eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) is Elongation factor 1 subunit.eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in the brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in the brain, heart, and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes1.

在真核生物中存在两种形式的eEF1A，即eEF1A1和eEF1A2，它们在蛋白质合成中扮演相同的角色。eEF1A2被报道仅在大脑、心脏和骨骼肌中表达，而eEF1A1则被广泛表达。由染色体凝结障碍产生的四倍体细胞通过一种与半胱天冬酶依赖性凋亡不同的新型细胞死亡方式被清除。该细胞死亡与真核翻译延伸因子-1 a 1 (eEF1A1/EF-1a)表达的下调以及其mRNA在处理体（P体）中的积累相关。重要的是，外源eEF1A1的表达被证明能抑制该半胱天冬酶独立的细胞死亡，而在诱导针对eEF1A1的短发夹RNA表达后观察到类似的细胞死亡。