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23
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7844 |
4-IPP
4-Iodo-6-phenylpyrimidine |
Others | Others |
4-IPP (4-Iodo-6-phenylpyrimidine) 是一种巨噬细胞迁移抑制因子 (MIF) 的特异性自杀底物,也是 MIF 的不可逆抑制剂。 | |||
T13324 |
VUF11207 fumarate
|
CXCR; Arrestin | Autophagy; GPCR/G Protein; Immunology/Inflammation |
VUF11207 fumarate 是一种 CXCR7激动剂和高效CXCR7配体,pKi 为 8.1。它可诱导CXCR7的β-arrestin2募集和随后的内在化,pEC50分别为 8.8 和 7.9。 | |||
T15718 |
Latanoprost acid
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
Latanoprost acid 是前列腺素受体的选择性激动剂,通过抑制 c-fos/NFATc1 通路抑制 RANKL 诱导的破骨细胞生成和功能。 拉坦前列素酸可用于降低眼内压力的研究。 | |||
T69778 |
iso-Dehydrozingerone
|
Others | Others |
iso-Dehydrozingerone is a novel osteoclastogenesis inhibitor, preventing ovariectomy-induced osteoporosis in ddY mice. | |||
T27526 |
Halenaquinone
|
Others | Others |
Halenaquinone is a phosphatidylinositol 3-kinase inhibitor. Halenaquinone specifically inhibits the secondary DNA binding of RAD51. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Halenaquinone induces apoptosis in PC12 cells. | |||
T70983 |
Zoledronate disodium
|
Others | Others |
Zoledronate disodium is an inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma. | |||
T70062 |
Osteoprotegerin
|
Others | Others |
Osteoprotegerin is a soluble secreted member of the tumor necrosis factor receptor superfamily, inhibiting osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, leading to excess accumulation of bone and cartilage. | |||
T83226 |
A3373
|
Phospholipase | Metabolism |
A3373 是新型 PLD1 和 PLD2 抑制剂,对 PLD1 的 IC50 为 325 nM ,对 PLD2 的 IC50 为 15.15 µM,能够有效抑制 LPS 诱导的免疫反应,并在自身免疫性关节炎、骨脱矿及破骨细胞生成等方面发挥关键作用。 | |||
T81171 |
SH491
|
Others | Others |
SH491(Compound 33)是一款抗骨质疏松药物。该化合物能够抑制RANKL诱导的骨髓源性单核细胞(BMM)分化为破骨细胞(IC50: 11.8 nM)。同时,SH491降低了破骨细胞形成的相关标记基因(TRAP、CTSK、MMP-9和ATPase v0d2)以及相应蛋白(TRAP、CTSK、MMP-9)的表达。 | |||
T78816 |
Anti-osteoporosis agent-4
|
NF-κB | NF-κB |
Anti-osteoporosis agent-4 (Compound 11h) 在生物医学领域中表现为有效抑制原代破骨细胞的分化,减弱RANKL诱导的破骨细胞生成,并展示出强抑制作用,具有 IC50 值为358.29 nM。此外,该化合物还能抑制关键的 PI3K/AKT 和 IκBα/NF-κB 信号通路激活,表明其在防治骨质疏松症中的潜在应用价值。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1712 |
Gossypin
|
NF-κB; S6 Kinase | MAPK; NF-κB; PI3K/Akt/mTOR signaling |
Gossypin 是一种从Hibiscus vitifolius 中分离得到的黄酮,能够抑制NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中,它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。 | |||
T5S2129 |
Sciadopitysin
|
TNF; NF-κB | Apoptosis; NF-κB |
Sciadopitysin 是一种双黄酮类化合物,来自银杏叶片中。它通过抑制NF-κB 活化并降低c-Fos 和NFATc1的表达来抑制 RANKL 诱导的破骨细胞生成和骨丢失。 | |||
T3807 |
(-)-Gallocatechin gallate
(-)-gallocatechin-3-O-gallate,(-)-Gallocatechol gallate,没食子儿茶素没食子酸酯,Gallocatechin gallate |
Others | Others |
(-)-Gallocatechin gallate ((-)-gallocatechin-3-O-gallate) 是一种从茶中分离出来的多酚,具有防癌活性。 它在 20 microM 时降低破骨细胞生成。 | |||
TN5086 |
Syringetin
|
Others | Others |
Syringetin 是一种存在于葡萄和葡萄酒中的类黄酮衍生物,可促进 B16F10 细胞的黑色素生成,抑制人肺腺癌中成骨细胞介导的破骨细胞生成。 | |||
T13768 |
(+)-Medicarpin
|
Estrogen/progestogen Receptor | Endocrinology/Hormones |
(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from multiple medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium floribundum. It exhibits potent inhibition of osteoclastogenesis and facilitates bone healing and increased bone mass through osteoblast differentiation, which is mediated by the estrogen receptor (ER) β. | |||
T7437 |
3-(3-Hydroxyphenyl)propionic Acid
m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid,3-(3-羟基苯基)丙酸 |
Others; Endogenous Metabolite | Metabolism; Others |
3-(3-Hydroxyphenyl)propionic Acid (m-Hydroxyphenylpropionic acid) 是一种黄酮类代谢产物,由人体微生物区系形成,具有舒张血管的特性。 | |||
T5770 |
Alisol B
|
RANKL/RANK | NF-κB |
Alisol B 是一种具有用于骨科疾病研究潜力的化合物,通过分化破骨细胞发挥其功能。 | |||
TN3209 |
3′,4′,7-Trihydroxyflavone
|
ATPase; Others; p38 MAPK; NF-κB | MAPK; Membrane transporter/Ion channel; NF-κB; Others |
3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。 | |||
T6S0923 |
Hypericin
Hypericine,金丝桃素,Cyclosan |
Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Hypericin (Cyclosan) 是贯叶连翘的提取物,有抗菌、抗病毒、抗肿瘤和抗抑郁作用。 | |||
TN1215 |
(2S)-2'-Methoxykurarinone
2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone |
Akt; Antifection | Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling |
(2S)-2'-Methoxykurarinone 是一种分离自苦参根中的化合物,具有抗炎、解热、抗糖尿病和抗肿瘤活性。它对人髓系白血病 HL-60 细胞具有细胞毒活性。它能够下调 RANKL 信号,抑制破骨细胞形成和骨吸收。 | |||
T3849 |
Kinsenoside
金线莲苷,(+)-Kinsenoside |
Apoptosis; Nrf2 | Apoptosis; Immunology/Inflammation |
Kinsenoside ((+)-Kinsenoside) 是从金盏花属植物中分离得到的主要活性成分,以 Nrf2 依赖的方式保护髓核细胞在氧化应激下的生存能力,防止细胞凋亡、衰老和线粒体功能障碍。它显示出显着的抗肝毒性和抗炎活性。 | |||
T6S1966 |
Curculigoside
Curculigoside A,仙茅苷 |
Antioxidant; NF-κB; JAK; STAT | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells |
Curculigoside (Curculigoside A) 是仙茅中的主要皂苷,具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径,具有抗关节炎作用。 | |||
TN1141 |
Isodeoxyelephantopin
异去氧苦地胆素,异去氧苦地胆苦素 |
NF-κB; Reactive Oxygen Species; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; NF-κB |
Isodeoxyelephantopin 是从地胆草中分离得到的一种倍半萜烯内酯,能调节 LncRNA 的表达,有抗乳腺癌的作用。它可诱导活性氧的生成,抑制 NF-κB 的激活。 | |||
T38799 |
2,3-Bis(3-indolylmethyl)indole
|
Others | Others |
2,3-Bis(3-indolylmethyl)indole exhibits concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption. | |||
T83151 |
Ajudecunoid A
|
||
Ajudecunoid A, 一种从Ajuga decumbens分离的天然产物,具有抑制RANKL诱导的破骨细胞生成的活性。 | |||
T16846 |
Sauristolactam
Saurolactam |
Others | Others |
Sauristolactam inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation. Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus Chi | |||
TN3709 |
Coronarin D ethyl ether
|
NF-κB | NF-κB |
Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.It shows promising antifungal activity against C. albicans in vitro. | |||
TN1663 |
Ganoderic acid DM
灵芝酸DM,灵芝酸 DM |
PARP; Androgen Receptor; CDK | Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones |
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane pr | |||
T79932 |
Eudebeiolide B
Plebeiolide D |
NF-κB | NF-κB |
Eudebeiolide B,一种自荔枝草分离得的化合物,能通过调控RANKL诱导的NF-κB、c-Fos及钙信号来抑制破骨细胞的生成,适用于研究与破骨细胞相关的疾病。 | |||
T73205 |
Praelolide
|
Others | Others |
Praelolide是一种有效的Nrf2激活剂,能够抑制破骨细胞的生成与活性氧(ROS)的产生,并通过与Keap1的非共价结合,破坏Keap1-Nrf2蛋白质-蛋白质相互作用。因此,Praelolide展现出在破骨细胞性骨病研究中的应用潜力。 | |||
TN4094 |
Gallocatechin gallate
|
IL Receptor; NF-κB; ROS; MAPK; PPAR; Fatty Acid Synthase | DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; NF-κB |
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-κB signaling; it also may have anti-diabetic effects by increasing sensitivity | |||
TN5288 |
Ergosterol peroxide glucoside
过氧化麦角甾醇葡萄糖苷,Ergosterol peroxide 3-O-β-D-glucopyranoside |
||
Ergosterol peroxide exhibits anti-cancer, amoebicidal, anticomplementary, antibacterial, antiviral, anti-oxdiant, and anti-melanogenic activities. Ergosterol peroxide could as an anti-atherosclerosis agent, it exhibits hACAT-1 and Lp-PLA2 inhibitory effec | |||
TN3708 |
Coronarin D
|
BCL; c-Myc; TNF; NF-κB; Caspase; COX; Antifection | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome |
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively; it is active against tested Gram-positive bacteria, i |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01466 |
Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)
OPG,Tumor Necrosis Factor Receptor Superfamily Member 11B,OC... |
Human | HEK293 Cells |
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNF... | |||
TMPJ-00253 |
OPG Protein, Mouse, Recombinant (His)
Opg,Ocif,Tnfrsf11b,Osteoclastogenesis inhibitory fa... |
Mouse | HEK293 Cells |
Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG ... | |||
TMPH-01601 |
Lactoylglutathione lyase/GLO1 Protein, Human, Recombinant (GST)
Ketone-aldehyde mutase,Glyoxalase I,Lactoylglutathione lyase... |
Human | E. coli |
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. | |||
TMPK-01092 |
OSCAR Protein, Human, Recombinant (hFc)
Poly-Ig receptor 3,PIGR3,OSCAR,PIgR-3,MGC33613,mOSCAR |
Human | HEK293 Cells |
Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and normal patients. OSCAR and tartrate-resistant acid phosphatase (TRAP) expression levels did not differ between the cartilage pannus junction (CPJ) and non-CPJ regions in active RA. OSCAR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The p... | |||
TMPK-01117 |
OSCAR Protein, Mouse, Recombinant (hFc)
PIgR-3,Poly-Ig receptor 3,OSCAR,MGC33613,mOSCAR,PIGR3 |
Mouse | HEK293 Cells |
Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and normal patients. OSCAR and tartrate-resistant acid phosphatase (TRAP) expression levels did not differ between the cartilage pannus junction (CPJ) and non-CPJ regions in active RA. OSCAR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The p... | |||
TMPH-02264 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His)
Tumor necrosis factor ligand superfamily member 11,Osteoprot... |
Human | HEK293 Cells |
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multipl... |