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Targets Recommended: Antibacterial

177

抑制剂 & 化合物

17

天然产物

3

化合物库

30

重组蛋白

7

同位素标记化合物

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Cat. No.	Product Name
L7400	钠通道分子库		118 compounds
	118 种钠通道相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L2800	5-羟色胺分子库		268 compounds
	268 种生物活性小分子化合物，用于高通量、高内涵筛选；
L2610	神经递质受体化合物库		1513 compounds
	1513 种与神经递质受体相关的化合物，用于高通量、高内涵筛选；

化合物库

钠通道分子库

Cat.No: L7400

Compounds: 118

5-羟色胺分子库

Cat.No: L2800

Compounds: 268

神经递质受体化合物库

Cat.No: L2610

Compounds: 1513

Cat. No.	Product Name	Target	Signaling Pathways
T22408	Proflavine 吡啶-3,6-二胺,3,6-Diaminoacridine	Antibacterial	Microbiology/Virology
	Proflavine (3,6-Diaminoacridine) 是吖啶染料，可用作抗菌剂。它是 DNA 嵌入剂，能够阻滞Kir3.2孔。它用作与 Kir3.2 相关的神经系统疾病的研究。
T19723	AMTB hydrochloride AMTB	TRP/TRPV Channel	Membrane transporter/Ion channel
	AMTB hydrochloride (AMTB HCl) 是TRPM8通道的选择性阻滞剂。它抑制 icilin 诱导的 TRPM8 通道激活，pIC50为 6.23。它在膀胱过度活动和膀胱疼痛综合征中有研究的价值。它是电压门控钠通道的非选择性抑制剂 (NaV)。
T0939	Phenytoin 苯妥英,Diphenylhydantoin,5,5-Diphenylhydantoin	Virus Protease; Sodium Channel	Membrane transporter/Ion channel; Microbiology/Virology
	Phenytoin (5,5-Diphenylhydantoin) 是一种有效的电压门控钠离子通道阻滞剂，可减少小鼠乳腺肿瘤的生长和转移，具有抗癫痫活性。
T0438	Proflavine Hemisulfate 3,6-Diaminoacridine hemisulfate,Proflavin hemisulfate,硫酸原黄素	Others; Potassium Channel; DNA; Thrombin; Antibacterial; Autophagy	Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Others; Proteases/Proteasome
	Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) 是一种 DNA 嵌入剂，也是一种吖啶染料。它是抗菌剂，也可作为 Kir3.2孔阻滞剂，可研究与 Kir3.2 相关的神经系统疾病。
T15260	Evenamide NW-3509	Sodium Channel	Membrane transporter/Ion channel
	Evenamide (NW-3509) 是一种口服有效的电压门控钠通道 (sodium channel, VGSC) 阻滞剂，Ki 为 0.4 µM，在精神分裂症中有研究价值。Evenamide 在精神病，躁狂症，抑郁和攻击性的各种啮齿动物模型中具有显著功效。
T2535	Ivabradine hydrochloride 盐酸伊伐布雷定,S 16257-2,Ivabradine HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ivabradine hydrochloride (S 16257-2) 是一种可口服的，超极化激活的环核苷酸门控离子通道通道阻滞剂。
T4497	Amifampridine 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine	Others	Others
	Amifampridine (3,4-Diaminopyridine) 可用于罕见肌肉疾病的研究。
T8333	Aurintricarboxylic acid ATA,NSC-4056,NSC4056,金精三羧酸,NSC 4056	Apoptosis; P2X Receptor; Influenza Virus; Topoisomerase	Apoptosis; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Aurintricarboxylic acid (NSC-4056) 是高效的αβ-亚甲基-ATP 敏感选择性P2X1Rs 和P2X3Rs 变构拮抗剂。它是核糖核酸酶和拓扑异构酶 II 的有效抑制剂，可阻止核酸与酶结合。
T0008	Phenytoin sodium 5,5-Diphenylhydantoin sodium salt,Diphantoine,苯妥英钠,Dilantin sodium,Diphenylhydantoin Sodium	Virus Protease; Sodium Channel	Membrane transporter/Ion channel; Microbiology/Virology
	Phenytoin sodium (Diphantoine) 是一种有效的电压门控钠离子通道阻滞剂，可减少小鼠乳腺肿瘤的生长和转移，具有抗癫痫活性。
T7806	Licarbazepine 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平	Others	Others
	Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) 是一种有效的电压门控钠通道阻滞剂，具有抗惊厥和稳定情绪的功效。
T7516	ZD7288 N-乙基-1,6-二氢-1,2-二甲基-6-(甲基亚氨基)-N-苯基-4-嘧啶胺盐酸盐,ICI D7288	HCN Channel	Membrane transporter/Ion channel
	ZD7288 (ICI D7288) 是一种选择性超极化激活的环核苷酸门控通道阻滞剂，可抑制海马突触可塑性。
T11990	Meclofenamic acid 甲氯芬那酸,Meclofenamate	Others; Gap Junction Protein	Cytoskeletal Signaling; Others
	Meclofenamic acid (Meclofenamate) 是一种非特异性 gap-junction 阻滞剂和特异性脂肪量和肥胖相关 (FTO) 酶抑制剂。 Meclofenamic acid 具有抗炎活性。
T85172	9(Z),11(Z)-Conjugated Linoleic Acid methyl ester 9Z,11Z-CLA	Others	Others
	9(Z),11(Z)-Conjugated Linoleic Acid Methyl Ester serves as a standard in the quantification of conjugated linoleic acid methyl esters via GC-MS, according to Matreya, LLC. Catalog No. 1256.
T37270	9(E),11(E)-12-nitro Conjugated Linoleic Acid	Others	Others
	9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .29(E),11(E)-12-nitro CLA has been found in human plasma. 1.Woodcock, S.R., Salvato...
T74877	GalNAc unconjugated/naked Fitusiran	Others	Others
	GalNAc unconjugated/naked Fitusiran 是一种没有偶联 GalNAc 的小干扰 RNA，专门针对抗凝血酶(AT)信使 RNA，以降低肝脏中 AT 的产生。GalNAc unconjugated/naked Fitusiran 增加凝血酶的生成，并可用于血友病的研究。
T85167	9(Z),11(E)-Conjugated Linoleic Acid methyl ester Methyl 9(Z),11(E)-Octadecadienoate,9Z,11E-CLA	Others	Others
	9(Z),11(E)-Conjugated Linoleic Acid Methyl Ester, identified in lemon grass (C. flexuosus), serves as a standard for quantifying conjugated linoleic acids in thermally stressed olive oil and trans fats in bakery products. [Matreya, LLC. Catalog No. 1255]
T84632	9(E),11(E)-Conjugated Linoleic Acid 9E,11E-CLA	Others	Others
	9(E),11(E)-Conjugated Linoleic Acid (9(E),11(E)-CLA) belongs to a group of eight geometric isomers of linoleic acid, characterized by adjacent double bonds. This specific isomer, 9,11 all-trans linoleic acid, was first discovered in ground beef and is found in various dairy products as well. Notably, it has been shown to decrease mammary tumors in rats with dietary inclusion as minimal as 0.1%. [Matreya, LLC. Catalog No. 1181]
T85026	9(E),11(E)-9-nitro Conjugated Linoleic Acid 9E,11E-9-nitro CLA	Others	Others
	9(E),11(E)-9-nitro Conjugated Linoleic Acid (9E,11E-9-nitro CLA) is a nitrated fatty acid produced from 9Z,11E-CLA through exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or the combined action of myeloperoxidase, hydrogen peroxide, and nitrite. Additionally, it forms in LPS-stimulated RAW 264.7 macrophages, a process that can be inhibited by the nitric oxide synthase (NOS) inhibitor L-NAME. This compound has also been detected in human plasma.
T80249	Epsilon-V1-2, Cys-conjugated	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Epsilon-V1-2, Cys-conjugated 是 εPKC 特异性抑制剂，通过阻断 εPKC 与 εRACK 锚定蛋白之间的相互作用，抑制 εPKC 易位及 MARCKS 磷酸化，从而表现生物活性。该肽将半胱氨酸残基接到 C 末端，以形成与载体蛋白的 SS 键。当序列 N 末端为谷氨酰胺 (Q) 或谷氨酸 (E) 时，肽可自发生成焦谷氨酰 (pGlu)。Q或E到pGlu的转化属于自然过程，并且pGlu的疏水性γ-内酰胺环对提高肽对胃肠道蛋白酶的稳定性起关键作用。在 HPLC 分析中，焦谷氨酰肽作为肽纯度的一部分进行检测，视为这类肽的典型子集。
T85171	9(E),11(E)-Conjugated Linoleic Acid methyl ester Methyl 9(E),11(E)-Octadecadienoate	Others	Others
	9(E),11(E)-Conjugated Linoleic Acid Methyl Ester, identified in thermally stressed cooking oils, can serve as an indicator for the adulteration of olive oils with lower quality oils. [Matreya, LLC. Catalog No. 1257]
T19988	Conjugated Estrogen sodium Conjugated estrogens,Conest,HSDB 3076,Kestrin,Estrogens, conjugated,TAG-39	Others	Others
	Conjugated estrogens are medicine that contains a mixture of estrogen hormones. It is used to treat moderate to severe hot flashes, changes in and around the vagina, and other symptoms of menopause or low amounts of estrogen. Conjugated estrogens tablet i
T35854	9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)	Others	Others
	9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 μM.29(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-inducedGLUT4expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3Dietary administration of 9(Z)11(E)-co...
T74876	GalNAc unconjugated/naked Inclisiran	Others	Others
	GalNAc unconjugated/naked Inclisiran 是一种未偶联GalNAc的双链小干扰RNA (siRNA) 分子，具有抑制PCSK-9转录功能。该化合物主要应用于高脂血症及心血管疾病(CVD)的研究领域。
T21009	Conjugated linoleic acid	Others	Others
	Conjugated linoleic acid, a naturally occurring fatty acid, is present in ruminant meat and dairy products and is produced by a bio-hydrogenation process in the rumen. In this case, the predominant isomer formed is 9cis, 11trans.
T85268	10(E),12(Z)-Conjugated Linoleic Acid methyl ester Methyl 10(E),12(Z)-Octadecadienoate methyl ester,10E,12Z-CLA methyl ester	Others	Others
	10(E),12(Z)-Conjugated linoleic acid methyl ester serves as a standard for quantifying 10(E),12(Z)-conjugated linoleic acid in L. plantarum culture samples. [Matreya, LLC. Catalog No. 1254]
T31716	Etidocaine Hydrochloride W-19053,Duranest,W19053,W 19053	Sodium Channel	Membrane transporter/Ion channel
	Etidocaine Hydrochloride (W19053) 是一种长效麻醉剂和电压门控钠通道阻滞剂。
T77712	Calcium Channel antagonist 3	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Calcium Channel antagonist 3 是一种电压门控钙通道抑制剂（IC50 : 5-20μM）。
T6571	Lomerizine dihydrochloride Terranas,盐酸洛美利嗪,Lomerizine 2HCl,Lomerizine hydrochloride,KB-2796	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Lomerizine dihydrochloride (KB-2796) 是双重 L 和 T 型电压门控钙通道拮抗剂。
T22675	Co 102862 V 102862	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Co 102862 是一种电压门控钠通道阻滞剂。 Co 102862 可用于抗惊厥的研究。
T23497	UK 78282 hydrochloride	Potassium Channel	Membrane transporter/Ion channel
	UK 78282 hydrochloride，一种新型有效且具有选择性的 Kv1.3 阻滞剂。UK 78282 hydrochloride 抑制 Kv1.3 电压门控钾通道，抑制人 T 细胞活化。
T12424	PF-06305591 PF-6305591	Others	Others
	PF-06305591是一种有效的、选择性的电压门钠通道NaV1.8的阻断剂（IC50=15 nM）。
T9751	Transfluthrin	Others	Others
	Transfluthrin 是一种挥发性拟除虫菊酯类杀虫剂，针对昆虫电压门控钠通道 (VGSC)。
T11307	Fluxametamide 4-[5-(3,5-二氯苯基)-4,5-二氢-5-(三氟甲基)-3- 异恶唑基]-N-[(甲氧基氨基)亚甲基]-2-甲基苯甲酰胺	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Fluxametamide 是广谱杀虫剂，是 GABA-和谷氨酸门控氯离子通道拮抗剂，对 M. domestica 中 GABACl 和 GluCl 的IC50值分别为 1.95 和 225  nM。
T11787	Kv3 modulator 1	Others	Others
	Kv3 modulator 1 is a promising compound for the treatment of inflammatory pain. As a modulator of Kv3 voltage-gated potassium channels, Kv3 modulator 1 exhibits potential therapeutic properties in this indication.
T7579	1-BCP Piperonylic acid piperidide	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	1-BCP (Piperonylic acid piperidide) 是一种调节 AMPA 受体门控电流的中枢活性药物，可增强记忆。
T2523	Rufinamide CGP 33101,E 2080,卢非酰胺,RUF 331	Sodium Channel	Membrane transporter/Ion channel
	Rufinamide (E 2080) 是一种新型镇痫化合物，可用于研究 Lennox-Gastaut 综合症。
T77711	Calcium Channel antagonist 4	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Calcium Channel antagonist 4 是一种电压门控钙通道抑制剂（IC50 : 5-20μM）。
T13830	Propoxycaine hydrochloride Propoxycaine HCl	Sodium Channel	Membrane transporter/Ion channel
	Propoxycaine hydrochloride 是一种酯类局部麻醉剂，抑制电压门控的钠通道，可调节神经冲动，可诱导感觉丧失。Propoxycaine hydrochloride 可调节SPMVs脂质双层的流动。
T12181	NaV1.7 inhibitor-1	Sodium Channel	Membrane transporter/Ion channel
	NaV1.7 inhibitor-1 是有效的、选择性的电压门控钠通道 (Nav) 1.7 抑制剂，对于hNaV1.7的IC50为 0.6 nM，其选择性是 hNaV1.5 的 80 倍。
T7899	VU0810464	Potassium Channel	Membrane transporter/Ion channel
	VU0810464 是一种选择性的非尿素蛋白门控的内向整流钾通道激活剂。 VU0810464对神经元 GIRK1/2和GIRK1/4 的EC50分别为165 nM 和720 nM。VU0810464具有脑部渗透性。
T7066	Fosphenytoin disodium Fosphenytoin sodium,ACC-9653,磷苯妥英钠	Sodium Channel	Membrane transporter/Ion channel
	Fosphenytoin disodium (ACC-9653) 是 phenytoin 的前体药物，具有抗惊厥等活性。它是电压门控钠通道阻滞剂。
T6782L	Benzocaine xHCl(94-09-7(free base))	Sodium Channel	Membrane transporter/Ion channel
	Benzocaine xHCl(94-09-7(free base)) 与电压门控 Na+ 通道中的所有其他 rLA 共享一个共同受体（测试的 IC50 为 0.8 mM，电位为 +30 mV）。
T2196	Fipronil 氟虫腈,Fluocyanobenpyrazole,Termidor	P450; GluCls; GABA Receptor	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Fipronil (Fluocyanobenpyrazole) 是昆虫GABA 受体的选择性拮抗剂，可抑制蟑螂神经元中谷氨酸盐引起的脱敏和非脱敏。在分离的大鼠肝微粒体中，它诱导细胞色素 P450 (CYP) 亚型CYP1A1/2、CYP2B1/2和CYP3A1/2的活性。
T12786	RY785	Potassium Channel	Membrane transporter/Ion channel
	RY785 是电压门控钾 (KV2)通道的选择性抑制剂， KV2.2 的 IC50为 0.05 μM。它在缓解疼痛方面具有研究价值。
T0018	Procainamide hydrochloride Procapan,Procainamide HCl,Pronestyl,Procanbid,盐酸普鲁卡因胺	DNA Methyltransferase; Sodium Channel; AChR; Autophagy	Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Neuroscience
	Procainamide hydrochloride (Procapan) 是一种用于研究心律失常的抗心律失常制剂。
T0796	Prilocaine hydrochloride Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因	ATPase; Sodium Channel	Membrane transporter/Ion channel
	Prilocaine hydrochloride (Prilocaine HCl) 是一种氨基酰胺类局部麻醉剂，作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂，具有神经毒性作用。
T15212	Emamectin Benzoate MK-244,甲胺基阿维菌素苯甲酸盐	Apoptosis; Reactive Oxygen Species; GABA Receptor; Parasite	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	Emamectin Benzoate (MK-244) 是口服有效的神经系统毒物，其通过结合昆虫中的 GABA 受体发挥作用。它是阿维菌素的半合成衍生物之一，具有广谱的杀虫和杀螨活性。它诱导ROS 介导的 DNA 损伤和细胞凋亡。
T22361	Mepivacaine Carbocaine	Sodium Channel	Membrane transporter/Ion channel
	Mepivacaine (Carbocaine) 是一种可用于局部麻醉的酰胺类化合物，可使人或动物短暂的失去自知觉。Mepivacaine 通过与神经细胞膜上特定的电压门控钠离子通道结合，抑制钠离子内流和膜去极化来发挥作用。Mepivacaine 适用于神经阻滞和硬膜外麻醉。
T8639	Phenibut (hydrochloride) 3-Amino-4-phenylbutyric acid hydrochloride,3-氨基-4-苯基丁酸盐酸盐	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Phenibut hydrochloride (3-Amino-4-phenylbutyric acid hydrochloride) 是 GABA-B 激动剂，口服有活性，可作用于 GABAB 受体，充当 GABA 类似物。它具有促智 (增强认知) 及抗焦虑的能力。
T4298	JNJ-47965567 JNJ-479655	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	JNJ-47965567 (JNJ-479655) 是中枢通透性、高亲和力、选择性的P2X7拮抗剂，可用于探讨中枢 P2X7 在中枢神经系统病理生理模型中的作用。它对人和大鼠 P2X7 作用的pKi 值分别为 7.9 和 8.7。

化合物

Cat.No: T22408

Synonym: 吡啶-3,6-二胺,3,6-Diaminoacridine

Target: Antibacterial

AMTB hydrochloride

Cat.No: T19723

Synonym: AMTB

Target: TRP/TRPV Channel

Cat.No: T0939

Synonym: 苯妥英,Diphenylhydantoin,5,5-Diphenylhydantoin

Target: Virus Protease, Sodium Channel

Proflavine Hemisulfate

Cat.No: T0438

Synonym: 3,6-Diaminoacridine hemisulfate,Proflavin hemisulfate,硫酸原黄素

Target: Others, Potassium Channel, DNA, Thrombin, Antibacterial, Autophagy

Cat.No: T15260

Synonym: NW-3509

Target: Sodium Channel

Ivabradine hydrochloride

Cat.No: T2535

Synonym: 盐酸伊伐布雷定,S 16257-2,Ivabradine HCl

Target: Adrenergic Receptor

Cat.No: T4497

Synonym: 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine

Target: Others

Aurintricarboxylic acid

Cat.No: T8333

Synonym: ATA,NSC-4056,NSC4056,金精三羧酸,NSC 4056

Target: Apoptosis, P2X Receptor, Influenza Virus, Topoisomerase

Phenytoin sodium

Cat.No: T0008

Synonym: 5,5-Diphenylhydantoin sodium salt,Diphantoine,苯妥英钠,Dilantin sodium,Diphenylhydantoin Sodium

Target: Virus Protease, Sodium Channel

Cat.No: T7806

Synonym: 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平

Target: Others

Cat.No: T7516

Synonym: N-乙基-1,6-二氢-1,2-二甲基-6-(甲基亚氨基)-N-苯基-4-嘧啶胺盐酸盐,ICI D7288

Target: HCN Channel

Meclofenamic acid

Cat.No: T11990

Synonym: 甲氯芬那酸,Meclofenamate

Target: Others, Gap Junction Protein

9(Z),11(Z)-Conjugated Linoleic Acid methyl ester

Cat.No: T85172

Synonym: 9Z,11Z-CLA

Target: Others

9(E),11(E)-12-nitro Conjugated Linoleic Acid

Cat.No: T37270

Target: Others

GalNAc unconjugated/naked Fitusiran

Cat.No: T74877

Target: Others

9(Z),11(E)-Conjugated Linoleic Acid methyl ester

Cat.No: T85167

Synonym: Methyl 9(Z),11(E)-Octadecadienoate,9Z,11E-CLA

Target: Others

9(E),11(E)-Conjugated Linoleic Acid

Cat.No: T84632

Synonym: 9E,11E-CLA

Target: Others

9(E),11(E)-9-nitro Conjugated Linoleic Acid

Cat.No: T85026

Synonym: 9E,11E-9-nitro CLA

Target: Others

Epsilon-V1-2, Cys-conjugated

Cat.No: T80249

Target: PKC

9(E),11(E)-Conjugated Linoleic Acid methyl ester

Cat.No: T85171

Synonym: Methyl 9(E),11(E)-Octadecadienoate

Target: Others

Conjugated Estrogen sodium

Cat.No: T19988

Synonym: Conjugated estrogens,Conest,HSDB 3076,Kestrin,Estrogens, conjugated,TAG-39

Target: Others

9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)

Cat.No: T35854

Target: Others

GalNAc unconjugated/naked Inclisiran

Cat.No: T74876

Target: Others

Conjugated linoleic acid

Cat.No: T21009

Target: Others

10(E),12(Z)-Conjugated Linoleic Acid methyl ester

Cat.No: T85268

Synonym: Methyl 10(E),12(Z)-Octadecadienoate methyl ester,10E,12Z-CLA methyl ester

Target: Others

Etidocaine Hydrochloride

Cat.No: T31716

Synonym: W-19053,Duranest,W19053,W 19053

Target: Sodium Channel

Calcium Channel antagonist 3

Cat.No: T77712

Target: Calcium Channel

Lomerizine dihydrochloride

Cat.No: T6571

Synonym: Terranas,盐酸洛美利嗪,Lomerizine 2HCl,Lomerizine hydrochloride,KB-2796

Target: Calcium Channel

Cat.No: T22675

Synonym: V 102862

Target: Others, Sodium Channel

UK 78282 hydrochloride

Cat.No: T23497

Target: Potassium Channel

Cat.No: T12424

Synonym: PF-6305591

Target: Others

Cat.No: T9751

Target: Others

Cat.No: T11307

Synonym: 4-[5-(3,5-二氯苯基)-4,5-二氢-5-(三氟甲基)-3- 异恶唑基]-N-[(甲氧基氨基)亚甲基]-2-甲基苯甲酰胺

Target: GABA Receptor

Kv3 modulator 1

Cat.No: T11787

Target: Others

Cat.No: T7579

Synonym: Piperonylic acid piperidide

Target: GluR, iGluR

Cat.No: T2523

Synonym: CGP 33101,E 2080,卢非酰胺,RUF 331

Target: Sodium Channel

Calcium Channel antagonist 4

Cat.No: T77711

Target: Calcium Channel

Propoxycaine hydrochloride

Cat.No: T13830

Synonym: Propoxycaine HCl

Target: Sodium Channel

NaV1.7 inhibitor-1

Cat.No: T12181

Target: Sodium Channel

Cat.No: T7899

Target: Potassium Channel

Fosphenytoin disodium

Cat.No: T7066

Synonym: Fosphenytoin sodium,ACC-9653,磷苯妥英钠

Target: Sodium Channel

Benzocaine xHCl(94-09-7(free base))

Cat.No: T6782L

Target: Sodium Channel

Cat.No: T2196

Synonym: 氟虫腈,Fluocyanobenpyrazole,Termidor

Target: P450, GluCls, GABA Receptor

Cat.No: T12786

Target: Potassium Channel

Procainamide hydrochloride

Cat.No: T0018

Synonym: Procapan,Procainamide HCl,Pronestyl,Procanbid,盐酸普鲁卡因胺

Target: DNA Methyltransferase, Sodium Channel, AChR, Autophagy

Prilocaine hydrochloride

Cat.No: T0796

Synonym: Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因

Target: ATPase, Sodium Channel

Emamectin Benzoate

Cat.No: T15212

Synonym: MK-244,甲胺基阿维菌素苯甲酸盐

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, Parasite

Cat.No: T22361

Synonym: Carbocaine

Target: Sodium Channel

Phenibut (hydrochloride)

Cat.No: T8639

Synonym: 3-Amino-4-phenylbutyric acid hydrochloride,3-氨基-4-苯基丁酸盐酸盐

Target: GABA Receptor

Cat.No: T4298

Synonym: JNJ-479655

Target: P2X Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T2173	Veratridine	Sodium Channel	Membrane transporter/Ion channel
	Veratridine 是一种生物碱，来自百合科植物。Veratridine 是一种钠通道激动剂，对 Nav1.7 的峰值电流具有抑制作用，IC50为 18.39 µM。
T3013	Catharanthine tartrate Catharanthine hemitartrate,酒石酸长春质碱	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Catharanthine tartrate (Catharanthine hemitartrate) 是长春花中的一种生物碱，可抑制电压门控 L 型钙离子通道，具有抗肿瘤和降血压活性。
TQ0192	Senecionine Aureine,Senecionan-11,16-dione, 12-hydroxy-,千里光宁,Senecionin	Others	Others
	Senecionine 是一种吡咯里西啶生物碱，从Senecio vulgaris中分离得到，它对动物和人类有毒性。
T4S1869	12-Epinapelline 12-表欧乌头碱,12-表-欧乌头碱	Others	Others
	12-Epinapelline 是一种二萜生物碱，分离自Aconitum baikalense 中。它具有抗炎作用，能刺激成纤维细胞前体克隆的生长。
T3021	Bulleyaconitine A 草乌甲素,Bulleyaconi cine A	Sodium Channel	Membrane transporter/Ion channel
	Bulleyaconitine A (Bulleyaconi cine A) 是一种分离自乌头属植物的抗炎活性化合物，也可用于缓解疼痛的研究。
T5288	Cytidine-5'-triphosphate disodium 胞苷 5'-三磷酸二钠盐,CTP,Cytidine 5'-triphosphate (disodium salt)	Others; Endogenous Metabolite	Metabolism; Others
	Cytidine 5'-triphosphate disodium salt 是内源性代谢产物的一种，是一种阳离子渗透性配体门控离子通道激动剂。
T1131	Ivermectin MK-933,伊维菌素	Mitophagy; GluCls; P2X Receptor; SARS-CoV; HIV Protease; Antibiotic; Parasite; Autophagy; HSV	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ivermectin (MK-933) 是谷氨酸门控氯离子通道激活剂，具有抗寄生虫活性。它特异性抑制Impα/β1 介导的核导入，还抑制牛疱疹病毒 1 复制并抑制BoHV-1DNA 聚合酶的核输入。它具有很强的抗病毒活性。它也是P2X4和 α7nAChRs 的正异构效应物。
TN6713	6-Benzoylheteratisine Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth,苯甲酰新异乌头碱	Sodium Channel	Membrane transporter/Ion channel
	6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) 是乌头碱的拮抗剂，乌头碱是天然 Na+通道激活剂。
TN2347	Methylsticin 麻醉椒苦素,Methysticin	Others	Others
	Methylsticin (Methysticin) 是一种卡瓦内酯，从卡瓦根中分离得到。它能够抑制破骨细胞形成的活性。
T8716	physalin F 酸浆苦味素F,酸浆苦素 F	Apoptosis	Apoptosis
	Physalin F 是一种分泌型甾体，诱导人外周血单个核细胞凋亡，降低人 T 淋巴细胞 1 型病毒感染后的自发增殖和细胞因子的产生，具有强烈抗炎和免疫调节作用。
T4S0537	Neoline Bullatine B,雪上一枝蒿乙素	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Neoline 是一种乌头根 (PA) 的活性成分，可改善奥沙利铂引起的小鼠周围神经病变。Neoline 通对Nav1.7 电压门控钠通道电流 (VGSC)有抑制作用。它可用作标记化合物，从而测定用于研究神经性疼痛的 PA 产品的质量。
TN2322	Yangambin	Calcium Channel; PAFR	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素，是选择性PAF 受体拮抗剂，通过调控Ca2+通道抑制 Ca2+流入，导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少，具有降压作用。
TN1254	3'-Methoxydaidzein 3'-甲氧基大豆苷元	Sodium Channel	Membrane transporter/Ion channel
	3'-Methoxydaidzein 是一种异黄酮和 Sodium Channel 双重抑制剂。3'-Methoxydaidzein 对NaV1.7、NaV1.8 和 NaV1.3有抑制作用，IC50 分别为 181 nM、397 nM 和 505 nM。 3'-Methoxydaidzein 对胶原诱导的血小板聚集具有特异性，IC50值分别为12.3和61.5µM。。3'-Methoxydaidzein 通过抑制电压门控钠通道发挥镇痛作用。 3'-Methoxydaidzein 具有抗氧化活性和抗血小板聚集活性。
T10609	Brevetoxin-3 PbTx-3	Others	Others
	Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator. Brevetoxin-3 has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels.
TN7268	Milbemycin A4 Antibiotic B 41A4,Milbemycin α3	Others	Others
	Milbemycin A4, a distinguished member of the macrocyclic lactones family featuring a unique spiroketal group, is derived from the fermentation of the soil bacterium Streptomyces hygroscopicus subsp. aureolacrimosus. It acts by enhancing the opening of glutamate and GABA-gated chloride channels, rendering it effective as both a nematocide and insecticide.
T27564	Hymenidin	5-HT Receptor	GPCR/G Protein; Neuroscience
	Hymenidin是一种从冲绳海绵Hymeniacidon sp。中分离出的生物碱，是一种5-羟色胺能受体拮抗剂和电压门控钾通道抑制剂，具有潜在的抗原生动物作用，可选择性结合 FOXO1 DNA ，可降低去极化诱导的细胞钙升高。
T36068	Brevetoxin B	Others	Others
	Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

天然产物

Cat.No: T2173

Target: Sodium Channel

Catharanthine tartrate

Cat.No: T3013

Synonym: Catharanthine hemitartrate,酒石酸长春质碱

Target: Others, Calcium Channel

Cat.No: TQ0192

Synonym: Aureine,Senecionan-11,16-dione, 12-hydroxy-,千里光宁,Senecionin

Target: Others

12-Epinapelline

Cat.No: T4S1869

Synonym: 12-表欧乌头碱,12-表-欧乌头碱

Target: Others

Bulleyaconitine A

Cat.No: T3021

Synonym: 草乌甲素,Bulleyaconi cine A

Target: Sodium Channel

Cytidine-5'-triphosphate disodium

Cat.No: T5288

Synonym: 胞苷 5'-三磷酸二钠盐,CTP,Cytidine 5'-triphosphate (disodium salt)

Target: Others, Endogenous Metabolite

Cat.No: T1131

Synonym: MK-933,伊维菌素

Target: Mitophagy, GluCls, P2X Receptor, SARS-CoV, HIV Protease, Antibiotic, Parasite, Autophagy, HSV

6-Benzoylheteratisine

Cat.No: TN6713

Synonym: Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth,苯甲酰新异乌头碱

Target: Sodium Channel

Cat.No: TN2347

Synonym: 麻醉椒苦素,Methysticin

Target: Others

Cat.No: T8716

Synonym: 酸浆苦味素F,酸浆苦素 F

Target: Apoptosis

Cat.No: T4S0537

Synonym: Bullatine B,雪上一枝蒿乙素

Target: Others, Sodium Channel

Cat.No: TN2322

Target: Calcium Channel, PAFR

3'-Methoxydaidzein

Cat.No: TN1254

Synonym: 3'-甲氧基大豆苷元

Target: Sodium Channel

Cat.No: T10609

Synonym: PbTx-3

Target: Others

Cat.No: TN7268

Synonym: Antibiotic B 41A4,Milbemycin α3

Target: Others

Cat.No: T27564

Target: 5-HT Receptor

Cat.No: T36068

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01890	KCNA1 Protein, Human, Recombinant (His) Voltage-gated potassium channel subunit Kv1.1,Volta...	Human	E. coli
	KCNA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 22.2 kDa and the accession number is Q09470.
TMPY-03183	SCN2B Protein, Human, Recombinant (hFc) sodium channel, voltage gated, type II beta subunit...	Human	HEK293 Cells
	SCN2B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.2 kDa and the accession number is O60939.
TMPH-03603	KcsA Protein, S. coelicolor, Recombinant (His) pH-gated potassium channel KcsA,kcsA	Streptomyces coelicolor	E. coli
	Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel. KcsA Protein, S. coelicolor, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 23.7 kDa and the accession number is P0A333.
TMPY-03697	SCN2B Protein, Human, Recombinant (His) ATFB14,sodium channel, voltage gated, type II beta ...	Human	HEK293 Cells
	SCN2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.7 kDa and the accession number is O60939.
TMPY-02976	SCN3B Protein, Human, Recombinant (His) ATFB16,HSA243396,BRGDA7,SCNB3,sodium channel, voltage ga...	Human	HEK293 Cells
	SCN3B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.2 kDa and the accession number is Q9NY72.
TMPY-02722	SCN3B Protein, Human, Recombinant (hFc) ATFB16,HSA243396,sodium channel, voltage gated, typ...	Human	HEK293 Cells
	SCN3B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.5 kDa and the accession number is Q9NY72.
TMPH-02309	KCNAB2 Protein, Human, Recombinant (His & SUMO) Kv-beta-2,K(+) channel subunit beta-2,KCNAB2,Voltage-gat...	Human	E. coli
	KCNAB2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 57.0 kDa and the accession number is Q13303.
TMPH-02308	CACNA2D1 Protein, Human, Recombinant (His & SUMO) MHS3,Voltage-dependent calcium channel subunit alpha-2/delta...	Human	E. coli
	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
TMPH-01891	KCNE2 Protein, Human, Recombinant (His) MinK-related peptide 1,Potassium voltage-gated chan...	Human	E. coli
	KCNE2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 17.3 kDa and the accession number is Q9Y6J6.
TMPH-02118	SCN1A Protein, Human, Recombinant (His) Sodium channel protein brain I subunit alpha,Sodium channel ...	Human	E. coli
	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neur...
TMPH-00780	CACNA1C Protein, Guinea Pig, Recombinant (His) CACNA1C,CACNL1A1,CACH2,CACN2,Voltage-dependent L-type calciu...	Guinea pig	E. coli
	Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressur...
TMPY-05558	Recombinant Protein L, PE conjugated		E. coli
	Recombinant Protein L, PE conjugated is expressed in E. coli expression system.
TMPY-05573	CD38 Protein, Human, Recombinant (His), PE conjugated T10,ADPRC1,ADPRC 1,CD38 molecule	Human	HEK293 Cells
	CD38 Protein, Human, Recombinant (His), PE conjugated is expressed in HEK293 mammalian cells with His tag. The accession number is NP_001766.2.
TMPY-05568	BCMA/TNFRSF17 Protein, Human (His & hFc), PE conjugated BCMA,TNFRSF13A,tumor necrosis factor receptor superfamily me...	Human	HEK293 Cells
	BCMA/TNFRSF17 Protein, Human (His & hFc), PE conjugated is expressed in HEK293 mammalian cells with His and Fc tag. The accession number is NP_001183.2.
TMPY-05574	CD38 Protein, Human, Recombinant (His), FITC conjugated CD38 molecule,T10,ADPRC 1,ADPRC1	Human	HEK293 Cells
	CD38 Protein, Human, Recombinant (His), FITC conjugated is expressed in HEK293 mammalian cells with His tag. The accession number is NP_001766.2.
TMPY-05567	BCMA/TNFRSF17 Protein, Human (His & hFc), FITC conjugated tumor necrosis factor receptor superfamily member 17,BCMA,TN...	Human	HEK293 Cells
	BCMA/TNFRSF17 Protein, Human (His & hFc), FITC conjugated is expressed in HEK293 mammalian cells with His and Fc tag. The accession number is NP_001183.2.
TMPY-05572	Siglec-3/CD33 Protein, Human, Recombinant, PE conjugated Siglec-3,p67,CD33 molecule,SIGLEC3	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant, PE conjugated is expressed in HEK293 mammalian cells. The accession number is AAH28152.1.
TMPY-05571	Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated CD33 molecule,Siglec-3,p67,SIGLEC3	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated is expressed in HEK293 mammalian cells. The accession number is AAH28152.1.
TMPY-02245	SNAP-25 Protein, Human, Recombinant (His) synaptosomal-associated protein, 25kDa,SEC9,SNAP,RIC-4,dJ106...	Human	E. coli
	Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the sp...
TMPH-03751	CYBB Protein, Human, Recombinant (His) NADPH oxidase 2,Heme-binding membrane glycoprotein gp91phox,...	Human	E. coli
	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
TMPY-03615	CSEN Protein, Human, Recombinant (His) Kv channel interacting protein 3, calsenilin,DREAM,KCHIP3,CS...	Human	E. coli
	KCNIP3 (Potassium Voltage-Gated Channel Interacting Protein 3, also known as CSEN) is a Protein Coding gene. CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. CSEN also functions as a calc...
TMPH-01394	GRIN1 Protein, Human, Recombinant (His) N-methyl-D-aspartate receptor subunit NR1,Glutamate [NMDA] r...	Human	E. coli
	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. GRIN1 Protein, Human, Recombinant (His)...
TMPH-01609	LGI1 Protein, Human, Recombinant (His & Myc) Leucine-rich glioma-inactivated protein 1,Epitempin-1,LGI1	Human	E. coli
	Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.
TMPH-01744	NOX1 Protein, Human, Recombinant (His) NADH/NADPH mitogenic oxidase subunit P65-MOX,NADPH oxidase 1...	Human	E. coli
	NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis t...
TMPH-02331	GLRA1 Protein, Human, Recombinant (His & Myc) Glycine receptor subunit alpha-1,GLRA1,Glycine receptor stry...	Human	E. coli
	Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiat...
TMPJ-00587	NRCAM Protein, Human, Recombinant (hFc) gCAM-related cell adhesion molecule,hBravo,Ng-CAM-related,Nr...	Human	HEK293 Cells
	Neuronal cell adhesion molecule(NRCAM) is a single-pass type I membrane protein ,containing 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. NrCAM is engaged in such biological processes as axonal fasciculation, cell-cell adhesion, central nervous system development, clustering of voltage-gated sodium channels, neuron migration, positive regulation of neuron differentiation, regulation of axon extension, and synaptog...
TMPH-00056	Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His) ATX II,Delta-AITX-Avd1c,Toxin II,Delta-actitoxin-Avd1c,Neuro...	Anemonia sulcata	P. pastoris (Yeast)
	Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured...
TMPY-04318	GRIK2 Protein, Human, Recombinant (hFc) GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate...	Human	HEK293 Cells
	GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl...
TMPY-01854	DPP10 Protein, Human, Recombinant (His) DPPY,DPRP3,DPRP-3,DPL2,dipeptidyl-peptidase 10 (non-function...	Human	HEK293 Cells
	Inactive dipeptidyl peptidase 1, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP1, is a single-pass type II membrane protein which belongs to thepeptidase S9B family.DPPIV subfamily. It may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. DPP1 / DPRP3 has no detectable protease activity, most likely due to the absence of the conserved serine residue normally p...
TMPY-01692	NETO1 Protein, Human, Recombinant (His) neuropilin (NRP) and tolloid (TLL)-like 1,BCTL1,BTCL1	Human	HEK293 Cells
	Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus repr...

重组蛋白

KCNA1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01890

Species: Human

Expression System: E. coli

SCN2B Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03183

Species: Human

Expression System: HEK293 Cells

KcsA Protein, S. coelicolor, Recombinant (His)

Cat.No: TMPH-03603

Species: Streptomyces coelicolor

Expression System: E. coli

SCN2B Protein, Human, Recombinant (His)

Cat.No: TMPY-03697

Species: Human

Expression System: HEK293 Cells

SCN3B Protein, Human, Recombinant (His)

Cat.No: TMPY-02976

Species: Human

Expression System: HEK293 Cells

SCN3B Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02722

Species: Human

Expression System: HEK293 Cells

KCNAB2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02309

Species: Human

Expression System: E. coli

CACNA2D1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02308

Species: Human

Expression System: E. coli

KCNE2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01891

Species: Human

Expression System: E. coli

SCN1A Protein, Human, Recombinant (His)

Cat.No: TMPH-02118

Species: Human

Expression System: E. coli

CACNA1C Protein, Guinea Pig, Recombinant (His)

Cat.No: TMPH-00780

Species: Guinea pig

Expression System: E. coli

Recombinant Protein L, PE conjugated

Cat.No: TMPY-05558

Expression System: E. coli

CD38 Protein, Human, Recombinant (His), PE conjugated

Cat.No: TMPY-05573

Species: Human

Expression System: HEK293 Cells

BCMA/TNFRSF17 Protein, Human (His & hFc), PE conjugated

Cat.No: TMPY-05568

Species: Human

Expression System: HEK293 Cells

CD38 Protein, Human, Recombinant (His), FITC conjugated

Cat.No: TMPY-05574

Species: Human

Expression System: HEK293 Cells

BCMA/TNFRSF17 Protein, Human (His & hFc), FITC conjugated

Cat.No: TMPY-05567

Species: Human

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant, PE conjugated

Cat.No: TMPY-05572

Species: Human

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated

Cat.No: TMPY-05571

Species: Human

Expression System: HEK293 Cells

SNAP-25 Protein, Human, Recombinant (His)

Cat.No: TMPY-02245

Species: Human

Expression System: E. coli

CYBB Protein, Human, Recombinant (His)

Cat.No: TMPH-03751

Species: Human

Expression System: E. coli

CSEN Protein, Human, Recombinant (His)

Cat.No: TMPY-03615

Species: Human

Expression System: E. coli

GRIN1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01394

Species: Human

Expression System: E. coli

LGI1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01609

Species: Human

Expression System: E. coli

NOX1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01744

Species: Human

Expression System: E. coli

GLRA1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02331

Species: Human

Expression System: E. coli

NRCAM Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00587

Species: Human

Expression System: HEK293 Cells

Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His)

Cat.No: TMPH-00056

Species: Anemonia sulcata

Expression System: P. pastoris (Yeast)

GRIK2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04318

Species: Human

Expression System: HEK293 Cells

DPP10 Protein, Human, Recombinant (His)

Cat.No: TMPY-01854

Species: Human

Expression System: HEK293 Cells

NETO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01692

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T12023	Mexiletine-d6 hydrochloride KOE-1173 D6 hydrochloride,Mexiletine D6 hydrochloride	Others	Others
	Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic.
TMID-0295	Fosphenytoin Sodium-d10
	Fosphenytoin Sodium-d10 是 Fosphenytoin Sodium 的氘代化合物。Fosphenytoin Sodium 的 CAS 号为 92134-98-0。Fosphenytoin sodium 是 phenytoin 的前体药物，具有抗惊厥等活性。它是电压门控钠通道阻滞剂。
T37608	Riluzole-13C,15N2 Riluzole-13C,15N2
	Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals a...
T68918	Phenytoin-d10
	Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal...
TMID-0070	Amiodarone-d10 Hydrochloride
	Amiodarone-d10 Hydrochloride 是 Amiodarone Hydrochloride 的氘代化合物。Amiodarone Hydrochloride 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物，通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间，可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化，可研究室上性和室性心律失常。
TMID-0069	Amiodarone-d4 HCl
	Amiodarone-d4 HCl 是 Amiodarone HCl 的氘代化合物。Amiodarone HCl 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物，通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间，可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化，可研究室上性和室性心律失常。
TMID-0299	Zonisamide-d4
	Zonisamide-d4 是 Zonisamide 的氘代化合物。Zonisamide 的 CAS 号为 68291-97-4。Zonisamide 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂，对人类线粒体同工酶 hCA II 和 hCA V 作用的Ki值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性，在癫痫、癫痫发作和帕金森病的研究中具有价值。

同位素标记化合物

Mexiletine-d6 hydrochloride

Cat.No: T12023

Synonym: KOE-1173 D6 hydrochloride,Mexiletine D6 hydrochloride

Target: Others

Fosphenytoin Sodium-d10

Cat.No: TMID-0295

Riluzole-13C,15N2

Cat.No: T37608

Synonym: Riluzole-13C,15N2

Cat.No: T68918

Amiodarone-d10 Hydrochloride

Cat.No: TMID-0070

Amiodarone-d4 HCl

Cat.No: TMID-0069

Cat.No: TMID-0299

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