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Search Results for " hypertension "

Targets Recommended: RAAS

281

抑制剂 & 化合物

20

天然产物

5

化合物库

11

重组蛋白

18

同位素标记化合物

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Cat. No.	Product Name
L7110	抗高血压化合物库		678 compounds
	678 种高血压相关的小分子，用于高通量和高内涵筛选；
L7200	钙通道分子库		140 compounds
	140 种钙通道相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L1510	核受体化合物库		531 compounds
	531 个核受体作用化合物的独特集合，可用于高通量筛选和高内涵筛选；
L2560	代谢化合物库		2320 compounds
	2320 种代谢途径相关的化合物，可用于高通量和高内涵筛选。
L8500	HIF-1化合物库		1336 compounds
	1336 个HIF-1相关小分子的独特集合，可用于缺血性疾病、癌症等相关领域的药物开发和药理研究；

化合物库

抗高血压化合物库

Cat.No: L7110

Compounds: 678

钙通道分子库

Cat.No: L7200

Compounds: 140

核受体化合物库

Cat.No: L1510

Compounds: 531

代谢化合物库

Cat.No: L2560

Compounds: 2320

HIF-1化合物库

Cat.No: L8500

Compounds: 1336

Cat. No.	Product Name	Target	Signaling Pathways
T13865	Resorcinolnaphthalein	RAAS	Endocrinology/Hormones
	Resorcinolnaphthalein 是一种特异性的血管紧张素转换酶 2 激活剂，EC50=19.5 μM。Resorcinolnaphthalein 能够用于高血压和肾纤维化的研究
T12268	NTP42	Prostaglandin Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism
	NTP42 是血栓素 A2 (TXA2) 受体的拮抗剂，IC50为 3.278 nM，可用于肺动脉高压的相关研究。
T11339	Furegrelate sodium U-63557A	PPAR	DNA Damage/DNA Repair; Metabolism
	Furegrelate sodium (U-63557A) 是口服有效的、血栓素合酶选择性抑制剂，抑制人血小板微粒体血栓素 A2 (TxA2) 合酶的 IC50为 15 nM。它正在开发作为抗血小板药物。
T1484	Perindoprilat Perindoprilate,培哚普利	RAAS; MRP; AChR	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
	Perindoprilat (Perindoprilate) 是一种血管紧张素转换酶抑制剂。
T0114	Trichlormethiazide Naqua,Metahydrin,三氯噻嗪,Trichlormetazid	ATPase; Carbonic Anhydrase	Membrane transporter/Ion channel; Metabolism
	Trichlormethiazide (Naqua) 是一种口服具有活力的噻嗪类利尿剂，具有降压作用。它能够提高急性肾功能衰竭大鼠的尿量、Na 和 K 排泄，并有改善降低的肌酐清除率。
T8900	Seralutinib GB002	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Seralutinib (GB002) 是可吸入的PDGFRα 和 PDGFRβ激酶抑制剂，可用于研究肺动脉高压。
T14315	AR-9281 APAU	Epoxide Hydrolase	Metabolism
	AR-9281 (APAU) 是选择性的可溶性环氧化物水解酶抑制剂，可用于研究高血压和 2 型糖尿病。
T4316	ML365	Potassium Channel	Membrane transporter/Ion channel
	ML365 是有效的，选择性的双孔结构域钾通道TASK1/KCNK3抑制剂，IC50为 4 nM。它可用于检查 TASK1 通道的特定作用。
T1385	Amlodipine 氨氯地平,UK-48340	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Amlodipine (UK-48340) 是可口服的二氢吡啶钙通道阻滞剂，有抗心绞痛作用。它通过阻断电压依赖性的 L 型钙通道，从而抑制钙离子内流，用于高血压和癌症的研究。
T8372	VU0134992 VU 0134992	Potassium Channel	Membrane transporter/Ion channel
	VU 0134992 是一个亚型偏好的，口服有效的和选择性的内向整流钾通道 Kir4.1阻滞剂，IC50为 0.97 μM。在 -120 mV 时，VU0134992对同分 Kir4.1 比 Kir4.1/5.1 共分通道 (IC50=9 μM) 高出 9 倍的选择性。
T2561	Macitentan 马西替坦,ACT-064992	Apoptosis; Endothelin Receptor	Apoptosis; GPCR/G Protein
	Macitentan (ACT-064992) 是一种内皮素受体拮抗剂，用于治疗肺动脉高压。
T0231	Amlodipine Besylate Amlodipine benzenesulfonate,苯磺酸氨氯地平	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Amlodipine Besylate (Amlodipine benzenesulfonate) 是可口服的二氢吡啶钙通道阻滞剂，有抗心绞痛作用。它通过阻断电压依赖性的 L 型钙通道，从而抑制钙离子内流，用于高血压和癌症的研究。
T6595	Moexipril hydrochloride 莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Moexipril hydrochloride (Moexipril HCl) 是一种有口服活性的，不含巯基的血管紧张素转化酶抑制剂，可治疗高血压和充血性心力衰竭。
T1489	Fosinopril sodium SQ28555,福辛普利钠	RAAS	Endocrinology/Hormones
	Fosinopril sodium 是一种血管紧张素转换酶（ACE）抑制剂的前药，能够作用于高血压和慢性心力衰竭。
T1057	Azilsartan TAK-536,阿齐沙坦	RAAS	Endocrinology/Hormones
	Azilsartan (TAK-536) 是一种高活性的血管紧张素Ⅱ1型受体特异性拮抗剂(IC50:2.6 nM)。
T0119	Nitrendipine BAY-E-5009,Bayotensin,尼群地平	Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Nitrendipine (BAY-E-5009) 是 Nifedipine 的类似物，是一种钙通道阻滞剂，具有显着的血管扩张作用。它是一种有效的抗高血压药且不会降低肾小球滤过率，并且具有轻微的利钠作用。
T0287	Hexamethonium Bromide Gangliostat,溴化六甲铵,Simpatoblock,六甲溴铵,Hexamethonium Dibromide	Apoptosis; Dopamine Receptor; AChR	Apoptosis; GPCR/G Protein; Neuroscience
	Hexamethonium Bromide (Hexamethonium Dibromide) 是神经节中神经元型烟碱型 AChR 的特异性拮抗剂。在自发性高血压动物模型中，它能降低其交感神经活动和血压。
T13316	VU0134992 hydrochloride	Potassium Channel	Membrane transporter/Ion channel
	VU0134992 hydrochloride 是一个亚型偏好的，具有口服活性和选择性的内向整流钾通道Kir4.1阻滞剂，IC50为 0.97 μM。在 -120 mV 时，VU0134992 hydrochloride 对同分 Kir4.1 比 Kir4.1/5.1 共分通道 (IC50=9 μM) 高出 9 倍的选择性。
TP1929L1	Saralasin acetate(34273-10-4 free base)	RAAS	Endocrinology/Hormones
	Saralasin acetate(34273-10-4 free base) 是一种非选择性血管紧张素 II 拮抗剂。
T5329	Trandolapril	Angiotensin-converting Enzyme (ACE)	Metabolism
	Trandolapril 是 Trandolaprilat 的前体药物。Trandolapril 是一种口服血管紧张素转换酶抑制剂，在高血压和充血性心力衰竭及心肌梗死领域有研究价值。
T14782	Brilaroxazine RP5063	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Brilaroxazine (RP5063) 是一种有效的多模式多巴胺/5-HT 调节剂。 Brilaroxazine 是多巴胺 D2、D3 和 D4 受体、5-HT1A (Ki = 1.5 nM) 和 5-HT2A (Ki = 2.5 nM) 的部分激动剂，具有拮抗活性 5-HT2B 和 5-HT7 受体，Ki 分别为 0.19 nM 和 2.7 nM。 Brilaroxazine 可用于研究神经精神和神经系统疾病的认知障碍。
T1461	Candesartan CV 11974,坎地沙坦	RAAS	Endocrinology/Hormones
	Candesartan (CV 11974) 是一种血管紧张素II 受体拮抗剂(IC50:0.26 nM)。
T0386L	Ropivacaine LEA-103 HCl,罗哌卡因	Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Ropivacaine (LEA-103 HCl) 是有效的钠通道阻断剂，通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine 也是一种 K2P(双孔钾通道)TREK-1的抑制剂，在 COS-7 细胞膜上的 IC50值为 402.7 μM。Ropivacaine 可以用于神经性疼痛的缓解的相关研究。
T2141	Mecamylamine hydrochloride 盐酸美加明,Inversine,Mevasin	AChR	Neuroscience
	Mecamylamine hydrochloride (Mevasin) 是一种易穿过血脑屏障的烟碱拮抗剂，用作高血压的神经节阻滞剂，具有抗神经疾病作用。
T1275	Phentolamine mesylate Phentolamine methanesulfonate,甲磺酸酚妥拉明,Phentolamine mesilate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phentolamine mesylate (Phentolamine methanesulfonate) 是一种非选择性的、可逆的，具有口服活性的 α1 和 α2 肾上腺素能受体阻滞剂，能够扩张使血管，降低周围血管阻力。它可用于研究嗜铬细胞瘤相关的高血压，心力衰竭和勃起功能障碍。
T7714	Temocapil	Tyrosinase	Proteases/Proteasome
	Temocapil 是一种酪氨酸激酶抑制剂。
T0386	Ropivacaine hydrochloride 盐酸罗哌卡因,Ropivacaine monohydrochloride	Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Ropivacaine hydrochloride (Ropivacaine monohydrochloride) 是钠通道阻断剂，通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine hydrochloride 也是 K2P(双孔钾通道)TREK-1的抑制剂。在动物实验模型中，Ropivacaine hydrochloride 可用于神经性疼痛的缓解。
T20570	Labetalol Apo-Labetalol,Albetol,Trandate,Dilevalol,拉贝洛尔,Normodyne	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Labetalol (Apo-Labetalol) 是一种抗高血压药物，可用于心血管疾病的研究，如妊娠期高血压。它是一种口服具有活性的选择性 α1- 和非选择性 β-肾上腺素能受体 (adrenergic receptor) 竞争性拮抗剂。
T1158	Phenoxybenzamine hydrochloride 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl	CaMK; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phenoxybenzamine hydrochloride (NCI-c01661) 是一种选择性的 α-adrenoceptor 和 calmodulin 的抑制剂，是常用的抗高血压药。
T0083	Eplerenone Epoxymexrenone,CGP 30083,依普利酮,SC-66110	Glucocorticoid Receptor	Endocrinology/Hormones
	Eplerenone (CGP 30083) 是一种竞争性的、选择性的、具有口服活性的醛固酮 (aldosterone) 拮抗剂，IC50=138 nM。它对孕酮，雄激素，雌激素和糖皮质激素受体的亲和力低，可用于研究高血压和心肌梗死后的心力衰竭。
T3096	Canrenoate potassium 坎利酸钾,Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone	Glucocorticoid Receptor	Endocrinology/Hormones
	Canrenoate potassium (Soldactone) 是一种有效的竞争性盐皮质激素受体 (mineralocorticoid receptor) 拮抗剂，是一种释放 canrenone 的前药。它作为一种利尿剂，用于高血压的研究。
T1462	Captopril SQ 14225,甲巯丙脯酸,卡托普利,SQ-14534,SA333	RAAS	Endocrinology/Hormones
	Captopril (SA333) 是一种含巯基的，具有口服活性的血管紧张素转换酶(ACE)抑制剂，IC50=0.025 μM，广泛应用于高血压和充血性心力衰竭的研究。Captopril 也是NDM-1抑制剂，IC50=7.9 μM。
T1439	Lacidipine SN-305,拉西地平,GX-1048,GR-43659X	Apoptosis; Calcium Channel; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	Lacidipine (SN-305) 是一种L 型钙离子通道阻断剂。
T6340	Enalaprilat Dihydrate 依那普利拉二水合物,MK-422,MK-422 Dihydrate	RAAS; Autophagy	Autophagy; Endocrinology/Hormones
	Enalaprilat Dihydrate (MK-422 Dihydrate) 是一种有效的血管紧张素转化酶抑制剂，IC50为 1.94 nM。
T1520	Aliskiren hemifumarate 阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B	RAAS; Autophagy	Autophagy; Endocrinology/Hormones
	Aliskiren hemifumarate (CGP60536B) 一种可口服非肽肾素抑制剂，IC50为1.5 nM，具有抗高血压活性。
T2318	Sacubitril/Valsartan Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696	Apoptosis; RAAS; Neprilysin	Apoptosis; Endocrinology/Hormones; Metabolism
	Sacubitril/Valsartan (LCZ696)，以1:1摩尔比由Valsartan（一种ARB）和Sacubitril（AHU377）组成，为创新口服血管紧张素受体-脑啡肽酶（ARN）双重抑制剂，旨在治疗高血压与心力衰竭。其作用机制包括抑制炎症、氧化应激及细胞凋亡，有助于改善糖尿病心肌病。
T0154	Nebivolol hydrochloride R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824	Apoptosis; Adrenergic Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂，IC50为0.8 nM。
T6698	Temocapril hydrochloride CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利	RAAS	Endocrinology/Hormones
	Temocapril hydrochloride (CS-622 HCl) 是血管紧张素转化酶 (ACE) 抑制剂。Temocapril HCl 能够用于充血性心力衰竭、急性心肌梗死、高血压、胰岛素抵抗和肾脏疾病的研究。
T6645	Ropivacaine hydrochloride monohydrate Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,盐酸罗哌卡因,盐酸罗哌卡因一水合物,LEA-103 HCl	Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Ropivacaine hydrochloride monohydrate (LEA-103 HCl) 是钠通道阻断剂，通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine HCl monohydrate 也是 K2P(双孔钾通道)TREK-1的抑制剂。在动物实验模型中，Ropivacaine HCl monohydrate 可用于神经性疼痛的缓解。
T0487	Metoprolol tartrate 酒石酸美托洛尔,CGP 2175E	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Metoprolol tartrate 是一种心脏选择性β1肾上腺素阻断剂。
T3148	MK-571 sodium L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	MK-571 sodium (L-660711 sodium salt) 是一种可口服的选择性白三烯 D4受体拮抗剂，在豚鼠和人肺膜的 Ki 分别为0.22 和 2.1 nM。
T0143	Bisoprolol hemifumarate 富马酸比索洛尔,(±)-Bisoprolol hemifumarate,Bisoprolol fumarate,Bisoprolol hemifumarate salt,EMD33512,(±)-Bisoprolol (hemifumarate)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bisoprolol hemifumarate 是一种 β1 肾上腺素受体阻断剂。
T28759	Sesamodil Sesamodil fumarate,SD-3211,SD 3211,SD3211,DS-4823	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Sesamodil（SD 3211）是一种新型钙拮抗剂，可用于研究高血压。
T30219	AVE-9488 AVE 9488,AVE9488	NOS; NO Synthase	Immunology/Inflammation
	AVE-9488 是一种新型的内皮 NO 合酶（eNOS）增强剂，可上调eNOS表达，诱导 NO 的产生，可改善门静脉高压症。
T27087	Cronidipine LF 2.0254,LF-20254,LF20254,LF 20254	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Cronidipine (LF 20254) 是一种钙通道拮抗剂，可用于治疗高血压和心肌缺血。
T20024	cis-Tadalafil Tadalafil EP Impurity A,cis-IC-351,(6R ,12aS)-Tadalafil,(-)-Tadalafil (6R ,12aS) diastereomer	PDE	Metabolism
	cis-Tadalafil (cis-IC-351) 是一种有效的 PDE5 抑制剂，IC50 值为 0.09 μM，可用于研究动脉高压。
T1518	Olmesartan Medoxomil 奥美沙坦酯,CS 866,Benicar	RAAS	Endocrinology/Hormones
	Olmesartan Medoxomil (Benicar) 是血管紧张素 (angiotensin AT1) 受体选择性抑制剂(IC50:66.2 μM)。
T68036	Carprazidil	Others	Others
	Carprazidil 是一种强效的血管扩张剂，可用于治疗严重高血压和轻度心力衰竭。
T25226	Ceronapril Ceronaprilum,SQ 29852,SQ-29852,SQ29852	RAAS	Endocrinology/Hormones
	Ceronapril (SQ 29852) 是一种具有口服活性和高效性的血管紧张素转换酶 (ACE) 抑制剂(IC50 : 36 nM),可用于研究痴呆和高血压。
T0782	Benzthiazide Aquatag,苄噻嗪,Lemazide,Dihydrex	Carbonic Anhydrase	Metabolism
	Benzthiazide (Lemazide) 是长效利尿剂及抗高血压剂。它也是碳酸酐酶 9 的抑制剂，他对 CA9，CA2 和 CA1 的 Ki 分别为 8.0，8.8 和 10 nM。它对肿瘤细胞增殖具有抑制作用。

化合物

Resorcinolnaphthalein

Cat.No: T13865

Target: RAAS

Cat.No: T12268

Target: Prostaglandin Receptor, PPAR

Furegrelate sodium

Cat.No: T11339

Synonym: U-63557A

Target: PPAR

Cat.No: T1484

Synonym: Perindoprilate,培哚普利

Target: RAAS, MRP, AChR

Trichlormethiazide

Cat.No: T0114

Synonym: Naqua,Metahydrin,三氯噻嗪,Trichlormetazid

Target: ATPase, Carbonic Anhydrase

Cat.No: T8900

Synonym: GB002

Target: PDGFR

Cat.No: T14315

Synonym: APAU

Target: Epoxide Hydrolase

Cat.No: T4316

Target: Potassium Channel

Cat.No: T1385

Synonym: 氨氯地平,UK-48340

Target: Calcium Channel

Cat.No: T8372

Synonym: VU 0134992

Target: Potassium Channel

Cat.No: T2561

Synonym: 马西替坦,ACT-064992

Target: Apoptosis, Endothelin Receptor

Amlodipine Besylate

Cat.No: T0231

Synonym: Amlodipine benzenesulfonate,苯磺酸氨氯地平

Target: Calcium Channel

Moexipril hydrochloride

Cat.No: T6595

Synonym: 莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925

Target: Apoptosis, RAAS

Fosinopril sodium

Cat.No: T1489

Synonym: SQ28555,福辛普利钠

Target: RAAS

Cat.No: T1057

Synonym: TAK-536,阿齐沙坦

Target: RAAS

Cat.No: T0119

Synonym: BAY-E-5009,Bayotensin,尼群地平

Target: Calcium Channel, Autophagy

Hexamethonium Bromide

Cat.No: T0287

Synonym: Gangliostat,溴化六甲铵,Simpatoblock,六甲溴铵,Hexamethonium Dibromide

Target: Apoptosis, Dopamine Receptor, AChR

VU0134992 hydrochloride

Cat.No: T13316

Target: Potassium Channel

Saralasin acetate(34273-10-4 free base)

Cat.No: TP1929L1

Target: RAAS

Cat.No: T5329

Target: Angiotensin-converting Enzyme (ACE)

Cat.No: T14782

Synonym: RP5063

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T1461

Synonym: CV 11974,坎地沙坦

Target: RAAS

Cat.No: T0386L

Synonym: LEA-103 HCl,罗哌卡因

Target: Potassium Channel, Sodium Channel

Mecamylamine hydrochloride

Cat.No: T2141

Synonym: 盐酸美加明,Inversine,Mevasin

Target: AChR

Phentolamine mesylate

Cat.No: T1275

Synonym: Phentolamine methanesulfonate,甲磺酸酚妥拉明,Phentolamine mesilate

Target: Adrenergic Receptor

Cat.No: T7714

Target: Tyrosinase

Ropivacaine hydrochloride

Cat.No: T0386

Synonym: 盐酸罗哌卡因,Ropivacaine monohydrochloride

Target: Potassium Channel, Sodium Channel

Cat.No: T20570

Synonym: Apo-Labetalol,Albetol,Trandate,Dilevalol,拉贝洛尔,Normodyne

Target: Adrenergic Receptor

Phenoxybenzamine hydrochloride

Cat.No: T1158

Synonym: 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl

Target: CaMK, Adrenergic Receptor

Cat.No: T0083

Synonym: Epoxymexrenone,CGP 30083,依普利酮,SC-66110

Target: Glucocorticoid Receptor

Canrenoate potassium

Cat.No: T3096

Synonym: 坎利酸钾,Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone

Target: Glucocorticoid Receptor

Cat.No: T1462

Synonym: SQ 14225,甲巯丙脯酸,卡托普利,SQ-14534,SA333

Target: RAAS

Cat.No: T1439

Synonym: SN-305,拉西地平,GX-1048,GR-43659X

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species

Enalaprilat Dihydrate

Cat.No: T6340

Synonym: 依那普利拉二水合物,MK-422,MK-422 Dihydrate

Target: RAAS, Autophagy

Aliskiren hemifumarate

Cat.No: T1520

Synonym: 阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B

Target: RAAS, Autophagy

Sacubitril/Valsartan

Cat.No: T2318

Synonym: Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696

Target: Apoptosis, RAAS, Neprilysin

Nebivolol hydrochloride

Cat.No: T0154

Synonym: R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824

Target: Apoptosis, Adrenergic Receptor

Temocapril hydrochloride

Cat.No: T6698

Synonym: CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利

Target: RAAS

Ropivacaine hydrochloride monohydrate

Cat.No: T6645

Synonym: Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,盐酸罗哌卡因,盐酸罗哌卡因一水合物,LEA-103 HCl

Target: Potassium Channel, Sodium Channel

Metoprolol tartrate

Cat.No: T0487

Synonym: 酒石酸美托洛尔,CGP 2175E

Target: Adrenergic Receptor

Cat.No: T3148

Synonym: L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid

Target: Leukotriene Receptor, LTR

Bisoprolol hemifumarate

Cat.No: T0143

Synonym: 富马酸比索洛尔,(±)-Bisoprolol hemifumarate,Bisoprolol fumarate,Bisoprolol hemifumarate salt,EMD33512,(±)-Bisoprolol (hemifumarate)

Target: Adrenergic Receptor

Cat.No: T28759

Synonym: Sesamodil fumarate,SD-3211,SD 3211,SD3211,DS-4823

Target: Calcium Channel

Cat.No: T30219

Synonym: AVE 9488,AVE9488

Target: NOS, NO Synthase

Cat.No: T27087

Synonym: LF 2.0254,LF-20254,LF20254,LF 20254

Target: Calcium Channel

Cat.No: T20024

Synonym: Tadalafil EP Impurity A,cis-IC-351,(6R ,12aS)-Tadalafil,(-)-Tadalafil (6R ,12aS) diastereomer

Target: PDE

Olmesartan Medoxomil

Cat.No: T1518

Synonym: 奥美沙坦酯,CS 866,Benicar

Target: RAAS

Cat.No: T68036

Target: Others

Cat.No: T25226

Synonym: Ceronaprilum,SQ 29852,SQ-29852,SQ29852

Target: RAAS

Cat.No: T0782

Synonym: Aquatag,苄噻嗪,Lemazide,Dihydrex

Target: Carbonic Anhydrase

Cat. No.	Product Name	Target	Signaling Pathways
T3055	Liensinine Perchlorate	Apoptosis; Others	Apoptosis; Others
	Liensinine Perchlorate 是元莲的成分，可诱导结直肠癌细胞凋亡，具有抗高血压和抗癌活性。
TN1416	Ayanin	IL Receptor; P450; PARP; PDE	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism
	Ayanin 是从Croton schiedeanus Schlecht 中分离得到的黄酮类物质。它是非选择性的磷酸二酯酶抑制剂，在呼吸道疾病中有研究的价值，如过敏性哮喘等。
T1135	Vitamin D3 维生素D3,Cholecalciferol,Colecalciferol	Endogenous Metabolite	Metabolism
	Vitamin D3 (Cholecalciferol) 是维生素 D 的一种天然存在形式，代谢激活后可以诱导细胞分化和癌细胞增殖。
T4454	Traumatic Acid Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,愈伤酸,Trans-2-Dodecenedioic Acid	Antioxidant	oxidation-reduction
	Traumatic Acid (Dodec-2-Enedioic Acid) 是一种单不饱和二元羧酸，从菜豆中分离得到。它可减少膜磷脂的过氧化，并表现出抗氧化和对胶原生物合成的刺激作用。它可用于许多与胶原蛋白生物合成障碍和氧化应激有关的皮肤疾病的研究。
T21095	4-Hydroxybenzylamine 4-(Aminomethyl)phenol,4-HOBA,4-羟基苄胺	Endogenous Metabolite	Metabolism
	4-Hydroxybenzylamine (4-HOBA) 是内源性代谢产物的一种。
T17056	Tetrahydrobiopterin Sapropterin,BH4,(Rac)-Sapropterin	NOS; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Tetrahydrobiopterin (BH4) 是芳香族氨基酸羟化酶的辅因子, 也是一氧化氮合酶 (NOS) 的必需辅因子，可用于研究如高血压、高胆固醇血症、糖尿病等内皮功能障碍。
T1680	Tolazoline hydrochloride Imidaline hydrochloride,苯甲唑啉盐酸盐,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tolazoline hydrochloride (NSC35110(hydrochloride)) 是一种 α 肾上腺素受体抑制剂。
T4A2458	Resibufogenin 酯蟾毒配基,Bufogenin,Recibufogenin,酯蟾毒配基，蟾力苏	Others	Others
	Resibufogenin (Bufogenin) 是华蟾素的成分之一，表现出抑制氧化应激及肿瘤再生的活性。
TN2285	DL-Tryptophan (±)-Tryptophan,Tryptophan,DL-色氨酸	Serotonin Transporter; Endogenous Metabolite	Metabolism; Neuroscience
	DL-Tryptophan ((±)-Tryptophan) 是内源性代谢产物的一种。
TN7129	Methyl maslinate 马斯里酸甲酯,Maslinic acid methyl ester,Crategolic acid methyl ester	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Methyl maslinate (Maslinic acid methyl ester) 是一种具有强心和抗心律失常特性的 β-肾上腺素受体拮抗剂。Methyl maslinate 可用于高血压研究。
T8301	Amaranth Acid Red 27,酸性红 27	Others	Others
	Amaranth (Acid Red 27) 是一种阴离子染料, 可应用到天然和合成纤维、皮革、纸张及苯酚-甲醛树脂。它是一种暗红色至紫色的偶氮染料，可用作食品染料和化妆品。
T5S0802	Palmatine 巴马汀,Berbericinine,Burasaine	Indoleamine 2,3-Dioxygenase (IDO); AChR; AChE; Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Neuroscience
	Palmatine (Burasaine) 是口服具有活力的、不可逆IDO-1抑制剂。它可以减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，从而改善DSS (Dextran Sulphate Sodium Salt) 诱发的结肠炎。它有用于结肠炎的研究潜力。
T3S2007	MRE-269 3-氧代-12-烯-28-乌苏酸,MRE 269,ACT-333679,MRE269	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	MRE-269 (ACT-333679) 是一种口服的长效前列环素受体激动剂前药，是 Selexipag 的活性代谢物，用于治疗肺动脉高压。
TN7079	coreopsin Butein-4-O-β-D-glucopyranoside,金鸡菊苷	Others	Others
	Coreopsin(Butein-4-O-β-D-glucopyranoside) 是金鸡菊的主要成分之一。在中国传统上被用于治疗高血压和糖尿病以及降低体重和血脂。
T2803	Monocrotaline 野百合碱,Crotaline	TGF-beta/Smad	Stem Cells
	Monocrotaline (Crotaline) 是一种吡咯里西啶生物碱，从猪屎豆植物的种子中提取得到，可诱导啮齿动物产生肺动脉高血压。
T3123	Allicin	ERK; IL Receptor; Others; IκB/IKK; p38 MAPK; TNF; ROS; Caspase; Antifection	Apoptosis; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; Others; Proteases/Proteasome
	Allicin 具有抗氧化、杀菌、抗癌、抗炎活性，对肠上皮细胞具有抑制性免疫调节作用。 Allicin 能显着抑制胰岛素诱导的血管平滑肌细胞的增殖和迁移，这可能与抑制 ERK 信号通路的激活有关。 Allicin 有利于降低高胆固醇血症大鼠的血液胆固醇、甘油三酯水平和收缩压，它可能有益于影响动脉粥样硬化的两个危险因素——高脂血症和高血压。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。
T38649	Lyciumin A	Others	Others
	Lyciumin A, a cyclic octapeptide, possesses inhibitory properties against proteases, renin, and angiotensin-converting enzyme. It holds potential for hypertension research.
TN4654	Niazirin	Others	Others
	The Moringa oleifera extract(including niaziridin and Niazirin) can successfully attenuate the development of pulmonary hypertension via direct vasodilatation and a potential increase in antioxidant activity.
TN4323	Isorauhimbine	Antibiotic	Microbiology/Virology
	Isorauhimbine 是一种从萝芙藤 (R. serpentina) 中提取得到生物碱，具有抗癌、抗炎和抗菌活性，可用于治疗高血压、心律失常和心绞痛等心血管疾病。

天然产物

Liensinine Perchlorate

Cat.No: T3055

Target: Apoptosis, Others

Cat.No: TN1416

Target: IL Receptor, P450, PARP, PDE

Cat.No: T1135

Synonym: 维生素D3,Cholecalciferol,Colecalciferol

Target: Endogenous Metabolite

Cat.No: T4454

Synonym: Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,愈伤酸,Trans-2-Dodecenedioic Acid

Target: Antioxidant

4-Hydroxybenzylamine

Cat.No: T21095

Synonym: 4-(Aminomethyl)phenol,4-HOBA,4-羟基苄胺

Target: Endogenous Metabolite

Tetrahydrobiopterin

Cat.No: T17056

Synonym: Sapropterin,BH4,(Rac)-Sapropterin

Target: NOS, Endogenous Metabolite

Tolazoline hydrochloride

Cat.No: T1680

Synonym: Imidaline hydrochloride,苯甲唑啉盐酸盐,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride)

Target: Adrenergic Receptor

Cat.No: T4A2458

Synonym: 酯蟾毒配基,Bufogenin,Recibufogenin,酯蟾毒配基，蟾力苏

Target: Others

Cat.No: TN2285

Synonym: (±)-Tryptophan,Tryptophan,DL-色氨酸

Target: Serotonin Transporter, Endogenous Metabolite

Methyl maslinate

Cat.No: TN7129

Synonym: 马斯里酸甲酯,Maslinic acid methyl ester,Crategolic acid methyl ester

Target: Adrenergic Receptor

Cat.No: T8301

Synonym: Acid Red 27,酸性红 27

Target: Others

Cat.No: T5S0802

Synonym: 巴马汀,Berbericinine,Burasaine

Target: Indoleamine 2,3-Dioxygenase (IDO), AChR, AChE, Aurora Kinase

Cat.No: T3S2007

Synonym: 3-氧代-12-烯-28-乌苏酸,MRE 269,ACT-333679,MRE269

Target: Prostaglandin Receptor

Cat.No: TN7079

Synonym: Butein-4-O-β-D-glucopyranoside,金鸡菊苷

Target: Others

Cat.No: T2803

Synonym: 野百合碱,Crotaline

Target: TGF-beta/Smad

Cat.No: T3123

Target: ERK, IL Receptor, Others, IκB/IKK, p38 MAPK, TNF, ROS, Caspase, Antifection

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

Cat.No: T38649

Target: Others

Cat.No: TN4654

Target: Others

Cat.No: TN4323

Target: Antibiotic

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01126	COMMD5 Protein, Human, Recombinant (His & Myc) Hypertension-related calcium-regulated gene protein...	Human	Baculovirus Insect Cells
	COMMD5 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus.
TMPH-03269	COMMD5 Protein, Rat, Recombinant (His & Myc) COMM domain-containing protein 5,COMMD5,Hypertension	Rat	E. coli
	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
TMPH-01127	COMMD5 Protein, Human, Recombinant (His) Hypertension-related calcium-regulated gene protein...	Human	E. coli
	COMMD5 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-00545	Dermcidin Protein, Human, Recombinant (hFc) AIDD,PIF,HCAP,dermcidin,DCD-1,DSEP	Human	HEK293 Cells
	Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely diagnoses. Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. And the role of DCD in ischemic heart disease has drawn increasing attention in particular its relationship with insulin secretion and glycemic control, nitric oxide (NO) synthesis ...
TMPY-02575	PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) CIMT1,PPARγ,GLM1,PPARgamma,PPARG1,PPARG2,NR1C3,peroxisome pr...	Human	Baculovirus Insect Cells
	Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proli...
TMPJ-00504	Serpin A8 Protein, Human, Recombinant (His) AGT and SERPINA8,Angiotensinogen,Serpin A8	Human	HEK293 Cells
	Angiotensinogen is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Genetic variations in Angiotensinogen are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the encoding gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
TMPJ-01129	SMAD1 Protein, Human, Recombinant (GST) hSMAD1,Transforming Growth Factor-Beta-Signaling Protein 1,T...	Human	E. coli
	SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated ...
TMPJ-01379	TAC3 Protein, Human, Recombinant (His) Neurokinin-B,Tachykinin-3,UNQ585/PRO1155,NKNB,ZNEUROK1,TAC3,...	Human	E. coli
	Tachykinin 3 (TAC3) is a secreted protein that belongs to the Tachykinin family. Tachykinins are active peptides that excite neurons and evoke behavioral responses; they are potent vasodilators and secretagogues, and contract many smooth muscles in pregnancy. TAC3 is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. It is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension ...
TMPJ-01304	C1QTNF1 Protein, Human, Recombinant (His) C1QTNF1,G Protein-Coupled Receptor-Interacting Protein,CTRP1...	Human	HEK293 Cells
	C1QTNF1 is a secreted protein，contains 1 C1q domain and 1 collagen-like domain. C1qTNF proteins constitute a highly conserved family of Acrp30/Adiponectin paralogs that share a modular organization comprising an N-terminal signal peptide, a short variable region, a collagenous domain and a C-terminal globular domain. C1qTNF proteins are predicted to have trimeric structures that assemble into hexameric and higher order molecular forms. C1QTNF1 is a novel adipokine, providing a significant framew...
TMPJ-01199	BTN2A1 Protein, Human, Recombinant (His) BT2.1,BTN2A1,Butyrophilin subfamily 2 member A1,BTF1	Human	HEK293 Cells
	Butyrophilin 2A1 (BTN2A1) is an approximately widely expressed and variably glycosylated type I transmembrane glycoprotein. Mature human Butyrophilin 2A1 consisits of a 220 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 258 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A1 that lack the first Ig like domain or transmembrane segment as well as isoforms with substitutions and deletion...
TMPY-02574	Chymase 1 Protein, Human, Recombinant (His) MCT1,chymase 1, mast cell,chymase,CYH	Human	Baculovirus Insect Cells
	The STR polymorphism in the CMA1 gene is associated with asthma and that this association is even stronger with atopic asthma. CMA1 and IL-4 in atopic asthma and for IL-4 in atopy in general. The local angiotensin II system (LAS) has numerous functions, including the regulation of growth and differentiation in the gastrointestinal tract. Angiotensin II (AngII) may be generated by angiotensin-I-converting enzyme (ACE) or mast cell chymase (CMA1) and plays an important role in inflammatory process...

重组蛋白

COMMD5 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01126

Species: Human

Expression System: Baculovirus Insect Cells

COMMD5 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03269

Species: Rat

Expression System: E. coli

COMMD5 Protein, Human, Recombinant (His)

Cat.No: TMPH-01127

Species: Human

Expression System: E. coli

Dermcidin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00545

Species: Human

Expression System: HEK293 Cells

PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02575

Species: Human

Expression System: Baculovirus Insect Cells

Serpin A8 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00504

Species: Human

Expression System: HEK293 Cells

SMAD1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01129

Species: Human

Expression System: E. coli

TAC3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01379

Species: Human

Expression System: E. coli

C1QTNF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01304

Species: Human

Expression System: HEK293 Cells

BTN2A1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01199

Species: Human

Expression System: HEK293 Cells

Chymase 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02574

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T10544	Bimatoprost D5 AGN 192024 D5	Others	Others
	Bimatoprost (AGN 192024) D5 is a deuterium-labeled Bimatoprost. Bimatoprost is a topical hypotensive agent frequently used for treating glaucoma and ocular hypertension.
T10229	Acebutolol D7	Others	Others
	Acebutolol D7 is a deuterium-labeled Acebutolol. Acebutolol is a selective antagonist of the β1 adrenergic receptor used in the treatment of angina pectoris, hypertension, and cardiac arrhythmias.
T13195	Trandolapril D5 RU44570 D5	Others	Others
	Trandolapril D5 is a deuterium labeled Trandolapril. Trandolapril is an orally active inhibitor of angiotensin converting enzyme (ACE) for hypertension and congestive heart failure (CHF).
TMID-0043	Sildenafil-d8
	Sildenafil-d8 是 Sildenafil 的氘代化合物。Sildenafil 的 CAS 号为 139755-83-2。Sildenafil 是一种磷酸二酯酶 5 抑制剂，IC50为 5.22 nM。
TMID-0210	Sildenafil-13C-d3
	Sildenafil-13C-d3 是 Sildenafil 的 13C 和氘代化合物。Sildenafil 的 CAS 号为 139755-83-2。Sildenafil 是一种磷酸二酯酶 5 抑制剂，IC50为 5.22 nM。
TMIJ-0131	rac-Valsartan-d9
	rac-Valsartan-d9 是 rac-Valsartan 的氘代化合物。rac-Valsartan 的 CAS 号为 137862-53-4。Valsarta 是一种血管紧张素 II 受体拮抗剂，有用于高血压和心力衰竭的研究潜力。
TMIH-0497	Riociguat-13C-d6
	Riociguat-13C-d6 是 Riociguat 的 13C 和氘代化合物。Riociguat 的 CAS 号为 625115-55-1。Riociguat 是一种鸟苷酸环化酶的刺激剂，可导致血管平滑肌松弛，用于治疗严重的肺动脉高压。
TMIH-0520	Selexipag-d7
	Selexipag-d7 是 Selexipag 的氘代化合物。Selexipag 的 CAS 号为 475086-01-2。Selexipag 是前列环素受体激动剂，可引起肺血管舒张，用于治疗肺动脉高压。
T71065	Quinapril-d5
	Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con...
TMID-0198	Esmolol-d7 HCl
	Esmolol-d7 HCl 是 Esmolol HCl 的氘代化合物。Esmolol HCl 的 CAS 号为 81161-17-3。Esmolol hydrochloride 是一种心脏选择性β受体阻滞剂，用于治疗心律失常和严重高血压。
TMIJ-0253	Benazepril-d5 HCl
	Benazepril-d5 HCl 是 Benazepril HCl 的氘代化合物。Benazepril HCl 的 CAS 号为 86541-74-4。Benazepril hydrochloride 是一种血管紧张素转化酶（ACE）抑制剂，能够作用于高血压。
TMIH-0519	Selexipag Active Metabolite-d7
	Selexipag Active Metabolite-d7 是 Selexipag Active Metabolite 的氘代化合物。Selexipag Active Metabolite 的 CAS 号为 475085-57-5。MRE269 是一种口服的长效前列环素受体激动剂前药，是 Selexipag 的活性代谢物，用于治疗肺动脉高压。
TMID-0063	rac Bendroflumethiazide-d5
	rac Bendroflumethiazide-d5 是 rac Bendroflumethiazide 的氘代化合物。rac Bendroflumethiazide 的 CAS 号为 73-48-3。Bendroflumethiazide 是一种口服具有活性的利尿剂。它是一种抗高血压药。它对动脉高血压疾病具有潜在的研究价值。
T71205	Fosinopril-d7 sodium salt
	Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril reduces fractional shortening and decreases left ventricular size in a porcine model of congesti...
TMIJ-0426	Celiprolol-d9 Hydrochloride
	Celiprolol-d9 Hydrochloride 是 Celiprolol Hydrochloride 的氘代化合物。Celiprolol Hydrochloride 的 CAS 号为 57470-78-7。Celiprolol hydrochloride 是一种选择性肾上腺素受体调节剂，是一种选择性的和具有口服活性的β1肾上腺素受体拮抗剂，具有部分β2激动剂活性，具有降压和抗心绞痛的作用。
TMIH-0087	Amlodipine-d4 Maleate (Racemic)
	Amlodipine-d4 Maleate (Racemic) 是 Amlodipine Maleate (Racemic) 的氘代化合物。Amlodipine Maleate (Racemic) 的 CAS 号为 88150-47-4。Amlodipine maleate是一种具有口服活性的二氢吡啶类钙通道阻滞剂，通过阻滞电压依赖性L型钙通道，从而抑制钙离子内流。Amlodipine maleate可用于研究高血压和癌症。
T70990	ADMA-d6
	NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Da...
T69600	Spermidine-d6
	Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki...

同位素标记化合物

Cat.No: T10544

Synonym: AGN 192024 D5

Target: Others

Cat.No: T10229

Target: Others

Trandolapril D5

Cat.No: T13195

Synonym: RU44570 D5

Target: Others

Cat.No: TMID-0043

Sildenafil-13C-d3

Cat.No: TMID-0210

rac-Valsartan-d9

Cat.No: TMIJ-0131

Riociguat-13C-d6

Cat.No: TMIH-0497

Cat.No: TMIH-0520

Cat.No: T71065

Cat.No: TMID-0198

Benazepril-d5 HCl

Cat.No: TMIJ-0253

Selexipag Active Metabolite-d7

Cat.No: TMIH-0519

rac Bendroflumethiazide-d5

Cat.No: TMID-0063

Fosinopril-d7 sodium salt

Cat.No: T71205

Celiprolol-d9 Hydrochloride

Cat.No: TMIJ-0426

Amlodipine-d4 Maleate (Racemic)

Cat.No: TMIH-0087

Cat.No: T70990

Cat.No: T69600

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