target/Virus_Protease/3

Rubella virus (strain RA27 3 vaccine) Structural polyprotein (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 53.4 kDa and the accession number is P19725.

Human parainfluenza 3 virus (HPIV-3) (strain Wash 47885 57) Hemagglutinin-neuraminidase Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60.4 kDa and the accession number is P08492-1.

Catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. During viral infection, steroid production contributes to virulence by inhibiting the host inflammatory response. Vaccinia virus (strain Western Reserve) 3-beta-HSD Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 46.9 kDa and the accession number is P26670.

Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA. Hepatitis E virus genotype 3 (HEV-3) Capsid protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.3 kDa and the accession number is Q9YLQ9.

Varicella-zoster virus (VZV) HHV-3 Glycoprotein E gE Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.02 kDa and the accession number is Q9J3M8.

Simian immunodeficiency virus (SIV) (isolate PBj14 BCL-3) Vpx Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 28.9 kDa and the accession number is P19508.

Dengue virus (DENV) (type 3, strain Philippines H87 1956) E Envelope Protein (aa 579-678, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 16.48 kDa and the accession number is AAA99437.1.

HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3 NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. One of the HCV proteases, NS3-4A serine protease, is a non-covalent heterodimer consisting of a catalytic subunit (the N-terminal one-third of NS3 protein) and an activating cofactor (NS4A protein) and is responsible for cleavage at four sites of the HCV polyprotein.

Dengue virus (DENV) (type 3, strain Philippines H87 1956) NS1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.1 kDa and the accession number is AAA99437.1.

Dengue virus (DENV)(type 3, strain Philippines H87 1956) E Envelope Protein (aa 247-675, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.79 kDa and the accession number is AAA99437.1.