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Search Results for " lactate "
Targets Recommended: VEGFR FGFR FLT PDGFR c-Kit

83

抑制剂 & 化合物

21

天然产物

2

化合物库

14

重组蛋白

2

同位素标记化合物

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Cat. No. Product Name
L2501 人内源代谢化合物库 Plus

1283 compounds
1283种内源性生物活性化合物的独特集合,用于高通量、高内涵筛选。
L2520 糖代谢化合物库

702 compounds
702 种糖代谢相关的化合物,可用于高通量和高内涵筛选;

化合物库

人内源代谢化合物库 Plus
Cat.No: L2501
Compounds: 1283
糖代谢化合物库
Cat.No: L2520
Compounds: 702
Cat. No. Product Name Target Signaling Pathways
T6479 Dovitinib lactate hydrate

Dovitinib (TKI258) Lactate,多韦替尼,Dovitinib Lactate,TKI258

VEGFR; FGFR; FLT; PDGFR; c-Kit Angiogenesis; Tyrosine Kinase/Adaptors
Dovitinib lactate hydrate (TKI258) 是一种多靶点的酪氨酸激酶抑制剂,抑制 FLT3,c-Kit,FGFR1/3,VEGFR1/2/3和 PDGFRα/β的 IC50值分别为 1,2,8/9,10/13/8,27/210 nM。
T7104 Dovitinib lactate

CHIR-258 lactate,多韦替尼乳酸盐,TKI-258 lactate

VEGFR; FGFR; FLT; PDGFR; c-Kit Angiogenesis; Tyrosine Kinase/Adaptors
Dovitinib lactate (TKI-258 lactate) 是一种多靶点的酪氨酸激酶抑制剂,抑制FLT3,c-Kit,FGFR1/3,VEGFR1/2/3和PDGFRα/β的IC50值分别为 1,2,8/9,10/13/8,27/210 nM。
T40923 Calcium lactate

Lactic acid calcium,Hemicalcium L-lactate,Lactate calcium,乳酸钙,Conclyte calcium

Others Others
Calcium lactate (Conclyte calcium) 被饮料工业用作强化果汁的钙源。Calcium lactate 促进豆芽生长和植酸降解。
T5967 Ethacridine lactate

乳酸依沙吖啶,Acrinol,6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE

Others; Antibacterial Microbiology/Virology; Others
Ethacridine lactate (Acrinol) 是一种聚 (ADP-核糖) 糖水解酶 (PARG) 抑制剂,也是一种抗菌剂和流产剂。它有抗金黄色葡萄球菌和其他革兰氏阳性球菌的活性。
T4103 (L)-Sodium lactate

L-乳酸钠,Sodium L-Lactate

Others Others
(L)-Sodium lactate (Sodium L-Lactate) 是由乳酸脱氢酶从丙酮酸中产生的。它在无氧糖酵解过程中或增殖活跃的细胞中产生。 它在人和动物的血液和肌肉液中少量存在。剧烈运动后,肌肉和血液中的乳酸浓度会增加。 它也存在于肝脏、肾脏、胸腺、人羊水以及其他器官和体液中。
T8785 HALOFUGINONE LACTATE

DNA/RNA Synthesis; TGF-beta/Smad Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Stem Cells
HALOFUGINONE LACTATE 是 febrifugine 的卤化衍生物,它是一种天然的含有喹唑啉酮的化合物,存在于中草药 D. febrifuga 中。Halofuginone 以 ATP 依赖性方式抑制脯氨酰-tRNA 合成酶,Ki 为 18.3 nM。 Halofuginone 是 I 型胶原合成的特异性抑制剂,通过抑制 TGF-β 活性来减轻骨关节炎 (OA)
T1440 Ethacridine lactate monohydrate

乳酸依沙吖啶一水物,利凡诺

Antibacterial; Antibiotic Microbiology/Virology
Ethacridine lactate monohydrate 是一种聚 (ADP-核糖) 糖基水解酶 (PARG) 抑制剂,有抗金黄色葡萄球菌和其他革兰氏阳性球菌的活性。它也是抗菌剂和流产剂。
T32809 L-Lactate ion

L-Lactate,Lactate ion, L-

Others Others
L-Lactate ion is the conjugate base of lactic acid.
T26300 Tylosin, lactate

lactate (1:1),Tylosin

Others Others
Tylosin, lactate is a bacteriostat feed additive used in veterinary medicine. It is a macrolide antibiotic that has a broad spectrum of activity against Gram-positive organisms but a limited range of Gram-negative organisms. It is found naturally as a fer
T12117 MSI-1436 lactate

Trodusquemine lactate,Aminosterol-1436 lactate

Others Others
MSI-1436 lactate is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM)
T28236 Onalespib lactate

AT-13387 lactate,ATI-13387AU,ATI-13387,ATI 13387,ATI-13387A

Others Others
Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.
T33057 Lysine lactate

Others Others
Lysine lactate is a bioactive chemical.
T68415 Tozasertib lactate

Others Others
Tozasertib lactate is a potent and selective small-molecule inhibitor of the Aurora kinases which suppresses tumor growth by inducing apoptosis in tumor cells in which Aurora kinases are overexpressed.
T30456 Biperiden lactate

Others Others
Biperiden lactate is a biochemical.
T39862 Trimethoprim lactate

Others Others
Trimethoprim lactic is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactic is active against a wide range of Gram-positive and Gram-negative aerobic bacteria . Trimethoprim lactic has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment.
T24659 Prenylamine lactate

Agozol,Angormin

Others Others
Prenylamine lactate is a drug formerly used in the treatment of angina pectoris. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity.
T30453 Bimethoxycaine lactate

U 0045,U-0045,NSC 9108,NSC9108,NSC-9108

Others Others
Bimethoxycaine lactate is a bioactive chemical.
T6702L Terbinafine lactate

DRG-0286,Terbinafine hydrochloride,Lamisil Krem,SF 86-327 hydrochloride,Lamisil,Lamisil AT

Others Others
Terbinafine, a synthetic allylamine antifungal, inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway.
T33054 Lysine DL-lactate

Others Others
Lysine DL-lactate is a bioactive chemical.
T20440 Benzyl lactate

AI3 15720,AI3-15720,AI315720

Others Others
Benzyl Lactate is an agent of biochemical.
T4310L Prexasertib lactate hydrate

Prexasertib monolactate monohydrate,LY-2606368,LY 2606368,LY2606368,Prexasertib monolactate monohydrate salt

Others Others
Prexasertib is an effective and selective Chk1/Chk2 inhibitor. Prexasertib causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms.
T62524 Panobinostat lactate

Others Others
Panobinostat lactate 是一种有效的、口服具有活力的、非选择性 HDAC 抑制剂,具有抗肿瘤作用。Panobinostat lactate 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。Panobinostat lactate 能够有效干扰 HIV 潜伏期。Panobinostat lactate 能够用于研究难治性或复发性多发性骨髓瘤。
T21151 AT-9283 L-lactate

AT-9283,AT 9283,AT9283

Others Others
AT-9283 L-lactate is an inhibitor of aurora kinase.
T78348 Lactate oxidase

Others Others
Lactate oxidase是一种FMN依赖性酶,能催化乳酸转化为丙酮酸并同时释放过氧化氢,常用于乳酸的检测。
T68672 Amsacrine lactate

Others Others
Amsacrine lactate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death.
T62975 Haloperidol lactate

Others Others
Haloperidol lactate 是一种有效的抗精神病药。Haloperidol lactate 具有潜力进行精神障碍的研究。Haloperidol lactate 能够用于急性和慢性精神分裂症和多发性秽语综合征。
T68742 Inamrinone lactate

Others Others
Inamrinone lactate is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
T64542 Lactate potassium

Others Others
Lactate potassium 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64542,CAS号为 996-31-6。
T81962 Lactate transportor 1

Monocarboxylate transporter Membrane transporter/Ion channel
Lactate transporter 1 (compound 1) 作为一种活性乳酸运输蛋白,主要在活细胞内发挥作用。在Hela、CAL27、MCF7和MCF10A细胞系中,Lactate transporter 1 均显示出了明显的毒性,其半抑制浓度(IC50)值依次为3.36、3.27、5.58和7.66 μM。此外,在HeLa细胞中,Lactate transporter 1 与Cisplatin表现出了协同抑制的作用。
T66299 Ciprofloxacin lactate

Others Others
Ciprofloxacin lactate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66299,CAS号为 97867-33-9。
T70625 Nicotine lactate

Others Others
Nicotine is a naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and Duboisia hopwoodii) and is widely used recreationally as a stimulant and anxiolytic. As a pharmaceutical drug, it is used for smoking cessation to relieve withdrawal symptoms. Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits (nAChRα9 and nAChRα10) where it acts as a receptor antagonist.
T76116 L-Lactate dehydrogenase

Others Others
L-Lactate dehydrogenase (L-乳酸脱氢酶) 是一种氧化还原酶。L-Lactate dehydrogenase 在体内催化 NADH 将丙酮酸还原为 L-乳酸。
T76146 D-Lactate dehydrogenase

Others Others
D-Lactate dehydrogenase(D-LDH)为一种氧化还原酶,以NAD+或NADP+作为受体,特异性作用于供体的CH-OH基团,催化D-乳酸氧化成丙酮酸。该酶主要分布于细菌和真菌中,是生化研究中常用的酶。
T15435 GSK2837808A

Dehydrogenase Metabolism
GSK2837808A 是一种选择性的乳酸脱氢酶A 抑制剂,对 hLDHA (IC50:2.6 nM) 和 hLDHB (IC50:43 nM)。
T11829 LDH-IN-1

Dehydrogenase Metabolism
LDH-IN-1 是新型的基于吡唑的人乳酸脱氢酶抑制剂,对于 LDHA 和 LDHB 的 IC50 分别为32和27 nM。
T22336 Galloflavin

Dehydrogenase Metabolism
Galloflavin 是乳酸脱氢酶抑制剂。用 Pyruvate 法得到的 Ki 为 5.46 µM (LDH-A) 以及15.06 µM (LDH-B)。它能够阻断 ATP 的生成和糖酵解,从而抑制癌细胞的增殖。
T1768 7ACC2

Mitochondrial Metabolism; Monocarboxylate transporter Membrane transporter/Ion channel; Metabolism
7ACC2 是单羧酸盐转运蛋白抑制剂,IC50为 11 nM。它还是线粒体丙酮酸转运的有效抑制剂,可抑制乳酸涌入,通过抑制乳酸通量来发挥抗癌作用。
T4295 (R)-GNE-140

GNE-140

Dehydrogenase Metabolism
(R)-GNE-140 (GNE-140) 是 LDHA 抑制剂,能够作用于 LDHA (IC50:3 nM) 和 LDHB (IC50:3 nM)。它的活性是 S 型异构体的 18 倍。
T11546 hDHODH-IN-1

Dehydrogenase Metabolism
hDHODH-IN-1 是有效的人二氢乳清酸脱氢酶抑制剂, 显示出抗炎作用。
T3105 PFK-158

Apoptosis; Glucokinase; Autophagy Apoptosis; Autophagy; Metabolism
PFK158 是一种选择性的PFKFB3抑制剂,IC50值为 137 nM。它可减少癌细胞中葡萄糖的摄取,ATP 的产生,乳酸的释放,并诱导细胞凋亡和自噬。它还可以增强 Colistin 对细菌的抵抗力,具有广泛的抗肿瘤活性。
T12438 PfDHODH-IN-1

Dehydrogenase; Parasite Metabolism; Microbiology/Virology
PfDHODH-IN-1 是 Leflunomide 活性代谢物的类似物,具有抗疟疾活性。它是恶性疟原虫二氢乳清酸脱氢酶抑制剂。
T7482 3-chloro-5-hydroxybenzoic Acid

GPR Endocrinology/Hormones; GPCR/G Protein
3-Chloro-5-hydroxybenzoic acid 是一种口服具有活力的乳酸受体GPR81选择性激动剂,对人 GPR81 的EC50为 16 μM。肥胖小鼠模型中,它表现出良好的体内脂肪分解作用。
T3175 LDHA-IN-4

AZ 33,AZ-33,LDHA Inhibitor,AZ33

Dehydrogenase Metabolism
LDHA-IN-4 (AZ33) 是乳酸脱氢酶 A 选择性抑制剂,IC50=0.5 μM,Kd=0.093 μM。
T5325 Nifurtimox

硝呋替莫,BAY-2502,BAY-A-2502

Dehydrogenase; Parasite Metabolism; Microbiology/Virology
Nifurtimox (BAY-A-2502) 是一种用于锥虫病的抗虫剂,可影响乳酸脱氢酶活性。它有潜力研究神经母细胞瘤细胞。
T0239 Lonidamine

AF1890,氯尼达明,DICA,Diclondazolic Acid

Apoptosis; Hexokinase; Mitochondrial Metabolism Apoptosis; Metabolism
Lonidamine (Diclondazolic Acid) 是一种抗肿瘤药物,是己糖激酶、线粒体丙酮酸载体和质膜单羧酸转运蛋白抑制剂,同时也抑制线粒体复合物 II。
T7460 α-Cyano-4-hydroxycinnamic acid

α-Cyano-4-hydroxycinnamic acid(α-CHCA),2-氰基-4-羟基

Monocarboxylate transporter Membrane transporter/Ion channel
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) 是非竞争性单羧酸盐转运蛋白 (MCTs) 抑制剂,可抑制线粒体丙酮酸转运蛋白,Ki 值为 6.3 μM。它可作为基质辅助激光解吸电离-飞行时间质谱 (MALDI-TOF) 分析的基质,可以促进肽离子化。
T72324 Lagociclovir valactate

Others Others
Lagociclovir valactate 是 Lagociclovir 的前药。Lagociclovir valactate 是一种具有口服活性的抗HBV 试剂。
T60165 VB124

Monocarboxylate transporter Membrane transporter/Ion channel
VB124 是一种具有口服活性的、有效且选择性的MCT4抑制剂。VB124 可特异性抑制 MDA-MB-231 细胞中乳酸的涌入和流出,IC50分别为 8.6 nM 和 19 nM。VB124 对 MCT4 的选择性高于 MCT1。VB124可用于心脏肥大、心力衰竭和代谢的研究。
T5845 7ACC1

DEAC,香豆素D1421,Coumarin D 1421,7-(二乙胺基)-2-氧代-2-苯并吡喃-3-羧酸,7-(Diethylamino)coumarin-3-carboxylic acid,D 1421

Monocarboxylate transporter Membrane transporter/Ion channel
7ACC1 (D 142) 抑制表达MCT1和MCT4肿瘤细胞的乳酸涌入,能选择性干扰肿瘤微环境乳酸通量。
T64345 4-(Dimethylamino)phenol

Others Others
4-(Dimethylamino)phenol enhances extracellular lactate dehydrogenase (LDH) levels without significant effects on gluconeogenesis. Only when the membrane becomes permeable to LDH does 4-(Dimethylamino)phenol reduce ATP content.

化合物

Dovitinib lactate hydrate
Cat.No: T6479
Synonym: Dovitinib (TKI258) Lactate,多韦替尼,Dovitinib Lactate,TKI258
Target: VEGFR, FGFR, FLT, PDGFR, c-Kit
Dovitinib lactate
Cat.No: T7104
Synonym: CHIR-258 lactate,多韦替尼乳酸盐,TKI-258 lactate
Target: VEGFR, FGFR, FLT, PDGFR, c-Kit
Calcium lactate
Cat.No: T40923
Synonym: Lactic acid calcium,Hemicalcium L-lactate,Lactate calcium,乳酸钙,Conclyte calcium
Target: Others
Ethacridine lactate
Cat.No: T5967
Synonym: 乳酸依沙吖啶,Acrinol,6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE
Target: Others, Antibacterial
(L)-Sodium lactate
Cat.No: T4103
Synonym: L-乳酸钠,Sodium L-Lactate
Target: Others
HALOFUGINONE LACTATE
Cat.No: T8785
Synonym:
Target: DNA/RNA Synthesis, TGF-beta/Smad
Ethacridine lactate monohydrate
Cat.No: T1440
Synonym: 乳酸依沙吖啶一水物,利凡诺
Target: Antibacterial, Antibiotic
L-Lactate ion
Cat.No: T32809
Synonym: L-Lactate,Lactate ion, L-
Target: Others
Tylosin, lactate
Cat.No: T26300
Synonym: lactate (1:1),Tylosin
Target: Others
MSI-1436 lactate
Cat.No: T12117
Synonym: Trodusquemine lactate,Aminosterol-1436 lactate
Target: Others
Onalespib lactate
Cat.No: T28236
Synonym: AT-13387 lactate,ATI-13387AU,ATI-13387,ATI 13387,ATI-13387A
Target: Others
Lysine lactate
Cat.No: T33057
Synonym:
Target: Others
Tozasertib lactate
Cat.No: T68415
Synonym:
Target: Others
Biperiden lactate
Cat.No: T30456
Synonym:
Target: Others
Trimethoprim lactate
Cat.No: T39862
Synonym:
Target: Others
Prenylamine lactate
Cat.No: T24659
Synonym: Agozol,Angormin
Target: Others
Bimethoxycaine lactate
Cat.No: T30453
Synonym: U 0045,U-0045,NSC 9108,NSC9108,NSC-9108
Target: Others
Terbinafine lactate
Cat.No: T6702L
Synonym: DRG-0286,Terbinafine hydrochloride,Lamisil Krem,SF 86-327 hydrochloride,Lamisil,Lamisil AT
Target: Others
Lysine DL-lactate
Cat.No: T33054
Synonym:
Target: Others
Benzyl lactate
Cat.No: T20440
Synonym: AI3 15720,AI3-15720,AI315720
Target: Others
Prexasertib lactate hydrate
Cat.No: T4310L
Synonym: Prexasertib monolactate monohydrate,LY-2606368,LY 2606368,LY2606368,Prexasertib monolactate monohydrate salt
Target: Others
Panobinostat lactate
Cat.No: T62524
Synonym:
Target: Others
AT-9283 L-lactate
Cat.No: T21151
Synonym: AT-9283,AT 9283,AT9283
Target: Others
Lactate oxidase
Cat.No: T78348
Synonym:
Target: Others
Amsacrine lactate
Cat.No: T68672
Synonym:
Target: Others
Haloperidol lactate
Cat.No: T62975
Synonym:
Target: Others
Inamrinone lactate
Cat.No: T68742
Synonym:
Target: Others
Lactate potassium
Cat.No: T64542
Synonym:
Target: Others
Lactate transportor 1
Cat.No: T81962
Synonym:
Target: Monocarboxylate transporter
Ciprofloxacin lactate
Cat.No: T66299
Synonym:
Target: Others
Nicotine lactate
Cat.No: T70625
Synonym:
Target: Others
L-Lactate dehydrogenase
Cat.No: T76116
Synonym:
Target: Others
D-Lactate dehydrogenase
Cat.No: T76146
Synonym:
Target: Others
GSK2837808A
Cat.No: T15435
Synonym:
Target: Dehydrogenase
LDH-IN-1
Cat.No: T11829
Synonym:
Target: Dehydrogenase
Galloflavin
Cat.No: T22336
Synonym:
Target: Dehydrogenase
7ACC2
Cat.No: T1768
Synonym:
Target: Mitochondrial Metabolism, Monocarboxylate transporter
(R)-GNE-140
Cat.No: T4295
Synonym: GNE-140
Target: Dehydrogenase
hDHODH-IN-1
Cat.No: T11546
Synonym:
Target: Dehydrogenase
PFK-158
Cat.No: T3105
Synonym:
Target: Apoptosis, Glucokinase, Autophagy
PfDHODH-IN-1
Cat.No: T12438
Synonym:
Target: Dehydrogenase, Parasite
3-chloro-5-hydroxybenzoic Acid
Cat.No: T7482
Synonym:
Target: GPR
LDHA-IN-4
Cat.No: T3175
Synonym: AZ 33,AZ-33,LDHA Inhibitor,AZ33
Target: Dehydrogenase
Nifurtimox
Cat.No: T5325
Synonym: 硝呋替莫,BAY-2502,BAY-A-2502
Target: Dehydrogenase, Parasite
Lonidamine
Cat.No: T0239
Synonym: AF1890,氯尼达明,DICA,Diclondazolic Acid
Target: Apoptosis, Hexokinase, Mitochondrial Metabolism
α-Cyano-4-hydroxycinnamic acid
Cat.No: T7460
Synonym: α-Cyano-4-hydroxycinnamic acid(α-CHCA),2-氰基-4-羟基
Target: Monocarboxylate transporter
Lagociclovir valactate
Cat.No: T72324
Synonym:
Target: Others
VB124
Cat.No: T60165
Synonym:
Target: Monocarboxylate transporter
7ACC1
Cat.No: T5845
Synonym: DEAC,香豆素D1421,Coumarin D 1421,7-(二乙胺基)-2-氧代-2-苯并吡喃-3-羧酸,7-(Diethylamino)coumarin-3-carboxylic acid,D 1421
Target: Monocarboxylate transporter
4-(Dimethylamino)phenol
Cat.No: T64345
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T5220 D-(-)-Lactic acid sodium

Sodium D-lactate,D-乳酸钠

Others; Endogenous Metabolite Metabolism; Others
D-(-)-Lactic acid sodium (Sodium D-lactate) 是一种有机酸。它是一种手性分子,由 L-乳酸和 D-乳酸两种光学异构体组成,其中 L-异构体在生物体中最常见。D-(-)-Lactic acid sodium 也是一种微生物代谢产物。
T20574 Magnesium lactate

Bis(lactato)magnesium

Magnesium lactate is a magnesium donor and buffering agent.
T12996 Squalamine lactate

MSI-1256F

Others Others
Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity.
T5705 Glomeratose A

Dehydrogenase Metabolism
Glomeratose A 是分离自远志Polygala tenuifolia 中,是一种乳酸脱氢酶lactate dehydrogenase 抑制剂。
TN2252 Syrosingopine

Dopamine Receptor GPCR/G Protein; Neuroscience
Syrosingopine 是 MCT1和 MCT4双重抑制剂,对 MCT4 的效力高 60 倍,可防止乳酸和 H+ 流出。它是可口服抗高血压药物,联合二甲双胍具有研究癌症疾病的潜力。
T7964 Isomalt

异麦芽酮糖醇,Palatinitol,Palatinit

Others; Dehydrogenase Metabolism; Others
Isomalt (Palatinitol) 是无毒的、具有良好耐受性的多元醇和蛋白质稳定的赋形剂,在冷冻干燥过程中可适度稳定乳酸脱氢酶(LDH),并在储存期间表现更好。它传统上在食品工业中用作甜味剂,也在制药中用作压片赋形剂。
T5S0620 3-Dehydrotrametenolic acid

Dehydrotrametenolic acid,松苓新酸,3-氢化去氢松苓酸

Apoptosis; Others; Dehydrogenase Apoptosis; Metabolism; Others
3-Dehydrotrametenolic acid 是从茯苓菌核分离的一种乳酸脱氢酶抑制剂,可诱导细胞凋亡,具有抗癌活性。它促进体外脂肪细胞分化,在体内起胰岛素增敏剂的作用。
TN4021 Ethyl p-hydroxyphenyllactate

Others Others
Ethyl p-hydroxyphenyllactate是一种天然产物,属于菊科还羊参属,其产品编号为 TN4021,CAS号为 62517-34-4。Ethyl p-hydroxyphenyllactate可用作对照参考。
TN4552 Methyl p-hydroxyphenyllactate

Others Others
Methyl para-hydroxyphenyllactate(MeHPLA) can suppress the cellular proliferation of estrogen-sensitive MCF-7 breast cancer cells in vitro and to suppress the growth of rat uteri in vivo, high affinity of MeHPLA for the type II estrogen binding site (EBS)
TN1829 Kakkalide

Dehydrogenase Metabolism
Kakkalide 是提取自葛根花中的一种异黄酮。它可以抑制活性氧相关炎症,并改善内皮细胞胰岛素抵抗作用。
T5S2195 Sibiricose A5

西伯利亚远志糖A5

Dehydrogenase Metabolism
Sibiricose A5 是一种寡糖酯,分离自Polygalae Radix,具有抗氧化作用。
T2S2211 Tenuifoliside C

Dehydrogenase Metabolism
Tenuifoliside C 是从野生的 polygala tenuifolia 中分离得到的。它对 CYP2E1 催化氯唑酮 6-羟基化反应具有抑制作用。
T4738 Sodium 2-hydroxybutanoate

2-Hydroxybutyric acid sodium salt,2-羟基丁酸钠,DL-2-Hydroxybutyric Acid Sodium Salt,alpha-hydroxybutyrate,SODIUM 2-HYDROXYBUTYRATE

Others; Endogenous Metabolite Metabolism; Others
Sodium 2-hydroxybutanoate (alpha-hydroxybutyrate) 是内源性代谢产物的一种。
TN1769 Iristectorin A

Dehydrogenase Metabolism
Iristectorin A 是从 Iris tectorum Maxim 中提取出来的异黄酮化合物,是一种乳酸脱氢酶抑制剂,可用于研究癌症。
T5702 Tenuifoliside B

Dehydrogenase Metabolism
Tenuifoliside B 是一种分离自Polygalae Radix 中的成分,能够抑制氰化钾引起的缺氧和东莨菪碱引起的记忆障碍。它有成为 AD 先导化合物的潜力。它具有潜在的认知改善和脑保护作用。
TN1182 11-​Keto-​beta-​boswellic acid

11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸

Leukotriene Receptor; NF-κB; Lipoxygenase GPCR/G Protein; Metabolism; NF-κB
11-Keto-beta-boswellic acid 是来自乳香的一种五环三萜酸,具有抗炎活性和剂量依赖性心脏保护作用,主要是由于抑制5-脂氧合酶、白三烯、NF-κB 的激活和肿瘤坏死因子 α 的产生。
TN1013 Cucurbitacin D

Apoptosis Apoptosis
Cucurbitacin D 是一种从 Ecballium elaterium (L.)分离出来的三萜类化合物,具有抗癌抗肿瘤活性,抑制转移性 PrC 中的葡萄糖摄取和乳酸产生,诱导独立于 ERK1/2 激活的炎症小体激活。 Cucurbitacin D 是巨噬细胞中的一种新的炎症小体激活剂,通过调节 JAK/STAT3、PI3K/Akt/mTOR 和 MAPK 信号通路抑制 HepG2 细胞增殖并诱导细胞凋亡, 可用于研究宫颈癌、白血病和前列腺癌。
T5290 (S)-2-Hydroxy-3-phenylpropanoic acid

L-(−)-3-Phenyllactic acid,L-3-苯乳酸

Others; Endogenous Metabolite Metabolism; Others
(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) 是苯丙氨酸的代谢产物。苯丙酮尿症患者体液中苯丙氨酸的水平升高。
TN6945 Lactic acid

2-hydroxypropanoic acid

Others Others
Lactic acid (2-hydroxypropanoic acid) 是糖酵解的产物,广泛存在与自然界中。Lactate acid 在体内收缩骨骼肌缺氧时会产生,可在完全有氧条件下被去除。Lactic acid 可作为危重病人的血流动力学指标。Lactic acid 具有抗肿瘤活性。
T13922 Thevetiaflavone

2-Genistein-5-methyl ether,Apigenin-5-methyl ether

BCL; Caspase Apoptosis; Proteases/Proteasome
Thevetiaflavone (2-Genistein-5-methyl ether) 是一种来自 Wikstroemia indica 的天然类黄酮,可抑制乳酸脱氢酶从细胞质中泄漏并提高细胞活力。
T83725 Nigerose

Sakebiose

Others Others
Nigerose,一种在Acremonium中发现的二糖,当与苷类化合物salidroside联合使用,浓度为150 µM时,可阻止HL-60细胞冷冻保存后的丙二醛(MDA)和活性氧物质(ROS)水平上升,并抑制乳酸脱氢酶(LDH)的释放。

天然产物

D-(-)-Lactic acid sodium
Cat.No: T5220
Synonym: Sodium D-lactate,D-乳酸钠
Target: Others, Endogenous Metabolite
Magnesium lactate
Cat.No: T20574
Synonym: Bis(lactato)magnesium
Target:
Squalamine lactate
Cat.No: T12996
Synonym: MSI-1256F
Target: Others
Glomeratose A
Cat.No: T5705
Synonym:
Target: Dehydrogenase
Syrosingopine
Cat.No: TN2252
Synonym:
Target: Dopamine Receptor
Isomalt
Cat.No: T7964
Synonym: 异麦芽酮糖醇,Palatinitol,Palatinit
Target: Others, Dehydrogenase
3-Dehydrotrametenolic acid
Cat.No: T5S0620
Synonym: Dehydrotrametenolic acid,松苓新酸,3-氢化去氢松苓酸
Target: Apoptosis, Others, Dehydrogenase
Ethyl p-hydroxyphenyllactate
Cat.No: TN4021
Synonym:
Target: Others
Methyl p-hydroxyphenyllactate
Cat.No: TN4552
Synonym:
Target: Others
Kakkalide
Cat.No: TN1829
Synonym:
Target: Dehydrogenase
Sibiricose A5
Cat.No: T5S2195
Synonym: 西伯利亚远志糖A5
Target: Dehydrogenase
Tenuifoliside C
Cat.No: T2S2211
Synonym:
Target: Dehydrogenase
Sodium 2-hydroxybutanoate
Cat.No: T4738
Synonym: 2-Hydroxybutyric acid sodium salt,2-羟基丁酸钠,DL-2-Hydroxybutyric Acid Sodium Salt,alpha-hydroxybutyrate,SODIUM 2-HYDROXYBUTYRATE
Target: Others, Endogenous Metabolite
Iristectorin A
Cat.No: TN1769
Synonym:
Target: Dehydrogenase
Tenuifoliside B
Cat.No: T5702
Synonym:
Target: Dehydrogenase
11-​Keto-​beta-​boswellic acid
Cat.No: TN1182
Synonym: 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸
Target: Leukotriene Receptor, NF-κB, Lipoxygenase
Cucurbitacin D
Cat.No: TN1013
Synonym:
Target: Apoptosis
(S)-2-Hydroxy-3-phenylpropanoic acid
Cat.No: T5290
Synonym: L-(−)-3-Phenyllactic acid,L-3-苯乳酸
Target: Others, Endogenous Metabolite
Lactic acid
Cat.No: TN6945
Synonym: 2-hydroxypropanoic acid
Target: Others
Thevetiaflavone
Cat.No: T13922
Synonym: 2-Genistein-5-methyl ether,Apigenin-5-methyl ether
Target: BCL, Caspase
Nigerose
Cat.No: T83725
Synonym: Sakebiose
Target: Others
Cat. No. Product Name Species Expression System
TMPY-04180 PfLDH Protein, P. falciparum, Recombinant (His)

PfLDH,L-lactate dehydrogenase

P. falciparum E. coli
Plasmodium falciparum lactate dehydrogenase (PfLDH) is a key enzyme for energy generation of malarial parasites and is considered to be a potential antimalarial target. The ability of PfLDH- or PfIDEh-based immuno-PCR assays to detect <1 parasite/microL suggests that improvements of bound antibody sensor technology may greatly increase the sensitivity of malaria rapid diagnostic tests. The PfLDH test could be used to detect failures and, therefore, to assess anti-malarial efficacy.
TMPH-00693 L-lactate dehydrogenase Protein, E. coli O9:H4, Recombinant (His)

lldD,L-lactate dehydrogenase

E. coli E. coli
Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.
TMPH-03136 L-lactate dehydrogenase Protein, Plasmodium berghei, Recombinant (His & Myc)

LDH,L-lactate dehydrogenase

Plasmodium berghei E. coli
N/A. L-lactate dehydrogenase Protein, Plasmodium berghei, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.4 kDa and the accession number is Q7SI97.
TMPY-04241 LDHA Protein, Rat, Recombinant (His)

lactate dehydrogenase A

Rat E. coli
LDHA Protein, Rat, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 38.7 kDa and the accession number is B5DEN4.
TMPY-00010 LDHA Protein, Mouse, Recombinant (His)

Ldh1,lactate dehydrogenase A,Ldhm,l7R2

Mouse E. coli
LDHA Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P06151.
TMPH-01614 LDHC Protein, Human, Recombinant (His & SUMO)

LDH-X,L-lactate dehydrogenase C chain,Cancer/testis...

Human E. coli
Possible role in sperm motility.
TMPJ-00797 LDHB Protein, Human, Recombinant (His)

LDH-B,Renal Carcinoma Antigen NY-REN-46,LDH-H,LDH Heart Subu...

Human E. coli
L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family that consists of three members, LDH-A, LDH-B and LDH-C; members of this family function as powerful markers for germ cell tumors. LDH-B is an oxidoreductase that catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. It converts pyruvate to lactate when oxygen is absent or in short supply and it performs the reverse reaction during the Cori cycle in the liver....
TMPJ-00724 LDHA Protein, Human, Recombinant (His)

LDH-M,Renal Carcinoma Antigen NY-REN-59,Cell Proliferation-I...

Human E. coli
L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region, a central catalytic site, and at least nine utilized Lys acetylation and two Tyr phosphorylation sites. LDHA belongs to the lactate dehydrogenase family, expressed predominantly in muscle tissue. LDHA mutations have been linked to exertional myoglobinuria.
TMPY-04826 LILRB5/CD85c Protein, Human, Recombinant (His)

leukocyte immunoglobulin like receptor B5,LIR8,LIR-8,CD85C

Human HEK293 Cells
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weig...
TMPH-01696 SLC16A4 Protein, Human, Recombinant (His)

SLC16A4,Monocarboxylate transporter 5,Solute carrier family ...

Human E. coli
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. SLC16A4 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 17.7 kDa and the accession number is O15374.
TMPY-05186 LILRB5/CD85c Protein, Human, Recombinant (His), Biotinylated

LIR-8,LIR8,leukocyte immunoglobulin like receptor B5,CD85C

Human HEK293 Cells
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted ...
TMPY-06273 LILRB5/CD85c Protein, Human, Recombinant (hFc)

LIR-8,LIR8,CD85C,leukocyte immunoglobulin like receptor B5

Human HEK293 Cells
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weig...
TMPH-01202 D2HGDH Protein, Human, Recombinant (His & SUMO)

D2HGD,D2HGDH,D-2-hydroxyglutarate dehydrogenase, mitochondri...

Human E. coli
Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.
TMPY-02288 Glyoxalase II/HAGH Protein, Human, Recombinant (His)

HAGH1,GLO2,GLX2,hydroxyacylglutathione hydrolase,GLXII

Human E. coli
HAGH (Hydroxyacylglutathione Hydrolase) is a Protein Coding gene. 3 alternative splicing and alternative initiation of human isoforms have been reported. The enzyme encoded by this gene is classified as a thioesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. HAGH belongs to the Metallo-beta-lactamase superfamily. HAGH is widely expressed in the kidney, liver, and other tissues. Diseases associated with HAGH include Hydroxyacyl Glutathio...

重组蛋白

PfLDH Protein, P. falciparum, Recombinant (His)
Cat.No: TMPY-04180
Species: P. falciparum
Expression System: E. coli
L-lactate dehydrogenase Protein, E. coli O9:H4, Recombinant (His)
Cat.No: TMPH-00693
Species: E. coli
Expression System: E. coli
L-lactate dehydrogenase Protein, Plasmodium berghei, Recombinant (His & Myc)
Cat.No: TMPH-03136
Species: Plasmodium berghei
Expression System: E. coli
LDHA Protein, Rat, Recombinant (His)
Cat.No: TMPY-04241
Species: Rat
Expression System: E. coli
LDHA Protein, Mouse, Recombinant (His)
Cat.No: TMPY-00010
Species: Mouse
Expression System: E. coli
LDHC Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01614
Species: Human
Expression System: E. coli
LDHB Protein, Human, Recombinant (His)
Cat.No: TMPJ-00797
Species: Human
Expression System: E. coli
LDHA Protein, Human, Recombinant (His)
Cat.No: TMPJ-00724
Species: Human
Expression System: E. coli
LILRB5/CD85c Protein, Human, Recombinant (His)
Cat.No: TMPY-04826
Species: Human
Expression System: HEK293 Cells
SLC16A4 Protein, Human, Recombinant (His)
Cat.No: TMPH-01696
Species: Human
Expression System: E. coli
LILRB5/CD85c Protein, Human, Recombinant (His), Biotinylated
Cat.No: TMPY-05186
Species: Human
Expression System: HEK293 Cells
LILRB5/CD85c Protein, Human, Recombinant (hFc)
Cat.No: TMPY-06273
Species: Human
Expression System: HEK293 Cells
D2HGDH Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01202
Species: Human
Expression System: E. coli
Glyoxalase II/HAGH Protein, Human, Recombinant (His)
Cat.No: TMPY-02288
Species: Human
Expression System: E. coli
Cat. No. Product Name Target Signaling Pathways
T41001 L-Lactic acid-13C3

L-Lactic acid-13C3,(S)-2-hydroxypropanoic-13-C3

L-Lactic acid-13C3 is a stable isotope labeled L-Lactic acid analog. L-Lactic acid-13C3 can be used for lactate metabolism research.
T71305 Clofibric Acid-d4

Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a transactivation assay) and the active metabolite of clofibrate. It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxal...

同位素标记化合物

L-Lactic acid-13C3
Cat.No: T41001
Synonym: L-Lactic acid-13C3,(S)-2-hydroxypropanoic-13-C3
Target:
Clofibric Acid-d4
Cat.No: T71305
Synonym:
Target:
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