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Search Results for " tace "

Targets Recommended: Estrogen Receptor/ERR Estrogen/progestogen Receptor COX

31

抑制剂 & 化合物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2569	Chlorotrianisene tris(p-methoxyphenyl)chloroethylene,氯丁烯二烯,CTA,tri-p-anisylchloroethylene,氯烯雌醚,TACE	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
	Chlorotrianisene (tri-p-anisylchloroethylene) 是长效、可口服、亲脂性高的合成三苯乙烯 (TPE) 衍生物和选择性雌激素受体调节剂，有雌激素活性，也有抗雌激素活性。它还有效抑制COX-1并抑制全血中的血小板聚集。
T8961	GW280264X Carbamic acid	MMP	Proteases/Proteasome
	GW280264X (Carbamic acid) 是一种 ADAM10/TACE (ADAM17)金属蛋白酶抑制剂。它有效阻断 TACE (ADAM17)和 ADAM10的 IC50分别为 8.0 nM 和 11.5 nM。其中ADAM10/17 能够调节胶质母细胞瘤起始细胞的免疫原性。
T1888	Tacedinaline Acetyldinaline,N-acetyldinaline,PD-123654,CI994,Goe-5549	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Tacedinaline (CI994) 是一种组蛋白脱乙酰酶抑制剂，抑制重组 HDAC 1, 2 和 3 的IC50值分别为 0.9，0.9，1.2 μM。
TP1413L	Crustacean Cardioactive Peptide Acetate CCAP acetate
	Crustacean Cardioactive Peptide Acetate (CCAP acetate) 是是节肢动物中最保守和普遍存在的神经肽，在昆虫中由腹侧神经索中的保守神经元网络产生。Crustacean Cardioactive Peptide Acetate 是一种环酰胺化九肽激素，常见于昆虫，甲壳类动物和其他节肢动物中。
T0914	Metacetamol 酰胺苯酚,3-Acetamidophenol	Others	Others
	Metacetamol (3-Acetamidophenol) 是对乙酰氨基酚的衍生物，为其无毒区域异构体，是一种非处方镇痛剂和解热剂，也可用作有机合成中间体。
T10218	Abatacept CTLA4lg	Others	Others
	Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extracellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains). It is a selective T-cell co-stimulation modulator and a protein drug for au
TP1413	Crustacean Cardioactive Peptide (CCAP) Crustacean Cardioactive Peptide CCAP,甲壳类心脏活性肽
	Crustacean cardioactive peptide (CCAP) is a highly conserved, amidated cyclic nonapeptide with the primary structure PFCNAFTGC-NH2 (ProPheCysAsnAlaPheTyrGlyCys-NH2) and a disulfide bridge between Cys3 and Cys9. It is found in crustaceans and insects where
T64239	Belatacept	Others	Others
	Belatacept (BMS 224818) 是一种选择性的 T 细胞共刺激 (T-cell costimulation) 阻滞剂。Belatacept 能够结合 CD 80/86 配体，从而对 CD-28 介导的 T 细胞共刺激表现出抑制作用。Belatacept 能够用于研究器官移植免疫抑制。
T82666	Crustacean cardioactive peptide CCAP
	CCAP（Crustacean cardioactive peptide）为一种具有调节昆虫心脏功能的非极性肽，由9个氨基酸组成，最初自tobacco hawkmoth（Manduca sexta）中分离。其结构特征包括第3位与第9位氨基酸的半胱氨酸残基形成的二硫键，以及羧基末端的氨化。
T24705	Ramentaceone NSC-208733,NSC 624625,NSC 208733,NSC208733,NSC-624625	Others	Others
	Ramentaceone is an antineoplastic.
T30531L	BMS-561392 Formic acid BMS-561392 Formic acid(611227-74-8 Free base)	MMP	Proteases/Proteasome
	BMS-561392 Formic acid 是 TACE 的选择性抑制剂，可降低 TNFalpha 水平。
T4122	TAPI-1 trifluoroacetate (163847-77-6(free base))	MMP	Proteases/Proteasome
	TAPI-1 trifluoroacetate 是一种 ADAM17/TACE 抑制剂，可阻断细胞因子受体的脱落。
T4368	Miriplatin 米铂,SM-11355	DNA Alkylator/Crosslinker	DNA Damage/DNA Repair
	Miriplatin (SM-11355) 是一种烷化剂，是一种用于 TACE 的铂络合物，有望用于治疗肝细胞癌。
T27592	IK-862 IK862,IK 862	MMP	Proteases/Proteasome
	IK-862 是一种选择性 TACE 抑制剂，具有潜在的抗炎抗癌活性，可用于研究神经炎。
T63390L	(S,S)-TAPI-1 FA (S,S)-TAPI-1 FA（171235-71-5 Free base）	TNF	Apoptosis
	(S,S)-TAPI-1 FA是 TNF-α加工抑制剂，具有潜在抗炎作用，可阻断 TACE，可抑制 TNF-α 信号传导可用于研究金黄色葡萄球菌关节炎。
T21297	Miriplatin hydrate SM-11355 (hydrate),Miripla,Miriplatin,SM 11355,SM11355,SM-11355,Miriplatin hydrate	DNA Alkylation	DNA Damage/DNA Repair
	Miriplatin hydrate (SM-11355 (hydrate)) (MPT)是一种用于TACE 的新型铂类化合物，在肝细胞癌(HCC)的治疗中显示出良好的前景。米铂是一种亲脂性铂复合物，容易悬浮在碘油中，并在肿瘤组织中逐渐释放活性铂化合物。
T7522	GI254023X GI 254023X	MMP; Immunology/Inflammation related	Immunology/Inflammation; Proteases/Proteasome
	GI254023X 是MMP9和ADAM10抑制剂，它们的IC50s 分别为 2.5 和 5.3 nM。
T28985	TMI-1 WAY-171318	Apoptosis; MMP	Apoptosis; Proteases/Proteasome
	TMI-1 (WAY-171318) 是一种有效的抑制剂，用于抑制去整合素金属酶17 (ADAM17) 和其他基质金属蛋白酶MMPs。TMI-1 能够有效地抑制LPS 诱导的人原代单核细胞和人全血中TNF-α的分泌。TMI-1 在三阴性 (TN) 和过度表达ERBB2的乳腺肿瘤细胞系中选择性地诱导Caspase 依赖的细胞凋亡。
T27507	GW-3333 GW 3333,GW3333	Others	Others
	GW-3333 is an matrix metalloproteinase inhibitor. It is also a tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) inhibitor. The efficacy of GW3333 suggests that dual inhibitors of matrix metalloproteinases and TACE may prove therapeutic as antiar
T69181	BMS-566394	Others	Others
	BMS-566394 is a potent, exceptionally selective inhibitor of TNF-α converting enzyme (TACE).
T70664	TAPI-0	Others	Others
	TAPI-0 is a matrix metalloprotease (MMP) and TACE inhibitor.
TQ0129	TNF Protease Inhibitor 2 TAPI-2	MMP	Proteases/Proteasome
	TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).
T6009	TAPI1 TAPI 1,TAPI,TAPI-1	MMP	Proteases/Proteasome
	TAPI1 (TAPI) 是一种 ADAM17/TACE 抑制剂，可抑制细胞因子受体的脱落。
T14312	Apratastat	MMP; TNF	Apoptosis; Proteases/Proteasome
	Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively[1].
TP2107	TAPI 0
	ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.
T84690	BMS-561392 formate DPC 333 formate	Others	Others
	BMS-561392formate为BMS-561392的甲酸盐形式，属于一种TNFα转换酶(TACE)及ADAM17抑制剂，主要用于炎症性肠病的研究。
T41179	CL 82198 hydrochloride	Others	Others
	CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibitsin vitroinvasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.
T63390	(S,S)-TAPI-1	Others	Others
	(S,S)-TAPI-1 是一种 TAPI-1 的异构体。其中 TAPI-1是金属蛋白酶 (MMP) 抑制剂，也是 TACE(ADAM17) 抑制剂，对多种细胞表面蛋白脱落表现出有效的抑制作用。
TP2108	TAPI 2
	ADAM-17 (TACE) and MMP inhibitor (Ki = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro. Blocks shedding of TNF-α from cell membranes.
T41079	MMP13-IN-2 MMP13-IN-2	Others	Others
	MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.
T37726	MMP-9 Inhibitor I	Others	Others
	MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.

化合物

Chlorotrianisene

Cat.No: T2569

Synonym: tris(p-methoxyphenyl)chloroethylene,氯丁烯二烯,CTA,tri-p-anisylchloroethylene,氯烯雌醚,TACE

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, COX

Cat.No: T8961

Synonym: Carbamic acid

Target: MMP

Cat.No: T1888

Synonym: Acetyldinaline,N-acetyldinaline,PD-123654,CI994,Goe-5549

Target: Apoptosis, HDAC

Crustacean Cardioactive Peptide Acetate

Cat.No: TP1413L

Synonym: CCAP acetate

Cat.No: T0914

Synonym: 酰胺苯酚,3-Acetamidophenol

Target: Others

Cat.No: T10218

Synonym: CTLA4lg

Target: Others

Crustacean Cardioactive Peptide (CCAP)

Cat.No: TP1413

Synonym: Crustacean Cardioactive Peptide CCAP,甲壳类心脏活性肽

Cat.No: T64239

Target: Others

Crustacean cardioactive peptide

Cat.No: T82666

Synonym: CCAP

Cat.No: T24705

Synonym: NSC-208733,NSC 624625,NSC 208733,NSC208733,NSC-624625

Target: Others

BMS-561392 Formic acid

Cat.No: T30531L

Synonym: BMS-561392 Formic acid(611227-74-8 Free base)

Target: MMP

TAPI-1 trifluoroacetate (163847-77-6(free base))

Cat.No: T4122

Target: MMP

Cat.No: T4368

Synonym: 米铂,SM-11355

Target: DNA Alkylator/Crosslinker

Cat.No: T27592

Synonym: IK862,IK 862

Target: MMP

(S,S)-TAPI-1 FA

Cat.No: T63390L

Synonym: (S,S)-TAPI-1 FA（171235-71-5 Free base）

Target: TNF

Miriplatin hydrate

Cat.No: T21297

Synonym: SM-11355 (hydrate),Miripla,Miriplatin,SM 11355,SM11355,SM-11355,Miriplatin hydrate

Target: DNA Alkylation

Cat.No: T7522

Synonym: GI 254023X

Target: MMP, Immunology/Inflammation related

Cat.No: T28985

Synonym: WAY-171318

Target: Apoptosis, MMP

Cat.No: T27507

Synonym: GW 3333,GW3333

Target: Others

Cat.No: T69181

Target: Others

Cat.No: T70664

Target: Others

TNF Protease Inhibitor 2

Cat.No: TQ0129

Synonym: TAPI-2

Target: MMP

Cat.No: T6009

Synonym: TAPI 1,TAPI,TAPI-1

Target: MMP

Cat.No: T14312

Target: MMP, TNF

Cat.No: TP2107

BMS-561392 formate

Cat.No: T84690

Synonym: DPC 333 formate

Target: Others

CL 82198 hydrochloride

Cat.No: T41179

Target: Others

Cat.No: T63390

Target: Others

Cat.No: TP2108

Cat.No: T41079

Synonym: MMP13-IN-2

Target: Others

MMP-9 Inhibitor I

Cat.No: T37726

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03569	Betacellulin Protein, Human, Recombinant (hFc) betacellulin,βcellulin	Human	HEK293 Cells
	Betacellulin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36 kDa and the accession number is P35070.
TMPY-01323	Betacellulin Protein, Mouse, Recombinant (His & hFc) Bcn,betacellulin,βcellulin	Mouse	HEK293 Cells
	Betacellulin Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38 kDa and the accession number is Q05928.
TMPY-06597	Betacellulin Protein, Rhesus, Recombinant (hFc) betacellulin,βcellulin	Rhesus	HEK293 Cells
	Betacellulin Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36 kDa and the accession number is XP_001101880.3.
TMPH-02464	AIIM Protein, Microbacterium testaceum, Recombinant (His & SUMO) AHL-lactonase,N-acyl homoserine lactonase	Microbacterium testaceum	E. coli
	Hydrolyzes short- and long-chain N-acyl homoserine lactones with or without 3-oxo substitution at C3. Has slight activity towards L-homoserine lactone, and no activity towards gamma-butyrolactone. AIIM Protein, Microbacterium testaceum, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.3 kDa and the accession number is C6L862.
TMPK-00870	AREG Protein, Mouse, Recombinant (hFc) AR,MGC13647,CRDGF,AREG,Amphiregulin,SDGF,AREGB	Mouse	HEK293 Cells
	Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor.
TMPJ-00673	CX3CL1/Fractalkine Protein, Mouse, Recombinant (His) CXC3,Cx3c,NTN,Fkn,C3Xkine,C-X3-C motif chemokine 1,Fractalki...	Mouse	HEK293 Cells
	Fractalkine(CX3CL1) is a single-pass type I membrane protein and belongs to the intercrine delta family. It consists of an extracellular NH2-terminal domain, a mucin-like stalk, a transmembrane α helix, and a short cytoplasmic tail. CX3CL1 exists in two forms: as a membrane-anchored or as a shed 80-95K glycoprotein. Soluble CX3CL1 is generated by limited proteolysis on the cell surface, and a disintegrin and metallopeptidase 10 (ADAM10) and ADAM17/tumor necrosis factor-α-converting enzyme (ADAM1...

重组蛋白

Betacellulin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03569

Species: Human

Expression System: HEK293 Cells

Betacellulin Protein, Mouse, Recombinant (His & hFc)

Cat.No: TMPY-01323

Species: Mouse

Expression System: HEK293 Cells

Betacellulin Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-06597

Species: Rhesus

Expression System: HEK293 Cells

AIIM Protein, Microbacterium testaceum, Recombinant (His & SUMO)

Cat.No: TMPH-02464

Species: Microbacterium testaceum

Expression System: E. coli

AREG Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00870

Species: Mouse

Expression System: HEK293 Cells

CX3CL1/Fractalkine Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00673

Species: Mouse

Expression System: HEK293 Cells

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