376
19
2
8
3
Cat. No. | Product Name | ||
---|---|---|---|
L2600 | 神经信号分子库 | 2540 compounds | |
2540 种CNS 相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L2610 | 神经递质受体化合物库 | 1513 compounds | |
1513 种与神经递质受体相关的化合物,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12314 |
Opioid receptor modulator 1
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Opioid receptor modulator 1 is a modulator of opioid receptor. | |||
T62767 |
Mu opioid receptor antagonist 3
|
Others | Others |
Mu opioid receptor antagonist 3 (compound 26) 是一种有效的、选择性的、能透过血脑屏障渗透性的μ 阿片受体 (MOR) 拮抗剂 (Ki: 0.24 nM, EC50: 0.54 nM)。Mu opioid receptor antagonist 2 对吗啡表现出明显的中枢神经系统拮抗活性,诱发戒断症状比 Naloxone 小。Mu opioid receptor antagonist 2 能够用于研究阿片类药物使用障碍 (OUD)。 | |||
T62025 |
μ opioid receptor agonist 2
|
Others | Others |
μ opioid receptor agonist 2 (Compound H-3)是一种MOR 受体激动剂,可用于疼痛及疼痛相关疾病的研究。 | |||
T8991 |
BMS986187
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
BMS986187 是一种有效的δ-阿片受体选择性正变构调节剂 (PAM),其 EC50= 0.03 μM,pKB= 6.02 (~1 μM)。BMS986187 对 μ 受体无明显 PAM 活性 (EC50=3 μM)。 | |||
T4691 |
Asimadoline hydrochloride
EMD-61753 hydrochloride,阿西马朵林盐酸盐 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Asimadoline hydrochloride (EMD-61753 hydrochloride) 是一种 κ-阿片(κ-opioid)受体激动剂,对豚鼠和人重组 κ-opioid 的 IC50值分别为 5.6 和 1.2 nM。它可改善糖尿病大鼠的异常性疼痛,具有外周抗炎作用,并有用于肠易激综合征的研究潜力。 | |||
T9459 |
GR103545
|
Others | Others |
GR103545 是 κ-阿片受体的选择性激动剂,它是一种放射性示踪剂,可以用作体内成像。 | |||
T4351 |
DAMGO
Dagol,DAGO,RX-783006 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
DAMGO (DAGO) 是一种阿片受体激动剂,Kd 值为 3.46 nM。它能够影响啮齿动物的运动活动,可作为镇痛剂。 | |||
T79431 |
Mu opioid receptor antagonist 7
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Muopioid receptorantagonist 7 (compound 24) 是一种有效的CNS渗透性μOR (μ-阿片受体)拮抗剂,具有29 ± 3.0 nM的IC50。该化合物可用于研究疼痛和阿片类药物使用障碍。 | |||
T62766 |
Mu opioid receptor antagonist 2
|
Others | Others |
Mu opioid receptor antagonist 2 (compound 25) 是一种有效的、选择性的、能透过血脑屏障渗透性的μ 阿片受体 (MOR) 拮抗剂 (Ki: 0.37 nM, EC50: 0.44 nM)。Mu opioid receptor antagonist 2 对吗啡表现出明显的中枢神经系统拮抗活性,诱发戒断症状比 Naloxone 小。Mu opioid receptor antagonist 2 能够用于研究阿片类药物使用障碍 (OUD)。 | |||
T62768 |
Mu opioid receptor antagonist 4
|
Others | Others |
Mu opioid receptor antagonist 4 (compound 31) 是一种有效的、选择性的、能透过血脑屏障渗透性的μ 阿片受体 (MOR) 拮抗剂 (Ki: 0.38 nM, EC50: 0.38 nM)。Mu opioid receptor antagonist 2 对吗啡表现出明显的中枢神经系统拮抗活性,诱发戒断症状比 Naloxone 小。Mu opioid receptor antagonist 2 能够用于研究阿片类药物使用障碍 (OUD)。 | |||
T79430 |
μ opioid receptor agonist 3
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
μopioid receptor agonist3 (compound 20) 是高效的μOR激动剂,其EC50 值为0.87 nM。该化合物在疼痛和神经精神适应症研究中具备潜在应用价值。 | |||
T62268 |
μ opioid receptor agonist 1
|
Others | Others |
μ opioid receptor agonist 1 (Compound H-1a)是一种光学纯的氧杂环取代吡咯并吡唑衍生物,也是一种 MOR 受体激动剂,能够用于研究疼痛及疼痛相关疾病。 | |||
T61901 |
σ1 Receptor/μ Opioid receptor modulator 1
|
Others | Others |
σ1 Receptor/μ Opioid receptor modulator 1 (Compound 44) 是一种有效的σ1受体拮抗剂(Ki= 1.86 nM)和μ阿片受体激动剂(Ki=2.1 nM)。σ1 Receptor/μ Opioid receptor modulator 1 具体有效的镇痛活性,可用于神经性疼痛的研究。 | |||
T7748 |
Dermorphin TFA
皮啡肽三氟乙酸盐 |
Others; Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience; Others |
Dermorphin TFA 是在两栖类皮肤中发现的天然七肽,是 μ-阿片受体激动剂,可用于抑制神经痛。 | |||
T62673 |
Mu opioid receptor antagonist 5
|
Others | Others |
Mu opioid receptor antagonist 5 (compound NAP) 是一种选择性的、能够透过血脑屏障的 μ 阿片受体 (MOR) 拮抗剂 (EC50: 1.14 nM, Ki: 0.37 nM)。Mu opioid receptor antagonist 5 能够用于研究阿片类药物使用障碍 (OUD)。 | |||
T0918 |
Trimebutine
曲美布汀,Mebutin |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Trimebutine (Mebutin) 是阿片受体激动剂,有抗毒蕈碱活性。它是解痉剂,可调节肠道和结肠运动,并通过抗毒蕈碱和弱μ-阿片受体激动剂作用缓解腹痛。 | |||
TP1832 |
Gluten Exorphin C
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Gluten exorphin C 是来源于谷朊粉的阿片肽。在 GPI 和 MVD 检测中,抑制 μ 阿片和 δ 阿片活性,IC50值分别为 40 和13.5 μM。 | |||
TP1071 |
Nociceptin
Orphanin FQ,孤菲肽 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Nociceptin (Orphanin FQ) 是一种 17 个氨基酸的多肽,是 nociceptin 受体的内源性配体,具有缓解疼痛的作用。 | |||
T1242 |
Alvimopan
爱维莫潘 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Alvimopan (LY 246736) 是一种选择性和竞争性 μ 阿片受体拮抗剂,IC50值为 1.7 nM。它存在于肌间和黏膜下神经元以及人体肠道固有层的免疫细胞中,可用于术后肠梗阻的研究。 | |||
T13414 |
ZT 52656A hydrochloride
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
ZT 52656A hydrochloride 是一种 kappa 阿片样物质的选择性激动剂,用于预防或减轻眼部疼痛。 | |||
T4386 |
PZM21
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
PZM21 是一种有效的选择性 μ 阿片受体激动剂,EC50值为 1.8 nM。 | |||
T4407 |
SR17018
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
SR17018 是一种 μ-阿片受体 (MOR) 激动剂,与 GTPγS 结合,EC50 为 97 nM。 | |||
T8992 |
BMS986188
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
BMS986188 是一种新型的强效选择性正向变构调节剂,用于 δ-阿片受体。 | |||
T7218 |
Endomorphin 2
内吗啡肽 2 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Endomorphin 2 是一种高亲和力和选择性的 μ-阿片受体激动剂,对 kappa3 结合位点具有合理的亲和力 ,Ki 为 20 到 30 nM 之间。 | |||
T2071 |
MCOPPB triHydrochloride
MCOPPB trihydrochlride,MCOPPB 3HCl |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
MCOPPB triHydrochloride (MCOPPB 3HCl) 是一种伤害感受肽受体激动剂,pKi 为10.07。 | |||
TQ0267 |
Endomorphin 1
内吗啡肽 1,Endomorphin-1 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Endomorphin 1 是一种高亲和力和选择性的 μ-阿片受体激动剂,对 kappa3 结合位点具有合理的亲和力 ,Ki 为 20 到 30 nM 之间。 | |||
T5167 |
Cebranopadol
西博帕多,GRT6005 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Cebranopadol (GRT6005) 是镇痛 NOP 和阿片受体激动剂,对人 NOP、μ-阿片 (MOP)、κ-阿片 (KOP) 和 δ-阿片 (DOP) 受体的 Ki 值分别为 0.9、0.7、2.6 和 18 nM。 | |||
T1197 |
Trimebutine maleate
Debridat,Polibutin,马来酸曲美布汀 |
Calcium Channel; Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Trimebutine maleate (Polibutin) 是一种外周 μ、δ 和 kappa 阿片受体激动剂,用作治疗慢性和急性腹痛的解痉药物。 | |||
TQ0091 |
LY2795050
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
LY2795050 是一种新型特异性 κ-阿片受体拮抗剂,IC50为0.72 nM。 | |||
TP1905 |
BW-180C
(D-丙2,D-亮5)-脑啡肽,DADLE |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
BW-180C (DADLE) 是水溶性的多肽类δ-阿片受体激动剂,也对 μ-阿片受体显示活性,在体内表现出镇痛活性。 | |||
T6414 |
Bisacodyl
比沙可啶,Fenilaxan,Dulcolax,Brocalax |
Others | Others |
Bisacodyl (Fenilaxan) 是刺激性缓泻剂,可直接作用于结肠以产生排便。它能够直接激活结肠巨噬细胞来增加 PGE2的分泌。PGE2充当旁分泌因子并减少结肠中 AQP3 的表达,抑制水从腔向血管一侧的转移,进而产生通便作用。 | |||
T26869 |
BMS-986122
BMS 986122 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
BMS-986122 (BMS 986122) 是选择性 μ 阿片受体正变构调节剂,可增加 β-抑制蛋白募集、腺苷酸环化酶抑制和 G 蛋白活化的作用,还增强 DAMGO 介导的 [35S]GTPγS 在小鼠脑膜中的结合。 | |||
TP1367 |
[D-Ala2]leucine-enkephalin
(D-ALA2)-亮氨酸脑啡肽 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
[D-Ala2]leucine-enkephalin 是 δ 阿片类激动剂,是能长效抗降解的亮氨酸脑非肽,可用于研究 δ 阿片受体的信号通路。 | |||
TQ0082 |
Aticaprant
LY-2456302,CERC-501 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Aticaprant (LY-2456302) 是一种有效的中枢渗透性 kappa-阿片受体拮抗剂,Ki 值为 0.807 nM。 | |||
T14551 |
Bevenopran
CB-5945,ADL-5945 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Bevenopran (CB-5945) is a peripheral antagonist of μ-opioid receptor and can be used in studies about the treatment of opioid-induced bowel dysfunction. | |||
T15799 |
LY2940094
LY-2940094 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
LY2940094 (LY-2940094) 是一种口服有效的选择性 NOP 受体拮抗剂,可降低动物模型的自身给药酒精依赖,对 NOP 受体具有高亲和力,Ki 为 0.105 nM,和拮抗活力,Kb 为 0.166 nM。 | |||
T3996 |
Dapiprazole Hydrochloride
盐酸达哌唑,Glamidolo Hydrochloride,Reversil Hydrochloride |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Dapiprazole Hydrochloride (Glamidolo Hydrochloride) 是 α-adrenergic 阻断剂的药物。 | |||
T6175 |
ADL-5859
ADL5859 Hydrochloride,ADL5859 HCl |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
ADL-5859 (ADL5859 Hydrochloride) 是δ-阿片受体选择性激动剂,Ki 为0.8 nM,对阿片受体 κ 和 μ 具有选择性。 | |||
T14835 |
BTRX-335140
CYM-53093 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
BTRX-335140 (CYM-53093) 是一种有效的选择性口服活性 κ 阿片受体 (KOR) 拮抗剂,对 κOR、μOR 和 δOR 具有拮抗活性,IC50 值分别为 0.8、110 和 6500 nM。它可以很好地分布到 CNS 中,在大鼠中具有良好的体外吸收、分布、代谢、排泄和毒性以及体内药代动力学特征。 | |||
T7637 |
Deltorphin I
Deltorphin 1,Deltorphin I(TFA),Deltorphin C |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Deltorphin I 是 δ-阿片受体的激动剂。 | |||
T7639 |
Deltorphin 2
Deltorphin 2(TFA),[D-Ala2]-Deltorphin II |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Deltorphin 2 ([D-Ala2]-Deltorphin II) 是一种选择性的 δ 阿片受体肽激动剂,IC50 为 1 nM。 | |||
T9833 |
Opiranserin hydrochloride
|
P2X Receptor; GlyT; 5-HT Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Opiranserin hydrochloride 是甘氨酸转运蛋白 2 型 (GlyT2) 和 5-羟色胺受体 2A (5HT2A) 的双重拮抗剂,IC50 分别为 0.86 和 1.3 μM。它显示对 rP2X3 的拮抗活性 (IC50=0.87 μM)。它正在开发为用于治疗术后疼痛的注射剂。 | |||
T5158 |
N-Desmethylclozapine
N-去甲基氯氮平,Desmethylclozapine,Normethylclozapine,Norclozapine |
Virus Protease; Dopamine Receptor; 5-HT Receptor; Opioid Receptor; AChR; Drug Metabolite | Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
N-Desmethylclozapine (Desmethylclozapine) 是非典型抗精神病药 Clozapine 的主要活性代谢产物。它是血清素受体亚型 5-HT2C 的拮抗剂,IC50值为7.1 nM。 它也是多巴胺 D4 受体的拮抗剂和δ-阿片受体的激动剂。 | |||
T4633 |
Asimadoline
EMD-61753,阿西马朵林 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Asimadoline (EMD-61753) 是一种 κ-阿片(κ-opioid)受体激动剂,对豚鼠和人重组 κ-opioid 的IC50值分别为 5.6 和 1.2 nM。它可改善糖尿病大鼠的异常性疼痛,具有外周抗炎作用,并有用于肠易激综合征的研究潜力。 | |||
TP2036L |
DPDPE TFA (88373-73-3 free base)
DPDPE TFA |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
DPDPE TFA 是选择性 δ-阿片受体激动剂肽,在体内具有镇痛作用。 | |||
T7404 |
Dermorphin
皮啡肽 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Dermorphin 是在两栖类皮肤中发现的天然七肽,是 μ-阿片受体激动剂,可用于抑制神经痛。 | |||
T7211 |
Tyr-Gly-Gly-Phe-Met-OH
Methionine enkephalin,蛋氨酸脑啡肽,Met-Enkephalin,[MET5]脑啡肽 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin) 是天然存在的内源性阿片肽、metenkephalin 和 zeta-和 delta-阿片受体激动剂的合成形式,是 mu-阿片受体激动剂,具有潜在的镇痛、神经调节、免疫调节、抗炎、抗肿瘤作用以及镇痛、抗抑郁和胃肠运动调节活性。 | |||
T7173 |
[Leu5]-Enkephalin
亮氨酸脑啡肽,Leucine enkephalin,Leucyl-enkephalin,Leu-enkephalin |
Opioid Receptor; Endogenous Metabolite | Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience |
[Leu5]-Enkephalin (Leu-enkephalin) 是一种参与伤害感受的内源性神经肽,是 δ-阿片和 μ-阿片受体的激动剂,Ki 值分别为 4.0 和 3.4 nM | |||
T6504 |
Flupirtine maleate
Katadolon maleate,氟吡啶马来酸,马来酸氟吡汀 |
Potassium Channel; NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Flupirtine maleate (Katadolon maleate) 是可透过血脑屏障的、具有口服活性的非阿片类化合物。它是间接 NMDAR 拮抗剂,可用于缓解疼痛的研究,具有神经保护特性。 | |||
T21422 |
Methylnaltrexone bromide
Relistor,MOA-728,MOA 728,Methylnaltrexone,溴化甲基纳曲酮,MOA728 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Methylnaltrexone bromide (MOA-728) 是纳曲酮的四元衍生物,是可口服的外周作用 μ 阿片拮抗剂。它穿越血脑屏障的能力有限,可在胃肠道组织中发挥作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6S1010 |
Allomatrine
槐定碱,别苦参碱 |
Others | Others |
Allomatrine 是一种来源槐花树皮的生物碱。它能够激活 κ-阿片受体,进而产生缓解疼痛的作用。 | |||
T5S0581 |
Sec-O-Glucosylhamaudol
亥茅酚苷,Hamaudol 3-glucoside |
Others; Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience; Others |
Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) 是从滨海前胡中分离得到的一种天然产物,能够降低 μ 阿片受体的蛋白水平,可用于缓解疼痛的研究。它通过调节脂多糖刺激的 RAW264.7 细胞系中的 p38 丝裂原活化蛋白激酶具有抗炎作用。 | |||
T2726 |
Sinomenine
Cucoline,Kukoline,青藤碱 |
Apoptosis; Others; NF-κB; Opioid Receptor; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience; NF-κB; Others |
Sinomenine (Kukoline) 是来自汉防己的一种生物碱,是 μ 阿片受体激活剂,也是NF-κB 活化的阻断剂。 | |||
T5S2360 |
Corydaline
Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline |
P450; Virus Protease; Opioid Receptor; AChE | Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Corydaline (Corydalin) 是从 Corydalis yanhusuo 提取的一种异喹啉生物碱,是一种新型促动力植物药的主要活性成分之一。它促进胃排空和小肠转运,促进胃的调节,具有抗乙酰胆碱酯酶、抗过敏和镇痛活性。 | |||
T2921 |
Sinomenine hydrochloride
盐酸青藤碱,Sabianine A hydrochloride,Cucoline hydrochloride,Kukoline hydrochloride |
Apoptosis; NF-κB; Opioid Receptor; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience; NF-κB |
Sinomenine hydrochloride (Kukoline hydrochloride) 是来自汉防己的一种生物碱,是NF-κB 活化的阻断剂。Sinomenine 也是一种 μ 阿片受体激活剂。 | |||
T2870 |
Matrine
Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine |
Mitophagy; Ferroptosis; Opioid Receptor; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Matrine (Vegard) 是一种从槐属植物中分离出来的生物碱,可作为一种κ阿片受体激动剂,有抗肿瘤活性。 | |||
T2S2362 |
Dehydrocorydaline nitrate
去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱 |
BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome |
Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达,激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌、抗疟疾等功效。 | |||
TN1308 |
6-Hydroxyflavanone
|
Others; Lipoxygenase; COX; GABA Receptor | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others |
6-Hydroxyflavanone 是从菖蒲叶中提取分离,通过靶向环氧合酶-2(COX-2),5-脂氧合酶(5-LOX)以及阿片类药物和 GABA-A 受体从而具有抗炎和抗神经性疼痛活性。6-Hydroxyflavanone 在链脲佐菌素诱导的糖尿病神经病变模型中具有抗伤害感受特性。 | |||
T5S0754 |
Isoquercetin
3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷 |
NF-κB; Wnt/beta-catenin; NO Synthase | Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; Stem Cells |
Isoquercetin (3-Glucosylquercetin) 是天然存在的多酚,具有抗氧化,抗增殖和抗炎特性。它通过调节核因子-κB 转录调节系统调节一氧化氮合酶 2 的表达。它通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性,氧化应激和炎症反应。它具有高生物利用度和低毒性,是预防糖尿病妊娠出生缺陷的有希望的候选药物。 | |||
T3417 |
Amentoflavone
Didemethyl-ginkgetin,穗花杉双黄酮,Amenthoflavone,3',8''-Biapigenin |
Apoptosis; P450; Phospholipase; Reactive Oxygen Species; Opioid Receptor; COX; Antibacterial; RSV; Antifungal | Apoptosis; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB |
Amentoflavone (3',8''-Biapigenin) 是一种具有很多生物活性的双黄酮类天然产物,有抗炎、抗氧化和神经保护等作用。 | |||
T27534 |
Herkinorin
BF3DNCA methyl ester |
Others | Others |
Herkinorin is an opioid analgesic and an analogue of the natural product Salvinorin A. herkinorin is a μ-opioid agonist with more than 100x higher μ-opioid affinity and 50x lower κ-opioid affinity compared to Salvinorin A. Herkinorin is a semi-synthetic c | |||
TN3367 |
Akuammidine
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Akuammidine shows anti-inflammatory and anti-asthmatic properties, it has opioid analgesic activity, it shows a preference for mu-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 microM at mu-, delta- and kappa-opioid binding sites, respectively. | |||
T76027 |
β-Endorphin, equine TFA
|
Others | Others |
β-Endorphin, equine TFA,是具备强效亲和力于μ和δ阿片受体(μ/δ opioid receptors)的内源性阿片类多肽,主要功能包括止痛。 | |||
TN1890 |
Lupeol acetate
|
Others; TNF; NOS | Apoptosis; Immunology/Inflammation; Others |
Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the complete blockade of the opioid antagonist naloxone. | |||
T13433 |
β-Endorphin, human
|
Others | Others |
β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus,and is an agonist of opioid receptor. | |||
TN3368 |
Akuammigine
|
Opioid Receptor; Adrenergic Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Akuammigine has in vitro antimalarial activity. Akuammigine competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptors, yielding pA2 values of 4.68. Akuammidine also shows a preference for mu-opioid binding sites with Ki val | |||
TN4613 |
(-)-N-methylcoclaurine
N-Methylcoclaurine |
Others | Others |
N-Methylcoclaurine shows binding affinities for the ĸ opioid receptor with the equilibrium dissociation constant (Ki) value of 0.9 ± 0.1 uM. N-methylcoclaurine also shows promising butyrylcholinesterase inhibition activities, with the IC50 value of 1 | |||
T83913 |
Mitraciliatine
|
Others | Others |
Mitraciliatine是一种在M. speciosa(泰国称为Kratom)中发现的生物碱,是μ-阿片受体(MOR)部分激动剂和κ-阿片受体(KOR)激动剂。该化合物对MOR和KOR具有选择性,与δ-阿片受体(DOR; EC50s分别为228, 218, 和 >1,000 nM,针对小鼠受体在GTPγS结合实验中的表现)。Mitraciliatine(100 nmol/动物,脑室内注射)在小鼠的热水尾部缩回实验中延长了撤回潜伏期,这一效果可以通过敲除MOR而非KOR来逆转。与吗啡不同,Mitraciliatine不会诱发过度活动或呼吸抑制。 | |||
TN4064 |
Flavoglaucin
|
Phosphatase; IL Receptor; TNF; NOS; NF-κB; COX; Nrf2; Prostaglandin Receptor; Autophagy | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB |
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin appears to be an antitumor promoter, it also has anti-inflammato |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01719 |
OPRM1 Protein, Human, Recombinant (His)
Mu opioid receptor,OPRM1,Mu opiate receptor,Mu-type... |
Human | E. coli |
OPRM1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 47.6 kDa and the accession number is P35372. | |||
TMPY-04733 |
OPCML Protein, Rat, Recombinant (hFc)
opioid binding protein/cell adhesion molecule-like |
Rat | HEK293 Cells |
OPCML Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 59 kDa and the accession number is P32736-1. | |||
TMPY-00893 |
OPCML Protein, Human, Recombinant (His)
OPCM,IGLON1,OBCAM,opioid binding protein/cell adhes... |
Human | HEK293 Cells |
OPCML Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34 kDa and the accession number is A8K0Y0. | |||
TMPY-03818 |
OPCML Protein, Mouse, Recombinant (His)
opioid binding protein/cell adhesion molecule-like,... |
Mouse | HEK293 Cells |
OPCML Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.7 kDa and the accession number is Q6DFY2. | |||
TMPJ-00737 |
PDYN Protein, Human, Recombinant (His)
PDYN,ADCA,Big Dyn,Dynorphin B,PENKB,SCA23 |
Human | HEK293 Cells |
Proenkephalin-B(PDYN), belongs to the opioid neuropeptide precursor family. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. Leu-enkephalins, which is a type of Proenkephalin-B, compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A has a typical o... | |||
TMPH-02020 |
RGS17 Protein, Human, Recombinant (GST)
Regulator of G-protein signaling 17,RGS17 |
Human | E. coli |
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. R... | |||
TMPY-04121 |
NAGA Protein, Human, Recombinant (His)
D22S674,N-acetylgalactosaminidase, α-,N-acetylgalactosaminid... |
Human | HEK293 Cells |
NAGA (Alpha-N-Acetylgalactosaminidase) is a Protein Coding gene. NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. It belongs to the glycosyl hydrolase 27 family. The antinociceptive effect of NAGA may involve the participation of endogenous opioid peptides and endogenous catecholamines. Normal alpha-NAGA is synthesized as a 52 kDa precursor which matures to a 49 kDa species through phosphorylation and car... | |||
TMPJ-00513 |
LTF Protein, Human, Recombinant (His)
Lactoferroxin-A,Talalactoferrin,LTF,Lactotransferrin,Lactofe... |
Human | HEK293 Cells |
Lactotransferrin is a member of the transferrin family that transfer iron to the cells and control the level of free iron in the blood and external secretions. Lactotransferrin is a secreted protein and contains two transferrin-like domains. Lactotransferrin can be cleaved into the following four chains: Kaliocin-1, Lactoferroxin-A, Lactoferroxin-B, and Lactoferroxin-C. Lactoferroxin A, Lactoferroxin B, and Lactoferroxin C have opioid antagonist activity. Lactoferroxin A shows preference for mu-... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11867 |
Loperamide-d6 hydrochloride
R-18553 D6 hydrochloride |
Others | Others |
Loperamide D6 hydrochloride, a deuterium-labeled variant of Loperamide hydrochloride, acts as an opioid receptor agonist utilized for diarrhea treatment. | |||
T10181 |
6-beta-Naloxol D5 hydrochloride
6β-Naloxol D5 hydrochloride |
Others | Others |
6-beta-Naloxol D5 hydrochloride is a deuterium-labeled opioid antagonist, closely related to naloxone, that serves as an effective compound in the field of chemical research. | |||
TMIJ-0213 |
Naloxone-d5 HCl
|
||
Naloxone-d5 HCl 是 Naloxone HCl 的氘代化合物。Naloxone HCl 的 CAS 号为 357-08-4。Naloxone hydrochloride 是一种特异性、没有激动剂活性的opiate拮抗剂。它是 mu、delta 和 kappa 阿片受体的竞争性拮抗剂。 |