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Search Results for " h460 "

45

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1889	CP-640186 CP 640186	Acetyl-CoA Carboxylase	Metabolism
	CP-640186 是一种有效的乙酰辅酶 A 羧化酶 (ACC)抑制剂，抑制大鼠肝脏 ACC1 和大鼠骨骼肌 ACC2 的 IC50分别为 53 nM 和 61 nM。
T8756	KRAS inhibitor-9 DUN09716	Apoptosis; Ras	Apoptosis; GPCR/G Protein; MAPK
	KRAS inhibitor-9 (DUN09716) 是一种 KRAS 抑制剂，阻止 GTP-KRAS 的形成和 KRAS 下游激活。它以中等的结合亲和力与 KRAS G12D、KRAS G12C 和 KRAS Q61H 蛋白结合，选择性抑制具有 KRAS 突变的 NSC-LC 细胞的增殖。它可导致 G2/M 细胞周期停滞并诱导凋亡。
T6967	RHPS4 RHPS 4 methosulfate,NSC714187	Apoptosis; Telomerase	Apoptosis; DNA Damage/DNA Repair
	RHPS4 (RHPS 4 methosulfate) 是 DNA 损伤诱导剂，是一种有效的亚微摩尔端粒酶抑制剂，IC50为0.33 μM。
TQ0059	Ilorasertib ABT-348	VEGFR; FLT; c-RET; PDGFR; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	Ilorasertib (ABT-348) 是一种 ATP 竞争性多靶点激酶抑制剂，可抑制 Aurora A、Aurora B 和Aurora C，IC50值为120 nM、7 nM 和1 nM。它还抑制 RET 酪氨酸激酶、PDGFRβ 和 Flt1，IC50为7 nM、3 nM 和 32 nM。
T6019	Volasertib BI 6727,伏拉塞替	Apoptosis; PLK	Apoptosis; Cell Cycle/Checkpoint
	Volasertib (BI 6727) 是一种具有口服活性的高效ATP 竞争性Polo 样激酶 1 抑制剂。它抑制 PLK2 和 PLK3，IC50分别为 5 和 56 nM。它是二氢蝶呤酮衍生物，有抗肿瘤活性，可诱导有丝分裂停滞和细胞凋亡。
T5337	IACS-010759 IACS-10759,IACS 10759,IACS10759	Apoptosis; Others; Mitochondrial Metabolism	Apoptosis; Metabolism; Others
	IACS-010759 是一种口服有效的线粒体氧化磷酸化复合物 I 抑制剂。它在依赖 OXPHOS 的脑癌和急性髓性白血病模型中抑制增殖并诱导细胞凋亡，有研究复发/难治性 AML 和实体瘤潜力。
T60012	HS-243	IRAK; MAPK; CDK	Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; NF-κB
	HS-243 是 IRAK-4 和 IRAK-1 的抑制剂，IC50 分别为 20 和 24 nM。 HS-243 显示出抗炎和抗癌活性。
T3622	CP-640186 hydrochloride CP 640186 HCl,盐酸CP-640186	Acetyl-CoA Carboxylase	Metabolism
	CP-640186 hydrochloride (CP 640186 HCl) 是膜渗透性的乙酰辅酶A 羧化酶（ACC）抑制剂，抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的IC50为53 nM 和61 nM。
T20168	Aurothiomalate sodium 金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Aurothiomalate sodium (Miochrysin) 是一种选择性的致癌 PKCι信号传导抑制剂，可抑制肿瘤细胞增殖。它是一种硫氧还蛋白还原酶 (TrxR) 抑制剂，也是一种抗风湿剂。
T5858	Sertindole Lu 23-174,舍吲哚	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Sertindole (Lu 23-174) 是一种非典型抗精神病药，可与多巴胺 D2 受体和血清素受体亚型 5-HT1D、5-HT2A 和 5-HT2C 结合，Kd 值分别为 2.7、20、0.14 和 6 nM。
T9003	CVT-11127 N-[2-[6-[[(3,4-二氯苯基)甲基]氨基]-2-(4-甲氧基苯基)-3-氧代-3,4-二氢吡啶并[2,3-B]吡嗪-4-基]乙基]乙酰胺	Dehydrogenase	Metabolism
	CVT-11127 是 SCD 抑制剂。它将细胞周期阻滞在 G1/S 期，诱导细胞凋亡。它可用于肺癌的研究。
T69860	PSB-15160	Others	Others
	PSB-15160是治疗雌激素依赖性肿瘤的化合物，对MCF7(乳腺)、NCI-H460(肺)和SF-268 (NCS)细胞的生长具有抑制作用。
T77762	ROS-generating agent 1	Apoptosis; Ferroptosis; ROS Kinase	Apoptosis; Tyrosine Kinase/Adaptors
	ROS-generating agent 1 具有抗癌活性,通过共价修饰 TrxR 的 Sec-498 残基以生成 ROS。ROS-generating agent 1 降低细胞内 TrxR 蛋白水平，促进 NCI-H460 细胞中 ROS 依赖的性细胞凋亡 (apoptosis) 和铁死亡 (ferroptosis)。
T62867	Microtubule inhibitor 3	Others	Others
	化合物17o（IC50: 14.0 nM，NCI-H460）和17p（IC50: 2.9 nM，NCI-H460）与呋喃基团在纳摩尔水平上对各种人类癌细胞系显示出有效的细胞毒性作用。
T68061	Elinafide	Others	Others
	Elinafide 是一种双萘酰亚胺细胞毒性剂，是 DNA 靶向抗癌剂，在体内体外实验中显示出抗肿瘤活性。
T74340	DNA crosslinker 4 dihydrochloride	Others	Others
	DNA crosslinker 4 (dihydrochloride) 作为高效的DNA小沟结合剂，对NCI-H460、A2780和MCF-7癌细胞表现出显著抑制活性，适用于抗癌研究。
T83892	33-BCRP Inhibitor 33-Breast Cancer Resistance Protein Inhibitor	Others	Others
	33-BCRP抑制剂是一种乳腺癌耐药蛋白(BCRP)的抑制剂。它使得对米托蒽醌耐药的H460/MX20肺癌细胞对米托蒽醌诱导的细胞死亡更加敏感，无论是单独使用还是与UV辐射联合使用。33-BCRP抑制剂还能够增强表达P-糖蛋白(P-gp，亦称为多药耐药蛋白MDR)的KB-C2表皮癌细胞对秋水仙碱诱导的细胞死亡的敏感性。当使用5 µM浓度时，它能增加米托蒽醌在H460/MX20细胞中的细胞内积累。
T38382	8Br-HA	Others	Others
	8Br-HA is an inhibitor of fragile histidine triad diadenosine triphosphatase (FHIT; IC50= 0.12 μM).1It inhibits the growth of HCC827 and H460 lung cancer cells (GI50s = 0.87 and 5.9 μM, respectively). 1.Kawaguchi, M., Sekimoto, E., Ohta, Y., et al.Synthesis of fluorescent probes targeting tumor-suppressor protein FHIT and Identification of apoptosis-inducing FHIT inhibitorsJ. Med. Chem.64(13)9567-9576(2021)
T74338	DNA crosslinker 2 dihydrochloride	Others	Others
	DNA crosslinker 2 (dihydrochloride)为一种高效DNA小沟结合剂，其结合亲和力(ΔTm)达1.2°C。该化合物对NCI-H460、A2780及MCF-7癌细胞展示出抑制活性，适用于抗癌研究。
T61996	Antiproliferative agent-6	Others	Others
	Antiproliferative agent-6 (compound 8a) 是有效的抗肿瘤化合物。Antiproliferative agent-6 具有抗增殖活性，抑制癌细胞系 HCT116、MCF-7、H460 和非肿瘤非整倍体永生角质细胞 HaCaT 的 GI50分别为 0.5 μM、2 μM、0.7 μM 和 3.5 μM。
T62639	Microtubule inhibitor 7	Others	Others
	化合物17o（IC50= 14.0 nM，NCI-H460）和 17p（IC50= 2.9 nM，NCI-H460）与呋喃基团对各种人类癌症细胞系显示出有效的纳摩尔水平的细胞毒活性。
T63668	Anticancer agent 16	Others	Others
	Anticancer agent 16 对 HCT-116 细胞系 (IC50: 8.55 μM)、NCI-H460 细胞系 (IC50: 5.41 μM) 和 SKOV3 细胞系 (IC50: 6.4 μM)表现出良好的细胞毒效果。
T37541	Amycolatopsin C	Others	Others
	Amycolatopsin C is a polyketide macrolide originally isolated fromAmycolatopsisthat has antimycobacterial and anticancer activities.1It is active againstM. bovisandM. tuberculosis(IC50s = 2.7 and 5.7 μM, respectively) but notB. subtilis,S. aureus,E. coli, orP. aeruginosa(IC50s = >30 μM for all). Amycolatopsin C is cytotoxic to SW620 colorectal and NCI H460 lung cancer cells (IC50s = 10 and 5.9 μM, respectively). 1.Khalil, Z.G., Salim, A.A., Vuong, D., et al.Amycolatopsins A-C: Antimycobacterial ...
T40212	ATR-IN-4	Others	Others
	ATR-IN-4, a potent inhibitor of ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase), restricts the growth of DU145 prostate cancer cells and NCI-H460 lung cancer cells, with IC 50 values of 130.9 nM and 41.33 nM, respectively.
T61765	Microtubule inhibitor 5	Others	Others
	Microtubule inhibitor 5 (compound 17f) is a highly potent cytotoxic agent that inhibits microtubule function. It exhibits a substantial cytotoxic effect on NCI-H460 cells, with an IC50 value of 154.5 nM. Moreover, this compound demonstrates excellent cell permeability [1].
T37540	Amycolatopsin B	Others	Others
	Amycolatopsin B is a bacterial metabolite originally isolated fromAmycolatopsisthat has anticancer activity.1It is cytotoxic to NCI H460 lung and SW620 colon cancer cells (IC50s = 0.28 and 0.14 μM, respectively). 1.Khalil, Z.G., Salim, A.A., Vuong, D., et al.Amycolatopsins A-C: Antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494J. Antibiot. (Tokyo)70(12)1097-1103(2017)
T73243	NSD3-IN-2	Others	Others
	NSD3-IN-2 是一种有效的 NSD3抑制剂 (IC50=17.97 μM)。NSD3-IN-2 具有抗癌活性，可抑制非小细胞肺癌细胞系 H460、H1299 和 H1650 的生长和增殖。
T83011	Antitumor agent-105	Others	Others
	Antitumor agent-105（Compound 37）是一种对A549、H1299、H460、HCT116、MDA-MB-231细胞线显示出抗肿瘤活性的化合物，其IC50值分别为6.7、8.3、4.3、4.4、6.7μM。
T73244	NSD3-IN-3	Others	Others
	NSD3-IN-3，一种高效的NSD3抑制剂 (IC50=1.86 μM)，对非小细胞肺癌细胞系H460的生长和增殖具有显著的抑制作用，表现出抗癌活性。
T35438	(5E)-7-Oxozeaenol	Others	Others
	(5E)-7-Oxozeaenol is a resorcylic acid lactone that has been found in the fungus MSX 63935 and has enzyme inhibitory and anticancer activities.1,2 It inhibits TGF-β-activated kinase 1 (TAK-1; IC50 = 1.3 μM).1 (5E)-7-Oxozeaenol inhibits proliferation of MCF-7, H460, SF-268, HT-29, and MDA-MB-435 human cancer cells with IC50 values of 4.9, 1.2, 5.6, 4.4, and 5.5 μM, respectively.2 \|1. Fakhouri, L., El-Elimat, T., Hurst, D.P., et al. Isolation, semisynthesis, covalent docking and transforming growt...
T37539	Amycolatopsin A	Others	Others
	Amycolatopsin A is a macrolide polyketide originally isolated fromAmycolatopsisthat has antimycobacterial and anticancer activities.1It is active againstM. bovisandM. tuberculosis(IC50s = 0.4 and 4.4 μM, respectively) but notB. subtilis,S. aureus,E. coli, orP. aeruginosa(IC50s = >30 μM for all). Amycolatopsin A is cytotoxic to SW620 colorectal and NCI H460 lung cancer cells (IC50s = 0.08 and 1.2 μM, respectively). 1.Khalil, Z.G., Salim, A.A., Vuong, D., et al.Amycolatopsins A-C: Antimycobacteria...
T37758	Unguinol	Others	Others
	Unguinol is a depsidone originally isolated from A. unguis. It is an inhibitor of pyruvate phosphate dikinase (PPDK; IC50 = 42.3 μM). It inhibits the growth of plants utilizing C4, but not C3, carbon fixation. Unguinol also inhibits the growth of the bacteria S. aureus and V. harveyi (GI50s = 8.7 and 69.5 μM, respectively) and H460, MCF-7, and SF-268 cancer cells (GI50s = 28.2, 50.8, and 44.3 μM, respectively).
T83865	HP661	Others	Others
	HP661是一种针对线粒体复合物I（也称为NADH脱氢酶）的抑制剂，对复合物I具有选择性，以1 µM的浓度抑制其77.6%，而对复合物III抑制率为28.1%，对复合物II和IV则无抑制作用。HP661特异性降低具有高水平氧化磷酸化作用的人类肺癌细胞H460、NCI H441及对trametinib耐药的A549细胞的生存能力（IC50分别为10.6、29.7和15.1 nM），相较于氧化磷酸化水平低的NCI H358人类肺癌细胞（IC50 >10,000 nM）以及非癌性人类胰腺正常上皮细胞（HPNE）和MRC-5人类胎肺成纤维细胞（两者的IC50均>10,000 nM）。当以每天两次，每次30 mg/kg的剂量给药时，HP661在H460小鼠异种移植模型中减少肿瘤体积，并对trametinib引导的肿瘤生长减少产生加成效应。
T36449	(S)-α-Methylbenzyl Ricinoleamide	Others	Others
	(S)-α-Methylbenzyl ricinoleamide is a fatty acid amide derived from ricinoleic acid and methyl benzylamine. It demonstrates potent growth inhibition of glioma (U251), breast (MCF-7), ovarian (NCI-ADR/RES and OVCAR-3), kidney (786-0), non-small cell lung (NCI-H460), and prostate (PC-3) cancer cells with a mean GI50 value of 6.9 μM.
T62448	Microtubule inhibitor 6	Others	Others
	Microtubule inhibitor 6 (compound 17o) 是一种有效的微管抑制剂。Microtubule inhibitor 6 对 NCI-H460 细胞、BxPC-3 细胞、HT-29 细胞表现出细胞毒性，他们的 IC50 值分别为 14.0、6.6、7.0 nM。Microtubule inhibitor 6 能够有效抑制微管聚合。
T63590	c-Met-IN-10	Others	Others
	c-Met-IN-10 是高效的 c-Met 激酶抑制剂 (IC50: 16 nM)。c-Met-IN-10 能够抑制癌细胞 A549、H460 和 HT-29 的活性，通过抑制 HT-29 细胞集落形成，进而诱导 HT-29 和 A549 细胞凋亡 apoptosis，抑制 A549 细胞移动。c-Met-IN-10 能够用于抗癌研究。
T79451	WES-1	Carbonic Anhydrase	Metabolism
	WES-1（Compound 8g）是一种针对碳酸酐酶IX的抑制剂，其抑制常数（Ki）为55.9 μM。该化合物对包括白血病细胞系（K-562、MOLT-4）、非小细胞肺癌（NCI-H460）、结肠癌（HCT 116、HCT-15）以及黑色素瘤（LOX IMVI）在内的多种癌细胞表现出抗增殖效果。
T78780	Anticancer agent 139	Others	Others
	Anticanceragent 139（Compound 6h）展现了针对多种癌细胞株的抗癌效能。该化合物能够与Tubulin的Lys352残基发生π-阳离子相互作用。在对SNB-19、OVCAR-8和NCI-H460细胞株的测试中，Anticanceragent 139展现出较高的生长抑制率（PGI），数值分别为86.61、85.26和75.99。同时，该化合物对于HOP-62、SNB-75、ACHN、NCI/ADR-RES、786-O、A549/ATCC、HCT-116以及MDA-MB-231细胞株亦表现出中等的生长抑制作用，其PGI值分别为67.55、65.46、59.09、59.02、57.88、56.88、56.53和56.4、51.88。
T35675	SW203668 (trifluoroacetate salt)	Others	Others
	SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production...
T84413	Cdk4 Inhibitor Cyclin-dependent kinase 4 Inhibitor	Others	Others
	PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell gr...
T70856	3-Oxobetulin Acetate	Others	Others
	3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 µg/ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 µg/ml for both). 3-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblasto...
T37006	Previridicatumtoxin	Others	Others
	Previridicatumtoxin is a fungal metabolite that has been found inP. aethiopicumand has diverse biological activities.1,2It is an intermediate in the biosynthesis of the mycotoxin viridicatumtoxin . Previridicatumtoxin is active against methicillin-resistantS. aureus(MRSA) and vancomycin-resistantE. faecalis(IC50s = 4.4 and 4.8 μM, respectively), as well asC. albicansandS. cerevisiae(MIC = 32 μg/ml for both).2,1It is cytotoxic to NCI H460, KB-3-1, and SW620 cancer cells (IC50s = 5.3, 4.1, and 6 μ...
T62642	Microtubule inhibitor 4	Others	Others
	Microtubule inhibitor 4 (compound 2) 是一种有效的 microtubule 抑制剂。Microtubule inhibitor 4 对 NCI-H460 (IC50s: 4.0 nM)、BxPC-3 (IC50s: 3.2 nM)、HT-29 (IC50s: 2.1 nM) 细胞具有细胞毒性。Microtubule inhibitor 4 能够抑制微管蛋白聚合。
T85108	17(R)-Resolvin D3 Aspirin-triggered Resolvin D3,AT-RvD3,17(R)-RvD3,17-epi-Resolvin D3	Others	Others
	17(R)-Resolvin D3 (17(R)-RvD3) is an aspirin-triggered epimer of resolvin D3, produced from docosahexaenoic acid (DHA) through the action of COX-2 in the presence of aspirin, via a 17(R)-hydroperoxy DHA (17(R)-HDHA) intermediary. Identified in mouse inflammatory exudates, 17(R)-RvD3 notably inhibits the transmigration of isolated human polymorphonuclear cells (PMNs) and fosters the efferocytosis of apoptotic PMNs by macrophages. Furthermore, in a mouse model of zymosan-induced peritonitis, 17(R)...
T13226	Tubulin inhibitor 8	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 8是管蛋白和多种癌症细胞系的抑制剂，对管蛋白聚合和K562细胞生长具有抑制作用，IC50分别为0.73μM 和14nM。

化合物

Cat.No: T1889

Synonym: CP 640186

Target: Acetyl-CoA Carboxylase

KRAS inhibitor-9

Cat.No: T8756

Synonym: DUN09716

Target: Apoptosis, Ras

Cat.No: T6967

Synonym: RHPS 4 methosulfate,NSC714187

Target: Apoptosis, Telomerase

Cat.No: TQ0059

Synonym: ABT-348

Target: VEGFR, FLT, c-RET, PDGFR, Aurora Kinase

Cat.No: T6019

Synonym: BI 6727,伏拉塞替

Target: Apoptosis, PLK

Cat.No: T5337

Synonym: IACS-10759,IACS 10759,IACS10759

Target: Apoptosis, Others, Mitochondrial Metabolism

Cat.No: T60012

Target: IRAK, MAPK, CDK

CP-640186 hydrochloride

Cat.No: T3622

Synonym: CP 640186 HCl,盐酸CP-640186

Target: Acetyl-CoA Carboxylase

Aurothiomalate sodium

Cat.No: T20168

Synonym: 金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate

Target: Others, PKC

Cat.No: T5858

Synonym: Lu 23-174,舍吲哚

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Autophagy

Cat.No: T9003

Synonym: N-[2-[6-[[(3,4-二氯苯基)甲基]氨基]-2-(4-甲氧基苯基)-3-氧代-3,4-二氢吡啶并[2,3-B]吡嗪-4-基]乙基]乙酰胺

Target: Dehydrogenase

Cat.No: T69860

Target: Others

ROS-generating agent 1

Cat.No: T77762

Target: Apoptosis, Ferroptosis, ROS Kinase

Microtubule inhibitor 3

Cat.No: T62867

Target: Others

Cat.No: T68061

Target: Others

DNA crosslinker 4 dihydrochloride

Cat.No: T74340

Target: Others

33-BCRP Inhibitor

Cat.No: T83892

Synonym: 33-Breast Cancer Resistance Protein Inhibitor

Target: Others

Cat.No: T38382

Target: Others

DNA crosslinker 2 dihydrochloride

Cat.No: T74338

Target: Others

Antiproliferative agent-6

Cat.No: T61996

Target: Others

Microtubule inhibitor 7

Cat.No: T62639

Target: Others

Anticancer agent 16

Cat.No: T63668

Target: Others

Amycolatopsin C

Cat.No: T37541

Target: Others

Cat.No: T40212

Target: Others

Microtubule inhibitor 5

Cat.No: T61765

Target: Others

Amycolatopsin B

Cat.No: T37540

Target: Others

Cat.No: T73243

Target: Others

Antitumor agent-105

Cat.No: T83011

Target: Others

Cat.No: T73244

Target: Others

(5E)-7-Oxozeaenol

Cat.No: T35438

Target: Others

Amycolatopsin A

Cat.No: T37539

Target: Others

Cat.No: T37758

Target: Others

Cat.No: T83865

Target: Others

(S)-α-Methylbenzyl Ricinoleamide

Cat.No: T36449

Target: Others

Microtubule inhibitor 6

Cat.No: T62448

Target: Others

Cat.No: T63590

Target: Others

Cat.No: T79451

Target: Carbonic Anhydrase

Anticancer agent 139

Cat.No: T78780

Target: Others

SW203668 (trifluoroacetate salt)

Cat.No: T35675

Target: Others

Cat.No: T84413

Synonym: Cyclin-dependent kinase 4 Inhibitor

Target: Others

3-Oxobetulin Acetate

Cat.No: T70856

Target: Others

Previridicatumtoxin

Cat.No: T37006

Target: Others

Microtubule inhibitor 4

Cat.No: T62642

Target: Others

17(R)-Resolvin D3

Cat.No: T85108

Synonym: Aspirin-triggered Resolvin D3,AT-RvD3,17(R)-RvD3,17-epi-Resolvin D3

Target: Others

Tubulin inhibitor 8

Cat.No: T13226

Target: Microtubule Associated

Cat. No.	Product Name	Target	Signaling Pathways
T25476	Gypsogenin 丝石竹皂苷元	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Gypsogenin (639-14-5) 是一种天然存在的生化物质，具有明显的抗血管生成活性和对 H460 的细胞毒性，拥有抗 ABL1 激酶和抗慢性骨髓性白血病作用。
TN4355	Jolkinol A	Others	Others
	Jolkinol A can inhibit both MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) cell lines, with GI50 values ranging between 40.9 microM and 95.3 microM.
T75524	Mutabilol	Others	Others
	Mutabilol (compound 1) 是一种有效的 p-糖蛋白 (P-gp) 调节剂。Mutabilol 是一种可以从Plectranthus mutabilis 叶中分离得到的天然产物。Mutabilol 增加 NCI-H460/R 细胞中P-gp 的表达。
TN4387	Khellactone	Antifection	Microbiology/Virology
	Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -sensitive strains of with IC(50) values from 1.5 and 2.4 microM.
T72803	Norartocarpetin	Others	Others
	Norartocarpetin 是一种酪氨酸酶抑制剂。Norartocarpetin 具有较强的酪氨酸酶抑制活性，其抑制活性 IC50值为 0.47 μM。Norartocarpetin 作为一种抗褐变剂可用于食品体系的研究。Norartocarpetin 对肺癌细胞 (NCI-H460) 也具有显著的抗癌活性，其 IC50值为 22 μM。Norartocarpetin 的抗增殖作用是通过靶向 Ras/Raf/MAPK 信号通路、线粒体介导的细胞凋亡、S 期细胞周期阻滞和抑制细胞迁移和侵袭实现的。
TN5930	Ocotillone
	Ocotillone has potent antibacterial activity against Gram-negative bacteria, P. aeruginosa and S. typhimurium, that are without hemolytic activity, whereas it has weak antimicrobial activity against Gram-positive bacteria and fungi. Ocotillone shows only
T81201	Sartorypyrone B
	Sartorypyrone B为Chevalone C的2β-乙酰氧基衍生物，由海绵源真菌Neosartorya tsunodae(KUFC 9213)的培养物中乙酸乙酯提取得到。该化合物对MCF-7、NCI-H460和A375-C5细胞系展示出较强的生长抑制活性，GI50s值分别为17.8、20.5和25.0 μM，显示其在乳腺癌、非小细胞肺癌和黑色素瘤研究中的应用潜力。
T35754	Aszonapyrone A	Others	Others
	Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, and 10.2 μM, respectively).1 Aszonapyrone A is active against multidrug-resistant isolates of S. aureus, E. faecalis, and E. faecium (MICs = 8, 16, and 16 μg/ml, respectively) and inhibits S. aureus biofilm formation.2 It is also active against P. falciparum in vitro (IC50 = 1.34...
T36489	Malformin A	Others	Others
	Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 μg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferati...

天然产物

Cat.No: T25476

Synonym: 丝石竹皂苷元

Target: Bcr-Abl

Cat.No: TN4355

Target: Others

Cat.No: T75524

Target: Others

Cat.No: TN4387

Target: Antifection

Norartocarpetin

Cat.No: T72803

Target: Others

Cat.No: TN5930

Sartorypyrone B

Cat.No: T81201

Cat.No: T35754

Target: Others

Cat.No: T36489

Target: Others

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