Ciprostene (calcium salt)

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 μg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 μg/kg/min and 60 ng/ml, respectively.

Phosphorylcholine chloride calcium salt tetrahydrate (Phosphocholine chloride calcium salt tet) 是内源性代谢产物的一种。

Phosphonic acid, [(2R,​3S)​-​3-​methyloxiranyl]​-​, calcium salt (phosphonomycin calcium)是一种抗生素，用于治疗敏感菌株引起的尿路感染和肠道感染。

2-Hydroxy atorvastatin calcium salt 是 Atorvastatin 钙盐的羟基代谢物，Atorvastatin 是一种有效的 HMG-CoA 还原酶抑制剂 (IC50 = 8 nM)。

Moveltipril calcium salt is an ACE inhibitor.

Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate) 是一种还原型叶酸，是一种解毒剂，通常与甲氨蝶呤 (MTX) 联用，以降低 MTX 诱导的毒性。

Fosamprenavir Calcium Salt (GW433908G) 是抗逆转录病毒蛋白酶抑制剂 Amprenavir 的磷酸酯前药，具有改善的溶解性和抗HIV 感染作用。

ortho-Hydroxy Atorvastatin-d5 Calcium Salt 是 ortho-Hydroxy Atorvastatin Calcium Salt 的氘代化合物。ortho-Hydroxy Atorvastatin Calcium Salt 的 CAS 号为 265989-47-7。

para-Hydroxy Atorvastatin-d5 Calcium Salt 是 para-Hydroxy Atorvastatin Calcium Salt 的氘代化合物。para-Hydroxy Atorvastatin Calcium Salt 的 CAS 号为 214217-88-6。

Sacubitril-d4 calcium salt 是 Sacubitril calcium salt 的氘代化合物。

Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. RK-682, a bioactive compound originally isolated from the fermentation of Streptomyces sp. 88-682, is an inhibitor of the PTPs. It inhibits the phosphorylation of CD45 and VHR with IC50 values of 54 and 2 μM, respectively, and arrests cell cycle progress at the G1/S transition. It is also reported to inhibit heparanase (IC50 = 17 μM), an endo-β-D-glucuronidase involved in tumor cell invasion and angiogenesis. RK-682 (calcium salt) is a less soluble version of the free acid.

Bucloxic acid calcium salt 是一种吡唑类衍生物，Bucloxic acid 的钙盐。它是一种抗炎药，具有镇痛和解热作用；也可用于慢性肾小球肾病的研究。

4-hydroxy Atorvastatin is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin.

Atorvastatin-d5 Calcium Salt 是 Atorvastatin Calcium Salt 的氘代化合物。Atorvastatin Calcium Salt 的 CAS 号为 134523-00-5。

Rosuvastatin-d6 Calcium Salt 是 Rosuvastatin Calcium Salt 的氘代化合物。Rosuvastatin Calcium Salt 的 CAS 号为 147098-20-2。Rosuvastatin calcium 是肝羟甲基戊二酰辅酶 A 还原酶的选择性和竞争性抑制剂，具有抗血脂活性。它降低成熟 hERG 的表达以及热休克蛋白 70 与 hERG 蛋白的相互作用，还降低低密度脂蛋白胆固醇、甘油三酯和 C-反应蛋白水平。它阻断人类醚-a-go-go相关基因电流，延迟心脏复极化，来延长动作电位持续时间和校正 QT 间期间隔。

Phosphorylcholine 广泛存在于生物界，是存在于真核生物膜中的磷脂，也存在于与真核生物相关联的共生菌或致病菌中。Phosphorylcholine 具有免疫调节特性，可用于研究动脉粥样硬化。