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101

抑制剂 & 化合物

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化合物库

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同位素标记化合物

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Cat. No. Product Name
L5400 抗心血管疾病化合物库

1408 compounds
1408 种心血管疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;
L4800 血管生成库

1353 compounds
1353 个高潜力的抑制或促进血管生成的小分子集合,可用于药物靶点开发、血管生成机理研究的高通量筛选,高内涵筛选;
L8500 HIF-1化合物库

1336 compounds
1336 个HIF-1相关小分子的独特集合,可用于缺血性疾病、癌症等相关领域的药物开发和药理研究;

化合物库

抗心血管疾病化合物库
Cat.No: L5400
Compounds: 1408
血管生成库
Cat.No: L4800
Compounds: 1353
HIF-1化合物库
Cat.No: L8500
Compounds: 1336
Cat. No. Product Name Target Signaling Pathways
T15130 Dilazep dihydrochloride

Others Others
Dilazep dihydrochloride 是一种腺苷摄取的抑制剂。它可抑制缺血性损伤,血小板聚集和核苷的膜转运。它能够增强腺苷的作用,进而具有脑和冠状血管舒张作用。
T2423 P7C3-A20

Others Others
P7C3-A20 是促神经原性和神经保护活性的 P7C3 衍生物。它具有抗抑郁活性,能够透过血脑屏障,并可用于研究脑损伤。
TP1856 Colivelin

Beta Amyloid; STAT JAK/STAT signaling; Neuroscience; Stem Cells
Colivelin 是一种神经保护肽和 STAT3 的激活剂,是一种合成的杂合肽,可增强 humanin (HN) 的神经保护作用。它通过激活 STAT3 在体外抑制神经元死亡,具有潜力用于阿尔茨海默病和缺血性脑损伤的相关研究。
T22749 DR2313

DR 2313

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
DR2313 是一种选择性,竞争性的和可透过血脑屏障的PARP 抑制剂,对PARP-1和PARP-2的IC50值分别为 0.20 和 0.24 μM。它在体内外均有对缺血性损伤的神经保护作用。
T7946 AER-271

Aquaporin Membrane transporter/Ion channel
AER-271 是一种 AER-270 的膦酸酯前药,是aquaporin-4抑制剂,有用于急性缺血性中风的研究潜力。
T39341 FCPR03

PDE Metabolism
FCPR03 是一种特异性磷酸二酯酶 4 (PDE4) 抑制剂,对 PDE4B1、PDE4D7 和 PDE4 催化结构域的 IC50 分别为 31 nM、47 nM 和 60 nM。 FCPR03 具有神经保护、抗炎和抗抑郁样作用。
T3074 CHIR 98024

CHIR98014

GSK-3; S6 Kinase MAPK; PI3K/Akt/mTOR signaling; Stem Cells
CHIR 98024是一种有效的 GSK-3α/β 抑制剂,在无细胞试验中 IC50 为 0.65 nM/0.58 nM,能够区分 GSK-3 与其接近的同源物 Cdc2 和 ERK2。
T5326 Sugammadex sodium

Org25969,Sugammadex (sodium),舒更葡糖钠

Others Others
Sugammadex sodium (Org25969) 是合成的 γ 环糊精衍生物,是一种新型的神经肌肉阻断逆转剂。
T8869 B355252

Others Others
B355252 是苯氧基噻吩磺酰胺小分子,NGF 受体激动剂。它能增强 NGF 诱导的神经突生长。它可减轻 DNA 损伤、抑制 ROS 生成、降低 LDH 水平以及预防神经元凋亡,保护缺血性神经元免受神经元损失。它具有抗细胞凋亡作用。
T20843 Aplodan

Nergize,Creatinolfosfate,磷酸肌肉醇,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate

Others Others
Aplodan (creatinol-O-phosphate) 表现出抗缺血和抗心律失常的能力以及对细胞膜的保护作用。 Aplodan 可用于缺血性心脏病或伴有持续性室性早搏的缺血性心脏病的研究。
T0368 Cinepazide maleate

马来酸桂哌齐特,MD-67350,Vasodistal,Brendil

Calcium Channel Membrane transporter/Ion channel; Metabolism
Cinepazide maleate (MD-67350) 是哌嗪衍生物,是一种钙通道阻滞剂,也是一种强效血管扩张剂,可用于脑血管疾病的研究,如缺血性中风和脑梗塞等。
T23146 PHA 568487 free base

PHA 568487

AChR Neuroscience
PHA 568487 free base 是一种选择性的 α7 烟碱乙酰胆碱受体激动剂,可用于减缓神经炎症。
T0154 Nebivolol hydrochloride

R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824

Apoptosis; Adrenergic Receptor Apoptosis; GPCR/G Protein; Neuroscience
Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂,IC50为0.8 nM。
T6595 Moexipril hydrochloride

莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925

Apoptosis; RAAS Apoptosis; Endocrinology/Hormones
Moexipril hydrochloride (Moexipril HCl) 是一种有口服活性的,不含巯基的血管紧张素转化酶抑制剂,可治疗高血压和充血性心力衰竭。
T39195 YM-244769 dihydrochloride

Calcium Channel Membrane transporter/Ion channel; Metabolism
YM-244769 dihydrochloride 是一种有效的 Na+/Ca2+ exchange 3 (NCX3) 抑制剂,IC50 为 18 nM。 YM-244769 dihydrochloride 对神经元和肾脏具有有效的保护作用。
T9888 YM-244769

3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-

Calcium Channel Membrane transporter/Ion channel; Metabolism
YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) 是一种有效的 Na+/Ca2+ exchange 3 (NCX3) 抑制剂,IC50 为 18 nM。 YM-244769 对神经元和肾脏具有有效的保护作用。
T19659 Annaosanchun

雄甾-3,5,6三醇,YC6,YC-6,YC 6

Others; AMPK Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
Annaosanchun (YC-6) 有可能用于治疗急性缺血性中风(AIS)。
T78141 LFHP-1c

Phosphatase Metabolism
LFHP-1c 是一种新型 PGAM5 抑制剂,在缺血性脑卒中模型中显示出神经保护活性,可防止大鼠短暂性大脑中动脉闭塞(tMCAO)后的BBB破坏。LFHP-1c 可用于研究脑缺血性中风。
T26645 Aptiganel

CNS 1102,CNS-1102,CNS1102

NMDAR Neuroscience
Aptiganel (CNS-1102) 是一种非竞争性 NMDA 拮抗剂,是一种多肽,可用于研究急性缺血性卒中。
T77442 Glenzocimab

ACT017

Others Others
Glenzocimab (ACT017) 是人源化抗 GPVI 单克隆抗体的 Fab 片段。Glenzocimab 在缺血性卒中模型对胶原诱导的血小板聚集显示出抑制作用。Glenzocimab 具有研究急性缺血性脑卒中和脑血栓。
T27630 Isbogrel

CV4151,CV-4151,CV 4151

Prostaglandin Receptor GPCR/G Protein; Immunology/Inflammation
Isbogrel (CV4151)是一种小分子血栓素A2合成酶(TXA2 synthase)抑制剂,可用来研究心律失常、短暂性脑缺血发作和血栓形成。
T16286 Nelonemdaz

Salfaprodil free base,Neu2000

Antioxidant; NMDAR Neuroscience; oxidation-reduction
Nelonemdaz (Neu2000) 是一种 NMDA 受体拮抗剂,具有抗氧化活性和神经保护活性,可用于研究脑梗死再灌注损伤和急性缺血性卒中。
T0988 Trimetazidine dihydrochloride

盐酸曲美他嗪,Yoshimilon,Kyurinett,Vastarel F

Autophagy; Fatty Acid Synthase Autophagy; Metabolism
Trimetazidine dihydrochloride (Vastarel F) 是细胞保护性抗缺血剂,也用作缺血性心脏病或心绞痛的血管扩张剂,具有抗氧化,抗炎,抗伤害和胃保护作用。它可通过抑制脂肪酸代谢提高心肌葡萄糖利用率。
T39463 Asundexian

BAY 2433334,Asundexian,BAY2433334,BAY-2433334

Factor Xa Metabolism
Asundexian (BAY-2433334) 是一种高效且具有口服活性凝血因子 FXIa 抑制剂,可直接且可逆地与FXIa 的活性位点结合,从而抑制其活性。Asundexian 对缓冲液中的人 FXIa 的 IC50 为 1 nM。Asundexian 具有抗肿瘤活性,可用于研究急性缺血性卒中、短暂性脑缺血发作和缺血性卒中。
T29687 Afacifenacin

Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986

AChR Neuroscience
Afacifenacin (SMP-986) fumarate 是一种 M3 毒蕈碱受体选择性拮抗剂,可用于研究缺血性心脏病,尿失禁和膀胱炎和其他疾病。
T7355 IC87201

Others; iGluR Membrane transporter/Ion channel; Neuroscience; Others
IC87201 是 PSD95-nNOS 相互作用的抑制剂,可抑制 nMDAR 诱导的一氧化氮和 cGMP 的形成,可用于缺血性中风和疼痛的研究。
T0080 Trapidil

唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008

PDGFR; PDE Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
Trapidil (Avantrin) 是一种抗血小板药物,是一种血管扩张剂,有特异性血小板衍生生长因子。
T77611 DAPK-IN-2

WAY-380496

DAPK Apoptosis
DAPK-IN-2 (WAY-380496) 是一种 DAPK 抑制剂。 DAPK-IN-2 具有潜在的抗癌活性,可调节细胞发生自噬反应,可用于研究脑梗死和缺血性疾病。
T28607 Rocepafant

LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730

Platelet aggregation Others
Rocepafant (LAU8080) 是一种血小板活化因子(PAF)拮抗剂,可减轻新生大鼠缺氧缺血性脑损伤。Rocepafant 抑制肿瘤坏死因子-Afa 介导的小鼠 L929 肿瘤细胞的细胞毒性。
T24115 GSK854

GSK-854,GSK 854

Apoptosis Apoptosis
GSK854 是一种具有高选择性和有效性的肌钙蛋白 I 相互作用激酶 (TNNI3K) 抑制剂,抑制小鼠心肌梗死损伤细胞焦亡和细胞凋亡,可限制缺血性心脏的氧化应激、损伤和不良重塑。
T28518 Repinotan HCl

X-3702,X 3702,Bayx3702,X3702,Bay-x-3702,Bay x 3702

5-HT Receptor GPCR/G Protein; Neuroscience
Repinotan HCl (Bay-x-3702) 是一种可透过血脑屏障且具有口服活性、选择性和高效性的 5-HT1A 受体激动剂,是一种氨甲基苯并联苯胺衍生物。RRepinotan HCl 具有强效的神经保护作用,可用于研究缺血性卒中和创伤性脑损伤。
T24239 K201

K-201,JTV 519,JTV-519,K 201

Calcium Channel Membrane transporter/Ion channel; Metabolism
K201 (JTV-519) 是一种 Ca2+ 依赖性阻滞剂,通过稳定兰尼碱受体来防止缺血性心脏和骨骼肌 (SkM) 中的肌质网异常 Ca(2+) 泄漏。
T29645 Adatanserin hydrochloride

WY50324 hydrochloride

5-HT Receptor GPCR/G Protein; Neuroscience
Adatanserin hydrochloride (WY50324 hydrochloride) 是一种新型 5-HT(1A)/5-HT(2) 受体配体,具有潜在的神经保护作用,抑制内源性氨基酸缺血性外排,可用于研究抑郁症和焦虑症。
T90611 PF-03049423

Others Others
PF-03049423 是一种高效、高选择性的 phosphodiesterase-5A 抑制剂,对大鼠和人血小板酶的 IC50 约为 0.2 nM。PF-03049423 可用于急性缺血性中风的研究。
T73447 NP10679

P450; HER; NMDAR; Histamine Receptor Angiogenesis; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
NP10679 是一种可口服且具有选择性、脑穿透性、高效性和 pH 敏感性的 GluN2B 亚基的 N-methyl-D-aspartate (NMDA) 受体抑制剂。NP10679 抑制 histamine H1 、 hERG 通道和 CYP 酶,可用于研究癫痫和缺血性卒中。
T21757 BRL 52537 hydrochloride

Opioid Receptor Endocrinology/Hormones; GPCR/G Protein; Neuroscience
BRL 52537 hydrochloride 是一种选择性和特异性 KOR 激动剂,与缺血性神经元损伤的神经保护有关。它用于研究中风和心脏病发作的潜在治疗方法以及更一般的大脑研究。
T61934 Repinotan

BAY x 3702 free base

5-HT Receptor GPCR/G Protein; Neuroscience
Repinotan (BAY x 3702 free base) 是一种可透过血脑屏障(BBB)且具有口服活性和选择的 5-HT1A 受体激动剂,具有神经保护活性,可拮抗吗啡诱导的麻醉大鼠通气抑制,可用于研究急性缺血性中风和创伤性脑损伤。
T3527 TRC051384

TRC 051384

HSP Cytoskeletal Signaling; Metabolism
TRC051384 是一种热休克蛋白70 (HSP70) 诱导剂,可减少中风相关的神经元损伤并增加短暂性缺血性中风大鼠模型的存活率,激活热休克因子-1 并导致分子伴侣和抗炎活性升高,增强神经元和神经胶质细胞中 Hsp72 的表达。
T13112 Tat-NR2B9c

Tat-NR2Bct,NA-1

NO Synthase; iGluR Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
Tat-NR2B9c (NA-1) 是一种突触后密度-95(PSD-95)抑制剂,具有神经保护和抗癫痫作用。Tat-NR2B9c 可抑制PSD-95d2、 PSD-95d1 和 PSD-95,可阻止NMDA诱导的神经元NADPH氧化酶的激活,从而阻断超氧化物的产生,可减少中风后急性期的缺血性损伤。
T21509 CA 074

Cysteine Protease Proteases/Proteasome
CA 074 是一种高效的组织蛋白酶B (cathepsin B) 抑制剂, Ki 值为2 to 5 nM。CA 074 抑制灵长类动物缺血性海马神经元死亡,可减轻 SJL/J 小鼠诱导的实验性自身免疫性脑脊髓炎的视网膜病变和视神经炎。
T31206 Darexaban

YM 150,Darexaban, Tanexaban,YM150

Factor Xa Metabolism
Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂,IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。
T21871 MMPSI

Caspase-3/7 Inhibitor I

Apoptosis; Caspase Apoptosis; Proteases/Proteasome
MMPSI (Caspase-3/7 Inhibitor I) 是一种新型的、非肽类的小分子 caspase 3 和 caspase 7 抑制剂,可减少离体兔心脏或心肌细胞缺血性损伤的作用,以浓度依赖性方式抑制 H16c2 细胞凋亡 。MMPSI 可用于研究心脏保护和心肌损伤。
T36569 KR-32568

Sodium Channel Membrane transporter/Ion channel
KR-32568是一种钠/氢交换器1(NHE-1)抑制剂(IC50:230 nM)。KR-32568具有强大的心脏保护作用。当使用浓度为10μM 时,它能在离体的缺血大鼠心脏模型中恢复心脏收缩功能。KR-32568(0.3mg/kg)在缺血和再灌注损伤的大鼠模型中减少了心肌梗死的大小。
T70540 Pinokalant

LOE-908

SARS-CoV; TRP/TRPV Channel Membrane transporter/Ion channel; Microbiology/Virology
Pinokalant (LOE-908) 是一种新型非选性阳离子通道抑制剂。Pinokalant 在体内实验中可显著减少皮质梗死体积,可改善缺血半影区的代谢和电生理状态,可减少大鼠大脑中动脉闭塞后急性期磁共振图像上的病变大小。Pinokalant是一种潜在的SARS-CoV-2蛋白酶抑制剂,可用于研究脑卒中。
T50100 3-hydroxy-3-phenylpentanamide

Others Others
3-hydroxy-3-phenylpentanamide 是一种手性化合物,属于β-羟基酰胺类。在神经病学中,它已被证明对缺血性脑损伤和脑出血具有神经保护作用。在精神病学中,它被研究为焦虑、抑郁和成瘾的潜在治疗方法。在肿瘤学中,它已被证明通过诱导细胞凋亡和抑制肿瘤生长而具有抗肿瘤活性。
T36503 Sodium Hydrogen Sulfide (hydrate)

Others Others
Sodium Hydrogen Sulfide (hydrate) 与一氧化氮一样,是一种重要的气体介质,对哺乳动物的免疫、神经、心血管和肺系统有重要影响。Sodium Hydrogen Sulfide (hydrate)是一种H2S 供体,常用于细胞和整个动物实验系统。例如,它被用来证明H2S 促进中性粒细胞迁移,减少气道炎症,保护神经轴突、心脏和肠道免受化学或缺血再灌注损伤。
T37299 L-Palmitoylcarnitine chloride

Palmitoyl-L-carnitine chloride

ATPase Membrane transporter/Ion channel
L-Palmitoylcarnitine chloride (Palmitoyl-L-carnitine chloride)是一种脂肪酸代谢产物,具有抗血栓形成的作用,通过抵消tMCAO模型中的脑内血栓形成来保护小鼠免受缺血性中风。L-Palmitoylcarnitine chloride抑制心脏中的Na/K泵,抑制 FeCl 3诱导的动脉血栓形成,减轻了短暂性大脑中动脉闭塞(tMCAO)小鼠模型的脑内血栓形成和炎症。
T26018 R 59494

R-59494,R59494

Others Others
R 59494 is a novel anti-ischemic molecule.
T13642 Deloxolone

(3β,20β)-3-(3-Carboxy-1-oxopropoxy)olean-9(11)-en-29-oic acid

Others Others
Deloxolone shows potential in treating inflammatory, ischemic, and proliferative diseases.
T34086 Platonin

NK 19

Others Others
Platonin is a therapeutic immunomodulating medicine and a possible medicine against ischemic stroke.

化合物

Dilazep dihydrochloride
Cat.No: T15130
Synonym:
Target: Others
P7C3-A20
Cat.No: T2423
Synonym:
Target: Others
Colivelin
Cat.No: TP1856
Synonym:
Target: Beta Amyloid, STAT
DR2313
Cat.No: T22749
Synonym: DR 2313
Target: PARP
AER-271
Cat.No: T7946
Synonym:
Target: Aquaporin
FCPR03
Cat.No: T39341
Synonym:
Target: PDE
CHIR 98024
Cat.No: T3074
Synonym: CHIR98014
Target: GSK-3, S6 Kinase
Sugammadex sodium
Cat.No: T5326
Synonym: Org25969,Sugammadex (sodium),舒更葡糖钠
Target: Others
B355252
Cat.No: T8869
Synonym:
Target: Others
Aplodan
Cat.No: T20843
Synonym: Nergize,Creatinolfosfate,磷酸肌肉醇,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate
Target: Others
Cinepazide maleate
Cat.No: T0368
Synonym: 马来酸桂哌齐特,MD-67350,Vasodistal,Brendil
Target: Calcium Channel
PHA 568487 free base
Cat.No: T23146
Synonym: PHA 568487
Target: AChR
Nebivolol hydrochloride
Cat.No: T0154
Synonym: R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824
Target: Apoptosis, Adrenergic Receptor
Moexipril hydrochloride
Cat.No: T6595
Synonym: 莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925
Target: Apoptosis, RAAS
YM-244769 dihydrochloride
Cat.No: T39195
Synonym:
Target: Calcium Channel
YM-244769
Cat.No: T9888
Synonym: 3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-
Target: Calcium Channel
Annaosanchun
Cat.No: T19659
Synonym: 雄甾-3,5,6三醇,YC6,YC-6,YC 6
Target: Others, AMPK
LFHP-1c
Cat.No: T78141
Synonym:
Target: Phosphatase
Aptiganel
Cat.No: T26645
Synonym: CNS 1102,CNS-1102,CNS1102
Target: NMDAR
Glenzocimab
Cat.No: T77442
Synonym: ACT017
Target: Others
Isbogrel
Cat.No: T27630
Synonym: CV4151,CV-4151,CV 4151
Target: Prostaglandin Receptor
Nelonemdaz
Cat.No: T16286
Synonym: Salfaprodil free base,Neu2000
Target: Antioxidant, NMDAR
Trimetazidine dihydrochloride
Cat.No: T0988
Synonym: 盐酸曲美他嗪,Yoshimilon,Kyurinett,Vastarel F
Target: Autophagy, Fatty Acid Synthase
Asundexian
Cat.No: T39463
Synonym: BAY 2433334,Asundexian,BAY2433334,BAY-2433334
Target: Factor Xa
Afacifenacin
Cat.No: T29687
Synonym: Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986
Target: AChR
IC87201
Cat.No: T7355
Synonym:
Target: Others, iGluR
Trapidil
Cat.No: T0080
Synonym: 唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008
Target: PDGFR, PDE
DAPK-IN-2
Cat.No: T77611
Synonym: WAY-380496
Target: DAPK
Rocepafant
Cat.No: T28607
Synonym: LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730
Target: Platelet aggregation
GSK854
Cat.No: T24115
Synonym: GSK-854,GSK 854
Target: Apoptosis
Repinotan HCl
Cat.No: T28518
Synonym: X-3702,X 3702,Bayx3702,X3702,Bay-x-3702,Bay x 3702
Target: 5-HT Receptor
K201
Cat.No: T24239
Synonym: K-201,JTV 519,JTV-519,K 201
Target: Calcium Channel
Adatanserin hydrochloride
Cat.No: T29645
Synonym: WY50324 hydrochloride
Target: 5-HT Receptor
PF-03049423
Cat.No: T90611
Synonym:
Target: Others
NP10679
Cat.No: T73447
Synonym:
Target: P450, HER, NMDAR, Histamine Receptor
BRL 52537 hydrochloride
Cat.No: T21757
Synonym:
Target: Opioid Receptor
Repinotan
Cat.No: T61934
Synonym: BAY x 3702 free base
Target: 5-HT Receptor
TRC051384
Cat.No: T3527
Synonym: TRC 051384
Target: HSP
Tat-NR2B9c
Cat.No: T13112
Synonym: Tat-NR2Bct,NA-1
Target: NO Synthase, iGluR
CA 074
Cat.No: T21509
Synonym:
Target: Cysteine Protease
Darexaban
Cat.No: T31206
Synonym: YM 150,Darexaban, Tanexaban,YM150
Target: Factor Xa
MMPSI
Cat.No: T21871
Synonym: Caspase-3/7 Inhibitor I
Target: Apoptosis, Caspase
KR-32568
Cat.No: T36569
Synonym:
Target: Sodium Channel
Pinokalant
Cat.No: T70540
Synonym: LOE-908
Target: SARS-CoV, TRP/TRPV Channel
3-hydroxy-3-phenylpentanamide
Cat.No: T50100
Synonym:
Target: Others
Sodium Hydrogen Sulfide (hydrate)
Cat.No: T36503
Synonym:
Target: Others
L-Palmitoylcarnitine chloride
Cat.No: T37299
Synonym: Palmitoyl-L-carnitine chloride
Target: ATPase
R 59494
Cat.No: T26018
Synonym: R-59494,R59494
Target: Others
Deloxolone
Cat.No: T13642
Synonym: (3β,20β)-3-(3-Carboxy-1-oxopropoxy)olean-9(11)-en-29-oic acid
Target: Others
Platonin
Cat.No: T34086
Synonym: NK 19
Target: Others
Cat. No. Product Name Target Signaling Pathways
T19466 N8-Acetylspermidine dihydrochloride

N8-乙酰基亚精胺二盐酸盐

Endogenous Metabolite Metabolism
N8-Acetylspermidine dihydrochloride 是一种多胺物质。
T6S1294 Nicotiflorin

Nictoflorin,Kaempferol-3-O-Rutinoside,山奈酚-3-O-芸香糖苷,Nicotifloroside

Others Others
Nicotiflorin (Kaempferol-3-O-Rutinoside) 是一种黄酮苷,从传统中药Flos Carthami 中提取得到。它有抗糖化活性和神经保护作用。
T6S1495 Ginsenoside Rk3

人参皂苷Rk3,人参皂甙 Rk3

Others; NF-κB NF-κB; Others
Ginsenoside Rk3 是存在于 Panax notoginseng 的根中。它能够抑制 HepG2 细胞中 TNF-α 诱导的 NF-κB 转录活性,IC50=14.24±1.30 μM。
T3871 Daucosterol

Alexandrin,Sitogluside,β-Sitosterol β-D-glucoside,Eleutheroside A,西托糖苷

Glucosidase Metabolism
Daucosterol (Sitogluside) 是天然的甾醇体类化合物。
T8074 Esafosfan trisodium

Fosfructose trisodium,D-果糖-1,6-二磷酸三钠盐,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium

Others; Endogenous Metabolite Metabolism; Others
Esafosfan trisodium (FDP trisodium) 是一种细胞保护性的天然糖磷酸盐,用于镰状细胞性贫血,心血管缺血和哮喘的研究。Fosfructose trisodium 通过刺激无氧糖酵解起作用,其在缺血条件下产生三磷酸腺苷。
TN1956 Mulberrofuran G

Phosphatase; HBV; Glucosidase Metabolism; Microbiology/Virology
Mulberrofuran G分离自自 Morus alba L.,具有抗乙型肝炎病毒活性,可保护缺血损伤诱导的细胞死亡。Mulberrofuran G 是一种 PTP1B 和 α-葡萄糖苷酶的双重抑制剂,可用于研究阿尔茨海默症。
T3228 Fosfructose

D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,二磷酸果糖,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan

Others; Endogenous Metabolite Metabolism; Others
D-fructose-1,6-diphosphate 是一种细胞保护性的天然糖磷酸盐,Fosfructose 通过刺激无氧糖酵解起作用,其在缺血条件下产生三磷酸腺苷,有潜力用于心血管缺血,镰状细胞性贫血和哮喘的研究。
T20793 Magnesium Lithospermate B

丹參酸B鎂,Monomethyl lithospermate B,丹参酸 B 镁,Lithospermate B

Others Others
Magnesium Lithospermate B 是一种咖啡酸四聚体的衍生物,从Salviae miltiorrhizae 中提取得到。它能够抑制神经炎症并减轻神经变性。它被广泛用于心血管疾病的研究,并且可以防止葡萄糖引起的细胞内氧化损伤。
T2S1008 Oxysophoridine

Sophoridine N-oxide,氧化槐定碱

Apoptosis; Antioxidant Apoptosis; oxidation-reduction
Oxysophoridine (Sophoridine N-oxide) 是从苦豆子中提取的一种生物碱,具有抗发炎,抗氧化应激和抗凋亡的作用。
T3752 4-Hydroxybenzyl alcohol

4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇

Apoptosis; Endogenous Metabolite Apoptosis; Metabolism
4-Hydroxybenzyl alcohol (P-Methylolphenol) 是广泛分布于各种植物中的一种酚类天然产物,具有抗炎、抗氧化和抗伤害感受活性。它抑制肿瘤血管生成和生长,有神经保护作用。
T6S0659 Rhynchophylline

钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin

Calcium Channel; NF-κB Membrane transporter/Ion channel; Metabolism; NF-κB
Rhynchophylline (Mitrinermine) 是一种生物碱类化合物,从钩藤中分离得到,具有很高的生物活性,被广泛用于抗炎、神经保护等方面的研究。
TL0008 Gigantol

Wnt/beta-catenin; Glucosidase Cytoskeletal Signaling; Metabolism; Stem Cells
Gigantol 是一种联苄基化合物,从几种药用兰花中获得,是一种Wnt/β-catenin 通路抑制剂,具有抗肿瘤活性。
T3S1553 trans-Cinnamaldehyde

Cinnamaldehyde,Cinnamic aldehyde,桂皮醛,反式肉桂醛,Cinnamal,Phenylacrolein

COX; Endogenous Metabolite Immunology/Inflammation; Metabolism; Neuroscience
trans-Cinnamaldehyde (Phenylacrolein) 是一种能够用于合成反式肉桂醛-β-环糊精复合物,一种能够食用的抗菌涂层,能够延长鲜切水果的保质期。它是一种能够通过烷基异氰化物与乙炔二羧酸二烷基酯的反应来合成高度多官能的呋喃环。
T5S1632 Barlerin

8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01

VEGFR; TNF; NF-κB; Akt; Caspase Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors
Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷,从中国西藏民间药用植物中分离得到,能够抑制NF-κB 活性。
T4S2326 Cornuside

7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside

ERK; p38 MAPK; NF-κB; JNK MAPK; NF-κB
Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷,可用于炎症疾病的研究和促进血液循环。 它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应,用于炎性过敏性疾病中的潜能。
T3S2259 Methyl eugenol

4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物,存在于植物叶子、果实、根茎中,当植物相应的部位因食草动物进食而受损时,就会释放。它可用于消灭雄性东方果蝇。
TN1412 Astringin

trans-Astringin,白皮杉醇葡萄糖苷

IL Receptor; Others Immunology/Inflammation; Others
Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin in the ischemic and ischemic-reperfused hearts may be correlated with its antioxidant activity and upregulation of NO production.
T4S0280 Eleutheroside D

Eleutheroside has protective effect to myocardial ischemic-reperfusion injury(IRI) in isolated rats.
TN3612 Caulophine

Others Others
Caulophine has the ability to protect cardiomyocytes from oxidative and ischemic injury through an antioxidative mechanism.
T74191 Tanshinol borneol ester

Others Others
Tanshinol borneol ester 是一种血管生成刺激剂,通过 Akt 和 MAPK 信号通路促进血管生成的多个关键步骤。Tanshinol borneol ester 具有抗缺血和抗动脉粥样硬化作用。
T2S0118 Daurinoline

Calcium Channel; 5-HT Receptor; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury. Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline.
TN5498 6,7,4'-Trihydroxyflavanone

Others Others
6,7,4'-Trihydroxyflavanone 具有多种药理活性,包括抗风湿、抗缺血、抗炎、抗破骨细胞和对 METH 诱导的 T 细胞失活的保护作用。 6,7,4'-三羟基黄烷酮可用于研究治疗患有神经退行性疾病的 METH 成瘾者。
TN3323 Monomethyl lithospermate

Lithospermic acid monomethyl ester

Akt; PI3K Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Monomethyl lithospermate (Lithospermic acid monomethyl ester) 具有潜在的抗病毒活性,通过激活PI5K/Akt信号传导,减轻体内大脑中动脉闭塞小鼠缺血性中风损伤,并在体外保护氧葡萄糖剥夺/复氧诱导的SHSY-3Y细胞。Monomethyl lithospermate 能提高 SHSY-5Y 细胞的生存能力,抑制线粒体膜电位 (MMOP) 崩溃,抑制细胞凋亡。Monomethyl lithospermate 还降低中动脉闭塞 (MCAO) 大鼠脑组织中的氧化应激水平,改善缺血性中风 (IS) 大鼠神经损伤。
TN5164 trans-Hinokiresinol

IL Receptor; TNF; NOS; LTR Apoptosis; Immunology/Inflammation
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyasol (cis-hinokiresinol) are estrogen

天然产物

N8-Acetylspermidine dihydrochloride
Cat.No: T19466
Synonym: N8-乙酰基亚精胺二盐酸盐
Target: Endogenous Metabolite
Nicotiflorin
Cat.No: T6S1294
Synonym: Nictoflorin,Kaempferol-3-O-Rutinoside,山奈酚-3-O-芸香糖苷,Nicotifloroside
Target: Others
Ginsenoside Rk3
Cat.No: T6S1495
Synonym: 人参皂苷Rk3,人参皂甙 Rk3
Target: Others, NF-κB
Daucosterol
Cat.No: T3871
Synonym: Alexandrin,Sitogluside,β-Sitosterol β-D-glucoside,Eleutheroside A,西托糖苷
Target: Glucosidase
Esafosfan trisodium
Cat.No: T8074
Synonym: Fosfructose trisodium,D-果糖-1,6-二磷酸三钠盐,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium
Target: Others, Endogenous Metabolite
Mulberrofuran G
Cat.No: TN1956
Synonym:
Target: Phosphatase, HBV, Glucosidase
Fosfructose
Cat.No: T3228
Synonym: D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,二磷酸果糖,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan
Target: Others, Endogenous Metabolite
Magnesium Lithospermate B
Cat.No: T20793
Synonym: 丹參酸B鎂,Monomethyl lithospermate B,丹参酸 B 镁,Lithospermate B
Target: Others
Oxysophoridine
Cat.No: T2S1008
Synonym: Sophoridine N-oxide,氧化槐定碱
Target: Apoptosis, Antioxidant
4-Hydroxybenzyl alcohol
Cat.No: T3752
Synonym: 4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇
Target: Apoptosis, Endogenous Metabolite
Rhynchophylline
Cat.No: T6S0659
Synonym: 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin
Target: Calcium Channel, NF-κB
Gigantol
Cat.No: TL0008
Synonym:
Target: Wnt/beta-catenin, Glucosidase
trans-Cinnamaldehyde
Cat.No: T3S1553
Synonym: Cinnamaldehyde,Cinnamic aldehyde,桂皮醛,反式肉桂醛,Cinnamal,Phenylacrolein
Target: COX, Endogenous Metabolite
Barlerin
Cat.No: T5S1632
Synonym: 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01
Target: VEGFR, TNF, NF-κB, Akt, Caspase
Cornuside
Cat.No: T4S2326
Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside
Target: ERK, p38 MAPK, NF-κB, JNK
Methyl eugenol
Cat.No: T3S2259
Synonym: 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚
Target: GABA Receptor
Astringin
Cat.No: TN1412
Synonym: trans-Astringin,白皮杉醇葡萄糖苷
Target: IL Receptor, Others
Eleutheroside D
Cat.No: T4S0280
Synonym:
Target:
Caulophine
Cat.No: TN3612
Synonym:
Target: Others
Tanshinol borneol ester
Cat.No: T74191
Synonym:
Target: Others
Daurinoline
Cat.No: T2S0118
Synonym:
Target: Calcium Channel, 5-HT Receptor, Histamine Receptor
6,7,4'-Trihydroxyflavanone
Cat.No: TN5498
Synonym:
Target: Others
Monomethyl lithospermate
Cat.No: TN3323
Synonym: Lithospermic acid monomethyl ester
Target: Akt, PI3K
trans-Hinokiresinol
Cat.No: TN5164
Synonym:
Target: IL Receptor, TNF, NOS, LTR
Cat. No. Product Name Species Expression System
TMPY-00545 Dermcidin Protein, Human, Recombinant (hFc)

AIDD,PIF,HCAP,dermcidin,DCD-1,DSEP

Human HEK293 Cells
Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely diagnoses. Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. And the role of DCD in ischemic heart disease has drawn increasing attention in particular its relationship with insulin secretion and glycemic control, nitric oxide (NO) synthesis ...
TMPY-00344 ARL6IP6 Protein, Human, Recombinant (mFc)

PFAAP1,AIP-6,ADP-ribosylation factor-like 6 interacting prot...

Human HEK293 Cells
It had been found that a homozygous truncating mutation in ARL6IP6 as the likely cause of a syndromic form of CMTC associated with major dysmorphism, developmental delay, transient ischemic attacks and cerebral vascular malformations. This gene was previously implicated by genome wide association study (GWAS) as a susceptibility locus to ischemic stroke in young adults. We identify ARL6IP6 as a novel candidate gene for a syndromic form of CMTC. This suggests that ischemic stroke or transient isc...
TMPH-03391 TRIM2 Protein, Rat, Recombinant (His)

Trim2,Tripartite motif-containing protein 2,E3 ubiquitin-pro...

Rat E. coli
E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. TRIM2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.5 kDa and the accession number is D3ZQG6.
TMPJ-00681 EDIL3 Protein, Human, Recombinant (His)

EGF-Like Repeats and Discoidin I-Like Domains 3,EDIL3

Human HEK293 Cells
EGF-Like Repeat and Discoidin I-Like Domain-Containing Protein 3 (EDIL3) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. EDIL3 becomes quiescent at the time of birth, and is no longer expressed in normal adult tissues. EDIL3 has been found to be re-expressed in a number of human tumors as well as in ischemic muscles and ischemic brain tissue, which may play an important role in adult angiogenesis. EDIL3 promotes adherence a...
TMPJ-01257 PMM1 Protein, Human, Recombinant (His)

PMMH22,PMM 1,PMMH-22,PMM1,Phosphomannomutase 1

Human E. coli
Phosphomannomutase 1 (PMM1) blongs to the eukaryotic PMM family. Phosphomannomutase 1 can catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose which required for a number of critical mannosyl transfer reactions. PMM1 is highly expressed in liver, heart, brain, and pancreas, but lower expression in skeletal muscle. In addition, PMM1 may be responsible for the...
TMPH-01634 MLYCD Protein, Human, Recombinant (His & Myc)

MLYCD,Malonyl-CoA decarboxylase, mitochondrial

Human E. coli
Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic ...
TMPY-02298 ACYP2 Protein, Human, Recombinant (GST)

ACYM,acylphosphatase 2, muscle type,ACYP

Human E. coli
Recent genome-wide association studies have identified genetic variants in ACYP2 and WFS1 that are associated with cisplatin-induced ototoxicity. We sought to explore the role of these genetic susceptibility factors to cisplatin-induced ototoxicity in patients with testicular cancer. Telomere length, as a marker of biological aging, has been reported to influence the risk of several age-related diseases, including ischemic stroke. Recent studies have identified the genetic variant within ACYP2 a...
TMPY-02376 BNIP3L Protein, Human, Recombinant

BCL2/adenovirus E1B 19kDa interacting protein 3-like,NIX,BNI...

Human E. coli
The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to the endoplasmic reticulum and Golgi apparatus of wild-type newborn mouse lenses and is contained within mitochondria, endoplasmic reticulum and Golgi apparatus isolated from adult mouse liver. As the cells become packed with keratin bundles, Bnip3L expression triggers mitophagy to...
TMPY-00410 EPHX2 Protein, Human, Recombinant (His)

SEH,CEH,epoxide hydrolase 2, cytoplasmic

Human Baculovirus Insect Cells
Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the human EPHX2 gene had been implicated in susceptibility to cardiovascular disease, including stroke. The human EPHX2 mutations may in part explain the genetic variability in sensitivity to ischemic brain injury and stroke outcome. Epoxide hydrolase is involved in metabolism of vas...
TMPJ-00785 FABP3 Protein, Human, Recombinant (His)

H-FABP,FABP11,Fatty Acid-Binding Protein Heart,MDGIMuscle Fa...

Human E. coli
Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, FABP3 is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-types. They form 14-15 kDa proteins and are thought to p...
TMPY-01875 SCGN Protein, Human, Recombinant (His)

SEGN,SECRET,DJ501N12.8,CALBL,secretagogin, EF-hand calcium b...

Human E. coli
Secretagogin, also known as SCGN, is a secreted protein that is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin / SCGN is restricted to distinct subtypes ...
TMPY-01709 HIF-1 alpha Protein, Human, Recombinant (His)

bHLHe78,HIF-1 α,hypoxia inducible factor 1, alpha subunit (b...

Human E. coli
HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has...

重组蛋白

Dermcidin Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00545
Species: Human
Expression System: HEK293 Cells
ARL6IP6 Protein, Human, Recombinant (mFc)
Cat.No: TMPY-00344
Species: Human
Expression System: HEK293 Cells
TRIM2 Protein, Rat, Recombinant (His)
Cat.No: TMPH-03391
Species: Rat
Expression System: E. coli
EDIL3 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00681
Species: Human
Expression System: HEK293 Cells
PMM1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01257
Species: Human
Expression System: E. coli
MLYCD Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01634
Species: Human
Expression System: E. coli
ACYP2 Protein, Human, Recombinant (GST)
Cat.No: TMPY-02298
Species: Human
Expression System: E. coli
BNIP3L Protein, Human, Recombinant
Cat.No: TMPY-02376
Species: Human
Expression System: E. coli
EPHX2 Protein, Human, Recombinant (His)
Cat.No: TMPY-00410
Species: Human
Expression System: Baculovirus Insect Cells
FABP3 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00785
Species: Human
Expression System: E. coli
SCGN Protein, Human, Recombinant (His)
Cat.No: TMPY-01875
Species: Human
Expression System: E. coli
HIF-1 alpha Protein, Human, Recombinant (His)
Cat.No: TMPY-01709
Species: Human
Expression System: E. coli
Cat. No. Product Name Target Signaling Pathways
TMIJ-0094 Trimetazidine-d8 Dihydrochloride

Trimetazidine-d8 Dihydrochloride 是 Trimetazidine Dihydrochloride 的氘代化合物。Trimetazidine Dihydrochloride 的 CAS 号为 13171-25-0。Trimetazidine dihydrochloride 是细胞保护性抗缺血剂,也用作缺血性心脏病或心绞痛的血管扩张剂,具有抗氧化,抗炎,抗伤害和胃保护作用。它可通过抑制脂肪酸代谢提高心肌葡萄糖利用率。
TMIJ-0070 Androstane-3,5,6-triol-d4

Androstane-3,5,6-triol-d4 是 Androstane 的氘代化合物。Androstane 的 CAS 号为 4725-51-3。Annaosanchun 有可能用于治疗急性缺血性中风(AIS)。
TMID-0040 Palmitoyl L-Carnitine-d3 Hydrochloride

Palmitoyl L-Carnitine-d3 Hydrochloride 是 Palmitoyl L-Carnitine Hydrochloride 的氘代化合物。Palmitoyl L-Carnitine Hydrochloride 的 CAS 号为 18877-64-0。L-Palmitoylcarnitine chloride (Palmitoyl-L-carnitine chloride)是一种脂肪酸代谢产物,具有抗血栓形成的作用,通过抵消tMCAO模型中的脑内血栓形成来保护小鼠免受缺血性中风。L-Palmitoylcarnitine chloride抑制心脏中的Na/K泵,抑制 FeCl 3诱导的动脉血栓形成,减轻了短暂性大脑中动脉闭塞(tMCAO)小鼠模型的脑内血栓形成和炎症。

同位素标记化合物

Trimetazidine-d8 Dihydrochloride
Cat.No: TMIJ-0094
Synonym:
Target:
Androstane-3,5,6-triol-d4
Cat.No: TMIJ-0070
Synonym:
Target:
Palmitoyl L-Carnitine-d3 Hydrochloride
Cat.No: TMID-0040
Synonym:
Target:
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