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Search Results for " β-oxidation "

Targets Recommended: PPAR

25

抑制剂 & 化合物

9

天然产物

3

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9808	Tetradecylthioacetic acid	PPAR	DNA Damage/DNA Repair; Metabolism
	Tetradecylthioacetic acid 是一种合成脂肪酸，在 β 位具有硫取代。这种修饰使 TTA 无法进行完全的 β-氧化并增加其生物活性，包括激活过氧化物酶体增殖物激活受体 (PPAR)，优先选择 PPARα。
T4535	Etomoxir sodium salt (R)-(+)-乙莫克舍钠盐,(R)-Etomoxir sodium salt,Na salt,Etomoxir	Apoptosis; Others	Apoptosis; Others
	Etomoxir sodium salt ((R)-Etomoxir sodium salt) 是一种肉碱棕榈酰转移酶 1a (CPT-1a) 抑制剂，可以阻断脂肪酸合成。Etomoxir sodium salt 具有抗肿瘤活性。
T3268	Mildronate Kvaterin,米屈肼,Meldonium,Quaterin	Hydroxylase	Metabolism
	Mildronate (Meldonium) 是心血管保护药，能够竞争性的抑制 BBOX1和 OCTN2。作用于人重组 BBOX 的(IC50:34-62 μM)、人 OCTN2 (EC50:21 μM)。它能够诱导长链脂肪酸代谢从线粒体向过氧化物酶体的重定向。
T85025	tetranor-Prostaglandin E1 Tetranor PGE1,7α,11-Dihydroxy-5-ketotetranorprost-9-enoic Acid,Tetranorprostaglandin E1	Others	Others
	Tetranor-Prostaglandin E1 (tetranor-PGE1), a metabolite of PGE1 and PGE2, undergoes formation through β-oxidation.
T84506	18-carboxy dinor Leukotriene B4 18-carboxy dinor LTB4	Others	Others
	18-Carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) represents a β-oxidation metabolite of Leukotriene B4 (LTB4). Initially, LTB4 is metabolized in the liver to 20-carboxy LTB4, which subsequently undergoes β-oxidation to form 18-carboxy dinor LTB4.
T37405	Octanoyl Coenzyme A (sodium salt)	Others	Others
	Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD). Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase.
T37839	20-hydroxy Prostaglandin E2 20-hydroxy Prostaglandin E2	Others	Others
	20-hydroxy Prostaglandin E2 (20-hydroxy PGE2) is a product of cytochrome P450 metabolism of PGE2 . ω-Oxidation at C-20 followed by β-oxidation and the loss of up to four carbons from the lower side chain is a prominent metabolic pathway for PGE2. 20-hydroxy PGE2 is the putative first intermediate in this chain of chemical transformations.
T64537	Guanosine 5′-diphospho-β-L-fucose sodium salt	Others	Others
	GDP-β-L-fucose is a metabolite in plant and animal. It used for microbe agglutination assay and agglutination inhibition assay. GDP-β-L-fucose is formed by the oxidation-reduction and epimerization of GDP-R-D-mannose in most organisms.
T80658	Quercetin 7-glucuronide Quercetin 7-O-β-glucuronide	Drug Metabolite	Metabolism
	Quercetin 7-glucuronide（Quercetin 7-O-β-glucuronide），是 Quercetin 的一种代谢产物，从马达加斯加的 Uncarina 物种中可被分离提取。该化合物具有抑制 LDL 氧化的活性。
T37772	tetranor-12(R)-HETE	Others	Others
	Metabolism of 12(R)-HETE in corneal tissue produces predominantly the compound resulting from the loss of four carbon atoms through β-oxidation from C-1. This metabolite is 8(R)-hydroxy hexadecatrienoic acid (8(R)-HHxTrE) or 2,3,4,5-tetranor 12(R)-HETE.
T74038	Palmitoyl coenzyme A lithium	Others	Others
	Palmitoyl coenzyme A lithium，一种酰基-CoA 硫酯，通过肉碱穿梭系统转运至线粒体基质，参与β-氧化，亦作为鞘氨醇生物合成底物。
T84475	Δ2-trans-Hexadecenoic Acid	Others	Others
	Cismonoenoic acids form readily from unsaturated fatty acids in animal tissues, with palmitoleic acid (9-cis-hexadecenoic acid) deriving from palmitic acid. An intermediate, 1Δ2-trans-hexadecenoic acid, arises during the β-oxidation of palmitic acid. Furthermore, Δ2-trans-hexadecenoic acid, at a dose of 10 mg/kg, significantly reduces gastric juice secretion in pylorus-ligated rats, indicating potential for gastric ulceration simulation models.
T76207	Glucose dehydrogenase (GDH)
	Glucose dehydrogenase (GDH)是一种氧化还原酶，催化β-D-葡萄糖氧化成β-D-葡糖酸-1,5-内酯，同时将辅助因子NADP+还原至NADPH，或以较小程度还原NAD+至NADH。此酶能接收NAD+和NADP+作为辅助因子，适用于NADH与NADPH的再生。
T84627	11-dehydro-2,3-dinor Thromboxane B2 11-dehydro-2,3-dinor TXB2	Others	Others
	11-Dehydro-2,3-dinor Thromboxane B2 (11-dehydro-2,3-dinor TXB2) is a metabolite derived from the inactive TXA2 metabolite, TXB2. Its formation involves the action of cytosolic aldehyde dehydrogenase (ALDH) and β-oxidation processes. Remarkably, levels of 11-dehydro-2,3-dinor TXB2 have been observed to increase by 5.2-fold in a surgery-induced rat model of tendon overuse, highlighting its potential role in physiological stress responses.
T37932	15-keto Latanoprost	Others	Others
	Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto latanoprost. 15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-k...
T77253	β-Nicotinamide adenine dinucleotide reduced dipotassium	Others	Others
	β-Nicotinamide adenine dinucleotide reduced dipotassium 作为一种口服有效的还原型辅酶，在ADP-核糖基转移酶反应中担任ADP-核糖单元的供体及环状ADP-核糖的前体。该化合物在细胞能量代谢，包含糖酵解、β-氧化及三羧酸(TCA)循环中，发挥重要的再生电子供体角色。
T85123	3-Aminoisobutyric Acid sodium BAIBA,β-Aminoisobutyric Acid	Others	Others
	3-Aminoisobutyric acid, a non-protein amino acid resultant from thymine catabolism, plays a significant role in metabolic activities. At a 5 µM concentration, it triggers browning in primary adipocytes, notably elevating uncoupling protein 1 (UCP-1) and CIDEA expression. Additionally, it boosts PPARα expression in both primary adipocytes and mouse inguinal white adipose tissue (WAT) in vivo, alongside enhancing β-oxidation in hepatocytes. Its plasma levels surge post-exercise in mice, and its ad...
T37407	Arachidonoyl-L-carnitine (chloride) C20:4 Carnitine,Arachidonoyl-L-carnitine (chloride)	Others	Others
	Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism. It does so by accepting acyl groups from fatty acids complexed with coenzyme A, which yields esterified carnitine or acylcarnitines that enable the transport of fatty acyl groups into the inner mitochondrial matrix. β-Oxidation of fatty acids in mitochondria is inhibited by uncoupling conditions, thus changes in circulating levels of various acylcarnitines have been used to identify alte...
T84847	D-Carnitine	Others	Others
	D-Carnitine为L-肉碱的口服有效异构体，是必需营养素，能促进长链脂肪酸转运至线粒体基质内进行β-氧化。此外，D-Carnitine还具备抗寄生虫活性。
T35464	(±)14(15)-EET-SI	Others	Others
	Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. The EETs are released in response to acetylcholine, bradykinin, arachidonic acid, or cyclic stretch. (±)14(15)-EET-SI is the methyl sulfonamide analog of 14(15)-EET. This substitution results in a metabolically more stable compound because it is not sensitive to β-oxidation or membrane esterification. (±)14(15)-EET-SI is equipotent to 14(15)-EET in vascular agonist act...
T84593	2,3-dinor-8-iso Prostaglandin F2α 2,3-dinor-iPF2α-III	Others	Others
	8-isoProstaglandin F2α (8-isoPGF2α; 8-isoprostane) is a byproduct of non-specific lipid peroxidation, resembling prostaglandin in structure. In humans and rats, its metabolite, 12,3-dinor-8-isoPGF2α, is formed following exogenous administration of 8-isoPGF2α, which is converted to 2,3-dinor-8-isoPGF1α and 2,3-dinor-8-isoPGF2α. Additionally, rat hepatocytes can further break down 8-isoPGF2α into a β-oxidation product, 2,3,4,5-tetranor-8-isoPGF2α. The metabolite, 2,3-dinor-8-isoPGF2α, is normally ...
T36166	8-iso-15-keto Prostaglandin F2α 8-iso-15-keto Prostaglandin F2α	Others	Others
	8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-iso PGF2α is infused into rabbits. Early in the in...
T36165	8-iso-13,14-dihydro-15-keto Prostaglandin F2α 8-iso-13,14-dihydro-15-keto Prostaglandin F2α	Others	Others
	8-iso-13,14-dihydro-15-keto Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2α), in rabbits, monkeys and humans. 8-iso PGF2α is a PG-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-isoprostane is infused into ra...
T37631	tetranor-12(S)-HETE	Others	Others
	12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetran...
T83676	Tianeptine Metabolite MC5 sodium
	Tianeptine metabolite MC5是一种来自非典型抗抑郁化合物tianeptine的活性代谢物，通过β-氧化形成。此代谢物在使用表达人类μ-阿片受体（MOR）而非人类δ-阿片受体（DOR；EC50s = 0.454和 >100 µM, 分别）的HEK293T细胞进行的生物发光共振能量转移(BRET)试验中，特异性诱导G蛋白激活。在野生型小鼠上，30 mg/kg剂量的Tianeptine metabolite MC5可减少强迫游泳测试中的静止时间，但在MOR敲除小鼠中则不会，表明其具有MOR依赖的抗抑郁样活性。

化合物

Tetradecylthioacetic acid

Cat.No: T9808

Target: PPAR

Etomoxir sodium salt

Cat.No: T4535

Synonym: (R)-(+)-乙莫克舍钠盐,(R)-Etomoxir sodium salt,Na salt,Etomoxir

Target: Apoptosis, Others

Cat.No: T3268

Synonym: Kvaterin,米屈肼,Meldonium,Quaterin

Target: Hydroxylase

tetranor-Prostaglandin E1

Cat.No: T85025

Synonym: Tetranor PGE1,7α,11-Dihydroxy-5-ketotetranorprost-9-enoic Acid,Tetranorprostaglandin E1

Target: Others

18-carboxy dinor Leukotriene B4

Cat.No: T84506

Synonym: 18-carboxy dinor LTB4

Target: Others

Octanoyl Coenzyme A (sodium salt)

Cat.No: T37405

Target: Others

20-hydroxy Prostaglandin E2

Cat.No: T37839

Synonym: 20-hydroxy Prostaglandin E2

Target: Others

Guanosine 5′-diphospho-β-L-fucose sodium salt

Cat.No: T64537

Target: Others

Quercetin 7-glucuronide

Cat.No: T80658

Synonym: Quercetin 7-O-β-glucuronide

Target: Drug Metabolite

tetranor-12(R)-HETE

Cat.No: T37772

Target: Others

Palmitoyl coenzyme A lithium

Cat.No: T74038

Target: Others

Δ2-trans-Hexadecenoic Acid

Cat.No: T84475

Target: Others

Glucose dehydrogenase (GDH)

Cat.No: T76207

11-dehydro-2,3-dinor Thromboxane B2

Cat.No: T84627

Synonym: 11-dehydro-2,3-dinor TXB2

Target: Others

15-keto Latanoprost

Cat.No: T37932

Target: Others

β-Nicotinamide adenine dinucleotide reduced dipotassium

Cat.No: T77253

Target: Others

3-Aminoisobutyric Acid sodium

Cat.No: T85123

Synonym: BAIBA,β-Aminoisobutyric Acid

Target: Others

Arachidonoyl-L-carnitine (chloride)

Cat.No: T37407

Synonym: C20:4 Carnitine,Arachidonoyl-L-carnitine (chloride)

Target: Others

Cat.No: T84847

Target: Others

(±)14(15)-EET-SI

Cat.No: T35464

Target: Others

2,3-dinor-8-iso Prostaglandin F2α

Cat.No: T84593

Synonym: 2,3-dinor-iPF2α-III

Target: Others

8-iso-15-keto Prostaglandin F2α

Cat.No: T36166

Synonym: 8-iso-15-keto Prostaglandin F2α

Target: Others

8-iso-13,14-dihydro-15-keto Prostaglandin F2α

Cat.No: T36165

Synonym: 8-iso-13,14-dihydro-15-keto Prostaglandin F2α

Target: Others

tetranor-12(S)-HETE

Cat.No: T37631

Target: Others

Tianeptine Metabolite MC5 sodium

Cat.No: T83676

Cat. No.	Product Name	Target	Signaling Pathways
T5283	NADH disodium salt Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠	Others; Endogenous Metabolite	Metabolism; Others
	NADH disodium salt hydrate是氧化还原酶的辅酶。 NADH在分解代谢过程中起到再生电子供体的作用，包括糖酵解，柠檬酸循环和β-氧化。
T2961	Notoginsenoside R1 Sanqi glucoside R1,Sanchinoside R1,三七皂苷R1	Apoptosis; ERK; Beta Amyloid	Apoptosis; MAPK; Neuroscience
	Notoginsenoside R1 (Sanchinoside R1) 属于皂苷类天然产物，是三七的主要活性单体。Notoginsenoside R1 具有心血管保护、神经保护、肝脏保护、抗肿瘤、免疫调节等活性。
T36831	9-Oxononanoic Acid 9-ONA	Phospholipase; CPT	Metabolism
	9-Oxononanoic Acid是一种氧化脂肪酸，由亚油酸自氧化形成，它能提高磷脂酶 A2（PLA2）的活性，并增加离体人体血浆中血栓素 B2 的生成。9-Oxononanoic Acid 能减少肝脏新脂肪酸的合成，并提高大鼠肝脏肉碱棕榈酰转移酶（β-氧化的标志物）的活性。
T17048	Tetradecanoylcarnitine L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine	Endogenous Metabolite	Metabolism
	Tetradecanoylcarnitine (L-Myristoylcarnitine) 是一种酰基肉碱，参与长链脂肪酸的β-氧化,是极长链酰辅酶A脱氢酶缺乏症的一种潜在标记物。
T1609	NAD+ 烟酰胺腺嘌呤二核苷酸,Cozymase,煙酸胺,β-DPN,DPN,β-Nicotinamide Adenine Dinucleotide,β-NAD	NADPH; Endogenous Metabolite	Metabolism
	NAD+ (β-Nicotinamide Adenine Dinucleotide) 是一种转递氢离子的辅酶，参与细胞中的氧化还原反应。NAD+ 参与糖酵解、柠檬酸循环、脂肪酸氧化等。NAD+ 接受来自其他分子的电子形成 NADH，然后又作为还原剂来给电子。
T41139	Echinocystic acid 28-O-β-D-glucoside	Others	Others
	Echinocystic acid 28-O-β-D-glucoside is a metabolite resulting from the microbial oxidation and glucosidation of Echinocystic acid. It exhibits inhibitory activity towards the tissue factor pathway, with an IC50 value measured at 10.61 nM.
TN4918	Roseoside (6S,9R)-roseoside,Roseoside A	Antioxidant	oxidation-reduction
	Roseoside ((6S,9R)-roseoside)）是一种从 Catharanthus roseus 中分离出来的倍半萜类化合物，具有很强的抗氧化和促胰岛素活性，可抑制脂质氧化，增强β细胞系INS-1的胰岛素释放，可用于研究癌症。
T2S1797	Santalol 檀香醇；白檀油萜醇;檀香脑,檀香醇	Antioxidant; Antifungal	Microbiology/Virology; oxidation-reduction
	Santalol 是一种檀香醇的 α 和 β-异构体混合物。其中α-santalol 分离自檀香油中，是一种有前途的抗癌药，能够预防口腔癌、前列腺癌、乳腺癌和皮肤癌。
T37272	9(S),12(S),13(S)-TriHOME	Others	Others
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...

天然产物

NADH disodium salt

Cat.No: T5283

Synonym: Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠

Target: Others, Endogenous Metabolite

Notoginsenoside R1

Cat.No: T2961

Synonym: Sanqi glucoside R1,Sanchinoside R1,三七皂苷R1

Target: Apoptosis, ERK, Beta Amyloid

9-Oxononanoic Acid

Cat.No: T36831

Synonym: 9-ONA

Target: Phospholipase, CPT

Tetradecanoylcarnitine

Cat.No: T17048

Synonym: L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine

Target: Endogenous Metabolite

Cat.No: T1609

Synonym: 烟酰胺腺嘌呤二核苷酸,Cozymase,煙酸胺,β-DPN,DPN,β-Nicotinamide Adenine Dinucleotide,β-NAD

Target: NADPH, Endogenous Metabolite

Echinocystic acid 28-O-β-D-glucoside

Cat.No: T41139

Target: Others

Cat.No: TN4918

Synonym: (6S,9R)-roseoside,Roseoside A

Target: Antioxidant

Cat.No: T2S1797

Synonym: 檀香醇；白檀油萜醇;檀香脑,檀香醇

Target: Antioxidant, Antifungal

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02481	ACOX1 Protein, Human, Recombinant (His) PALMCOX,ACOX,SCOX,acyl-CoA oxidase 1, palmitoyl	Human	Baculovirus Insect Cells
	Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a...
TMPJ-00933	PRDX5 Protein, Human, Recombinant (His) Antioxidant enzyme B166,Alu corepressor 1,Peroxiredoxin-5,PL...	Human	HEK293 Cells
	Peroxisomes are essential organelles that participate in multiple important metabolic processes, including the β-oxidation of fatty acids, plasmalogen synthesis, and the metabolism of reactive oxygen species (ROS). Peroxiredoxins is overexpressed in breast cancer tissues to a great extent suggesting that they has a proliferative effect and may be related to cancer development or progression. Peroxiredoxin 5 (PRDX5) is a thioredoxin peroxidase that belongs to the atypical 2-Cys class of the TSA/a...
TMPY-02519	BLVRB Protein, Human, Recombinant (His) HEL-S-10,biliverdin reductase B,FLR,BVRB,SDR43U1	Human	E. coli
	Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann-fold) and a C-terminal domain that contains a six-stranded β-sheet that is flanked on one face by several α-helices. The C-terminal and N-terminal domains interact extensively, forming the active site cleft at their interface. Biliverdin reductase (BVR) catalyzes the last step i...

重组蛋白

ACOX1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02481

Species: Human

Expression System: Baculovirus Insect Cells

PRDX5 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00933

Species: Human

Expression System: HEK293 Cells

BLVRB Protein, Human, Recombinant (His)

Cat.No: TMPY-02519

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T71981	Gliclazide-d4
	Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin...

同位素标记化合物

Cat.No: T71981

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