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Search Results for " deficit "

Targets Recommended: Chloride channel

26

抑制剂 & 化合物

3

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T4330	CaCCinh-A01	Chloride channel	Membrane transporter/Ion channel
	CaCCinh-A01 是钙激活氯离子通道和TMEM16A 抑制剂，IC50值分别为 10 和 2.1 μM。
TQ0046	Bavisant JNJ-31001074	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bavisant (JNJ-31001074) 是一种特异性和口服活性的人 H3 受体拮抗剂。 Bavisant 可用于作用机制的研究，包括觉醒和认知以及 ADHD 的治疗。
T2150	Guanfacine hydrochloride 盐酸胍法辛,Tenex,Intuniv,Guanfacine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Guanfacine hydrochloride (Intuniv) 是一种 α2A 肾上腺素受体激动剂，Kd=31 nM，具有抗高血压作用。
T1180	Blonanserin 布南色林,AD-5423	Dopamine Receptor; Sigma receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Blonanserin (AD-5423) 是一种有效的5-HT2A 和多巴胺 D2 受体拮抗剂，Ki 为 0.812 和 0.142 nM，是一种非典型的抗精神病试剂。
T12352L	Oxidopamine hydrobromide 6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide	Mitophagy; Dopamine Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Oxidopamine hydrobromide (6-OHDA hydrobromide) 是一种神经递质多巴胺拮抗剂，可选择性地破坏多巴胺能神经元，是一种广泛使用的神经毒素。
T12352	Oxidopamine hydrochloride 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐	Mitophagy; Dopamine Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) 是一种神经递质多巴胺拮抗剂，可选择性地破坏多巴胺能神经元，是一种广泛使用的神经毒素。
T12054	MK-0249 MK 0249,MK0249	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	MK-0249 是一种具有口服活性、选择性和高效性的 histamine H3 受体拮抗剂（IC50：1.7 nM），可用于研究注意力缺陷和多动障碍。
T7070	Nomifensine maleate Nomifensine (maleate),诺米芬新马来酸盐,(±)-Nomifensine maleat	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Nomifensine maleate (Nomifensine (maleate)) 是一种多巴胺摄取的选择性抑制剂，可用于成人注意力缺陷障碍的研究。
T60201	CX717	GluR	Neuroscience
	CX 717 是 AMPA 受体的正变构调节剂，具有抗抑郁样作用。CX 717 可用于成人注意力缺陷多动障碍（ADHD）的研究。
T12054L	MK-0249 FA MK-0249 FA(862309-06-6 Free base)	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	MK-0249 FA 是一种具有口服活性、选择性和高效性的组胺 H3 反向激动剂，可用于研究成人注意力缺陷、多动症神经分裂和认知障碍。
T27976	Manifaxine BW1555U88,BW-1555U-88,1555U88,1555U-88,GW-320659,GW320659	Others	Others
	Manifaxine, a norepinephrine-dopamine reuptake inhibitor, is used potentially for the treatment of attention deficit.
T24857	TBTC	Others	Others
	TBTC is a selective agonist of retinoid X receptor α that acts by improving behavioral deficit in Alzheimer's disease model mice.
T31604	Edivoxetine LY-2216684,LY 2216684,LY2216684	Others	Others
	Edivoxetine( LY2216684) is a selective norepinephrine reuptake inhibitor being developed as a treatment for attention deficit hyperactivity disorder (ADHD) and antidepressants.
T26529	ABT-418 ABT 418,ABT418,A 81418,A81418,A-81418	Others	Others
	ABT-418, a nicotinic acetylcholine receptor (nAchR) agonist, is used potentially for the treatment of attention deficit disorder.
T10226	Sofiniclin ABT 894	Others	Others
	Sofiniclin (ABT 894) is an agonist of nicotinic acetylcholine receptor (nAChR). It is used for the research for attention-deficit/hyperactivity disorder (ADHD).
T14970	Cipralisant GT-2331	Others	Others
	Cipralisant is a selective histamine H3 receptor antagonist in vivo, and an agonist in vitro (pKi: 9.9 for histamine H3 receptor; Ki: 0.47 nM for rat histamine H3 receptor). It has the potential for the treatment of attention-deficit hyperactivity disorde
T10052	AR-08	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	AR-08 是一种有效的 α2 肾上腺素能受体 (α2-adrenergic receptor) 激动剂，可用于研究多动症与注意力缺陷。
T34752	Samelisant dihydrochloride SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl	Others	Others
	Samelisant dihydrochloride (SUVN-G3031) is a antagonist of histamine H3 receptor with potential for the treatment of cognitive impairment, dementia, attention deficit hyperactivity disorder, epilepsy, sleep disorders, obesity, schizophrenia, eating disorders, and pain.
T61544	Edivoxetine hydrochloride	Others	Others
	Edivoxetine hydrochloride is a highly effective and specialized compound used primarily as a norepinephrine reuptake inhibitor (NERI), indicated for the treatment of depressive disorder and attention-deficit/hyperactivity disorder.
T8443L	MCI-225 hydrochloride hydrate AA-10021,AA10021,MCI225,DDP-225,AA-10025,AA-10026	Others	Others
	MCI-225 is a norepinephrine reuptake/5-HT3/5-HT reuptake inhibitor. MCI-225 could be effective in the treatment of senile dementia of the Alzheimer type, which is accompanied with both deficit in the BF-cortex cholinergic neuron and cerebral glucose hypom
T69595	Ispronicline hemigalactarate	Others	Others
	Ispronicline, also known as AZD3480; TC 1734; TC-0173, and RJR 1734, is a alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. Ispronicline is potentially useful for the treatment of attention-deficit/hyperactivity disorder in adults.
T85224	1,3-Dipalmitoyl-2-Stearoyl Glycerol 16:0/18:0/16:0-TG,TG(16:0/18:0/16:0),1,3-Palmitin-2-Stearin	Others	Others
	1,3-Dipalmitoyl-2-stearoyl glycerol, a triacylglycerol, incorporates palmitic acid at the sn-1 and sn-3 positions and stearic acid at the sn-2 position. This compound's levels diminish in rats experiencing an energy deficit due to restricted food intake, in contrast to those in fed rats.
T60739	Y13g	Others	Others
	Y13g 是白细胞介素 6 (IL-6) 和乙酰胆碱酯酶 (AChE)的有效抑制剂，这两个靶点阿尔茨海默症 (AD) 进展的有关。Y13g 逆转 STZ 诱导的记忆缺陷，并表现出与正常动物相似的组织病理学。
T28653	S-8510 free base SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510	Others	Others
	S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ameliorated memory impairment induced
T60369	Droxidopa hydrochloride	Others	Others
	Droxidopa (L-DOPS) hydrochloride 是一种有效的、具有口服活性的去甲肾上腺素前体。Droxidopa hydrochloride 可增加站立血压，改善直立性低血压症状并提高站立能力。Droxidopa hydrochloride 具有研究神经源性直立性低血压（nOH）和替代性多动症 (注意缺陷多动障碍) 的潜力[3]。
T35560	SAR502250	Others	Others
	SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD)[1][2]. SAR502250 (0.01-1 μM; 36 h) attenuates the Aβ25-35-induced cell death in rat embryonic hippocampal neurons[2]. SAR502250 (1-100 mg/kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mic...

化合物

Cat.No: T4330

Target: Chloride channel

Cat.No: TQ0046

Synonym: JNJ-31001074

Target: Histamine Receptor

Guanfacine hydrochloride

Cat.No: T2150

Synonym: 盐酸胍法辛,Tenex,Intuniv,Guanfacine

Target: Adrenergic Receptor

Cat.No: T1180

Synonym: 布南色林,AD-5423

Target: Dopamine Receptor, Sigma receptor, 5-HT Receptor, Adrenergic Receptor

Oxidopamine hydrobromide

Cat.No: T12352L

Synonym: 6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide

Target: Mitophagy, Dopamine Receptor, Autophagy

Oxidopamine hydrochloride

Cat.No: T12352

Synonym: 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐

Target: Mitophagy, Dopamine Receptor, Autophagy

Cat.No: T12054

Synonym: MK 0249,MK0249

Target: Histamine Receptor

Nomifensine maleate

Cat.No: T7070

Synonym: Nomifensine (maleate),诺米芬新马来酸盐,(±)-Nomifensine maleat

Target: Dopamine Receptor

Cat.No: T60201

Target: GluR

Cat.No: T12054L

Synonym: MK-0249 FA(862309-06-6 Free base)

Target: Histamine Receptor

Cat.No: T27976

Synonym: BW1555U88,BW-1555U-88,1555U88,1555U-88,GW-320659,GW320659

Target: Others

Cat.No: T24857

Target: Others

Cat.No: T31604

Synonym: LY-2216684,LY 2216684,LY2216684

Target: Others

Cat.No: T26529

Synonym: ABT 418,ABT418,A 81418,A81418,A-81418

Target: Others

Cat.No: T10226

Synonym: ABT 894

Target: Others

Cat.No: T14970

Synonym: GT-2331

Target: Others

Cat.No: T10052

Target: Adrenergic Receptor

Samelisant dihydrochloride

Cat.No: T34752

Synonym: SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl

Target: Others

Edivoxetine hydrochloride

Cat.No: T61544

Target: Others

MCI-225 hydrochloride hydrate

Cat.No: T8443L

Synonym: AA-10021,AA10021,MCI225,DDP-225,AA-10025,AA-10026

Target: Others

Ispronicline hemigalactarate

Cat.No: T69595

Target: Others

1,3-Dipalmitoyl-2-Stearoyl Glycerol

Cat.No: T85224

Synonym: 16:0/18:0/16:0-TG,TG(16:0/18:0/16:0),1,3-Palmitin-2-Stearin

Target: Others

Cat.No: T60739

Target: Others

S-8510 free base

Cat.No: T28653

Synonym: SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510

Target: Others

Droxidopa hydrochloride

Cat.No: T60369

Target: Others

Cat.No: T35560

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03852	Dopamine beta-Hydroxylase Protein, Human, Recombinant (His) dopamine β-hydroxylase (dopamine β-monooxygenase),Dopamine β...	Human	HEK293 Cells
	DBH is a 29 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH contains our identical subunits, and its activity requires ascorbate as a cofactor. It functions in in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only transmitter synthesized inside vesicles. DBH has been shown to be associated ...
TMPY-03276	BLBP Protein, Human, Recombinant fatty acid binding protein 7, brain,FABPB,MRG,B-FABP,BLBP,RP...	Human	E. coli
	BLBP, also known as FABP7, is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP7 binds DHA with the highest affinity among all of the FABPs. FABPs may play roles in fatty acid uptake, transport, and metabolism. BLBP is expressed, during development, in radial glia by the activation of notch receptors. It was shown that reelin induces FABP7 expre...
TMPY-04554	JNK1 Protein, Human, Recombinant (GST) PRKM8,JNK,JNK-46,JNK21B1/2,JNK1A2,mitogen-activated protein ...	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. The protein kinases JNK1 has been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. It is critically involved in ...

重组蛋白

Dopamine beta-Hydroxylase Protein, Human, Recombinant (His)

Cat.No: TMPY-03852

Species: Human

Expression System: HEK293 Cells

BLBP Protein, Human, Recombinant

Cat.No: TMPY-03276

Species: Human

Expression System: E. coli

JNK1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04554

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T35591	Guanfacine-13C,15N3 Guanfacine-13C,15N3
	Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin...

同位素标记化合物

Guanfacine-13C,15N3

Cat.No: T35591

Synonym: Guanfacine-13C,15N3

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