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Search Results for " voltage-dependent "

Targets Recommended: Ferroptosis VDAC

59

抑制剂 & 化合物

5

天然产物

11

重组蛋白

5

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1765	Erastin	Ferroptosis; VDAC	Apoptosis; Membrane transporter/Ion channel
	Erastin 是一种作用于线粒体 VDAC 的铁死亡激活剂，具有 ROS 和铁依赖性。Erastin 具有抗肿瘤活性，选择性作用于 RAS 致癌突变的肿瘤细胞。该产品在溶液中不稳定，建议现配现用。
T3572	NSC 15364 1,3-Bis(4-aminophenyl)urea,NSC15364	Apoptosis; Others; VDAC	Apoptosis; Membrane transporter/Ion channel; Others
	NSC 15364 (1,3-Bis(4-aminophenyl)urea) 是一种 VDAC1寡聚化和细胞凋亡抑制剂。
T18975	DIDS sodium salt 4,4'-二异硫氰酸基-2,2'-二苯乙烯磺酸二钠[蛋白质改性试剂],MDL101114ZA	VDAC; ABC	Membrane transporter/Ion channel
	DIDS sodium salt (MDL101114ZA) 是有效的ABCA1和VDAC1双抑制剂。
T2141	Mecamylamine hydrochloride 盐酸美加明,Inversine,Mevasin	AChR	Neuroscience
	Mecamylamine hydrochloride (Mevasin) 是一种易穿过血脑屏障的烟碱拮抗剂，用作高血压的神经节阻滞剂，具有抗神经疾病作用。
T0825	Ebselen SPI-1005,PZ-51,依布硒,CCG-39161	Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物，是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒，是HIV-1衣壳 CTD 二聚化的抑制剂，具有抗炎、抗癌和抗氧化活性。
T20341	DNDS	CFTR	Membrane transporter/Ion channel
	DNDS 是电压依赖性囊性纤维化跨膜电导调节剂 (CFTR) 的通道阻滞剂。
T11979	McN5691 MCN 5691,RWJ26240	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	McN5691 (RWJ26240) 是一种电压依赖性钙通道 (calcium channel) 阻滞剂，具有抗高血压活性，可用于研究血管平滑肌异常引发的疾病。
T21263	Amlodipine maleate Amlodipine (+-)-form maleate,Amvaz	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Amlodipine maleate (Amvaz) 是一种具有口服活性的二氢吡啶类钙通道阻滞剂，通过阻滞电压依赖性 L 型钙通道，从而抑制钙离子内流。Amlodipine maleate 可用于研究高血压和癌症。
T17227	Vernakalant Hydrochloride RSD1235 hydrochloride	Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Vernakalant Hydrochloride (RSD1235 hydrochloride) 是一种混合电压和频率依赖性的 Na+ 和 K+ 通道阻断剂。Vernakalant 抑制 Kv1.5 channelwt，Kv1.5 channelI508F，Kv1.5 channelT479A，IC50 分别为 13.35±0.93 μM。
T0596	Phenylhydantoin 5-苯基海因,5-Phenylhydantoin	Others	Others
	Phenylhydantoin (5-Phenylhydantoin) 是 Mephenytoin 的代谢物。它已被证明与电压依赖性钠通道 (NVSC) 结合并具有抗癫痫特性。
T30188L	Atagabalin HCl PD-0200390 HCl,Atagabalin HCl(223445-75-8 Free base）	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Atagabalin HCl 是一种新型电压依赖性钙通道（VDCC）α2δ亚基（1 和 2）配体，会影响慢波睡眠,可用于治疗失眠。
T7502L	PF 05089771 PF-05089771,PF05089771	Sodium Channel	Membrane transporter/Ion channel
	PF 05089771是具有口服有效的、选择性的 Nav1.7丙烯酰胺抑制剂。PF-05089771在疼痛和糖尿病神经性疾病的研究中具有价值。
T26778	Besipirdine HP 749 free base,P-867493,P867493,HP 749,HP749,P 867493	Sodium Channel; Adrenergic Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Besipirdine (HP 749 free base)是一种非受体依赖性拟胆碱化合物，具有α-肾上腺素能活性和心血管活性。Besipirdine 抑制电压依赖性钠钾通道，抑制生物胺的摄取。Besipirdine 可减少大鼠的时间表诱导的烦渴，增强中枢神经系统中的胆碱能和肾上腺素能神经传递。
T26778L	Besipirdine hydrochloride HP 749 hydrochloride,Besipirdine hydrochloride（119257-34-0 Free base)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Besipirdine hydrochloride 是一种非受体依赖性拟胆碱化合物，具有α-肾上腺素能活性和心血管活性。Besipirdine hydrochloride 抑制电压依赖性钠钾通道，抑制生物胺的摄取。Besipirdine hydrochloride 可减少大鼠的时间表诱导的烦渴，增强中枢神经系统中的胆碱能和肾上腺素能神经传递。
T13287	VBIT-4	VDAC	Membrane transporter/Ion channel
	VBIT-4 是一种电压依赖性阴离子通道 1 (VDAC1) 寡聚化抑制剂 (Kd=17 μM)。VBIT-4 可以预防线粒体功能障碍和细胞凋亡，并恢复细胞能量和代谢。VBIT-4 可用于治疗神经退行性疾病和心血管疾病。
T0030	Bupivacaine hydrochloride Vivacaine,Bupivacaine HCl,盐酸布比卡因	Sodium Channel	Membrane transporter/Ion channel
	Bupivacaine hydrochloride (Vivacaine) 是NMDA 受体抑制剂，可用于慢性疼痛的研究。它可阻断钠、L-钙和钾通道，还阻断SCN5A 通道，IC50为 69.5 μM。
T68060	Elgodipine	Others	Others
	Elgodipine 显著降低了运动诱导的心绞痛系统的发生率和严重程度，能够通过独立于转录因子c-fos 和c-jun 表达的机制抑制血管平滑肌增殖。 Elgodipine 诱导的抑制是电压依赖性的。Elgodipine 是治疗心绞痛的潜在化合物。
T23274	RuBi-4AP	Others	Others
	voltage-dependent K+ channel blocker
T70199	Enecadin HCl	Others	Others
	Enecadin HCl is a voltage-dependent sodium and calcium channel blocker.
T26092	Risotilide	Others	Others
	Risotilide is a voltage-dependent potassium channel inhibitor. It can prolong cardiac action potentials and refractory periods.
T16447	β-Amino Acid Imagabalin Hydrochloride PD-0332334	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	β-Amino Acid Imagabalin Hydrochloride is the voltage-dependent calcium channel ligand for the α2δ subunit.
T71281	Nerispirdine	Others	Others
	Nerispirdine is a biochemical that inhibits batrachotoxin binding to voltage-dependent sodium channels.
T16487	PF-05241328	Others	Others
	PF-05241328 is an effective and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (IC50: 31 nM).
T36808	UK 59811 hydrochloride	Others	Others
	Blocks CaVAb, a site-directed mutant of bacterial NaVAb with full voltage-dependent Ca2+ channel function (IC50 = 194 nM). Tang et al (2016) Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs. Nature 537 117 PMID:27556947
T19788	Piretanide Eurelix,Tauliz,Arelix	Others	Others
	Piretanide is a time- and voltage-dependent blocker of CFTR Cl(-) currents. Piretanide also acts as a loop diuretic.
T70691	ITP-2	Others	Others
	ITP-2 is a selective activator of hERG channels. ITP-2 causes large depolarizing shifts in the midpoint of voltage-dependent inactivation and hyperpolarizing shifts in the voltage-dependence of activation.
T10209	A-887826	Others	Others
	A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.
T80439	GTx1-15	Sodium Channel	Membrane transporter/Ion channel
	GTx1-15为一种抑制剂胱氨酸结 (ICK) 肽，能有效抑制电压依赖性钙通道 Cav3.1 以及电压依赖性钠通道 Nav1.3 和 Nav1.7。
TP1967	Phrixotoxin 3
	Potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV1.2, NaV1.3 and NaV1.5 respectively). Blocks inward sodium currents in a voltage-dependent manner.
T26564	ADCI SGB-017,SGB017,SGB 017	Others	Others
	ADCI is an inhibitor of voltage-activated sodium channels and N-methyl-D-aspartate (NMDA)-receptor-gated channels. Inhibition of sodium channels by ADCI was voltage dependent. High doses of ADCI increased dopamine metabolism in the prefrontal cortex and/o
TP2118	SNX-482 SNX 482
	Potent and selective, voltage-dependent R-type CaV2.3 calcium channel blocker (IC50 = 30 nM). Antinociceptive; inhibits nociceptive C-fibre and Aδ-fibre-evoked neuronal responses.
T27032	CK59 CK-59,CK 59	Others	Others
	CK59 is a reversible inhibitor of calcium-calmodulin-dependent kinase II (CaMKII). CK59 inhibits multiple voltage-gated calcium channels, including the L-type channel during depolarization in a dose-dependent manner. The IC50 for CK59 was approximately 50
T14150	AKOS-22	Others	Others
	AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 protects against mitochondrial dysfunction[1]. AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis.
T28346	PD-217014 HCl PD 217014,PD217014,PD-217,014,PD-217014	Others	Others
	PD-217014 is a GABA analog. It inhibits (3)H-gabapentin binding to alpha(2)delta subunit of voltage-gated calcium channels in a concentration-dependent manner (K(i) = 18 nmol/l). PD-217014 possesses visceral analgesic activity.
T68125	(Rac)-PD0299685 (Rac)-PF-299685	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	(Rac)-PD0299685 是一种有效的电压依赖性钙通道抑制剂，可用于研究视网膜相关疾病。
T23210	Quinacrine (dihydrochloride hydrate) Quinacrine (hydrochloride hydrate) (83-89-6 free base)	Others	Others
	Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM） and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of prion protein (EC50: 0.3 μM). As an e
T13286	VBIT-3	Others	Others
	VBIT-3 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 31.3 μM). VBIT-3 also is an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases).
T13428	(5R)-BW-4030W92	Sodium Channel	Membrane transporter/Ion channel
	(5R)-BW-4030W92是 R 型的 BW-4030W92 ，是具有活性的对映体。(5R)-BW-4030W92 是一种可口服的非选择性、电压依赖性和使用依赖性的钠离子通道 (sodium channel) 拮抗剂，可用于研究神经系统疾病。
T76392	β-Bag cell peptide
	β-Bag cell peptide是一种提高袋细胞神经元(bag cell neuron)中cAMP水平、并能降低电压依赖性钾电流的神经活性肽。
T80184	GsAF-II	Sodium Channel	Membrane transporter/Ion channel
	GsAF-II，一种肽毒素，能电压依赖性阻断hERG1亚型钾通道，并对Nav1.x亚型钠离子通道展现阻断效应。
T80980	Tityustoxin-Kα TsTx-Kα
	Tityustoxin-Kα (TsTx-Kα) 为钾电压门控通道抑制剂，表现出对培养的海马神经元持续外向电流的剂量依赖性阻断作用。
T28160	Nerispirdine HCl HP-184,HP 184,Nerispirdine hydrochloride,HP184	Others	Others
	Nerispirdine is a acetylcholine release enhancer, sodium channel blocker and K(V) 2.1 channel blocker. Nerispirdine inhibits voltage-dependent Na(+) channel currents recorded from human SH-SY5Y cells with an IC(50) of 11.9 micromol/L when measured from a
T80028	Iberiotoxin TFA	Potassium Channel	Membrane transporter/Ion channel
	Iberiotoxin (TFA) 是选择性高电导率Ca2+-activated K+ channel抑制剂，Kd约1 nM，不干扰其他电压依赖性离子通道。
T23652	AFD-21 AFD21,NS-2 Class 1 antiarrhythmic agent	Others	Others
	AFD-21是一种 I 类抗心律失常药物。它在钠通道失活状态下与钠通道结合，对钠通道具有使用和电压依赖性抑制作用，其解结合率与具有中等动力学的I 类抗心律失常药物相当。
T80434	Heteropodatoxin-2	Potassium Channel	Membrane transporter/Ion channel
	Heteropodatoxin-2为含30个氨基酸的肽，归属于异足毒素类。它能电压依赖性地阻断非洲爪蟾卵母细胞表达的Kv4.2电流，并在正电位较高时显示出较低的阻断效应。
T60306	NMDA receptor antagonist 4	Others	Others
	NMDA receptor antagonist 4 (IIc) 是一个非竞争性、电压依赖的、口服活性的 NMDAR 阻断剂，IC50值为1.93 μM。NMDA receptor antagonist 4 可透过血脑屏障，可用于研究阿兹海默症。
T84382	LY303511 hydrochloride	Others	Others
	LY303511, a structural analog of LY294002, selectively inhibits mTOR-dependent phosphorylation of S6K, unlike its counterpart, which acts as a phosphatidylinositol 3-kinase (PI3K) inhibitor. It effectively reduces cell proliferation in human lung epithelial adenocarcinoma cells by hindering G2/M phase progression and suppressing casein kinase 2 activity. Additionally, LY303511 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in HeLa cells resistant to TRAIL-in...
T63445	Amlodipine mesylate	Others	Others
	Amlodipine mesylate 是口服具有活力的二氢吡啶钙通道（calcium channel）阻滞剂，能够阻断电压依赖性的 L 型钙通道，并抑制钙离子内流，是一种抗心绞痛药。Amlodipine mesylate 能够用于研究高血压和癌症。
T80050	Noxiustoxin	Potassium Channel	Membrane transporter/Ion channel
	Noxiustoxin为墨西哥蝎子Centruroides noxius毒液中的一种毒素，它能够抑制电压依赖性钾通道（Kv1.3，IC50=360 nM）及钙激活钾通道。该毒素在神经炎症疾病中具有重要作用。
T79280	Nav1.3 channel inhibitor 1	Sodium Channel	Membrane transporter/Ion channel
	Nav1.3 channel inhibitor 1 (化合物 15b) 为状态依赖性电压门控钠通道Nav1.3的抑制剂，具有IC50值为20 nM。该化合物能穿透血脑屏障，适用于神经系统疾病研究。

化合物

Cat.No: T1765

Target: Ferroptosis, VDAC

Cat.No: T3572

Synonym: 1,3-Bis(4-aminophenyl)urea,NSC15364

Target: Apoptosis, Others, VDAC

DIDS sodium salt

Cat.No: T18975

Synonym: 4,4'-二异硫氰酸基-2,2'-二苯乙烯磺酸二钠[蛋白质改性试剂],MDL101114ZA

Target: VDAC, ABC

Mecamylamine hydrochloride

Cat.No: T2141

Synonym: 盐酸美加明,Inversine,Mevasin

Target: AChR

Cat.No: T0825

Synonym: SPI-1005,PZ-51,依布硒,CCG-39161

Target: Phosphatase, Virus Protease, Calcium Channel, COX, HIV Protease

Cat.No: T20341

Target: CFTR

Cat.No: T11979

Synonym: MCN 5691,RWJ26240

Target: Calcium Channel

Amlodipine maleate

Cat.No: T21263

Synonym: Amlodipine (+-)-form maleate,Amvaz

Target: Calcium Channel

Vernakalant Hydrochloride

Cat.No: T17227

Synonym: RSD1235 hydrochloride

Target: Potassium Channel, Sodium Channel

Phenylhydantoin

Cat.No: T0596

Synonym: 5-苯基海因,5-Phenylhydantoin

Target: Others

Cat.No: T30188L

Synonym: PD-0200390 HCl,Atagabalin HCl(223445-75-8 Free base）

Target: Calcium Channel

Cat.No: T7502L

Synonym: PF-05089771,PF05089771

Target: Sodium Channel

Cat.No: T26778

Synonym: HP 749 free base,P-867493,P867493,HP 749,HP749,P 867493

Target: Sodium Channel, Adrenergic Receptor

Besipirdine hydrochloride

Cat.No: T26778L

Synonym: HP 749 hydrochloride,Besipirdine hydrochloride（119257-34-0 Free base)

Target: Adrenergic Receptor

Cat.No: T13287

Target: VDAC

Bupivacaine hydrochloride

Cat.No: T0030

Synonym: Vivacaine,Bupivacaine HCl,盐酸布比卡因

Target: Sodium Channel

Cat.No: T68060

Target: Others

Cat.No: T23274

Target: Others

Cat.No: T70199

Target: Others

Cat.No: T26092

Target: Others

β-Amino Acid Imagabalin Hydrochloride

Cat.No: T16447

Synonym: PD-0332334

Target: Calcium Channel

Cat.No: T71281

Target: Others

Cat.No: T16487

Target: Others

UK 59811 hydrochloride

Cat.No: T36808

Target: Others

Cat.No: T19788

Synonym: Eurelix,Tauliz,Arelix

Target: Others

Cat.No: T70691

Target: Others

Cat.No: T10209

Target: Others

Cat.No: T80439

Target: Sodium Channel

Cat.No: TP1967

Cat.No: T26564

Synonym: SGB-017,SGB017,SGB 017

Target: Others

Cat.No: TP2118

Synonym: SNX 482

Cat.No: T27032

Synonym: CK-59,CK 59

Target: Others

Cat.No: T14150

Target: Others

Cat.No: T28346

Synonym: PD 217014,PD217014,PD-217,014,PD-217014

Target: Others

(Rac)-PD0299685

Cat.No: T68125

Synonym: (Rac)-PF-299685

Target: Calcium Channel

Quinacrine (dihydrochloride hydrate)

Cat.No: T23210

Synonym: Quinacrine (hydrochloride hydrate) (83-89-6 free base)

Target: Others

Cat.No: T13286

Target: Others

(5R)-BW-4030W92

Cat.No: T13428

Target: Sodium Channel

β-Bag cell peptide

Cat.No: T76392

Cat.No: T80184

Target: Sodium Channel

Tityustoxin-Kα

Cat.No: T80980

Synonym: TsTx-Kα

Nerispirdine HCl

Cat.No: T28160

Synonym: HP-184,HP 184,Nerispirdine hydrochloride,HP184

Target: Others

Iberiotoxin TFA

Cat.No: T80028

Target: Potassium Channel

Cat.No: T23652

Synonym: AFD21,NS-2 Class 1 antiarrhythmic agent

Target: Others

Heteropodatoxin-2

Cat.No: T80434

Target: Potassium Channel

NMDA receptor antagonist 4

Cat.No: T60306

Target: Others

LY303511 hydrochloride

Cat.No: T84382

Target: Others

Amlodipine mesylate

Cat.No: T63445

Target: Others

Cat.No: T80050

Target: Potassium Channel

Nav1.3 channel inhibitor 1

Cat.No: T79280

Target: Sodium Channel

Cat. No.	Product Name	Target	Signaling Pathways
T3377	L-Phenylalanine L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine	Calcium Channel; Endogenous Metabolite; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	L-Phenylalanine (3-Phenyl-L-alanine) 是分离自大肠杆菌的必需氨基酸，是 NMDARs(KB573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂，用于食品香料和药品的生产中。它是一种电压依赖性 α2δ 亚基 Ca2+通道拮抗剂，Ki 为 980 nM。
TN1121	Evocarpine	Apoptosis; cAMP; Anti-infection; Calcium Channel; Antibacterial	Apoptosis; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Evocarpine 是从 Evodiae fructus 分离得到的一种喹诺酮类生物碱，有抗细菌活性。它可通过电压依赖性钙通道抑制 Ca2+内流。
TN4183	Hardwickiic acid (-)-Hardwikiic acid	Sodium Channel	Membrane transporter/Ion channel
	Hardwickiic acid ((-)-Hardwikiic acid) 是一种从Pulicaria gnaphalodes 中提取的天然化合物，是一种抗伤害性感受作用化合物。Hardwickiic acid 能阻断河豚毒素敏感的电压依赖性钠通道 (sodium channels)。Hardwickiic acid 具有抗炎和杀虫活性。
T74193	(R)-IDHP	Others	Others
	(R)-IDHP为IDHP异构体，属于丹参代谢物。该化合物能通过抑制血管平滑肌细胞电压依赖性钙通道与受体操作钙通道的Ca2+释放和Ca2+内流，发挥血管松弛作用，适用于心脑血管疾病研究。
TN2534	1-Hydroxy-2,3,5-trimethoxyxanthone	IκB/IKK; Calcium Channel; NOS; 5-HT Receptor; COX	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-c...

天然产物

L-Phenylalanine

Cat.No: T3377

Synonym: L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine

Target: Calcium Channel, Endogenous Metabolite, iGluR

Cat.No: TN1121

Target: Apoptosis, cAMP, Anti-infection, Calcium Channel, Antibacterial

Hardwickiic acid

Cat.No: TN4183

Synonym: (-)-Hardwikiic acid

Target: Sodium Channel

Cat.No: T74193

Target: Others

1-Hydroxy-2,3,5-trimethoxyxanthone

Cat.No: TN2534

Target: IκB/IKK, Calcium Channel, NOS, 5-HT Receptor, COX

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02308	CACNA2D1 Protein, Human, Recombinant (His & SUMO) MHS3,Voltage-dependent calcium channel sub...	Human	E. coli
	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
TMPH-00780	CACNA1C Protein, Guinea Pig, Recombinant (His) CACNA1C,CACNL1A1,CACH2,CACN2,Voltage-dependent<...	Guinea pig	E. coli
	Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressur...
TMPJ-01466	Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His) OPG,Tumor Necrosis Factor Receptor Superfamily Member 11B,OC...	Human	HEK293 Cells
	TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNF...
TMPH-02404	LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO) Alpha-insect toxin LqhaIT,Lqh-alpha-IT	Yellow scorpion	E. coli
	Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice. LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.5 kDa and ...
TMPH-02118	SCN1A Protein, Human, Recombinant (His) Sodium channel protein brain I subunit alpha,Sodium channel ...	Human	E. coli
	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neur...
TMPH-03399	VAMP2 Protein, Rat, Recombinant (His) Vesicle-associated membrane protein 2,Vamp2,Synaptobrevin-2	Rat	E. coli
	Involved in the targeting and/or fusion of transport vesicles to their target membrane. Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. VAMP2 Protein, Rat, Recombina...
TMPH-01889	KCNK3 Protein, Human, Recombinant (His & Myc) Potassium channel subfamily K member 3,TWIK-related acid-sen...	Human	E. coli
	pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. KCNK3 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 50.5 kDa and the accession number is O...
TMPJ-00888	ANXA7 Protein, Human, Recombinant Annexin A7,Annexin-7,Synexin,ANXA7,Annexin VII,SNX,ANX7	Human	E. coli
	Annexin A7 (ANXA7) is a member of the annexin family of calcium-dependent phospholipid binding proteins. Annexin A7 has a unique, highly hydrophobic N-terminal domain and a conserved C-terminal region. The C-terminal region is composed of alternating hydrophobic and hydrophilic segments. Annexin A7 is a calcium/phospholipid-binding protein with diverse properties including voltage-sensitive calcium channel activity and promotes membrane fusion and is also involved in exocytosis.
TMPH-01394	GRIN1 Protein, Human, Recombinant (His) N-methyl-D-aspartate receptor subunit NR1,Glutamate [NMDA] r...	Human	E. coli
	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. GRIN1 Protein, Human, Recombinant (His)...
TMPH-01744	NOX1 Protein, Human, Recombinant (His) NADH/NADPH mitogenic oxidase subunit P65-MOX,NADPH oxidase 1...	Human	E. coli
	NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis t...
TMPY-02955	CABP5 Protein, Human, Recombinant (His) calcium binding protein 5,CABP3	Human	E. coli
	CABP3, also known as CABP5, belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of CABP3 gene is retina-specific. The mouse homolog of CABP3 has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of CABP3 gene is unknown. Study of the transcripts and genomic structure r...

重组蛋白

CACNA2D1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02308

Species: Human

Expression System: E. coli

CACNA1C Protein, Guinea Pig, Recombinant (His)

Cat.No: TMPH-00780

Species: Guinea pig

Expression System: E. coli

Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)

Cat.No: TMPJ-01466

Species: Human

Expression System: HEK293 Cells

LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO)

Cat.No: TMPH-02404

Species: Yellow scorpion

Expression System: E. coli

SCN1A Protein, Human, Recombinant (His)

Cat.No: TMPH-02118

Species: Human

Expression System: E. coli

VAMP2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03399

Species: Rat

Expression System: E. coli

KCNK3 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01889

Species: Human

Expression System: E. coli

ANXA7 Protein, Human, Recombinant

Cat.No: TMPJ-00888

Species: Human

Expression System: E. coli

GRIN1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01394

Species: Human

Expression System: E. coli

NOX1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01744

Species: Human

Expression System: E. coli

CABP5 Protein, Human, Recombinant (His)

Cat.No: TMPY-02955

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T40376	L-Phenylalanine-15N L-苯丙氨酸 15N,(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) 是 15N 标记的 L-Phenylalanine。L-Phenylalanine 是从大肠杆菌中分离出来的一种必需氨基酸。 L-Phenylalanine 广泛用于食品香精和药物的生产。
T19591	Triamterene D5 氨苯蝶啶 D5	Others	Others
	Triamterene D5 is a deuterium-labeled Triamterene and can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, used as a mild diuretic.
T68918	Phenytoin-d10
	Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal...
T11240	Ethacrynic acid D5	Others	Others
	Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by...
TMIH-0087	Amlodipine-d4 Maleate (Racemic)
	Amlodipine-d4 Maleate (Racemic) 是 Amlodipine Maleate (Racemic) 的氘代化合物。Amlodipine Maleate (Racemic) 的 CAS 号为 88150-47-4。Amlodipine maleate是一种具有口服活性的二氢吡啶类钙通道阻滞剂，通过阻滞电压依赖性L型钙通道，从而抑制钙离子内流。Amlodipine maleate可用于研究高血压和癌症。

同位素标记化合物

L-Phenylalanine-15N

Cat.No: T40376

Synonym: L-苯丙氨酸 15N,(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N

Target: Calcium Channel

Cat.No: T19591

Synonym: 氨苯蝶啶 D5

Target: Others

Cat.No: T68918

Ethacrynic acid D5

Cat.No: T11240

Target: Others

Amlodipine-d4 Maleate (Racemic)

Cat.No: TMIH-0087

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