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Cat. No. | Product Name | Target | Signaling Pathways |
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T6111 |
Selisistat
EX-527,司来司他,SEN0014196 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Selisistat (EX-527) 是一种去乙酰化酶 SIRT1 的抑制剂 (IC50=38 nM),具有有效性和特异性。Selisistat 可以用于神经系统疾病如亨廷顿舞蹈病的研究。 | |||
T7100 |
PLX5622
PLX-5622 |
c-Fms; CSF-1R | Tyrosine Kinase/Adaptors |
PLX5622 是一种选择性的、高效的、能透过血脑屏障的、口服具有活性的 CSF1R 抑制剂 (IC50= 0.016 µM;Ki= 5.9 nM),具有较好的药理学特性,可用于病程发展前和过程中,扩大的和特异性的小胶质细胞的消除。 | |||
T7530 |
PD146176
NSC168807 |
Ferroptosis; Lipoxygenase; Autophagy | Apoptosis; Autophagy; Metabolism |
PD146176 (NSC-168807) 是一种 15-脂氧合酶(15-LO)抑制剂,抑制兔网织红细胞 15-LO,Ki 为 197 nM,IC50 为 0.54 μM。 它通过刺激老年三重转基因小鼠的自噬来逆转认知障碍、脑淀粉样变性和 tau 病理学。 | |||
T23709 |
alphaSYN-IN-NAB2
alphaSYN inhibitor NAB2,alphaSYNINNAB2,alphaSYN-IN-NAB2,NAB2,alphaSYN inhibitor-NAB2 |
Others | Others |
alphaSYN-IN-NAB2 是一种神经元保护剂,是一种由 NAB2基因编码的蛋白质。NAB2 高效且具有选择性地保护多种细胞免受 α-syn 毒性。NAB2 对依赖于 E3 泛素连接酶 Rsp5/Nedd4 的内体转运具有促进作用。NAB2 确定 α-syn 生物学中的一个可活性分子节点,该节点可以纠正其潜在病理学的多个方面,包括功能失调的内体和内质网到高尔基体囊泡的运输。NAB2参与细胞分化、凋亡和应激反应等细胞过程,可用来研究癌症、神经发育和神经元活动。 | |||
T26879 |
BNC-1
BNC 1 |
Others | Others |
BNC-1 is a modulator of amyloid pathology. BNC-1 significantly decreases amyloid burden and improves markers of synaptic integrity in well-established mouse models of amyloid deposition by promoting phosphorylation and activation of Elk-1. | |||
T30437 |
BF 126
BF-126,BF126 |
Others | Others |
BF 126 has potential applications in vivo imaging of tau pathology in Alzheimer's disease | |||
T25525 |
IDT
|
Others | Others |
IDT is an orally active TNFα modulator. It acts by altering neutrophil infiltration, improving cognition and diminishing tau and amyloid pathology in the 3xTgAD mouse model. | |||
T26223 |
SR1555 HCl
SR-1555,SR1555,SR 1555 |
Others | Others |
SR1555 is a selective RORγ inverse agonist that inhibits the development and function of TH17 cells, a subset of T cells that have been involved in the pathology of several autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. | |||
T60042 |
NPT200-11
|
Others | Others |
NPT200-11 是一种口服生物利用度和脑穿透性 ASYN 错误折叠和聚集抑制剂。 NPT200-11 可用于突触核蛋白病的潜在病理学研究,包括帕金森病 (PD)、路易体痴呆 (DLB) 和多系统萎缩 (MSA)。 | |||
T39607 |
NLRP3 modulators 1
NLRP3 modulators 1 |
Others | Others |
NLRP3 modulators 1 (WO2017184746A1, compound 107) is a potent modulator of NLRP3, capable of agonizing or partially agonizing the activity of NLRP3. This compound proves valuable in investigating conditions, diseases, or disorders where a reduction in LRP3 activity plays a role in the pathology. | |||
T40355 |
IL-17A modulator-2
|
Others | Others |
IL-17A modulator-2, exhibits inhibitory properties towards IL-17A, with a pIC50 of 8.3. Its effectiveness lies in attenuating the biological effects associated with IL-17A activity. IL-17A modulator-2 finds utility in the study of diseases and disorders characterized by dysregulated IL-17A modulation, such as those involving immune dysfunction, autoimmune pathology, cancer, and neurodegenerative conditions. | |||
T78774 |
MMP13-IN-4
|
MMP | Proteases/Proteasome |
MMP13-IN-4(compound 13)作为MMP-13抑制剂,具备强效性和选择性,其IC50值为14.6 μM,可用于骨关节炎疼痛的研究。 | |||
T78775 |
MMP13-IN-5
|
MMP | Proteases/Proteasome |
MMP13-IN-5 (compound 13m) 作为具有针对性的MMP-2/MMP-13 抑制剂,显示出高效的抑制活性(IC50=3.6 μM/14.6 μM),适用于骨关节炎疼痛的研究。 | |||
T75827 |
UFP-803 TFA
|
||
UFP-803 TFA 是有效的urotensin-II receptor (UT)配体。UFP-803 TFA 具有较低的残留激动剂活性,因此它可以作为研究UT 系统在生理学和病理学中作用的重要工具。 | |||
T61130 |
SSTR4 agonist 3
|
Others | Others |
SSTR4 agonist 3 is a potent compound that activates the SSTR4 receptor. The SSTR4 receptor is highly expressed in the hippocampus and neocortex, which are regions associated with memory, learning, and Alzheimer's disease pathology. SSTR4 agonists demonstrate strong efficacy in rodent models of pain, both acute and chronic, by reducing peripheral nociception and inflammation. Considering its potential application in pain research, SSTR4 agonist 3 is of interest[1]. | |||
T75779 |
β-Amyloid (12-28) (TFA)
|
||
β-Amyloid (12-28) (TFA)为β-淀粉样蛋白(β1-42)的肽片段,后者是由42个氨基酸组成,构成老年斑核心的关键蛋白。β-Amyloid (12-28) (TFA)展现出聚集性质,并可能对阿尔茨海默氏病研究具有潜在价值。 | |||
T60543 |
THK-523
|
Others | Others |
THK-523 在体内外都显示出对tau 的选择性和高亲和力。18F-THK-523 是一种有效的 tau 成像放射性示踪剂,它是用于研究阿尔茨海默病的有效体内 tau 成像配体。 | |||
TP2301 |
type II collagen fragment
|
Others | Others |
Type II collagen is composed of a triple helix of three identical α chains. These molecules associate to form a fibril that is stabilized by intermolecular crosslinks1. Damage to the fibrillar meshwork, made up of primarily type II collagen (z 90–95%), ma | |||
T12505 |
PLX5622 hemifumarate
|
c-Fms | Tyrosine Kinase/Adaptors |
PLX5622 hemifumarate 是高度选择性的、能透过血脑屏障的、具有口服活性的 CSF1R 抑制剂,IC50值为 0.016 μM,Ki 值为 5.9 nM,可用于病程发展前和过程中,扩大和特异性的小胶质细胞的消除。PLX5622 hemifumarate 具有较理想的药代动力学特性。 | |||
T60911 |
SSTR4 agonist 4
|
Others | Others |
SSTR4 agonist 4 是一种有效的SSTR4激动剂,具有用于疼痛研究的潜力。SSTR4 激动剂在与急性和慢性相关的抗外周伤害感受和抗炎活性相关疼痛的啮齿动物模型中有效。SSTR4 在海马和新皮质、记忆和学习区域以及阿尔茨海默病病理学中的表达水平相对较高。 | |||
T37697L |
D-GsMTx4 TFA
|
TRP/TRPV Channel; Piezo Channel | Membrane transporter/Ion channel |
D-GsMTx4 TFA 是一种具有选择性的蜘蛛毒液肽,是一种TRPC1 / 6和Piezo2抑制剂,可抑制属于 Piezo 和 TRP 通道家族的阳离子可渗透的机械敏感性通道 (MSCs),阻断阳离子选择性的拉伸激活通道 (SAC),减弱溶血磷脂酰胆碱 (LPC) 诱导的星形胶质细胞毒性和小胶质细胞反应性。D-GsMTx4 TFA 在小鼠缺血/再灌注模型中预防心肌梗死,可用于鉴定兴奋性 MSC 在正常生理学和病理学中的作用。 | |||
T36947 |
Pyrithiamine (hydrobromide)
|
Others | Others |
Pyrithiamine is the pyridine analog of thiamine that prevents growth of organisms that require intact thiamine. [1] It inhibits the growth of bacterial and fungal species at a pyrithiamine:thiamine ratio of 10:1 in growth media and induces symptoms of thiamine deficiency in mice at a dietary ratio of 3:1. These effects are reversible with addition of sufficient thiamine in all species. Pyrithiamine inhibits the formation of cocarboxylase from thiamine in chicken blood in a dose-dependent manner.... | |||
T35507 |
12-HETE
|
Others | Others |
(±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers . It aggregates neutrophils with an EC50 value of 40 nM.[1] Reference:[1]. O'Flaherty, J.T., Thomas, M.J., Lees, C.J., et al. Neutrophil-aggregating activity of monohydroxyeicosatetraenoic acids. American Journal of Pathology 104, 55-62 (1981). | |||
T35639 |
Sulfatides (bovine) (sodium salt)
|
||
Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. They are produced from the combination of ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus. The ceramide portion contains variable fatty acid chain lengths, which are tissue- and pathology-dependent. Sulfatides are primarily found in the myelin sheath of oligodendrocytes and Schwann cells, wit... | |||
T35892 |
Q134R
Q134R |
Others | Others |
Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer’s disease (AD) and aging-related disorders research[1]. Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo... | |||
T35836 |
PMX-205 (trifluoroacetate salt)
|
Others | Others |
PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4 1.March, D.R., Proctor, L.M., Stoermer, M.J., et al.Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Rela... | |||
T35890 |
Pentosidine
|
Others | Others |
Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling.[1][2] Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of ... | |||
T35799 |
MBX-8025 (sodium salt)
|
Others | Others |
MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increases in fasting blood glucose and serum insulin levels, and decreases insulin resistance in Alms1 mutant (foz/foz) mice fed an atherogenic diet as a model of diet-induced obesity, type 2 diabetes, and non-alcoholic steatohepatitis (NASH).2 It also decreases serum alanine transamin... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02956 |
Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)
APOL1,apolipoprotein L1,APOL,FSGS4,APOL-I,APO-L |
Human | Baculovirus Insect Cells |
APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney, and brain. APOL1 belongs to the apolipoprotein L family. It may play a role in lipid exchange and transport throughout the body. It may also participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomer... | |||
TMPK-00191 |
PILRA Protein, Mouse, Recombinant (hFc)
PILR-α,FDF03,PILRA,PILR-alpha,PILRalpha,PILRα |
Mouse | HEK293 Cells |
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognitive performance; Mild Cognitive Impairment (MCI) is instead an objective decline in cognitive performance that does not reach pathology. Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a cell surface inhibitory receptor that was recently suggested to be involved in AD pathogenesis. In particular, the arginine-to-glycine substitution in position 78 (R78, rs1859788) was shown to be p... | |||
TMPY-02393 |
Thimet Oligopeptidase/THOP1 Protein, Mouse, Recombinant (His)
thimet oligopeptidase 1,EP24.15,AI131655,AI327041 |
Mouse | Baculovirus Insect Cells |
THOP1, also known as Thimet oligopeptidase 1, Thimet oligopeptidase, EC 3.4.24.15, or EP24.15, is a zinc(II) endopeptidase implicated in the processing of numerous physiological peptides. As an intracellular enzyme, highly expressed in the brain, kidneys and neuroendocrine tissue, THOP1 has been proposed to metabolize peptides within cells, thereby affecting antigen presentation and G protein-coupled receptor signal transduction. Its substrates is gonadotrophin-releasing hormone (GnRH), an impor... | |||
TMPJ-00028 |
CCL2 Protein, Mouse, Recombinant
Ccl2,Je,Mcp1,C-C motif chemokine 2,Platelet-derived growth f... |
Mouse | E. coli |
C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major... | |||
TMPY-02045 |
SECTM1 Protein, Human, Recombinant (His)
K12,secreted and transmembrane 1 |
Human | HEK293 Cells |
Secreted and transmembrane 1 (SECTM1), also known as K12, is a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein of SECTM family. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. The human K12 protein has been shown to be primarily expressed in spleen, prostate, testis, small intestine, and in peripheral blood leukocytes. The K12 protein is expressed on the cell surface in such sma... | |||
TMPJ-00920 |
CD40 Ligand Protein, Mouse, Recombinant (aa 112-260, His)
TNFSF5,Tumor necrosis factor ligand superfamily member 5,CD4... |
Mouse | HEK293 Cells |
CD40 Ligand, also known as TNFSF5, CD154, is a type II transmembrane glycoprotein member of the TNF superfamily. Mature mouse CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain, a transmembrane segment, and a 214 aa extracellular region. CD40 Ligand is expressed as a homotrimer on platelets and activated T cells and B cells. It is upregulated following stimulation of basophils, eosinophils, fibroblasts, mast cells, monocytes, natural killer cells, vascular endothelial cells, and sm... | |||
TMPJ-01312 |
TWEAKR/TNFRSF12A Protein, Mouse, Recombinant (hFc)
Fibroblast growth factor-regulated protein 2,TNFRSF12,Tumor ... |
Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 12A(Tnfrsf12a) is a single-pass type I membrane protein and contains 1 TNFR-Cys repeat. It is weak inducer of apoptosis in some cell types.It promotes angiogenesis and it is the proliferation of endothelial cells. It may modulate cellular adhesion to matrix proteins.TNFR binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors. TNF is a naturally occurring cytokine that is involved in normal inf... | |||
TMPY-01290 |
CHIT1 Protein, Human, Recombinant (His)
chitinase 1 (chitotriosidase),CHITD,CHI3,CHIT |
Human | HEK293 Cells |
Chitotriosidase, also known as Chitinase-1 and CHIT1, is a member of the glycosyl hydrolase 18 family and Chitinase class II subfamily. It is a member of the mammalian chitinase family, structurally homologous to chitinases from other species, is synthesized and secreted by specifically activated macrophages. Chitotriosidase is a polymer of N-acetylglucosamine. Serum and plasma chitotriosidase activity is usually measured as the first step in diagnosis of Gaucher disease. Monitoring chitotriosid... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T36903 |
Rasagiline-13C3 (mesylate)
Rasagiline-13C3 (mesylate) |
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Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede... |