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Idoxuridine

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产品编号 T0863Cas号 54-42-2
别名 碘苷, SKF 14287, NSC 39661, IDU, Dendrid, 5-IUdR, 5-Iodo-2′-deoxyuridine

Idoxuridine (Dendrid) 是一种抑制病毒 DNA 合成的脱氧尿苷类似物,用作抗病毒剂。

Idoxuridine

Idoxuridine

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纯度: 99.62%
产品编号 T0863 别名 碘苷, SKF 14287, NSC 39661, IDU, Dendrid, 5-IUdR, 5-Iodo-2′-deoxyuridineCas号 54-42-2

Idoxuridine (Dendrid) 是一种抑制病毒 DNA 合成的脱氧尿苷类似物,用作抗病毒剂。

规格价格库存数量
500 mg¥ 172现货
1 g¥ 272现货
5 g¥ 622现货
10 g¥ 913现货
1 mL x 10 mM (in DMSO)¥ 189现货
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产品介绍

生物活性
产品描述
Idoxuridine (Dendrid) is an analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.
靶点活性
FHV-1:4.3 μM
体外活性
Idoxuridine is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing.Idoxuridine is used for topical treatment of herpetic eye infections due to herpes simplex virus (HSV)[2].
细胞实验
The CRFK cells are cultured in 25-cm2 flasks that contained DMEM with 10% FBS. The concentration of idoxuridine is 5, 10, and 50 μM. Cells from 1 control flask and 1 flask containing each drug concentration are examined by use of an inverted microscope to detect morphologic changes and evaluate confluence, and cells are then harvested at 24, 48, and 72 hours. Culture medium is decanted, and the monolayer is rinsed once with PBS solution. Cells are then enzymatically detached with trypsin-EDTA solution. Trypsinization is stopped by the addition of DMEM with 10% FBS, and cells are forcefully pipetted to ensure complete detachment from the flasks. Each flask is then rinsed once with DMEM with 10% FBS, and the eluent is combined with the first cell suspension to ensure collection of as many cells as possible from each flask. Cell-containing medium is centrifuged (300 X g for 6 minutes), and the supernatant is decanted. Cells are then resuspended in a known volume of DMEM and counted on a hemacytometer. Cells cultured in each drug concentration at each time point are counted twice, and the total number of cells in each flask is calculated. (Only for Reference)
别名碘苷, SKF 14287, NSC 39661, IDU, Dendrid, 5-IUdR, 5-Iodo-2′-deoxyuridine
化学信息
分子量354.1
分子式C9H11IN2O5
CAS No.54-42-2
SmilesOCC1OC(CC1O)n1cc(I)c(=O)[nH]c1=O
密度2.14g/cm3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 45 mg/mL (127.08 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
溶液配制表
1mg5mg10mg50mg
1 mM2.8241 mL14.1203 mL28.2406 mL141.2030 mL
5 mM0.5648 mL2.8241 mL5.6481 mL28.2406 mL
10 mM0.2824 mL1.4120 mL2.8241 mL14.1203 mL
20 mM0.1412 mL0.7060 mL1.4120 mL7.0602 mL
50 mM0.0565 mL0.2824 mL0.5648 mL2.8241 mL
100 mM0.0282 mL0.1412 mL0.2824 mL1.4120 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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