Name: BAY1082439
Brand: TargetMol
SKU: T14511
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 315

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2 mg

¥ 453

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5 mg

¥ 728

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10 mg

¥ 1,230

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25 mg

¥ 1,980

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50 mg

¥ 3,730

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100 mg

¥ 5,380

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产品介绍

生物活性

产品描述	BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2]. Additionally, BAY1082439 is effective against mutated forms of PIK3CA.
体外活性	BAY1082439 is a highly selective PI3Kα/α-balanced inhibitor. BAY1082439 (0.1-1 μM; 72 hours) is more effective than PI3Kα- and/or PI3Kβ-selective inhibitors in blocking PTEN-null prostate cancer cells[2]. BAY1082439 has an IC50 ratio of 1:3 in biochemical assays of PI3Kα (4.9 nM) vs. PI3Kα (15.0 nM), and >1000-fold selectivity against mTOR kinase[1].
体内活性	BAY1082439 (75 mg/kg; p.o.; daily for 4 weeks) is effective in preventing Pten-null prostate cancer progression[2].
别名	N-[8-[[(2R)-2-羟基-3-(吗啉-4-基)丙基]氧基]-7-甲氧基-2,3-二氢咪唑并[1,2-C]喹唑啉-5-基]-2-甲基吡啶-3-甲酰胺

化学信息

分子量	494.54
分子式	C₂₅H₃₀N₆O₅
CAS No.	1375469-38-7
Smiles	COc1c(OC[C@H](O)CN2CCOCC2)ccc2C3=NCCN3C(NC(=O)c3cccnc3C)=Nc12
密度	1.43 g/cm3 (Predicted)

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	DMSO: Slightly soluble

体内实验配液计算器