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Search Results for " protein-deacetylating "

Targets Recommended: Mdm2 Dehydrogenase Sirtuin p53 Autophagy

3

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1919	Tenovin-1 Tenovin 1	Mdm2; Dehydrogenase; Sirtuin; p53; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Tenovin-1 抑制 SirT1 和 SirT2 的蛋白质去乙酰化活性，并防止 MDM2 介导的 p53 降解，这涉及泛素化。它具有癌症的研究潜力。
T1818	Tenovin-6 Tenovin 6	Dehydrogenase; Sirtuin; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Tenovin-6 是 Tenovin-1 的类似物，能抑制二氢乳清酸脱氢酶。它也抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性，IC50分别为 21 μM、10 μM 和 67 μM。它是一种 p53转录活性的激活剂。
T8480	Tenovin-6 Hydrochloride	Dehydrogenase; Sirtuin; HDAC; p53; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Tenovin-6 Hydrochloride 是 Tenovin-1 的类似物，能抑制二氢乳清酸脱氢酶。它是一种 p53转录活性的激活剂，抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性，IC50分别为 21 μM、10 μM 和 67 μM。

化合物

Cat.No: T1919

Synonym: Tenovin 1

Target: Mdm2, Dehydrogenase, Sirtuin, p53, Autophagy

Cat.No: T1818

Synonym: Tenovin 6

Target: Dehydrogenase, Sirtuin, Autophagy

Tenovin-6 Hydrochloride

Cat.No: T8480

Target: Dehydrogenase, Sirtuin, HDAC, p53, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01869	SIRT1 Protein, Human, Recombinant (His) SIR2L1,sirtuin 1	Human	E. coli
	SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent protein deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. It deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. SIRT1 also deacetylates TAF1B and there...
TMPJ-01273	ACY3 Protein, Human, Recombinant (His) Acylase III,Aminoacylase-3,ACY3,Hepatitis C virus core-bindi...	Human	E. coli
	Aspartoacylase 3, also known as ACY3, N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming), Acylase III, Aminoacylase-3, Aspartoacylase-2, Aspartoacylase-2, HCV core-binding protein 1 and ASPA2, is a member of the Aspartoacylase subfamily. ACY3 plays an important role in deacetylating mercapturic acids in kidney proximal tubules and acts on N-acetyl-aromatic amino acids.ACY3 is located in the cytoplasm of S2 and S3 proximal tubules and the apical domain of S1 proximal tubules. ACY3 ...

重组蛋白

SIRT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01869

Species: Human

Expression System: E. coli

ACY3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01273

Species: Human

Expression System: E. coli

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