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Targets Recommended: Antibacterial Antibiotic

220

抑制剂 & 化合物

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4

化合物库

207

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同位素标记化合物

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Cat. No. Product Name
L9810 抗纤维化化合物库

1180 compounds
1180 种潜在的抗纤维化分子,是研究纤维化的有效工具,可以用于高通量筛选和高内涵筛选;
L4700 免疫/炎症分子化合物库

4720 compounds
4720 种具有抗炎症活性的化合物的特有集合,可用于高通量筛选和高内涵筛选;
L7110 抗高血压化合物库

678 compounds
678 种高血压相关的小分子,用于高通量和高内涵筛选;
L2550 谷氨酰胺代谢化合物库

565 compounds
565 种谷氨酰胺代谢相关的分子,可以用于高通量和高内涵筛选;

化合物库

抗纤维化化合物库
Cat.No: L9810
Compounds: 1180
免疫/炎症分子化合物库
Cat.No: L4700
Compounds: 4720
抗高血压化合物库
Cat.No: L7110
Compounds: 678
谷氨酰胺代谢化合物库
Cat.No: L2550
Compounds: 565
Cat. No. Product Name Target Signaling Pathways
T8134 Cefathiamidine

Antibacterial; Antibiotic Microbiology/Virology
Cefathiamidine 是一种头孢菌素抗菌剂,可研究由易感细菌引起的感染,还可用于呼吸道、肝脏、五官感觉、尿路感染以及心内膜炎和败血症的研究。
T27246 EG1

Others Others
EG1 是特异性 Pax2<.b> 抑制剂,能够直接结合 Pax2 的配对结构域 (Kd:1.35-1.5 μM) ,可阻碍 Pax2-DNA 相互作用。它能够抑制胚胎肾脏发育,此过程直接依赖于 Pax2活性。
T37596 Terevalefim

c-Met/HGFR Tyrosine Kinase/Adaptors
Terevalefim 是干细胞生长因子的一种类似物,对c-Met 受体有选择性激活作用。
TP1187 C-Type Natriuretic Peptide (CNP) (1-22), human

CNP (1-22), human

RAAS Endocrinology/Hormones
C-Type Natriuretic Peptide (CNP) (1-22), human 是一种利钠肽受体 B (NPR-B) 激动剂,是一种 CNP 的 1-22 片段。它对生理激动剂组胺和 5-HT 刺激或直接由 Forskolin 刺激的 cAMP 合成具有抑制作用。其中CNP 是一种有效的、内皮衍生的松弛剂和生长抑制因子。
T22428 Sodium Glucoheptonate

Sodium glucoheptonate,葡萄醣庚酸钠

Others Others
Sodium Glucoheptonate 可用作 Tc-99m 放射性标记的试剂盒,也可用于清洗金属、丝光、脱漆和铝蚀刻。其中Tc-99m glucoheptonate 是一种肾脏和脑部成像剂,可用于检测脑肿瘤。
T9615 CK7

CDK Cell Cycle/Checkpoint
CK7是有效的Cdk2/9抑制剂。CK7可用于合成 Nek1 抑制剂 BSc5231 和BSc5367。
T7802 M1001

HIF/HIF Prolyl-Hydroxylase; HIF Angiogenesis; Chromatin/Epigenetic; Metabolism
M1001 是较弱的HIF-2α激动剂,直接与 HIF-2α PAS-B 结构域结合,Kd=667 nM,能够提高 HIF-2α-ARNT 复合体之间的稳定性。
T23133 Pentamidine

Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal Metabolism; Microbiology/Virology
Pentamidine 是抗微生物剂,会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病,抗锑利什曼病和卡氏肺孢子虫肺炎的研究,有抗肿瘤活性,抗菌活性。
T16724 Razuprotafib

AKB-9778

Phosphatase; Others Metabolism; Others
Razuprotafib (AKB-9778) 是一种 VE-PTP (HPTPß)催化活性的有效选择性抑制剂,抑制结构相关磷酸酶 PTP1B。除 HPTPη 和 HPTPγ 外,它对 VE-PTP 具有良好的选择性。它能够促进 TIE2 活化,增强 ANG1 诱导的 TIE2 活化,并刺激 TIE2 通路中信号分子的磷酸化。
T9022 AZD9977

AZD 9977

Glucocorticoid Receptor Endocrinology/Hormones
AZD9977 是一种选择性的,有效的,具有口服活性的盐皮质激素受体 (MR) 调节剂,可用于研究心力衰竭和慢性肾病。
T8528 AC1903

TRP/TRPV Channel Membrane transporter/Ion channel
AC1903是一种选择性的TRPC5抑制剂,具有足细胞保护特性,对 TRPC4 或 TRPC6没有影响,并且在激酶谱分析中没有显示出脱靶效应。在局灶节段性肾小球硬化大鼠模型中,AC1903抑制严重蛋白尿,并且防止足细胞丢失。
T28410 PHPS1

PHPS-1,PHPS 1

Phosphatase Metabolism
PHPS1 是 Shp2的选择性抑制剂,对 Shp2,Shp2-R362K,Shp1,PTP1B 和 PTP1B-Q 的 Ki 分别为 0.73,5.8,10.7,5.8 和 0.47 μM。
T11394 GFB-8438

TRP/TRPV Channel Membrane transporter/Ion channel
GFB-8438 是有效的TRPC5选择性抑制剂,对 hTRPC5 和 hTRPC4 的IC50分别为 0.18 和 0.29 μM。它对 TRPC6、其他 TRP 家族成员、NaV1.5 具有良好的选择性,对 hERG 通道的活性也有限。它对小鼠足细胞的保护作用。
T6848 GSK1016790A

GSK101

Calcium Channel; TRP/TRPV Channel Membrane transporter/Ion channel; Metabolism
GSK1016790A (GSK101) 是选择性瞬时受体电位香草酸 4 通道激活剂,可引起 HEK 细胞中 Ca2+流入并升高细胞内 Ca2+。
T1874 PPQ-102

PPQ102,CFTR Inhibitor,PPQ 102

CFTR; Autophagy Autophagy; Membrane transporter/Ion channel
PPQ-102 (CFTR Inhibitor) 是一种CFTR 抑制剂,可以完全抑制CFTR 氯化物电流,IC50为90 nM。
T8930 CID44216842

KUC103479N-02

CDK; Ras Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
CID44216842 (KUC103479N-02) 是Cdc42选择性抑制剂。在 GDP 结合测定中,它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 0.3 和 0.5 μM。在 GTP 结合测定中,它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 1.0 和 1.2 μM。它可用作分子探针。
T12883 Fezagepras

PBI-4050,3-戊基苯乙酸,Setogepram

GPR Endocrinology/Hormones; GPCR/G Protein
Fezagepras (Setogepram) 是一种可口服的 GPR40激动剂和GPR84拮抗剂或反向激动剂。它减轻肾、肝和胰腺纤维化,具有抗纤维化、抗炎和抗增殖作用。
T1654 Pentamidine isethionate

Pentamidine isethionate salt,Pentamidine diisethionate,喷他脒羟乙磺酸盐

Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal Metabolism; Microbiology/Virology
Pentamidine isethionate (Pentamidine diisethionate) 是抗微生物剂,会干扰 DNA 的生物合成。它抑制寄生虫Leishmania infantum,IC50为 2.5 μM。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它有抗肿瘤和抗菌活性。
T10353 APX-115 free base

Ewha-18278 free base

NADPH-oxidase; NADPH Immunology/Inflammation; Metabolism
APX-115 free base (Ewha-18278 free base) 是口服具有活性的、非选择性的 Nox 抑制剂,对 Nox1,Nox2和 Nox4的 Ki 分别为 1.08 μM,0.57 μM 和 0.63 μM。它能够有效预防糖尿病小鼠的肾损伤。
T4583 PFI-2 hydrochloride

(R)-PFI-2 hydrochloride,PFI-2 HCl

Histone Methyltransferase Chromatin/Epigenetic
PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) 是一种有效的、高度选择性的、具有细胞活性的 SETD7 甲基转移酶抑制剂,IC50值为2nM,活性是 (S)-PFI-2 的 500 倍。
T1615 Irbesartan

厄贝沙坦,SR-47436,BMS-186295

Apoptosis; RAAS Apoptosis; Endocrinology/Hormones
Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂,IC50为1.3 nM。
T23132 Pentamidine dihydrochloride

喷他脒二盐酸盐,MP-601205 dihydrochloride

Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal Metabolism; Microbiology/Virology
Pentamidine dihydrochloride (MP-601205 dihydrochloride) 是一种抗微生物剂,会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病,抗锑利什曼病和卡氏肺孢子虫肺炎的研究,有抗肿瘤活性,抗菌活性。
T2131 Articaine hydrochloride

Ultracaine,盐酸阿替卡因,阿替卡因,Articaine HCl,Hoe-045

Sodium Channel Membrane transporter/Ion channel
Articaine hydrochloride (Hoe-045) 一种牙科局部麻醉剂。
T4651 Vadadustat

N-(5-(3-氯苯基)-3-羟基吡啶-2-羰基)甘氨酸,PG-1016548,AKB-6548

HIF/HIF Prolyl-Hydroxylase; HIF Angiogenesis; Chromatin/Epigenetic; Metabolism
Vadadustat 是一种可滴定口服的缺氧诱导因子脯氨酰羟化酶 (HIF-PH) 抑制剂,是一种促红细胞生成剂,在动物慢性肾脏疾病模型中,有用于贫血的研究潜力。
T21395 Finerenone

BAY948862,BAY-948862,BAY94-8862,非奈利酮,BAY 94-8862,BAY-94-8862,BAY 948862

Glucocorticoid Receptor Endocrinology/Hormones
Finerenone (BAY-948862) 是一种选择性、具有口服活性的、非甾体类盐皮质激素受体拮抗剂 (IC50=18 nM)。与糖皮质激素受体、雄激素受体和孕酮受体相比,它表现出良好的选择性 (>500-fold)。它在心肾疾病研究中具有潜在的应用前景,如 2 型糖尿病和慢性肾脏疾病。
T6666 Sevelamer Carbonate

Others Others
Sevelamer carbonate 是一种口服具有活力的非钙基磷酸盐结合剂,能有效降低体内血清磷水平,但对体内血清钙、氯水平影响极小,可用于研究慢性肾脏病的高磷血症。它被认为是七氟乙烯的一种改进的缓冲形式。
T1987 PFI-2

PFI2,PFI 2,(R)-PFI-2

Histone Methyltransferase Chromatin/Epigenetic
PFI-2 是一种有效、特异性和细胞活性的赖氨酸甲基转移酶 SETD7 抑制剂,Ki 和 IC50值分别为 0.33 和 2 nM。
T35300 Zeniplatin

Zeniplatinum

Others Others
Zeniplatin (Zeniplatinum) 是一种新顺铂复合物,具有抗癌活性,可用于治疗转移性黑色素瘤和肾癌。
T40108 Inaxaplin

VX-147

Others Others
Inaxaplin 是一种载脂蛋白L1(APOL1)功能抑制剂。Inaxaplin 可用于肾脏疾病的研究。
T10591L (R)-BPO-27

CFTR; Autophagy Autophagy; Membrane transporter/Ion channel
(R)-BPO-27 是一种具有口服活性和高效性的 ATP 竞争性 CFTR 抑制剂(IC50:4 nM),可用于研究腹泻和多囊肾。
T33856 6-Acryloyloxyhexyl phosphate

PA21

Others Others
6-Acryloyloxyhexyl phosphate (PA21) 是一种新型磷酸盐结合剂,属于铁基试剂,可用于治疗慢性肾脏病中的高磷血症。
T67916 CYP4A11/CYP4F2-IN-2

P450 Metabolism
CYP4A11/CYP4F2-IN-2 是一种有效的和具有口服活性的细胞色素 P450 (CYP) 4A11 和 CYP4F2 的双重抑制剂,IC50 值分别为 140 nM 和 40 nM。CYP4A11/CYP4F2-IN-2可从肝脏和肾脏中提取, 具有治疗肾脏疾病的潜力。
T19654 Guanoclor

胍氯酚,VATENSOL

Others Others
Guanoclor (VATENSOL) 也称为guanochlor,是一种交感神经药物。已知它与猪肾膜中的非肾上腺素能位点结合。
T23867 Cdc7-IN-7c

Cdc7 inhibitor-7c,Cdc7 inhibitor 7c,Cdc7 IN 7c

CDK Cell Cycle/Checkpoint
Cdc7-IN-7c (Cdc7 inhibitor-7c) 具有抗肿瘤活性,对肝癌,肺癌,肾癌,脑癌,宫颈癌有抑制作用。
T13591 Calcium polystyrene sulfonate

Poly(styrenesulfonic acid) calcium salt,聚苯乙烯磺酸钙

Others Others
Calcium polystyrene sulfonate (Poly(styrenesulfonic acid) calcium salt) 是一种离子交换树脂。 Calcium polystyrene sulfonate 可降低血钾水平,可用于治疗慢性肾病患者高钾血症的研究。
T67941 PDE5-IN-9

Others Others
PDE5-IN-9对Phosphodiesterase PDE1c 具有抑制作用,可用来治疗高血压、心力衰竭、心肌梗塞、肾衰竭、哮喘、支气管炎和痴呆。
T0080 Trapidil

唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008

PDGFR; PDE Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
Trapidil (Avantrin) 是一种抗血小板药物,是一种血管扩张剂,有特异性血小板衍生生长因子。
T77006 Felzartamab

TJ-202,MOR-03087,MOR-202

CD38 Immunology/Inflammation
Felzartamab(MOR-202) 是一种人源靶向 CD38 的单克隆抗体,可用于研究多发性骨髓瘤和晚期抗体介导的同种异体肾移植排斥反应。
T6397 Atracurium besylate

Tracrium,51W89,BW-33A,苯磺酸阿曲库铵

AChR Neuroscience
Atracurium besylate (51W89) 是一种神经肌肉阻断剂,ED95为0.2 mg/kg。
T77364 Sibeprenlimab

VIS649,VIS-649

Others Others
Sibeprenlimab (VIS649) 是一种抑制 APRIL 的人源化IgG 2单克隆抗体。Sibeprenlimab 对 APRIL 有抑制作用,可用于研究预防和治疗 肾病(IgAN)。
T73698 Basiliximab

CHI 621

Interleukin Immunology/Inflammation
Basiliximab (CHI 621) 是一种嵌合鼠/人 IgG1 单克隆抗白细胞介素 2 受体 (interleukin-2 receptor) 重组抗体。Basiliximab 具有良好的免疫抑制活性,可用于研究肾移植。
T77362 Vorsetuzumab

SGN-70

Immunology/Inflammation related Immunology/Inflammation
Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) 是靶向 CD70 抗体的单克隆抗体。Vorsetuzumab 具有抗癌活性,能够加强肾癌细胞巨噬相关吞噬作用,抑制 Burkitt 淋巴瘤。
T5850 Benzamil

Benzamil (hydrochloride)

Na+/Ca2+ Exchanger; Sodium Channel Membrane transporter/Ion channel
Benzamil 是 Amiloride 类似物,是 Na+/Ca2+交换体抑制剂,抑制 TRPP3 介导的 Ca2+激活电流,IC50为 1.1 μM。它也是一种非选择性上皮钠通道 (ENaC) 阻滞剂,能增强肌源性血管收缩。
T72501 CYP4A11/CYP4F2-IN-1

P450 Metabolism
CYP4A11/CYP4F2-IN-1 是一种高效的小分子细胞色素 P450 (CYP) 4A11 和 CYP4F2 抑制剂,对P450 (CYP) 4A11 的 IC50 值为 19 nM,对 CYP4F2 的 IC50 值为 17 nM。CYP4A11/CYP4F2-IN-1 可用于研究肾脏疾病和心脑血管疾病。
T50000 2-Iodohippuric Acid

Others Others
2-Iodohippuric Acid 可以用来测量肾脏的清除率用于肾功能研究,也用于某些疾病的诊断,如肝病和肾病。此外,它还用于某些药物的合成。
T37825 CAY10434

P450 Metabolism
CAY10434是一种有作用的 CYP4A 羟化酶 (CYP4A hydroxylase) 抑制剂,在人肾微粒体测试中的 IC50值为8.8 nM。CAY 10434 在改善血管紧张素 II 的收缩过程中 Emax 为 6764 mg。
T60170 BLU2864

Others Others
BLU2864 是一种具有口服活性的、高选择性的、ATP 竞争性的 PRKACA 抑制剂 ,IC50值为0.3 nM。BLU2864 具有抗肿瘤活性,具有用于癌症和多囊肾的研究潜力。
T0374L Sunitinib

苏尼替尼,舒尼替尼,SU 11248

Apoptosis; Mitophagy; VEGFR; FLT; IRE1; PDGFR; c-Kit; Autophagy Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
Sunitinib (SU 11248) 是一种多靶点受体酪氨酸激酶 (RTK) 抑制剂,可以抑制 VEGFR2 和 PDGFRβ (IC50=80/2 nM)。Sunitinib 具有抗肿瘤活性,可以用于治疗肾癌和胃肠道肿瘤。
T7587 Tenapanor

RDX-5791,RDX 5791,AZD 1722,Tenapanor free base,RDX5791,AZD-1722,AZD1722

Sodium Channel Membrane transporter/Ion channel
Tenapanor (RDX 5791) 是钠氢离子交换NHE3的有效抑制剂, 对人和大鼠NHE3的IC50分别是5和10 nM。
T40109 APOL1-IN-1

APOL1-IN-1

Others Others
APOL1-IN-1是一种有效的载脂蛋白 L1(APOL1) 的抑制剂,可用于研究局灶节段性肾小球硬化 (FSGS) 和非糖尿病肾病 (NDKD) 的发病原理,促进对此类疾病的研究。

化合物

Cefathiamidine
Cat.No: T8134
Synonym:
Target: Antibacterial, Antibiotic
EG1
Cat.No: T27246
Synonym:
Target: Others
Terevalefim
Cat.No: T37596
Synonym:
Target: c-Met/HGFR
C-Type Natriuretic Peptide (CNP) (1-22), human
Cat.No: TP1187
Synonym: CNP (1-22), human
Target: RAAS
Sodium Glucoheptonate
Cat.No: T22428
Synonym: Sodium glucoheptonate,葡萄醣庚酸钠
Target: Others
CK7
Cat.No: T9615
Synonym:
Target: CDK
M1001
Cat.No: T7802
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
Pentamidine
Cat.No: T23133
Synonym:
Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal
Razuprotafib
Cat.No: T16724
Synonym: AKB-9778
Target: Phosphatase, Others
AZD9977
Cat.No: T9022
Synonym: AZD 9977
Target: Glucocorticoid Receptor
AC1903
Cat.No: T8528
Synonym:
Target: TRP/TRPV Channel
PHPS1
Cat.No: T28410
Synonym: PHPS-1,PHPS 1
Target: Phosphatase
GFB-8438
Cat.No: T11394
Synonym:
Target: TRP/TRPV Channel
GSK1016790A
Cat.No: T6848
Synonym: GSK101
Target: Calcium Channel, TRP/TRPV Channel
PPQ-102
Cat.No: T1874
Synonym: PPQ102,CFTR Inhibitor,PPQ 102
Target: CFTR, Autophagy
CID44216842
Cat.No: T8930
Synonym: KUC103479N-02
Target: CDK, Ras
Fezagepras
Cat.No: T12883
Synonym: PBI-4050,3-戊基苯乙酸,Setogepram
Target: GPR
Pentamidine isethionate
Cat.No: T1654
Synonym: Pentamidine isethionate salt,Pentamidine diisethionate,喷他脒羟乙磺酸盐
Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal
APX-115 free base
Cat.No: T10353
Synonym: Ewha-18278 free base
Target: NADPH-oxidase, NADPH
PFI-2 hydrochloride
Cat.No: T4583
Synonym: (R)-PFI-2 hydrochloride,PFI-2 HCl
Target: Histone Methyltransferase
Irbesartan
Cat.No: T1615
Synonym: 厄贝沙坦,SR-47436,BMS-186295
Target: Apoptosis, RAAS
Pentamidine dihydrochloride
Cat.No: T23132
Synonym: 喷他脒二盐酸盐,MP-601205 dihydrochloride
Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal
Articaine hydrochloride
Cat.No: T2131
Synonym: Ultracaine,盐酸阿替卡因,阿替卡因,Articaine HCl,Hoe-045
Target: Sodium Channel
Vadadustat
Cat.No: T4651
Synonym: N-(5-(3-氯苯基)-3-羟基吡啶-2-羰基)甘氨酸,PG-1016548,AKB-6548
Target: HIF/HIF Prolyl-Hydroxylase, HIF
Finerenone
Cat.No: T21395
Synonym: BAY948862,BAY-948862,BAY94-8862,非奈利酮,BAY 94-8862,BAY-94-8862,BAY 948862
Target: Glucocorticoid Receptor
Sevelamer Carbonate
Cat.No: T6666
Synonym:
Target: Others
PFI-2
Cat.No: T1987
Synonym: PFI2,PFI 2,(R)-PFI-2
Target: Histone Methyltransferase
Zeniplatin
Cat.No: T35300
Synonym: Zeniplatinum
Target: Others
Inaxaplin
Cat.No: T40108
Synonym: VX-147
Target: Others
(R)-BPO-27
Cat.No: T10591L
Synonym:
Target: CFTR, Autophagy
6-Acryloyloxyhexyl phosphate
Cat.No: T33856
Synonym: PA21
Target: Others
CYP4A11/CYP4F2-IN-2
Cat.No: T67916
Synonym:
Target: P450
Guanoclor
Cat.No: T19654
Synonym: 胍氯酚,VATENSOL
Target: Others
Cdc7-IN-7c
Cat.No: T23867
Synonym: Cdc7 inhibitor-7c,Cdc7 inhibitor 7c,Cdc7 IN 7c
Target: CDK
Calcium polystyrene sulfonate
Cat.No: T13591
Synonym: Poly(styrenesulfonic acid) calcium salt,聚苯乙烯磺酸钙
Target: Others
PDE5-IN-9
Cat.No: T67941
Synonym:
Target: Others
Trapidil
Cat.No: T0080
Synonym: 唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008
Target: PDGFR, PDE
Felzartamab
Cat.No: T77006
Synonym: TJ-202,MOR-03087,MOR-202
Target: CD38
Atracurium besylate
Cat.No: T6397
Synonym: Tracrium,51W89,BW-33A,苯磺酸阿曲库铵
Target: AChR
Sibeprenlimab
Cat.No: T77364
Synonym: VIS649,VIS-649
Target: Others
Basiliximab
Cat.No: T73698
Synonym: CHI 621
Target: Interleukin
Vorsetuzumab
Cat.No: T77362
Synonym: SGN-70
Target: Immunology/Inflammation related
Benzamil
Cat.No: T5850
Synonym: Benzamil (hydrochloride)
Target: Na+/Ca2+ Exchanger, Sodium Channel
CYP4A11/CYP4F2-IN-1
Cat.No: T72501
Synonym:
Target: P450
2-Iodohippuric Acid
Cat.No: T50000
Synonym:
Target: Others
CAY10434
Cat.No: T37825
Synonym:
Target: P450
BLU2864
Cat.No: T60170
Synonym:
Target: Others
Sunitinib
Cat.No: T0374L
Synonym: 苏尼替尼,舒尼替尼,SU 11248
Target: Apoptosis, Mitophagy, VEGFR, FLT, IRE1, PDGFR, c-Kit, Autophagy
Tenapanor
Cat.No: T7587
Synonym: RDX-5791,RDX 5791,AZD 1722,Tenapanor free base,RDX5791,AZD-1722,AZD1722
Target: Sodium Channel
APOL1-IN-1
Cat.No: T40109
Synonym: APOL1-IN-1
Target: Others
Cat. No. Product Name Target Signaling Pathways
T2S1837 Steviol

甜菊醇,NSC 226902,Hydroxydehydrostevic acid

Others Others
Steviol (NSC-226902) 是一种甜菊糖甙的主要代谢物。它能降低 AQP2 的表达,并促进 AQP2 的降解,从而减缓肾囊肿的生长。
T14002 12-Ketodeoxycholic acid

Endogenous Metabolite Metabolism
12-Ketodeoxycholic acid 是一种胆汁酸,由肾脏代谢产生。它是肾脏损伤的标志物。
T1313 Nitrofurantoin

Furadantine,呋喃妥因,Macrodantin,Furadonine

Antibacterial; Antibiotic Microbiology/Virology
Nitrofurantoin (Furadantine) 是一种具有口服活性的广谱内酰胺酶抗菌剂。它是一种抗生素,可研究尿路感染。
T2870 Matrine

Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine

Mitophagy; Ferroptosis; Opioid Receptor; Autophagy Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience
Matrine (Vegard) 是一种从槐属植物中分离出来的生物碱,可作为一种κ阿片受体激动剂,有抗肿瘤活性。
T0496 Creatinine

肌酸酐,NSC13123

Endogenous Metabolite Metabolism
Creatinine (NSC-13123) 由肌肉中磷酸肌酸分解产生。
T33817 Orellanine

2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one

Others Others
Orellanine 是一种从蘑菇 Cortinarius orellanus 中提取的肾毒性化合物。 Orellanine 强烈抑制 Madin-Darby 犬肾细胞和大鼠肝线粒体中大分子(蛋白质、RNA 和 DNA)的合成。
T0281 Meclocycline sulfosalicylate salt

磺基水杨酸甲氯环素,Meclutin,Mecloderm,甲环素磺基水杨酸盐,Meclan Cream

Antibacterial; Antibiotic Microbiology/Virology
Meclocycline sulfosalicylate salt (Mecloderm) 是一种具有广谱抗菌活性的四环素抗生素,可预防皮肤细菌感染。
T3670 Forsythiaside A

Forsythiaside,Forsythoside A,连翘脂苷A,连翘酯苷A

Others Others
Forsythiaside A (Forsythiaside) 是一种苯乙醇苷产品,从连翘的风干果实中分离获得,具有抗炎和抗氧化活性。
T21977 p-Cresyl sulfate

Others Others
p-Cresyl Sulfate 是主要的尿毒症毒素,存在于慢性肾病患者的血液,来源于肝脏中酪氨酸和苯丙氨酸的代谢物。
T13818 Phytohemagglutinin

PHA-M,植物血球凝集素,PHA,植物血凝素

Apoptosis Apoptosis
Phytohemagglutinin (PHA-M) 是一种普通豆菜豆的主要种子凝集素,聚集在子叶的薄壁细胞中。它是一种 T 细胞激活剂,能够刺激人单核白细胞,可诱导 ChAT mRNA 表达,增强 ACh 合成。
T21418 Lisinopril

Linopril,赖诺普利,Zestril,Prinivil,Lisipril

RAAS Endocrinology/Hormones
Lisinopril (Prinivil) 是一种血管紧张素转化酶抑制剂,能够作用于高血压,充血性心力衰竭和心脏病等。
T3887 Rosarin

Others Others
Rosarin 是从玫瑰红景天中分离出来的肉桂醇糖苷。它抑制小鼠肾脏和大脑前额皮层中促炎因子 iNOS,IL-1β 和 TNF-α 的表达。它具有抗炎和神经保护作用。
T22311 Djenkolic Acid

jengkolic acid,Djenkolate,3,3'-(亞甲二硫)雙丙胺酸,S,S'-Methylenebiscysteine

Others Others
Djenkolic Acid (S,S'-Methylenebiscysteine) 是天然存在于东南亚植物 Archidendron jiringa 的 Djenkol 豆中的含硫非蛋白质氨基酸。它是人类急性肾损伤的一个不常见但重要的原因。
T4238 Glycocyamine

乙酸胍,2-Guanidinoacetic acid,Guanidoacetic acid

Others; Endogenous Metabolite Metabolism; Others
Glycocyamine (2-Guanidinoacetic acid) 是一种肌酸的前体,能够为鸟类的体内平衡提供能量,也能够成为食用精氨酸的替代物。
T6805 Choline bitartrate

2,3,4-trihydroxy-4-oxobutanoate,2-hydroxyethyl(trimethyl)azanium,酒石酸氢胆碱

Others; AChR Neuroscience; Others
Choline bitartrate (2-hydroxyethyl(trimethyl)azanium) 是一种存在于食物中的营养胆碱,可影响肝脏疾病、动脉粥样硬化和神经系统疾病等疾病。它是神经递质乙酰胆碱的前体,作为甲基供体参与各种代谢过程和脂质代谢。
T5S0167 Atractylenolide I

白术内酯 I,白术内酯I;苍术内酯I

IL Receptor; TNF; TLR; JAK; STAT Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells
Atractylenolide I 是从白术根中得到的一种倍半萜烯,具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂,在 A375 细胞中,能够降低JAK2和STAT3的磷酸化水平。
T4010 Juglone

5-羟基对萘醌,5-Hydroxy-1,4-naphthoquinone,胡桃酮,Regianin

DNA/RNA Synthesis; Antibacterial Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
Juglone (Regianin) 是一种从黑胡桃Juglans regia 中发现的黄色染料,有抗菌作用。
T5623 Bisphenol A

Others; Endogenous Metabolite Metabolism; Others
Bisphenol A 是酚类内源性代谢合成物,广泛用于环氧树脂和聚碳酸酯塑料的生产。它是生殖、发育和全身毒性物质,常被归类为内分泌干扰物。它与许多疾病有关,包括呼吸系统疾病、心血管疾病、糖尿病、肾脏疾病、肥胖和生殖障碍。
T7031 Aristolochic acid B

马兜铃酸B,Aristolochic Acid II,马兜铃酸 B

DNA DNA Damage/DNA Repair
Aristolochic acid B (Aristolochic Acid II) 是一种来自马兜铃科分类群的天然产物,是马兜铃酸的主要成分之一。 已知马兜铃酸是诱变剂和致癌物质。它在体内表现出比 Aristolochic acid I 更大的致癌风险。
T0414 D-Mannitol

Mannite,Mannitol,D-甘露糖醇,Osmitrol

Apoptosis; Dehydrogenase; Endogenous Metabolite Apoptosis; Metabolism
D-Mannitol (Mannitol) 是与山梨醇相关的利尿剂和肾脏诊断辅助剂,具有较弱的肾脏血管扩张活性。
TJS0387 Desoxyrhaponticin

去氧土大黄苷,Deoxyrhapontin,脱氧土大黄苷,Deoxyrhaponticin

Apoptosis; Fatty Acid Synthase Apoptosis; Metabolism
Desoxyrhaponticin (Deoxyrhaponticin) 是来自西藏营养食品唐古特大黄中的一种二苯乙烯苷。它是脂肪酸合成酶抑制剂,抑制细胞内 FAS 活性,下调人乳腺癌 MCF-7细胞中 FAS 的表达。它是控制糖尿病餐后高血糖的潜在药物。
T3746 Dimethyl phthalate

邻苯二甲酸二甲酯,Solvanom,Avolin,Fermine,避蚊酯

Others Others
Dimethyl phthalate (Fermine) 是一种邻苯二甲酸酯 (PAEs),是一种已知的内分泌干扰物,也是一种普遍存在的污染物。它常作为增塑剂,赋予硬质聚氯乙烯 (PVC) 树脂以柔韧性。
T5306 H-Abu-OH

L-2-氨基丁酸,L-Aminobutyric Acid,L-α-amino-n-Butyric acid,L(+)-2-Aminobutyric acid

Others; Endogenous Metabolite Metabolism; Others
H-Abu-OH (L-α-amino-n-Butyric acid) 是氨基丁酸的三个同分异构体之一,它在患有雷氏综合征,同型血尿症,酪氨酸血症,非酮糖症以及鸟氨酸转氨酶症等代谢病儿童的血浆中的含量会明显升高。
T8274 3-Methyl-L-histidine

Endogenous Metabolite Metabolism
3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
T4938 Potassium 1H-indol-3-yl sulfate

硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate

AhR; Endogenous Metabolite Immunology/Inflammation; Metabolism
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂,Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚,吲哚被吸收到血液中,然后在肝脏中进一步代谢为硫酸吲哚,通常通过尿液排出体外。在肾功能受损的慢性肾病患者中,Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累,诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化,促进大鼠近端小管细胞TGF-β1和Smad3的表达,与促纤维化活性相关。
T4776 Glycerol

Glycerin,甘油

Endogenous Metabolite Metabolism
Glycerol 是甘油三酯(即脂肪和油)和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
T21261 Phaseolin

Phaseolin, a protein from red kidney bean (Phaseolus vulgaris L.), plays a pivotal role in hypersensitivity induction.
T27380 FR-198248

Others Others
FR-198248, a new anti-influenza agent, shows antiinfluenza virus activity in Madin-Darby canine kidney (MDCK) cells in vitro.
TN7367 trans-Psoralenoside

Others Others
Trans-Psoralenoside exhibits hepatoprotective (liver-protective), nephroprotective (kidney-protective), antiulcer, and anticoagulant properties.
T39168 Epsilon-(gamma-glutamyl)-lysine

Epsilon-(gamma-glutamyl)-lysine,γ-Glu-ε-Lys,H-Glu(H-Lys-OH)-OH

Others Others
Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative that forms bonds between extracellular matrix (ECM) components with the assistance of the enzyme tissue transglutaminase (tTg). These bonds are implicated in the pathogenesis of certain diseases like non-diabetic kidney and glaucoma filtration.
T82273 Gochnatiolide A

Gochnatiolide A是从Ainsliaea henryi中提取的一种二聚倍半萜烯,对肾脏、黑色素瘤、卵巢抵抗和神经胶质瘤细胞系显示出抗增殖活性。
T36791 Lysophosphatidylcholine 18:2

Others Others
1-Linoleoyl-2-hydroxy-sn-glycero-3-PC (LGPC) is a lysophospholipid containing linoleic acid at thesn-1 position that has been found in mouse heart, lung, liver, spleen, kidney, plasma, and serum.1Serum levels of LGPC decrease with increasing insulin resistance and dysglycemia in humans.2 1.Okudaira, M., Inoue, A., Shuto, A., et al.Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MSJ. Lipid Res.55(10)2178-2192(2014) 2.Gall, ...
TN7284 Lentztrehalose B

Others Others
Lentztrehalose B, a microbial disaccharide metabolite isolated from Lentzea, exhibits a range of biological activities. At a concentration of 100 µM, it demonstrates antioxidant properties in an oxygen radical absorbance capacity (ORAC) assay. Furthermore, Lentztrehalose B at 10 mM inhibits porcine kidney trehalase, an enzyme involved in trehalose metabolism. Additionally, it induces autophagy in MeWo melanoma and OVK18 ovarian cancer cells when applied at 100 mM.
T77988 Phenyl sulfate

Phenyl hydrogen sulfate

Endogenous Metabolite Metabolism
Phenyl sulfate为肠道微生物衍生的口服活性代谢物,能在糖尿病实验模型中诱发蛋白尿及足细胞损伤,其可能成为糖尿病肾病的疾病标志物和未来治疗靶点。
T35532 Galegine hydrochloride

Others Others
Galegine hydrochloride, a guanidine derivative derived from G. officinalis, plays a role in inducing weight loss in mice and has contributed to the development of biguanides, including metformin and phenformin. This compound stimulates AMPK activation in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma, and HEK293 human kidney cell lines. Additionally, galegine hydrochloride exhibits antibacterial properties, particularly demonstrating a minimum inhibitory concentration of 4 mg/L against Staph...
T37291 Lyso-Globotriaosylceramide (d18:1)

Lyso-Globotriaosylceramide (d18:1)

Others Others
Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas...
TMA1743 Ergosterol peroxide

ERK; VEGFR; p38 MAPK; Wnt/beta-catenin; Akt; JAK; CDK; JNK; STAT; Antifection Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to
T75461 Harzianum A

Others Others
Harzianum A 是一种单端孢霉烯化合物,可从 Trichoderma harzianum 中分离得到。Harzianum A 对小仓鼠肾细胞没有细胞毒性,对革兰氏阴性和革兰氏阳性细菌没有活性,但在 100 μg/mL 时具有适度的抗真菌活性。
TN7283 Lentztrehalose A

(+)-Lentztrehalose A

Others Others
Lentztrehalose A, a disaccharide microbial metabolite identified in Lentzea, exhibits a range of biological activities. This compound specifically inhibits M. smegmatis trehalase—an enzyme involved in trehalose metabolism—more effectively than trehalase from porcine kidney, with IC50 values of 0.67 mM and >20 mM, respectively. Additionally, Lentztrehalose A at a concentration of 100 mM promotes autophagy in MeWo melanoma and OVK18 ovarian cancer cells. When administered at 50 mg/kg daily, it enh...
T81630 OAT1/3-IN-1

OAT1/3-IN-1(化合物7)是针对OAT1和OAT3的双重抑制剂。该化合物能逆转Cys-Hg(10 μM)对HEK-OAT1细胞引起的毒害,表明其对肾脏有潜在的保护效应。OAT1/3-IN-1适合用于探究汞引起的肾脏损伤机制研究。
TN2977 3-O-trans-p-Coumaroyltormentic acid

Caspase; Antifection Apoptosis; Microbiology/Virology; Proteases/Proteasome
3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, an...

天然产物

Steviol
Cat.No: T2S1837
Synonym: 甜菊醇,NSC 226902,Hydroxydehydrostevic acid
Target: Others
12-Ketodeoxycholic acid
Cat.No: T14002
Synonym:
Target: Endogenous Metabolite
Nitrofurantoin
Cat.No: T1313
Synonym: Furadantine,呋喃妥因,Macrodantin,Furadonine
Target: Antibacterial, Antibiotic
Matrine
Cat.No: T2870
Synonym: Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine
Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy
Creatinine
Cat.No: T0496
Synonym: 肌酸酐,NSC13123
Target: Endogenous Metabolite
Orellanine
Cat.No: T33817
Synonym: 2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one
Target: Others
Meclocycline sulfosalicylate salt
Cat.No: T0281
Synonym: 磺基水杨酸甲氯环素,Meclutin,Mecloderm,甲环素磺基水杨酸盐,Meclan Cream
Target: Antibacterial, Antibiotic
Forsythiaside A
Cat.No: T3670
Synonym: Forsythiaside,Forsythoside A,连翘脂苷A,连翘酯苷A
Target: Others
p-Cresyl sulfate
Cat.No: T21977
Synonym:
Target: Others
Phytohemagglutinin
Cat.No: T13818
Synonym: PHA-M,植物血球凝集素,PHA,植物血凝素
Target: Apoptosis
Lisinopril
Cat.No: T21418
Synonym: Linopril,赖诺普利,Zestril,Prinivil,Lisipril
Target: RAAS
Rosarin
Cat.No: T3887
Synonym:
Target: Others
Djenkolic Acid
Cat.No: T22311
Synonym: jengkolic acid,Djenkolate,3,3'-(亞甲二硫)雙丙胺酸,S,S'-Methylenebiscysteine
Target: Others
Glycocyamine
Cat.No: T4238
Synonym: 乙酸胍,2-Guanidinoacetic acid,Guanidoacetic acid
Target: Others, Endogenous Metabolite
Choline bitartrate
Cat.No: T6805
Synonym: 2,3,4-trihydroxy-4-oxobutanoate,2-hydroxyethyl(trimethyl)azanium,酒石酸氢胆碱
Target: Others, AChR
Atractylenolide I
Cat.No: T5S0167
Synonym: 白术内酯 I,白术内酯I;苍术内酯I
Target: IL Receptor, TNF, TLR, JAK, STAT
Juglone
Cat.No: T4010
Synonym: 5-羟基对萘醌,5-Hydroxy-1,4-naphthoquinone,胡桃酮,Regianin
Target: DNA/RNA Synthesis, Antibacterial
Bisphenol A
Cat.No: T5623
Synonym:
Target: Others, Endogenous Metabolite
Aristolochic acid B
Cat.No: T7031
Synonym: 马兜铃酸B,Aristolochic Acid II,马兜铃酸 B
Target: DNA
D-Mannitol
Cat.No: T0414
Synonym: Mannite,Mannitol,D-甘露糖醇,Osmitrol
Target: Apoptosis, Dehydrogenase, Endogenous Metabolite
Desoxyrhaponticin
Cat.No: TJS0387
Synonym: 去氧土大黄苷,Deoxyrhapontin,脱氧土大黄苷,Deoxyrhaponticin
Target: Apoptosis, Fatty Acid Synthase
Dimethyl phthalate
Cat.No: T3746
Synonym: 邻苯二甲酸二甲酯,Solvanom,Avolin,Fermine,避蚊酯
Target: Others
H-Abu-OH
Cat.No: T5306
Synonym: L-2-氨基丁酸,L-Aminobutyric Acid,L-α-amino-n-Butyric acid,L(+)-2-Aminobutyric acid
Target: Others, Endogenous Metabolite
3-Methyl-L-histidine
Cat.No: T8274
Synonym:
Target: Endogenous Metabolite
Potassium 1H-indol-3-yl sulfate
Cat.No: T4938
Synonym: 硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate
Target: AhR, Endogenous Metabolite
Glycerol
Cat.No: T4776
Synonym: Glycerin,甘油
Target: Endogenous Metabolite
Phaseolin
Cat.No: T21261
Synonym:
Target:
FR-198248
Cat.No: T27380
Synonym:
Target: Others
trans-Psoralenoside
Cat.No: TN7367
Synonym:
Target: Others
Epsilon-(gamma-glutamyl)-lysine
Cat.No: T39168
Synonym: Epsilon-(gamma-glutamyl)-lysine,γ-Glu-ε-Lys,H-Glu(H-Lys-OH)-OH
Target: Others
Gochnatiolide A
Cat.No: T82273
Synonym:
Target:
Lysophosphatidylcholine 18:2
Cat.No: T36791
Synonym:
Target: Others
Lentztrehalose B
Cat.No: TN7284
Synonym:
Target: Others
Phenyl sulfate
Cat.No: T77988
Synonym: Phenyl hydrogen sulfate
Target: Endogenous Metabolite
Galegine hydrochloride
Cat.No: T35532
Synonym:
Target: Others
Lyso-Globotriaosylceramide (d18:1)
Cat.No: T37291
Synonym: Lyso-Globotriaosylceramide (d18:1)
Target: Others
Ergosterol peroxide
Cat.No: TMA1743
Synonym:
Target: ERK, VEGFR, p38 MAPK, Wnt/beta-catenin, Akt, JAK, CDK, JNK, STAT, Antifection
Harzianum A
Cat.No: T75461
Synonym:
Target: Others
Lentztrehalose A
Cat.No: TN7283
Synonym: (+)-Lentztrehalose A
Target: Others
OAT1/3-IN-1
Cat.No: T81630
Synonym:
Target:
3-O-trans-p-Coumaroyltormentic acid
Cat.No: TN2977
Synonym:
Target: Caspase, Antifection
Cat. No. Product Name Species Expression System
TMPY-01050 Cadherin 6/CDH6 Protein, Human, Recombinant (His)

CAD6,cadherin 6, type 2, K-cadherin (fetal kidney),...

Human HEK293 Cells
Cadherin 6/CDH6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68 kDa and the accession number is P55285-1.
TMPY-00663 Alkaline Phosphatase/ALPL Protein, Human, Recombinant (His)

alkaline phosphatase, liver/bone/kidney,TNSALP,AP-T...

Human HEK293 Cells
Alkaline Phosphatase/ALPL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is A0A024RAB4.
TMPJ-00385 CDH6 Protein, Human, Recombinant (hFc)

K-Cadherin,Cadherin-6,CDH6,Kidney Cadherin

Human HEK293 Cells
Cadherin-6 (CDH6) is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular r...
TMPH-01746 NOX4 Protein, Human, Recombinant (E. coli, His)

Kidney superoxide-producing NADPH oxidase,NOX4,NADP...

Human E. coli
NOX4 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.8 kDa and the accession number is Q9NPH5.
TMPH-01745 NOX4 Protein, Human, Recombinant (Cell-Free, His)

NOX4,Kidney oxidase-1,Renal NAD(P)H-oxidase,Kid...

Human E. coli
NOX4 Protein, Human, Recombinant (Cell-Free, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 69.8?kDa and the accession number is Q9NPH5.
TMPY-05347 Cadherin 6/CDH6 Protein, Cynomolgus, Recombinant (His)

cadherin 6, type 2, K-cadherin (fetal kidney)

Cynomolgus HEK293 Cells
Cadherin 6/CDH6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 67.5 kDa and the accession number is XP_005556691.1.
TMPY-00311 Cadherin 6/CDH6 Protein, Rat, Recombinant (His)

cadherin 6, type 2, K-cadherin (fetal kidney)

Rat HEK293 Cells
Cadherin 6/CDH6 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 67.9 kDa and the accession number is A6KJN4.
TMPJ-01303 Collectin-11 Protein, Human, Recombinant (His)

Collectin-11,COLEC11,CL-K1,Collectin Kidney Protein...

Human HEK293 Cells
Collectin-11 is a secreted protein that belongs to the COLEC10/COLEC11 family. Collectin-11 contains one C-type lectin domain and one collagen-like domain. Collectins play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. Collectin-11 binds to various sugars including fucose and mannose, but does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. It has a higher affinity for fucose compa...
TMPJ-00475 Kallikrein 1/KLK1 Protein, Human, Recombinant (aa 19-262, His)

Tissue Kallikrein,Kidney/Pancreas/Salivary Gland Ka...

Human HEK293 Cells
Kallikrein-1 (KLK1) is a member of human tissue Kallikrein family. Human KLK1 precursor contains a singal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262). The function of KLK1 is to cleave Kininogen in order to release the vasoactive Kinin peptide (Lysyl-Bradykinin or Bradykinin). The Kinin peptide controls blood pressure reduction, vasodilation, smooth muscle relaxation and contraction, pain induction and inflammation. KLK1 also plays ...
TMPY-00594 Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (hFc)

Akp-2,TNSALP,TNAP,alkaline phosphatase, liver/bone/kidne...

Mouse HEK293 Cells
Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 80.3 kDa and the accession number is B7XGA6.
TMPY-00446 Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (His)

TNSALP,Akp2,alkaline phosphatase, liver/bone/kidney...

Mouse HEK293 Cells
Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is B7XGA6.
TMPH-01887 Polycystin-1 Protein, Human, Recombinant (His)

Autosomal dominant polycystic kidney disease 1 prot...

Human E. coli
Polycystin-1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 69.3 kDa and the accession number is P98161.
TMPY-02931 Cadherin 6/CDH6 Protein, Mouse, Recombinant (His)

cadherin-6,cad6,cadherin 6, type 2, K-cadherin (fetal ki...

Mouse HEK293 Cells
Cadherin 6/CDH6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68.7 kDa and the accession number is P97326.
TMPH-02802 Napsin-A/NAPSA Protein, Mouse, Recombinant (His)

Napsa,Kidney-derived aspartic protease-like protein...

Mouse E. coli
May be involved in processing of pneumocyte surfactant precursors. Napsin-A/NAPSA Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 40.5 kDa and the accession number is O09043.
TMPJ-01058 ARG2 Protein, Human, Recombinant (His)

ARG2,Kidney-type arginase,Type II arginase,Arginase...

Human E. coli
Arginase-2 (ARG2) is a member of the arginase family. Arginase is a manganese-containing enzyme which catalyzes the hydrolysis of arginine to ornithine and urea. ARG2 is highly expressed in kidney and prostate, not founded in the liver, heart and pancreas. ARG2 has been implicated in the regulation of the arginine/ornithine concentrations in the cell. ARG2 may take part in the regulation of extra-urea cycle arginine metabolism and in down-regulation of nitric oxide synthesis. The extrahepatic ar...
TMPH-02526 Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)

Arginase II,Kidney-type arginase,Type II arginase,A...

Mouse E. coli
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium....
TMPJ-00423 TIM-1/KIM-1/HAVCR1 Protein, Mouse, Recombinant (His)

Hepatitis A virus cellular receptor 1 homolog,HAVcr-1,T cell...

Mouse HEK293 Cells
TIM-1/KIM-1/HAVCR belongs to the immunoglobulin superfamily that cosisits 305 amino acid (aa). It is expressed by stimulated T-cells. TIM-1/KIM-1/HAVCR may play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. And may have a role in kidney injury and repair. Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hypera...
TMPH-00952 Aquaporin-1/AQP1 Protein, Human, Recombinant (His & SUMO)

AQP1,AQP-1,Urine water channel,Aquaporin-1,Aquaporin-CHIP,CH...

Human E. coli
Aquaporin-1/AQP1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPY-02956 Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)

APOL1,apolipoprotein L1,APOL,FSGS4,APOL-I,APO-L

Human Baculovirus Insect Cells
APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney, and brain. APOL1 belongs to the apolipoprotein L family. It may play a role in lipid exchange and transport throughout the body. It may also participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomer...
TMPJ-00235 TPO Protein, Human, Recombinant (His)

Megakaryocyte growth and development factor,C-mpl ligand,Thr...

Human HEK293 Cells
Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physi...
TMPJ-00842 FGF-2 Protein, Rat, Recombinant

bFGF,Heparin-Binding Growth Factor 2,FGFB,Fibroblast Growth ...

Rat E. coli
FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. They act on several cell types to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects, and tissue repair. FGF-basic is a non-glycosylated heparin binding g...
TMPJ-00261 TGF beta 2 Protein, Mouse/Rat, Recombinant

transforming growth factor β-2,BSC-1 cell growth inhibitor,G...

Mouse,Rat HEK293 Cells
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n...
TMPY-02707 PAH Protein, Human, Recombinant (415 Asn/Asp, His)

phenylalanine hydroxylase,PH,PKU1,PKU

Human Baculovirus Insect Cells
PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding sites for phenylalanine and to constitute an "inhibitory" domain that regulates the activity of a catalytic domain in the C-terminal portion of the molecule. In humans, PAH is expressed both in the liver and the kidney, and there is some indication that it may be differentially reg...
TMPY-01085 VLDLR Protein, Human, Recombinant (His)

VLDLRCH,CAMRQ1,CHRMQ1,very low density lipoprotein receptor,...

Human HEK293 Cells
The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar sdomain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is ...
TMPJ-00412 VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)

Vascular endothelial growth factor receptor 1,Vascular perme...

Human HEK293 Cells
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas...
TMPJ-00677 TGOLN2 Protein, Human, Recombinant (His)

Trans-Golgi network protein TGN51,TGN38 homolog,TGN51,TGN46,...

Human HEK293 Cells
This protein may be involved in regulating membrane traffic to and from trans-Golgi network. Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells.
TMPH-02119 SLC5A2 Protein, Human, Recombinant (His & Myc)

Solute carrier family 5 member 2,Low affinity sodium-glucose...

Human E. coli
Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
TMPK-00751 FSTL3 Protein, Human, Recombinant (His)

FSTL3,FLRGFSRP,Follistatin-like 3,FLRG

Human HEK293 Cells
Follistatin-like 3 (FSTL3) is a novel cytokine that regulates insulin sensitivity and counteracts activin/myostatin signalling. In the present study, regulation of FSTL3 in renal dysfunction was investigated in both human chronic kidney disease (CKD) and acute kidney dysfunction (AKD). Furthermore, mFSTL3 expression was analysed in insulin-sensitive tissues in a mouse model of CKD.
TMPK-00546 TIM-1/KIM-1/HAVCR1 Protein, Cynomolgus, Recombinant (His)

CD365,HAVCR1,KIM1,TIMD-1,TIM-1,KIM-1,HAVcr-1,TIM1,HAVCR,TIMD...

Cynomolgus HEK293 Cells
Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation. TIM-1/KIM-1/HAVCR1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 35.25 kDa and the accession number is ...
TMPJ-00656 SULT1C2 Protein, Human, Recombinant (His)

Sulfotransferase 1C1,humSULTC2,SULT1C1,Sulfotransferase 1C2,...

Human E. coli
Sulfotransferase 1C2 (SULT1C2) is a cytosolic enzyme member of the Sulfotransferase 1 family. Human SULT1C2 is primarily expressed in the adult stomach, kidney and thyroid gland, and in the fetal kidney and liver. SULT1C2 catalyzes the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. SULT1C2 may be involved in the activation of carcinogenic hyroxylamines. It shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).
TMPK-01139 TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 21-295, His)

KIM1,TIM-1,HAVCR-1,KIM-1,TIM,TIM1,TIMD1,HAVCR,CD365,TIMD-1,H...

Human HEK293 Cells
Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation. TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 21-295, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 30.58 kDa and the accession numb...
TMPK-00765 Pentraxin 2/SAP Protein, Human, Recombinant (hFc)

PTX2,SAP,Pentraxin 2,MGC88159,APCS

Human HEK293 Cells
Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune plasma protein whose circulating level is decreased in chronic human fibrotic recombinant human PTX-2 (rhPTX-2) retards progression of chronic kidney disease in Col4a3 mutant mice with Alport syndrome, reducing blood markers of kidney failure, enhancing lifespan by 20%, and improving histological signs of disease. diseases. Pentraxin 2/SAP Protein, Human, Recombinant (hFc) ...
TMPK-00113 Pentraxin 2/SAP Protein, Mouse, Recombinant (hFc)

APCS,MGC88159,SAP,Pentraxin 2,PTX2

Mouse HEK293 Cells
Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune plasma protein whose circulating level is decreased in chronic human fibrotic recombinant human PTX-2 (rhPTX-2) retards progression of chronic kidney disease in Col4a3 mutant mice with Alport syndrome, reducing blood markers of kidney failure, enhancing lifespan by 20%, and improving histological signs of disease. diseases. Pentraxin 2/SAP Protein, Mouse, Recombinant (hFc) ...
TMPJ-01185 SULT1C4 Protein, Human, Recombinant (His)

SULT1C4,Sulfotransferase,hCG_27301,SULT1C2

Human E. coli
Human Sulfotransferase (SULT1C4) is an enzyme that in humans is encoded by the SULT1C4 gene, belongs to the sulfotransferase 1 family. SULT1C4 is expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord. Sulfotransferase utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. It shows activity towards p-nitrophenol and N-hy...
TMPH-02667 Galactosylceramidase Protein, Mouse, Recombinant

Galactocerebroside beta-galactosidase,Galactocerebrosidase,G...

Mouse E. coli
Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
TMPH-01753 Netrin-4/NTN4 Protein, Human, Recombinant (GST & His & Myc)

Netrin-4,Beta-netrin,Hepar-derived netrin-like protein,NTN4

Human E. coli
May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants. Netrin-4/NTN4 Protein, Human, Recombinant (GST & His & Myc) is expressed in E. coli expression system with N-10xHis-GST and C-Myc tag. The predicted molecular weight is 58.9 kDa and the accession number is Q9HB63.
TMPH-03269 COMMD5 Protein, Rat, Recombinant (His & Myc)

COMM domain-containing protein 5,COMMD5,Hypertension-related...

Rat E. coli
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
TMPJ-01319 TINAGL1 Protein, Human, Recombinant (His)

LCN7,Tubulointerstitial nephritis antigen-like (TINAGL1),Oxi...

Human HEK293 Cells
TINAGL1 is a secreted protein and contains one SMB (somatomedin-B) domain. TINAGL1 is expressed in aorta, lymph nodes, heart, bone marrow, placenta, lung, kidney, skeletal muscle, pancreas, thyroid, adrenal gland and so on. TINAGL1 may be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells.
TMPY-00140 ABP1/AOC1 Protein, Human, Recombinant (His)

amine oxidase, copper containing 1,DAO,ABP1,ABP,KAO,DAO1

Human HEK293 Cells
Amine oxidase copper-containing 1 (AOC1; formerly known as amiloride-binding protein 1) is a secreted glycoprotein that catalyzes the degradation of putrescine and histamine. Polyamines and their diamine precursor putrescine are ubiquitous to all organisms and fulfill pivotal functions in cell growth and proliferation. That the Wilms tumor protein, WT1, which is necessary for normal kidney development, activates transcription of the AOC1 gene. Expression of a firefly luciferase reporter under co...
TMPJ-00082 NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc)

Lipocalin-2,SV-40-induced 24P3 protein,Siderocalin LCN2,LCN2...

Mouse HEK293 Cells
Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes with matrix metalloproteinase-9 (MMP-9) through disulfide bonds. Similar to other lipocalin family members, Lipocalin-2 is involved in diverse cellular processes, including the transport of small hydrophobic molecules, protection of MMP-9 from proteolytic degradation, and cell sig...
TMPH-01751 Nephrin/NPHS1 Protein, Human, Recombinant (His)

Nephrin,Renal glomerulus-specific cell adhesion receptor,NPH...

Human E. coli
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion. Nephrin/NPHS1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.1 kDa and the accession number is O60500.
TMPJ-00984 INPP1 Protein, Human, Recombinant (His)

IPP,IPPase,Inositol Polyphosphate 1-Phosphatase,INPP1

Human HEK293 Cells
Inositol Polyphosphate 1-Phosphatase (INPP1) is a member of the inositol monophosphatase family. INPP1 is widely expressed in tissues, with highest expression levels observed in the pancreas and kidney. INPP1 is inhibited by Li+. Removing the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. INPP1 is involved in signal transduction and phosphatidylinositol signaling pathway.
TMPJ-00273 IGSF11 Protein, Human, Recombinant (hFc)

CXADRL1,BT-IgSF,CT119,Igsf13,VSIG3

Human HEK293 Cells
Immunoglobulin superfamily member 11(IGSF11) is abundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle.IGSF11 functions as a cell adhesion molecule through homophilic interaction and can also stimulates cell growth.IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions.
TMPH-01747 FDXR Protein, Human, Recombinant (His & SUMO)

Ferredoxin--NADP(+) reductase,NADPH:adrenodoxin oxidoreducta...

Human E. coli
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. FDXR Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 61.6 kDa and the accession number is P22570.
TMPJ-01298 PRADC1 Protein, Human, Recombinant (His)

Protease-associated domain-containing protein of 21 kDa,Prot...

Human HEK293 Cells
PRADC1, also known as C2orf7 or PAP21, is short for Protease-associated domain-containing protein 1. It is a 188 aa. with a 21 aa. signal, and the 171 located Asn can be glycosylated. PRADC1 has two mutagenesis which are N121Q and N171Q. This protein is secreted and highly expressed in skeletal muscle, heart and liver. It is expressed at intermediate level in kidney.
TMPJ-00876 FAH Protein, Human, Recombinant (His)

Fumarylacetoacetate Hydrolase,β-Diketonase,FAH,FAA,Fumarylac...

Human HEK293 Cells
Fumarylacetoacetase belongs to the FAH family. Fumarylacetoacetase is primary expressed in liver and kidney. It exists as a homodimer and catalyzes the hydrolysis of 4-fumarylacetoacetate into fumarate and acetoacetate. Defects in Fumarylacetoacetase cause tyrosinemia type 1, which is congenital metabolism defect characterized by elevated levels of tyrosine in the blood and urine, and hepatorenal manifestations. Typical features include renal tubular injury, self-mutilation, hepatic necrosis, ep...
TMPH-00287 Adrenodoxin reductase Protein, Bovine, Recombinant (E. coli, His)

Ferredoxin--NADP(+) reductase,ADXR,NADPH:adrenodoxin oxidore...

Bovine E. coli
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Adrenodoxin reductase Protein, Bovine, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 55.8 kDa and the accession number is ...
TMPH-02881 Renin-2 Protein, Mouse, Recombinant (His)

Ren2,Renin-2,Submandibular gland renin,Angiotensinogenase

Mouse E. coli
Renin is a highly specific endopeptidase, related to pepsin, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Its function in the salivary gland is not understood. Renin-2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.0 kDa and the accession number ...
TMPH-00288 Adrenodoxin reductase Protein, Bovine, Recombinant (His)

Ferredoxin reductase,Adrenodoxin reductase,Ferredoxin--NADP(...

Bovine P. pastoris (Yeast)
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Adrenodoxin reductase Protein, Bovine, Recombinant (His) is expressed in yeast with N-10xHis tag. The predicted molecular weight is 52.8 kDa and the accession number is P08165.
TMPJ-00479 KHK Protein, Human, Recombinant (His)

KHK,Hepatic fructokinase,Ketohexokinase

Human HEK293 Cells
Ketohexokinase, also known as Hepatic fructokinase, is a member of the carbohydrate kinase PfkB family. It exits as a homodimer and most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.This enzyme catalyzes conversion of fructose to fructose-1-phosphate. It is the first enzyme with a specialized pathway that catabolizes dietary fructose. Defects in KHK are the cause of fructosuria.
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重组蛋白

Cadherin 6/CDH6 Protein, Human, Recombinant (His)
Cat.No: TMPY-01050
Species: Human
Expression System: HEK293 Cells
Alkaline Phosphatase/ALPL Protein, Human, Recombinant (His)
Cat.No: TMPY-00663
Species: Human
Expression System: HEK293 Cells
CDH6 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00385
Species: Human
Expression System: HEK293 Cells
NOX4 Protein, Human, Recombinant (E. coli, His)
Cat.No: TMPH-01746
Species: Human
Expression System: E. coli
NOX4 Protein, Human, Recombinant (Cell-Free, His)
Cat.No: TMPH-01745
Species: Human
Expression System: E. coli
Cadherin 6/CDH6 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPY-05347
Species: Cynomolgus
Expression System: HEK293 Cells
Cadherin 6/CDH6 Protein, Rat, Recombinant (His)
Cat.No: TMPY-00311
Species: Rat
Expression System: HEK293 Cells
Collectin-11 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01303
Species: Human
Expression System: HEK293 Cells
Kallikrein 1/KLK1 Protein, Human, Recombinant (aa 19-262, His)
Cat.No: TMPJ-00475
Species: Human
Expression System: HEK293 Cells
Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-00594
Species: Mouse
Expression System: HEK293 Cells
Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (His)
Cat.No: TMPY-00446
Species: Mouse
Expression System: HEK293 Cells
Polycystin-1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01887
Species: Human
Expression System: E. coli
Cadherin 6/CDH6 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02931
Species: Mouse
Expression System: HEK293 Cells
Napsin-A/NAPSA Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02802
Species: Mouse
Expression System: E. coli
ARG2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01058
Species: Human
Expression System: E. coli
Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02526
Species: Mouse
Expression System: E. coli
TIM-1/KIM-1/HAVCR1 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00423
Species: Mouse
Expression System: HEK293 Cells
Aquaporin-1/AQP1 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-00952
Species: Human
Expression System: E. coli
Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02956
Species: Human
Expression System: Baculovirus Insect Cells
TPO Protein, Human, Recombinant (His)
Cat.No: TMPJ-00235
Species: Human
Expression System: HEK293 Cells
FGF-2 Protein, Rat, Recombinant
Cat.No: TMPJ-00842
Species: Rat
Expression System: E. coli
TGF beta 2 Protein, Mouse/Rat, Recombinant
Cat.No: TMPJ-00261
Species: Mouse,Rat
Expression System: HEK293 Cells
PAH Protein, Human, Recombinant (415 Asn/Asp, His)
Cat.No: TMPY-02707
Species: Human
Expression System: Baculovirus Insect Cells
VLDLR Protein, Human, Recombinant (His)
Cat.No: TMPY-01085
Species: Human
Expression System: HEK293 Cells
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00412
Species: Human
Expression System: HEK293 Cells
TGOLN2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00677
Species: Human
Expression System: HEK293 Cells
SLC5A2 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-02119
Species: Human
Expression System: E. coli
FSTL3 Protein, Human, Recombinant (His)
Cat.No: TMPK-00751
Species: Human
Expression System: HEK293 Cells
TIM-1/KIM-1/HAVCR1 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00546
Species: Cynomolgus
Expression System: HEK293 Cells
SULT1C2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00656
Species: Human
Expression System: E. coli
TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 21-295, His)
Cat.No: TMPK-01139
Species: Human
Expression System: HEK293 Cells
Pentraxin 2/SAP Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00765
Species: Human
Expression System: HEK293 Cells
Pentraxin 2/SAP Protein, Mouse, Recombinant (hFc)
Cat.No: TMPK-00113
Species: Mouse
Expression System: HEK293 Cells
SULT1C4 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01185
Species: Human
Expression System: E. coli
Galactosylceramidase Protein, Mouse, Recombinant
Cat.No: TMPH-02667
Species: Mouse
Expression System: E. coli
Netrin-4/NTN4 Protein, Human, Recombinant (GST & His & Myc)
Cat.No: TMPH-01753
Species: Human
Expression System: E. coli
COMMD5 Protein, Rat, Recombinant (His & Myc)
Cat.No: TMPH-03269
Species: Rat
Expression System: E. coli
TINAGL1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01319
Species: Human
Expression System: HEK293 Cells
ABP1/AOC1 Protein, Human, Recombinant (His)
Cat.No: TMPY-00140
Species: Human
Expression System: HEK293 Cells
NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00082
Species: Mouse
Expression System: HEK293 Cells
Nephrin/NPHS1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01751
Species: Human
Expression System: E. coli
INPP1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00984
Species: Human
Expression System: HEK293 Cells
IGSF11 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00273
Species: Human
Expression System: HEK293 Cells
FDXR Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01747
Species: Human
Expression System: E. coli
PRADC1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01298
Species: Human
Expression System: HEK293 Cells
FAH Protein, Human, Recombinant (His)
Cat.No: TMPJ-00876
Species: Human
Expression System: HEK293 Cells
Adrenodoxin reductase Protein, Bovine, Recombinant (E. coli, His)
Cat.No: TMPH-00287
Species: Bovine
Expression System: E. coli
Renin-2 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02881
Species: Mouse
Expression System: E. coli
Adrenodoxin reductase Protein, Bovine, Recombinant (His)
Cat.No: TMPH-00288
Species: Bovine
Expression System: P. pastoris (Yeast)
KHK Protein, Human, Recombinant (His)
Cat.No: TMPJ-00479
Species: Human
Expression System: HEK293 Cells
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Cat. No. Product Name Target Signaling Pathways
TMID-0162 Creatinine-d5

Creatinine-d5 是 Creatinine 的氘代化合物。Creatinine 的 CAS 号为 60-27-5。Creatinine 由肌肉中磷酸肌酸分解产生。
T36384 DL-Tyrosine-13C9,15N

L-Tyrosine-13C9,15N

L-Tyrosine-13C9,15N is intended for use as an internal standard for the quantification of L-tyrosine by GC- or LC-MS. L-Tyrosine is a non-essential amino acid.1It is produced by hydroxylation of phenylalanine by phenylalanine hydroxylase but can also be obtained from dietary sources or degradation of endogenous proteins, resulting in L-tyrosine release.1,2L-Tyrosine is a precursor in the biosynthesis of catecholamine neurotransmitters, melanins, and thyroid hormones.3Plasma, skeletal muscle, and...
T35778 Ochratoxin A-13C20

Ochratoxin A-13C20

Ochratoxin A-13C20is intended for use as an internal standard for the quantification of ochratoxin A by GC- or LC-MS. Ochratoxin A is a mycotoxin that has been found inAspergillusandPenicillium.1It increases lipid peroxide levels and the number of apoptotic cells, as well as reduces superoxide dismutase activity in rat kidney when administered at a dose of 120 μg/kg.2Topical application of ochratoxin A (80 μg/mouse) induces DNA damage, cell cycle arrest at the G0/G1phase, and apoptosis in mouse ...
T35520 Aflatoxin G1-13C17

Aflatoxin G1-13C17

Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to ducklings (LD50= 1.18 mg/kg).2It induces hepatocellular carcinoma tumor formation and lethality in rats when administered at doses of 1.4 and 3 mg/animal, respectively. Aflatoxin G1also inhibits liver and kidney succinate dehydrogenase and fumarase, as well as kidney cytochrome oxidase...
T71328 Theobromine-d6

Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium....
T69966 Roxadustat-d5

Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ...
TMIJ-0317 Nadolol-d9 (Mixture of Diastereomers)

Nadolol-d9 (Mixture of Diastereomers) 是 Nadolol 的氘代化合物。Nadolol 的 CAS 号为 42200-33-9。Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物,是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂,可用于高血压,心绞痛和血管性头痛的研究。
T36537 Nitrofurantoin-13C3

Nitrofurantoin-13C3

Nitrofurantoin-13C3is intended for use as an internal standard for the quantification of nitrofurantoin by GC- or LC-MS. Nitrofurantoin is a nitrofuran antibiotic.1In vivo, nitrofurantoin (25-100 mg/kg) reducesE. colireplication and abscess formation in the renal medulla of infected rats in a dose-dependent manner. It prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates ofP. mirabilis. Nitrofurantoin also prevents alkalization of urine, as well as ca...

同位素标记化合物

Creatinine-d5
Cat.No: TMID-0162
Synonym:
Target:
DL-Tyrosine-13C9,15N
Cat.No: T36384
Synonym: L-Tyrosine-13C9,15N
Target:
Ochratoxin A-13C20
Cat.No: T35778
Synonym: Ochratoxin A-13C20
Target:
Aflatoxin G1-13C17
Cat.No: T35520
Synonym: Aflatoxin G1-13C17
Target:
Theobromine-d6
Cat.No: T71328
Synonym:
Target:
Roxadustat-d5
Cat.No: T69966
Synonym:
Target:
Nadolol-d9 (Mixture of Diastereomers)
Cat.No: TMIJ-0317
Synonym:
Target:
Nitrofurantoin-13C3
Cat.No: T36537
Synonym: Nitrofurantoin-13C3
Target:
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