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PROTAC SMARCA2/4-degrader-19 (Compound I-412)主要针对SWI/SNF复合体中的催化亚基SMARCA2及SMARCA4,是一种高效的PROTAC降解剂.该化合物在MV411和A549细胞中能够降解SMARCA2,具有DC50值小于100 nM;同样在MV411细胞中也能降解SMARCA4,其DC50同样低于100 nM.
PROTAC SMARCA2/4-degrader-19 (Compound I-412)主要针对SWI/SNF复合体中的催化亚基SMARCA2及SMARCA4,是一种高效的PROTAC降解剂.该化合物在MV411和A549细胞中能够降解SMARCA2,具有DC50值小于100 nM;同样在MV411细胞中也能降解SMARCA4,其DC50同样低于100 nM.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | PROTAC SMARCA2/4-degrader-19 (Compound I-412) is a PROTAC degrader targeting the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It degrades SMARCA2 in MV411 and A549 cell lines with a DC50 of less than 100 nM, and it degrades SMARCA4 in MV411 with a DC50 also under 100 nM. |
分子量 | 928.16 |
分子式 | C50H61N11O5S |
CAS No. | 2568277-57-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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