首页工具

登录

搜索结果

Search Results for " anti-metabolic "

Targets Recommended: Apoptosis Others Fatty Acid Synthase

42

抑制剂 & 化合物

14

天然产物

10

化合物库

5

重组蛋白

2

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name
L2130	抗癌细胞代谢库		1268 compounds
	1268 种癌细胞代谢相关的生物活性小分子化合物的特有集合，用于肿瘤相关的研究以及抗肿瘤药物的筛选，用于高通量、高内涵筛选；
L5500	毒性化合物库		262 compounds
	262 个细胞毒性化合物的特有集合，可用于高通量、高内涵筛选。
L7100	抗肥胖化合物库		2247 compounds
	2247 个抗肥胖化合物的独特集合，可用于高通量筛选和高内涵筛选；
L5100	含氟化合物库		574 compounds
	574 个含氟化合物的独特集合，可用于高通量筛选和高内涵筛选；
L3200	自噬库		1248 compounds
	1248 种细胞自噬相关的生物活性小分子化合物的特有集合，用于自噬相关的研究，用于高通量、高内涵筛选；
L9610	环肽库		80 compounds
	80 种环肽分子，可用于高通量和高内涵筛选；
L6600	胃肠炎天然产物库		219 compounds
	219 种胃肠炎相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L9600	多肽分子库		791 compounds
	791 种多肽类分子，可用于多肽药物开发及信号转导通路和作用机制研究；
L6400	海洋天然产物库		144 compounds
	144 种海洋来源的单体化合物，是药物开发、药理研究等领域的有力工具；
L7110	抗高血压化合物库		678 compounds
	678 种高血压相关的小分子，用于高通量和高内涵筛选；

化合物库

抗癌细胞代谢库

Cat.No: L2130

Compounds: 1268

毒性化合物库

Cat.No: L5500

Compounds: 262

抗肥胖化合物库

Cat.No: L7100

Compounds: 2247

含氟化合物库

Cat.No: L5100

Compounds: 574

Cat.No: L3200

Compounds: 1248

Cat.No: L9610

Compounds: 80

胃肠炎天然产物库

Cat.No: L6600

Compounds: 219

多肽分子库

Cat.No: L9600

Compounds: 791

海洋天然产物库

Cat.No: L6400

Compounds: 144

抗高血压化合物库

Cat.No: L7110

Compounds: 678

Cat. No.	Product Name	Target	Signaling Pathways
T0686	Orlistat Ro-18-0647,奥利司他,Tetrahydrolipstatin	Apoptosis; Others; Fatty Acid Synthase	Apoptosis; Metabolism; Others
	Orlistat (Tetrahydrolipstatin) 是一种不可逆的胰腺和胃脂肪酶抑制剂，也是一种脂肪酸合成酶抑制剂，可研究肥胖症，具有抗动脉粥样硬化作用。
T26701	AZ12216052 AZ 12216052,AZ-12216052	GPR	Endocrinology/Hormones; GPCR/G Protein
	AZ12216052 是一种 GRP8 拮抗剂，具有抗焦虑和抗炎活性，可用于研究肥胖和代谢紊乱。
T27019	PSB-CB5 CID-85469571,GPR18-IN-32	GPR	Endocrinology/Hormones; GPCR/G Protein
	PSB-CB5 (GPR18-IN-32)2 是一种 GRP18 拮抗剂，具有抗炎活性，可用于研究肥胖和代谢紊乱。
T13159	Tiludronate disodium Tiludronic Acid disodium,Tiludronic acid disodium	ATPase	Membrane transporter/Ion channel
	Tiludronate disodium (Tiludronic acid disodium) 是一种破骨细胞液泡 H(+)-ATPase 抑制剂，具有抗骨吸收和抗炎特性。 Tiludronate disodium 可用于有关代谢性骨病的研究。
T1163	Betamethasone valerate Betnovate,倍他米松戊酸酯,Betaderm,Betamethasone 17-valerate,Luxiq	Glucocorticoid Receptor	Endocrinology/Hormones
	Betamethasone valerate (Luxiq) 的 17 戊酸酯，是一种具有抗炎活性的局部皮质类固醇。它能够抑制放射标记的糖皮质激素地塞米松与人表皮(IC50:5 nM)及小鼠皮肤(IC50:6 nM)的结合。它可用于研究复发性口疮。
T0977	Medrysone Gimeracil,6α-Methyl-11β-hydroxyprogesterone,6A-甲基-11B-羟孕酮,甲羟松	Glucocorticoid Receptor; Others	Endocrinology/Hormones; Others
	Medrysone (6α-Methyl-11β-hydroxyprogesterone) 是局部合成的糖皮质激素，具有代谢、抗炎和抗过敏特性，有潜力用于眼科的眼炎症研究。
T1559	Betamethasone dipropionate Diprolene AF,SCH 11460,二丙酸倍他米松,Betamethasone 17,21-dipropionate,Diprolene,倍他米松二丙酸酯,Diprosone	Glucocorticoid Receptor	Endocrinology/Hormones
	Betamethasone dipropionate (SCH 11460) 是糖皮质激素类固醇，具有免疫抑制、抗炎作用。
T60400	LDCA	Apoptosis; Dehydrogenase	Apoptosis; Metabolism
	LDCA 是一种双hit 代谢调节剂，展现出强大的抗增殖活性。LDCA 能竞争性地抑制LDH-A 酶的活性，改变线粒体的超极化并同时颠覆细胞凋亡。LDCA 在癌细胞中作用明显且不显示出毒性。
T1185	Rofecoxib MK 966,罗非昔布,罗非考昔,MK-0966	COX	Immunology/Inflammation; Neuroscience
	Rofecoxib (MK 966) 是可口服的 COX-2特异性抑制剂，具有抗炎、解热和镇痛特性以及潜在的抗肿瘤特性。在人骨肉瘤细胞和中国仓鼠卵巢细胞中，对人 COX-2 的 IC50值分别为 26 和 18 nM。
T22444	Trimetazidine	Others	Others
	Trimetazidine, an anti-ischemic (anti-anginal) metabolic agent, could improve myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity and results in a reduction in fatty acid oxidation and a stimulation of glucose
T68557	PF-376304	Others	Others
	PF-376304 is a nonspecific PI3K inhibitor under development for anti-inflammatory indications. Phosphoinositide 3-kinase (PI3K) is an enzyme fundamental to the regulation of various metabolic processes.
T75194	N4-(3,3,3-Trifluoropropanoyl)cytidine	Others	Others
	N4-(3,3,3-Trifluoropropanoyl)cytidine 是一种胞嘧啶核苷类似物。胞苷类似物具有抑制 DNA 甲基转移酶的机制 (如 Zebularine)，具有潜在的抗代谢和抗肿瘤活性。
T39037	Tiludronate disodium hemihydrate Tiludronic acid disodium hemihydrate,替鲁膦酸二钠半水合物	Others	Others
	Tiludronate (Tiludronic Acid) disodium hemihydrate is an orally active bisphosphonate compound that functions as an osteoregulator. It is primarily utilized in metabolic bone disorder research. This compound acts as a potent inhibitor of the osteoclast vacuolar H+ -ATPase and possesses antiresorptive and anti-inflammatory properties[4].
T75183	3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine	Others	Others
	3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine 是一种胞嘧啶核苷类似物。胞苷类似物具有抑制 DNA 甲基转移酶的机制 (如 Zebularine)，具有潜在的抗代谢和抗肿瘤活性。
T82952	ATF3 inducer 1	Others	Others
	ATF3 inducer 1, 作为一种高效ATF3诱导剂，能显著提高ATF3蛋白及其mRNA的表达水平，并在小鼠模型中展现出对MetS的抗性活性。
T75032	N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine	Others	Others
	N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine 是一种胞嘧啶核苷类似物。胞苷类似物具有抑制 DNA 甲基转移酶的机制 (如 Zebularine)，具有潜在的抗代谢和抗肿瘤活性。
T61928	Antitubercular agent-25	Others	Others
	Antitubercular agent-25 (Compound 28) 是一种抗结核剂。Antitubercular agent-25抑制细胞外M. tuberculosisH37Rv 的IC50为 0.42 μM，细胞内为 0.20 μM。Antitubercular agent-25代谢稳定性良好。
T78786	MmpL3-IN-3	Others	Others
	MmpL3-IN-3 (Compound 12) 为一种MmpL3抑制剂，对 H37Rv 的最小抑制浓度(MIC)为 0.1 μM。该化合物在小鼠肝微粒体中具有良好稳定性，适用于抗结核研究。
T84420	13-SAHSA	Others	Others
	13-SAHSA, a branched fatty acid ester of hydroxy fatty acids (FAHFAs), has been found to be involved in metabolic regulation, particularly in relation to fasting, high-fat feeding, and insulin sensitivity. This compound is a synthesis of stearic acid and 13-hydroxy stearic acid. Notably, 13-SAHSA levels are found to be moderately increased in the serum of AG4OX mice, which are characterized by their glucose tolerance and expression of the Glut4 glucose transporter specifically in their adipose t...
T73056	Tiludronate Tiludronic acid	Others	Others
	Tiludronate (Tiludronic Acid) 是一种口服活性双膦酸盐，可以起到骨调节作用。Tiludronate 用于代谢性骨疾病的研究。Tiludronate 是破骨细胞空泡 H(+)-ATP 酶的有效抑制剂。
T84424	5-SAHSA	Others	Others
	15-SAHSA, a branched fatty acid ester of hydroxy fatty acids (FAHFAs), is recognized for its involvement in metabolic regulation. This compound comprises stearic acid esterified to 5-hydroxy stearic acid and is notably influenced by dietary changes, such as fasting and high-fat consumption, with a link to insulin sensitivity. SAHSA levels are specifically found to be moderately increased in the serum of AG4OX mice, which are characterized by their glucose tolerance through the overexpression of ...
T70018	Apricoxib	Others	Others
	Apricoxib, also known as Benzenesulfonamide 42(4ethoxyphenyl)4methyl1Hpyrrol1yl, is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. COX-related...
T81967	KY386	Others	Others
	KY386为选择性DHX33 helicase抑制剂，IC50仅19 nM。针对U251-MG细胞（DHX33过表达癌细胞株）的抑制作用表现出相似效力，IC50为20 nM。该化合物展现出显著的抗癌活性及中等的代谢稳定性。
T84407	13-PAHSA	Others	Others
	Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are lipids influenced by dietary changes, playing a crucial role in insulin sensitivity. These compounds typically consist of a C-16 or C-18 fatty acid (for example, palmitoleic, palmitic, oleic, or stearic acid) linked to a hydroxy fatty acid with the same carbon chain length. 13-PAHSA, a derivative where palmitic acid is esterified to 13-hydroxy stearic acid, is notably prevalent in the adipose tissue of glucose-tolerant AG4OX mice, wh...
T84422	13-OAHSA	Others	Others
	13-OAHSA, a branched fatty acid ester of hydroxy fatty acids (FAHFAs), results from the esterification of oleic acid to 13-hydroxy stearic acid. It represents a significant component of the FAHFA family, most abundantly expressed in the serum of glucose-tolerant AG4OX mice that exhibit adipose tissue-specific overexpression of the Glut4 glucose transporter. Similar to other FAHFAs which are known to enhance glucose tolerance, stimulate insulin secretion, and exert anti-inflammatory effects, 13-O...
T84429	12-POHSA	Others	Others
	Branched fatty acid esters of hydroxy fatty acids (FAHFAs) have emerged as significant regulators of metabolic processes, influenced by dietary changes such as fasting and high-fat diets, and are linked to improved insulin sensitivity in mice. These compounds typically feature a fatty acid chain, either C-16 or C-18 in length (for example, palmitoleic, palmitic, oleic, or stearic acid), esterified to a hydroxy fatty acid of similar length. A specific FAHFA, 12-POHSA, involves the esterification ...
T36142	10-PAHSA	Others	Others
	10-PAHSA is a newly identified endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). It is a FAHFA in which palmitic acid is esterified to 10-hydroxy stearic acid. Among the FAHFA family members, PAHSAs are the most abundant in the adipose tissue of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue. As other FAHFAs improve glucose tolerance, stimulate insulin secretion, and have anti-...
T79226	AMPK activator 11	Mitochondrial Metabolism	Metabolism
	AMPK activator11 是一种抗肿瘤活性纳米级化合物，有效针对多种CRC。通过激活AMPK及上调OXPHOS（mitochondrial metabolism），该化合物能选择性抑制RKO异种移植物生长，应用于肿瘤和代谢性疾病研究领域。
T10964L	DB1976 dihydrochloride DB1976 hydrochloride,DB1976 2HCl	Apoptosis; NF-κB	Apoptosis; NF-κB
	DB1976 dihydrochloride (DB1976 2HCl) ，一种转录因子 PU.1 抑制剂，具有潜在抗炎活性，可在体内实验中减缓小鼠的炎症和纤维化，改善了葡萄糖稳态和血脂异常。DB1976 dihydrochloride 促进细胞凋亡，可用于研究代谢功能障碍和非酒精性脂肪性肝炎。
T84421	13-POHSA	Others	Others
	13-POHSA (palmitoleic acid esterified to 13-hydroxy stearic acid) is a type of branched fatty acid esters of hydroxy fatty acids (FAHFAs), which have recently been discovered as endogenous lipids whose levels are modulated by fasting and high-fat diets, and are linked to insulin sensitivity in mice. Notably, the concentration of 13-POHSA in the serum significantly increases in glucose tolerant AG4OX mice, a model that overexpresses the Glut4 glucose transporter in adipose tissue, suggesting its ...
T62658	Antifungal agent 22	Others	Others
	Antifungal agent 22 (compound D16) 是一种口服具有活力的、潜在的抗真菌药物 (IC50: 0.5 μg/mL)。Antifungal agent 22 具有血脑屏障通透性，通过破坏真菌细胞膜的完整性杀死C. neoformansH99 细胞。Antifungal agent 22 显示出选择性抗隐球菌活性，具有良好的代谢稳定性和低细胞毒性。
T84387	10-SAHSA	Others	Others
	10-SAHSA, an endogenous lipid recently discovered, is part of the FAHFAs, a group of branched fatty acid esters of hydroxy fatty acids. It specifically consists of stearic acid esterified to 10-hydroxy stearic acid. Notably, PAHSAs, closely related to 10-SAHSA, are significantly present in the adipose tissue of AG4OX mice that are glucose tolerant due to the overexpression of the Glut4 glucose transporter in their adipose tissue. Similar to other FAHFAs, which are known to improve glucose tolera...
T72865	Sofnobrutinib AS-0871	Others	Others
	Sofnobrutinib (AS-0871) 是口服有效、选择性的 BTK 抑制剂，抑制激活和未激活BTK 的IC50分别为 4.2 nM 和 0.39 nM。Sofnobrutinib 也抑制hERG，IC50为 24 μM。Sofnobrutinib 具有良好的代谢稳定性和生物利用度。Sofnobrutinib 的被动皮肤过敏反应低，在胶原诱导的小鼠关节炎模型中具有抗炎作用。
T78873	CTL-12	Others	Others
	CTL-12是一种Fatty Acid Synthase (FASN)抑制剂（IC50: 2.5 μM），能够诱导apoptosis。它使细胞周期在Sub-G1/S期停滞并增加caspase-9和凋亡标志物Bax的表达，同时减少抗凋亡标志物Bcl-xL的水平。CTL-12通过抑制de novo脂肪酸合成，切断了肿瘤细胞的代谢需求，是乳腺癌和结直肠癌研究中的重要工具。
T38049	Glycerophospho-N-Palmitoyl Ethanolamine	Others	Others
	N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. For example, arachidonoyl ethanolamide (AEA) is an endogenous neurotransmitter that evokes cellular responses by activating the cannabinoid receptors, central cannabinoid (CB1) and peripheral cannabinoid (CB2). The different types of NAE are derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-palmitoyl ethanolamine (GP-NPEA) is the metabo...
T84386	10-OAHSA	Others	Others
	10-OAHSA is a newly discovered endogenous lipid categorized within the group of branched fatty acid esters of hydroxy fatty acids (FAHFAs). This specific FAHFA comprises oleic acid esterified to 10-hydroxy stearic acid. It stands out among its FAHFA counterparts for its potential bioactive properties, similar to other members of its family such as PAHSAs, which are notably prevalent in the adipose tissue of AG4OX mice exhibiting glucose tolerance due to overexpression of the Glut4 glucose transp...
T84425	5-POHSA	Others	Others
	Branched fatty acid esters of hydroxy fatty acids (FAHFAs), endogenous lipids influenced by fasting and high-fat diets, are linked to improved insulin sensitivity in mice. These molecules consist of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) bonded to a C-16 or C-18 hydroxy fatty acid. A specific FAHFA, 5-POHSA, features palmitoleic acid esterified with hydroxy stearic acid at the 5th carbon. Elevated levels of 5-POHSA in the serum of AG4OX mice, which expres...
T38222	N-(α-Linolenoyl) Tyrosine
	Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precurs...
T78872	CTL-06	Others	Others
	CTL-06是一种Fatty Acid Synthase (FASN)抑制剂，具有3 μM的IC50，能够诱发细胞凋亡。CTL-12导致细胞周期在Sub-G1/S期停滞，并增加caspase-9和凋亡标志物Bax的表达，减少抗凋亡标志物Bcl-xL的表达。此外，CTL-12通过抑制脂肪酸的从头合成，剥夺肿瘤细胞代谢所需，主要用于乳腺癌和结直肠癌的研究。
T84428	9-POHSA	Others	Others
	Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are recent discoveries in endogenous lipids that are influenced by dietary changes such as fasting and high-fat diets, showing a link with enhanced insulin sensitivity in mice. These compounds typically feature a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) bound to a hydroxy group on another C-16 or C-18 fatty chain. A specific FAHFA, 9-POHSA, consists of palmitoleic acid connected at the hydroxy stearic...
T35816	ZLY032	Others	Others
	ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 μM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic st...
T37831	CAY10641	Others	Others
	Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from thesn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.1CAY10641 is an inactive alcohol derivative of a highly potent (IC50= 12 nM) cPLA2α inhibitor.2The parent compound demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in...

化合物

Cat.No: T0686

Synonym: Ro-18-0647,奥利司他,Tetrahydrolipstatin

Target: Apoptosis, Others, Fatty Acid Synthase

Cat.No: T26701

Synonym: AZ 12216052,AZ-12216052

Target: GPR

Cat.No: T27019

Synonym: CID-85469571,GPR18-IN-32

Target: GPR

Tiludronate disodium

Cat.No: T13159

Synonym: Tiludronic Acid disodium,Tiludronic acid disodium

Target: ATPase

Betamethasone valerate

Cat.No: T1163

Synonym: Betnovate,倍他米松戊酸酯,Betaderm,Betamethasone 17-valerate,Luxiq

Target: Glucocorticoid Receptor

Cat.No: T0977

Synonym: Gimeracil,6α-Methyl-11β-hydroxyprogesterone,6A-甲基-11B-羟孕酮,甲羟松

Target: Glucocorticoid Receptor, Others

Betamethasone dipropionate

Cat.No: T1559

Synonym: Diprolene AF,SCH 11460,二丙酸倍他米松,Betamethasone 17,21-dipropionate,Diprolene,倍他米松二丙酸酯,Diprosone

Target: Glucocorticoid Receptor

Cat.No: T60400

Target: Apoptosis, Dehydrogenase

Cat.No: T1185

Synonym: MK 966,罗非昔布,罗非考昔,MK-0966

Target: COX

Cat.No: T22444

Target: Others

Cat.No: T68557

Target: Others

N4-(3,3,3-Trifluoropropanoyl)cytidine

Cat.No: T75194

Target: Others

Tiludronate disodium hemihydrate

Cat.No: T39037

Synonym: Tiludronic acid disodium hemihydrate,替鲁膦酸二钠半水合物

Target: Others

3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine

Cat.No: T75183

Target: Others

Cat.No: T82952

Target: Others

N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine

Cat.No: T75032

Target: Others

Antitubercular agent-25

Cat.No: T61928

Target: Others

Cat.No: T78786

Target: Others

Cat.No: T84420

Target: Others

Cat.No: T73056

Synonym: Tiludronic acid

Target: Others

Cat.No: T84424

Target: Others

Cat.No: T70018

Target: Others

Cat.No: T81967

Target: Others

Cat.No: T84407

Target: Others

Cat.No: T84422

Target: Others

Cat.No: T84429

Target: Others

Cat.No: T36142

Target: Others

AMPK activator 11

Cat.No: T79226

Target: Mitochondrial Metabolism

DB1976 dihydrochloride

Cat.No: T10964L

Synonym: DB1976 hydrochloride,DB1976 2HCl

Target: Apoptosis, NF-κB

Cat.No: T84421

Target: Others

Antifungal agent 22

Cat.No: T62658

Target: Others

Cat.No: T84387

Target: Others

Cat.No: T72865

Synonym: AS-0871

Target: Others

Cat.No: T78873

Target: Others

Glycerophospho-N-Palmitoyl Ethanolamine

Cat.No: T38049

Target: Others

Cat.No: T84386

Target: Others

Cat.No: T84425

Target: Others

N-(α-Linolenoyl) Tyrosine

Cat.No: T38222

Cat.No: T78872

Target: Others

Cat.No: T84428

Target: Others

Cat.No: T35816

Target: Others

Cat.No: T37831

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN2121	3,5,7,3′,4′-Pentamethoxyflavone 栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether	Others	Others
	3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) 是一种分离自小花山奈中的多甲氧基黄酮。在分化早期，它可以调控转录因子，促进 3T3-L1 前脂肪细胞形成脂肪。
T3324	Lycorine Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱	Apoptosis; Virus Protease; Antibacterial; AChR; Fatty Acid Synthase	Apoptosis; Metabolism; Microbiology/Virology; Neuroscience
	Lycorine (Narcissine) 是从金眼科植物科中提取的一种天然生物碱。它是一种具有口服活性的SCAP 抑制剂，Kd 值 15.24 nM。它也是黑色素瘤血管生成抑制剂，有用于前列腺癌和代谢疾病的研究潜力。
T3S0289	Araloside X	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane peroxidation induced by oxygen free radi
T6S1683	Demethoxycurcumin Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin	Apoptosis; Antioxidant; Antibacterial; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; oxidation-reduction
	Demethoxycurcumin (Desmethoxycurcumin) 是姜黄素的主要活性成分，有抗炎和抗癌作用。
T3S0381	Chrysophanol 8-O-glucoside	Serine Protease	Proteases/Proteasome
	Chrysophanol 8-O-glucoside 来自Rumex acetosa 根部，具有中等的弹性蛋白酶抑制特性。它具有温和的细胞毒性和抗糖尿病特性，能够在胰岛素刺激的葡萄糖转运途径中发挥代谢作用。
T3669	Curcumenol (+)-Curcumenol,莪术醇	P450	Metabolism
	Curcumenol ((+)-Curcumenol) 提取具有药用价值的 Curcuma zedoaria，是高效的 CYP3A4抑制剂(IC50=12.6 μM)，具有神经抗肿瘤、保护、抗炎、和保肝的作用。它在 LPS 刺激的 BV-2 小胶质细胞中，抑制 Akt 介导的 NF-κB 活化及 p38 MAPK 信号通路。
T2S2173	(E)-Naringenin chalcone Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮	Others	Others
	Naringenin chalcone (Isosalipurpol) 是一种黄酮醇生物合成的中间体，在查耳酮异构酶的作用下，自发代谢成柚皮素。它具有抗炎和抗过敏活性。
T3403	Glabridin 光甘草定,Q-100692,KB-289522,LS-176045	Reactive Oxygen Species; Tyrosinase; GABA Receptor; Antibacterial; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Glabridin (KB-289522) 能够结合并激活PPARγ，EC50值为 6115 nM，是一种从Glycyrrhiza glabra 中分到的异黄烷类天然产物。它具有抗炎、抗菌、抗肾炎、抗氧化、抗肿瘤、抗糖尿病、抗骨质疏松、保护神经、保护心血管、清除自由基等作用。
T5S1172	Tiliroside 银椴甙,Tribuloside,银椴苷；椴树苷	Antioxidant	oxidation-reduction
	Tiliroside (Tribuloside) 是糖苷类黄酮，是 α-淀粉酶的非竞争性抑制剂(Ki:84.2 μM)。它抑制胃肠道中碳水化合物的消化和葡萄糖的吸收，具有抗糖尿病作用。
T4S1637	gamma-Mangostin Normangostin,γ-倒捻子素	Others; 5-HT Receptor	GPCR/G Protein; Neuroscience; Others
	gamma-Mangostin (Normangostin) 是从药用植物山竹的果壳中提纯的一种天然产物，是一种竞争性5-HT2A 受体拮抗剂。它是运甲状腺素蛋白原纤维化抑制剂，与甲状腺素结合位点结合并稳定了 TTR 四聚体，具有抗高血压、预防结肠癌等作用。
T5S1097	Neferine (R)-1,2-Dimethoxyaporphine,(-)-Neferine,甲基莲心碱	Apoptosis; NF-κB; Autophagy	Apoptosis; Autophagy; NF-κB
	Neferine ((-)-Neferine) 是一种双苄基异喹啉类生物碱，可强效抑制NF-κB 激活，具有抗肿瘤活性。
T3794	Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖	Influenza Virus	Microbiology/Virology
	1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中，具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
TN7537	Urdamycin B	Others	Others
	Urdamycin B是一种从Streptomyces fradiae代谢产物中提取的antibiotic，具有抑制真菌和细菌的效能。此外，该化合物对小鼠白血病细胞L1210展示出抗增殖活性，可应用于癌症及细菌、真菌感染的研究。
TN3779	De-O-methyllasiodiplodin	IL Receptor; TNF; ROS; Antifection	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on induced NO production. De-O-methyllasiodiplodin effectively lowers the blood glucose level in d

天然产物

3,5,7,3′,4′-Pentamethoxyflavone

Cat.No: TN2121

Synonym: 栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether

Target: Others

Cat.No: T3324

Synonym: Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱

Target: Apoptosis, Virus Protease, Antibacterial, AChR, Fatty Acid Synthase

Cat.No: T3S0289

Target: Calcium Channel

Demethoxycurcumin

Cat.No: T6S1683

Synonym: Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin

Target: Apoptosis, Antioxidant, Antibacterial, Autophagy

Chrysophanol 8-O-glucoside

Cat.No: T3S0381

Target: Serine Protease

Cat.No: T3669

Synonym: (+)-Curcumenol,莪术醇

Target: P450

(E)-Naringenin chalcone

Cat.No: T2S2173

Synonym: Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮

Target: Others

Cat.No: T3403

Synonym: 光甘草定,Q-100692,KB-289522,LS-176045

Target: Reactive Oxygen Species, Tyrosinase, GABA Receptor, Antibacterial, PPAR

Cat.No: T5S1172

Synonym: 银椴甙,Tribuloside,银椴苷；椴树苷

Target: Antioxidant

gamma-Mangostin

Cat.No: T4S1637

Synonym: Normangostin,γ-倒捻子素

Target: Others, 5-HT Receptor

Cat.No: T5S1097

Synonym: (R)-1,2-Dimethoxyaporphine,(-)-Neferine,甲基莲心碱

Target: Apoptosis, NF-κB, Autophagy

Pentagalloylglucose

Cat.No: T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Target: Influenza Virus

Cat.No: TN7537

Target: Others

De-O-methyllasiodiplodin

Cat.No: TN3779

Target: IL Receptor, TNF, ROS, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03962	AFM Protein, Human, Recombinant (His) afamin,ALBA,ALB2,ALF	Human	HEK293 Cells
	Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin's glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determination. Afamin, a human plasma glycoprotein and putative transporter of hydrophobic molecules, has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. The 2.1-Å crystal structure of...
TMPY-00566	CCL18 Protein, Human, Recombinant (His) PARC,CCL18,CKb7,DC-CK1,chemokine (C-C motif) ligand 18,MIP-4...	Human	P. pastoris (Yeast)
	CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. CCL18 chemokine has an important role in chemokine-mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. (CCL18) is predominantly secreted by M2-tumor associated macrophages (TAMs) a...
TMPY-04554	JNK1 Protein, Human, Recombinant (GST) PRKM8,JNK,JNK-46,JNK21B1/2,JNK1A2,mitogen-activated protein ...	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. The protein kinases JNK1 has been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. It is critically involved in ...
TMPH-01676	Meteorin-like/METRNL Protein, Human, Recombinant (His & SUMO) METRNL,Meteorin-like protein,Subfatin	Human	E. coli
	Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the a...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His) IRF1,Interferon regulatory factor 1	Human	Baculovirus Insect Cells
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired imm...

重组蛋白

AFM Protein, Human, Recombinant (His)

Cat.No: TMPY-03962

Species: Human

Expression System: HEK293 Cells

CCL18 Protein, Human, Recombinant (His)

Cat.No: TMPY-00566

Species: Human

Expression System: P. pastoris (Yeast)

JNK1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04554

Species: Human

Expression System: Baculovirus Insect Cells

Meteorin-like/METRNL Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01676

Species: Human

Expression System: E. coli

IRF1 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01552

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0181	Demethoxy Curcumin-d4
	Demethoxy Curcumin-d4 是 Demethoxy Curcumin 的氘代化合物。Demethoxy Curcumin 的 CAS 号为 22608-11-3。Demethoxycurcumin是姜黄素的主要活性成分，有抗炎和抗癌作用。
TMIJ-0204	Betamethasone-d10 Dipropionate
	Betamethasone-d10 Dipropionate 是 Betamethasone Dipropionate 的氘代化合物。Betamethasone Dipropionate 的 CAS 号为 5593-20-4。Betamethasone dipropionate 是糖皮质激素类固醇，具有免疫抑制、抗炎作用。

同位素标记化合物

Demethoxy Curcumin-d4

Cat.No: TMIH-0181

Betamethasone-d10 Dipropionate

Cat.No: TMIJ-0204

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼