AChE-IN-8

AChE-IN-8 (Compound 19) is a highly potent inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 value of 1.95 μM. This compound shows promise for further investigation in the research of Alzheimer's disease [1].

AChE BChE-IN-8 (Compound 5a) 是非竞争性AChE 抑制剂和混合型BChE 抑制剂。AChE BChE-IN-8抑制电鳗 AChE (EeAChE) 和马 BChE (eqBChE) 的Ki 值分别为 0.788 μM 和 2.364 μM。AChE BChE-IN-8 具有血脑屏障通透性和低细胞毒性。

Bis-(-)-8-demethylmaritidine，一种天然生物碱，作为乙酰胆碱酯酶（AChE）抑制剂具有有效性。该化合物适用于阿尔茨海默病的研究。

AChE-IN-21 (Compound I-8) is a highly potent and selective orally active inhibitor of acetylcholinesterase (AChE). It exhibits an impressive inhibitory concentration (IC50) of 2.66 nM. Additionally, AChE-IN-21 demonstrates excellent in vitro blood-brain barrier (BBB) permeability [1].