ppi

485 种已知活性的 PPI 相关的抑制剂，可用于高通量、高内涵筛选；

ChemDiv的3D模拟PPI库包含1,503种化合物。它包括单一异构体、带保护基的化合物等。 蛋白质间相互作用（PPIs）在许多细胞过程中发挥着核心作用，并参与了多种通路，包括癌症发展的不同阶段、宿主-病原体相互作用以及其他疾病。根据研究发现，在人类体内PPIs的数量约为30万种，与“经典”药物靶点相比，治疗干预的可能性显著增加。尽管长期以来人们普遍认为PPIs难以成为药物靶点，但在过去的10年里，它们作为新的治疗靶点展现出越来越大的潜力。

PPI Pre-Plated Set contains 3743 compounds.

Nature “sees” molecules as 3D surfaces of chemical information. Therefore the biological activity of any given molecule is intrinsically dependent upon its 3D shape Diversity of PPI Library

ChemDiv’s Recognition Elements PPI Library contains 26,000 compounds.

iPPI Tree Library with 1211 compounds was designed with a decision tree algorithm based on several molecular shapes and functional group descriptors.

PPI（蛋白质-蛋白质相互作用）片段库包含3600个化合物。

Modulating protein-protein interactions (PPIs) has been considered an important goal for drug discovery because of their role in numerous cell disorders.

ChemDiv’s Nonpeptide Peptidomimetics PPI library contains 19,400 compounds.

ChemDiv’s Bcl2-PPI Inhibitors Library contains 11,000 compounds.

iPPI Bayesian Library with 2637 compounds was prepared using Bayesian modeling (ECFP6 and FCFP6 fingerprints) based on known active PPI inhibitors (IC50<100 nM) taken from the TIMBAL database.

PPI Focused BBs Library in the Princeton BioMolecal Research contains 400 compounds.

陶术生物针对小规模PPI 药物筛选，基于结构多样性构建PPI 多样性子库，包含10397种小分子化合物。

Nature “sees” molecules as 3D surfaces of chemical information. Therefore the biological activity of any given molecule is intrinsically dependent upon its 3D shape Diversity of PPI Library

ChemDiv’s PDZ PPI Library contains 4,586 compounds.

Formulation of a set of descriptors and ranking mechanisms of arraying fragments based on our thorough analysis of published data enabled us to design the Life Chemicals PPI Fragment Library. It is a collection of 10,900 readily available small-molecule compounds for FBDD that intersect both fragment and PPI inhibitor's chemical spaces.

ASINEX has been working on the design and synthesis of protein-protein interaction (PPI) libraries since 2008. The file contains all available PPI (non-macrocyclic) compounds selected from our Signature & BioDesign Libraries. There are 11439 compounds in the non-macrocyclic PPI Library.

This inspired us to create new subset of our PPI-focused library, namely Helix Turn 3D-mimetics Library. The library has been designed on selected sp3-enriched scaffolds from our DOS chemistry and populated with members that are able to mimic α-helices and β-turns as key recognition elements of protein secondary structure.

ChemDiv’s PPI Tripeptide Mimetics Library contains 25,000 compounds.

There are 3118 compounds in the PPI Library(Macrocyclic).

80 种环肽分子，可用于高通量和高内涵筛选；

210 种活性已知的大环化合物，用于高通量、高内涵筛选；

ChemDiv’s MDM2-p53 Interaction Inhibitors Library contains 22,319 compounds.

ChemDiv’s Anticancer Library contains 65,000 compounds.

蛋白质模拟库包含8960个化合物。

We have designed an MDM2-targeted library of more than 23K small molecule compounds.

蛋白相互作用库包含40640个化合物，旨在发现新型PPI抑制剂。

That allowed us to obtain novel, diverse set of macrocyclic scaffolds and over 3000 stock available molecules, potential PPI modulators.

ChemDiv’s MEF2-HDAC (Class II) Modulators Library contains 6,000 compounds.

ChemDiv’s Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds.