Name: Tenovin-6
Brand: TargetMol
SKU: T1818
Price: 543 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 543

In stock

2 mg

¥ 789

In stock

5 mg

¥ 1,820

In stock

10 mg

¥ 2,930

In stock

25 mg

¥ 4,870

In stock

50 mg

¥ 6,950

In stock

100 mg

¥ 9,390

In stock

500 mg

¥ 18,800

In stock

1 mL x 10 mM (in DMSO)

¥ 1,930

In stock

产品介绍

生物活性

产品描述	Tenovin-6 is a p53 transcriptional activity agonist.
靶点活性	SIRT2:10 μM, SIRT1:21 μM, SIRT3:67 μM
体内活性	Tenovins are active on mammalian cells at one-digit micromolar concentrations and decrease tumor growth in vivo as single agents. Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice[1].
激酶实验	Assays are carried out using purified components in the Fluor de Lys Fluorescent Assay Systems. Relevant FdL substrates are used at 7 μM and NAD+ at 1 mM. Tenovins are solubilized in DMSO with the final DSMO concentration in the reaction being less than 0.25%. For SirT1 and HDAC8, one unit of enzyme is used per reaction, and for SirT2 and SirT3, five units is used per reaction. Reactions are carried out at 37°C for 1 hr.
细胞实验	The MTS assay is used to evaluate cell viability. UM cells are seeded into each well of 96-well plates (5,000 cells/well) and treated the next day with control or Tenovin-6 in an increasing concentrations from 0 to 20?μM for 68?h, and then MTS is added at 20?μL/well to be read at a wave length of 490?nm, the IC50 is determined by curve fitting of the sigmoidal dose-response curve.
别名	Tenovin 6

化学信息

分子量	454.63
分子式	C₂₅H₃₄N₄O₂S
CAS No.	1011557-82-6
Smiles	CN(C)CCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1
密度	1.171 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 91 mg/mL (200.16 mM), Sonication is recommended.

H2O: 90 mg/mL (197.96 mM), Sonication is recommended.

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1996 mL	10.9980 mL	21.9959 mL	109.9795 mL
5 mM	0.4399 mL	2.1996 mL	4.3992 mL	21.9959 mL
10 mM	0.2200 mL	1.0998 mL	2.1996 mL	10.9980 mL
20 mM	0.1100 mL	0.5499 mL	1.0998 mL	5.4990 mL
50 mM	0.0440 mL	0.2200 mL	0.4399 mL	2.1996 mL
100 mM	0.0220 mL	0.1100 mL	0.2200 mL	1.0998 mL

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH₂O，那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300/ PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

Tenovin-6

Tenovin-6

产品介绍

计算器

体内实验配液计算器

剂量转换

SCI 文献

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