首页工具

登录

搜索结果

Search Results for " schizophrenia "

Targets Recommended: Dopamine Receptor 5-HT Receptor

174

抑制剂 & 化合物

3

天然产物

1

化合物库

13

重组蛋白

9

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name
L2610	神经递质受体化合物库		1513 compounds
	1513 种与神经递质受体相关的化合物，用于高通量、高内涵筛选；

化合物库

神经递质受体化合物库

Cat.No: L2610

Compounds: 1513

Cat. No.	Product Name	Target	Signaling Pathways
T14319	Aripiprazole Lauroxil	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Aripiprazole lauroxil 是一种长效注射剂 (LAI) 的抗精神病药物，是阿立哌唑的 N-酰氧基甲基前药形式。它能够被体内酯酶裂解为 N-羟甲基阿立哌唑(月桂酸)，再裂解为阿立哌唑，无毒性。
T8862	ML 254	GluR	Neuroscience
	是一种化学合成中的砌块
T21629	Loxapine	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Loxapine 是 D2DR 和 D4DR 抑制剂和5-羟色胺能受体拮抗剂，是一种抗精神病药物，主要用于治疗精神分裂症。
T9183	Ralmitaront RO6889450	Others	Others
	Ralmitaront (RO6889450) 是口服具有活力的口服微量胺相关受体 1 (TAAR1) 的部分激动剂。它是一种神经抑制剂，可用于研究神经相关疾病，如精神分裂症 (SCZ)、分裂情感性障碍。
T21667	FAUC-365	Dopamine Receptor	GPCR/G Protein; Neuroscience
	FAUC-365 是一种高度选择性的多巴胺D3受体拮抗剂，能够作用于 D3 受体(Ki:0.5 nM)、D4.4 受体(Ki:340 nM)、D2short 受体(Ki:2600 nM)和 D2Long 受体(Ki:3600 nM)。它可用于研究帕金森病、精神分裂症等疾病。
T7549	Talnetant SB 223412	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Talnetant (SB 223412) 是一种选择性、竞争性、脑渗透性 NK3 受体拮抗剂，Ki 为1.4 nM。它比对hNK-2受体的抑制性高100倍，具有调节中脑边缘和中脑皮质多巴胺能神经传递的能力。
T5183	AUT1	Potassium Channel	Membrane transporter/Ion channel
	AUT1 是 Kv3 钾离子通道调节剂，对人重组 Kv3.1b 和 Kv3.2a 的pEC50值分别为 5.33 和 5.31，对其活性是对人重组 Kv3.3 通道的 10 倍，pEC50值为 4.5。
T13189	TP-10	PDE	Metabolism
	TP-10 是 PDE10A 对其他 PDE 的特异性抑制剂，IC50 为 0.8 nM。
T29137	VU0453595 VU 0453595,VU-0453595	AChR	Neuroscience
	VU0453595 是有效的、高选择性的、全身活性的M1正变构调节剂 (PAM, EC50=2140 nM)，在精神分裂症方面有研究价值。
T9694	Emraclidine CVL-231	AChR	Neuroscience
	Emraclidine (CVL-231) 是一种毒蕈碱 M4 受体阳性变构调节剂，可用于神经系统疾病研究。
T23348	SEN12333 SEN 12333	AChR	Neuroscience
	SEN12333 是强选择性和口服活性的 α7 nAChR 激动剂，可以用于 AD 和精神分裂症研究。它在功能性 Ca2+通量研究中起到完全激动剂的作用，对 GH4C1 细胞中表达的大鼠 α7 nAChRs 具有很高的亲和性。
T11095L	DREADD agonist 21	5-HT Receptor; Adrenergic Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	DREADD agonist 21 是一种人毒蕈碱乙酰胆碱 M3 受体激动剂，EC50为 1.7 nM。
T15260	Evenamide NW-3509	Sodium Channel	Membrane transporter/Ion channel
	Evenamide (NW-3509) 是一种口服有效的电压门控钠通道 (sodium channel, VGSC) 阻滞剂，Ki 为 0.4 µM，在精神分裂症中有研究价值。Evenamide 在精神病，躁狂症，抑郁和攻击性的各种啮齿动物模型中具有显著功效。
T14830	Bromperidol 溴哌利多,R-11333	5-HT Receptor	GPCR/G Protein; Neuroscience
	Bromperidol (R-11333) 是一种苯丁酮衍生物，是一种强效长效精神安定药。它被用作治疗精神分裂症的抗精神病药。
T1539	Iloperidone 伊潘立酮,HP 873	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Iloperidone (HP 873) 是一种D2/5-HT2受体拮抗剂，是非典型抗精神病药，可治疗精神分裂症。
T7943	Fluphenazine decanoate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂，是一种长效吩噻嗪抗精神病药，用于精神分裂症的研究。
T11722	JNJ-37822681 dihydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	JNJ-37822681 dihydrochloride 是特异性的、有中枢活性的，可快速解离的多巴胺 D2受体拮抗剂，与多巴胺 D2L 受体结合的亲和力适中 (Ki=158 nM)。JNJ-37822681 dihydrochloride 在精神分裂症和躁郁症领域有研究价值。
T0246	Betahistine dihydrochloride PT-9,Betahistine 2HCl,盐酸倍他司汀	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Betahistine dihydrochloride (Betahistine 2HCl) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂，可用作血管扩张剂，用于类风湿性关节炎的研究。
T4195	Betahistine PT 9 base,倍他司汀,Vasomotal,Serc base	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Betahistine (Vasomotal) 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂，可用作血管扩张剂，用于类风湿性关节炎的研究。
T3086	Mesoridazine Besylate Mesoridazine benzenesulfonate,Serentil,苯磺酸美索达嗪	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Mesoridazine Besylate (Serentil) 是一种哌啶类精神安定药，属于称为吩噻嗪类的药物，用于治疗精神分裂症。它是硫利达嗪的代谢物。
T25487	Haloperidol decanoate KD 16,KD-136,KD 136,Neoperidole,Haldol	Others	Others
	Haloperidol decanoate (KD 16) 是一种典型的抗精神病药物，用作精神分裂症和情绪障碍的维持治疗，配制成用于肌肉注射的酯。
T24656	PQ-10 A844337,PQ 10,A-844337,A 844337	PDE	Metabolism
	PQ-10 (A-844337) 是磷酸二酯酶 10A 抑制剂，其IC50=4.6 nM，ED50=13 mg/kg。它能够诱导大脑葡萄糖代谢模式，这可能是潜在的转化生物标志物。它对精神分裂症等精神疾病具有研究潜力。
T9317	TAK-041 NBI-1065846	GPR	Endocrinology/Hormones; GPCR/G Protein
	TAK-041 (NBI-1065846) 是一种选择性 GPR139激动剂，EC50为 22 nM，有用于精神分裂症阴性症状的研究潜力。
T28368	PF-04859989 HCl PF 04859989,PF04859989,PF-04859989HCl,PF-04859989	Others	Others
	PF-04859989 HCl 是不可逆的犬尿氨酸转氨酶 KAT II 抑制剂，可透过血脑屏障，抑制 hKATⅡ 和 rKATⅡ 的 IC50分别为 23 和 263 nM。它对 KATⅡ 的选择性高于人 KATⅠ、KATⅢ 和 KATⅣ (IC50分别为22、11和 >50 μM)。
T1180	Blonanserin 布南色林,AD-5423	Dopamine Receptor; Sigma receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Blonanserin (AD-5423) 是一种有效的5-HT2A 和多巴胺 D2 受体拮抗剂，Ki 为 0.812 和 0.142 nM，是一种非典型的抗精神病试剂。
T8389	Trifluoperazine 三氟拉嗪,trifluoroperazine	CaMK; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; P-gp; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Trifluoperazine (trifluoroperazine) 是一种多巴胺 D2 受体抑制剂，可治疗精神分裂症。它是NUPR1抑制剂，具有抗癌活性。它是α1-adrenergic 受体拮抗剂，是流感病毒形态发生的可逆抑制剂。
T7476	AS057278 3-Methylpyrazole-5-carboxylic acid,5-甲基-1H-吡唑-3-羧酸	Others	Others
	AS057278 (3-Methylpyrazole-5-carboxylic acid) 是一种 D-氨基酸氧化酶 (DAAO) 抑制剂。
TQ0084	lumateperone Tosylate ITI-007,Lumateperone甲苯磺酸盐	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	lumateperone Tosylate (ITI-007) 是5-HT 2A 受体拮抗剂，Ki 为 0.54 nM，突触前 D2受体的部分激动剂和突触后 D2受体的拮抗剂，Ki 为 32 nM。
T1412	Loxapine succinate Daxolin,Loxapac,Cloxazepin,Loxapine succinate salt,丁二酸洛沙平,琥珀酸洛沙平	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Loxapine succinate (Loxapac) 是D2/D4多巴胺受体，5-羟色胺受体抑制剂，用于精神分裂症。
T0455	Clozapine 氯氮平,HF 1854,LX 100-129	Dopamine Receptor; Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	Clozapine (HF 1854) 是一种三环二苯二氮卓类药物，属于非典型抗精神病药物。它结合几种类型的中枢神经系统受体，并显示出独特的药理学特征。它是一种血清素拮抗剂，与 5-HT 2A/2C 受体亚型具有强结合力。它还对几种多巴胺能受体表现出很强的亲和力，但对多巴胺 D2 受体仅表现出较弱的拮抗作用，这种受体通常被认为可调节精神抑制活性。
T3619	VU0357017 hydrochloride ML071 hydrochloride,CID-25010775,VU 0357017 hydrochloride,盐酸 VU 0357017	AChR	Neuroscience
	VU0357017 hydrochloride (ML071 hydrochloride) 是一种选择性和可透过血脑屏障的M1毒蕈碱乙酰胆碱受体变构激动剂，EC50值为 477 nM。它对 M1具有高度选择性，可用于阿尔茨海默症和精神分裂症的研究。
T21069	Lumateperone ITI 722,ITI722,ITI-007,卢美哌隆,ITI007	5-HT Receptor	GPCR/G Protein; Neuroscience
	Lumateperone (ITI 722) 是一种 5HT2A 受体拮抗剂和多巴胺受体磷蛋白调节剂 (DPPM)。
T1884	CX516 Ampakine CX516,BDP 12,Ampalex,安帕来斯	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	CX516 (Ampalex) 是AMPA 受体正向调节剂，可用于研究阿尔茨海默病，精神分裂等。
T5135	Flupentixol dihydrochloride 盐酸氟哌噻吨,Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Flupentixol dihydrochloride 是噻克西酮类试剂，能够用于研究精神分裂症以及抗焦虑和抑郁障碍。
T10232	Acetophenazine dimaleate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Acetophenazine dimaleate 是抗精神病试剂，能够有效治疗焦虑抑郁。
T1222	Trifluoperazine dihydrochloride Trifluoperazine 2HCl,盐酸三氟拉嗪,SKF5019,Urinox	CaMK; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; P-gp; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Trifluoperazine dihydrochloride (SKF5019) 是一种抗精神病药物，靶向中枢多巴胺受体。它是流感病毒形态发生的可逆抑制剂，是NUPR1抑制剂，具有抗癌活性。它是钙调蛋白抑制剂，还可抑制 P-糖蛋白，可研究精神分裂症。
T9827	carfenazine	Dopamine Receptor	GPCR/G Protein; Neuroscience
	carfenazine 靶向多巴胺受体，用于精神分裂症研究。
T27865	LX-6171 LX6171	Others	Others
	LX-6171是一种脯氨酸转运体（SLC6A7）抑制剂，可用于治疗精神分裂症和阿尔茨海默病。
T39010	Xanomeline tartrate LY 246708 tartrate,Xanomeline tartrate	Others	Others
	Xanomeline (LY 246708), a potent agonist of muscarinic M1/M4 receptors, exhibits antipsychotic-like activity and enhances neuronal excitability. It is a valuable compound for studying schizophrenia.
T30098	Aplindore Fumarate Aplindore,DAB-452 Fumarate,DAB-452	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Aplindore Fumarate （DAB-452）是一种小分子多巴胺 D2 受体部分激动剂，Aplindore Fumarate 对多巴胺D2 和D3 受体表现出高亲和力，对多巴胺D4、5-羟色胺（5-HT2）和α1-肾上腺素受体表现出低亲和力。Aplindore Fumarate 可用于研究帕金森和精神分裂症。
T34616	Seridopidine ACR-343,ACR 343,ACR343	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Seridopidine (ACR343) 是一种多巴胺能活性调节剂，可作为精神分裂症、帕金森病和抽动秽语综合征的口服疗法。
T23900	Clothiapine S-805C,HF2159,HF 2159,HF-2159,LW 2159	5-HT Receptor	GPCR/G Protein; Neuroscience
	Clothiapine (HF 2159) 是一种非典型抗精神病剂，具有很强的抗 5-羟色胺能和血清素能活性活性，可用于研究精神分裂。
T32633	Lensiprazine SLV314,SLV-314,SLV 314	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Lensiprazine (SLV314)是一种有效的多巴胺 D(2)受体拮抗剂，可作为一种血清素再摄取抑制剂，可用于研究躁郁症和精神分裂症。
T23649	AF-710B ANAVEX 3-71,AF 710B,AF710B	Sigma receptor; AChR	GPCR/G Protein; Neuroscience
	AF-710B 是一种特异性变构 M1 毒蕈碱和 Sigma-1 受体激动剂，可用于研究阿尔茨海默病痴呆和神经分裂等神经系统疾病。
T24613	PF-00217830 PF-217830	Dopamine Receptor; Serotonin Transporter	GPCR/G Protein; Neuroscience
	PF-00217830 是一种血清素 1A 受体激动剂、多巴胺 D2 受体激动剂和血清素 2A 受体拮抗剂。PF-00217830 可用于研究精神分裂症。
TP1270L	2:PN:US20040072744 SEQID:2 claimed protein acetate 2:PN:US20040072744 SEQID:2 claimed protein acetate(389572-87-6 free base)	Others	Others
	2:PN:US20040072744 SEQID:2 claimed protein acetate 是一种合成肽，用于唐氏综合症和精神分裂症的研究。
T1567	Olanzapine LY170053,奥氮平	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	Olanzapine (LY170053) 是一种非典型抗精神病药，目前用于治疗精神分裂症和双相情感障碍。
T31079	CP-810123 CP 810123,UNII-E6G4550EC4,CP810123	AChR	Neuroscience
	CP-810123 是一种新的α 7 nAChR 激动剂，可用于治疗与精神分裂症和阿尔茨海默病等精神或神经疾病相关的认知障碍。
T28809	SLV-310 SLV 310,SLV310	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	SLV-310 是一种强效的多巴胺 D2 受体拮抗剂和 5-HT 再摄取受体抑制剂，可用于研究躁郁症和精神分裂症等神经系统疾病。
T84293	SSR 180 SSR180711	AChR	Neuroscience
	SSR 180 是一种高效性且亚型选择性的 α7 激动剂具有可用于研究阿尔茨海默病和精神分裂症。

化合物

Aripiprazole Lauroxil

Cat.No: T14319

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T8862

Target: GluR

Cat.No: T21629

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T9183

Synonym: RO6889450

Target: Others

Cat.No: T21667

Target: Dopamine Receptor

Cat.No: T7549

Synonym: SB 223412

Target: Neurokinin receptor

Cat.No: T5183

Target: Potassium Channel

Cat.No: T13189

Target: PDE

Cat.No: T29137

Synonym: VU 0453595,VU-0453595

Target: AChR

Cat.No: T9694

Synonym: CVL-231

Target: AChR

Cat.No: T23348

Synonym: SEN 12333

Target: AChR

DREADD agonist 21

Cat.No: T11095L

Target: 5-HT Receptor, Adrenergic Receptor, AChR, Histamine Receptor

Cat.No: T15260

Synonym: NW-3509

Target: Sodium Channel

Cat.No: T14830

Synonym: 溴哌利多,R-11333

Target: 5-HT Receptor

Cat.No: T1539

Synonym: 伊潘立酮,HP 873

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Fluphenazine decanoate

Cat.No: T7943

Target: Dopamine Receptor

JNJ-37822681 dihydrochloride

Cat.No: T11722

Target: Dopamine Receptor

Betahistine dihydrochloride

Cat.No: T0246

Synonym: PT-9,Betahistine 2HCl,盐酸倍他司汀

Target: Histamine Receptor

Cat.No: T4195

Synonym: PT 9 base,倍他司汀,Vasomotal,Serc base

Target: Histamine Receptor

Mesoridazine Besylate

Cat.No: T3086

Synonym: Mesoridazine benzenesulfonate,Serentil,苯磺酸美索达嗪

Target: Dopamine Receptor, 5-HT Receptor

Haloperidol decanoate

Cat.No: T25487

Synonym: KD 16,KD-136,KD 136,Neoperidole,Haldol

Target: Others

Cat.No: T24656

Synonym: A844337,PQ 10,A-844337,A 844337

Target: PDE

Cat.No: T9317

Synonym: NBI-1065846

Target: GPR

PF-04859989 HCl

Cat.No: T28368

Synonym: PF 04859989,PF04859989,PF-04859989HCl,PF-04859989

Target: Others

Cat.No: T1180

Synonym: 布南色林,AD-5423

Target: Dopamine Receptor, Sigma receptor, 5-HT Receptor, Adrenergic Receptor

Trifluoperazine

Cat.No: T8389

Synonym: 三氟拉嗪,trifluoroperazine

Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy

Cat.No: T7476

Synonym: 3-Methylpyrazole-5-carboxylic acid,5-甲基-1H-吡唑-3-羧酸

Target: Others

lumateperone Tosylate

Cat.No: TQ0084

Synonym: ITI-007,Lumateperone甲苯磺酸盐

Target: Dopamine Receptor, 5-HT Receptor

Loxapine succinate

Cat.No: T1412

Synonym: Daxolin,Loxapac,Cloxazepin,Loxapine succinate salt,丁二酸洛沙平,琥珀酸洛沙平

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T0455

Synonym: 氯氮平,HF 1854,LX 100-129

Target: Dopamine Receptor, Adrenergic Receptor, AChR

VU0357017 hydrochloride

Cat.No: T3619

Synonym: ML071 hydrochloride,CID-25010775,VU 0357017 hydrochloride,盐酸 VU 0357017

Target: AChR

Cat.No: T21069

Synonym: ITI 722,ITI722,ITI-007,卢美哌隆,ITI007

Target: 5-HT Receptor

Cat.No: T1884

Synonym: Ampakine CX516,BDP 12,Ampalex,安帕来斯

Target: GluR, iGluR

Flupentixol dihydrochloride

Cat.No: T5135

Synonym: 盐酸氟哌噻吨,Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride

Target: Dopamine Receptor

Acetophenazine dimaleate

Cat.No: T10232

Target: Dopamine Receptor

Trifluoperazine dihydrochloride

Cat.No: T1222

Synonym: Trifluoperazine 2HCl,盐酸三氟拉嗪,SKF5019,Urinox

Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy

Cat.No: T9827

Target: Dopamine Receptor

Cat.No: T27865

Synonym: LX6171

Target: Others

Xanomeline tartrate

Cat.No: T39010

Synonym: LY 246708 tartrate,Xanomeline tartrate

Target: Others

Aplindore Fumarate

Cat.No: T30098

Synonym: Aplindore,DAB-452 Fumarate,DAB-452

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Cat.No: T34616

Synonym: ACR-343,ACR 343,ACR343

Target: Dopamine Receptor

Cat.No: T23900

Synonym: S-805C,HF2159,HF 2159,HF-2159,LW 2159

Target: 5-HT Receptor

Cat.No: T32633

Synonym: SLV314,SLV-314,SLV 314

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T23649

Synonym: ANAVEX 3-71,AF 710B,AF710B

Target: Sigma receptor, AChR

Cat.No: T24613

Synonym: PF-217830

Target: Dopamine Receptor, Serotonin Transporter

2:PN:US20040072744 SEQID:2 claimed protein acetate

Cat.No: TP1270L

Synonym: 2:PN:US20040072744 SEQID:2 claimed protein acetate(389572-87-6 free base)

Target: Others

Cat.No: T1567

Synonym: LY170053,奥氮平

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR

Cat.No: T31079

Synonym: CP 810123,UNII-E6G4550EC4,CP810123

Target: AChR

Cat.No: T28809

Synonym: SLV 310,SLV310

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T84293

Synonym: SSR180711

Target: AChR

Cat. No.	Product Name	Target	Signaling Pathways
T0076	Paliperidone 9-羟基利培酮,帕潘立酮,9-hydroxyrisperidone	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Paliperidone (9-hydroxyrisperidone) 是 Risperidone 的主要活性代谢产物，是多巴胺 D2 拮抗剂和5-HT2A 拮抗剂。它用作非典型抗精神病药，用于精神分裂症的急性及维持治疗。它对α1和α2肾上腺素能受体和 H1组胺能受体也有拮抗作用。
T6975	Sarcosine Sarcosinic acid,Methylaminoacetic acid,Sarcosin,肌氨酸,Methylglycine,N-Methylaminoacetic acid,N-methylglycine	Others; GlyT; Endogenous Metabolite	Metabolism; Neuroscience; Others
	Sarcosine (Methylglycine) 是 I 型甘氨酸转运蛋白 (GlyT1) 的竞争性抑制剂和 N-甲基-D-天冬氨酸受体 (NMDAR) 共激动剂，通过增加甘氨酸的浓度增强 NMDA 受体的功能，可用于精神分裂症的研究。
T4877	L-Homocystine	Endogenous Metabolite	Metabolism
	L-Homocystine 是一种 L-homocysteine 的氧化物。其中 L-homocysteine 是抗血栓因子、血管舒张损害剂、促炎因子，也是研究心血管疾病发生机制的内质网应激反应的诱导剂。

天然产物

Cat.No: T0076

Synonym: 9-羟基利培酮,帕潘立酮,9-hydroxyrisperidone

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

Cat.No: T6975

Synonym: Sarcosinic acid,Methylaminoacetic acid,Sarcosin,肌氨酸,Methylglycine,N-Methylaminoacetic acid,N-methylglycine

Target: Others, GlyT, Endogenous Metabolite

Cat.No: T4877

Target: Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05054	Notch 4 Protein, Human, Recombinant (His) INT3,notch 4	Human	Baculovirus Insect Cells
	NOTCH4 (Notch Receptor 4) is a Protein Coding gene. Notch4 belongs to a family of transmembrane receptors that play an important role in vascular development and maintenance. The NOTCH4 gene is located at 6p21.3 and is involved in the development and patterning of the central nervous systems. It regulates signaling pathways associated with neuronal maturation, a process involved in the development and patterning of the central nervous system. The NOTCH4 gene has also been identified as a possibl...
TMPY-02377	14-3-3 eta/YWHAH Protein, Human, Recombinant (GST) tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activati...	Human	E. coli
	YWHAH, the gene encoding the 14-3-3eta isoform, is highly expressed in retinal ganglion cells (RGC). YWHAH is a positional and functional candidate gene for both schizophrenia and bipolar disorder (BP). It is located on chromosome 22q12.3, a region that has been implicated by linkage studies in both BP and schizophrenia.
TMPK-01200	Nogo Receptor/RTN4R Protein, Cynomolgus, Recombinant (His) NGR,NOGOR,RTN4R,NgR1,Nogo receptor,Nogo-66 receptor	Cynomolgus	HEK293 Cells
	NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene.RTN4R may modulate the genetic risk or clinical expression of schizophrenia in a subset of patients and identify additional studies that will be necessary to clarify the role of RTN4R in psychiatric phenotypes.
TMPY-01120	VPAC2 Protein, Human, Recombinant (mFc) VPCAP2R,PACAP-R-3,VIP-R-2,vasoactive intestinal peptide rece...	Human	HEK293 Cells
	VIP and PACAP receptor 2, or VIPR2 encodes the VPAC2 receptor, which binds both VIP and PACAP. VPAC2 is expressed throughout the central nervous system and the periphery. Mutations in the VIPR2 homolog in the mouse cause hypoactivity, as well as disruptions in circadian rhythm. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia.
TMPJ-01271	PIK3IP1 Protein, Human, Recombinant (His) Kringle domain-containing protein HGFL,PIK3IP1,HGFL	Human	HEK293 Cells
	Phosphoinositide-3-kinase-interacting protein 1(PIK3IP1) is an enzyme that in humans is encoded by the PIK3IP1 gene.It is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepatocellular carcinoma. The gene encoding PIK3IP1 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibrom...
TMPJ-01296	SULT4A1 Protein, Human, Recombinant hBR-STL,SULTX3,Nervous System Sulfotransferase,SULT4A1,ST4A1...	Human	E. coli
	Sulfotransferase 4A1 (ST4A1) is a member of the Sulfotransferase 1 family. ST4A1 is highly expressed in the cerebral cortex and frontal lobe, but no expression is detected in the pancreas. ST4A1 is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. ST4A1 acts on catecholamines and T4 in a manner that may not involve sulfonation. ST4A1 may have a role in the metabolism of drugs and neurotransmitters in the CNS. In addition, ST4A1 is related to schizo...
TMPY-02511	PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST) LRP,PTP α/PTPRA Protein, Human, Recombinant (aa 174-793, His...	Human	Baculovirus Insect Cells
	PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and anima...
TMPJ-00383	SEMA3A Protein, Human, Recombinant (His & Flag) Hsema-III,SemD,SEMA3A,Semaphorin III,SEMAD,Hsema-I,Sema III,...	Human	HEK293 Cells
	emaphorin-3A is a secreted protein which belongs to the semaphorin family. Semaphorins are a family of secreted and cell-bound signaling molecules defined by the presence of a common 500 aa Sema domain.This protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with s...
TMPY-03852	Dopamine beta-Hydroxylase Protein, Human, Recombinant (His) dopamine β-hydroxylase (dopamine β-monooxygenase),Dopamine β...	Human	HEK293 Cells
	DBH is a 29 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH contains our identical subunits, and its activity requires ascorbate as a cofactor. It functions in in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only transmitter synthesized inside vesicles. DBH has been shown to be associated ...
TMPJ-00660	IMPase2 Protein, Human, Recombinant (His) Inositol-1(or 4)-Monophosphatase 2,IMPA2,IMP 2,IMPase 2,Inos...	Human	E. coli
	Inositol monophosphatase 2, also known as Inositol-1(or 4)-monophosphatase 2, Myo-inositol monophosphatase A2 and IMPA2, is an enzyme which belongs to the inositol monophosphatase family. IMPA2 catalyzes the dephosphoylration of inositol monophosphate with cofactor Magnesium and Inhibited by high Li+ and restricted Mg2+ concentrations. IMPA2 plays an important role in phosphatidylinositol signaling. IMPA2 can use the myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphat...
TMPY-03276	BLBP Protein, Human, Recombinant fatty acid binding protein 7, brain,FABPB,MRG,B-FABP,BLBP,RP...	Human	E. coli
	BLBP, also known as FABP7, is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP7 binds DHA with the highest affinity among all of the FABPs. FABPs may play roles in fatty acid uptake, transport, and metabolism. BLBP is expressed, during development, in radial glia by the activation of notch receptors. It was shown that reelin induces FABP7 expre...
TMPY-04408	CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST) calcium/calmodulin-dependent protein kinase II beta,CAM2,CAM...	Human	Baculovirus Insect Cells
	Calcium/calmodulin-dependent protein kinase II beta (CAMK2B) is a member of the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. CaMKII is an important player in prostate cancer cells ability to escape apoptosis under androgen ablation and facilitate the progression of prostate cancer cells to an androgen independent state. As a multifunctional protein kinase, the loss of activity may play a critical role in initiating the changes leading to...
TMPY-01695	CASPR2 Protein, Mouse, Recombinant (His) 5430425M22Rik,Caspr2,contactin associated protein-like 2,mKI...	Mouse	HEK293 Cells
	CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2/CASPR2 is localized at the juxtaparanodes of myelinated axons, and media...

重组蛋白

Notch 4 Protein, Human, Recombinant (His)

Cat.No: TMPY-05054

Species: Human

Expression System: Baculovirus Insect Cells

14-3-3 eta/YWHAH Protein, Human, Recombinant (GST)

Cat.No: TMPY-02377

Species: Human

Expression System: E. coli

Nogo Receptor/RTN4R Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01200

Species: Cynomolgus

Expression System: HEK293 Cells

VPAC2 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-01120

Species: Human

Expression System: HEK293 Cells

PIK3IP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01271

Species: Human

Expression System: HEK293 Cells

SULT4A1 Protein, Human, Recombinant

Cat.No: TMPJ-01296

Species: Human

Expression System: E. coli

PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)

Cat.No: TMPY-02511

Species: Human

Expression System: Baculovirus Insect Cells

SEMA3A Protein, Human, Recombinant (His & Flag)

Cat.No: TMPJ-00383

Species: Human

Expression System: HEK293 Cells

Dopamine beta-Hydroxylase Protein, Human, Recombinant (His)

Cat.No: TMPY-03852

Species: Human

Expression System: HEK293 Cells

IMPase2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00660

Species: Human

Expression System: E. coli

BLBP Protein, Human, Recombinant

Cat.No: TMPY-03276

Species: Human

Expression System: E. coli

CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04408

Species: Human

Expression System: Baculovirus Insect Cells

CASPR2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01695

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T74145	Deutarserine
	Deutarserine 是内源性 D-丝氨酸 (CTP 692) 的氘代物，用于成人精神分裂症的研究。
TMIJ-0322	Olanzapine-d8
	Olanzapine-d8 是 Olanzapine 的氘代化合物。Olanzapine 的 CAS 号为 132539-06-1。Olanzapine 是一种非典型抗精神病药，目前用于治疗精神分裂症和双相情感障碍。
TMID-0025	Quetiapine-d8 Hemifumarate
	Quetiapine-d8 Hemifumarate 是 Quetiapine Hemifumarate 的氘代化合物。Quetiapine Hemifumarate 的 CAS 号为 111974-72-2。Quetiapine Fumarate 是5-HT受体激动剂和多巴胺受体拮抗剂，对人5-HT1A和人D2的pEC50值分别为 4.77 和 6.33，具有抗抑郁和抗焦虑作用。
TMIJ-0315	Quetiapine-d8 Fumarate
	Quetiapine-d8 Fumarate 是 Quetiapine Fumarate 的氘代化合物。Quetiapine Fumarate 的 CAS 号为 111974-72-2。Quetiapine Fumarate 是5-HT受体激动剂和多巴胺受体拮抗剂，对人5-HT1A和人D2的pEC50值分别为 4.77 和 6.33，具有抗抑郁和抗焦虑作用。
TMID-0053	Amisulpride-d5
	Amisulpride-d5 是 Amisulpride 的氘代化合物。Amisulpride 的 CAS 号为 71675-85-9。Amisulpride 是多巴胺D2/D3受体拮抗剂，对于人多巴胺D2和D3的Ki分别为 2.8 和 3.2 nM。
TMIH-0427	Perospirone hydrochloride-d8
	Perospirone hydrochloride-d8 是 Perospirone hydrochloride 的氘代化合物。Perospirone hydrochloride 的 CAS 号为 129273-38-7。Perospirone hydrochloride 是非典型的抗精神病剂，可用于精神分裂症的研究。它是可口服的5-HT2A受体和多巴胺D2受体的拮抗剂，也是5-HT1A受体的部分激动剂。
TMIJ-0269	Perospirone-d8 HCl
	Perospirone-d8 HCl 是 Perospirone HCl 的氘代化合物。Perospirone HCl 的 CAS 号为 129273-38-7。Perospirone hydrochloride 是非典型的抗精神病剂，可用于精神分裂症的研究。它是可口服的5-HT2A受体和多巴胺D2受体的拮抗剂，也是5-HT1A受体的部分激动剂。
TMIH-0314	Lurasidone-d8 HCl
	Lurasidone-d8 HCl 是 Lurasidone HCl 的氘代化合物。Lurasidone HCl 的 CAS 号为 367514-88-3。Lurasidone hydrochloride 是多巴胺 D2和5-HT7的拮抗剂，IC50值分别为 1.68 和 0.495 nM，用于治疗精神分裂症和双相情感障碍。它也是5-HT1A受体的部分激动剂，IC50值为 6.75 nM。
TMIH-0420	Paliperidone-d4
	Paliperidone-d4 是 Paliperidone 的氘代化合物。Paliperidone 的 CAS 号为 144598-75-4。Paliperidone 是 Risperidone 的主要活性代谢产物，是多巴胺 D2 拮抗剂和5-HT2A拮抗剂。它用作非典型抗精神病药，用于精神分裂症的急性及维持治疗。它对α1和α2肾上腺素能受体和H1组胺能受体也有拮抗作用。

同位素标记化合物

Cat.No: T74145

Cat.No: TMIJ-0322

Quetiapine-d8 Hemifumarate

Cat.No: TMID-0025

Quetiapine-d8 Fumarate

Cat.No: TMIJ-0315

Cat.No: TMID-0053

Perospirone hydrochloride-d8

Cat.No: TMIH-0427

Perospirone-d8 HCl

Cat.No: TMIJ-0269

Lurasidone-d8 HCl

Cat.No: TMIH-0314

Paliperidone-d4

Cat.No: TMIH-0420

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼