|
TMPH-02835
|
PDGFD Protein, Mouse, Recombinant (His & SUMO)
Platelet-derived growth factor D,Pdgfd,Spinal cord-...
|
Mouse
|
E. coli
|
|
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including inf... |
|
TMPK-00735
|
CXCL13/BCA-1 Protein, Mouse, Recombinant (His)
ANGIE,BLR1L,ANGIE2,BLC,SCYB13,BCA1,BCA-1
|
Mouse
|
HEK293 Cells
|
|
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The pred... |
|
TMPJ-00261
|
TGF beta 2 Protein, Mouse/Rat, Recombinant
transforming growth factor β-2,BSC-1 cell growth inhibitor,G...
|
Mouse,Rat
|
HEK293 Cells
|
|
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n... |
|
TMPK-00017
|
CXCL13/BCA-1 Protein, Human, Recombinant (hFc)
BCA1,BLR1L,BLC,SCYB13,ANGIE2,BCA-1,ANGIE
|
Human
|
HEK293 Cells
|
|
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The pred... |
|
TMPK-00734
|
CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc)
ANGIE,ANGIE2,BCA-1,BLR1L,BLC,BCA1,SCYB13
|
Mouse
|
HEK293 Cells
|
|
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The pred... |
|
TMPK-00018
|
CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo)
BLC,SCYB13,ANGIE,ANGIE2,BCA-1,BLR1L,BCA1
|
Human
|
E. coli
|
|
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo) is expressed in E. coli expression system with N-His-Sum... |
|
TMPY-02840
|
Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST)
UBE1,ubiquitin-like modifier activating enzyme 1,UBA1A,SMAX2...
|
Human
|
Baculovirus Insect Cells
|
|
UBE1, also known as UBA1, belongs to the ubiquitin-activating E1 family. UBE1 gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. UBE1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It also catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation by first adenylating its C-terminal glycine residue w... |
|
TMPJ-01408
|
HDGFRP3 Protein, Human, Recombinant (His)
HDGF2,HRP-3,HDGF-2,Hepatoma-Derived Growth Factor-Related Pr...
|
Human
|
HEK293 Cells
|
|
Hepatoma-Derived Growth Factor-Related Protein 3 (HDGFRP3) belongs to the HDGF family. HDGFRP3 can be found in testis, heart, spinal cord and brain. HDGFRP3 localizes to the nucleus and contains one PWWP domain. HDGFRP3 enhances DNA synthesis and may have a role in cell proliferation. |
|
TMPY-00320
|
APOA1BP Protein, Human, Recombinant (His)
YJEFN1,apolipoprotein A-I binding protein,AIBP
|
Human
|
HEK293 Cells
|
|
APOA1BP, now renamed NAXE, encodes an epimerase essential in the cellular metabolite repair for NADHX and NADPHX. The enzyme catalyzes the epimerization of NAD(P)HX, thereby avoiding the accumulation of toxic metabolites.Pathogenic biallelic mutations in NAXE in children from four families with (sub-) acute-onset ataxia, cerebellar edema, spinal myelopathy, and skin lesions. |
|
TMPK-00360
|
DLL4 Protein, Human, Recombinant (His & Avi)
notch ligand DLL4,MGC126344,δ-like 4,Delta4,δ4,Delta-like 4,...
|
Human
|
HEK293 Cells
|
|
Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibit... |
|
TMPH-02677
|
GPI Protein, Mouse, Recombinant (B2M & His)
Gpi,Phosphohexose isomerase,Phosphoglucose isomerase,Neurole...
|
Mouse
|
E. coli
|
|
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. |
|
TMPH-02678
|
GPI Protein, Mouse, Recombinant (His)
Phosphoglucose isomerase,Autocrine motility factor,Glucose-6...
|
Mouse
|
P. pastoris (Yeast)
|
|
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. GPI Protein, Mous... |
|
TMPY-03451
|
SPF30 Protein, Human, Recombinant (His)
SPF30,SMNR,TDRD16C,survival motor neuron domain containing 1
|
Human
|
E. coli
|
|
SMNDC1 gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. SMNDC1 is a nuclear protein that has been identified as a constituent of the spliceosome complex. SMNDC1 gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. SMNDC1 is necessary for spliceosome assembly. Its overexpression causes apoptosis. |
|
TMPH-02013
|
PTPRZ1 Protein, Human, Recombinant (His)
Protein-tyrosine phosphatase receptor type Z polypeptide 2,R...
|
Human
|
P. pastoris (Yeast)
|
|
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades. PTPRZ1 Protein, Human, Recombinant (His) is exp... |
|
TMPY-01620
|
MDGA2 Protein, Mouse, Recombinant (His)
6720489L24Rik,Adp,MAM domain containing glycosylphosphatidyl...
|
Mouse
|
HEK293 Cells
|
|
MAM domain-containing glycosylphosphatidylinositol anchor protein 2, also known as MAM domain-containing protein 1, MDGA2, and MAMDC1, is a cell membrane protein that contains six Ig-like (immunoglobulin-like) domains and one MAM domain. Analyses of the full-length coding region of MDGA1 and MDGA2 indicate that they encode proteins that comprise a novel subgroup of the Ig superfamily and have a unique structural organization consisting of six immunoglobulin (Ig)-like domains followed by a single... |
|
TMPH-00423
|
Tetanus toxin Protein, Clostridium tetani, Recombinant (B2M & His)
Tentoxylysin,Tetanus toxin,tetX
|
Clostridium tetani
|
E. coli
|
|
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. Tetanus toxin Protein, Clostridium tetani, Recombinant (B2M & His) is expressed in E. coli expression... |
|
TMPK-01161
|
LAMP5 Protein, Mouse, Recombinant (hFc)
C20orf103,BADLAMP,dJ1119D9.3,LAMP-5,UNC-43,BAD-LAMP
|
Mouse
|
HEK293 Cells
|
|
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. LAMP5 Protein, Mouse, Recombinant (hFc) is expressed in H... |
|
TMPK-01234
|
LAMP5 Protein, Human, Recombinant (His)
BAD-LAMP,BADLAMP,C20orf103,UNC-43,dJ1119D9.3,LAMP-5
|
Human
|
HEK293 Cells
|
|
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. LAMP5 Protein, Human, Recombinant (His) is expressed in H... |
|
TMPJ-01398
|
ITM2B Protein, Human, Recombinant (His)
Transmembrane Protein BRI,Protein E25B,BRI2,imBRI2,Immature ...
|
Human
|
HEK293 Cells
|
|
Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1(CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2(CAA-ITM2B2). CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervou... |
|
TMPJ-00584
|
Bc1-w Protein, Human, Recombinant (His)
Apoptosis Regulator Bcl-W,KIAA0271,Bcl-2-Like Protein 2,Bcl2...
|
Human
|
E. coli
|
|
Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone... |
|
TMPJ-00701
|
Carbonic Anhydrase 11 Protein, Human, Recombinant (His)
Carbonic Anhydrase-Related Protein 2,CARP XI,CA11,CARP-2,Car...
|
Human
|
HEK293 Cells
|
|
Carbonic Anhydrase-Related Protein 11 (CA11) is a secreted protein member of the α-carbonic anhydrase family. Carbonic Anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA11 is expressed abundantly in the brain with moder... |
|
TMPJ-01185
|
SULT1C4 Protein, Human, Recombinant (His)
SULT1C4,Sulfotransferase,hCG_27301,SULT1C2
|
Human
|
E. coli
|
|
Human Sulfotransferase (SULT1C4) is an enzyme that in humans is encoded by the SULT1C4 gene, belongs to the sulfotransferase 1 family. SULT1C4 is expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord. Sulfotransferase utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. It shows activity towards p-nitrophenol and N-hy... |
|
TMPJ-00763
|
ANG Protein, Human, Recombinant
RNASE5,ANG,Angiogenin,Ribonuclease 5,血管生成素,RNase 5
|
Human
|
E. coli
|
|
Angiogenin belongs to the pancreatic ribonuclease family. Angiogenin is primarily expressed in the liver. It may act as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Angiogenin is a potent stimulator of new blood vessel formation. And Angiogenin is endocytosed and translocated to the nucleus by binding to actin on the surface of endothelial cells. Angiogenic activity is regulated by interaction with RNH1 in vivo. In addition, Angiogenin... |
|
TMPH-01391
|
GPI Protein, Human, Recombinant (His)
Sperm antigen 36,Neuroleukin,Glucose-6-phosphate isomerase,G...
|
Human
|
E. coli
|
|
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. GPI Protein, Huma... |
|
TMPY-03969
|
SUSD4 Protein, Human, Recombinant (mFc)
sushi domain containing 4,PRO222
|
Human
|
HEK293 Cells
|
|
SUSD4, also known as sushi domain-containing protein 4, is a hypothetical cell surface protein whose tissue distribution and function are completely unknown. SUSD4 is detectable in murine brains, eyes, spinal cords, and testis but not other tissues. In brains, SUSD4 is highly expressed in the white matter on oligodendrocytes/axons, and in eyes, it is exclusively expressed on the photoreceptor outer segments. In in vitro complement assays, SUSD4 augments the alternative but not the classical path... |
|
TMPY-02196
|
VAPB Protein, Human, Recombinant (His)
ALS8,VAP-B,VAMP (vesicle-associated membrane protein)-associ...
|
Human
|
E. coli
|
|
Vesicle-associated membrane protein-associated protein B / C, also known as VAMP-B/VAMP-C, VAMP-associated protein B/C, VAP-B/VAP-C and VAPB, is a single-pass type IV membrane protein that belongs to the VAMP-associated protein (VAP) family. VAPB contains one MSP domain. VAPB may play a role in vesicle trafficking. VAPB forms a heterodimer with VAPA. VAPB interacts with VAMP1 and VAMP2. Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8 ( ALS8 ) which is a familial form of amy... |
|
TMPY-03521
|
DcR3 Protein, Human, Recombinant (hFc)
DCR3,tumor necrosis factor receptor superfamily member 6b,M6...
|
Human
|
Baculovirus Insect Cells
|
|
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) also known as DcR3(Decoy Receptor 3) and M68 is the tumor necrosis factor receptor superfamily. DcR3/TNFRSF6B belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tu... |
|
TMPY-03963
|
CALCB Protein, Human, Recombinant (mFc)
CGRP-II,calcitonin-related polypeptide β,calcitonin-related ...
|
Human
|
HEK293 Cells
|
|
CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of ... |
|
TMPY-02759
|
Kallikrein 6/KLK6 Protein, Human, Recombinant (His)
kallikrein-related peptidase 6,PRSS18,PRSS9,Klk7,Bssp,SP59,h...
|
Human
|
HEK293 Cells
|
|
KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 sh... |
|
TMPY-02717
|
GPR37 Protein, Human, Recombinant (His)
hET(B)R-LP,PAELR,G protein-coupled receptor 37 (endothelin r...
|
Human
|
HEK293 Cells
|
|
GPR37 (cathepsin Z) is an orphan receptor that belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors are a large protein family comprised of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. They only exist in eukaryotes, including yeast, choanoflagellates, and animals. These receptors are bonded and activated by light-sensitive compounds, odors, pheromones, hormones, and n... |
|
TMPJ-00490
|
Serpin A5 Protein, Human, Recombinant (His)
Plasminogen Activator Inhibitor 3,Acrosomal Serine Protease ...
|
Human
|
HEK293 Cells
|
|
Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes o... |
|
TMPY-01479
|
SPG3A Protein, Human, Recombinant (GST)
HSN1D,atlastin GTPase 1,FSP1,atlastin1,GBP3,SPG3,SPG3A,AD-FS...
|
Human
|
Baculovirus Insect Cells
|
|
Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to theGBP family and atlastin subfamily. ATL1 / SPG3A is expressed predominantly in the adult and fetal central nervous system. Expression of ATL1 / SPG3A in adult brain is at least 5-fold higher than in other tissues. ATL1 / SPG3A is detected predominantly in pyramidal neurons in the cerebral cortex and... |
|
TMPY-01992
|
Kallikrein 8/KLK8 Protein, Human, Recombinant (His)
kallikrein-related peptidase 8,PRSS19,TADG14,NRPN,NP,HNP
|
Human
|
HEK293 Cells
|
|
Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, and KLK8 is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. It is a serine protease that is capable of degrading some proteins such as casein, fibrinogen, kininogen, fibronectin, and collagen type IV. Kallikrein-8 / KLK8 plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-c... |
沪公网安备 31010602006700号