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Search Results for " deacetylase "

Targets Recommended: HDAC

122

抑制剂 & 化合物

5

天然产物

1

化合物库

1

TargetMol 试剂盒

30

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name
L8000	干细胞分化化合物库		1197 compounds
	1197 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合，可用于高通量、高内涵筛选；

化合物库

干细胞分化化合物库

Cat.No: L8000

Compounds: 1197

Cat. No.	Product Name	Form	Specificity Of Inhibition
C0048	Deacetylase Inhibitor Cocktail (100× in 70% DMSO) 去乙酰化酶抑制剂 Cocktail（100× in 70% DMSO）	Solution (100× in 70% DMSO)	Class I/II/III HDAC

TargetMol 试剂盒

去乙酰化酶抑制剂 Cocktail（100× in 70% DMSO）

Cat.No: C0048

Cat. No.	Product Name	Target	Signaling Pathways
T2157	M344 MS 344,Histone Deacetylase Inhibitor III	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	M344 (Histone Deacetylase Inhibitor III) 是一种组蛋白去乙酰化酶抑制剂，IC50为 100 nM。
T3206	NKL 22 Histone Deacetylase Inhibitor IV,PAOA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	NKL 22 (Histone Deacetylase Inhibitor IV) 是一种有效的选择性组蛋白脱乙酰基酶(HDAC) 抑制剂，对 HDAC2/4/5/7/8 具有选择性，抑制HDAC1和HDAC3的IC50值分别为 199 和 69 nM。它可改善亨廷顿氏病转基因小鼠的疾病表型和转录异常。
T3193	Pimelic diphenylamide 106 Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Pimelic diphenylamide 106 (RGFA-8) 是一种缓慢和紧密结合的I 类HDAC 抑制剂，对HDAC1、 2和3的IC50值分别150、760和370 nM。
T39233	SIRT7 inhibitor 97491	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SIRT7 inhibitor 97491 是SIRT7的有效抑制剂，IC50为 325 nM。SIRT7 inhibitor 97491以剂量依赖性的方式降低 SIRT7 去乙酰化酶活性。它通过在 K373/382 处进行乙酰化来提高 p53 的稳定性，从而防止肿瘤进展。它通过 caspase 途径促进凋亡。
T6055	Quisinostat 奎诺司他,JNJ-26481585	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Quisinostat (JNJ-26481585) 是一种高效的，具有口服活性的 pan-HDAC 抑制剂，对 HDAC1、HDAC2、HDAC4、HDAC10、HDAC11 作用的 IC50值范围为 0.11-0.64 nM。它在成神经细胞瘤中能诱导自噬，具有广泛的抗肿瘤活性。
T4328	OSS_128167 SIRT6-IN-1	HBV; Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	OSS_128167 (SIRT6-IN-1) 是一种选择性沉默调节蛋白 6 (SIRT6) 抑制剂，对 SIRT6，SIRT1 和 SIRT2 的 IC50分别为 89 μM，1578 μM 和 751 μM。它具有抗 HBV、抗癌、抗炎和抗病毒活性，可抑制 HBV 的转录和复制。
T6481	Droxinostat NS 41080,4-(4-氯-2-甲基苯氧基)-N-羟基丁酰胺	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Droxinostat (NS 41080) 是HDAC3、HDAC6和HDAC8抑制剂，IC50分别为16.9、2.47和1.46 μM。
T6865	Quisinostat dihydrochloride Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) 是一种有口服活性，高效的 pan-HDAC 抑制剂，具有广泛的抗肿瘤活性。它对 HDAC1、HDAC2、HDAC4、HDAC10和HDAC11 的IC50值分别为 0.11 nM、0.33 nM、0.64 nM、0.46 nM 和 0.37 nM。
T8508	HDAC-IN-3 GSK3117391A	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-3 (GSK3117391A)是组蛋白脱乙酰酶抑制剂，可治疗慢性炎症性疾病。
T7691	NSC 3852	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	NSC 3852 是一种有效的组蛋白脱乙酰酶抑制剂。
T38318L	Acetyl Pentapeptide-1 acetate	Histone Demethylase	Chromatin/Epigenetic
	Acetyl Pentapeptide-1 acetate 是一种组蛋白脱乙酰酶抑制剂。
T8517	Belinostat PX105684,PXD101,贝利司他,PXD-101	HDAC; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Belinostat (PXD101) 是一种异羟肟酸型组蛋白脱乙酰酶抑制剂，具有抗肿瘤活性，在 HeLa 细胞提取物中的IC50为 27 nM。
T2489	Ricolinostat ACY-1215,Rocilinostat	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Ricolinostat (Rocilinostat) 是一种选择性HDAC6抑制剂，IC50为 5 nM。它还抑制HDAC1，HDAC2和HDAC3，IC50分别为 58，48 和 51 nM。
T3983	TMP195 TFMO 2,TMP 195	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	TMP195 (TFMO 2) 是一种选择性 IIa 类组蛋白脱乙酰酶 (HDAC) 抑制剂。对 HDAC4、HDAC5、HDAC7，HDAC9的 Ki 值分别为59、60、26，5 nM。
T4019	Cambinol SIRT1/2 Inhibitor IV,NSC 112546	Apoptosis; Phospholipase; Sirtuin	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Cambinol (SIRT1/2 Inhibitor IV) 是一种SIRT1和SIRT2的抑制剂，IC50值分别为 56 μM 和 59 μM。它是中性鞘磷脂酶的外泌体抑制剂。
T3358	ITSA-1 ITSA1	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	ITSA-1 是一种具有膜渗透性的HDAC 激活剂，抵消曲古抑菌素 A (TSA) 诱导的细胞周期停滞，组蛋白乙酰化和转录水平。
T69753	HDAC6 degrader 9c	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC6 degrader 9c 是一种小分子组蛋白脱乙酰酶 6 （HDAC6）降解剂，可用于研究癌症或其他疾病。
T6678	Splitomicin 1-Naphthalenepropanoic Acid,斯普利特麻一辛	Sirtuin; HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Splitomicin (1-Naphthalenepropanoic Acid) 是 NAD(+) 依赖性组蛋白去乙酰化酶 Sir2p 的特异性抑制剂，可抑制酵母提取物中 HDAC，IC50为 60 μM。
T14947	CHDI-390576	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CHDI-390576 是一种具有中枢神经系统渗透性、选择性和高效性的二苯甲酰异羟肟酸 IIa 类组蛋白脱乙酰酶(HDAC) 抑制剂，抑制 IIa 类 HDAC 4、HDAC 5、HDAC 7、HDAC 9 ，可用于研究癌症。
T37427	(2R/S)-6-PNG 6-Prenylnaringenin,(±)-6-Prenylnaringenin	Calcium Channel; HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	(2R/S)-6-PNG (6-Prenylnaringenin) 是新型天然组蛋白脱乙酰酶抑制剂，具有抗癌抗肿瘤活性，可阻断T型钙通道可减轻小鼠的神经性和内脏疼痛。
T79903	Sirtuin-1 inhibitor 1	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Sirtuin-1 inhibitor 1 是一种针对去乙酰化酶-1（Sirtuin-1）的抑制剂，可用于研究机体的衰老和细胞的死亡。
T16729	Remetinostat SHP-141	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Remetinostat (SHP-141) 是一种基于异羟肟酸的组蛋白脱乙酰酶抑制剂，可用于治疗皮肤 T 细胞淋巴瘤的研究。
T73515	MC2590	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	MC2590 是一种具有有效性和选择性的组蛋白脱乙酰酶 (HDAC) 抑制剂，抑制 HDAC1-3、-6、-8 和 -10 的活性，诱导细胞周期停滞，促进细胞凋亡。
T6111	Selisistat EX-527,司来司他,SEN0014196	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Selisistat (EX-527) 是一种去乙酰化酶 SIRT1 的抑制剂 (IC50=38 nM)，具有有效性和特异性。Selisistat 可以用于神经系统疾病如亨廷顿舞蹈病的研究。
T30579	BRD4097	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BRD4097是HDAC1/2/3/8检测中的阴性对照品,是一种选择性组蛋白去乙酰化酶（HDAC3）抑制剂，可用于保护b 细胞和改善胰岛素抵抗，有助于促进认知功能和增强学习和记忆的形成。
T17028	Tefinostat CHR-2845	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Tefinostat (CHR-2845) 是一种有效的单核细胞/巨噬细胞靶向组蛋白脱乙酰酶 (HDAC) 抑制剂。 Tefinostat 可被胞内酯酶人羧酸酯酶-1 (hCE-1) 裂解成活性酸 CHR-2847。Tefinostat 具有抗肿瘤活性，可用于研究白血病和晚期血液系统恶性肿瘤。
T24131	HDAC3-IN-T247 HDAC3 inhibitor T247,HDAC3 inhibitor-T247,HDAC3 IN T247,T247	Histone Demethylase; Antiviral	Chromatin/Epigenetic; Immunology/Inflammation
	HDAC3-IN-T247 (HDAC3 inhibitor T247) 是一种具有选择性和有效性的组蛋白去乙酰化酶 3（HDAC3）抑制剂，具有抗癌和抗病毒活性。HDAC3-IN-T247 以剂量依赖的方式诱导人结肠癌 HCT116 细胞中 NF-κB 乙酰化。HDAC3-IN-T247 抑制癌细胞增殖。
T21505	Suberoyl bis-hydroxamic acid SBHA,软木肟酸,Suberohydroxamic acid	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Suberoyl bis-hydroxamic acid (SBHA) 是一种竞争性且可透过细胞的HDAC1和HDAC3抑制剂，ID50值分别为 0.25 μM 和 0.30 μM。它使肿瘤细胞易于凋亡并促进线粒体凋亡途径，可研究甲状腺髓样癌。
T1583	Vorinostat MK0683,伏立诺他,suberoylanilide hydroxamic acid,SAHA	Apoptosis; Mitophagy; Virus Protease; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	Vorinostat (SAHA) 是一种泛的组蛋白脱乙酰酶 (HDAC) 抑制剂 (IC50=10 nM)，对 HDAC1/2/3/6/7/11 均有抑制活性。 Vorinostat 具有抗肿瘤活性，可以诱导细胞分化，阻滞细胞周期，诱导细胞凋亡。
T16962	SW-100	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SW-100 是一种选择性组蛋白去乙酰化酶 6 抑制剂，IC50为2.3 nM。它有提高的穿过血脑屏障的能力，相对于其他 HDAC 同工酶，还显示出对 HDAC6 的至少高 1000 倍的选择性。
T2078	Fimepinostat CUDC-907,PI3K/HDAC Inhibitor,CUDC 907	Apoptosis; PI3K; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Fimepinostat (CUDC 907) 是一种 I 型PI3K 及 I 和 II 型HDAC 酶抑制剂，作用于 PI3Kα/PI3Kβ/PI3Kδ 和 HDAC1/HDAC2/HDAC3/HDAC10 ，IC50分别为 19/54/39 nM 和 1.7/5.0/1.8/2.8 nM。
T38521	Patamostat mesylate E 3123 mesylate,E-3123 mesylate,E3123 mesylate	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Patamostat (E-3123) mesylate 是一种组蛋白去乙酰化酶(HDAC)抑制剂。Patamostat mesylate 增加乙酰化的组蛋白和微管蛋白在肿瘤细胞中积累，促使细胞周期终止和细胞凋亡。Patamostat mesylate具有抗肿瘤活性，可用于研究多发性骨髓瘤。
T77334	HDAC-IN-57	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-57 是一种具有口服活性的组蛋白脱乙酰酶 (HDAC) 泛抑制剂，对 HDAC1, HDAC2, HDAC6, HDAC8 具有抑制作用， IC50 值分别为 2.07 nM, 4.71 nM, 2.4 nM 和 107 nM。HDAC-IN-57 对 LSD1具有抑制作用， IC50 值为 1.34 μΜ。HDAC-IN-57 具有抗肿瘤活性，可诱导凋亡 (apoptosis)。
T41275	PF-04753299	Others	Others
	PF-04753299 是一种有效的、选择性的LpxC 抑制剂。PF-04753299 对淋球菌分离株具有杀菌作用，对大肠杆菌、铜绿假单胞菌和肺炎菌株的抑制的MIC90值分别为 2 μg/ml、4 μg/ml 和 16 μg/ml。PF-04753299 用于革兰氏阴性菌感染的研究。
T3661	Citarinostat ACY241,HDAC-IN-2	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Citarinostat (ACY241) 是一种强效、选择性和口服组蛋白脱乙酰酶 (HDAC) 抑制剂，具有抗肿瘤活性，对 HDAC1、HDAC2、HDAC3、HDAC6 和 HDAC8 的 IC50分别为 35、45、46、2.6 和 137 nM。
T64529	MDL-800 MDL 800,MDL800	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SIRT6, responsible for deacetylation of histone H3 Nε-acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac), is a tumor suppressor which has frequently been found to have low expression in various cancers. MDL-800 is a selective SIRT6 activator. It increased the deacetylase activity of SIRT6 by up to 22-fold and led to a global decrease in H3K9ac and H3K56ac levels in human hepatocellular carcinoma (HCC) cells. Also, it inhibited the proliferation of HCC cells via SIRT6-driven cell-cycle arrest and was eff...
T1852	Rac-Belinostat NSC726630,PXD101,PX-105684	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Rac-Belinostat (PX-105684) 是一种具有抗肿瘤活性的新型异羟肟酸型组蛋白脱乙酰酶 (HDAC) 抑制剂。 Belinostat 靶向 HDAC 酶，从而抑制肿瘤细胞增殖、诱导细胞凋亡、促进细胞分化和抑制血管生成。这种药物可以使耐药肿瘤细胞对其他抗肿瘤药物敏感，可能是通过一种涉及胸苷酸合酶下调的机制。
T0005	Aspirin 阿司匹林,Acetylsalicylate,Acetylsalicylic Acid,邻乙酰水杨酸,ASA	Mitophagy; Virus Protease; COX; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Aspirin (Acetylsalicylic Acid) 是一种选择性 COX 抑制剂，具有多种药理活性。它是组蛋白去乙酰化酶抑制剂，可上调细胞周期阻滞蛋白 p21，抑制携带 COX-1 的卵巢 Y 细胞。它还抑制 HUVEC 和新生大鼠心室心肌细胞中 COX-2 的表达，分别减少 PG 的产生和 ERK 和 NF-KB 的下调。
T27083	Crebinostat	Epigenetic Reader Domain; Histone Acetyltransferase; HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Crebinostat 是一种有效的组蛋白去乙酰化酶 (HDAC) 抑制剂，对 HDAC1、HDAC2、HDAC3 和 HDAC6 有抑制作用， IC50 分别为 0.7 nM、1.0 nM、2.0 nM 和 9.3 nM。Crebinostat 可增加在体外神经元的突触蛋白 1 斑点沿树突 (synapsin-1 punctae along dendrites) 的密度。Crebinostat 可调节染色质介导的神经可塑性，增强小鼠的记忆。Crebinostat 可诱导组蛋白 H3 和组蛋白 H4 乙酰化，并增强 cAMP 反应元件结合蛋白 (CREB) 靶基因 Egr1 的表达。
T25629	LAQ 824 LAQ824,LAQ-824	Others	Others
	LAQ 824 is an inhibitor of histone deacetylase.
T27648	J1075 J 1075,J-1075	Others	Others
	J1075 is an histone deacetylase 8 (HDAC8) inhibitor.
T27553	HPB	Others	Others
	HPB is a selective HDAC6 deacetylase inhibitor
T69884	M122	Others	Others
	M122 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.
T27004	CHIC35 CHIC-35,CHIC 35	Others	Others
	CHIC-35 is a selective deacetylase SIRT1 inhibitor.
T84649	CAY10398 MD 85	Others	Others
	CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1).
T25566	KBH-A42 KBH-A-42,KBHA42,KBH-A 42,KBH A 42	Others	Others
	KBH-A42 is an inhibitor of histone deacetylase.
T27644	J1037 J 1037,J-1037	Others	Others
	J1037 is a novel Histone Deacetylase 8 (HDAC8) inhibitor .
T11543	HDAC-IN-5	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.
T27645	J1038 J-1038,J 1038	Others	Others
	J1038 is a novel Histone Deacetylase 8 (HDAC8) Inhibitor .
T24834	ß-Hydroxymethyl chalcone Beta-Hydroxymethyl chalcone,Betahydroxymethyl chalcone,Beta Hydroxymethyl chalcone	Others	Others
	-Hydroxymethyl chalcone is the first selective Histone Deacetylase 2 inhibitor.

化合物

Cat.No: T2157

Synonym: MS 344,Histone Deacetylase Inhibitor III

Target: HDAC

Cat.No: T3206

Synonym: Histone Deacetylase Inhibitor IV,PAOA

Target: HDAC

Pimelic diphenylamide 106

Cat.No: T3193

Synonym: Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8

Target: HDAC

SIRT7 inhibitor 97491

Cat.No: T39233

Target: Sirtuin

Cat.No: T6055

Synonym: 奎诺司他,JNJ-26481585

Target: Apoptosis, HDAC, Autophagy

Cat.No: T4328

Synonym: SIRT6-IN-1

Target: HBV, Sirtuin

Cat.No: T6481

Synonym: NS 41080,4-(4-氯-2-甲基苯氧基)-N-羟基丁酰胺

Target: Apoptosis, HDAC

Quisinostat dihydrochloride

Cat.No: T6865

Synonym: Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl

Target: Apoptosis, HDAC, Autophagy

Cat.No: T8508

Synonym: GSK3117391A

Target: HDAC

Cat.No: T7691

Target: HDAC

Acetyl Pentapeptide-1 acetate

Cat.No: T38318L

Target: Histone Demethylase

Cat.No: T8517

Synonym: PX105684,PXD101,贝利司他,PXD-101

Target: HDAC, Autophagy

Cat.No: T2489

Synonym: ACY-1215,Rocilinostat

Target: Apoptosis, HDAC

Cat.No: T3983

Synonym: TFMO 2,TMP 195

Target: HDAC

Cat.No: T4019

Synonym: SIRT1/2 Inhibitor IV,NSC 112546

Target: Apoptosis, Phospholipase, Sirtuin

Cat.No: T3358

Synonym: ITSA1

Target: HDAC

HDAC6 degrader 9c

Cat.No: T69753

Target: HDAC

Cat.No: T6678

Synonym: 1-Naphthalenepropanoic Acid,斯普利特麻一辛

Target: Sirtuin, HDAC

Cat.No: T14947

Target: HDAC

Cat.No: T37427

Synonym: 6-Prenylnaringenin,(±)-6-Prenylnaringenin

Target: Calcium Channel, HDAC

Sirtuin-1 inhibitor 1

Cat.No: T79903

Target: Sirtuin

Cat.No: T16729

Synonym: SHP-141

Target: HDAC

Cat.No: T73515

Target: Apoptosis, HDAC

Cat.No: T6111

Synonym: EX-527,司来司他,SEN0014196

Target: Sirtuin

Cat.No: T30579

Target: HDAC

Cat.No: T17028

Synonym: CHR-2845

Target: HDAC

Cat.No: T24131

Synonym: HDAC3 inhibitor T247,HDAC3 inhibitor-T247,HDAC3 IN T247,T247

Target: Histone Demethylase, Antiviral

Suberoyl bis-hydroxamic acid

Cat.No: T21505

Synonym: SBHA,软木肟酸,Suberohydroxamic acid

Target: Apoptosis, HDAC

Cat.No: T1583

Synonym: MK0683,伏立诺他,suberoylanilide hydroxamic acid,SAHA

Target: Apoptosis, Mitophagy, Virus Protease, HDAC, Autophagy

Cat.No: T16962

Target: HDAC

Cat.No: T2078

Synonym: CUDC-907,PI3K/HDAC Inhibitor,CUDC 907

Target: Apoptosis, PI3K, HDAC

Patamostat mesylate

Cat.No: T38521

Synonym: E 3123 mesylate,E-3123 mesylate,E3123 mesylate

Target: Apoptosis, HDAC

Cat.No: T77334

Target: Apoptosis, HDAC

Cat.No: T41275

Target: Others

Cat.No: T3661

Synonym: ACY241,HDAC-IN-2

Target: HDAC

Cat.No: T64529

Synonym: MDL 800,MDL800

Target: Sirtuin

Cat.No: T1852

Synonym: NSC726630,PXD101,PX-105684

Target: HDAC

Cat.No: T0005

Synonym: 阿司匹林,Acetylsalicylate,Acetylsalicylic Acid,邻乙酰水杨酸,ASA

Target: Mitophagy, Virus Protease, COX, Autophagy

Cat.No: T27083

Target: Epigenetic Reader Domain, Histone Acetyltransferase, HDAC

Cat.No: T25629

Synonym: LAQ824,LAQ-824

Target: Others

Cat.No: T27648

Synonym: J 1075,J-1075

Target: Others

Cat.No: T27553

Target: Others

Cat.No: T69884

Target: Others

Cat.No: T27004

Synonym: CHIC-35,CHIC 35

Target: Others

Cat.No: T84649

Synonym: MD 85

Target: Others

Cat.No: T25566

Synonym: KBH-A-42,KBHA42,KBH-A 42,KBH A 42

Target: Others

Cat.No: T27644

Synonym: J 1037,J-1037

Target: Others

Cat.No: T11543

Target: HDAC

Cat.No: T27645

Synonym: J-1038,J 1038

Target: Others

ß-Hydroxymethyl chalcone

Cat.No: T24834

Synonym: Beta-Hydroxymethyl chalcone,Betahydroxymethyl chalcone,Beta Hydroxymethyl chalcone

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T14305	Apicidin OSI 2040	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Apicidin (OSI 2040) 是组蛋白去乙酰化酶（HDAC）抑制剂，具有抗寄生虫活性和抗增殖活性。Apicidin 通过减少 APP/PS1 小鼠中的 Abeta 负荷来减轻记忆缺陷，抑制细胞生长增殖，诱导细胞凋亡和自噬，可用于研究白血病。
T6270	Trichostatin A 曲古柳菌素A,曲古抑菌素A,TSA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Trichostatin A (TSA) 属于二烯异羟肟酸类的天然衍生物。Trichostatin A 是一种组蛋白去乙酰化酶抑制剂 (IC50=1.8 nM)，具有可逆性和特异性。Trichostatin A 导致核心组蛋白过度乙酰化，从而调节染色质结构。
T37067	9-hydroxy Stearic Acid	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	9-hydroxy Stearic Acid 是一种羟基脂肪酸，是9-PAHSA 的活性代谢物。9-hydroxy Stearic Acid 是由9-PAHSA 通过肝脏和胰腺的羧基酯脂肪酶形成的。9-hydroxy Stearic Acid (5 μM)抑制HT-29结肠癌细胞裂解物中组蛋白去乙酰化酶1 (HDAC1)的表达。3 .当浓度为100 μM.1时，可抑制HT-29细胞的增殖，并诱导细胞周期阻滞于G0/ g1期。
T70778	Depudecin	Others	Others
	Depudecin is a polyketide obtained from the fungus Alternaria brassicicola and having a highly unusual structure of an 11-carbon chain containing two epoxides and six stereogenic centres. It is an inhibitor of histone deacetylase (HDAC) both in vivo and in vitro and also exhibits anti-angiogenic activity.
T74368	OKI-006	Others	Others
	OKI-006 是一种有效的、具有口服活性的组蛋白脱乙酰酶 (HDAC) 抑制剂。OKI-006 是天然产物HDAC 抑制剂 largazole 的独特同系物。组蛋白去乙酰化酶 (HDAC) 在表观基因组调控中起关键作用，并且组蛋白乙酰化在许多人类癌症中失调。OKI-006 具有研究癌症疾病的潜力。

天然产物

Cat.No: T14305

Synonym: OSI 2040

Target: Apoptosis, HDAC, Autophagy

Cat.No: T6270

Synonym: 曲古柳菌素A,曲古抑菌素A,TSA

Target: HDAC

9-hydroxy Stearic Acid

Cat.No: T37067

Target: HDAC

Cat.No: T70778

Target: Others

Cat.No: T74368

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00051	Chitin deacetylase Protein, Amylomyces rouxii, Recombinant (His) Chitin deacetylase,MrCDA,CDA	Amylomyces rouxii	E. coli
	Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate. Chitin deacetylase Protein, Amylomyces rouxii, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 49.9 kDa and the accession number is P50325.
TMPY-03431	HDAC4 Protein, Human, Recombinant (aa 612-1084) histone deacetylase 4,HA6116,HDAC-4,HD4,BDMR,HDAC-A...	Human	Baculovirus Insect Cells
	HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Th...
TMPY-01333	HDAC8 Protein, Human, Recombinant (GST) histone deacetylase 8,CDA07,MRXS6,RPD3,CDLS5,WTS,HD...	Human	Baculovirus Insect Cells
	HDAC8 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 68 kDa and the accession number is Q9BY41-1.
TMPH-01474	HDAC6 Protein, Human, Recombinant (His) Protein deacetylase HDAC6,Histone deacetylase	Human	E. coli
	HDAC6 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-02317	HDAC8 Protein, Mouse, Recombinant (His) histone deacetylase 8,2610007D20Rik	Mouse	Baculovirus Insect Cells
	HDAC8 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 43.1 kDa and the accession number is Q8VH37-1.
TMPH-00095	HDT2 Protein, Arabidopsis thaliana, Recombinant (His) Histone deacetylase HDT2,Histone deacetylase	Arabidopsis thaliana	P. pastoris (Yeast)
	Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDT2 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 34.3 kDa and the accession number is Q56WH4.
TMPH-01472	HDAC11 Protein, Human, Recombinant (GST) HDAC11,Histone deacetylase 11	Human	E. coli
	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC11 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 66....
TMPH-01476	HDAC9 Protein, Human, Recombinant (His) HDAC9,Histone deacetylase-related protein,MEF2-inte...	Human	E. coli
	HDAC9 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01473	HDAC3 Protein, Human, Recombinant (His & SUMO) Protein deacylase HDAC3,RPD3-2,Protein deacetylase ...	Human	E. coli
	HDAC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 64.8 kDa and the accession number is O15379.
TMPH-01471	HDAC1 Protein, Human, Recombinant (His & SUMO) Histone deacetylase 1,Protein deacetylase ...	Human	E. coli
	HDAC1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 71.1 kDa and the accession number is Q13547.
TMPH-03437	CDA2 Protein, S. cerevisiae, Recombinant (His) CDA2,Chitin deacetylase 2	Saccharomyces cerevisiae	P. pastoris (Yeast)
	Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate. Chitosan is a component of the spore wall. CDA2 Protein, S. cerevisiae, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 34.9 kDa and the accession number is Q06703.
TMPH-00024	LpxC Protein, Acinetobacter baumannii, Recombinant (His) UDP-3-O-acyl-N-acetylglucosamine deacetylase,UDP-3-...	Acinetobacter baumannii	E. coli
	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. LpxC Protein, Acinetobacter baumannii, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.1 kDa and the accession number is B2I1I9.
TMPH-00959	AADAC Protein, Human, Recombinant (His & Myc & SUMO) EC:3.1.1.3,DAC,AADAC,Arylacetamide deacetylase	Human	E. coli
	AADAC Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli.
TMPH-03180	LpxC Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) UDP-3-O-acyl-N-acetylglucosamine deacetylase,lpxC,U...	Pseudomonas aeruginosa	E. coli
	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. LpxC Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 49.4 kDa and the accession number is P47205.
TMPH-00555	LpxC Protein, E. coli, Recombinant (His) lpxC,UDP-3-O-acyl-N-acetylglucosamine deacetylase,U...	E. coli	E. coli
	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
TMPH-03179	LpxC Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO) UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deace...	Pseudomonas aeruginosa	E. coli
	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. LpxC Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 53.4 kDa and the accession number is A6VB79.
TMPH-02378	LpxC Protein, Klebsiella pneumoniae, Recombinant (His & Myc) UDP-3-O-acyl-N-acetylglucosamine deacetylase,UDP-3-...	Klebsiella pneumoniae	E. coli
	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
TMPH-03569	IcaB Protein, S. aureus, Recombinant (His & Myc) Intercellular adhesion protein B,Poly-beta-1,6-N-acetyl-D-gl...	Staphylococcus aureus	E. coli
	Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions. IcaB Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular ...
TMPJ-00459	Esterase D Protein, Human, Recombinant (His) FGH,Methylumbelliferyl-Acetate Deacetylase,ESD,S-Fo...	Human	E. coli
	Human Esterase D is a cytoplasmic serine hydrolase that belongs to the esterase D family. Esterase D is involved in the detoxification of formaldehyde. Esterase D plays a part in a variety of substrates, including O-acetylated sialic acids, which may involves in the recycling of sialic acids. Esterase D is used as a genetic marker for retinoblastoma and Wilson’s disease.
TMPH-00712	PGAB Protein, E. coli, Recombinant (His & Myc) Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase,...	E. coli	E. coli
	Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide. N-deacetylation promotes PGA export through the PgaA porin. PGAB Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 82.6 kDa and the accession number is P75906.
TMPH-01007	NDST1 Protein, Human, Recombinant (His & SUMO) Glucosaminyl N-deacetylase/N-sulfotransferase 1,[He...	Human	E. coli
	NDST1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 73.5 kDa and the accession number is P52848.
TMPH-02798	SIRT3 Protein, Mouse, Recombinant (His & Myc) Regulatory protein SIR2 homolog 3,Sirt3,NAD-dependent protei...	Mouse	E. coli
	SIRT3 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 36.3 kDa and the accession number is Q8R104.
TMPH-02709	SAP130 Protein, Mouse, Recombinant (His) Sap130,130 kDa Sin3-associated polypeptide,Sin3-associated p...	Mouse	E. coli
	Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. SAP130 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.8 kDa and the accession number is Q8BIH0.
TMPH-01804	OARD1 Protein, Human, Recombinant (His & Myc) OARD1,ADP-ribose glycohydrolase OARD1,Terminal ADP-ribose pr...	Human	E. coli
	OARD1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.3 kDa and the accession number is Q9Y530.
TMPH-01742	SIRT6 Protein, Human, Recombinant (GST) Protein mono-ADP-ribosyltransferase sirtuin-6,NAD-dependent ...	Human	E. coli
	SIRT6 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 66.0 kDa and the accession number is Q8N6T7.
TMPH-00907	MACROD1 Protein, Human, Recombinant (His) MACROD1,Protein LRP16,O-acetyl-ADP-ribose deacetylase	Human	E. coli
	MACROD1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.5 kDa and the accession number is Q9BQ69.
TMPH-00908	MACROD1 Protein, Human, Recombinant (His & Myc) ADP-ribose glycohydrolase MACROD1,MACROD1,[Protein ADP-ribos...	Human	Baculovirus Insect Cells
	MACROD1 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus.
TMPJ-01121	MORF4L2 Protein, Human, Recombinant (His) MORF4L2,Transcription Factor-Like Protein MRGX,Protein MSL3-...	Human	E. coli
	Mortality Factor 4-Like Protein 2 (MORF4L2) is a member of the mortality factor (MORF) family. MORF4L2 localizes in the nucleus, possessing a protein kinase C phosphorylation site and a tyrosine phosphorylation site. MORF4L2 interacts with the Rb tumor suppressor and it has histone deacetylase activity which can either repress or promote the activity of the B-Myb promoter depending on the tissue. In addition, MORF4L2 is involved in cell growth, regulation, and senescence.
TMPY-03283	HBP1 Protein, Human, Recombinant (GST) HMG-box transcription factor 1	Human	E. coli
	HBP1 is a sequence-specific DNA-binding transcription factor. It is involved in many biological processes. It was reported that HBP1 binds to p16(INK4A) promoter and activates p16(INK4A) expression. We found that trichostatin A (TSA), an inhibitor of HDAC (histone deacetylase), induces p16(INK4A) expression in an HBP1-dependent manner. HBP1 activates or represses the expression of some specific genes during cell growth and differentiation. HBP1 was acetylated by p3/CBP in two regions: repression...
TMPY-01869	SIRT1 Protein, Human, Recombinant (His) SIR2L1,sirtuin 1	Human	E. coli
	SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent protein deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. It deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. SIRT1 also deacetylates TAF1B and there...

重组蛋白

Chitin deacetylase Protein, Amylomyces rouxii, Recombinant (His)

Cat.No: TMPH-00051

Species: Amylomyces rouxii

Expression System: E. coli

HDAC4 Protein, Human, Recombinant (aa 612-1084)

Cat.No: TMPY-03431

Species: Human

Expression System: Baculovirus Insect Cells

HDAC8 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01333

Species: Human

Expression System: Baculovirus Insect Cells

HDAC6 Protein, Human, Recombinant (His)

Cat.No: TMPH-01474

Species: Human

Expression System: E. coli

HDAC8 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02317

Species: Mouse

Expression System: Baculovirus Insect Cells

HDT2 Protein, Arabidopsis thaliana, Recombinant (His)

Cat.No: TMPH-00095

Species: Arabidopsis thaliana

Expression System: P. pastoris (Yeast)

HDAC11 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01472

Species: Human

Expression System: E. coli

HDAC9 Protein, Human, Recombinant (His)

Cat.No: TMPH-01476

Species: Human

Expression System: E. coli

HDAC3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01473

Species: Human

Expression System: E. coli

HDAC1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01471

Species: Human

Expression System: E. coli

CDA2 Protein, S. cerevisiae, Recombinant (His)

Cat.No: TMPH-03437

Species: Saccharomyces cerevisiae

Expression System: P. pastoris (Yeast)

LpxC Protein, Acinetobacter baumannii, Recombinant (His)

Cat.No: TMPH-00024

Species: Acinetobacter baumannii

Expression System: E. coli

AADAC Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00959

Species: Human

Expression System: E. coli

LpxC Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO)

Cat.No: TMPH-03180

Species: Pseudomonas aeruginosa

Expression System: E. coli

LpxC Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00555

Species: E. coli

Expression System: E. coli

LpxC Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03179

Species: Pseudomonas aeruginosa

Expression System: E. coli

LpxC Protein, Klebsiella pneumoniae, Recombinant (His & Myc)

Cat.No: TMPH-02378

Species: Klebsiella pneumoniae

Expression System: E. coli

IcaB Protein, S. aureus, Recombinant (His & Myc)

Cat.No: TMPH-03569

Species: Staphylococcus aureus

Expression System: E. coli

Esterase D Protein, Human, Recombinant (His)

Cat.No: TMPJ-00459

Species: Human

Expression System: E. coli

PGAB Protein, E. coli, Recombinant (His & Myc)

Cat.No: TMPH-00712

Species: E. coli

Expression System: E. coli

NDST1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01007

Species: Human

Expression System: E. coli

SIRT3 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02798

Species: Mouse

Expression System: E. coli

SAP130 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02709

Species: Mouse

Expression System: E. coli

OARD1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01804

Species: Human

Expression System: E. coli

SIRT6 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01742

Species: Human

Expression System: E. coli

MACROD1 Protein, Human, Recombinant (His)

Cat.No: TMPH-00907

Species: Human

Expression System: E. coli

MACROD1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-00908

Species: Human

Expression System: Baculovirus Insect Cells

MORF4L2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01121

Species: Human

Expression System: E. coli

HBP1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-03283

Species: Human

Expression System: E. coli

SIRT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01869

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0163	Valproic Acid-d4
	Valproic Acid-d4 是 Valproic Acid 的氘代化合物。Valproic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂，可抑制HDAC1的活性，同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。
TMIJ-0431	2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid
	2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid 是 2-pentanoic Acid 的氘代化合物。2-pentanoic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂，可抑制HDAC1的活性，同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。
TMID-0120	Valproic Acid-d15
	Valproic Acid-d15 是 Valproic Acid 的氘代化合物。Valproic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂，可抑制HDAC1的活性，同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。

同位素标记化合物

Valproic Acid-d4

Cat.No: TMIJ-0163

2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid

Cat.No: TMIJ-0431

Valproic Acid-d15

Cat.No: TMID-0120

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