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Search Results for " tnf receptor "

Targets Recommended: TNF

77

抑制剂 & 化合物

28

天然产物

1

化合物库

97

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L9840	抗阿尔茨海默症化合物库		986 compounds
	986 种阿尔茨海默症相关的化合物集合，可用于高通量和高内涵筛选；

化合物库

抗阿尔茨海默症化合物库

Cat.No: L9840

Compounds: 986

Cat. No.	Product Name	Target	Signaling Pathways
T4637	R-7050 TNF-α Antagonist III	TNF	Apoptosis
	R-7050 (TNF-α Antagonist III) 是一种肿瘤坏死因子受体拮抗剂，对 TNFα具有更高选择性。
T4319	Hispidol (Z)-Hispidol	TNF	Apoptosis
	Hispidol ((Z)-Hispidol) 是一种炎症性肠病的潜在治疗剂，可抑制 TNF-α 诱导的单核细胞与结肠上皮细胞的粘附，IC50 为 0.50 μM。
T8692	(Rac)-Benpyrine	TNF	Apoptosis
	(Rac)-Benpyrine 是一种有效且具有口服活性的 TNF-α 抑制剂，是Benpyrine 的外消旋体。它可研究TNF-α介导的炎症和自身免疫性疾病。
T14848	C 87	Others; TNF	Apoptosis; Others
	C 87 是一种小分子 TNF-α 抑制剂。 C 87 直接与 TNFα 结合，有效抑制 TNF-α 诱导的细胞毒性 (IC50 = 8.73 μM)，并有效阻断 TNF-α 触发的信号传导活动。
T9921	Infliximab	TNF	Apoptosis
	Infliximab 是一种与 TNF-α特异性结合的嵌合单克隆 IgG1 抗体，可阻止 TNF-α与 TNFR1和 TNFR2 的相互作用，用于治疗克罗恩病和类风湿性关节炎。
T11096	DRI-C21045	NF-κB	NF-κB
	DRI-C21045 是一种有效的 CD40-CD40L 协同刺激蛋白-蛋白质相互作用的选择性抑制剂，IC50 为 0.17 μM。它显示对 CD40L 诱导的 NF-κB 活化和 B 细胞增殖的浓度依赖性抑制，IC50分别为 17.1 μM 和 4.5 μM。
T2065	Bioymifi DR5 Activator	Apoptosis; TNF	Apoptosis
	Bioymifi (DR5 Activator) 是一种 TRAIL 受体DR5激活剂，与DR5的胞外结构域结合，Kd 为 1.2 μM，它可诱导 DR5 聚集，导致细胞凋亡。
TQ0181	Resatorvid CLI-095,TAK-242,瑞沙托维	TNF; TLR; Autophagy; Interleukin	Apoptosis; Autophagy; Immunology/Inflammation
	Resatorvid (TAK-242) 是一种 Toll 样受体 4 (TLR4) 的抑制剂，具有选择性。Resatorvid 直接与 Cys747 结合，阻止 TLR4 与 TIRAP 结合，从而阻止下游信号转导。Resatorvid 具有抗肿瘤活性、抗炎活性和神经保护作用。
T13951	UCB-9260	TNF	Apoptosis
	UCB-9260 是口服活性小分子，通过稳定三聚体的不对称形式抑制肿瘤坏死因子信号传导。它对肿瘤坏死因子的选择性高于其他超家族成员，并与肿瘤坏死因子结合，其Kd 值为 13 nM。
T12997	SR-318	p38 MAPK; TNF	Apoptosis; MAPK
	SR-318 是p38 MAPK 的选择性抑制剂，对 p38α，p38β 和 p38α/β 的IC50分别为 5 nM，32 nM 和 6.11 μM。它有效抑制全血中TNF-α的释放，IC50为 283 nM。它显示出抗癌和抗炎活性。
T40423	L48H37	Others	Others
	L48H37是Curcumin的一个化学稳定类似物。它对髓系分化蛋白2 (MD2) 表现出强效的抑制性质，作为一个特异性抑制剂。其机制包括抑制LPS-TLR4/MD2的相互作用和信号传导。L48H37主要用于脓血症和肺损伤研究[1]。
T3561	CPI1189 CPI-1189,REN-1189,CPI 1189	TNF	Apoptosis
	CPI1189 (REN-1189) 是 TNF-α 释放抑制剂，具有神经保护作用及抗氧化作用。它可用于研究 HIV 相关神经毒性，具有成为 HIV 相关 CNS 疾病患者神经保护治疗药物的潜能。
T7091	N-Formyl-Met-Leu-Phe fMLP,N-Formyl-MLF	TNF	Apoptosis
	N-Formyl-Met-Leu-Phe (N-Formyl-MLF) 是一种趋化肽和N-甲酰基肽受体的特异性配体，可抑制TNF-alpha 的分泌。
T12493	PK68	Others; RIP kinase	Apoptosis; NF-κB; Others
	PK68 是 II 型受体相互作用激酶 1 (RIPK1, IC50 = 90 nM) 的有效特异性抑制剂。 PK68可用于治疗炎症性疾病和癌症转移的研究。
T8727	TH1020	TLR; Antibacterial	Immunology/Inflammation; Microbiology/Virology
	TH1020 是一种选择性 Toll 样受体 5 /鞭毛蛋白复合拮抗剂，IC50为 0.85 μM。它抑制鞭毛蛋白诱导的TLR5信号传导。
T7001	TIC10 ONC-201	Apoptosis; TNF	Apoptosis
	TIC10 (ONC-201) 是一种有口服活性的，可透过血脑屏障的，肿瘤坏死因子相关的凋亡诱导配体 TRAIL 诱导剂。它通过抑制 Akt 和 ERK，从而激活 Foxo3a 并显著诱导细胞表面 TRAIL。
T4423	LY 303511 hydrochloride LY303511 hydrochloride	Potassium Channel; TNF; mTOR	Apoptosis; Membrane transporter/Ion channel; PI3K/Akt/mTOR signaling
	LY 303511 hydrochloride 是LY294002 的一种结构类似物。LY 303511 hydrochloride 可增强 SHEP-1 神经母细胞瘤细胞的TRAIL 敏感性，还可逆地阻断 MIN6 胰岛瘤细胞中的K+电流。
T22051	BU 224 hydrochloride	Imidazoline Receptor	Neuroscience
	BU 224 hydrochloride 是一种选择性的咪唑啉 I(2) 结合位点配体，具有镇痛和抗抑郁样活性。
T4403	AX-024 hydrochloride AX-024 HCl	IL Receptor; TNF; COX; IFNAR; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	AX-024 hydrochloride (AX-024 HCl) 是一种细胞因子释放抑制剂，可强烈抑制 IL-6、TNFα、IFN-γ、IL-10 和 IL-17A 的产生。它是口服可利用的 TCR-Nck 相互作用抑制剂，可选择性地抑制 TCR 触发的 T 细胞活化。它通过靶向 SH3结构域调节细胞信号传导，具有低毒、高效和高选择性的特点。
T21445	Naphazoline AK-Con,Naphcon-a,Clear Eyes,All Clear,萘甲唑林	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naphazoline (Naphcon-a) 是一种具有显着 α 肾上腺素能活性的拟交感神经化合物。萘甲唑啉可用作血管收缩剂，当应用于粘膜时可快速减少肿胀。
T0446	Naphazoline hydrochloride 盐酸萘甲唑啉,Albalon,Rhinantin,Naphazoline HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naphazoline hydrochloride (Naphazoline HCl) 是一种咪唑啉衍生物，是一种眼血管收缩剂。
T1813	VGX-1027 VGX1027,VGX 1027,GIT 27	IL Receptor; TNF; Interleukin	Apoptosis; Immunology/Inflammation
	VGX-1027 (GIT 27) 是一种口服有效的异恶唑化合物，靶向巨噬细胞，减少促炎性介质 TNF-α、IL-1β和 IL-10 的产生，具有免疫调节特性。它通过限制细胞因子介导的免疫炎症而具有抗糖尿病作用。
T6204	QNZ CAY10470,EVP4593	TNF; NF-κB	Apoptosis; NF-κB
	QNZ (EVP4593) 是 NF-κB 活化和 TNF-α 产生的一种有效抑制剂。 QNZ 对 NF-κB 和 TNF-α 的 IC50 分别为 11 nM 和 7 nM。
T7889	C25-140	Others; TNF; E1/E2/E3 Enzyme; NF-κB	Apoptosis; NF-κB; Others; Ubiquitination
	C25-140 是一种具有口服活性和一定选择性的 TRAF6-Ubc13相互作用抑制剂。它直接与 TRAF6 结合，阻断 TRAF6 和 Ubc13 的相互作用，降低 TRAF6 和 NF-κB 的活性，并与自身免疫对抗。
T2923	Apremilast 阿普斯特,CC-10004,阿普司特	Apoptosis; TNF; PDE	Apoptosis; Metabolism
	Apremilast (CC-10004) 是一种口服有效的磷酸二酯酶 4 抑制剂，IC50为 74 nM。它抑制脂多糖释放TNF-α，IC50为 104 nM。
T8845	UTL-5g 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g	TNF	Apoptosis
	UTL-5g (3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-) 是一种抗炎性TNF-α抑制剂，可通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性，具有化学保护和肝脏放射保护作用。
T1083L	Theophylline monohydrate Quibron,茶碱一水合物	HDAC; PDE; Adenosine Receptor	Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Theophylline monohydrate (Quibron) 似乎抑制磷酸二酯酶和前列腺素的产生，调节钙通量和细胞内钙分布，并拮抗腺苷。茶碱是黄嘌呤的天然生物碱衍生物，从植物山茶花和小粒咖啡中分离出来。在生理上，该药剂可放松支气管平滑肌，产生血管舒张（脑血管除外），刺激中枢神经系统，刺激心肌，利尿，增加胃酸分泌；它还可以抑制炎症并改善横膈膜的收缩性。
T4412	Roquinimex Linomide,罗喹美克,LS2616,FCF89,ABR212616	TNF	Apoptosis
	Roquinimex (FCF89) 是一种喹啉衍生物免疫刺激剂，可增加 NK 细胞活性和巨噬细胞的细胞毒性，抑制血管生成并减少 TNF α 的分泌。
T1781	GW9508 GW 9508	GPR; Potassium Channel	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel
	GW 9508 是一种选择性 G 蛋白偶联受体FFA1(GPR40) 和GPR120激动剂。它是一种葡萄糖敏感性胰岛素促分泌剂和 ATP 敏感性钾通道开放剂，具有抗炎和抗动脉粥样硬化活性。
T22698	TLR3-IN-1 CU CPT 4a	TLR	Immunology/Inflammation
	TLR3-IN-1 (CU CPT 4a) 是一种选择性的TLR3信号抑制剂，在 RAW 264.7 细胞中 IC50 为 3.44 μM。它可以抑制 TLR3/dsRNA 复合物介导的下游信号通路，并抑制全细胞中 TNF-α 和 IL-1β 的产生。
T60012	HS-243	IRAK; MAPK; CDK	Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; NF-κB
	HS-243 是 IRAK-4 和 IRAK-1 的抑制剂，IC50 分别为 20 和 24 nM。 HS-243 显示出抗炎和抗癌活性。
T0304	Methylthiouracil 甲基硫脲嘧啶,甲硫氧嘧啶,NSC-193526,NSC-9378,MTU	ERK; Antiviral; TNF; NF-κB; Interleukin	Apoptosis; Immunology/Inflammation; MAPK; NF-κB
	Methylthiouracil (NSC-193526) 是一种抗甲状腺剂。它抑制TNF-α和IL-6的产生以及NF-κB 和ERK1/2的活化。
T2036	6-OAU GTPL5846	GPR	Endocrinology/Hormones; GPCR/G Protein
	6-OAU (GTPL5846) 是 GPR84 的替代激动剂，在 Gqi5 嵌合体存在的情况下，在 HEK293 细胞中激活人 GPR84，在 PI 测定中 EC50 为 105 nM。
T12985L	SPD304	TNF	Apoptosis
	SPD304 是一种选择性 TNF-α 抑制剂，可阻断 TNF 与其受体的相互作用。 SPD304 在体外抑制 TNF 受体 1 与 TNF-α 结合的 IC50 为 22 µM。
T2434	LY 303511	Potassium Channel; TNF; mTOR	Apoptosis; Membrane transporter/Ion channel; PI3K/Akt/mTOR signaling
	LY303511 是 LY294002 的结构类似物，可增强 SHEP-1 神经母细胞瘤细胞的TRAIL 敏感性，还可逆地阻断 MIN6 胰岛瘤细胞中的K+电流，IC50为64.6±9.1 μM。
T6823	E3330	HIF/HIF Prolyl-Hydroxylase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	E3330 是一种口服有效的选择性 AP 内切核酸酶 1 (APE1; REF-1) 抑制剂，可抑制NF-κB DNA 结合活性。它阻断 TNF-α 诱导的肝癌细胞系中 IL-8 的激活，可以抑制癌细胞的生长和迁移，具有抗癌活性。
T38227	Quin C1	Others	Others
	Quin C1 是一种具有选择性和高效性的甲酰肽受体 2 (FPR2/ALX) 激动剂，具有抗炎活性，抑制BALF 中的中性粒细胞和淋巴细胞的产生，减少 TNF-α、IL-1β、KC 和 TGF-β1 的表达。Quin C1 可用于研究肺损伤。
T28958	TG6-129 TG6 129	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	TG6-129 是有效的EP2受体选择性拮抗剂，可降低 butaprost 诱导的 P388D1 巨噬细胞中炎症因子的表达。
T77484	Atibuclimab	TNF	Apoptosis
	Atibuclimab 是一种靶向 CD14 的嵌合单克隆抗体，由小鼠可变区和人类 IgG4 Fc 区构成。Atibuclimab 可用于治疗肌萎缩侧索硬化症。Atibuclimab 可减少 LPS 诱导的病症，并对 LPS 诱导的促炎细胞因子释放有抑制作用，可延迟抗炎细胞因子可溶性 TNF 受体 I 型的释放，
T11886	LTβR-IN-1	Others; NF-κB; LTR	Immunology/Inflammation; NF-κB; Others
	LTβR-IN-1是一种有作用的、具有选择性的淋巴素β受体(LTβR)抑制剂。LTβR-IN-1 对TNF12A 的的 p52 的核易位抑制作用具有选择性，对 TNF-α 受体介导的 p65 的核易位无明显作用，却抑制受 TWEAK 或 Anti-LTβR 刺激的 p52 核易位，IC50为10 μM。LTβR-IN-1通过配体非依赖性方式实现对 NF-kB 信号通路的调节作用。
T13063	T6167923	MyD88	Immunology/Inflammation
	T6167923是一种有效的、选择性的MyD88依赖性信号通路抑制剂。T6167923 与 MyD88 的 Toll/IL1 受体 (TIR) 结构域结合良好，破坏 MyD88 的同二聚体形成。T6167923 抑制 NF-κB 驱动的葡萄球菌肠毒素AP (SEAP) 活性，并且改善抗炎活性，对 IFN-γ，IL-1β，IL-6 和 TNF-α 的 IC50分别为 2.7 μM，2.9 μM，2.66 μM 和 2.66 μM。
T12781	RV01	Others	Others
	RV01 是一种新型的白藜芦醇喹啉取代类似物，可抑制 DNA 损伤，降低乙醇诱导的乙醛脱氢酶 (ALDH2) 的 mRNA 表达，具有清除羟自由基的活性。RV01 降低 iNOS 的表达，具有抗神经炎症作用。RV01降低肿瘤坏死因子-a (TNF-a)和白细胞介素-6 (IL-6) mRNA 水平和分泌，抑制lps 诱导的ROS 生成和烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶活化，降低toll 样受体4 (TLR4)的蛋白表达，抑制lps 诱导的丝裂原活化蛋白激酶(MAPK)和核转录因子-кB (NF-кB)信号通路的激活。
T7672	MD2-TLR4-IN-1	TLR	Immunology/Inflammation
	MD2-TLR4-IN-1 是一种骨髓分化蛋白 2/toll 样受体 4 (MD2-TLR4) 复合物抑制剂，能够抑制巨噬细胞 LPS 诱导的 TNF-α 和 IL-6 的表达，IC50值分别为 0.89 和 0.53 μM。
T9948	NecroX-7 LC-280126,LC28-0126,LC28 0126	NADPH-oxidase	Immunology/Inflammation
	NecroX-7 (LC-280126) 是一种有效的自由基清除剂和 HMGB1(高迁移率族蛋白 1) 抑制剂。NecroX-7 可以作为对乙酰氨基酚毒性的解毒剂。NecroX-7 通过抑制缺血/再灌注损伤中 HMGB1 的释放发挥保护作用。NecroX-7 抑制 HMGB1 诱导的 TNF 和 IL-6的释放，以及TLR-4和晚期糖基化终产物受体的表达，用于移植物抗宿主病 (GVHD) 研究。
T1562	Rebamipide Proamipide,OPC12759,瑞巴派特	Free radical scavengers; COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience; oxidation-reduction
	Rebamipide (OPC12759) 是一种粘膜保护剂，可诱导COX-2表达，增加PGE2水平，并以 COX-2 依赖性方式增强胃粘膜防御。
T13375	YQ128	IL Receptor; NOD-like Receptor (NLR); NOD; Interleukin	Immunology/Inflammation; NF-κB
	YQ128 是选择性 NLRP3 炎性体抑制剂(IC50:0.30 µM)。它能显著的、选择性抑制 IL-1β的产生，但不影响 TNF-α 的产生。它能够透过血脑屏障到达中枢神经系统。它具有抗炎作用。
T36127	TNF-α Antagonist
	TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destr...
T38339	R-8507	Others	Others
	R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells.{\|Gururaja2007\|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.
T29590	Acetoxycycloheximide	Others	Others
	Acetoxycycloheximide induces cell surface TNF receptor 1. It also rapidly induces apoptosis mediated by the release of cytochrome c via activation of c-Jun N-terminal kinase.
T76825	Ruplizumab
	Ruplizumab (BG 9588) 是一种人源化单克隆抗 CD40L(TNF Receptor) IgG1κ 抗体。Ruplizumab 具有用于系统性红斑狼疮疾病研究的潜力。

化合物

Cat.No: T4637

Synonym: TNF-α Antagonist III

Target: TNF

Cat.No: T4319

Synonym: (Z)-Hispidol

Target: TNF

(Rac)-Benpyrine

Cat.No: T8692

Target: TNF

Cat.No: T14848

Target: Others, TNF

Cat.No: T9921

Target: TNF

Cat.No: T11096

Target: NF-κB

Cat.No: T2065

Synonym: DR5 Activator

Target: Apoptosis, TNF

Cat.No: TQ0181

Synonym: CLI-095,TAK-242,瑞沙托维

Target: TNF, TLR, Autophagy, Interleukin

Cat.No: T13951

Target: TNF

Cat.No: T12997

Target: p38 MAPK, TNF

Cat.No: T40423

Target: Others

Cat.No: T3561

Synonym: CPI-1189,REN-1189,CPI 1189

Target: TNF

N-Formyl-Met-Leu-Phe

Cat.No: T7091

Synonym: fMLP,N-Formyl-MLF

Target: TNF

Cat.No: T12493

Target: Others, RIP kinase

Cat.No: T8727

Target: TLR, Antibacterial

Cat.No: T7001

Synonym: ONC-201

Target: Apoptosis, TNF

LY 303511 hydrochloride

Cat.No: T4423

Synonym: LY303511 hydrochloride

Target: Potassium Channel, TNF, mTOR

BU 224 hydrochloride

Cat.No: T22051

Target: Imidazoline Receptor

AX-024 hydrochloride

Cat.No: T4403

Synonym: AX-024 HCl

Target: IL Receptor, TNF, COX, IFNAR, Interleukin

Cat.No: T21445

Synonym: AK-Con,Naphcon-a,Clear Eyes,All Clear,萘甲唑林

Target: Adrenergic Receptor

Naphazoline hydrochloride

Cat.No: T0446

Synonym: 盐酸萘甲唑啉,Albalon,Rhinantin,Naphazoline HCl

Target: Adrenergic Receptor

Cat.No: T1813

Synonym: VGX1027,VGX 1027,GIT 27

Target: IL Receptor, TNF, Interleukin

Cat.No: T6204

Synonym: CAY10470,EVP4593

Target: TNF, NF-κB

Cat.No: T7889

Target: Others, TNF, E1/E2/E3 Enzyme, NF-κB

Cat.No: T2923

Synonym: 阿普斯特,CC-10004,阿普司特

Target: Apoptosis, TNF, PDE

Cat.No: T8845

Synonym: 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g

Target: TNF

Theophylline monohydrate

Cat.No: T1083L

Synonym: Quibron,茶碱一水合物

Target: HDAC, PDE, Adenosine Receptor

Cat.No: T4412

Synonym: Linomide,罗喹美克,LS2616,FCF89,ABR212616

Target: TNF

Cat.No: T1781

Synonym: GW 9508

Target: GPR, Potassium Channel

Cat.No: T22698

Synonym: CU CPT 4a

Target: TLR

Cat.No: T60012

Target: IRAK, MAPK, CDK

Methylthiouracil

Cat.No: T0304

Synonym: 甲基硫脲嘧啶,甲硫氧嘧啶,NSC-193526,NSC-9378,MTU

Target: ERK, Antiviral, TNF, NF-κB, Interleukin

Cat.No: T2036

Synonym: GTPL5846

Target: GPR

Cat.No: T12985L

Target: TNF

Cat.No: T2434

Target: Potassium Channel, TNF, mTOR

Cat.No: T6823

Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis

Cat.No: T38227

Target: Others

Cat.No: T28958

Synonym: TG6 129

Target: Prostaglandin Receptor

Cat.No: T77484

Target: TNF

Cat.No: T11886

Target: Others, NF-κB, LTR

Cat.No: T13063

Target: MyD88

Cat.No: T12781

Target: Others

Cat.No: T7672

Target: TLR

Cat.No: T9948

Synonym: LC-280126,LC28-0126,LC28 0126

Target: NADPH-oxidase

Cat.No: T1562

Synonym: Proamipide,OPC12759,瑞巴派特

Target: Free radical scavengers, COX, Prostaglandin Receptor

Cat.No: T13375

Target: IL Receptor, NOD-like Receptor (NLR), NOD, Interleukin

TNF-α Antagonist

Cat.No: T36127

Cat.No: T38339

Target: Others

Acetoxycycloheximide

Cat.No: T29590

Target: Others

Cat.No: T76825

Cat. No.	Product Name	Target	Signaling Pathways
T6S0630	Hypaconitine	P450; TNF	Apoptosis; Metabolism
	Hypaconitine 是从乌头属种分离的一种高毒性成分，可研究风湿病。
T6S2099	Geraniin	Antioxidant; TNF	Apoptosis; oxidation-reduction
	Geraniin 是一种肿瘤坏死因子α释放抑制剂，其IC50值为 43 μM，具有抗肿瘤、抗炎和抗高血糖活性。
T4S0217	HOMOPLANTAGININ	TNF; NF-κB	Apoptosis; NF-κB
	Homoplantaginin 是来自中药荔枝草的一种类黄酮，具有抗炎和抗氧化活性。
T6S0627	Mesaconitine 新乌碱,新乌头碱；中乌头碱	TNF	Apoptosis
	Mesaconitine 是乌头属植物的一种主要活性成分，通过循环 AMP 和刺激中枢 β-肾上腺素能系统具有镇痛活性，还有抗炎活性。
T2879	Fisetin 漆黄素,非瑟酮	TNF; Sirtuin; PPAR	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Fisetin 是在许多水果和蔬菜中发现的一种天然黄酮醇，有抗氧化、抗癌和神经保护作用。
T6S1597	Mulberroside A 桑皮苷 A,桑皮苷A	TNF; Tyrosinase; Interleukin	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Mulberroside A 是桑中的一种主要活性成分，可降低TNF-α、IL-1β和IL-6的表达，抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化。它抑制蘑菇酪氨酸酶，具有抗炎和抗细胞凋亡作用。
T2893	Muscone 3-Methylcyclopentadecanone,Methylexaltone,麝香酮	MMP; TNF; NF-κB; NOD-like Receptor (NLR); P-gp; Interleukin	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; NF-κB; Proteases/Proteasome
	Muscone (3-Methylcyclopentadecanone) 是中药麝香的一种主要活性单体。它抑制NF-κB 和NLRP3炎性小体的活化，显著降低炎性细胞因子水平，并最终改善心脏功能和存活率。
T4S0227	Sinensetin Pedalitin permethyl ether,甜橙素	TNF; PGE Synthase	Apoptosis; Immunology/Inflammation
	Sinensetin (Pedalitin permethyl ether) 是从水果中发现的一种甲基化黄酮，有很强的抗血管和抗炎症的能力。
T2720	Ginsenoside Rc Panaxoside Rc,人参皂苷Rc,人参皂苷 Rc	Others; TNF; GABA Receptor; Interleukin	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Others
	Ginsenoside Rc (Panaxoside Rc) 是人参中的一种人参皂苷，可抑制 TNF-α 和 IL-1β 的表达。它增强 GABA 受体 A 介导的离子通道电流。
T3893	Forsythoside B 连翘酯苷 B,连翘脂苷B	TNF; NF-κB	Apoptosis; NF-κB
	Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha，IL-6，IκB，调节 NF-κB。它抑制炎症反应，具有抗氧化和神经保护作用。
T15686	L-741626 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole	Dopamine Receptor	GPCR/G Protein; Neuroscience
	L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) 是D2多巴胺受体选择性拮抗剂，对人 D2、D3 和 D4 受体的Ki 分别为 2.4、100 和 220 nM。
T4S1521	1,4-Dicaffeoylquinic acid 1,4-二咖啡酰奎宁酸,洋蓟素	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	1,4-Dicaffeoylquinic acid 是一种苯丙素类物质，从苍耳子中获得，可以减少 LPS 诱导的 TNF-α 的生成，具有抗炎活性。
T7786	Tryptanthrin	DNA gyrase	DNA Damage/DNA Repair
	Tryptanthrin 是一种口服具有活性的细胞内Leukotriene (LT) biosynthesis 抑制剂。它能够降低大鼠胸膜炎模型中的 LTB4 水平，并抑制人全血中Leukotriene 的形成 (IC50= 10 µM)。
T6S2140	β-Anhydroicaritin Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素	MMP; Others; TNF; Interleukin	Apoptosis; Immunology/Inflammation; Others; Proteases/Proteasome
	β-Anhydroicaritin 是从乳香提取的一种天然产物，具有重要的生物学和药理学作用，如抗骨质疏松症，雌激素调节和抗肿瘤特性。它改善牙周组织的降解，抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。它抑制细胞内 Ca2+的升高，并显著降低 iNOS 蛋白的表达。
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
TN6796	2'-FUCOSYLLACTOSE 2'-Fucosyl-D-lactose,2'-岩藻糖基乳糖	Others	Others
	2'-FUCOSYLLACTOSE (2'-Fucosyl-D-lactose) 是一种含岩藻糖的寡糖。
T2794	Astilbin Neoastilbin,Taxifolin 3-O-rhamnoside,Isoastilbin,Taxifolin 3-rhamnoside,落新妇苷,Neoisoastilbin	TNF; NF-κB; Nrf2	Apoptosis; Immunology/Inflammation; NF-κB
	Astilbin (Neoastilbin) 是在圣约翰草和中药草药制剂中发现的一种黄酮类天然产物，抑制TNF-α表达和NF-κB 活化，可增强NRF2活化。
T2758	Madecassic acid 6-Deoxy-L-Galactose,羟基积雪草酸,L-Fucose,Brahmic acid,L-fucopyranose	Others; TNF; COX; NO Synthase; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience; Others
	Madecassic acid (L-fucopyranose) 是分离自积雪草的一种天然产物，抑制iNOS、COX-2、TNF-α、IL-1beta 和IL-6，可通过在 RAW 264.7 巨噬细胞中下调NF-κB 激活而具有抗炎作用。
TN1291	7,3',4'-Tri-O-methylluteolin 5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚	TNF; COX; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是来自草药马鞭草科的一种类黄酮，具有抗炎，解热，镇咳，抗糖尿病、抗癌和抗黑素生成特性。它以浓度依赖方式明显抑制促炎细胞因子，可显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。
T6S1538	Neochlorogenic acid 新绿原酸,trans-5-O-Caffeoylquinic acid,Neochlorogenate,金银花,5-O-Caffeoylquinic acid	TNF; NF-κB; COX; Antibacterial; Interleukin	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) 是在干果和其他植物中发现的一种多酚类天然产物，可抑制iNOS 和COX-2蛋白表达，抑制TNF-α和IL-1β产生，还抑制磷酸化的NF-κB p65和p38 MAPK 活化。
T1125	Shikonin NSC 252844,Isoarnebin 4,(+)-Shikonin,紫草素,Alkanna Red,C.I. 75535,Anchusa acid	TNF; NF-κB; Chloride channel; HIV Protease; PKM	Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Shikonin (Anchusa acid) 属于天然产物，是一种 TMEM16A 氯离子通道抑制剂 (IC50=6.5 μM) 和选择性 PKM2 抑制剂。Shikonin 具有抗肿瘤、抗炎和伤口愈合活性。
T2932	Ginsenoside Rh1 Sanchinoside B2,人参皂苷 Rh1,人参皂苷Rh1,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1	IL Receptor; TNF; Endogenous Metabolite; PPAR; Interleukin	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism
	Ginsenoside Rh1 (Sanchinoside B2) 是人参的一种主要成分，具有抗炎作用，抑制PPAR-γ，TNF-α，IL-6和IL-1β的表达。
TN6694	5,6-Benzoflavone β-Naphthoflavone,beta-NF	Antioxidant	oxidation-reduction
	5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体，可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性，抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴，抑制 LPS 诱导的炎症，抑制TNF-α诱导的ICAM-1和VCAM-1表达，可用于研究神经退行性疾病。
T2768	Saikosaponin A 柴胡皂苷A,柴胡皂苷 A	NF-κB; Antibacterial; Liver X Receptor	Metabolism; Microbiology/Virology; NF-κB
	Saikosaponin A 是银柴胡中的主要活性成分，有抗炎活性，可上调 LXRα的表达。
T4973	Paraxanthine 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE	Endogenous Metabolite	Metabolism
	Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物，能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。
TN2360	Falcarinol Panaxynol,Carotatoxin	Cannabinoid Receptor; HSP	Cytoskeletal Signaling; GPCR/G Protein; Metabolism
	Falcarinol (Panaxynol) 是一种具有口服活性且靶向 Hsp90 的 N 端和 C 端的 Hsp90 抑制剂和共价大麻素 CB1 受体拮抗剂，具有毒性，抑制安非他命对TNF-α刺激的角质形成细胞的作用。Falcarinol 诱导细胞凋亡，在皮肤中诱导促过敏作用。
TN1235	3,4,5-Tricaffeoylquinic acid	TNF; Akt; HIV Protease	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-κB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease.

天然产物

Cat.No: T6S0630

Target: P450, TNF

Cat.No: T6S2099

Target: Antioxidant, TNF

HOMOPLANTAGININ

Cat.No: T4S0217

Target: TNF, NF-κB

Cat.No: T6S0627

Synonym: 新乌碱,新乌头碱；中乌头碱

Target: TNF

Cat.No: T2879

Synonym: 漆黄素,非瑟酮

Target: TNF, Sirtuin, PPAR

Cat.No: T6S1597

Synonym: 桑皮苷 A,桑皮苷A

Target: TNF, Tyrosinase, Interleukin

Cat.No: T2893

Synonym: 3-Methylcyclopentadecanone,Methylexaltone,麝香酮

Target: MMP, TNF, NF-κB, NOD-like Receptor (NLR), P-gp, Interleukin

Cat.No: T4S0227

Synonym: Pedalitin permethyl ether,甜橙素

Target: TNF, PGE Synthase

Cat.No: T2720

Synonym: Panaxoside Rc,人参皂苷Rc,人参皂苷 Rc

Target: Others, TNF, GABA Receptor, Interleukin

Cat.No: T3893

Synonym: 连翘酯苷 B,连翘脂苷B

Target: TNF, NF-κB

Cat.No: T15686

Synonym: 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole

Target: Dopamine Receptor

1,4-Dicaffeoylquinic acid

Cat.No: T4S1521

Synonym: 1,4-二咖啡酰奎宁酸,洋蓟素

Target: HIV Protease

Cat.No: T7786

Target: DNA gyrase

β-Anhydroicaritin

Cat.No: T6S2140

Synonym: Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素

Target: MMP, Others, TNF, Interleukin

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

2'-FUCOSYLLACTOSE

Cat.No: TN6796

Synonym: 2'-Fucosyl-D-lactose,2'-岩藻糖基乳糖

Target: Others

Cat.No: T2794

Synonym: Neoastilbin,Taxifolin 3-O-rhamnoside,Isoastilbin,Taxifolin 3-rhamnoside,落新妇苷,Neoisoastilbin

Target: TNF, NF-κB, Nrf2

Madecassic acid

Cat.No: T2758

Synonym: 6-Deoxy-L-Galactose,羟基积雪草酸,L-Fucose,Brahmic acid,L-fucopyranose

Target: Others, TNF, COX, NO Synthase, Interleukin

7,3',4'-Tri-O-methylluteolin

Cat.No: TN1291

Synonym: 5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚

Target: TNF, COX, Interleukin

Neochlorogenic acid

Cat.No: T6S1538

Synonym: 新绿原酸,trans-5-O-Caffeoylquinic acid,Neochlorogenate,金银花,5-O-Caffeoylquinic acid

Target: TNF, NF-κB, COX, Antibacterial, Interleukin

Cat.No: T1125

Synonym: NSC 252844,Isoarnebin 4,(+)-Shikonin,紫草素,Alkanna Red,C.I. 75535,Anchusa acid

Target: TNF, NF-κB, Chloride channel, HIV Protease, PKM

Ginsenoside Rh1

Cat.No: T2932

Synonym: Sanchinoside B2,人参皂苷 Rh1,人参皂苷Rh1,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1

Target: IL Receptor, TNF, Endogenous Metabolite, PPAR, Interleukin

5,6-Benzoflavone

Cat.No: TN6694

Synonym: β-Naphthoflavone,beta-NF

Target: Antioxidant

Cat.No: T2768

Synonym: 柴胡皂苷A,柴胡皂苷 A

Target: NF-κB, Antibacterial, Liver X Receptor

Cat.No: T4973

Synonym: 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE

Target: Endogenous Metabolite

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

Cat.No: TN2360

Synonym: Panaxynol,Carotatoxin

Target: Cannabinoid Receptor, HSP

3,4,5-Tricaffeoylquinic acid

Cat.No: TN1235

Target: TNF, Akt, HIV Protease

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03203	CD40 Protein, Rat, Recombinant (His) CD40 molecule, TNF receptor superfamily me...	Rat	HEK293 Cells
	CD40 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.6 kDa and the accession number is A0A8I6A2T5.
TMPY-01697	TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) Tnfr-1,TNFR80,TNF-R-II,TNF	Mouse	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is P25119.
TMPY-02535	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc) TNFalpha-R1,TNFAR,TNF-R-I,TNF...	Mouse	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.4 kDa and the accession number is P25118.
TMPY-01166	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His) TNFR80,p75,TNF-R75,TNFR1B,tumor n...	Human	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is P20333-1.
TMPY-01181	CD40 Protein, Human, Recombinant (His) CDW40,CD40 molecule, TNF receptor superfam...	Human	HEK293 Cells
	CD40 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.7 kDa and the accession number is A0A0S2Z3C7.
TMPY-01459	TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) p60,TNFR60,TNFAR,TBP1,CD120a,TNFR...	Human	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.7 kDa and the accession number is P19438-1.
TMPY-05957	CD40 Protein, Mouse, Recombinant (His) Bp50,HIGM1,TRAP,T-BAM,GP39,AI326936,p50,IGM,CD40 molecule, <...	Mouse	HEK293 Cells
	CD40 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.81 kDa and the accession number is P27512-1.
TMPY-05039	LTBR Protein, Human, Recombinant (hFc) TNFR-RP,lymphotoxin β receptor (TNF	Human	HEK293 Cells
	LTBR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.8 kDa and the accession number is P36941-1.
TMPJ-00607	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) Receptor activator of nuclear factor κ-B ligand,Ost...	Mouse	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is BAA97257.1.
TMPJ-00288	TNF RII Protein, Human, Recombinant (mFc) Tumor necrosis factor receptor 2,TNFRSF1B,...	Human	HEK293 Cells
	TNF RII Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60 KDa and the accession number is P20333.
TMPJ-00287	TNF RII Protein, Human, Recombinant (hFc) TNF-R2,Tumor necrosis factor receptor supe...	Human	HEK293 Cells
	TNF RII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-90 KDa and the accession number is P20333.
TMPY-03212	CD40 Protein, Rhesus, Recombinant (His) CD40 molecule, TNF receptor superfamily me...	Rhesus	HEK293 Cells
	CD40 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.7 kDa and the accession number is F6SNI1.
TMPY-03907	CD40 Protein, Canine, Recombinant (hFc) CD40 molecule, TNF receptor superfamily me...	Canine	HEK293 Cells
	CD40 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.1 kDa and the accession number is Q7YRL5.
TMPY-03944	CD40 Protein, Canine, Recombinant CD40 molecule, TNF receptor superfamily me...	Canine	HEK293 Cells
	CD40 Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 19.9 kDa and the accession number is Q7YRL5.
TMPY-03083	CD40 Protein, Rat, Recombinant (hFc) CD40 molecule, TNF receptor superfamily me...	Rat	HEK293 Cells
	CD40 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is Q4QQW2.
TMPY-03211	CD40 Protein, Rhesus, Recombinant (hFc) CD40 molecule, TNF receptor superfamily me...	Rhesus	HEK293 Cells
	CD40 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is F6SNI1.
TMPY-04089	CD40 Protein, Canine, Recombinant (His) CD40 molecule, TNF receptor superfamily me...	Canine	HEK293 Cells
	CD40 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and the accession number is Q7YRL5.
TMPY-01696	TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc) TNF-αR2,TNF-R-II,Tnfr2,TNF	Mouse	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.3 kDa and the accession number is P25119.
TMPY-01639	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His) TNFalpha-R1,TNFRp55,CD120a,TNF-al...	Mouse	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.8 kDa and the accession number is P25118.
TMPY-05359	CD40 Protein, Human, Recombinant (mFc) Bp50,TNFRSF5,CDW40,p50,CD40 molecule, TNF ...	Human	HEK293 Cells
	CD40 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45.5 kDa and the accession number is NP_001309350.1.
TMPY-06600	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & Avi), Biotinylated TNFR1B,TNF-R75,TBPII,p75,TNFR80,p...	Human	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 28.39 kDa and the accession number is NP_001057.1.
TMPY-00482	CD40 Protein, Human, Recombinant (hFc) CDW40,TNFRSF5,CD40 molecule, TNF recep...	Human	HEK293 Cells
	CD40 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is A0A0S2Z3C7.
TMPJ-00168	HVEM Protein, Mouse, Recombinant (hFc) Tnfrsf14,Herpesvirus entry mediator,ATAR,Tumor necr...	Mouse	HEK293 Cells
	Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in ...
TMPY-05614	CD40 Protein, Human, Recombinant (His & Avi), Biotinylated Bp50,p50,CDW40,CD40 molecule, TNF receptor...	Human	HEK293 Cells
	CD40 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 22.4 kDa and the accession number is A0A0S2Z3C7.
TMPY-05814	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His), Biotinylated p75,TBPII,TNF-R-II,CD120b,p75TNFR,TNF<...	Human	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession number is P20333-1.
TMPH-02209	TRAF5 Protein, Human, Recombinant (His & SUMO) TRAF5,RING finger protein 84,TNF receptor-...	Human	E. coli
	Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
TMPY-00934	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & hFc) TNF-R75,TBPII,TNF-R-II,TNFR1B,	Human	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 53 kDa and the accession number is P20333-1.
TMPY-05599	CD40 Protein, Human, Recombinant (hFc & Avi), Biotinylated TNFRSF5,Bp50,CD40 molecule, TNF recept...	Human	HEK293 Cells
	CD40 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 47.7 kDa and the accession number is A0A0S2Z3C7.
TMPY-03881	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (aa 1-268, M196A, His) TNFR80,p75TNFR,TNF-R-II,CD120b,	Human	HEK293 Cells
	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (aa 1-268, M196A, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.7 kDa and the accession number is P20333-2.
TMPY-05475	TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc) MS5,p55-R,p60,TNFR1-d2,TNFR55,TNF...	Human	HEK293 Cells
	TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48 kDa and the accession number is P19438-1.
TMPJ-00655	TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His） TRAIL-R1,TNFRSF10A,cytotoxic TRAIL receptor	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF...
TMPJ-00275	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated DR5,Tumor Necrosis Factor Receptor Superfamily Memb...	Human	HEK293 Cells
	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 18-25 KDa and the accession number is O14763.
TMPJ-00430	TRAIL R2/DR5/TNFRSF10B Protein, Cynomolgus, Recombinant (His) Death Receptor 5,TRAILR2,CD262,DR5,TNFRSF1...	Cynomolgus	HEK293 Cells
	TRAIL R2/DR5/TNFRSF10B Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 22-30 KDa and the accession number is A0A2K5TXK0.
TMPJ-00276	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His) DR5,TRAILR2,TRICK2,TNFRSF10B,KILLER,TNF-Re...	Human	HEK293 Cells
	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His) is expressed in HEK293 mammalian cells with C-Fc-6xHis tag. The predicted molecular weight is 49 KDa and the accession number is O14763.
TMPJ-00418	TRAIL R3/TNFRSF10C Protein, Human, Recombinant (hFc & His) Decoy Receptor 1,Antagonist Decoy Receptor...	Human	HEK293 Cells
	Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
TMPY-05425	CD40 Protein, Mouse, Recombinant (hFc) IGM,AI326936,TRAP,T-BAM,p50,IMD3,Tnfrsf5,HIGM1,GP39...	Mouse	HEK293 Cells
	CD40 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.4 kDa and the accession number is P27512-1.
TMPJ-00274	LTBR Protein, Human, Recombinant (His) TNFCR,Tumor Necrosis Factor Receptor Super...	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 3, also known as Lymphotoxin-beta receptor,Tumor necrosis factor C receptor,Tumor necrosis factor receptor 2-related protein,Tumor necrosis factor receptor type III,LTBR,TNFCR, TNFR3 and TNFRSF3, is a member of the tumor necrosis factor (TNF) family of receptors. LTBR is a single-pass type I membrane protein and contains four TNFR-Cys repeats. It is expressed on the surface of most cell types, but not on T and B lymphocytes. LTBR and its ligand p...
TMPH-02208	TRAF3 Protein, Human, Recombinant LMP1-associated protein 1,TNF receptor-ass...	Human	E. coli
	Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein liga...
TMPY-06024	CD40 Protein, Mouse, Recombinant (His & Avi), Biotinylated T-BAM,CD40 molecule, TNF receptor superfam...	Mouse	HEK293 Cells
	CD40 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 22.5 kDa and the accession number is P27512-1.
TMPY-04994	CD40 Protein, Mouse, Recombinant (rFc) HIGM1,IGM,IMD3,p50,GP39,T-BAM,Bp50,Tnfrsf5,TRAP,CD4...	Mouse	HEK293 Cells
	CD40 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 45.4 kDa and the accession number is P27512-1.
TMPH-02207	TRAF3 Protein, Human, Recombinant (His) TRAF3,RING-type E3 ubiquitin transferase TRAF3,TNF ...	Human	E. coli
	TRAF3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 68.6 kDa and the accession number is Q13114.
TMPJ-00546	EFNA1 Protein, Human, Recombinant (hFc) TNFAIP4,LERK1,Tumor Necrosis Factor α-Induced Prote...	Human	HEK293 Cells
	Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the...
TMPH-02960	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His & SUMO) Tnfsf11,Receptor activator of nuclear fact...	Mouse	E. coli
	TNFSF11 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.9 kDa and the accession number is O35235.
TMPH-02210	TRAF6 Protein, Human, Recombinant (His & SUMO) RING finger protein 85,E3 ubiquitin-protein ligase TRAF6,RIN...	Human	E. coli
	TRAF6 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 75.6 kDa and the accession number is Q9Y4K3.
TMPH-02264	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His) Tumor necrosis factor ligand superfamily member 11,Osteoprot...	Human	HEK293 Cells
	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multipl...
TMPJ-01472	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His) Osteoclast differentiation factor,Receptor activato...	Mouse	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 23-29 KDa and the accession number is O35235-1.
TMPJ-00779	TNF alpha Protein, Rabbit, Recombinant TNF-a,Tumor Necrosis Factor,TNF-α,TNF<...	Rabbit	E. coli
	Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor type 2,p75R). TNFα is a pleiotropic cytokine that is capable to promote inflammation, to induce apoptotic cell death, and to inhibit tumorigenesis and viral replication. TNFα is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other ...
TMPJ-00662	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) Receptor activator of nuclear factor kappa-B ligand...	Human	E. coli
	CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitog...
TMPJ-00994	LTBR Protein, Mouse, Recombinant (hFc) Tnfcr,Lymphotoxin-beta receptor,Tumor necr...	Mouse	HEK293 Cells
	It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs...
TMPK-01382	TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His) p75TNFR,p75TBPII,CD120b,TNF-R75,TNF	Cynomolgus	HEK293 Cells
	Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects o...
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重组蛋白

CD40 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03203

Species: Rat

Expression System: HEK293 Cells

TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01697

Species: Mouse

Expression System: HEK293 Cells

TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02535

Species: Mouse

Expression System: HEK293 Cells

TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His)

Cat.No: TMPY-01166

Species: Human

Expression System: HEK293 Cells

CD40 Protein, Human, Recombinant (His)

Cat.No: TMPY-01181

Species: Human

Expression System: HEK293 Cells

TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His)

Cat.No: TMPY-01459

Species: Human

Expression System: HEK293 Cells

CD40 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-05957

Species: Mouse

Expression System: HEK293 Cells

LTBR Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05039

Species: Human

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00607

Species: Mouse

Expression System: HEK293 Cells

TNF RII Protein, Human, Recombinant (mFc)

Cat.No: TMPJ-00288

Species: Human

Expression System: HEK293 Cells

TNF RII Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00287

Species: Human

Expression System: HEK293 Cells

CD40 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-03212

Species: Rhesus

Expression System: HEK293 Cells

CD40 Protein, Canine, Recombinant (hFc)

Cat.No: TMPY-03907

Species: Canine

Expression System: HEK293 Cells

CD40 Protein, Canine, Recombinant

Cat.No: TMPY-03944

Species: Canine

Expression System: HEK293 Cells

CD40 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03083

Species: Rat

Expression System: HEK293 Cells

CD40 Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-03211

Species: Rhesus

Expression System: HEK293 Cells

CD40 Protein, Canine, Recombinant (His)

Cat.No: TMPY-04089

Species: Canine

Expression System: HEK293 Cells

TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01696

Species: Mouse

Expression System: HEK293 Cells

TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01639

Species: Mouse

Expression System: HEK293 Cells

CD40 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05359

Species: Human

Expression System: HEK293 Cells

TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06600

Species: Human

Expression System: HEK293 Cells

CD40 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00482

Species: Human

Expression System: HEK293 Cells

HVEM Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00168

Species: Mouse

Expression System: HEK293 Cells

CD40 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05614

Species: Human

Expression System: HEK293 Cells

TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05814

Species: Human

Expression System: HEK293 Cells

TRAF5 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02209

Species: Human

Expression System: E. coli

TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00934

Species: Human

Expression System: HEK293 Cells

CD40 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-05599

Species: Human

Expression System: HEK293 Cells

TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (aa 1-268, M196A, His)

Cat.No: TMPY-03881

Species: Human

Expression System: HEK293 Cells

TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05475

Species: Human

Expression System: HEK293 Cells

TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His）

Cat.No: TMPJ-00655

Species: Human

Expression System: HEK293 Cells

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00275

Species: Human

Expression System: HEK293 Cells

TRAIL R2/DR5/TNFRSF10B Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-00430

Species: Cynomolgus

Expression System: HEK293 Cells

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00276

Species: Human

Expression System: HEK293 Cells

TRAIL R3/TNFRSF10C Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00418

Species: Human

Expression System: HEK293 Cells

CD40 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-05425

Species: Mouse

Expression System: HEK293 Cells

LTBR Protein, Human, Recombinant (His)

Cat.No: TMPJ-00274

Species: Human

Expression System: HEK293 Cells

TRAF3 Protein, Human, Recombinant

Cat.No: TMPH-02208

Species: Human

Expression System: E. coli

CD40 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06024

Species: Mouse

Expression System: HEK293 Cells

CD40 Protein, Mouse, Recombinant (rFc)

Cat.No: TMPY-04994

Species: Mouse

Expression System: HEK293 Cells

TRAF3 Protein, Human, Recombinant (His)

Cat.No: TMPH-02207

Species: Human

Expression System: E. coli

EFNA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00546

Species: Human

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02960

Species: Mouse

Expression System: E. coli

TRAF6 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02210

Species: Human

Expression System: E. coli

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His)

Cat.No: TMPH-02264

Species: Human

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)

Cat.No: TMPJ-01472

Species: Mouse

Expression System: HEK293 Cells

TNF alpha Protein, Rabbit, Recombinant

Cat.No: TMPJ-00779

Species: Rabbit

Expression System: E. coli

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)

Cat.No: TMPJ-00662

Species: Human

Expression System: E. coli

LTBR Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00994

Species: Mouse

Expression System: HEK293 Cells

TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01382

Species: Cynomolgus

Expression System: HEK293 Cells

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Cat. No.	Product Name	Target	Signaling Pathways
T71328	Theobromine-d6
	Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium....
T71303	Flufenamic Acid-d4
	Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear...

同位素标记化合物

Cat.No: T71328

Flufenamic Acid-d4

Cat.No: T71303

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