Cdc7-IN-15

Cdc7-IN-15 (Example 108) 是 cdc7激酶抑制剂，具有用于癌症研究的潜力。

AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) 是一种可渗透细胞的 JNK 抑制剂（对 hJNK1、hJNK2 和 hJNK3 的 IC50 分别为 150、220 和 70 nM）。

Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to be determined. 1.Serhan, C.N., Gotlinger, K., Hong, S., et al.Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienesJ. Immunol.176(3)1848-1859(2006) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Schwab, J.M., Chiang, N., Arita, M., et al.Resolvin E1 and protectin D1 activate inflammation-resolution programmesNature447(7146)869-874(2007)

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

15,16-Epoxy-15-ethoxy-6beta,13-dihydroxylabd-8-en-7-one 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2633，CAS号为 1374328-47-8。

Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

7-Acetoxy-15-methoxy-10-O-methyldihydrobotrydial 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125441，CAS号为 196796-12-0。

Methyl 15-hydroxy-7-oxodehydroabietate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124573。

Selina-4(15),7(11)-dien-8-one 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3467，CAS号为 54707-47-0。

15-Hydroxy-7-oxodehydroabietic acid是一种天然产物，属于松科松属，其产品编号为 TN2638，CAS号为 95416-25-4。15-Hydroxy-7-oxodehydroabietic acid可用作对照参考。