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Search Results for " cell proliferation inhibition "

Targets Recommended: FLT

101

抑制剂 & 化合物

18

天然产物

1

化合物库

1

TargetMol 试剂盒

22

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name
L5300	线粒体靶向库		812 compounds
	812 种具有潜在或确定线粒体靶向活性的化合物，以促进针对线粒体的药物研究；

化合物库

线粒体靶向库

Cat.No: L5300

Compounds: 812

Cat. No.	Product Name	Form	Specificity Of Inhibition
C0048	Deacetylase Inhibitor Cocktail (100× in 70% DMSO) 去乙酰化酶抑制剂 Cocktail（100× in 70% DMSO）	Solution (100× in 70% DMSO)

TargetMol 试剂盒

去乙酰化酶抑制剂 Cocktail（100× in 70% DMSO）

Cat.No: C0048

Cat. No.	Product Name	Target	Signaling Pathways
T2051	SKLB4771 FLT3-IN-1,FLT3-IN-1	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	SKLB4771 (FLT3-IN-1) 是一种新型的、高效的 Flt3 抑制剂 (IC50:10nM)。
T4235	Roblitinib FGF-401	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Roblitinib (FGF-401) 是一种口服有效的，高选择性的FGFR4抑制剂(IC50:1.9 nM)，具有抗癌作用。
T6831	Etretinate Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359,依曲替酯	Apoptosis; Others	Apoptosis; Others
	Etretinate (Ro 10-9359) 是一种口服芳香族维甲酸，对牛皮癣和其他皮肤病综合征有效。它激活类视黄醇受体，引起细胞分化的诱导、细胞增殖的抑制和炎症细胞对组织浸润的抑制。
T3352	XL413	cholecystokinin; Casein Kinase; Pim; CDK	Cell Cycle/Checkpoint; Chromatin/Epigenetic; GPCR/G Protein; JAK/STAT signaling; Metabolism; Stem Cells
	XL413 是一种口服生物可利用的细胞分裂周期 7 同源物 (CDC7) 激酶抑制剂，具有潜在的抗肿瘤活性，IC50值为 3.4 nM。它对 pMCM 的 EC50值为 118 nM，对 CK2 和 PIM1 的 IC50值分别为 215 和 42 nM。
T6017	Linsitinib OSI-906,林西替尼	IGF-1R	Tyrosine Kinase/Adaptors
	Linsitinib (OSI-906) 是选择性的、有效的、具有口服活性的IGF-1和胰岛素受体(IR)的双重抑制剂，IC50分别为 35 和 75 nM。
T3623	Cobimetinib 可美替尼,考比替尼,RG7420,XL518,GDC-0973	Apoptosis; MEK	Apoptosis; MAPK
	Cobimetinib (GDC-0973) 是一种可口服的 MEK1选择性抑制剂，抑制MEK1的IC50为4.2 nM。
T1849	Momelotinib CYT11387,CYT387,LM-1149	Apoptosis; JAK; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Momelotinib (LM-1149) 是一种 ATP 竞争性的 JAK1/JAK2抑制剂，IC50值分别为 11 nM/18 nM。
T2307	Icotinib Hydrochloride 埃克替尼盐酸盐,盐酸埃克替尼,BPI-2009H	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Icotinib Hydrochloride (BPI-2009H) 是一种口服的基于喹唑啉的表皮生长因子受体 (EGFR) 抑制剂，IC50值为5 nM，具有潜在的抗肿瘤活性。
T12831L	SAR405	PI3K; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	SAR-405 是一种选择性 PIK3C3/Vps34 抑制剂，IC50为1.2 nM，Kd 为1.5 nM，可防止自噬并与肿瘤细胞中的 MTOR 抑制协同作用。它抑制饥饿或 mTOR 抑制诱导的自噬，具有抗癌活性。
T6334	Ridaforolimus AP23573,Deforolimus,MK-8669	mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物，具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂，在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。
T1574	Etoricoxib Arcoxia,MK-663,Tauxib,L-791456,Nucoxia,Desvenlafaxine,依托考昔	COX	Immunology/Inflammation; Neuroscience
	Etoricoxib (MK-663) 是一种合成的非甾体抗炎药 (NSAID)，具有解热、镇痛和潜在的抗肿瘤特性。它是可口服的选择性 COX-2抑制剂，对人全血 COX-2 和 COX-1 的 IC50值分别为 1.1 和 116 μM。
T3211	Midostaurin 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂，有抗肿瘤活性，对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。
T68405	KW-2450 free base	IGF-1R	Tyrosine Kinase/Adaptors
	KW-2450 free base 是一种 IGF-1R/IR和酪氨酸激酶多重抑制剂具有抗肿瘤活性。KW-2450 free base 在小鼠 HT-29/GFP 结肠癌异种移植模型中显示出适度的生长抑制活性并抑制 IGF-1 诱导的信号转导。
T11096	DRI-C21045	NF-κB	NF-κB
	DRI-C21045 是一种有效的 CD40-CD40L 协同刺激蛋白-蛋白质相互作用的选择性抑制剂，IC50 为 0.17 μM。它显示对 CD40L 诱导的 NF-κB 活化和 B 细胞增殖的浓度依赖性抑制，IC50分别为 17.1 μM 和 4.5 μM。
T50107	Neuroprotective agent 1	Others	Others
	ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate 是一种合成化合物，属于姜黄素家族。它通过抑制NF-κB 信号通路参与免疫反应和炎症的调节，通过激活Nrf2信号通路参与抗氧化反应的调节，通过抑制Akt 信号通路参与细胞存活和增殖的调节。
T70008	Bomedemstat ditosylate MK-3543 ditosylate,IMG-7289 ditosylate	Apoptosis; Histone Demethylase	Apoptosis; Chromatin/Epigenetic
	Bomedemstat ditosylate (IMG-7289 ditosylate) 是一种具有口服活性的 lysine-specific demethylase 1 (LSD1) 抑制剂，具有抗肿瘤活性，增强 SCLC 同基因模型中对 PD-1 抑制的反应，抑制癌细胞增殖，诱导细胞凋亡。Bomedemstat ditosylate 可用于研究骨髓增生性肿瘤和骨髓纤维化。
T1185	Rofecoxib MK 966,罗非昔布,罗非考昔,MK-0966	COX	Immunology/Inflammation; Neuroscience
	Rofecoxib (MK 966) 是可口服的 COX-2特异性抑制剂，具有抗炎、解热和镇痛特性以及潜在的抗肿瘤特性。在人骨肉瘤细胞和中国仓鼠卵巢细胞中，对人 COX-2 的 IC50值分别为 26 和 18 nM。
T3626	Acalabrutinib ACP-196,阿可替尼	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Acalabrutinib (ACP-196) 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK 抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。
T14884	CBR-5884	Others; Dehydrogenase	Metabolism; Others
	CBR-5884 是一种磷酸甘油酸脱氢酶抑制剂，IC50为 33 μM。它抑制癌细胞中的丝氨酸合成，选择性地抑制黑素瘤和乳腺癌细胞系的增殖，对具有高丝氨酸生物合成活性的癌细胞系有选择性毒性。
T3630	Relugolix RVT-601,瑞卢戈利,TAK-385	GNRH Receptor	GPCR/G Protein
	Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。
T12009	Telomerase-IN-1	Telomerase	DNA Damage/DNA Repair
	Telomease-IN-1是一种端粒酶抑制剂（IC50：0.19μM）。Telomease-IN-1通过ER 过度反应（EOR）的内质网应激（ERS）激活hTERT 的表达，然后诱导ERS，导致细胞凋亡。Telomease-IN-1通过表达下游信号分子包括CHOP（CAAT /增强子结合蛋白同源蛋白））和线粒体凋亡途径，导致细胞增殖受到抑制。Telomease-IN-1对端粒酶具有较高的抑制活性，对SMMC-7721细胞具有较高的抗增殖能力，对人正常肝细胞无明显毒性作用。Telomease-IN-1 在异种移植肿瘤模型表现出抗肿瘤活性。
T35610	2,5-dimethyl Celecoxib	Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells
	2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂，mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。
T26752	BC12 BC 12,BC-12	Others	Others
	BC12 exhibits unusually potent immunomodulatory actions on T lymphocyte function, including inhibition of T cell proliferation and IL-2 cytokine production.
T38720	SR-31747 free base	Others	Others
	SR-31747 free base is an immunosuppressive and anti-inflammatory sigma ligand that efficiently inhibits cell proliferation through the inhibition of sterol isomerase activity.
T29176	YKL-04-085 YKL 04085,YKL04-085,YKL 04-085,YKL-04085	Others	Others
	YKL-04-085 is a potent inhibitor of viral translation. YKL-04-085 has cellular antiviral activity at 35-fold lower concentrations relative to inhibition of host-cell proliferation. YKL-04-085 demonstrated good inhibition of translation of the DENV2(GVD) r
T26200	Somatostatin RC 102 Somatostatin RC102,Somatostatin-RC-102,Somatostatin RC-102	Others	Others
	Somatostatin RC 102 is a peptide hormone. It regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
T21298	SNS-314 SNS-314 free base,SNS314,SNS 314	Others	Others
	SNS-314, a synthetic small molecule Aurora kinase (AK) inhibitor with potential antineoplastic activity, selectively binds and inhibits AKs A and B, resulting in the inhibition of cell division and proliferation in tumor cells that overexpress AKs.
T30508	BMS-243117 UNII-MBE6KWV0QI,CHEMBL67237,MBE6KWV0QI	Others	Others
	BMS-243117 is an effective selective LCK inhibitor with good cell activity (IC(50)=1.1 microM) and inhibition of T cell proliferation, which has great potential for therapeutic immunosuppression and the treatment of diseases such as rheumatoid arthritis a
T68546	PF-00337210	Others	Others
	PF-00337210 is an orally available ATP-competitive inhibitor of the vascular endothelial growth factor receptor type 2 (VEGFR2), with potential anti-angiogenesis and antineoplastic activities. Upon administration, the VEGFR2 tyrosine kinase inhibitor PF-00337210 selectively binds to VEGFR2 and prevents its phosphorylation which may result in an inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and may even...
T70152	Miransertib mesylate	Others	Others
	Miransertib mesylate is a selective AKT inhibitor that binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may result in reduction in tumor cell proliferation and the induction of tumor cell apoptosis.
T8082	NSC745887	Others	Others
	NSC745887 (compound 25) 是一种抗癌剂, 在所有 60 种癌细胞系中均表现出剂量依赖性的增殖抑制作用。
T10875	CP5V	Others; PROTACs	Others; PROTAC
	CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation.
T70018	Apricoxib	Others	Others
	Apricoxib, also known as Benzenesulfonamide 42(4ethoxyphenyl)4methyl1Hpyrrol1yl, is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. COX-related...
T71232	Alisertib sodium hydrate	Others	Others
	Alisertib sodium hydrate is a salt of Alisertib --- an inhibitor of Aurora A kinase with potential antineoplastic activity. Alisertib binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation.
T70198	Atrasentan sodium	Others	Others
	Atrasentan, also known as ABT-627, is a orally available ETA receptor antagonist with potential antineoplastic activity. As a selective antagonist of the endothelin-A (ETA) receptor, atrasentan binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.
T81128	Sontigidomide	Others	Others
	Sontigidomide（Compound 5）是一种抗肿瘤化合物，能在1 μM浓度下显著抑制MOLM-13细胞增殖，3天内抑制率超过80%。
T60996	SDR-04	Others	Others
	SDR-04 对BRD4-BD1 表现出很强的亲和力和抑制活性。SDR-04 是一种BET 抑制剂，可有效抑制 MV4;11 癌细胞系的增殖。
T60479	NSC 698600	Others	Others
	NSC 698600 是一种有效的 PCAF（p300/CBP 相关因子）抑制剂，IC50值为 6.51 μM，显示出良好的癌细胞增殖抑制活性。
T69723	Taminadenant mesylate	Others	Others
	Taminadenant, also known as PBF-509 and NIR-178, is a potent and orally active adenosine A2A receptor antagonist with potential antineoplastic activity. PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell sur...
T25716L	Liarozole HCl R75251,Liarozole hydrochloride,R 75251,R-75251	Others	Others
	Liarozole HCl is a benzimidazole derivative with antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits CYP450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, leading to an increase in endogenous ATRA production,
T70994	TAK-659 HCl	Others	Others
	TAK-659 is an inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Spleen tyrosine kinase inhibitor TAK-659 may inhibit the activity of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Note: TAK-659 free base is less stable. This product is supplied as dihydrochloride form.
T79782	FPR1 antagonist 2	Others	Others
	FPR1 antagonist 2 (compound 25b)为FPR1拮抗剂，IC50值70 nM。该化合物综合影响细胞增殖与凋亡，抑制细胞生长，降低细胞迁移，并促进血管生成。
T70876	KW-2450 Tosylate	Others	Others
	KW-2450 Tosylate is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 Tosylate selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in t...
T74921	Antiproliferative agent-12	Others	Others
	Antiproliferative agent-10 (compound 1) 是一种钌(II)-三吡唑基甲烷抗肿瘤复合物，能够通过阻断线粒体钙吸收来抑制癌细胞增殖。
T79781	FPR1 antagonist 1	Others	Others
	FPR1 antagonist 1 (compound 24a)作为一种FPR1拮抗剂，具有25 nM的IC50值。该化合物抑制细胞增殖与凋亡，减少细胞迁移，并诱导血管生成。
T69985	Lifirafenib HCl	Others	Others
	Lifirafenib, also known as Beigene-283, is a Novel potent and selective RAF Kinase and EGFR inhibitor. BGB-283-displays Potent Antitumor Activity in B-RAF Mutated Colorectal Cancers. In vitro, BGB-283 potently inhibits B-RAFV600E-activated ERK phosphorylation and cell proliferation. It demonstrates selective cytotoxicity and preferentially inhibits proliferation of cancer cells harbouring B-RAFV600E and EGFR mutation/amplification. In B-RAFV600E CRC cell lines, BGB-283 effectively inhibits the ...
T72956	Darizmetinib HRX-0215	Antiviral; MAPK	Immunology/Inflammation; MAPK
	Darizmetinib (HRX-0215) 是一种MKK4抑制剂，MKK4 的抑制导致 MKK7 和 JNK1 信号通路的增强，进而激活转录因子 ATF2 和 ELK1，促进细胞增殖和肝再生。
T70275	PAT-347	Others	Others
	PAT-347 is a potent Autotaxin Inhibitor. Autotaxin (ATX) is a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. The ATX-LPA signaling pathway is implicated in cell survival, migration, and proliferation; thus, the inhibition of ATX is a recognized therapeutic target for a number of diseases including fibrotic diseases, cancer, and inflammation, among others.
T68760	Luminespib mesylate	Others	Others
	Luminespib, also known as AUY-922, NVP-AUY922, VER52296, is a derivative of 4,5-diarylisoxazole and a third-generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90 inhibitor AUY922 has been shown to bind with high affinity to and inhibit Hsp90, resulting in the proteasomal degradation of oncogenic client proteins; the inhibition of cell proliferation; and the elevation of heat shock protein 72 (Hsp72) in a wide range of human tumor cell lines.
T71188	LY2780301	Others	Others
	LY2780301 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway, thereby leading to inhibition of cell proliferation and the induction of apoptosis in tumor cells. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signa...

化合物

Cat.No: T2051

Synonym: FLT3-IN-1,FLT3-IN-1

Target: FLT

Cat.No: T4235

Synonym: FGF-401

Target: FGFR

Cat.No: T6831

Synonym: Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359,依曲替酯

Target: Apoptosis, Others

Cat.No: T3352

Target: cholecystokinin, Casein Kinase, Pim, CDK

Cat.No: T6017

Synonym: OSI-906,林西替尼

Target: IGF-1R

Cat.No: T3623

Synonym: 可美替尼,考比替尼,RG7420,XL518,GDC-0973

Target: Apoptosis, MEK

Cat.No: T1849

Synonym: CYT11387,CYT387,LM-1149

Target: Apoptosis, JAK, Autophagy

Icotinib Hydrochloride

Cat.No: T2307

Synonym: 埃克替尼盐酸盐,盐酸埃克替尼,BPI-2009H

Target: EGFR

Cat.No: T12831L

Target: PI3K, Autophagy

Cat.No: T6334

Synonym: AP23573,Deforolimus,MK-8669

Target: mTOR, Autophagy

Cat.No: T1574

Synonym: Arcoxia,MK-663,Tauxib,L-791456,Nucoxia,Desvenlafaxine,依托考昔

Target: COX

Cat.No: T3211

Synonym: 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱

Target: Others, PKC

KW-2450 free base

Cat.No: T68405

Target: IGF-1R

Cat.No: T11096

Target: NF-κB

Neuroprotective agent 1

Cat.No: T50107

Target: Others

Bomedemstat ditosylate

Cat.No: T70008

Synonym: MK-3543 ditosylate,IMG-7289 ditosylate

Target: Apoptosis, Histone Demethylase

Cat.No: T1185

Synonym: MK 966,罗非昔布,罗非考昔,MK-0966

Target: COX

Cat.No: T3626

Synonym: ACP-196,阿可替尼

Target: BTK

Cat.No: T14884

Target: Others, Dehydrogenase

Cat.No: T3630

Synonym: RVT-601,瑞卢戈利,TAK-385

Target: GNRH Receptor

Telomerase-IN-1

Cat.No: T12009

Target: Telomerase

2,5-dimethyl Celecoxib

Cat.No: T35610

Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor

Cat.No: T26752

Synonym: BC 12,BC-12

Target: Others

SR-31747 free base

Cat.No: T38720

Target: Others

Cat.No: T29176

Synonym: YKL 04085,YKL04-085,YKL 04-085,YKL-04085

Target: Others

Somatostatin RC 102

Cat.No: T26200

Synonym: Somatostatin RC102,Somatostatin-RC-102,Somatostatin RC-102

Target: Others

Cat.No: T21298

Synonym: SNS-314 free base,SNS314,SNS 314

Target: Others

Cat.No: T30508

Synonym: UNII-MBE6KWV0QI,CHEMBL67237,MBE6KWV0QI

Target: Others

Cat.No: T68546

Target: Others

Miransertib mesylate

Cat.No: T70152

Target: Others

Cat.No: T8082

Target: Others

Cat.No: T10875

Target: Others, PROTACs

Cat.No: T70018

Target: Others

Alisertib sodium hydrate

Cat.No: T71232

Target: Others

Atrasentan sodium

Cat.No: T70198

Target: Others

Cat.No: T81128

Target: Others

Cat.No: T60996

Target: Others

Cat.No: T60479

Target: Others

Taminadenant mesylate

Cat.No: T69723

Target: Others

Cat.No: T25716L

Synonym: R75251,Liarozole hydrochloride,R 75251,R-75251

Target: Others

Cat.No: T70994

Target: Others

FPR1 antagonist 2

Cat.No: T79782

Target: Others

KW-2450 Tosylate

Cat.No: T70876

Target: Others

Antiproliferative agent-12

Cat.No: T74921

Target: Others

FPR1 antagonist 1

Cat.No: T79781

Target: Others

Lifirafenib HCl

Cat.No: T69985

Target: Others

Cat.No: T72956

Synonym: HRX-0215

Target: Antiviral, MAPK

Cat.No: T70275

Target: Others

Luminespib mesylate

Cat.No: T68760

Target: Others

Cat.No: T71188

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5724	Neogambogic acid neo-gambogic acid,新藤黄酸	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Neogambogic acid 是藤黄的有效成分，可诱导细胞凋亡并具有抗癌作用。它有效抑制耐甲氧西林的金黄色葡萄球菌。
TN1516	Cnidicin 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮	NOS; NO Synthase	Immunology/Inflammation
	Cnidicin 是一种香豆素，对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。
T3877	Esculentoside A	NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Esculentoside A 是一种三萜皂苷，从商陆根部分离得到。它在具有抗炎活性，对环氧合酶-2 具有选择性抑制活性。它通过抑制NF-κB 和丝裂原活化蛋白激酶信号通路抑制 LPS 诱导的急性肺损伤中的炎症反应。
T5S0527	Rhodojaponin III 闹羊花素 Ⅲ,闹羊花毒素III	Others	Others
	Rhodojaponin III 是二萜类化合物，提取于Rhododendron molle 叶子，具有抗炎作用。
T3S0153	Xanthatin 苍耳亭,叶黄制菌素	Apoptosis; VEGFR; Lipoxygenase; Wnt/beta-catenin; Antibacterial	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Metabolism; Microbiology/Virology; Stem Cells; Tyrosine Kinase/Adaptors
	Xanthatin 是一种从Xanthium strumarium 叶子中提取的天然产物，可诱导细胞凋亡。它抑制布鲁氏菌的IC50值为 2.63 μg/ mL，对寄生虫特异性锥虫硫磷还原酶具有不可逆的弱抑制作用。它通过抑制PGE2的合成和 5-脂氧合酶的活性而显示出抗炎活性。
T6S1141	Ganoderic acid A 灵芝酸 A,灵芝酸A	Apoptosis; NF-κB; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Metabolism; NF-κB
	Ganoderic acid A 能够抑制 JAK-STAT3信号通路，也能抑制细胞增殖，存活率和 ROS。它对人骨肉瘤 HOS 和MG-63细胞具有增殖抑制、凋亡和侵袭抑制作用。
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T2836	Isorhamnetin 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin	MEK; PI3K; Endogenous Metabolite	MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮，可通过抑制MEK1和PI3K 来抑制皮肤癌。
TN3972	Epimedokoreanin B	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Epimedokoreanin B （EKB）是一种从韩国淫羊藿中分离出的异戊烯化类黄酮，在人非小细胞肺癌（NSCLC）A549和NCI-H292细胞中展现出抗癌活性。Epimedokoreanin B 还具有抗炎和抗菌活性，可有清除 DPPH 自由基的活性，能以剂量依赖的方式抑制 MCF-7 和 HepG2 的增殖。Epimedokoreanin B 能显著抑制 N (δ) -（羧甲基）赖氨酸（CML）和 N (Ï) -（羧甲基）精氨酸（CMA）的形成，可通过抑制高级糖化终产物（AGEs）预防糖尿病的临床并发症。
T11363	Ganoderic acid F	Others	Others
	Ganoderic acid F 是一种灵芝酸。它具有抗肿瘤和抗转移的活性，与抑制血管生成和涉及细胞增殖和细胞死亡，致癌作用，氧化应激，钙信号传导和内质网应激的蛋白质改变等机制相关。
TN6586	12-Oleanene-3,6-diol
	12-Oleanene-3,6-diol has antitumor activity, it can induce apoptosis and has inhibition effect on the proliferation in RKO cell line.
TN4239	Hydroxytanshinone IIA	Others	Others
	Hydroxytanshinone ⅡA has good antiproliferative effect on SGC-7901,HeLa, and HepG 2 cell, the values of IC50 are 4.18, 6.08 and10.20 uM, respectively; it has tumor cell proliferation inhibition significantly stronger than the tanshinoneⅡA.
T70495	Scytonemin	Others	Others
	Scytonemin is a biological pigment synthesized by many strains of cyanobacteria, including Calothrix sp., Lyngbya aestuarii, and others. Scytonemin is also a potent PKL1 inhibitor, which inhibits cell proliferation and arrests cell cycle through downregulating Plk1 activity in many cancel cells. Scytonemin was able to inhibit the proliferation of three myeloma cells in a dose-dependent manner, while U266 was the most sensitive one to scytonemin. Scytonemin , representing a novel Plk1 inhibitor, ...
TN1428	(+)-Balanophonin	Antioxidant; AChE	Neuroscience; oxidation-reduction
	(+)-Balanophonin 是一种从 Passiflora edulis 分离得到的天然酚类化合物，具有抗氧化、抗炎、抗癌和抗神经退行性活性，抑制胆碱酯酶，对 OPM2 和 RPMI-8226 细胞增殖有边际抑制作用。
T75704	Isoharringtonine	Others	Others
	Isoharringtonine，一种从Cephalotaxus koreanaNakai 纯化得到的天然生物碱，具有抑制癌细胞增殖和迁移的能力，同时能诱导癌细胞(apoptosis)。该化合物在癌症研究中应用。
TN4490	Manassantin B	ERK; BCL; p38 MAPK; TNF; NF-κB; JNK; STAT; Antifection	Apoptosis; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells
	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in pa...
T3229	Cytochalasin D	ATPase; p38 MAPK; Calcium Channel; Akt; PI3K	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit
TN3364	Agrimonolide	Apoptosis; Dehydrogenase; p38 MAPK; ROS; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; MAPK; Metabolism; Stem Cells
	Agrimonolide 是一种来自异香豆素的化合物，主要存在于草药Agrimonia pilosa Ledeb 中，具有显著的生物活性。Agrimonolide 通过抑制脂多糖（LPS）诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平，可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1，对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是，Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制，同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡，同时增加活性氧（ROS）和总铁的水平。Agrimonolide 很容易穿过血脑屏障，表明其在神经系统疾病的治疗应用方面具有潜力。

天然产物

Neogambogic acid

Cat.No: T5724

Synonym: neo-gambogic acid,新藤黄酸

Target: Apoptosis, Others, Antibacterial

Cat.No: TN1516

Synonym: 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮

Target: NOS, NO Synthase

Esculentoside A

Cat.No: T3877

Target: NF-κB, COX

Rhodojaponin III

Cat.No: T5S0527

Synonym: 闹羊花素 Ⅲ,闹羊花毒素III

Target: Others

Cat.No: T3S0153

Synonym: 苍耳亭,叶黄制菌素

Target: Apoptosis, VEGFR, Lipoxygenase, Wnt/beta-catenin, Antibacterial

Ganoderic acid A

Cat.No: T6S1141

Synonym: 灵芝酸 A,灵芝酸A

Target: Apoptosis, NF-κB, Endogenous Metabolite, Autophagy

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Cat.No: T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Epimedokoreanin B

Cat.No: TN3972

Target: Apoptosis, Others, Antibacterial

Ganoderic acid F

Cat.No: T11363

Target: Others

12-Oleanene-3,6-diol

Cat.No: TN6586

Hydroxytanshinone IIA

Cat.No: TN4239

Target: Others

Cat.No: T70495

Target: Others

(+)-Balanophonin

Cat.No: TN1428

Target: Antioxidant, AChE

Isoharringtonine

Cat.No: T75704

Target: Others

Cat.No: TN4490

Target: ERK, BCL, p38 MAPK, TNF, NF-κB, JNK, STAT, Antifection

Cat.No: T3229

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

Cat.No: TN3364

Target: Apoptosis, Dehydrogenase, p38 MAPK, ROS, JAK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02483	ATP citrate lyase/ACLY Protein, Human, Recombinant (His) ATPCL,ACL,ATP citrate lyase,CLATP	Human	Baculovirus Insect Cells
	ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP citrate lyase is responsible for catalyzing the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, along with the hydrolysis of ATP. A definitive role for ATP citrate lyase in tumorigenesis has emerged from ATP citrate lyase RNAi and chemical inhibitor studies, show...
TMPY-04830	GAS6 Protein, Mouse, Recombinant (His) growth arrest-specific 6,Gas-6	Mouse	HEK293 Cells
	The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor...
TMPY-02219	Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His) NS1 Protein	H1N1	E. coli
	The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast As...
TMPY-05176	AMH Protein, Human, Recombinant (His) MIS,anti-Mullerian hormone,MIF	Human	HEK293 Cells
	Anti-Mullerian hormone (AMH), a member of the TGF-beta superfamily, is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and the FSH-dependent development of follicles. BMP15 up-regulates the transcription of AMH and that the inhibition of p38 MAPK decreases the BMP15-induced expression of AMH and SOX9, suggesting that BMP15 up-regulates the expression of AMH via the p38 MAPK signaling pathway, and thi...
TMPH-01658	MAGEA4 Protein, Human, Recombinant (His) MAGEA4,Melanoma-associated antigen 4,MAGE-4 antigen,MAGE-41 ...	Human	HEK293 Cells
	Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis.
TMPH-01659	MAGEA4 Protein, Human, Recombinant (A173T, His & Myc) MAGE-41 antigen,MAGE-4 antigen,Melanoma-associated antigen 4...	Human	E. coli
	Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis.
TMPJ-01436	MKI67 Protein, Human, Recombinant (GST) Ki-67,Antigen Ki67,MKI67,KIA,antigen KI-67,MIB-1,MIB-,Ki67,P...	Human	E. coli
	MKI67 also also known as Ki67, is a 350-400 kDa nuclear protein that belongs to a molecular group comprised of mitotic chromosome-associated proteins. MKI67 contains 1 FHA domain and plays a key role in cell proliferation. MKI67 is contextually expressed, being potentially found in all cells that are not in the Go phase of the cell cycle. Thus, MKI67 qualifies as a cell proliferation marker. It is also associated with ribosomal RNA transcription. Inactivation of antigen MKI67 leads to inhibition...
TMPH-01642	MELK Protein, Human, Recombinant (His & Myc) Protein kinase Eg3,Tyrosine-protein kinase MELK,Protein kina...	Human	E. coli
	Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. ...
TMPH-01341	FILIP1L Protein, Human, Recombinant (His) FILIP1L,Protein down-regulated in ovarian cancer 1,130 kDa G...	Human	E. coli
	Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. FILIP1L Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.6 kDa and the accession number is Q4L180.
TMPK-01045	IL-20RA Protein, Mouse, Recombinant (hFc) IL-20R1,CRF2-8,IL-20R-alpha,IL-20RA,IL-20R-α,FLJ40993,ZcytoR...	Mouse	HEK293 Cells
	IL-20RA was highly expressed in the tumor tissue of CRC and related to the advanced stage.IL-20RA was involved in regulating oncogenic and immune pathways and affecting the expression of genes related to cell proliferation and immune evasion in CRC.Super-enhancer inhibition by JQ-1 or iBET-151 suppressed the growth of tumor cells and inhibited the expression of IL-20RA.
TMPJ-01155	PDCD4 Protein, Human, Recombinant (His) Programmed Cell Death Protein 4,Protein 197/15a,Neo...	Human	E. coli
	Programmed Cell Death Protein 4 (PDCD4) is a member of the PDCD4 family. PDCD4 and EIF4A1 form a heterotrimer. One molecule of PDCD4 binds two molecules of EIF4A1. PDCD4 takes part in apoptosis via inhibiting translation initiation and cap-dependent translation.PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer. Overexpression of PDCD4 in carc...
TMPJ-01456	Mucin-17/MUC17 Protein, Human, Recombinant (His) Mucin-17, MUC-17, MUC17, MUC3, MUC-3	Human	HEK293 Cells
	Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin17 (MUC17) was more highly expressed in gastric cancer (GC) specimens, with favourable prognosis for patients. And that p38 signalling is a key factor involved in MUC17-mediated inhibition of GC cell proliferation and protection against inflammatory stimulation, MUC17 upregulates the expression ...
TMPY-00519	Gastrokine 1 Protein, Human, Recombinant (His) UNQ489/PRO1005,CA11,foveolin,BRICD1,AMP18,gastrokine 1,FOV	Human	Baculovirus Insect Cells
	Gastrokine 1 (GKN1) belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. GKN1 is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in gastric cancer. GKN1-mediated inhibition of APP processing might represent a new approach for the prevention and therapy of Alzheimer's disease (AD). In the presence of GKN2, GKN1 loses its ability to decrease cell proliferation, induce apoptosis, and inhibit epigenetic alterati...
TMPY-02398	TLE3 Protein, Human, Recombinant (aa 484-772, GST) transducin-like enhancer of split 3,GRG3,ESG3,HsT18976,ESG	Human	E. coli
	The association between high TLE3 expression and a favorable response to taxane-containing chemotherapy regimens was validated in patients with non-serous ovarian cancer. That TLE3 expression may serve as a marker of chemosensitivity in taxane-treated patients with non-serous histologies. Transducin-like enhancer of Split3 (TLE3) serves as a transcriptional corepressor during cell differentiation and shows multiple roles in different kinds of cancers. TLE3 repressed CRC proliferation partly thro...
TMPY-02198	ILKAP Protein, Human, Recombinant (His) ILKAP3,PP2C-δ,PP2C-DELTA,integrin-linked kinase-associated s...	Human	HEK293 Cells
	Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a cytoplasm protein that belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest levels expressed in striated muscle. Much lower levels are evident in various smooth muscle tissues. ILKAP may play a role in the regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferat...
TMPY-03105	Ki67/MKI67 Protein, Human, Recombinant (GST) MIB-1,PPP1R105,marker of proliferation Ki-67,MIB-,K...	Human	E. coli
	MKI67 contains 1 FHA domain and plays a key role in cell proliferation. During interphase, the MKI67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. MKI67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells. MKI67 is an excellent marker to determine the growth fraction of a given cell population. The fraction of MKI67-positive tu...
TMPY-04899	OGN/Osteoglycin Protein, Human, Recombinant (His) OIF,OG,osteoglycin,SLRR3A	Human	HEK293 Cells
	OGN (Osteoglycin) is a Protein Coding gene. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. It belongs to the small leucine-rich proteoglycan (SLRP) family. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor-beta and may regulate osteoblast differentiation. OGN is broadly expressed in the gall bladder, endometrium, and other tissues. OGN reduced Zeb-1 expression via EGFR/Akt leading to inhibition of epith...
TMPJ-00916	TIMP-2 Protein, Mouse, Recombinant (His) metalloproteinase inhibitor 2,Tissue inhibitor of metallopro...	Mouse	HEK293 Cells
	Mouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family; TIMP‑1, TIMP‑2, TIMP‑3, and TIMP‑4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversi...
TMPY-01165	FZD1/Frizzled 1 Protein, Mouse, Recombinant (His) Fzd1,AW227548,frizzled class receptor 1,FZ-1,Fz1	Mouse	HEK293 Cells
	Frizzled-1, also known as FZD1, belongs to theG-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. FZD1 is expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signalin...
TMPY-00920	SFRP2 Protein, Mouse, Recombinant (His) secreted frizzled-related protein 2,AI851596,Sdf5	Mouse	HEK293 Cells
	The Secreted frizzled-related protein (SFRP) family consists of five secreted glycoproteins in humans (SFRP1~5) that act as extracellular signaling ligands. Each SFRP is approximately 3 amino acids in length and contains a cysteine-rich domain (CRD) that shares 3-5% sequence homology with the CRD of Frizzled (Fz) receptors, a putative signal sequence, and a conserved hydrophilic carboxy-terminal domain. SFRPs are able to bind Wnt proteins and Fz receptors in the extracellular compartment. The in...
TMPY-03795	EIF5A2 Protein, Human, Recombinant (His) eIF5AII,eukaryotic translation initiation factor 5A2,EIF-5A2	Human	E. coli
	Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted in the downregulation of the tumorigenic proteins, apoptosis regulator Bcl-2 and myc proto-oncogene protein, and upregulation of E-cadherin, suggesting that EIF5A2 promotes proliferation and metastasis through these proteins. EIF5A2 may therefore serve as a novel therapeutic targe...
TMPH-02217	SMARCA4 Protein, Human, Recombinant (His) Transcription activator BRG1,Protein brahma homolog 1,SWI/SN...	Human	P. pastoris (Yeast)
	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor compl...

重组蛋白

ATP citrate lyase/ACLY Protein, Human, Recombinant (His)

Cat.No: TMPY-02483

Species: Human

Expression System: Baculovirus Insect Cells

GAS6 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04830

Species: Mouse

Expression System: HEK293 Cells

Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)

Cat.No: TMPY-02219

Species: H1N1

Expression System: E. coli

AMH Protein, Human, Recombinant (His)

Cat.No: TMPY-05176

Species: Human

Expression System: HEK293 Cells

MAGEA4 Protein, Human, Recombinant (His)

Cat.No: TMPH-01658

Species: Human

Expression System: HEK293 Cells

MAGEA4 Protein, Human, Recombinant (A173T, His & Myc)

Cat.No: TMPH-01659

Species: Human

Expression System: E. coli

MKI67 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01436

Species: Human

Expression System: E. coli

MELK Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01642

Species: Human

Expression System: E. coli

FILIP1L Protein, Human, Recombinant (His)

Cat.No: TMPH-01341

Species: Human

Expression System: E. coli

IL-20RA Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01045

Species: Mouse

Expression System: HEK293 Cells

PDCD4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01155

Species: Human

Expression System: E. coli

Mucin-17/MUC17 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01456

Species: Human

Expression System: HEK293 Cells

Gastrokine 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00519

Species: Human

Expression System: Baculovirus Insect Cells

TLE3 Protein, Human, Recombinant (aa 484-772, GST)

Cat.No: TMPY-02398

Species: Human

Expression System: E. coli

ILKAP Protein, Human, Recombinant (His)

Cat.No: TMPY-02198

Species: Human

Expression System: HEK293 Cells

Ki67/MKI67 Protein, Human, Recombinant (GST)

Cat.No: TMPY-03105

Species: Human

Expression System: E. coli

OGN/Osteoglycin Protein, Human, Recombinant (His)

Cat.No: TMPY-04899

Species: Human

Expression System: HEK293 Cells

TIMP-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00916

Species: Mouse

Expression System: HEK293 Cells

FZD1/Frizzled 1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01165

Species: Mouse

Expression System: HEK293 Cells

SFRP2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00920

Species: Mouse

Expression System: HEK293 Cells

EIF5A2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03795

Species: Human

Expression System: E. coli

SMARCA4 Protein, Human, Recombinant (His)

Cat.No: TMPH-02217

Species: Human

Expression System: P. pastoris (Yeast)

Cat. No.	Product Name	Target	Signaling Pathways
T70808	Cabazitaxel-d6
	Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance...
TMIH-0065	Acalabrutinib-d4
	Acalabrutinib-d4 是 Acalabrutinib 的氘代化合物。Acalabrutinib 的 CAS 号为 1420477-60-6。Acalabrutinib 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。
TMIJ-0268	Relugolix-d6
	Relugolix-d6 是 Relugolix 的氘代化合物。Relugolix 的 CAS 号为 737789-87-6。Relugolix 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的IC50值分别为0.33 nM和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。

同位素标记化合物

Cat.No: T70808

Acalabrutinib-d4

Cat.No: TMIH-0065

Cat.No: TMIJ-0268

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