |
CD229 was strongly and homogeneously overexpressed on the PC of patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma, MM, and PC leukemia. CD229 was particularly overexpressed on those PC showing an abnormal phenotype such as expression of CD56. Most importantly, CD229 was also highly expressed on those cells in the patients' BM displaying the phenotype of chemotherapy-resistant and myeloma-propagating cells. CD229 Protein, Human, Recombinant (His & Avi), B... | |||
TMPY-01118 |
SLC27A4/FATP4 Protein, Human, Recombinant (His)
FATP4,IPS,solute carrier family 27 (fatty acid transporter),... |
Human | HEK293 Cells |
SLC27A4/ATG4B complex might act as a new potential therapeutic target of lung tumor chemotherapy. The solute carrier 27A (SLC27A) gene family encodes fatty acid transport proteins (FATPs) and includes 6 members. Autism spectrum disorders (ASD) are now recognized as disorders caused by impaired early brain development, it is possible that functional abnormalities of SLC27A genes may contribute to the pathogenesis of ASD. The expression of SLC27A3 and SLC27A4 in human neural stem cells derived fro... | |||
TMPY-02398 |
TLE3 Protein, Human, Recombinant (aa 484-772, GST)
transducin-like enhancer of split 3,GRG3,ESG3,HsT18976,ESG |
Human | E. coli |
The association between high TLE3 expression and a favorable response to taxane-containing chemotherapy regimens was validated in patients with non-serous ovarian cancer. That TLE3 expression may serve as a marker of chemosensitivity in taxane-treated patients with non-serous histologies. Transducin-like enhancer of Split3 (TLE3) serves as a transcriptional corepressor during cell differentiation and shows multiple roles in different kinds of cancers. TLE3 repressed CRC proliferation partly thro... | |||
TMPJ-00079 |
IL-11 Protein, Mouse, Recombinant (hFc)
IL-11,Il11,白细胞介素,白介素,Interleukin-11 |
Mouse | HEK293 Cells |
Interleukin-11(IL-11) is a secreted protein and belongs to the IL-6 superfamily. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induceacute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cellproliferation and differentiation and could be use as a therapeutic for osteoporosis. IL-11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thicknes... | |||
TMPY-01865 |
BLMH Protein, Mouse, Recombinant (His)
Bh,bleomycin hydrolase,Bmh,AI035728 |
Mouse | E. coli |
The papain superfamily member bleomycin hydrolase (BLMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. The only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The papain superfamily member bleomycin hydrolase (BLMH) is a neutral cysteine protease with structural similarity to a 20S proteasome. Bleomycin (BLM), a clinically used glycopeptide antica... | |||
TMPY-03748 |
BCL2L12 Protein, Human, Recombinant (GST)
BCL2-like 12 (proline rich) |
Human | E. coli |
BCL2-like 12 (BCL2L12 ) is a new member of the apoptosis-related BCL2 gene family, members of which are implicated in various malignancies. The mRNA expression of BCL2L12 may constitute a novel biomarker for the prediction of short-term relapse in nasopharyngeal carcinoma. BCL2L12 is a recently identified gene belonging to the BCL2 family, members of which are implicated in hematologic malignancies, including chronic lymphocytic leukemia (CLL). BCL2L12 can be considered as a new independent prog... | |||
TMPY-03341 |
ASF1B Protein, Human, Recombinant (His)
anti-silencing function 1B histone chaperone,CIA-II |
Human | Baculovirus Insect Cells |
The histone chaperone anti-silencing factor 1a (ASF1a) interacts with MDC1 and is recruited to sites of DSBs to facilitate the interaction of phospho-ATM with MDC1 and phosphorylation of MDC1, which are required for the recruitment of RNF8/RNF168 histone ubiquitin ligases. Thus, ASF1a deficiency reduces histone ubiquitination at DSBs, decreasing the recruitment of 53BP1, and decreases NHEJ, rendering cells more sensitive to DSBs. This role of ASF1a in DSB repair cannot be provided by the closely... | |||
TMPY-03105 |
Ki67/MKI67 Protein, Human, Recombinant (GST)
MIB-1,PPP1R105,marker of proliferation Ki-67,MIB-,KIA |
Human | E. coli |
MKI67 contains 1 FHA domain and plays a key role in cell proliferation. During interphase, the MKI67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. MKI67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells. MKI67 is an excellent marker to determine the growth fraction of a given cell population. The fraction of MKI67-positive tu... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0499 |
Granisetron-d3
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Granisetron-d3 是 Granisetron 的氘代化合物。Granisetron 的 CAS 号为 109889-09-0。 | |||
TMIJ-0144 |
Palonosetron-d3 HCl
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Palonosetron-d3 HCl 是 Palonosetron HCl 的氘代化合物。Palonosetron HCl 的 CAS 号为 135729-62-3。Palonosetron hydrochloride 是一种 5-HT3 拮抗剂,用于预防和治疗化疗引起的恶心和呕吐。 |