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Search Results for " duration "

Targets Recommended: Adenosine Receptor

73

抑制剂 & 化合物

1

天然产物

4

化合物库

4

重组蛋白

9

同位素标记化合物

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Cat. No.	Product Name
DF4000	Smart共价片段化合物库		511 compounds
	ChemDiv’s Smart Library of Covalent Fragments contains 799 compounds
L9410	共价抑制剂库		1920 compounds
	1920 种小分子的独特集合，包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子，如氯乙酰基，2-氯丙酰基，丙烯酰基，1-丙-2-炔基，1-丁-2-炔基，酮羰基，二硫键等，可以用于共价抑制剂药物研发；
L7110	抗高血压化合物库		678 compounds
	678 种高血压相关的小分子，用于高通量和高内涵筛选；
DO2200	共价抑制剂库CD		12000 compounds
	数量多：超过12000种共价结合化合物，并且数量在持续增加；

化合物库

Smart共价片段化合物库

Cat.No: DF4000

Compounds: 511

共价抑制剂库

Cat.No: L9410

Compounds: 1920

抗高血压化合物库

Cat.No: L7110

Compounds: 678

共价抑制剂库CD

Cat.No: DO2200

Compounds: 12000

Cat. No.	Product Name	Target	Signaling Pathways
T16136	MRS-1706	Adenosine Receptor	GPCR/G Protein; Neuroscience
	MRS-1706 是一种选择性A2B 腺苷受体的反向激动剂，对人 A2B、A2A、A1和 A3受体的Ki 值分别为 1.39、112、157 和 230 nM。
T8581	Flecainide hydrochloride	Others	Others
	Flecainide hydrochloride 是一种用于预防和治疗异常快速心率的药物。这包括室性和室上性心动过速。
T0802	Procaine hydrochloride Novocaine HCl,Procaine HCl,盐酸普鲁卡因	Histone Demethylase; 5-HT Receptor; DNA/RNA Synthesis; Sodium Channel; NMDAR; AChR	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Procaine hydrochloride (Novocaine HCl) 是DNA 脱甲基剂，是一种苯甲酸衍生物，具有局部麻醉和抗心律失常特性。
T0029	Procaine Duracaine,Spinocaine,普鲁卡因,Novocaine,Vitamin H3,奴夫卡因	Histone Demethylase; DNA/RNA Synthesis; Sodium Channel	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel
	Procaine (Vitamin H3) 是DNA 脱甲基剂，是一种酯类局部麻醉剂。它起效缓慢，作用持续时间短，主要用于浸润麻醉、周围神经阻滞和脊髓阻滞。
T22371	Mivacurium dichloride 米库氯铵,Mivacurium chloride,二氯美维库铵	AChR	Neuroscience
	Mivacurium dichloride (Mivacurium chloride) 是苄基异喹啉衍生物，可与 nAChR 偶联，以减少或抑制乙酰胆碱对肌肉细胞末端盘的去极化作用。它也是非去极化短效的神经肌肉阻滞剂和骨骼肌松弛剂。
T20968	CyPPA	Potassium Channel; Dopamine Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	CyPPA 是hSK2和hSK3的阳性调节剂，其EC50值分别为 5.6 μM 和14 μM。它对 hSK1 和 hIK 通道无活性。
T0015	Mephenesin Cresoxydiol,甲酚甘油醚,Memphenesin,Mephedan,Decontractyl	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Mephenesin (Cresoxydiol) 是 NMDA 受体拮抗剂，也是中枢性肌松弛剂。
T0916	Butamben Butyl 4-aminobenzoate,4-氨基苯甲酸丁酯	Potassium Channel; Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Butamben (Butyl 4-aminobenzoate) 是一种长效局部麻醉剂，用于治疗慢性疼痛。
T28829	Soquinolol Soquinolol mucate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Soquinolol (Soquinolol mucate) 是一种β肾上腺素能受体拮抗剂，具有较弱的局部麻醉活性。Soquinolol 具有良好的肠内疗效和较长的作用持续时间。
T21335	Fluorogestone acetate Flurogestone Acetate Flugestone Acetate Fluorogesterone Acetate SC9880,氟孕酮醋酸酯	Others	Others
	Fluorogestone acetate 显示出高效力且活性持续时间短，并且在生理上与孕酮相似。 FGA 的效力大约是黄体酮的 20-25 倍。
T7198	E-4031 (1S)-1,5-脱水-1-C-[4-氯-3-[[4-[2-(环丙氧基)乙氧基]苯基]甲基]苯基]-D-山梨醇	EGFR; Potassium Channel	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	E-4031是甲磺酰苯胺III 类抗心律失常药，选择性地阻断hERG 钾通道。
T0780	Pyridostigmine bromide 溴吡斯的明,Mestinon,溴化吡啶斯的明	AChE	Neuroscience
	Pyridostigmine bromide (Mestinon) 是一种可逆的胆碱酯酶抑制剂。
T5585	AM-92016 hydrochloride	Potassium Channel	Membrane transporter/Ion channel
	AM-92016 hydrochloride 是一种整流钾电流的特异性阻断剂。它能够延迟整流钾通道，使膜复极化，限制神经冲动的持续时间。
T6397	Atracurium besylate Tracrium,51W89,BW-33A,苯磺酸阿曲库铵	AChR	Neuroscience
	Atracurium besylate (51W89) 是一种神经肌肉阻断剂，ED95为0.2 mg/kg。
T19735	Flucycloxuron 氟螨脲,(E)-flucycloxuron,Andalin	Others	Others
	Flucycloxuron ((E)-flucycloxuron) 是一种甲壳素合成抑制剂，用作杀虫剂。在昆虫模型中，该抑制剂已被证明会影响几种生殖事件，例如产卵前的持续时间。
T4250	Bilastine 比拉斯汀,Bilaxten	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bilastine (Bilaxten) 是新型抗组胺药，对H1组胺受体具有高度选择性，起效快，作用时间长的特性，可用于变应性鼻结膜炎和荨麻疹。
T1439	Lacidipine SN-305,拉西地平,GX-1048,GR-43659X	Apoptosis; Calcium Channel; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	Lacidipine (SN-305) 是一种L 型钙离子通道阻断剂。
T4497	Amifampridine 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine	Others	Others
	Amifampridine (3,4-Diaminopyridine) 可用于罕见肌肉疾病的研究。
T1410	Torsemide AC-4464,JDL-464,托拉塞米,Torasemide	Na-K-Cl cotransporter	Membrane transporter/Ion channel
	Torsemide (AC-4464) 是具有口服活性的亨氏环利尿剂，也具有抗醛固酮和血管舒张活性。它可用于研究心力衰竭、肾脏疾病、肝硬化。
T3574	Sematilide hydrochloride 司美利特,CK-1752A,CK-1752,Sematilide HCl	Potassium Channel	Membrane transporter/Ion channel
	Sematilide hydrochloride (CK-1752) 是一种选择性的 IKr 通道阻滞剂。Sematilide 以浓度依赖性抑制延迟整流钾通道 (K+current)，IC50为 25 μM。Sematilide 是一种 III 类抗心律不齐剂。
T30249	AZD 7009 AZD-7009,AZD7009	Sodium Channel	Membrane transporter/Ion channel
	AZD 7009是一种新型抗心律失常化合物，对CHO K1细胞中 hNav1.5的钠电流具有抑制作用，IC50为11 uM。AZD 7009 对离体兔心房和心室肌细胞的晚期钠电流具有抑制作用，对e -4031诱导的动作电位持续时间延长具有抑制作用，促使浦肯野纤维的早期后去极化(EADs)。
T1144	Lidocaine hydrochloride Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin	Apoptosis; ERK; NF-κB; MEK; Sodium Channel	Apoptosis; MAPK; Membrane transporter/Ion channel; NF-κB
	Lidocaine hydrochloride (Lignocaine hydrochloride) 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine 是一种酰胺衍生物，是一种研究室性心律失常的药物和有效的肿瘤抑制剂。
T6476	Dofetilide UK 68789,UK-68798,Tikosyn,多非利特	Potassium Channel	Membrane transporter/Ion channel
	Dofetilide (UK 68789) 是一种具有口服活性、有效的且特异性的IKr 阻滞剂，作为 III 类抗心律失常药物。Dofetilide 可用于心血管疾病研究。
T6541	Ibutilide Fumarate Corvert Fumarate,U70226E,富马酸伊布利特	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Ibutilide Fumarate (U70226E) 是一种 III 类抗心律失常药物，可作用于急性心梗阻塞。
T1496	Amiodarone hydrochloride 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone	Potassium Channel; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物，通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间，可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化，可研究室上性和室性心律失常。
T1281	Tropicamide Ro 1-7683,托吡卡胺	AChR	Neuroscience
	Tropicamide (Ro 1-7683) 是一种选择性的 M4毒蕈碱乙酰胆碱受体拮抗剂，作为滴眼剂使用时，会产生短效瞳孔扩张和睫状肌麻痹。
T14835	BTRX-335140 CYM-53093	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	BTRX-335140 (CYM-53093) 是一种有效的选择性口服活性 κ 阿片受体 (KOR) 拮抗剂，对 κOR、μOR 和 δOR 具有拮抗活性，IC50 值分别为 0.8、110 和 6500 nM。它可以很好地分布到 CNS 中，在大鼠中具有良好的体外吸收、分布、代谢、排泄和毒性以及体内药代动力学特征。
T1787	Levobupivacaine	Sodium Channel	Membrane transporter/Ion channel
	Levobupivacaine 是一种氨基酰胺类局麻药，属于n-alkylsubstituted pipecoloxylidide 家族。它是bupivacaine 的 S-对映异构体。
T0807	Tribromoethyl alcohol 2,2,2-Tribromoethanol,Avertin,Basibrol,Tribromoethanol,三溴乙醇,TBE	Others	Others
	Tribromoethyl alcohol (Avertin) 具有麻醉活性，常被用作实验动物的麻醉剂，尤其是啮齿类动物。Tribromoethyl alcohol 的麻醉时间短，麻醉起效快。
T38294	4-Deoxypyridoxine hydrochloride	S1P Receptor	GPCR/G Protein
	4-Deoxypyridoxine hydrochloride 通过抑制 S1P 裂解酶 (SPL) 活性来抑制细胞内 S1P 的降解，与 S1P 一样，减少化学诱导的胰岛素瘤细胞系的细胞凋亡。
T20477	Cgp 29287 Cgp29,287,Cgp29287,Cgp 29,287,Cgp-29,287,Cgp-29287	Others	Others
	Cgp 29287 is a primate-specific renin inhibitor. It also has a prolonged duration of action.
T11525	GW311616	Others	Others
	GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
T27394	Furalazine Furalazinum,Panfuran,Nifuralazinum,NFT	Others	Others
	Furalazine is an antimicrobial agent. Furalazine was more effective in reducing the duration of positive stool culture than chloramphenicol. It may be potentially used in the treatment of cholera.
T11525L	GW311616 hydrochloride GW311616A	Others	Others
	GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
T40140	Zanamivir-Cholesterol Conjugate	Others	Others
	Zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains.
T33534	Muzolimine Edrul,Muzolimina,Muzoliminum	Others	Others
	Muzolimine is pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects.
T28567	Ro 22-9194 Ro-22-9194	Others	Others
	Ro 22-9194 is a class I antiarrhythmic agent. Ro 22-9194 (>=10 μM) caused a concentration-dependent decrease in the maximum upstroke velocity and shortening of action potential duration in guinea-pig ventricular cells.
T15269	Falecalcitriol	Others	Others
	Falecalcitriol is an analog of calcitriol. It has a higher potency both in vivo and in vitro systems, which is longer duration of action in vivo.
T61685	Ibutilide	Others	Others
	Ibutilide (U70226E free base) is a potent antiarrhythmic compound that extends the action potential duration. It effectively blocks the rapidly activating delayed rectifier potassium current (I Kr ) in AT-1 cells [1].
T22315	Doxapram	Others	Others
	Doxapram, a central respiratory stimulant with a brief duration of action, is a selective TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel inhibitor with EC50 of 410 nM, 37 μM, 9 μM, respectively.
TP2076	[Phe8Ψ(CH-NH)-Arg9]-Bradykinin
	Selective bradykinin B2 receptor agonist that is resistant to carboxypeptidase cleavage. 5-fold more potent and exhibits a more prolonged duration of action than bradykinin in vivo.
T61659	CC214-2	Others	Others
	CC214-2 is a potent dual inhibitor of mTORC1 and mTORC2, known for its ability to impede autophagy by modulating mammalian target of rapamycin (mTOR) signaling. With this capacity, CC214-2 shows promise in shortening the duration of tuberculosis (TB) [1].
T71147	PBS-1086	Others	Others
	PBS-1086 is a novel dual inhibitor of the canonical and noncanonical NF-κB pathways, increasing the magnitude and duration of initial EGFR inhibitor response in multiple NSCLC models, decreasing PDHK1 expression, and suppressing phosphorylation of the PDHK1 protein substrate PDHA1 in a panel of PTEN-deficient cell lines.
T28901	T-2007 5,5-Diphenylbarbituric acid,DPB	Others	Others
	T-2007 is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist and gamma-aminobutyric acid (GABA) receptor agonist. T2007 and its analogs upregulates CYP3A4 and MDR1. T-2007 depressed both the degree and the duration of postt
T26724	AZD-9164 bromide AZD9164,AZD-9164,AZD 9164	Others	Others
	AMG-221 is a potent and selective 11β-HSD1 inhibitor. AMG 221 potently blocked 11β-HSD1 activity, producing sustained inhibition for the 24-hour study duration as measured in ex vivo adipose samples. AMG-221 decreased fed blood glucose and insulin levels
T70473	Parapenzolate Free Base	Others	Others
	Parapenzolate Free Base is a safe and effective anticholinergic drug possessing antisecretory and antimotility properties and prolonged duration of action. Clinical investigation has shown that after an oral dose of the drug there was inhibition of both basal and histamine-stimulated acid outputs.
T82163	Human enteropeptidase-IN-3	Others	Others
	Human enteropeptidase-IN-3是一种肽类酶抑制剂，主要作用于肠肽酶，具有长效抑制功能。该化合物广泛应用于研究肠道消化相关疾病。
T70257	Avitriptan HCl	Others	Others
	Avitriptan, also known as BMS-180048, is a selective 5-HT1-like receptor agonist. Avitriptan is an effective compound for the treatment of migraine headaches with a prolonged duration of response. Avitriptan Is a Ligand and Agonist of Human Aryl Hydrocarbon Receptor That Induces CYP1A1 in Hepatic and Intestinal Cells.
T80738	Z-FK-ck Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone
	Z-FK-ck (Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone) 作为一种选择性gingipain-K抑制剂，具有在剂量和时间依赖性的方式上延长血浆凝血酶时间 (TT) 的特性。
T73910	Efrotomycin	Others	Others
	Efrotomycin 是一种口服有效的抗生素。Efrotomycin 能够从链霉菌 S.Lactamdurans 中分离得到。Efrotomycin 对感染的猪的鼠伤寒沙门氏菌数量、持续时间、脱落率和抗菌敏感性均无显著影响。

化合物

Cat.No: T16136

Target: Adenosine Receptor

Flecainide hydrochloride

Cat.No: T8581

Target: Others

Procaine hydrochloride

Cat.No: T0802

Synonym: Novocaine HCl,Procaine HCl,盐酸普鲁卡因

Target: Histone Demethylase, 5-HT Receptor, DNA/RNA Synthesis, Sodium Channel, NMDAR, AChR

Cat.No: T0029

Synonym: Duracaine,Spinocaine,普鲁卡因,Novocaine,Vitamin H3,奴夫卡因

Target: Histone Demethylase, DNA/RNA Synthesis, Sodium Channel

Mivacurium dichloride

Cat.No: T22371

Synonym: 米库氯铵,Mivacurium chloride,二氯美维库铵

Target: AChR

Cat.No: T20968

Target: Potassium Channel, Dopamine Receptor

Cat.No: T0015

Synonym: Cresoxydiol,甲酚甘油醚,Memphenesin,Mephedan,Decontractyl

Target: NMDAR, iGluR

Cat.No: T0916

Synonym: Butyl 4-aminobenzoate,4-氨基苯甲酸丁酯

Target: Potassium Channel, Calcium Channel, Sodium Channel

Cat.No: T28829

Synonym: Soquinolol mucate

Target: Adrenergic Receptor

Fluorogestone acetate

Cat.No: T21335

Synonym: Flurogestone Acetate Flugestone Acetate Fluorogesterone Acetate SC9880,氟孕酮醋酸酯

Target: Others

Cat.No: T7198

Synonym: (1S)-1,5-脱水-1-C-[4-氯-3-[[4-[2-(环丙氧基)乙氧基]苯基]甲基]苯基]-D-山梨醇

Target: EGFR, Potassium Channel

Pyridostigmine bromide

Cat.No: T0780

Synonym: 溴吡斯的明,Mestinon,溴化吡啶斯的明

Target: AChE

AM-92016 hydrochloride

Cat.No: T5585

Target: Potassium Channel

Atracurium besylate

Cat.No: T6397

Synonym: Tracrium,51W89,BW-33A,苯磺酸阿曲库铵

Target: AChR

Cat.No: T19735

Synonym: 氟螨脲,(E)-flucycloxuron,Andalin

Target: Others

Cat.No: T4250

Synonym: 比拉斯汀,Bilaxten

Target: Histamine Receptor

Cat.No: T1439

Synonym: SN-305,拉西地平,GX-1048,GR-43659X

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species

Cat.No: T4497

Synonym: 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine

Target: Others

Cat.No: T1410

Synonym: AC-4464,JDL-464,托拉塞米,Torasemide

Target: Na-K-Cl cotransporter

Sematilide hydrochloride

Cat.No: T3574

Synonym: 司美利特,CK-1752A,CK-1752,Sematilide HCl

Target: Potassium Channel

Cat.No: T30249

Synonym: AZD-7009,AZD7009

Target: Sodium Channel

Lidocaine hydrochloride

Cat.No: T1144

Synonym: Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel

Cat.No: T6476

Synonym: UK 68789,UK-68798,Tikosyn,多非利特

Target: Potassium Channel

Ibutilide Fumarate

Cat.No: T6541

Synonym: Corvert Fumarate,U70226E,富马酸伊布利特

Target: Calcium Channel, Sodium Channel

Amiodarone hydrochloride

Cat.No: T1496

Synonym: 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone

Target: Potassium Channel, Adrenergic Receptor, Autophagy

Cat.No: T1281

Synonym: Ro 1-7683,托吡卡胺

Target: AChR

Cat.No: T14835

Synonym: CYM-53093

Target: Opioid Receptor

Levobupivacaine

Cat.No: T1787

Target: Sodium Channel

Tribromoethyl alcohol

Cat.No: T0807

Synonym: 2,2,2-Tribromoethanol,Avertin,Basibrol,Tribromoethanol,三溴乙醇,TBE

Target: Others

4-Deoxypyridoxine hydrochloride

Cat.No: T38294

Target: S1P Receptor

Cat.No: T20477

Synonym: Cgp29,287,Cgp29287,Cgp 29,287,Cgp-29,287,Cgp-29287

Target: Others

Cat.No: T11525

Target: Others

Cat.No: T27394

Synonym: Furalazinum,Panfuran,Nifuralazinum,NFT

Target: Others

GW311616 hydrochloride

Cat.No: T11525L

Synonym: GW311616A

Target: Others

Zanamivir-Cholesterol Conjugate

Cat.No: T40140

Target: Others

Cat.No: T33534

Synonym: Edrul,Muzolimina,Muzoliminum

Target: Others

Cat.No: T28567

Synonym: Ro-22-9194

Target: Others

Cat.No: T15269

Target: Others

Cat.No: T61685

Target: Others

Cat.No: T22315

Target: Others

[Phe8Ψ(CH-NH)-Arg9]-Bradykinin

Cat.No: TP2076

Cat.No: T61659

Target: Others

Cat.No: T71147

Target: Others

Cat.No: T28901

Synonym: 5,5-Diphenylbarbituric acid,DPB

Target: Others

AZD-9164 bromide

Cat.No: T26724

Synonym: AZD9164,AZD-9164,AZD 9164

Target: Others

Parapenzolate Free Base

Cat.No: T70473

Target: Others

Human enteropeptidase-IN-3

Cat.No: T82163

Target: Others

Cat.No: T70257

Target: Others

Cat.No: T80738

Synonym: Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone

Cat.No: T73910

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3S0081	Oxypeucedanin (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin	Potassium Channel	Membrane transporter/Ion channel
	Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物，分离自Angelica dahurica。它是选择性开放通道阻滞剂，可抑制hKv1.5通道电流，IC50值为 76 nM。它延长心脏动作电位持续时间，是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。

天然产物

Cat.No: T3S0081

Synonym: (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin

Target: Potassium Channel

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04483	IRAK4 Protein, Human, Recombinant (His) IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...	Human	Baculovirus Insect Cells
	Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ...
TMPJ-00848	NCF1 Protein, Human, Recombinant (His) Nox-organizing protein 2/SH3 and PX domain-containing protei...	Human	E. coli
	Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a membrane bound cytochrome b558 are required for the activation of the latent NADPH oxidase. The human NCF1 gene encodes a 390 amino acids protein without a signal peptide. The NCF1 gene interacts with other subunits of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) and ...
TMPY-02977	PDE1C Protein, Human, Recombinant (His & GST) hCam-3,phosphodiesterase 1C, calmodulin-dependent 70kDa,cam-...	Human	Baculovirus Insect Cells
	PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a s...
TMPY-04561	SGK3 Protein, Human, Recombinant (His & GST) serum/glucocorticoid regulated kinase family, member 3,SGK2,...	Human	Baculovirus Insect Cells
	Serine / threonine-protein kinase Sgk3, also known as Serum / glucocorticoid-regulated kinase 3, Serum / glucocorticoid-regulated kinase-like and SGK3, is a cytoplasmic vesicle protein that belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. SGK3 contains one AGC-kinase C-terminal domain, one protein kinase domain and one PX (phox homology) domain. Two specific sites of SGK3, one in the kinase domain (Thr-32) and the other in the C-terminal regulatory region (Ser-486...

重组蛋白

IRAK4 Protein, Human, Recombinant (His)

Cat.No: TMPY-04483

Species: Human

Expression System: Baculovirus Insect Cells

NCF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00848

Species: Human

Expression System: E. coli

PDE1C Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02977

Species: Human

Expression System: Baculovirus Insect Cells

SGK3 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04561

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0259	Bilastine-d6
	Bilastine-d6 是 Bilastine 的氘代化合物。Bilastine 的 CAS 号为 202189-78-4。Bilastine是新型抗组胺药，对H1组胺受体具有高度选择性，起效快，作用时间长的特性，可用于变应性鼻结膜炎和荨麻疹。
TMIJ-0260	Bilastine-d4
	Bilastine-d4 是 Bilastine 的氘代化合物。Bilastine 的 CAS 号为 202189-78-4。Bilastine是新型抗组胺药，对H1组胺受体具有高度选择性，起效快，作用时间长的特性，可用于变应性鼻结膜炎和荨麻疹。
T71145	Racecadotril-d5
	Racecadotril-d5 is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan. In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively. It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-indu...
TMIJ-0497	Lacidipine-d10
	Lacidipine-d10 是 Lacidipine 的氘代化合物。Lacidipine 的 CAS 号为 103890-78-4。Lacidipine 是一种L型钙离子通道阻断剂。
TMIH-0086	Amifampridine-d3 2HCl
	Amifampridine-d3 2HCl 是 Amifampridine 2HCl 的氘代化合物。Amifampridine 2HCl 的 CAS 号为 54-96-6。Amifampridine 可用于罕见肌肉疾病的研究。
TMIJ-0228	Lidocaine-d6 HCl
	Lidocaine-d6 HCl 是 Lidocaine HCl 的氘代化合物。Lidocaine HCl 的 CAS 号为 73-78-9。Lidocaine hydrochloride 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制MEK/ERK和NF-κB信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine 是一种酰胺衍生物，是一种研究室性心律失常的药物和有效的肿瘤抑制剂。
TMID-0263	Lidocaine-d10 Hydrochloride
	Lidocaine-d10 Hydrochloride 是 Lidocaine Hydrochloride 的氘代化合物。Lidocaine Hydrochloride 的 CAS 号为 73-78-9。Lidocaine hydrochloride 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制MEK/ERK和NF-κB信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine 是一种酰胺衍生物，是一种研究室性心律失常的药物和有效的肿瘤抑制剂。
TMID-0070	Amiodarone-d10 Hydrochloride
	Amiodarone-d10 Hydrochloride 是 Amiodarone Hydrochloride 的氘代化合物。Amiodarone Hydrochloride 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物，通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间，可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化，可研究室上性和室性心律失常。
TMID-0069	Amiodarone-d4 HCl
	Amiodarone-d4 HCl 是 Amiodarone HCl 的氘代化合物。Amiodarone HCl 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物，通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间，可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化，可研究室上性和室性心律失常。

同位素标记化合物

Cat.No: TMIJ-0259

Cat.No: TMIJ-0260

Racecadotril-d5

Cat.No: T71145

Cat.No: TMIJ-0497

Amifampridine-d3 2HCl

Cat.No: TMIH-0086

Lidocaine-d6 HCl

Cat.No: TMIJ-0228

Lidocaine-d10 Hydrochloride

Cat.No: TMID-0263

Amiodarone-d10 Hydrochloride

Cat.No: TMID-0070

Amiodarone-d4 HCl

Cat.No: TMID-0069

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