265
51
5
61
5
Cat. No. | Product Name | ||
---|---|---|---|
L6140 | 糖类及苷类化合物库 | 595 compounds | |
595 种糖类或苷类的化合物,可用于高通量筛选和高内涵筛选; | |||
L7300 | 钾通道分子库 | 152 compounds | |
152 种钾通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L7200 | 钙通道分子库 | 140 compounds | |
140 种钙通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L5510 | 肝脏毒性化合物库 | 1001 compounds | |
1001 个肝脏毒性化合物的特有集合,可用于高通量、高内涵筛选,是毒理学研究的良好工具; | |||
L7110 | 抗高血压化合物库 | 678 compounds | |
678 种高血压相关的小分子,用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T23351 |
Shz 1
|
Others | Others |
Shz-1在 P19CL6 细胞中诱导各种心脏特异性基因,包括肌节原肌球蛋白,在小鼠中诱导 Nkx2.5 表达。Shz-1 在 C2C12 细胞中激活轴突 TPM4 启动子驱动的异位表达。 | |||
T15052 |
Dapansutrile
|
NOD-like Receptor (NLR); NOD | Immunology/Inflammation; NF-κB |
Dapansutrile 是一种口服有活性的 NLRP3 炎性小体选择性抑制剂。它具有抗炎特性,可用于研究缓解疼痛。 | |||
T22341 |
GSK-114
|
Others | Others |
GSK 114 是口服有活性的、高选择性的TNNI3K 抑制剂 (IC50= 25 nM)。其中TNNI3K (又称 CARK) 是酪氨酸样激酶家族的成员,选择性在心脏组织中表达。它对 TNNI3K 的选择性是 B-Raf 激酶的 40 倍 (IC50= 1 µM)。 | |||
T1787 |
Levobupivacaine
|
Sodium Channel | Membrane transporter/Ion channel |
Levobupivacaine 是一种氨基酰胺类局麻药,属于n-alkylsubstituted pipecoloxylidide 家族。它是bupivacaine 的 S-对映异构体。 | |||
T9258 |
Aficamten
|
Others | Others |
Aficamten 是一种可研究肥厚型心肌病的新型心肌肌球蛋白抑制剂,IC50为 1.4 μM。 | |||
T8786 |
VUT-MK142
|
Others | Others |
VUT-MK142 是强效心肌合成剂,能够诱导心脏前中胚层向心肌细胞分化,促进干细胞向心肌细胞分化进行的心脏修复。 | |||
T0267 |
Zonisamide
AD 810,唑尼沙胺,CI 912 |
Calcium Channel; Sodium Channel; Carbonic Anhydrase | Membrane transporter/Ion channel; Metabolism |
Zonisamide (AD 810) 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂,对人类线粒体同工酶 hCA II 和 hCA V 作用的 Ki 值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性,在癫痫、癫痫发作和帕金森病的研究中具有价值。 | |||
T11807 |
L002
|
Others; Histone Acetyltransferase; STAT | Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells |
L002 是一种细胞可渗透的,可逆特定性乙酰转移酶 p300(KAT3B)抑制剂,IC50为 1.98 μM。 它结合乙酰辅酶 A 口袋并竞争性抑制 FATp300 催化结构域,阻断组蛋白乙酰化和 p53 乙酰化,且抑制 STAT3 激活,有用于高血压引起的心脏肥大和纤维化的研究潜力。 | |||
T2052 |
KY02111
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
KY02111 是典型的 WNT 信号抑制剂,能够促进人多潜能干细胞向心肌细胞分化,可用于研究人类心肌细胞再生。 | |||
T8391 |
Cesium chloride
氯化铯,CsCl |
Potassium Channel | Membrane transporter/Ion channel |
Cesium chloride (CsCl) 是一种钾通道抑制剂,可以防止 Alloxan 引起的 Na+转运减少。Cesium chloride 可以诱发心律失常。 | |||
T24109 |
GSK329
GSK 329,GSK-329 |
Others | Others |
GSK329 是一种有效的选择性 TNNI3 相互作用激酶 (TNNI3K) 抑制剂。 GSK329 在缺血/再灌注心脏损伤模型中表现出积极的心脏保护作用。 | |||
T9232 |
Mitochondrial fusion promoter M1
|
Mitochondrial Metabolism | Metabolism |
Mitochondrial fusion promoter M1 是一种线粒体动态调节剂,能够保持线粒体功能并促进细胞呼吸,减轻心肌缺血/再灌注大鼠的心脏损伤和大脑损伤。 | |||
T16686 |
Pyr10
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
Pyr10 是吡唑衍生物,是TRPC3通道的选择性抑制剂。Pyr10抑制卡巴可刺激的TRPC3转染的 HEK293 细胞中的 Ca2+流入。它具有区分受体操纵的TRPC3和天然基质相互作用分子 1 (STIM1)/Orai1 通道的能力。 | |||
T6086 |
Clopamide
Brinaldix,Adurix,Aquex,氯帕胺 |
Sodium Channel | Membrane transporter/Ion channel |
Clopamide (Brinaldix) 是口服有效的噻嗪类利尿剂,对钠耦合的氯离子共转运蛋白 SLC12A3有抑制作用。Clopamide 在高血压和心力衰竭中具有研究价值。 | |||
T1449 |
Hydrochlorothiazide
HCTZ,双氢氯噻嗪,氢氯噻嗪 |
Potassium Channel; Carbonic Anhydrase; TGF-beta/Smad | Membrane transporter/Ion channel; Metabolism; Stem Cells |
Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药,可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能,减少纤维化并具有降压作用。 | |||
T3144 |
BML-284
Wnt agonist 1 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
BML-284 (Wnt agonist 1) 是细胞通透性 Wnt 信号激活剂,能够诱导 TCF 依赖的转录活性(EC50>700 nM)。 | |||
T14782 |
Brilaroxazine
RP5063 |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Brilaroxazine (RP5063) 是一种有效的多模式多巴胺/5-HT 调节剂。 Brilaroxazine 是多巴胺 D2、D3 和 D4 受体、5-HT1A (Ki = 1.5 nM) 和 5-HT2A (Ki = 2.5 nM) 的部分激动剂,具有拮抗活性 5-HT2B 和 5-HT7 受体,Ki 分别为 0.19 nM 和 2.7 nM。 Brilaroxazine 可用于研究神经精神和神经系统疾病的认知障碍。 | |||
T15050 |
Danicamtiv
MYK-491,SAR 440181 |
Myosin | Cytoskeletal Signaling |
Danicamtiv (MYK-491) 是一种正性肌力药物,也是一种心肌肌球蛋白的选择性变构激活剂,可增加心脏收缩功能并保持机械效率。 | |||
T15207 |
Eleclazine hydrochloride
GS 6615 hydrochloride |
Sodium Channel | Membrane transporter/Ion channel |
Eleclazine hydrochloride (GS 6615 hydrochloride) 是新型 Na+电流抑制剂,IC50是0.7 uM。 | |||
T21454 |
Nicardipine
Cardene,Dagan,尼卡地平,Antagonil,Flusemide |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Nicardipine (Cardene) 是一种二氢吡啶类钙通道阻滞剂,可阻断心脏钙通道,IC50为 1 μM,可用于治疗心绞痛和高血压。 | |||
T15418 |
GS-6201
CVT-6883 |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
GS-6201 (CVT-6883) 是选择性腺苷 A2B 受体拮抗剂。它对人腺苷 A2B 受体具有高亲和力和选择性 (Ki=22 nM)。它降低了小鼠急性心肌梗死后心脏中 caspase-1 的活性,并减弱了心脏重塑。它减弱了致敏小鼠 NECA,AMP 或变应原诱导的气道反应性。 | |||
T20898 |
(R)-Propranolol hydrochloride
Dexpropranolol hydrochloride,(R)-(+)-Propranolol,盐酸普奈洛尔 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) 是一种抗肾上腺素受体拮抗剂,是一种普萘洛尔的活性较低的对映体。Dexpropranolol 是一种非选择性的β-adrenergic receptor 拮抗剂,对 β1AR 和 β2AR 具有高亲和力。 | |||
T12478L |
Pinacidil
吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134 |
Potassium Channel | Membrane transporter/Ion channel |
Pinacidil (P 1134) 是钾通道的有效激活剂。Pinacidil 通过打开 K+-通道使血管平滑肌超极化,显示出抗高血压活性。它显著改善再灌注功能和心脏顺应性。它具有直接的心脏保护作用。 | |||
T2176 |
2,3-Butanedione 2-Monoxime
Diacetyl monoxime,2,3-Butanedione-2-monoxime |
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
2,3-Butanedione 2-Monoxime (Diacetyl monoxime) 是一种肌球蛋白 ATP 酶(myosin ATPase) 抑制剂。它诱导肌质网 Ca2+释放,能够有效抑制骨骼肌和心肌收缩。 | |||
T8820 |
BML-284 hydrochloride
BML-284 HCL,Wnt agonist 1 HCL |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
BML-284 hydrochloride (Wnt agonist 1 HCL) 是细胞通透性 Wnt 信号激活剂。它能够诱导 TCF 依赖的转录活性(EC50>700 nM)。 | |||
T1676 |
Rosuvastatin
罗伐他汀,ZD 4522,瑞舒伐他汀 |
Potassium Channel; HMG-CoA Reductase; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Rosuvastatin (ZD 4522) 是一种抗血脂药,可竞争性抑制羟甲基戊二酰辅酶 A 还原酶,用于降低血浆胆固醇水平和预防心血管疾病。它降低低密度脂蛋白胆固醇、甘油三酯和 C-反应蛋白水平。它阻断人类醚-a-go-go 相关基因电流,IC50为 195 nM,延迟心脏复极化,延长动作电位持续时间和校正 QT 间期间隔。 | |||
T1056 |
Isoprenaline hydrochloride
NCI-c55630,Isoproterenol hydrochloride,Isoprenaline HCl,盐酸异丙肾上腺素 |
PI3K; Endogenous Metabolite; Adrenergic Receptor; PDE | GPCR/G Protein; Metabolism; Neuroscience; PI3K/Akt/mTOR signaling |
Isoprenaline hydrochloride (Isoproterenol hydrochloride) 是一种 β-肾上腺素能受体激动剂,具有非选择性和口服活性。Isoprenaline hydrochloride 可以扩张支气管,提高心率和心输出量,而不会收缩血管。 | |||
T3096 |
Canrenoate potassium
坎利酸钾,Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone |
Glucocorticoid Receptor | Endocrinology/Hormones |
Canrenoate potassium (Soldactone) 是一种有效的竞争性盐皮质激素受体 (mineralocorticoid receptor) 拮抗剂,是一种释放 canrenone 的前药。它作为一种利尿剂,用于高血压的研究。 | |||
T9245 |
TRPM4-IN-1
CBA,4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid |
TRP/TRPV Channel | Membrane transporter/Ion channel |
TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) 是一种有效的阳离子通道TRPM4选择性抑制剂,IC50为 1.5 μM。TRPM4-IN-1 在心脏病和前列腺癌中具有研究价值。 | |||
T6566 |
Levobupivacaine hydrochloride
Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,盐酸左布比卡因,(S)-(-)-Bupivacaine monohydrochloride |
Sodium Channel | Membrane transporter/Ion channel |
Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) 是有效的钠通道阻滞剂。 | |||
T1215 |
Nicardipine hydrochloride
盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride |
Calcium Channel; Adrenergic Receptor; AChR; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Nicardipine hydrochloride (YC-93 Hydrochloride) 是一种钙通道阻滞剂,IC50为 1 μM。它可阻断某些细胞壁中的钙离子并抑制冠状动脉和外周动脉的收缩,从而降低对氧气的需求心肌和减少动脉收缩和痉挛。它在临床上用作脑和冠状血管扩张剂。 | |||
T9010 |
IMM-H007
|
Others; AMPK | Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
IMM-H007 是一种新型降脂剂,可增加 abca1 蛋白的表达。 | |||
T1510 |
Rosuvastatin calcium
ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium,瑞舒伐他汀钙 |
Potassium Channel; HMG-CoA Reductase; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Rosuvastatin calcium (ZD4522) 是肝羟甲基戊二酰辅酶 A 还原酶的选择性和竞争性抑制剂,具有抗血脂活性。它降低成熟 hERG 的表达以及热休克蛋白 70 与 hERG 蛋白的相互作用,还降低低密度脂蛋白胆固醇、甘油三酯和 C-反应蛋白水平。它阻断人类醚-a-go-go 相关基因电流,延迟心脏复极化,来延长动作电位持续时间和校正 QT 间期间隔。 | |||
T9026 |
MEISi-2
Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide |
Others | Others |
MEISi-2 是 MEIS(造血干细胞自我更新的关键调控因子)选择性抑制剂。它可用于心脏损伤、造血问题、骨髓移植和癌症的研究。 | |||
T7134 |
Mavacamten
MYK-461,SAR439152 |
Myosin | Cytoskeletal Signaling |
Mavacamten (MYK-461) 是一种可口服的心肌肌球蛋白 ATP 酶抑制剂,在牛心脏和人心脏中的IC50值分别为 490和711 nM。 | |||
T25372 |
EMD57033
EMD-57033,(+)-EMD 57033,EMD 57033 |
Calcium Channel; Carbonic Anhydrase | Membrane transporter/Ion channel; Metabolism |
EMD57033是一种心脏肌钙蛋白C(cTnC)激活剂,是一种显性的Ca2+增敏剂。EMD57033通过与心脏/慢速骨骼肌钙蛋白C 异构体结合从而发挥促进心脏收缩的功能。 | |||
T10364 |
Arbutamine
GP 21213 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Arbutamine (GP 21213) 是一种新型非选择性β-肾上腺素受体激动剂,具有α-1-拟交感神经活性。Arbutamine 促进心脏应激,增加心率、心脏收缩力。Arbutamine 可用于研究心脏应激和冠状动脉疾病。 | |||
T11097 |
Drobuline hydrochloride
|
Others | Others |
Drobuline hydrochloride 是一种抗心律失常剂。 | |||
T29050 |
UK 66914
UK66914,UK-66914 |
Potassium Channel | Membrane transporter/Ion channel |
UK 66914 是一种 K(+)通道阻断剂,可用于研究心律失常。 | |||
T28686L |
SB-237376
|
Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
SB-237376 是一种钙和钾通道拮抗剂,可用于治疗心律失常。 | |||
T12078 |
ML334
LH601A |
Nrf2 | Immunology/Inflammation |
ML334 (LH601A) 是一种可穿过细胞膜且具有有效性的 NRF2 激活剂,抑制 Keap1-NRF2 蛋白质相互作用,抑制心脏成纤维细胞活化和增殖来改善心肌梗死诱导的心脏纤维化。 | |||
T28686 |
SB-237376 HCl
SB-237376 hydrochloride |
Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
SB-237376 HCl (SB-237376 hydrochloride) 是一种钙和钾通道拮抗剂,可用于治疗心律失常。 | |||
T24021 |
E 0747
E 747,L 29065,E0747,E-0747 |
Sodium Channel | Membrane transporter/Ion channel |
E 0747 (E0747) 是一种新的抗心律失常化合物,通过抑制心脏细胞的Na通道来抑制心律失常。 | |||
TP2058L |
Catestatin acetate
Catestatin acetate(142211-96-9 free base) |
Endogenous Metabolite; AChR | Metabolism; Neuroscience |
Catestatin acetate 是 nAChR 的非竞争性拮抗剂,可抑制儿茶酚胺的释放。 Catestatin acetate 调节心脏功能和血压。 | |||
T27630 |
Isbogrel
CV4151,CV-4151,CV 4151 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Isbogrel (CV4151)是一种小分子血栓素A2合成酶(TXA2 synthase)抑制剂,可用来研究心律失常、短暂性脑缺血发作和血栓形成。 | |||
T11239 |
Ethacizine hydrochloride
NIK-244,Ethacizin,NIK-244 hydrochloride |
Sodium Channel | Membrane transporter/Ion channel |
Ethacizine hydrochloride (NIK-244) 具有抗心律失常活性,其作用于心脏活动有关,可用于研究心律失常和心肌梗死。 | |||
T10813 |
Cilobradine hydrochloride
DK-AH 269 |
HCN Channel | Membrane transporter/Ion channel |
Cilobradine hydrochloride (DK-AH 269) 是一种 HCN 通道阻断剂。 | |||
T25701 |
Levosemotiadil
SD 3212,SA 3212 |
LDL; Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Levosemotiadil(SA 3212) 是一种新型钙拮抗剂,是一种非常有效的低密度脂蛋白氧化抑制剂。Levosemotiadil 可用于预防致死性心律失常。 | |||
T0294 |
6α-Methylprednisolone 21-hemisuccinate sodium salt
Asmacortone,Methylprodnisolone Sodium Succinate,甲强龙琥珀酸钠,Metypresol,Methylprednisolone sodium succinate,Corticel,6-Methylprednisolone succinate sodium |
Glucocorticoid Receptor; Glucagon Receptor | Endocrinology/Hormones; GPCR/G Protein |
6α-Methylprednisolone 21-hemisuccinate sodium salt (Asmacortone) 是一种糖皮质激素,是一种有效的抗炎剂,半衰期比 Prednisolone 长。 | |||
T12267 |
NSP-805
|
PDE | Metabolism |
NSP-805 是一种强心剂,是一种选择性的 phosphodiesterase 3 抑制剂,具有舒张血管的作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1754 |
Hypaconine
|
Others | Others |
Hypaconine 是一种 C19-二萜生物碱,从乌头和飞燕草属中分离出来得到。 它表现出强烈的心脏活性。 | |||
TN2054 |
Periplocymarin
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Periplocymarin 是一种强心苷,从 Periploca sepium 和 Periploca graeca 中分离得到,具有抗癌潜力。 | |||
T3408 |
Syringin
Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine,紫丁香苷 |
NOS; Autophagy | Autophagy; Immunology/Inflammation |
Syringin (eleutheroside-b) 是欧丁香中的一种苯丙素类天然产物,通过抑制自噬来防止压力超载引起的心肌肥厚,具有抗肿瘤、抗增殖、抗骨质疏松、免疫调节和血小板聚集抑制作用。 | |||
T3S0081 |
Oxypeucedanin
(+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin |
Potassium Channel | Membrane transporter/Ion channel |
Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物,分离自Angelica dahurica。它是选择性开放通道阻滞剂,可抑制hKv1.5通道电流,IC50值为 76 nM。它延长心脏动作电位持续时间,是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。 | |||
TN1039 |
Tamarixetin
柽柳黄素,4'-O-Methyl Quercetin |
Endogenous Metabolite; Immunology/Inflammation related | Immunology/Inflammation; Metabolism |
Tamarixetin (4'-O-Methyl Quercetin) 是一种槲皮素的天然类黄酮衍生物,具有抗氧化、抗炎作用,能够防止心肌肥厚。 | |||
TN5073 |
Strophanthidin
毒毛旋花子甙元,Strophanthidine,葡萄球菌素 |
ATPase; Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Strophanthidin (Strophanthidine) 是黄花夹竹桃中的一种类固醇,可增加舒张期和收缩期胞内 Ca2+浓度。它在 0.1 和 1 nmol/L 增加Na+/K+-ATPase 活性,1到100 μ mol/L 抑制Na+/K+-ATPase 活性,10 和 100 nmol/L 对Na+/K+-ATPase 活性无影响。 | |||
T8183 |
Deslanoside
洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C |
ATPase; Drug Metabolite | Membrane transporter/Ion channel; Metabolism |
Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷,可抑制Na-K-ATPase 膜泵,导致细胞内钠和钙浓度增加。它用于研究充血性心力衰竭和因折返机制引起的室上性心律失常,并在研究慢性心房颤动时控制心室率。 | |||
T5247 |
Trimethylamine N-oxide dihydrate
二水氧化三甲胺,TMANO Dihydrate |
Others; Endogenous Metabolite | Metabolism; Others |
Trimethylamine N-oxide dihydrate (TMANO Dihydrate) 是内源性代谢产物的一种。 | |||
T3212 |
Digoxigenin
地谷新配基,异羟基洋地黄毒苷元 |
Others | Others |
Digoxigenin, a therapeutic drug belonging to the group of cardiac glycosides, is widely used in the management of congestive heart failure and other cardiac diseases | |||
T19466 |
N8-Acetylspermidine dihydrochloride
N8-乙酰基亚精胺二盐酸盐 |
Endogenous Metabolite | Metabolism |
N8-Acetylspermidine dihydrochloride 是一种多胺物质。 | |||
T1670 |
Lanatoside C
Cedilanid,Ceglunate,Isolanid,毛花甙丙,毛花苷C |
ATPase; Virus Protease; Autophagy | Autophagy; Membrane transporter/Ion channel; Microbiology/Virology |
Lanatoside C (Ceglunate) 是一种可用于治疗充血性心力衰竭和心律失常的强心苷类药物。它作用于 HuH-7细胞,可抗登革病毒感染, IC50为0.19 μM。 | |||
T5665 |
Geraniol
|
Others; Endogenous Metabolite; Antifungal | Metabolism; Microbiology/Virology; Others |
Geraniol 对糖尿病引起的心脏功能障碍起保护作用,抑制氧化应激。 | |||
TN1594 |
DL-Syringaresinol
(±)-Syringaresinol |
Antioxidant; Antifungal | Microbiology/Virology; oxidation-reduction |
DL-Syringaresinol ( (±)-Syringaresinol) 是一种来自与人参浆果的木质素,具有抗炎、抗氧化、镇痛活性和较弱的抗分枝杆菌活性。DL-Syringaresinol 可通过自噬延缓氧化应激诱导的皮肤老化,通过抑制炎症反应来缓解奥沙利铂诱导的神经性疼痛和脓毒症引起的心功能障碍。 | |||
TN1984 |
Neoisoliquiritin
|
Others | Others |
Neoisoliquiritin 是一种提取自甘草中的活性物质。 | |||
T5217 |
2-(2-Phenylacetamido)acetic acid
Phenaceturic acid,Phenyl-ac-Gly-OH,苯乙酰甘氨酸,Phenylacetyl glycine |
Others; Endogenous Metabolite | Metabolism; Others |
Phenyl-ac-Gly-OH 是内源性代谢产物的一种,可激活 β2AR,可用于研究缺血/再灌注引起的心脏损伤。 | |||
TN2430 |
Glucodigifucoside
洋地黄毒苷元葡萄糖基岩藻糖苷,洋地黄 |
||
Glucodigifucoside 是可从洋地黄种子中分离得到的强心苷,对人肾腺癌细胞有特异性细胞毒性。 | |||
TCO2745 |
Cyclic AMP
Adenosine 3',5'-cyclophosphate,cAMP,腺苷环磷酸酯,环磷腺苷,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate |
Others; Endogenous Metabolite | Metabolism; Others |
Cyclic AMP (cAMP)(Adenosine 3',5'-cyclophosphate) 是有丝分裂信使,可以促进 G1期到 S 期的细胞周期进程。 | |||
T2750 |
Ginkgolide C
银杏内酯C,BN-52022 |
MMP; Sirtuin; Endogenous Metabolite; AMPK | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ginkgolide C (BN-52022) 是从银杏叶中分离到的一种黄酮类天然产物,可增强体内大鼠的心脏功能,具有减少血小板聚集,改善阿尔兹海默症等作用。 | |||
T5940 |
Proxyphylline
羟丙茶碱,7-(2-Hydroxypropyl)theophylline |
PDE; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Proxyphylline (7-(2-Hydroxypropyl)theophylline) 是甲基黄嘌呤衍生物,可用作心脏活化剂、血管扩张剂和支气管扩张剂。 | |||
T8195 |
Lotusine
|
Others | Others |
Lotusine 是一种提取自Nelumbo nucifera Gaertn 的绿色种胚中的纯生物碱。它能够作用于心肌中动作电位及心脏浦肯野纤维缓慢内向电流。 | |||
T5968 |
DL-Homocysteine thiolactone hydrochloride
DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐 |
Endogenous Metabolite | Metabolism |
DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) 是具有根生长抑制特性的环状氨基酸衍生物。 | |||
T4550 |
Ajmaline
Cardiorythmine,Raugalline,阿义吗啉,阿义马林,Tachmalin,(+)-Ajmaline |
Sodium Channel | Membrane transporter/Ion channel |
Ajmaline (Cardiorythmine) 是一种钠通道阻断剂,属于1A 类抗心律失常剂。Ajmaline 阻断 HERG 电流,在 HEK 细胞的 IC50为 1 μM,爪蟾卵母细胞的IC50为 42.3 μM。Ajmaline 在室性心动过速方面具有研究价值。 | |||
T1083 |
Theophylline
Theo-24,1,3-Dimethylxanthine,茶碱 |
Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物,具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。 | |||
TN1923 |
Mesaconine
|
IL Receptor; NF-κB | Immunology/Inflammation; NF-κB |
Mesaconine 是来自 Aconitum carmichaelii Debx 的一种成分。Mesaconine 具有心脏作用和抗 NF-κB 活性。 Mesaconine 可能是麻黄附子细辛汤抗炎和免疫抑制的部分物质基础。 | |||
T5S1708 |
Dendrobine
|
Others; Influenza Virus | Microbiology/Virology; Others |
Dendrobine 是从石斛中分离的一种生物碱,对甲型流感病毒具有抗病毒活性。 | |||
T0266 |
Quinidine hydrochloride monohydrate
奎宁树,奎尼丁盐酸盐一水合物,奎尼丁盐酸盐,Quinidine hydrochloride |
Potassium Channel; Sodium Channel; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
Quinidine hydrochloride monohydrate 是一种抗心律失常剂,也是 K+通道 (K+channel) 的有效阻断剂,其IC50值为 19.9 μM。它是一种有效且选择性的细胞色素 P450db (cytochrome P450db) 抑制剂,也可用作疟疾的研究。 | |||
T3921 |
Punicalagin
安石榴甙,安石榴苷 |
SARS-CoV; HBV | Microbiology/Virology |
Punicalagin 是一种在石榴中发现的主要鞣花单宁,是可逆且非竞争性的 3CLpro 抑制剂。Punicalagin 具有抗氧化、抗炎和抗肿瘤活性。 | |||
T41245 |
Trimethylamine N-oxide
|
Reactive Oxygen Species; NOD-like Receptor (NLR); TGF-beta/Smad | Immunology/Inflammation; Metabolism; NF-κB; Stem Cells |
Trimethylamine N-oxide (TMAO) 是由胆碱、甜菜碱和肉碱通过肠道微生物代谢产生的一种无色氧化胺,积聚在海洋动物的组织中,可预防尿素对蛋白质的破坏作用。Trimethylamine N-oxide 通过激活 ROS/NLRP3 炎性体诱导炎症,可诱导纤维细胞的分化和心脏纤维化。 | |||
T2S1008 |
Oxysophoridine
Sophoridine N-oxide,氧化槐定碱 |
Apoptosis; Antioxidant | Apoptosis; oxidation-reduction |
Oxysophoridine (Sophoridine N-oxide) 是从苦豆子中提取的一种生物碱,具有抗发炎,抗氧化应激和抗凋亡的作用。 | |||
T3S0629 |
Delsoline
Belsoline,硬飞燕草碱 |
Others | Others |
Delsoline (Belsoline) 是一种还亮草的主要生物碱,具有类似箭毒的效果和神经节阻滞作用,可用于肌肉紧张或运动过度的缓解。其中还亮草具有祛风除湿,止痛,活络的功效,可用于风湿,偏瘫,消化不良和咳嗽的研究。 | |||
T5S0890 |
Oleandrin
Neriostene,Folinerin,Foliandrin,欧夹竹桃苷 |
Apoptosis; ATPase; Potassium Channel; Sodium Channel | Apoptosis; Membrane transporter/Ion channel |
Oleandrin (Folinerin) 是夹竹桃属中的一种类固醇,可抑制Na+/K+-ATPase 活性,IC50为 620 nM。 | |||
T4A2399 |
Cinobufotalin
华蟾毒它灵,华蟾素 |
IL Receptor; Akt; MRP; P-gp | Cytoskeletal Signaling; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; PI3K/Akt/mTOR signaling |
Cinobufotalin 是一种从蟾蜍的皮肤分泌物中提取的强心类固醇或丁二烯内酯。它已被用作强心药,利尿药和止血药,也是潜在的抗肺癌药物。 | |||
T3753 |
Sinapinic Acid
Sinapic acid,芥子酸,Synapoic acid |
Apoptosis; RAAS; Reactive Oxygen Species; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB |
Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类,是HDAC 抑制剂,对ACE-I 的活性也有抑制作用。它有抗肿瘤活性,诱导肿瘤细胞凋亡,具有抗氧化、抗糖尿病的作用。 | |||
T3893 |
Forsythoside B
连翘酯苷 B,连翘脂苷B |
TNF; NF-κB | Apoptosis; NF-κB |
Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha,IL-6,IκB, 调节 NF-κB。它抑制炎症反应,具有抗氧化和神经保护作用。 | |||
T2S2215 |
Crebanine
|
Apoptosis; Others; Akt | Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling |
Crebanine 是来自于韦诺萨千金藤的一种生物碱,通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性,还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。 | |||
TN5289 |
Thevebioside
Digitoxigenin glucosylthevetoside |
||
Thevebioside and digitoxin are cardiac glycosides, have cardiac action. | |||
T16332 |
NKH477
Colforsin dapropate hydrochloride |
NMDAR | Neuroscience |
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 shows an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute | |||
T10554 |
Bixin
|
Others | Others |
Bixin is isolated from the seeds of Bixa orellana and possesses anti-tumor, anti-inflammatory, and antioxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation, and ROS generation. | |||
TN4949 |
Sarmentocymarin
|
Others | Others |
Sarmentocymarin is a cardiac glucoside. | |||
TN1367 |
Alismol
泽泻醇 |
Potassium Channel; Calcium Channel; PI3K | Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks. | |||
TN1797 |
Isorhoifolin
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Isorhoifolin and vicenin II are main compounds of ethyl acetate fraction (EAcF) obtained from Erythrina velutina leaves, EAcF increases the cardiac contractile force by increasing the l-type calcium current and activating the adrenergic receptor pathway. | |||
T11513 |
Gum arabic
Arabic gum,阿拉伯胶 |
Others | Others |
Gum Arabic, a branched-chain, complex polysaccharide derived from A. Senegal, exhibits antioxidant properties and offers protection against experimental hepatic, renal, and cardiac toxicities. Additionally, it finds application in immunohistochemistry. | |||
TN1912 |
Marinobufogenin
南美蟾毒精,Marinobufagenin |
ATPase; EGFR | Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors |
Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure. | |||
TN5141 |
Thevetin B
|
ATPase; Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Thevetin B 是一种强心苷,是Na+-, K+-依赖性腺苷三磷酸酶 (Na+,K+-ATPase) 的抑制剂,来自 Thevetia peruviana。 | |||
T83454 |
13-Hydroxylupanine hydrochloride
Hydroxylupanine hydrochloride |
||
13-Hydroxylupanine是甜羽扇豆中一种典型的生物碱。它具有阻断神经节传递、降低心肌收缩力以及收缩子宫平滑肌的作用。 | |||
T80702 |
α-Thevetin B
|
||
α-Thevetin B(Compound 24), 一种从Thevetia peruviana分离得到的心脏苷,用于肺癌、胃癌和胰腺癌的研究。 | |||
T79982 |
2'-epi-2'-O-Acetylthevetin B
GHSC-74 |
Apoptosis | Apoptosis |
2'-epi-2'-O-Acetylthevetin B (GHSC-74) 为源自Cerbera manghas L种子的强心苷,其抑制HepG2细胞增殖并诱导细胞凋亡(apoptosis)及线粒体膜电位降低。 | |||
T78489 |
Lotusine hydroxide
|
Others | Others |
Lotusine (hydroxide)为纯生物碱,源自Nelumbo nucifera Gaertn绿色种胚提取。该化合物能够影响心肌动作电位和心脏浦肯野纤维的缓慢内向电流。 | |||
T82782 |
Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside
|
||
Cannogenol 3-O-β-gentiobisyl-(1→4)-α-L-thevetoside (Compound 12) 是从Thevetia peruvian的种子中分离得到的强心苷化合物。它对SW1990和MGC-803细胞表现出细胞毒性,其IC50分别为9.52 μM和7.70 μM。 | |||
TN1162 |
Dibutyl phthalate
1,2-Benzenedicarboxylic acid |
Antifection | Microbiology/Virology |
Dibutyl phthalate (1,2-Benzenedicarboxylic acid) 是一种增塑剂,常见于工业制造,通过破坏从内质网到线粒体的 Ca(2+) 转移并引发随后的细胞焦亡而引起心脏损伤。Dibutyl phthalate 在斑马鱼大脑中诱导氧化损伤。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01049 |
Cardiac phospholamban/PLN Protein, Human, Recombinant (GST)
Cardiac phospholamban,PLN,PLB |
Human | P. pastoris (Yeast) |
Cardiac phospholamban/PLN Protein, Human, Recombinant (GST) is expressed in yeast with N-GST tag. The predicted molecular weight is 33.1 kDa and the accession number is P26678. | |||
TMPH-02954 |
TNNI3 Protein, Mouse, Recombinant (His & SUMO)
Cardiac troponin I,Troponin I, cardiac mus... |
Mouse | E. coli |
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TNNI3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 40.1 kDa and the accession number is P48787. | |||
TMPH-03393 |
TnTc Protein, Rat, Recombinant (His)
Troponin T, cardiac muscle,Cardiac muscle ... |
Rat | E. coli |
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TnTc Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 41.6 kDa and the accession number is P50753. | |||
TMPH-01730 |
MYBPC3 Protein, Human, Recombinant (His & SUMO)
C-protein, cardiac muscle isoform,Myosin-binding pr... |
Human | E. coli |
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. MYBPC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 50.8 kDa and the accession number is Q14896. | |||
TMPH-01176 |
CSRP3 Protein, Human, Recombinant (His & SUMO)
CLP,CRP,Muscle LIM protein,CSRP3,Cardiac LIM protei... |
Human | E. coli |
CSRP3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-01727 |
Myosin-6/MYH6 Protein, Human, Recombinant (His)
Myosin heavy chain 6,Myosin heavy chain, cardiac mu... |
Human | P. pastoris (Yeast) |
Muscle contraction. Myosin-6/MYH6 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 76.8 kDa and the accession number is P13533. | |||
TMPH-01728 |
Myosin-6/MYH6 Protein, Human, Recombinant (E. coli, His)
Myosin-6,MYH6,Myosin heavy chain, cardiac muscle al... |
Human | E. coli |
Muscle contraction. Myosin-6/MYH6 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 80.8 kDa and the accession number is P13533. | |||
TMPH-00780 |
CACNA1C Protein, Guinea Pig, Recombinant (His)
CACNA1C,CACNL1A1,CACH2,CACN2,Voltage-dependent L-type calciu... |
Guinea pig | E. coli |
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressur... | |||
TMPH-01725 |
MYL3 Protein, Human, Recombinant (GST)
Ventricular myosin alkali light chain,Ventricular/slow twitc... |
Human | E. coli |
Regulatory light chain of myosin. Does not bind calcium. MYL3 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 48.8 kDa and the accession number is P08590. | |||
TMPY-04552 |
AKT1 Protein, Human, Recombinant (His)
RAC-ALPHA,v-akt murine thymoma viral oncogene homolog 1,RAC,... |
Human | Baculovirus Insect Cells |
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac... | |||
TMPJ-00261 |
TGF beta 2 Protein, Mouse/Rat, Recombinant
transforming growth factor β-2,BSC-1 cell growth inhibitor,G... |
Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n... | |||
TMPY-00117 |
FGF-16 Protein, Human, Cynomolgus, Recombinant
fibroblast growth factor 16 |
Human,Cynomolgus | Baculovirus Insect Cells |
Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of ... | |||
TMPY-05004 |
FGF-4 Protein, Human, Recombinant
HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,HST,HBGF-4 |
Human | E. coli |
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a... | |||
TMPY-00566 |
CCL18 Protein, Human, Recombinant (His)
PARC,CCL18,CKb7,DC-CK1,chemokine (C-C motif) ligand 18,MIP-4... |
Human | P. pastoris (Yeast) |
CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. CCL18 chemokine has an important role in chemokine-mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. (CCL18) is predominantly secreted by M2-tumor associated macrophages (TAMs) a... | |||
TMPJ-00044 |
TNNC1 Protein, Human, Recombinant (His)
TNNC1,Troponin I,CMH7,TNNI3 |
Human | E. coli |
Troponin I, also known as TNI, is a 24 kDa component of a protein complex on striated muscle thin filaments.Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Troponin I inhibits the calcium-dependent muscle contraction mediated by Troponins... | |||
TMPK-01369 |
S100B Protein, Canine, Recombinant (hFc)
S100 calcium-binding,S100-B,100β,100beta,NEF,Protein S100,S1... |
Canine | HEK293 Cells |
S100B, a calcium-binding protein of the EF-hand type exerts both intracellular and extracellular functions.The intracellular, and extracellular, roles of S100B are attractive therapeutic targets for the treatment of both cardiac and vascular disease. | |||
TMPH-01231 |
DIP2A Protein, Human, Recombinant (His)
DIP2A,DIP2,Disco-interacting protein 2 homolog A,C21orf106,D... |
Human | Baculovirus Insect Cells |
Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes. | |||
TMPH-01230 |
DIP2A Protein, Human, Recombinant (hFc)
DIP2 homolog A,Disco-interacting protein 2 homolog A,KIAA018... |
Human | HEK293 Cells |
Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes. | |||
TMPJ-00785 |
FABP3 Protein, Human, Recombinant (His)
H-FABP,FABP11,Fatty Acid-Binding Protein Heart,MDGIMuscle Fa... |
Human | E. coli |
Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, FABP3 is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-types. They form 14-15 kDa proteins and are thought to p... | |||
TMPK-01286 |
MMP-8 Protein, Cynomolgus, Recombinant (His)
Collagenase 2,HNC,CLG1,MMP8,PMNL-CL |
Cynomolgus | HEK293 Cells |
Alteration of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) expression has been studied for various cardiac diseases, including dilated cardiomyopathy (DCM), with the significance of surrogate markers of extracellular matrix (ECM) remodeling. MMP-8 was identified only in myocardiocytes, while MMP-9 and TIMP-2 were present in both myocardiocytes and stroma, but with different intensity. The increasing intensity of MMP-8 and TIMP-2 immunoreactions was signifi... | |||
TMPH-00286 |
Myotrophin Protein, Bovine, Recombinant (His)
MTPN,Myotrophin |
Bovine | P. pastoris (Yeast) |
Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Myotrophin Protein, Bovine, Recombinant (His) is expressed in yeast with N-10xHis tag. The predicted molecular weight is... | |||
TMPJ-00875 |
NPPB Protein, Human, Recombinant (His)
NPPB,γ-Brain Natriuretic Peptide,Gamma-Brain Natriuretic Pep... |
Human | E. coli |
Human Natriuretic peptides B acts as a cardiac hormone; it is associated with many biological actions, such as diuresis, natriuresis, vasorelaxation, which inhibits the secretion of rennin and aldosterone. It acts as a paracrine antifibrotic factor in the heart. Natriuretic peptides B can help restore the body balance of salt and water, improves the heart function. Natriuretic peptides B binds and stimulates the cGMP production of the NPR1 receptor and binds the clearance receptor NPR3. | |||
TMPH-02103 |
SRF Protein, Human, Recombinant (His)
SRF,Serum response factor |
Human | P. pastoris (Yeast) |
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupli... | |||
TMPJ-00882 |
Desmin Protein, Human, Recombinant (His)
DES,Desmin |
Human | E. coli |
Desmin is a cytoplasmic protein and belongs to the intermediate filament family. interacts with DST and MTM1. Desmin is only expressed in vertebrates, however homologous proteins are found in many organisms. Desmin is the main intermediate filament in mature skeletal, cardiac and smooth-muscle cells. DES founctions as homopolymers to form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. .Defects in DES are cause of the myopathy myofibr... | |||
TMPJ-00753 |
Myoglobin Protein, Human, Recombinant (His)
MGC13548,PVALB,MB,Myoglobin |
Human | E. coli |
Myoglobin(MB) is a cytoplasmic protein expressed in myocytes of the heart and skeletal muscle that reversibly binds oxygen. It belongs to the globin family. Functions of myoglobin include oxygen storage and transport, as well as scavenging of NO and reactive oxygen species. MB serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Myoglobin also serves as a sensitive marker for muscle injury resulting from cardiac infarction. Surprisingly, mice in which myogl... | |||
TMPJ-01364 |
LMCD1 Protein, Human, Recombinant (His)
LMCD1,Dyxin,LIM and cysteine-rich domains protein 1 |
Human | E. coli |
LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critic... | |||
TMPH-02634 |
TRIM63 Protein, Mouse, Recombinant (His & Myc)
Trim63,Muscle-specific RING finger protein 1,Tripartite moti... |
Mouse | E. coli |
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate... | |||
TMPK-01048 |
Aggrecan Protein, Human, Recombinant (His)
CSPG1,MSK16,AGC1,ACAN |
Human | HEK293 Cells |
Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of joints where they ensure adequate load-bearing. In the brain, they provide mechanical buffering and contribute to formation of perineuronal nets, which regulate synaptic plasticity. Aggrecan is also present in cardiac jelly, developing heart valves, and blood vess... | |||
TMPJ-00190 |
CD38 Protein, Mouse, Recombinant (hFc)
ADP-ribosyl cyclase 1,cyclic ADP-ribose hydrolase,T10,CD38 |
Mouse | HEK293 Cells |
CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Th... | |||
TMPH-01271 |
TRIM63 Protein, Human, Recombinant (His & Myc)
TRIM63,Striated muscle RING zinc finger protein,RING-type E3... |
Human | E. coli |
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate... | |||
TMPJ-01195 |
BTNL9 Protein, Human, Recombinant (His)
BTNL9,Butyrophilin-like protein 9 |
Human | HEK293 Cells |
Butyrophilin-Like Protein 9 (BTNL9) is single-pass type I membrane protein member of the BTN/MOG family that belongs to the immunoglobulin superfamily. BTNL9 consists of two domains: one B30.2/SPRY domain and one Ig-like V-type (immunoglobulin-like) domain. Human BTNL9 mRNA has been identified in adipose, lung, thymus, spleen, colon, and cardiac tissues, but its highest levels of expression were found in B cells. BTNL9 expression has also been found to be down-regulated in colon cancer tumors. B... | |||
TMPJ-01194 |
BTNL9 Protein, Human, Recombinant (hFc)
BTNL9,Butyrophilin-like protein 9 |
Human | HEK293 Cells |
Butyrophilin-Like Protein 9 (BTNL9) is single-pass type I membrane protein member of the BTN/MOG family that belongs to the immunoglobulin superfamily. BTNL9 consists of two domains: one B30.2/SPRY domain and one Ig-like V-type (immunoglobulin-like) domain. Human BTNL9 mRNA has been identified in adipose, lung, thymus, spleen, colon, and cardiac tissues, but its highest levels of expression were found in B cells. BTNL9 expression has also been found to be down-regulated in colon cancer tumors. B... | |||
TMPY-03600 |
TPM4 Protein, Human, Recombinant (His)
tropomyosin 4,HEL-S-108,TPM4 |
Human | HEK293 Cells |
TPM4, also known as tropomyosin 4, is a member of the tropomyosin family. Members of this family are actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM4 is expressed in cardiac tissue and platelets. It is highly expressed in the platelets of hypertensive patients. TPM4 plays a central role, in association with the troponin complex, in the calcium-dependent regulation of vertebrate striated muscle contraction. Smo... | |||
TMPH-03282 |
TRIM63 Protein, Rat, Recombinant (His & Myc)
Muscle-specific RING finger protein 1,Tripartite motif-conta... |
Rat | E. coli |
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate... | |||
TMPJ-00086 |
CT-1 Protein, Human, Recombinant (His)
CTF1,CT-1,Cardiotrophin-1 |
Human | E. coli |
Cardiotrophin-1, also known as CT-1 and CTF1, is a member of the IL-6 superfamily. It is a sreted cytokine that is expressed in heart, skeletal muscle, prostate and ovary, and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and... | |||
TMPJ-01209 |
BTNL9 Protein, Mouse, Recombinant (hFc)
BTNL9,Butyrophilin-like protein 9 |
Mouse | HEK293 Cells |
Butyrophilin-Like Protein 9 (BTNL9) is single-pass type I membrane protein member of the BTN/MOG family that belongs to the immunoglobulin superfamily. BTNL9 consists of two domains: one B30.2/SPRY domain and one Ig-like V-type (immunoglobulin-like) domain. Human BTNL9 mRNA has been identified in adipose, lung, thymus, spleen, colon, and cardiac tissues, but its highest levels of expression were found in B cells. BTNL9 expression has also been found to be down-regulated in colon cancer tumors. B... | |||
TMPJ-00931 |
Serpin A4 Protein, Human, Recombinant (His)
Kallistatin,Peptidase Inhibitor 4,KST,Kallikrein Inhibitor,S... |
Human | HEK293 Cells |
Serpin Peptidase Inhibitor, Clade A (α-1 Antiproteinase, Antitrypsin), Member 4 (Serpin A4) is a member of the Serpin family. Serpin A4 exists as a monomer and some homodimers. Serpin A4 is expressed by the liver and secreted in plasma. Serpin A4 is a regulator of vascular homeostasis capable of controlling a wide spectrum of biological actions in the cardiovascular and renal systems. It can inhibit intracellular reactive oxygen species formation in cultured cardiac and renal cells. In addition,... | |||
TMPJ-00553 |
Lp-PLA2/PLA2G7 Protein, Human, Recombinant (aa 22-441, His)
PAF Acetylhydrolase,LDL-Associated Phospholipase A2,LDL-PLA(... |
Human | HEK293 Cells |
Platelet-Activating Factor Acetylhydrolase (PAFAH) is a secreted enzyme which belongs to the AB hydrolase superfamily and Lipase family and catalyzes the degradation of platelet-activating factor to biologically inactive products. PAFAH is produced by inflammatory cells and hydrolyzes oxidised phospholipids in LDL. PAFAH has been implicated in the development of atherosclerosis and has also been identified as a marker for cardiac disease. PAFAH might have a major physiologic effect in the presen... | |||
TMPJ-00790 |
GSN Protein, Human, Recombinant (mFc)
ADF,Actin-depolymerizing factor,Brevin,Gelsolin,GSN,AGEL |
Human | HEK293 Cells |
Gelsolin is a calcium-activated actin filament severing and capping protein found in many cell types and as a secreted form in the plasma of vertebrates. Gelsolin is composed of six of these domains, termed G1-6. Some reaseraches show that gelsolin can act as a transcriptional cofactor in signal transduction and its own expression and function can be influenced by epigenetic changes. The difference in the expression levels of cytoplasmic and plasma gelsolin suggests that these two different form... | |||
TMPY-03456 |
SRFBP1 Protein, Human, Recombinant (His & GST)
STRAP,BUD22,P49,serum response factor binding protein 1,p49/... |
Human | Baculovirus Insect Cells |
SRFBP1 contains 7 WD repeats and belongs to the WD repeat STRAP family. SRFBP1 may play a role in the cellular distribution of the SMN complex. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. SRFBP1 negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. SRF... | |||
TMPJ-01112 |
PRKG1 Protein, Human, Recombinant (His)
PRKGR1B,PRKG1B,cGKI,cGMP-Dependent Protein Kinase 1,cGK1,cGK... |
Human | HEK293 Cells |
cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one protein kinase domain. PRKG1 is mainly expressed in the lung and placenta. PRKG1 acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. PRKG1 can phosphorylate many proteins that regulate platelet activation and adhesion, smooth muscle contraction, cardiac function,... | |||
TMPJ-01126 |
RheB Protein, Human, Recombinant (GST)
RHEB,Ras Homolog Enriched in Brain,GTP-Binding Protein Rheb,... |
Human | E. coli |
GTP-Binding Protein Rheb (RHEB) is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. Highest levels of RHEB can be found in the skeletal and cardiac muscle, and it is vital in the regulation of growth and cell cycle progression due to its role in the Insulin/TOR/S6K signaling pathway. RHEB stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling, and it activates... | |||
TMPJ-00402 |
CD117 Protein, Human, Recombinant (hFc)
KIT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog... |
Human | HEK293 Cells |
C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing sti... | |||
TMPU-00002 |
SOS1-Cat Protein, Human, Recombinant (His)
SOS-1,Son of sevenless homolog 1 |
Human | E. coli |
Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition. Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incid... | |||
TMPJ-00091 |
G-CSF Protein, Mouse, Recombinant (His)
Csf3,G-CSF,Granulocyte colony-stimulating factor,集落刺激因子 |
Mouse | HEK293 Cells |
Granulocyte colony-stimulating factor (G-CSF) is a growth factor and an essential cytokine which belongs to the IL-6 superfamily. Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. G-CSF binding to its receptor G-CSF-R which belongs to the cytokine receptor type I family depends on the interaction of ... | |||
TMPY-02708 |
NRG4 Protein, Human, Recombinant
HRG4,neuregulin 4 |
Human | E. coli |
NRG4 (neuregulin 4) is a member of the neuregulin protein family. The neuregulins consist of four structurally-related proteins that are part of the EGF family of proteins. It has been shown that these proteins have diverse functions in the development of the nervous system and play multiple essential roles in vertebrate embryogenesis including cardiac development, Schwann cell, and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular s... | |||
TMPH-01280 |
EGLN1 Protein, Human, Recombinant (His & Myc)
HPH-2,EGLN1,PHD2,SM-20,HIF-prolyl hydroxylase 2,HIF-PH2,C1or... |
Human | E. coli |
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquiti... | |||
TMPH-02222 |
TEAD1 Protein, Human, Recombinant (His)
TEAD1,Transcriptional enhancer factor TEF-1,Transcription fa... |
Human | E. coli |
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr... | |||
TMPY-02977 |
PDE1C Protein, Human, Recombinant (His & GST)
hCam-3,phosphodiesterase 1C, calmodulin-dependent 70kDa,cam-... |
Human | Baculovirus Insect Cells |
PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a s... | |||
TMPJ-01158 |
ALK-2/ACVR1 Protein, Human, Recombinant (hFc)
ACVRLK2,FOP,Activin RIA,ACTRI,ALK-2,activin A receptor, type... |
Human | HEK293 Cells |
Activin RIA, also known as ALK-2, TSK-7L, SKR1, TSR-I, and ACTR-I, is a glycosylated 65 kDa type I receptor in the TGF-beta serine/threonine kinase receptor family. Binding of TGF-beta superfamily ligands induces formation of a heterotetrameric complex that contains two chains each of a type I and a type II receptor in multiple combinations. The type II receptors phosphorylate the type I receptors which then phosphorylate and activate Smad signal transduction proteins. Activin RIA functions in a... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMID-0010 |
Mavacamten-d6
|
||
Mavacamten-d6 是 Mavacamten 的氘代化合物。Mavacamten 的 CAS 号为 1642288-47-8。MYK-461 是一种可口服的心肌肌球蛋白 ATP 酶抑制剂,在牛心脏和人心脏中的IC50值分别为 490和711 nM。 | |||
T10229 |
Acebutolol D7
|
Others | Others |
Acebutolol D7 is a deuterium-labeled Acebutolol. Acebutolol is a selective antagonist of the β1 adrenergic receptor used in the treatment of angina pectoris, hypertension, and cardiac arrhythmias. | |||
TMIJ-0228 |
Lidocaine-d6 HCl
|
||
Lidocaine-d6 HCl 是 Lidocaine HCl 的氘代化合物。Lidocaine HCl 的 CAS 号为 73-78-9。Lidocaine hydrochloride 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制MEK/ERK和NF-κB信号通路来减少胃癌细胞的生长,迁移和侵袭。Lidocaine 是一种酰胺衍生物,是一种研究室性心律失常的药物和有效的肿瘤抑制剂。 | |||
TMID-0263 |
Lidocaine-d10 Hydrochloride
|
||
Lidocaine-d10 Hydrochloride 是 Lidocaine Hydrochloride 的氘代化合物。Lidocaine Hydrochloride 的 CAS 号为 73-78-9。Lidocaine hydrochloride 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制MEK/ERK和NF-κB信号通路来减少胃癌细胞的生长,迁移和侵袭。Lidocaine 是一种酰胺衍生物,是一种研究室性心律失常的药物和有效的肿瘤抑制剂。 | |||
T71981 |
Gliclazide-d4
|
||
Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin... |