Cipralisant

Name: Cipralisant
Brand: TargetMol
SKU: T14970
Price: 816 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T14970Cas号 213027-19-1

别名 GT-2331

Cipralisant is a selective histamine H3 receptor antagonist in vivo, and an agonist in vitro (pKi: 9.9 for histamine H3 receptor; Ki: 0.47 nM for rat histamine H3 receptor). It has the potential for the treatment of attention-deficit hyperactivity disorder.

Cipralisant

还可以

产品编号 T14970 别名 GT-2331Cas号 213027-19-1

规格	价格	库存
25 mg	¥ 13,900	8-10周
50 mg	¥ 18,300	8-10周
100 mg	¥ 23,500	8-10周

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产品介绍

生物活性

产品描述	Cipralisant is a selective histamine H3 receptor antagonist in vivo, and an agonist in vitro (pKi: 9.9 for histamine H3 receptor; Ki: 0.47 nM for rat histamine H3 receptor). It has the potential for the treatment of attention-deficit hyperactivity disorder.
靶点活性	H3 receptor (rat):（ki）0.47 nM, H3 receptor:（pki）9.9
体外活性	Cipralisant acts as a full agonist at the recombinant rat histamine H3 receptor in vitro and potently inhibits forskolin-induced cAMP accumulation (EC50: 0.23 nM). Cipralisant increases the basal [35S]GTPγS binding activities in membranes from HEK cells expressing the rat histamine H3 receptor (EC50: 5.6 nM) [2].
体内活性	Cipralisant (10 mg/kg, p.o.) blocks R-α-methylhistamine (a histamine H3 receptor agonist)-induced water intake in rats [2].
别名	GT-2331