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PGC-1α

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. It may have played a key role in differentiating humans from apes.PGC-1α is the master regulator of mitochondrial biogenesis. PGC-1α is also the primary regulator of liver gluconeogenesis, inducing increased gene expression for gluconeogenesis.

SR-18292
T43532095432-55-4
SR-18292 是一种 PPARγ 共激活因子-1α (PGC-1α) 抑制剂,可增加 PGC-1α 乙酰化,抑制糖异生基因表达并减少肝细胞中的葡萄糖生成。
  • ¥ 235
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TargetMol | Inhibitor Sale
TargetMol | Citations 客户已引用
ZLN005
T180249671-76-3
ZLN005 是一种有效的组织特异性 PGC-1α 转录激活剂。
  • ¥ 272
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TargetMol | Inhibitor Sale
11-Oxoisomogroside V
T799652149606-15-3
11-Oxoisomogroside V(compound 3)是从罗汉果粗提物中分离的一种葫芦苷,能够激活PGC-1α的转录活性。荧光素酶实验表明,10 μM 和 20 μM 浓度的11-Oxoisomogroside V分别将荧光素酶活性提高至 133.79% 和 143.81%。
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