Leflunomide EP Impurity B-d4 是 Leflunomide EP Impurity B 的氘代化合物。Leflunomide EP Impurity B 的 CAS 号为 163451-81-8。Teriflunomide 是一种来氟米特的活性代谢产物,能够抑制嘧啶合成,有效降低T细胞和B细胞增殖,可用于研究类风湿性关节炎。
Laflunimus suppresses immunoglobulin (Ig) secretion, with IC50 values of 2.5 and 2 μM for IgM and IgG, respectively. Laflunimus also is a prostaglandin endoperoxide H synthase (PGHS) -1 and -2 inhibitor. Laflunimus is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726. Laflunimus is an orally active inhibitor of dihydroorotate dehydrogenase (DHODH).
hDHODH-IN-2, an analogue of the active metabolite of Leflunomide, is a human dihydroorotate dehydrogenase (hDHODH) inhibitor with anti-inflammatory activity.