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Cat. No. | Product Name | ||
---|---|---|---|
L8200 | 抗衰老化合物库 | 3279 compounds | |
3279 个抗衰老化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L6120 | 黄酮类天然产物库 | 514 compounds | |
514 种黄酮类天然产物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L6610 | 抗感染天然产物库 | 1060 compounds | |
1060 个抗感染相关的天然产物集合,是药物开发、药理研究的有效工具; | |||
L2195 | 抗前列腺癌化合物库 | 2070 compounds | |
2070 种与前列腺癌相关的化合物,可以用于高通量和高内涵筛选 | |||
L9000 | 细胞凋亡化合物库 | 1760 compounds | |
1760 种与凋亡相关的生物活性小分子化合物的特有集合,多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选; | |||
L1710 | 抗COVID-19化合物库 | 1133 compounds | |
1133 种对SARS-CoV-2有抑制作用或潜在抑制作用的化合物集合,可用于高通量和高内涵筛选; | |||
L6730 | 抗病毒中药单体化合物库 | 268 compounds | |
268 种具有抗病毒活性的中药单体集合,是药物开发、药理研究的有效工具; | |||
L6740 | 抗结直肠癌中药单体化合物库 | 382 compounds | |
382 种抗结直肠癌相关的中药单体集合,是药物开发、药理研究的有效工具; | |||
L6720 | 抗COVID-19中药单体库 | 1147 compounds | |
根据抗新冠肺炎疫情过程中应用于临床治疗的中药方剂,收集了1147 种相关中药来源的单体化合物,可用于高通量和高内涵筛选,是抗新冠病毒药物研发的良好工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6800 |
CCF642
AC1LYELL |
Others | Others |
CCF642 (AC1LYELL) 是蛋白质二硫键异构酶抑制剂(IC50:2.9 μM)。它在多发性骨髓瘤细胞中引起急性内质网应激,并伴随凋亡诱导的钙释放,表现出广泛的抗多发性骨髓瘤作用。 | |||
T8719 |
SC99
|
Apoptosis; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
SC99 是一种口服有效选择性STAT3抑制剂,靶向 JAK2-STAT3 途径,抑制血小板活化和聚集,有抗骨髓瘤和抗血栓活性。它结合在 JAK2 的 ATP 结合袋中,抑制 JAK2 和 STAT3 的磷酸化。 | |||
T3661 |
Citarinostat
ACY241,HDAC-IN-2 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Citarinostat (ACY241) 是一种强效、选择性和口服组蛋白脱乙酰酶 (HDAC) 抑制剂,具有抗肿瘤活性,对 HDAC1、HDAC2、HDAC3、HDAC6 和 HDAC8 的 IC50分别为 35、45、46、2.6 和 137 nM。 | |||
T11141 |
E64FC26
|
Others | Others |
E64FC26 是一种有效的蛋白质二硫键异构酶 (PDI) 家族泛抑制剂,具有抗肿瘤活性,抑制 PDIA1、PDIA3、PDIA4、TXNDC5 和 PDIA6,可用于研究多发性骨髓瘤和胰腺癌。 | |||
T76788 |
Demcizumab
OMP 21M18 |
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
Demcizumab (OMP 21M18) 是一种抗 DLL4 单克隆抗体。Demcizumab 是一种有效的 Notch 通路抑制剂。Demcizumab 在多种癌症模型中无论使单独还联合化疗试剂使用都是有效的。 | |||
T35386 |
Elotuzumab
Elotuzumab (anti-SLAMF7),BMS 901608,PDL 063,HuLuc 63 |
Others | Others |
Elotuzumab(HuLuc 63) (anti-SLAMF7) 是一种靶向 SLAMF7 受体的单克隆抗体。Elotuzumab (anti-SLAMF7) 是一种直接激活NK细胞并诱导抗体依赖性细胞毒性的化合物,可联合来那度胺和地塞米松 (Ld) 用于治疗多发性骨髓瘤。 | |||
T76713 |
Inebilizumab
MEDI 551,MT-0551,16C4-aFuc,VIB-0551 |
Others; ADC Antibody | Antibody-drug Conjugate/ADC Related; Others |
Inebilizumab 是一种人源化抗 CD19 单克隆抗体,对 B 细胞具有增强的抗体依赖细胞介导的细胞毒性。Inebilizumab 可用于治疗多发性硬化和视神经脊髓炎等一些与 CD19的B细胞相关的一系列自身免疫性疾病。 | |||
T0153 |
Oltipraz
吡噻硫酮,NSC 347901,RP 35972 |
HIF/HIF Prolyl-Hydroxylase; HIV Protease; Reverse Transcriptase; Nrf2; HIF | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Oltipraz (RP 35972) 是一种 Nrf2的强效激活剂。它时间依赖性地抑制 HIF-1α激活,IC50为 10 μM,浓度 ≥ 10 μM 时完全消除 HIF-1α诱导。 | |||
T76794 |
Ulocuplumab
BMS 936564,MDX 1338 |
Apoptosis; CXCR | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation |
Ulocuplumab (BMS-936564) 是一种完全人 抗 CXCR4 的 IgG4 抗体。Ulocplumab 在急性髓系白血病 (AML),非霍奇金淋巴瘤 (NHL) 和多发性骨髓瘤移植模型中展现出抗肿瘤活性。Ulocplumab 对 CXCL12 介导的慢性淋巴细胞白血病 (CLL) 细胞在 CXCR4 激活下的迁移有抑制作用,诱导癌细胞凋亡 (apoptosis),。 | |||
T13063 |
T6167923
|
MyD88 | Immunology/Inflammation |
T6167923是一种有效的、选择性的MyD88依赖性信号通路抑制剂。T6167923 与 MyD88 的 Toll/IL1 受体 (TIR) 结构域结合良好,破坏 MyD88 的同二聚体形成。T6167923 抑制 NF-κB 驱动的葡萄球菌肠毒素AP (SEAP) 活性,并且改善抗炎活性,对 IFN-γ,IL-1β,IL-6 和 TNF-α 的 IC50分别为 2.7 μM,2.9 μM,2.66 μM 和 2.66 μM。 | |||
T28805 |
SLM6
NSC-107517,NSC 107517,Sangivamycin-Like Molecule 6,SLM 6,SLM-6 |
Others | Others |
SLM6, an inhibitor of cyclin-dependent kinase-9 (CDK9), exhibits potent anti-multiple myeloma activity. | |||
T24566 |
O-1663
O 1663 |
Others | Others |
O-1663 is an advanced stage breast cancer inhibitor that acts by targeting multiple cannabinoid anti-tumor pathways. | |||
T41070 |
LP-184
|
Others | Others |
LP-184 (Compound 6), referred to as an acylfulvene analog, demonstrates the ability to inhibit tumor growth with noteworthy anti-cancer efficacy observed across multiple cell lines, including ovarian, colon, prostate, and pancreatic. | |||
T16354 |
NSC745885
|
Others | Others |
NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 offers possibilities | |||
T70677 |
PLS-123
|
Others | Others |
PLS-123 is a novel covalent irreversible Btk inhibitor with potential anti-proliferative activity. PLS-123 exhibited more potent anti-proliferative effects than ibrutinib in multiple cellular and in vivo preclinical models of B-cell lineage malignancy, including 14 kinds of cell lines, patients’ primary tumor cells and mouse xenograft model. | |||
T36625 |
LSD1/HDAC6-IN-1
LSD1/HDAC6-IN-1 |
Others | Others |
LSD1/HDAC6-IN-1 is an orally active compound that functions as a dual inhibitor, targeting lysine specific demethylase 1 (LSD1) and histone deacetylase 6 (HDAC6). This compound demonstrates promising anti-tumor activity and is particularly valuable for research focused on multiple myeloma (MM) [1]. | |||
T37815 |
PM226
PM 226 |
Others | Others |
Potent and selective CB2 receptor agonist (Ki = 12.8 nM; EC50 = 38.67 nM). Exhibits negligible affinity for the CB1 receptor (Ki > 40,000 nM) and no activity at the GPR55. Suppresses neuroinflammation by reducing microglial activation in a multiple sclerosis mouse model. BBB permeable; anti-inflammatory and neuroprotective. | |||
T61792 |
HDAC6-IN-10
|
Others | Others |
HDAC6-IN-10 is a potent and specific HDAC6 inhibitor, exhibiting an IC50 value of 0.73 nM. It demonstrates remarkable selectivity towards HDAC6, with a selectivity range of 144 to 10,941-fold over other HDAC isoforms. Furthermore, HDAC6-IN-10 exhibits notable anti-proliferative effects on multiple myeloma cells [1]. | |||
T70838 |
RO27-3225 TFA
|
Others | Others |
RO27-3225, also known as RO273225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. It has been investigated for an anti-obesity medication. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. | |||
T84982 |
GSK3368715 hydrochloride
GSK715 hydrochloride |
Others | Others |
GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth. | |||
T76677 | Dacetuzumab | ||
Dacetuzumab (SGN-40) 是一种人源化的 IgG1,抗 CD40单克隆抗体,具有抗淋巴瘤活性。Dacetuzumab 通过免疫效应作用(抗体依赖性细胞毒性和吞噬作用[ADCC/ADCP]) 杀死肿瘤细胞。Dacetuzumab ((SGN-40) 可用于多发性骨髓瘤研究。 | |||
T15158 |
Dolastatin 15
DLS 15 |
Others; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Others |
Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces cell cycle arrest and apoptosis in m | |||
T69323 |
Dexamethasone sodium succinate
|
Others | Others |
Dexamethasone sodium succinate is the acetate salt form of dexamethasone, which is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. At high doses (e.g. 40 mg), it reduces the immune response. Dexamethasone acetate (NEOFORDEX®) is indicated in adults for the treatment of symptomatic multiple myeloma in combination with other medicinal products. Dexamethasone has been shown to induce multiple myeloma cell death (apoptosis) via a down-regul... | |||
T77091 | Modakafusp alfa | ||
Modakafusp alfa (TAK-573) 是一种融合蛋白,由人源化抗CD38 IgG4 单克隆抗体和2个减毒IFNα2b分子组成。该化合物主要用于多发性骨髓瘤的研究。 | |||
T81580 |
Ozanezumab
GSK1223249 |
||
Ozanezumab (GSK1223249) 是一种anti-Nogo-A 单克隆抗体,用于肌萎缩侧索硬化症 (ALS) 及多发性硬化症研究。 | |||
T36761 |
KRAS inhibitor-10
|
Others | Others |
KRAS inhibitor-10 (WO2021005165 A1, compound 11) is a potent and selective inhibitor of RAS proteins, with a specific focus on KRAS proteins. This orally active anti-cancer agent demonstrates strong efficacy in cancer research, specifically in pancreatic cancer, breast cancer, multiple myeloma, leukemia, and lung cancer. KRAS inhibitor-10 is classified as a tetrahydroisoquinoline compound. Its inhibitory properties provide valuable insights and potential therapeutic applications in the field of ... | |||
T74414 |
S-Allylmercaptocysteine
|
Others | Others |
S-allylmercaptocysteine 是一种从大蒜中提取的有机硫化合物,对各种肺部疾病具有抗炎和抗氧化作用。S-allylmercaptocysteine 通过多种途径发挥抗癌作用,如通过 TGF-β 信号通路诱导癌细胞凋亡 (apoptosis),或通过降低NF-κb 活性和上调 Nrf2 来达到抗炎和抗氧化的作用。 | |||
T61313 |
Antitumor agent-70
|
Others | Others |
Antitumor agent-70 (compound 8b) is a highly potent multi-targeted kinase inhibitor, particularly targeting c-Kit. It demonstrates remarkable anti-tumor activity and the ability to induce cell apoptosis. This compound also exhibits strong inhibition of multiple myeloma, with an IC 50 value of 0.12 μM. Therefore, Antitumor agent-70 holds great potential as an effective therapy for combating cancer, especially in cases involving c-Kit. [1] | |||
T63906 |
hGGPPS-IN-2
|
Others | Others |
hGGPPS-IN-2 是一种 C-2 取代的噻吩并嘧啶基双膦酸盐 (C2-ThP-BPs) 的类似物,是一种有效的人类香叶基香叶基焦磷酸合成酶 (hGGPPS) 抑制剂。hGGPPS-IN-2 能够靶向作用于多发性骨髓瘤 (MM) 细胞,诱导其选择性凋亡 (apoptosis),并在体内显示出抗骨髓瘤作用。 | |||
T77009 | Firivumab | ||
Firivumab (CT-P22; CT120)是一种针对人类IgG1单克隆的抗甲型流感病毒血凝素(Anti-IAV HA)抗体。该抗体能有效中和多种亚型,包括H1N1、H5N1、H6N1、H6N2、H8N4、H8N8、H9N2和H12N7。研究发现,Firivumab在小鼠模型中对H1N1病毒展现出显著的保护效果。 | |||
T73485 |
BT-GSI
|
Others | Others |
BT-GSI 是一种 γ-分泌酶抑制剂 (GSI) 和骨靶向 Notch 抑制剂。BT-GSI 具有双重抗骨髓瘤和抗吸收特性,可用于多发性骨髓瘤及相关骨病的研究。BT-GSI 抑制肿瘤生长和溶骨性疾病进展。 | |||
T76935 | Briakinumab | ||
Briakinumab (ABT-874) 是一种全人抗 IL-12/23p40单克隆抗体。Briakinumab 靶向并中和 IL-12和 IL-23。Briakinumab 可用于类风湿性关节炎、炎症性肠病和多发性硬化症的研究。 | |||
T73693 |
Peginterferon beta-1a
|
Others | Others |
Peginterferon beta-1a (Peginterferon β-1a) 是一个聚乙二醇化干扰素 beta-1a 分子。Peginterferon beta-1a 诱导癌细胞凋亡并且在裸鼠模型中显示出抗肿瘤活性。Peginterferon beta-1a 可用于癌症和多发性硬化 (RMS) 的研究。 | |||
T61673 |
Anticancer agent 56
|
Others | Others |
Anticancer agent 56 (compound 4d) is a powerful anti-cancer compound with favorable drug-like properties. It shows significant anticancer activity against multiple cancer cell lines, with an IC50 value of less than 3 μM. Anticancer agent 56 exerts its effects by causing cell cycle arrest at the G2/M phase and activating the mitochondrial apoptosis pathway. Mechanistically, it induces the accumulation of reactive oxygen species (ROS), upregulates BAX, downregulates Bcl-2, and triggers the activat... | |||
T76729 | Lucatumumab | ||
Lucatumumab (HCD122) 是一种全人抗 CD40拮抗剂单克隆抗体,可阻断 CD40/ CD40L 介导的信号通路。Lucatumumab 可有效介导抗体依赖性细胞介导的细胞毒性 (ADCC) 和肿瘤细胞清除,可用于顽固性淋巴瘤、慢性淋巴细胞白血病 (CLL) 和多发性骨髓瘤研究。 | |||
T79523 |
HDAC6-IN-18
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
HDAC6-IN-18(化合物4)是首个针对HDAC6亚型的不可逆选择性抑制剂,显示出有效的抗多发性骨髓瘤活性。该抑制剂在RPMI8266、U266以及MM.1S细胞系中表现出对HDAC6的抑制效力,其IC50值分别为0.17、0.7和0.42 μM[1]。 | |||
T35747 |
Quinacrine analog 34
|
Others | Others |
Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels ... | |||
T77084 | Mezagitamab | ||
Mezagitamab (TAK-079) 是一种 IgG1λ 类型的抗CD38单克隆抗体。其通过促进抗体和补体依赖性的细胞毒性,来耗尽表达CD38的肿瘤细胞,显示出在复发/难治性多发性骨髓瘤 (RRMM) 及原发性血小板减少性紫癜 (ITP) 等疾病中的治疗潜力。 | |||
T78296 |
IMAB027
ASP1650 |
||
IMAB027 (ASP1650)是针对CLDN6 (Claudin 6)的特异性单克隆抗体,CLDN6作为一种紧密连接蛋白,其在多种人类癌症中异常高表达,尤其显著于卵巢癌。IMAB027展现出抗肿瘤特性,并能诱导表达CLDN6的卵巢癌和睾丸癌细胞走向凋亡。 | |||
T61945 |
hGGPPS-IN-1
|
Others | Others |
hGGPPS-IN-1 是 C-2 取代的噻吩并嘧啶基双膦酸盐 (C2-ThP-BPs) 的类似物,对人类香叶基香叶基焦磷酸合成酶 (hGGPPS) 具有有效的抑制作用。hGGPPS-IN-1 可选择性诱导多发性骨髓瘤 (MM) 细胞凋亡 (apoptosis)。hGGPPS-IN-1在体内表现出抗骨髓瘤活性。 | |||
T85062 |
Anlotinib hydrochloride
|
Others | Others |
Anlotinib is an orally available inhibitor of multiple tyrosine kinases, including human VEGFR1, VEGFR2, VEGFR3, PDGFRβ, and c-Kit with IC50 values of 26.9, 0.2, 0.7, 115, and 14.8 nM, respectively. It demonstrates selectivity for these targets over others like c-Met, c-Src, HER2, and EGFR, which have IC50 values of >2,000 nM. Additionally, anlotinib effectively inhibits FGFR1 with an IC50 of 11.7 nM. Its anti-tumor activity has been confirmed in various cancer cell lines, including colorectal, ... | |||
T62468 |
CB1/2 agonist 1
|
Others | Others |
CB1/2 agonist 1 是一种有效的、能够透过血脑屏障的 CB1/2 激动剂,能够作用于 CB1R (EC50: 56.15 nM) 和 CB2R (EC50: 11.63 nM)。CB1/2 agonist 1 能够降低谷氨酸释放,并减少 LPS 诱导的小胶质细胞活化,具有抗炎和镇痛活性。CB1/2 agonist 1 具有潜力进行多发性硬化症的研究。 | |||
T84443 |
Halofuginone hydrochloride
RU-19110 hydrochloride |
Others | Others |
Halofuginone hydrobromid (RU-19110),Febrifugine的衍生物,作为脯氨酰-tRNA合成酶竞争性抑制剂,其Ki值为18.3 nM。该化合物特异性抑制I型胶原合成,并能通过降低TGF-β活性来减轻骨关节炎症状。同时,Halofuginone hydrobromid作为有效的肺血管扩张剂,通过激活Kv通道并阻断电压门控、受体操作与存储操作的Ca2+通道发挥作用。此外,它还具有抗疟疾、抗炎、抗癌及抗纤维化的多重生物活性。 | |||
T68389 |
LY2457546
|
Others | Others |
LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 (KDR), PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. In vivo, LY2457546 inhibited VEGF-driven autophosphorylation of lung KDR in the mouse and rat in a dose and concentration dependent manner. LY2457546 was well tolerated and exhibited efficacy in a 13762 synge... | |||
T37419 |
Zetomipzomib
|
Others | Others |
KZR-616, a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. KZR-616 has the potential for the research of multiple autoimmune diseases[1][2]. KZR-616 also inhibits MECL-1 subunit (IC50=623 nM) and constitutive proteasome β5 subunit (IC50=688 nM). KZR-616 maintains LMP7 and LMP2 selective inhibition in MOLT-4 cells. KZR-616 (250 nM) shows a comparable cytokine inhib... | |||
T71382 |
KRC-108
|
Others | Others |
KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative activity of KRC-108 was measured by performing a cytotoxicity assay on a panel of cancer cell lines. The GI(50) values (i.e., 50% inhibition of cell growth) for KRC-108 ranged from 0.01 to 4.22 μM for these cancer cell lines. KRC-108 was also effective for the inhibition of tumo... | |||
T61572 |
FNDR-20123 free base
|
Others | Others |
FNDR-20123 free base 是一种有效、安全、首创的抗疟疾HDAC 抑制剂,对疟原虫和人类 HDAC 的IC50分别为 31 nM 和 3 nM。FNDR-20123 free base 对恶性疟原虫 (Plasmodium falciparum) 无性期 (IC50=41 nM) 和性血期 (雄性配子体 IC50=190 nM) 具有抗疟疾活性。FNDR-20123 free base 抑制 HDAC1,HDAC2,HDAC3,HDAC6,HDAC8 的 IC50分别为 25,29,2,11,282 nM,并在纳摩尔浓度下抑制 III 类 HDAC 亚型。 | |||
T38174 |
Mpro inhibitor N3 hemihydrate
|
Others | Others |
Mpro inhibitor N3 hemihydrate is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC50 of 4.0 μM, 8.8 μM, and 2.7 μM, respectively[1][2]. Mpro inhibitor N3 hemihydrate (0-0.64 μM) is able to penetrate cells to inhibit the replication of IBV viruses... | |||
T35802 |
ML-345
|
Others | Others |
Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer's disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2] It de... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2844 |
Hyperoside
Quercetin 3-galactoside,金丝桃甙,金丝桃苷,Hyperin |
Others; Influenza Virus; Antifungal | Microbiology/Virology; Others |
Hyperoside (Hyperin) 是一种从Camptotheca acuminate 提取的黄酮,具有多种生物活性,如心肌保护、抗氧化还原和抗炎活性。 | |||
T5S1026 |
Apigenin-7-glucuronide
Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸 |
MMP | Proteases/Proteasome |
Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) 能够抑制基质金属蛋白酶的活性,其对 MMP-3 (IC50:12.87 μM),MMP-8 (IC50:22.39 μM),MMP-9 (IC50:17.52 μM),MMP-13 (IC50:0.27 μM)。 | |||
TN1543 |
Cynaropicrin
|
HCV Protease; NF-κB; Microtubule Associated | Cytoskeletal Signaling; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Cynaropicrin 是一种存在于朝鲜蓟 (Cynara scolymus) 中倍半萜内酯,具有抗丙型肝炎活性和抗锥虫活性活性,抑制NF-κB活化。 Cynaropicrin 破坏微管蛋白和 c-Myc 相关信号传导,并诱导多发性骨髓瘤中的 parthanatos 型细胞死亡。 | |||
T3752 |
4-Hydroxybenzyl alcohol
4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
4-Hydroxybenzyl alcohol (P-Methylolphenol) 是广泛分布于各种植物中的一种酚类天然产物,具有抗炎、抗氧化和抗伤害感受活性。它抑制肿瘤血管生成和生长,有神经保护作用。 | |||
T3851 |
Vicenin 2
Vicenin -2,维采宁 2,新西兰牡荆苷 |
RAAS | Endocrinology/Hormones |
Vicenin 2 来源于广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂,IC50=43.83 μM。 | |||
T4S1469 |
Cucurbitacin IIb
葫芦素IIB,雪胆素乙 |
Apoptosis; Others | Apoptosis; Others |
Cucurbitacin IIb 是一种雪胆中的活性成分。它阻碍 STAT3,JNK 和 Erk1/2 的磷酸化,提高 IκB 和 NF-κB (p65) 的磷酸化水平,抑制 NF-κB (p65) 的核转位,降低 IκBα 和 TNF-α 的 mRNA 水平。它能够诱导细胞凋亡,具有抗炎作用。 | |||
T3398 |
Icaritin
Anhydroicaritin,去水淫羊藿黄素,Cycloicaritin |
Apoptosis; JAK; STAT; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Icaritin (Anhydroicaritin) 是Epimedium Genusis 的异戊二烯类黄酮衍生物,有效抑制 K562 细胞和原代 CML 细胞的增殖。它可以调节MAPK/ERK/JNK 和JAK2/STAT3/AKT 信号传导,并具有增强成骨的作用。 | |||
T12403 |
Penitrem A
|
Others | Others |
Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies. | |||
TN5369 |
Dehydroleucodine
Dehydroleucodin |
||
Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulat | |||
T78539 |
(+)-Coclaurine hydrochloride
d-Coclaurine hydrochloride,(R)-Coclaurine hydrochloride,(+)-(R)-Coclaurine hydrochloride |
Others | Others |
(+)-Coclaurine ((+)-(R)-Coclaurine) hydrochloride 是从多种植物中分离得到的四氢异喹啉类生物碱,具有抗衰老活性。 | |||
TN4286 |
Isodunnianol
|
NOS; NF-κB; ROS; AChR | Immunology/Inflammation; Neuroscience; NF-κB |
Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the primary cultured rat cortical neurons. Isodunnianol, dunnianol, and Macrant | |||
TN5280 |
(-)-Zeylenol
Zeylenol |
Apoptosis | Apoptosis |
(-)-Zeylenol (Zeylenol) 是一种从 Uvaria grandiflora 的茎中提取的天然产物,具有抗炎、拒食和抗肿瘤生物活性,通过抑制多种炎症介质的合成或释放发挥作用。 zezelenol 对油菜根系生长有抑制作用,具有诱导人乳腺癌 MDA-MB231细胞凋亡的潜力。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02219 |
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)
NS1 Protein |
H1N1 | E. coli |
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast As... | |||
TMPY-03416 |
TNFAIP8 Protein, Human, Recombinant (His)
GG2-1,tumor necrosis factor, alpha-induced protein 8,SCCS2,S... |
Human | E. coli |
Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-alpha inducible anti-apoptotic protein with multiple roles in tumor growth and survival. by the creation of cellular autophagy events, TNFAIP8 promotes cell survival and drug resistance in prostate cancer cells. TNFAIP8 regulates Hippo pathway through interacting with LATS1 to prom... | |||
TMPJ-00948 |
Endostatin Protein, Mouse, Recombinant (His)
antiangiogenic agent,type XVIII,collagen α-1(XVIII)... |
Mouse | HEK293 Cells |
Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti‑endothelial and anti‑tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse End... | |||
TMPJ-00130 |
SLAMF2 Protein, Human, Recombinant (hFc & His)
Leukocyte antigen MEM-102,CD48 antigen,CD4... |
Human | HEK293 Cells |
CD48 antigen, also known as B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, TCT.1, CD48, BCM1,and BLAST1, CD48 contains one Ig-like C2-type domain and one Ig-like V-type domain, but does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. CD48 may facilitate interaction between activated lymphocytes and be involved in regulating T-cel... | |||
TMPH-00672 |
Metalloprotease stcE Protein, E. coli O157:H7, Recombinant (His)
stcE,Neutral zinc metalloprotease StcE,Metalloprotease StcE,... |
E. coli | E. coli |
Virulence factor that contributes to intimate adherence of enterohemorrhagic E.coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves human C1 inhibitor (SERPING1), a regulator of multiple inflammatory pathways, and binds and localizes it to bacterial and host cell surfaces, protecting them from complement-mediated lysis. Therefore, the current model proposes two roles for StcE during infection: it acts first as... | |||
TMPY-02597 |
IL-37 Protein, Human, Recombinant
FIL1Z,IL-37,白细胞介素,IL37,IL1F7,IL-1RP1,FIL1(ζ),IL1RP1,FIL1,白介素... |
Human | E. coli |
Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7 may be involved in immune response, inflammatory diseases, and/or cancer. Through constructing an adenoviral vector that allows high-level expression i... | |||
TMPY-01824 |
Caspase-14 Protein, Human, Recombinant (His)
caspase 14, apoptosis-related cysteine peptidase,ARCI12 |
Human | E. coli |
Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Casp... | |||
TMPY-05252 |
Myeloperoxidase/MPO Protein, Human, Recombinant (His)
myeloperoxidase |
Human | HEK293 Cells |
MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. Myeloperoxidase (MPO) is an important enzyme, which is one of the components of the antibacterial system in neutrophils and monocytes. MPO participates in the inflammatory response in multiple locations in the body, including the mammary glands. Myeloperoxidase (MPO), a specific polymorphonuclear leukocyte enzyme, has ... | |||
TMPY-04554 |
JNK1 Protein, Human, Recombinant (GST)
PRKM8,JNK,JNK-46,JNK21B1/2,JNK1A2,mitogen-activated protein ... |
Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. The protein kinases JNK1 has been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. It is critically involved in ... | |||
TMPH-02317 |
YTHDF1 Protein, Human, Recombinant (His)
YTHDF1,Dermatomyositis associated with cancer putative auto<... |
Human | P. pastoris (Yeast) |
Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradatio... | |||
TMPY-04550 |
JNK2 Protein, Human, Recombinant (His)
JNK2α,SAPK1a,PRKM9,JNK2β,JNK2,SAPK,JNK2BETA,mitogen-activate... |
Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating some transcription factors, such as c-Jun and ATF2. The crystal structure of human JNK2 complexed with an indazole inhibitor by applying a high-throughput protein engineering and surface-site mutagenesis approach. A n... | |||
TMPH-01503 |
Humanin Protein, Human, Recombinant (hFc)
MT-RNR2,Humanin,Humanin mitochondrial |
Human | HEK293 Cells |
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation.... | |||
TMPH-01502 |
Humanin Protein, Human, Recombinant (GST)
Humanin,Humanin mitochondrial,MT-RNR2 |
Human | E. coli |
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation.... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMID-0006 |
Budesonide-d8
mixture of diastereomers-d8 |
||
Budesonide-d8 是 Budesonide 的氘代化合物。Budesonide 的 CAS 号为 51333-22-3。Budesonide 是吸入型糖皮质类固醇,是一种口服具有活性的糖皮质激素受体激动剂。它能够减小肺部肿瘤的体积,逆转 DNA 低度甲基化,调节基因的 mRNA 表达。它是能够用于哮喘的抗炎药。 |