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Search Results for " lung injury "

Targets Recommended: Others

54

抑制剂 & 化合物

22

天然产物

9

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8313	HCH6-1	Others	Others
	HCH6-1 是甲酰肽受体 1 的竞争性二肽拮抗剂。它能够抑制 fMLF (FPR1激动剂) 特异性激活的人中性粒细胞的趋化性、超氧阴离子生成和弹性酶释放。动物实验中，它对急性肺损伤具有保护作用，可用于研究 FPR1 参与的炎症性肺部疾病。
T40423	L48H37	Others	Others
	L48H37是Curcumin的一个化学稳定类似物。它对髓系分化蛋白2 (MD2) 表现出强效的抑制性质，作为一个特异性抑制剂。其机制包括抑制LPS-TLR4/MD2的相互作用和信号传导。L48H37主要用于脓血症和肺损伤研究[1]。
T6986	Sivelestat ONO5046,EI546,西维来司他,LY544349	Others; SARS-CoV; Serine Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Sivelestat (ONO5046) 是一种选择性的中性粒细胞弹性蛋白酶抑制剂，其 IC50值为 44 nM，Ki 值为 200 nM。它有潜力研究 COVID-19 的急性肺损伤、急性呼吸窘迫综合征或弥散性血管内凝血。
T2663	GTS-21 dihydrochloride GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine	5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	GTS-21 dihydrochloride (DMBX-anabaseine) 是一种选择性 α7 烟碱乙酰胆碱受体激动剂，具有抗炎和增强认知的活性。它也是一种拮抗剂，对人α4β2的 Ki 为20 nM，对5-HT3A 受体的 IC50为3.1 μM。
TP1016L	Aviptadil Acetate 醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt	RAAS; SARS-CoV	Endocrinology/Hormones; Microbiology/Virology
	Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) 是模拟血管活性肠多肽类似物，具有血管舒张效应。它可诱导肺血管舒张并抑制血管 SMC 的增殖和血小板聚集。它可用于研究 SARS-CoV-2 引起的肺纤维化、肺动脉高压和呼吸衰竭。
T40612	Manganese(salen) chloride EUK-8	Others	Others
	Manganese(salen) chloride (EUK-8) 是超氧化物歧化酶和过氧化氢酶的一种模拟物，具有氧自由基清除性能。它可减轻内毒素血症猪的急性肺损伤。
T77582	Anti-inflammatory agent 51	NF-κB	NF-κB
	Anti-inflammatory agent 51 是一种具有抗炎活性和潜在抗肿瘤活性的酰胺/磺酰胺衍生物，对 NF-κB 激活有抑制作用，可用于研究急性肺损伤和溃疡性结肠炎。
T38404	MJ33 lithium salt	ROS	Immunology/Inflammation
	MJ33 lithium salt 是 NADPH 氧化酶 2 型介导的 ROS 生成抑制剂，是一种氟化磷脂类似物，可抑制过氧化物还蛋白 6 （Prdx6）的磷脂酶 A2 （PLA2）活性，可用于研究急性肺损伤。
T39719	Nrf2 activator-1 Nrf2 activator-1	Nrf2	Immunology/Inflammation
	Nrf2 activator-1 是一种有效的 NF-E2 相关因子 2 (Nrf2) 激活剂。Nrf2 activator-1 可用于研究包括哮喘、急性肺损伤 (ALI)、急性呼吸窘迫综合征 (ARDS) 和肺纤维化等 COPD 和其他呼吸系统疾病。
T38227	Quin C1	Others	Others
	Quin C1 是一种具有选择性和高效性的甲酰肽受体 2 (FPR2/ALX) 激动剂，具有抗炎活性，抑制BALF 中的中性粒细胞和淋巴细胞的产生，减少 TNF-α、IL-1β、KC 和 TGF-β1 的表达。Quin C1 可用于研究肺损伤。
T76840	Vunakizumab Anti-Human IL17A Recombinant Antibody	IL Receptor	Immunology/Inflammation
	Vunakizumab 是一种靶向 IL-17A 的人源化 IgGκ 单克隆抗体，常与白细胞介素 22 链接形成 Vunakizumab-IL22 来研究流感病毒引起的肺免疫损伤。Vunakizumab 可用于研究银屑病关节炎，通过与IL-17A结合发挥作用。
T21493	Cyclosporin H	Others	Others
	Cyclosporin H 是一种 FPR-1(甲酰肽受体 1) 的选择性强效抑制剂。它缺乏 Cyclosporin A 具有的免疫抑制活性。它是一种病毒转导增强剂，可使人脐带血来源的造血干细胞和祖细胞中慢病毒转导增强 10 倍。它与雷帕霉素或前列腺素 E2 联合使用时表现出累加效应。
T20762	Sivelestat sodium tetrahydrate ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046	Serine Protease	Proteases/Proteasome
	Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂，其 IC50 值为 44 nM， Ki 值为 200 nM。Sivelestat (EI546) sodium tetrahydrate 有潜力用于 COVID-19的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。
T0189L	Pemetrexed disodium 培美曲塞二钠盐,LY-231514,LY231514 disodium,培美曲塞二钠,Pemetrexed	Apoptosis; DHFR; DNA/RNA Synthesis; Antifolate; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Pemetrexed disodium (LY-231514) 是一种叶酸拮抗剂，用于治疗非小细胞肺癌和恶性间皮瘤。它抑制胸苷酸合成酶，二氢叶酸还原酶和甘氨酰胺核苷酸甲酰转移酶的Ki 分别为 1.3 nM，7.2 nM 和 65 nM。
T60437	PNU-282987 free base	5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	PNU-282987 free base 是一种具有选择性和高效性的 α7 烟碱乙酰胆碱受体 (nAChR) 激动剂，也是5-HT3受体的拮抗剂，具有抗炎活性，对脓毒症诱导的小鼠急性肺损伤有保护作用，可减弱 ILC2s 活化和链格孢菌诱导的气道炎症。PNU-282987 free base 可用于研究神经系统疾病。
T11518L	GW274150	NOS	Immunology/Inflammation
	GW274150 是一种具有口服活性，选择性和高效性的 NADPH 依赖型人一氧化氮合成酶 (iNOS) (Kd=40 nM) 和大鼠诱导型一氧化氮合酶 (iNOS) 双重抑制剂。GW274150 对人和大鼠的内皮一氧化氮合酶 (eNOS) 和神经元一氧化氮合酶 (nNOS) 活性较低。在急性肺损伤炎症模型中，GW274150 表现出保护作用。
T70874	Vipoglanstat	Others	Others
	Vipoglanstat is a prostaglandin E synthase inhibitor and an anti-inflammatory. Vipoglanstat ameliorates leukocyte infiltration and lung injury resulting from both endotoxin-induced and sepsis-induced lung injury.
T15354	FTY720 (S)-Phosphate (S)-FTY720 phosphate,(S)-FTY720P	Others	Others
	FTY720 (S)-Phosphate is an S1P receptor 1 (S1PR1) agonist. It is used in the research of acute inflammatory diseases such as acute lung injury.
T63709	Nezulcitinib	Others	Others
	Nezulcitinib (TD-0903) 是一种吸入的、肺选择性的 pan-Janus kinase (JAK) 抑制剂，能够用于研究 COVID-19 相关急性肺损伤及氧合受损。
TP1373	Ac2-26
	Ac2-26 TFA is an active n-terminal peptide in annexin A1 (AnxA1), which can alleviate acute lung injury caused by ischemia-reperfusion.
TP1321	Ac2-26 TFA (151988-33-9 free base) Ac2-26 TFA
	Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue.
T28247	ONO-1714 HCl ONO-1714,ONO1714,ONO-1714 hydrochloride,ONO 1714	Others	Others
	ONO-1714 is a inducible nitric oxide synthase (NOS-2) inhibitor. ONO-1714 reduces hyperoxic lung injury in mice. ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice. ONO-1714 also inhibits neuronal NOS and exerts an
T70145	LYRM03	Others	Others
	LYRM03 is an aminopeptidase inhibitor. LYRM03 is also an ubenimex derivative. LYRM03 attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway. LYRM03 effectively attenuates LPS-induced ALI by inhibiting the expression of pro-inflammatory mediators and Myd88-dependent TLR4 signaling pathways in alveolar macrophages. LYRM03 may serve as a potential treatment for sepsis-mediated lung injuries.
T75800	Ac2-26 TFA
	Ac2-26 TFA，是膜联蛋白 A1 (AnxA1) 的活性 N-末端肽，可减轻缺血再灌注诱导的急性肺损伤。Ac2-26 还降低 AnxA1 蛋白表达，抑制受损肺组织中NF-κB 和 MAPK 通路活化。
T78091	(S)-FTY720-phosphonate	LPL Receptor	GPCR/G Protein
	FTY720 (S)-Phosphate，作为S1P受体1 (S1PR1) 激动剂，可用于研究急性肺损伤等急性炎症。
T35921	N-Oleoyl Valine
	N-Oleoyl valine is an endogenous N-acyl amine that acts as an antagonist at the transient receptor potential vanilloid type 3 (TRPV3) receptor, which is involved in thermoregulation. N-Oleoyl valine is increased in mice following cold exposure for up to at least 16 days. Acute lung injury in mice increases the concentration of N-Oleoyl valine in lung tissue. N-acyl amines also promote mitochondrial uncoupling.
TP1373L	Ac2-26 acetate	NF-κB	NF-κB
	Ac2-26 acetate 是一种膜联蛋白 A1(AnxA1) 的活性 N 末端肽。 Ac2-26 acetate 降低 AnxA1 蛋白表达并抑制受损肺组织中 NF-κB 和 MAPK 通路的激活。 Ac2-26 acetate 可减轻缺血再灌注诱导的急性肺损伤。
T74832	TRPV4 antagonist 4	Others	Others
	TRPV4 antagonist 4 是一种有效的 TRPV4拮抗剂，IC50值为 22.65 nM。TRPV4 antagonist 4 抑制 TRPV4 电流。TRPV4 antagonist 4 显示出对急性肺损伤的保护作用。
T61302	Anti-inflammatory agent 17	Others	Others
	Anti-inflammatory agent 17 an orally active anti-inflammatory agent, demonstrates potent efficacy in inhibiting the release of IL-6 and TNF-α without causing cytotoxicity in in vitro experiments. Furthermore, in vivo studies confirm its anti-inflammatory activity. Given its attributes, Compound 17 holds promise for investigating Acute lung injury (ALI) [1].
T78882	NF-κB-IN-12	NF-κB	NF-κB
	NF-κB-IN-12 (compound 3h)，作为一种NF-κB抑制剂，在急性肺损伤研究中具有应用潜力，其IC50值为1.02 μM。
T82464	eNOS pT495 decoy peptide
	eNOSpT495 decoy peptide是一种特异性肽，旨在阻止T495磷酸化从而减少eNOS解偶联和线粒体再分布，该肽常用于研究呼吸机诱导的肺损伤。
T80954	TREM-1 inhibitory peptide M3
	TREM-1 inhibitory peptide M3为一种配体依赖的TREM-1拮抗剂。该化合物能够有效抑制全身及肺部促炎细胞因子与趋化因子的产生，有助于缓解急性肺损伤。
T63261	iNOs-IN-3	Others	Others
	iNOs-IN-3 是口服具有活力的一氧化氮合成酶 (iNOS) 抑制剂，IC50 值为 3.342 μM，表现出抗炎作用，能够用于研究 LPS 诱导的急性肺损伤 (ALI) 。
T76767	Daxdilimab
	Daxdilimab 是一种 anti-ILT7单克隆抗体，ILT7 是 pDC 型树突状细胞特有的细胞表面分子。Daxdilimab 可用于 COVID-19 感染的急性肺损伤 (ALI) 的研究。
T36623	Antileukinate
	Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 μM), prevents neutrophil chemotaxis and β-glucuronidase release, and blocks IL-8-induced skin edema in rabbits. At 53 mg/kg, antileukinate has been shown to protect mice against acute pancreatitis and associated lung injury.
T38047	Maresin 1	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Maresin 1 是由巨噬细胞 (MΦ) 生物合成的小分子化合物，具有显著的抗炎活性，可通过抑制中性粒细胞粘附和降低促炎细胞因子水平来减轻LPS诱导的小鼠肺损伤，可以刺激胞内 Ca2+ 产生和分泌。
T79585	Anti-inflammatory agent 50	NF-κB	NF-κB
	Anti-inflammatory agent 50 (compound a1)是Fusidic acid的衍生物，有效抑制NO、IL-6及TNF-α等炎症因子，调控炎症介质及抑制MAPK、NF-κB和NLRP3炎症小体信号通路，从而减轻急性肺损伤。
T63761	ACT-660602	Others	Others
	ACT-660602 是口服具有活力的趋化因子受体 CXCR3 拮抗剂 (IC50: 204 nM)。ACT-660602 能够抑制 T 细胞迁移，并在体内急性肺损伤模型中显示出显著作用。ACT-660602 能够用于研究自身免疫性疾病。
T68788	Ellipticine quinone	Others	Others
	Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.). Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mi...
T73382	SZM-1209	RIP kinase	Apoptosis; NF-κB
	SZM-1209是一种口服活性且特异性RIPK1抑制剂，具有85 nM的Kd值。该化合物展现出对抗坏死性凋亡（necroptosis）高效活性（EC50=22.4 ± 8.1 nM），并能抵抗SIRS（全身炎症反应综合征）及ALI（急性肺损伤）。
T69230	AZD-1236	Others	Others
	AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg, and also abolished ...
T85063	GHK-Cu acetate Gly-His-Lys-Cu(II)	Others	Others
	GHK-Cu acetate, a complex of the tripeptide Gly-His-Lys and a copper(II) ion, exhibits wound healing and anti-inflammatory properties. It enhances fibroblast proliferation, collagen production, and the release of pro-matrix metalloproteinase-2 (MMP-2) and glycosaminoglycans (GAGs), while also increasing decorin expression in rat wound tissue. Furthermore, at a concentration of 10 µM, it reduces levels of reactive oxygen species (ROS), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α)...
T74799	NF-κB-IN-8	NF-κB	NF-κB
	NF-κB-IN-8 是一种化合物，其作用机制为竞争性抑制 LPS 与 MD-2 之间的相互作用。该化合物通过与 MD-2 结合，有效降低炎症因子的产生，并能够抑制 ALP 的酶活性。因此，NF-κB-IN-8 在急性肺损伤（ALI）等炎症性疾病的研究中具有潜在应用价值。
T78113	Tylvalosin Acetylisovaleryltylosin	Antibiotic	Microbiology/Virology
	Tylvalosin (Acetylisovaleryltylosin) 是一种具有抗菌和抗病毒特性的广谱大环内酯抗生素。它能够诱导细胞凋亡(apoptosis)、展现抗炎效果、缓解氧化应激，并通过抑制NF-κB的激活减轻急性肺损伤。此外，Tylvalosin 在研究PRRSV感染方面作为抗病毒试剂亦被应用。
T82272	Gol-NTR
	Gol-NTR是一种针对高尔基体的选择性和灵敏度极高的探针，由硝基还原酶(NTR)激活，用于可视化急性肺损伤(ALI)及其修复。该探针的检测限低至54.8 ng/mL，适用于监测和评估脓毒症引发的ALI反应。
T78371	Ac2-26 ammonium
	Ac2-26 ammonium是一种具抗炎作用的annexin 1 N末端肽。该化合物能够通过伴侣介导的自噬(CMA)机制降低溶酶体中的IKKβ蛋白含量，从而改善肺缺血再灌注损伤，并在哮喘大鼠模型中抑制气道炎症以及高反应性的表现。
T78829	JNK2-IN-1	JNK	MAPK
	JNK2-IN-1（Compound J27）是一款具有抗炎活性的JNK2抑制剂，其解离常数为79.2 μM。该化合物能通过阻断NF-κB/MAPK信号通路来降低肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6）的释放，从而减轻脂多糖（LPS）引起的急性肺损伤（ALI）及脓毒症症状。
T36714	Sucrose octasulfate (potassium salt)	Others	Others
	Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. It can bind to exosite II of thrombin (KD = ~1.4 μM) and inhibit its catalytic activity (IC50 = 4.5 μM) and, as such, has been used as a surrogate for heparin. Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by pr...
T76990	Suvratoxumab
	Suvratoxumab (MEDI4893) 是一种长效且具有亲和力高的人源化抗 α-毒素单克隆抗体(IgG1κ 型)。Suvratoxumab 能有效中和 α-毒素 (一种关键的金黄色葡萄球菌毒力因子)。Suvratoxumab 可提高免疫功能低下的小鼠肺炎模型的存活率并减少肺损伤。Suvratoxumab 还可增强Vancomycin 或Linezolid 的抗菌活性。
T79658	PI3Kδ-IN-14	PI3K	PI3K/Akt/mTOR signaling
	PI3Kδ-IN-14（化合物（S）-29）是一种高选择性PI3Kδ抑制剂，具有出色的靶点亲和力（IC50为0.8 nM，Kd为84.8 nM）。该化合物特异性结合至PI3Kδ激酶的ATP结合位点，并通过抑制PI3K/AKT信号通路发挥抗炎作用。此外，PI3Kδ-IN-14在改善急性肺损伤（ALI）方面显示出潜在效果。

化合物

Cat.No: T8313

Target: Others

Cat.No: T40423

Target: Others

Cat.No: T6986

Synonym: ONO5046,EI546,西维来司他,LY544349

Target: Others, SARS-CoV, Serine Protease

GTS-21 dihydrochloride

Cat.No: T2663

Synonym: GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine

Target: 5-HT Receptor, AChR

Aviptadil Acetate

Cat.No: TP1016L

Synonym: 醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt

Target: RAAS, SARS-CoV

Manganese(salen) chloride

Cat.No: T40612

Synonym: EUK-8

Target: Others

Anti-inflammatory agent 51

Cat.No: T77582

Target: NF-κB

MJ33 lithium salt

Cat.No: T38404

Target: ROS

Nrf2 activator-1

Cat.No: T39719

Synonym: Nrf2 activator-1

Target: Nrf2

Cat.No: T38227

Target: Others

Cat.No: T76840

Synonym: Anti-Human IL17A Recombinant Antibody

Target: IL Receptor

Cat.No: T21493

Target: Others

Sivelestat sodium tetrahydrate

Cat.No: T20762

Synonym: ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046

Target: Serine Protease

Pemetrexed disodium

Cat.No: T0189L

Synonym: 培美曲塞二钠盐,LY-231514,LY231514 disodium,培美曲塞二钠,Pemetrexed

Target: Apoptosis, DHFR, DNA/RNA Synthesis, Antifolate, Autophagy

PNU-282987 free base

Cat.No: T60437

Target: 5-HT Receptor, AChR

Cat.No: T11518L

Target: NOS

Cat.No: T70874

Target: Others

FTY720 (S)-Phosphate

Cat.No: T15354

Synonym: (S)-FTY720 phosphate,(S)-FTY720P

Target: Others

Cat.No: T63709

Target: Others

Cat.No: TP1373

Ac2-26 TFA (151988-33-9 free base)

Cat.No: TP1321

Synonym: Ac2-26 TFA

Cat.No: T28247

Synonym: ONO-1714,ONO1714,ONO-1714 hydrochloride,ONO 1714

Target: Others

Cat.No: T70145

Target: Others

Cat.No: T75800

(S)-FTY720-phosphonate

Cat.No: T78091

Target: LPL Receptor

N-Oleoyl Valine

Cat.No: T35921

Cat.No: TP1373L

Target: NF-κB

TRPV4 antagonist 4

Cat.No: T74832

Target: Others

Anti-inflammatory agent 17

Cat.No: T61302

Target: Others

Cat.No: T78882

Target: NF-κB

eNOS pT495 decoy peptide

Cat.No: T82464

TREM-1 inhibitory peptide M3

Cat.No: T80954

Cat.No: T63261

Target: Others

Cat.No: T76767

Cat.No: T36623

Cat.No: T38047

Target: Calcium Channel

Anti-inflammatory agent 50

Cat.No: T79585

Target: NF-κB

Cat.No: T63761

Target: Others

Ellipticine quinone

Cat.No: T68788

Target: Others

Cat.No: T73382

Target: RIP kinase

Cat.No: T69230

Target: Others

Cat.No: T85063

Synonym: Gly-His-Lys-Cu(II)

Target: Others

Cat.No: T74799

Target: NF-κB

Cat.No: T78113

Synonym: Acetylisovaleryltylosin

Target: Antibiotic

Cat.No: T82272

Ac2-26 ammonium

Cat.No: T78371

Cat.No: T78829

Target: JNK

Sucrose octasulfate (potassium salt)

Cat.No: T36714

Target: Others

Cat.No: T76990

Cat.No: T79658

Target: PI3K

Cat. No.	Product Name	Target	Signaling Pathways
T0610	Piceatannol 白皮杉醇,trans-Piceatannol,Astringenin	Apoptosis; Serine/threonin kinase; PKA; Syk; PKC; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Tyrosine Kinase/Adaptors
	Piceatannol (Astringenin) 是一种Syk 抑制剂，可降低由 TNF 诱导的 iNOS 表达，可研究急性肺损伤。它是存在于各种水果和蔬菜中天然存在的多酚二苯乙烯，可诱导细胞自噬和凋亡，具有抗癌和抗炎特性。
T3409	Plantamajoside Y0160,C10485,大车前苷,车前子甙	Others	Others
	Plantamajoside (Y0160) 是一种苯丙烷类糖苷，从车前Plantago asiaticaL.中分离出来得到。它对 LPS 诱导的急性肺损伤小鼠模型具有保护作用。它对肺部炎症具有潜在的研究价值。
T2870	Matrine Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine	Mitophagy; Ferroptosis; Opioid Receptor; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Matrine (Vegard) 是一种从槐属植物中分离出来的生物碱，可作为一种κ阿片受体激动剂，有抗肿瘤活性。
T6S0105	Peiminine 贝母素乙,Zhebeinone,Fritillarine,Raddeanine,Verticinone	Others; Autophagy	Autophagy; Others
	Peiminine (Raddeanine) 是浙贝母中的一种生物碱，具有抗炎症活性。
T5798	Euphorbia Factor L2 千金子素L2,euphorbiafactor L2,大戟因子L2	Apoptosis; NF-κB	Apoptosis; NF-κB
	Euphorbia Factor L2 是从大戟种子中分离得到的一种赤藓烷二萜，显示强烈的细胞毒性并通过线粒体途径诱导细胞凋亡，具有抗癌活性。
T4S1422	Praeruptorin E 白花前胡素 E,白花前胡素E	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Praeruptorin E 是白花前胡中的一种主要成分，是钙拮抗剂，pD2′值为 5.2。
T3S0401	Piceatannol 3'-O-glucoside 白皮杉醇 3'-O-葡萄糖苷,Piceatannol 3-glycoside,Quzhaqigan,曲札茋苷、白皮杉醇-3'-O-葡萄糖苷	Arginase; NO Synthase	Immunology/Inflammation
	Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) 是大黄的一种活性成分，通过抑制精氨酸酶活性激活内皮细胞一氧化氮合酶，抑制Arginase I 和Arginase II，IC50值分别为 11.22 和 11.06 μM。它可增加肺血氧分压，减少肺间质水肿，从而保护肺损伤。
T3676	Sesamol 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Sesamol (1,3-Benzodioxol-5-ol) 是芝麻油的主要成分，具有抗氧化和抗肿瘤活性。它是一种自由基清除剂，在 DPPH 实验中，IC50为 5.95±0.56 μg/mL。
TN1936	Mogroside III-E 罗汉果皂苷ⅢE	IL Receptor; TNF; TLR	Apoptosis; Immunology/Inflammation
	Mogroside IIIe 是一种葫芦烷型化合物，从罗汉果中分离得到，可抑制 NO 的释放，具有抗肺纤维化作用。
T3902	Atractylenolide III 白术内酯 III,ICodonolactone,8β-Hydroxyasterolide	Apoptosis	Apoptosis
	Atractylenolide III (ICodonolactone) 是白术根茎主要成分，通过诱导细胞色素 c 的释放、上调 Bax 的表达和易位凋亡诱导因子，是治疗人肺癌的潜力。
T5S0106	Peimisine 贝母辛,Ebeiensine	RAAS; AChR	Endocrinology/Hormones; Neuroscience
	Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体，抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放，促进一氧化氮释放，可舒张气管平滑肌，有平喘作用。
T6S1256	Ruscogenin	NOS; NF-κB; NOD-like Receptor (NLR)	Immunology/Inflammation; NF-κB
	Ruscogenin 是一种重要甾体皂苷元，提取自麦冬。它能够抑制 TXNIP/NLRP3炎症体激活和 MAPK 途径，改善脑缺血诱导的血脑屏障功能障碍，具有显著抗血栓、抗炎作用。
T2854	Phillyrin Forsythin,连翘苷	P450; Influenza Virus; AMPK	Chromatin/Epigenetic; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Phillyrin (Forsythin) 是从连翘中分离出来的一种天然产物，具有抗甲型流感病毒的活性，以及抗菌和消炎作用。
T2S2264	Linalool Linalol,(±)-Linalool,Phantol,沉香醇	Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物，是竞争性NMDA 受体拮抗剂，具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤，具有镇痛、抗菌和抗炎的特性。
T6S1572	Sauchinone	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS，TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。
TN2063	Physalin B NSC-287088	Apoptosis; NF-κB; Akt; PI3K; Nrf2; NOD	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Physalin B 是茄科植物的主要活性化合物之一，具有广泛的生物活性，可用于治疗炎症湿疹和疱疹等疾病。Physalin B 通过激活 PI3K/Akt 通路抑制 NF-κB 和 NLRP3，从而改善脂多糖诱导的急性肺损伤造成的炎症反应。Physalin B 通过激活 Nrf2 通路抑制 PDGF-BB 诱导的 VSMC 增殖、迁移和表型转化。Physalin B 通过抑制 LAP2α-HDAC1 介导的胶质瘤相关癌基因 1 的去乙酰化和肝星状细胞活化来发挥抗肿瘤活性。
T19782	Antidesmone	Others	Others
	Antidesmone is one compound mainly isolated from Ajugade cumbers Thunb (Labiatae). Antidesmone prevents acute lung injury via regulating MAPK and NF-κB activities.
T5S0313	Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside Liquiritin apioside,甘草苷元-7-O-D-芹糖-4'-O-D-葡萄糖苷	Others; TNF	Apoptosis; Others
	Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress, might be as protective agent against epithelial
T79970	Taxamairin B	Others	Others
	Taxamairin B是有效的抗炎化合物，能显著抑制LPS诱导的RAW264.7细胞中促炎因子(TNF-α, IL-1β和IL-6)表达及NO、ROS生成，并对LPS引起的急性肺损伤模型小鼠具有保护效果。
TN4490	Manassantin B	ERK; BCL; p38 MAPK; TNF; NF-κB; JNK; STAT; Antifection	Apoptosis; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells
	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in pa...
TN2534	1-Hydroxy-2,3,5-trimethoxyxanthone	IκB/IKK; Calcium Channel; NOS; 5-HT Receptor; COX	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-c...
T35624	Ajoene	Others	Others
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Cat.No: T0610

Synonym: 白皮杉醇,trans-Piceatannol,Astringenin

Target: Apoptosis, Serine/threonin kinase, PKA, Syk, PKC, Autophagy

Cat.No: T3409

Synonym: Y0160,C10485,大车前苷,车前子甙

Target: Others

Cat.No: T2870

Synonym: Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine

Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy

Cat.No: T6S0105

Synonym: 贝母素乙,Zhebeinone,Fritillarine,Raddeanine,Verticinone

Target: Others, Autophagy

Euphorbia Factor L2

Cat.No: T5798

Synonym: 千金子素L2,euphorbiafactor L2,大戟因子L2

Target: Apoptosis, NF-κB

Cat.No: T4S1422

Synonym: 白花前胡素 E,白花前胡素E

Target: Others, Calcium Channel

Piceatannol 3'-O-glucoside

Cat.No: T3S0401

Synonym: 白皮杉醇 3'-O-葡萄糖苷,Piceatannol 3-glycoside,Quzhaqigan,曲札茋苷、白皮杉醇-3'-O-葡萄糖苷

Target: Arginase, NO Synthase

Cat.No: T3676

Synonym: 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚

Target: Apoptosis, AMPK

Mogroside III-E

Cat.No: TN1936

Synonym: 罗汉果皂苷ⅢE

Target: IL Receptor, TNF, TLR

Atractylenolide III

Cat.No: T3902

Synonym: 白术内酯 III,ICodonolactone,8β-Hydroxyasterolide

Target: Apoptosis

Cat.No: T5S0106

Synonym: 贝母辛,Ebeiensine

Target: RAAS, AChR

Cat.No: T6S1256

Target: NOS, NF-κB, NOD-like Receptor (NLR)

Cat.No: T2854

Synonym: Forsythin,连翘苷

Target: P450, Influenza Virus, AMPK

Cat.No: T2S2264

Synonym: Linalol,(±)-Linalool,Phantol,沉香醇

Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR

Cat.No: T6S1572

Target: ERK, p38 MAPK, NF-κB

Cat.No: TN2063

Synonym: NSC-287088

Target: Apoptosis, NF-κB, Akt, PI3K, Nrf2, NOD

Cat.No: T19782

Target: Others

Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside

Cat.No: T5S0313

Synonym: Liquiritin apioside,甘草苷元-7-O-D-芹糖-4'-O-D-葡萄糖苷

Target: Others, TNF

Cat.No: T79970

Target: Others

Cat.No: TN4490

Target: ERK, BCL, p38 MAPK, TNF, NF-κB, JNK, STAT, Antifection

1-Hydroxy-2,3,5-trimethoxyxanthone

Cat.No: TN2534

Target: IκB/IKK, Calcium Channel, NOS, 5-HT Receptor, COX

Cat.No: T35624

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02028	RON/CD136 Protein, Human, Recombinant (His) CD136,macrophage stimulating 1 receptor,CDw136,PTK8,RON	Human	HEK293 Cells
	The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in...
TMPY-02869	MMP-12 Protein, Human, Recombinant (catalytic domain) HME,ME,MMP-12,MME,matrix metallopeptidase 12	Human	E. coli
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ...
TMPK-00096	FGF-10 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated FGF-10,KGF2	Human	E. coli
	Fibroblast growth factor 10 (FGF10) regulates multiple stages of structural lung morphogenesis, cellular differentiation, and the response to injury. As a driver of lung airway branching morphogenesis, FGF10 signaling defects during development lead to neonatal lung disease. Lung diseases impact patients across the lifespan, from infants in the first minutes of life through the aged population. Congenital abnormalities of lung structure can cause lung disease at birth or make adults more suscept...
TMPY-04424	MST3 Protein, Human, Recombinant (His) HEL-S-95,STE20,MST3B,RP11-111L24.5,MST3,STK3,serine/threonin...	Human	Baculovirus Insect Cells
	Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis plays an important role in the protection of kidneys from ischemia-reperfusion injury.
TMPY-02201	Peroxiredoxin 6 Protein, Human, Recombinant (His) p29,PRX,1-Cys,HEL-S-128m,peroxiredoxin 6,NSGPx,AOP2,aiPLA2	Human	E. coli
	PRDX6, a member of antioxidant protein superfamily, plays an important role in oxidative stress, catabolism of lipids and phospholipid lipisomes. Peroxiredoxin 6 (PRDX6) is involved in redox regulation of the cell and is thought to be protective against oxidant injury. Peroxiredoxin 6 (PRDX6) is a bifunctional protein with both glutathione peroxidase (GPx) and iPLA2 activities，which are concomitantly increased with the expression of PRDX6. PRDX6 promoted lung tumor growth in an in vivo allograft...
TMPH-03266	CHI3L1 Protein, Rat, Recombinant (His) Chi3l1,Cartilage glycoprotein 39,CGP-39,GP-39,Chitinase-3-li...	Rat	E. coli
	Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mu...
TMPH-02834	PAI-1 Protein, Mouse, Recombinant (His & SUMO) Endothelial plasminogen activator inhibitor,Serpine1,Serpin ...	Mouse	E. coli
	Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of ...
TMPY-02946	TAFA2/FAM19A2 Protein, Human, Recombinant (hFc) TAFA2,family with sequence similarity 19 (chemokine (C-C mot...	Human	HEK293 Cells
	FAM19A2 belongs to the FAM19/TAFA family. FAM19/TAFA family members are chemokine-like proteins. The biological functions of TAFA family members remain to be determined, but there are a few tentative hypotheses. First, TAFAs may modulate immune responses in the CNS by functioning as brain specific chemokines, and may act with other chemokines to optimize the recruitment and activity of immune cells in the CNS. Second, TAFAs may represent a novel class of neurokines that act as regulators of immu...
TMPH-03753	MYLK Protein, Human, Recombinant (His) MYLK,Myosin light chain kinase, smooth muscle,Telokin,Kinase...	Human	E. coli
	Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl...

重组蛋白

RON/CD136 Protein, Human, Recombinant (His)

Cat.No: TMPY-02028

Species: Human

Expression System: HEK293 Cells

MMP-12 Protein, Human, Recombinant (catalytic domain)

Cat.No: TMPY-02869

Species: Human

Expression System: E. coli

FGF-10 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated

Cat.No: TMPK-00096

Species: Human

Expression System: E. coli

MST3 Protein, Human, Recombinant (His)

Cat.No: TMPY-04424

Species: Human

Expression System: Baculovirus Insect Cells

Peroxiredoxin 6 Protein, Human, Recombinant (His)

Cat.No: TMPY-02201

Species: Human

Expression System: E. coli

CHI3L1 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03266

Species: Rat

Expression System: E. coli

PAI-1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02834

Species: Mouse

Expression System: E. coli

TAFA2/FAM19A2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02946

Species: Human

Expression System: HEK293 Cells

MYLK Protein, Human, Recombinant (His)

Cat.No: TMPH-03753

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0254	Linalool-d3
	Linalool-d3 是 Linalool 的氘代化合物。Linalool 的 CAS 号为 78-70-6。Linalool 是存在芫荽等植物中的单萜类天然产物，是竞争性NMDA受体拮抗剂，具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤，具有镇痛、抗菌和抗炎的特性。

同位素标记化合物

Cat.No: TMID-0254

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